45 results on '"Börst, H."'
Search Results
2. The technical performance of the HEGRA system of imaging air Cherenkov telescopes
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Pühlhofer, G, Bolz, O, Götting, N, Heusler, A, Horns, D, Kohnle, A, Lampeitl, H, Panter, M, Tluczykont, M, Aharonian, F, Akhperjanian, A, Beilicke, M, Bernlöhr, K, Börst, H, Bojahr, H, Coarasa, T, Contreras, J.L, Cortina, J, Denninghoff, S, Fonseca, M.V, Girma, M, Heinzelmann, G, Hermann, G, Hofmann, W, Jung, I, Kankanyan, R, Kestel, M, Konopelko, A, Kornmeyer, H, Kranich, D, Lopez, M, Lorenz, E, Lucarelli, F, Mang, O, Meyer, H, Mirzoyan, R, Moralejo, A, Ona-Wilhelmi, E, Plyasheshnikov, A, de los Reyes, R, Rhode, W, Ripken, J, Rowell, G, Sahakian, V, Samorski, M, Schilling, M, Siems, M, Sobzynska, D, Stamm, W, Vitale, V, Völk, H.J, Wiedner, C.A, and Wittek, W
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- 2003
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3. Limits on the TeV flux of diffuse gamma rays as measured with the HEGRA air shower array
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Aharonian, F.A., Akhperjanian, A.G., Barrio, J.A., Bernlöhr, K., Bojahr, H., Bolz, O., Börst, H., Contreras, J.L., Cortina, J., Denninghoff, S., Fonseca, V., Gebauer, H.J., Gonzalez, J.C., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Ibarra, A., Iserlohe, C., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmayer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Magnussen, N., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Oña, E., Padilla, L., Panter, M., Plaga, R., Plyasheshnikov, A., Prahl, J., Pühlhofer, G., Rauterberg, G., Rhode, W., Röhring, A., Rowell, G.P., Sahakian, V., Samorski, M., Schilling, M., Schröder, F., Siems, M., Stamm, W., Tluczykont, M., Völk, H.J., Wiedner, C., and Wittek, W.
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- 2002
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4. Variations of the TeV energy spectrum at different flux levels of Mkn 421 observed with the HEGRA system of Cherenkov telescopes
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J., Cortina, J., Costamante, L., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Fabrizio Lucarelli, Mang, O., Meyer, H., Mirzoyan, R., Milite, M., Moralejo, A., Ona, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Rauterberg, G., Reyes, R., Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., Wittek, W., and Remillard, R. A.
- Subjects
Physics ,Photon ,Astrophysics::High Energy Astrophysical Phenomena ,Astrophysics (astro-ph) ,Mid infrared ,FOS: Physical sciences ,HEGRA ,Astronomy and Astrophysics ,Astrophysics ,Power law ,Spectral line ,Space and Planetary Science ,Energy spectrum ,Cherenkov radiation ,Background radiation - Abstract
The nearby BL Lacertae (BL Lac) object Markarian~421 (Mkn~421) at a red shift z=0.031 was observed to undergo strong TeV Gamma-ray outbursts in the observational periods from December 1999 until May 2001. The time averaged energy spectrum is well described by a power law with an exponential cut-off energy at 3.6(+0.4-0.3)_{stat}(+0.9-0.8)_{sys} TeV. The energy spectra derived for different average flux levels ranging from 0.5 to 10 * 10^{-11}ph/cm**2/s follow a clear correlation of photon index and flux level. Generally, the energy spectra are harder for high flux levels. From January to April 2001 Mkn~421 showed rapid variability (doubling time as short as 20 minutes), accompanied with a spectral hardening with increasing flux level within individual nights. For two successive nights (MJD 51989-51991, March 21-23,2001), this correlation of spectral hardness and change in flux has been observed within a few hours. The cut-off energy for the Mkn~421 TeV spectrum remains within the errors constant for the different flux levels and differs by 2.6+/-0.6_stat+/-0.6_sys TeV from the value determined for Mkn~501. This indicates that the observed exponential cut-off in the energy spectrum of Mkn~421 is not solely caused by absorption of multi-TeV photons by pair-production processes with photons of the extragalactic near/mid infrared background radiation., Comment: 12 pages, 9 figures, submitted to Astronomy&Astrophysics
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- 2002
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5. The 2(nd) Berlin BedRest Study: protocol and implementation
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Belavy DL 1, Bock O 1, Börst H 1, Armbrecht G 1, Gast U 1, Degner C 1, Beller G 1, Soll H 2, Salanova M 3, Habazettl H. 4, Heer M 5, de Haan A 6, Stegeman DF 6, 7, Cerretelli P 8, Blottner D 3, Rittweger J 9, Gelfi C 10, Kornak U 11, and Felsenberg D 1
- Subjects
Countermeasures ,Spaceflight ,Microgravity ,Inactivity ,Exercise - Abstract
Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p=.17). Body weight changes differed between groups (p
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- 2010
6. Observations of H1426+428 with HEGRA -- Observations in 2002 and reanalysis of 1999&2000 data
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H. -G, Bojahr, H., Bolz, O., Coarasa, T., Contreras, J. L., Juan Cortina, Costamante, L., Denninghoff, S., Fonseca, M. V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Mazine, D., Meyer, H., Mirzoyan, R., Moralejo, A., Ona-Wilhelmi, E., Panter, M., Plyasheshnikov, A., Prahl, J., Pühlhofer, G., Los Reyes, R., Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Vitale, V., Völk, H. J., Wiedner, C. A., and Wittek, W.
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Physics ,Astrophysics::High Energy Astrophysical Phenomena ,Flux ,HEGRA ,Astronomy and Astrophysics ,Astrophysics ,Spectral line ,Wavelength ,Extragalactic background light ,Space and Planetary Science ,Absorption (electromagnetic radiation) ,Cherenkov radiation ,BL Lac object - Abstract
The HEGRA system of imaging air Cherenkov telescopes has been used to observe the BL Lac object H1426+428 ($z=0.129$) for 217.5 hours in 2002. In this data set alone, the source is detected at a confidence level of $5.3~\sigma$, confirming this object as a TeV source. The overall flux level during the observations in 2002 is found to be a factor of $\approx 2.5$ lower than during the previous observations by HEGRA in 1999&2000. A new spectral analysis has been carried out, improving the signal-to-noise ratio at the expense of a slightly increased systematic uncertainty and reducing the relative energy resolution to $\Delta E/E\le 12 %$ over a wide range of energies. The new method has also been applied to the previously published data set taken in 1999 and 2000, confirming the earlier claim of a flattening of the energy spectrum between 1 and 5 TeV. The data set taken in 2002 shows again a signal at energies above 1 TeV. We combine the energy spectra as determined by the CAT and VERITAS groups with our reanalyzed result of the 1999&2000 data set and apply a correction to account for effects of absorption of high energy photons on extragalactic background light in the optical to mid infrared band. The shape of the inferred source spectrum is mostly sensitive to the characteristics of the extragalactic background light between wavelengths of 1 and 15~$\mu$m, Comment: 12 pages, 4 Figures, submitted to A&A
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- 2003
7. The 2nd Berlin BedRest Study: protocol and implementation
- Author
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Belavý, D.L., Bock, O., Börst, H., Armbrecht, G., Gast, U., Degner, C., Beller, G., Soll, H., Salanova, M., Habazettl, H., Heer, M., de Haan, A., Stegeman, D.F., Cerretelli, P., Blottner, D., Rittweger, J., Gelfi, C., Kornak, U., Felsenberg, D., Belavý, D.L., Bock, O., Börst, H., Armbrecht, G., Gast, U., Degner, C., Beller, G., Soll, H., Salanova, M., Habazettl, H., Heer, M., de Haan, A., Stegeman, D.F., Cerretelli, P., Blottner, D., Rittweger, J., Gelfi, C., Kornak, U., and Felsenberg, D.
- Abstract
Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p < .0001), though similarly in all groups (p > or = .17). Body weight changes differed between groups (p < .0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVE-group displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest methodology are also discussed.
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- 2010
8. Sportliche Aktivitäten, Vitamin D Konzentration und Knochendichte bei Frauen mit primärer und sekundärer Osteoporose, eine prospektive Studie - erste Baseline Ergebnisse
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Stege, U, primary, Börst, H, additional, Tews, K, additional, Tung, ML, additional, and Felsenberg, D, additional
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- 2012
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9. Stürze, sportliche Aktivitäten und Vitamin D 3 Konzentration von Frauen mit primärer und sekundärer Osteoporose, eine prospektive Studie - erste Baseline Ergebnisse
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Stege, U, primary, Börst, H, additional, Tews, K, additional, Tung, ML, additional, and Felsenberg, D, additional
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- 2012
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10. Ergebnisse der nichtinterventionellen PERSPECTIVES-Studie
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Stege, U., primary, Degner, C., primary, Börst, H., primary, Bock, O., primary, and Felsenberg, D., additional
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- 2012
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11. Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed rest
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Belavý, D. L., primary, Beller, G., additional, Armbrecht, G., additional, Perschel, F. H., additional, Fitzner, R., additional, Bock, O., additional, Börst, H., additional, Degner, C., additional, Gast, U., additional, and Felsenberg, D., additional
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- 2010
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12. Monthly oral ibandronate 150 mg improves significantly bone density and structure measured in Vivo by Micro-CT at distal tibia in postmenopausal women with mild osteoporosis
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Börst, H., primary, Bock, O., additional, Beller, G., additional, Kratzsch, M., additional, Degner, C., additional, Profittlich, H., additional, Kalbow, M., additional, Armbrecht, G., additional, Martus, P., additional, Glaab, J., additional, and Felsenberg, D., additional
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- 2010
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13. Compliance, persistence and patient satisfaction in 150 mg once-monthly oral ibandronate treated patients with postmenopausal osteoporosis — A non-interventional study
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Börst, H., primary, Felsenberg, D., additional, Glaab, J., additional, and Bock, O., additional
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- 2009
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14. Observations of 14 young open star clusters with the HEGRA system of Cherenkov telescopes
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Aharonian, F., primary, Akhperjanian, A., additional, Beilicke, M., additional, Bernlöhr, K., additional, Börst, H.-G., additional, Bojahr, H., additional, Bolz, O., additional, Coarasa, T., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, M. V., additional, Girma, M., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Lampeitl, H., additional, Lopez, M., additional, Lorenz, E., additional, Lucarelli, F., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Ona-Wilhelmi, E., additional, Panter, M., additional, Plyasheshnikov, A., additional, Pühlhofer, G., additional, de los Reyes, R., additional, Rhode, W., additional, Ripken, J., additional, Rowell, G., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Siems, M., additional, Sobzynska, D., additional, Stamm, W., additional, Tluczykont, M., additional, Vitale, V., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
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- 2006
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15. Search for TeV gamma ray emission from the Andromeda galaxy
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Aharonian, F. A., primary, Akhperjanian, A. G., additional, Beilicke, M., additional, Bernlöhr, K., additional, Bojahr, H., additional, Bolz, O., additional, Börst, H., additional, Coarasa, T., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Girma, M., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lopez, M., additional, Lorenz, E., additional, Lucarelli, F., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Ona, E., additional, Panter, M., additional, Plyasheshnikov, A., additional, Pühlhofer, G., additional, Rauterberg, G., additional, Reyes, R., additional, Rhode, W., additional, Ripken, J., additional, Röhring, A., additional, Rowell, G. P., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Siems, M., additional, Sobzynska, D., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
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- 2003
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16. A search for TeV gamma-ray emission from SNRs, pulsars and unidentified GeV sources in the Galactic plane in the longitude range between $-2^\circ$ and $85^\circ$
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Aharonian, F. A., primary, Akhperjanian, A. G., additional, Beilicke, M., additional, Bernlöhr, K., additional, Bojahr, H., additional, Bolz, O., additional, Börst, H., additional, Coarasa, T., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Girma, M., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lopez, M., additional, Lorenz, E., additional, Lucarelli, F., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Ona, E., additional, Panter, M., additional, Plyasheshnikov, A., additional, Pühlhofer, G., additional, Rauterberg, G., additional, Reyes, R., additional, Rhode, W., additional, Ripken, J., additional, Röhring, A., additional, Rowell, G. P., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Siems, M., additional, Sobzynska, D., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
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- 2002
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17. Search for point sources of gamma radiation above 15 TeV with the HEGRA AIROBICC array
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Aharonian, F., primary, Akhperjanian, A., additional, Barrio, J. A., additional, Bernlöhr, K., additional, Börst, H., additional, Bojahr, H., additional, Bolz, O., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Gebauer, H. J., additional, González, J., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmayer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, López, M., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Oña, E., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Prahl, J., additional, Pühlhofer, G., additional, Rauterberg, G., additional, Röhring, A., additional, Rhode, W., additional, Rowell, G., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schmele, D., additional, Schröder, F., additional, Sevilla, I., additional, Siems, M., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
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- 2002
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18. TeV gamma rays from the blazar H 1426+428 and the diffuse extragalactic background radiation
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Aharonian, F., primary, Akhperjanian, A., additional, Barrio, J., additional, Beilicke, M., additional, Bernlöhr, K., additional, Börst, H., additional, Bojahr, H., additional, Bolz, O., additional, Contreras, J., additional, Cornils, R., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Girma, M., additional, Gonzalez, J., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lopez, M., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Ona, E., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Pühlhofer, G., additional, Rauterberg, G., additional, Röhring, A., additional, Rhode, W., additional, Robrade, J., additional, Rowell, G., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schröder, F., additional, Sevilla, I., additional, Siems, M., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
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- 2002
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19. TeV gamma-ray observations of SS-433 and a survey of the surrounding field with the HEGRA IACT-System
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H.-G., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kohnle, A., Konopelko, A., Kranich, D., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Mazin, D., Meyer, H., Mirzoyan, R., Moralejo, A., Oña-Wilhelmi, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Vitale, V., Völk, H. J., Wiedner, C. A., Wittek, W., Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H.-G., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kohnle, A., Konopelko, A., Kranich, D., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Mazin, D., Meyer, H., Mirzoyan, R., Moralejo, A., Oña-Wilhelmi, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Vitale, V., Völk, H. J., Wiedner, C. A., and Wittek, W.
- Abstract
We present results of a search for TeV γ-ray emission from the microquasar SS-433 and the surrounding region covering a ~$8^\circ$$\times$$8^\circ$field of view. Analysis of data taken with the HEGRA stereoscopic system of imaging atmospheric Čerenkov imaging telescopes reveals no evidence of steady or variable emission from any position. Observation times of over 100 h have been achieved in central parts of the field of view. We set 99% confidence level upper limits to a number of a-priori-chosen objects of interest, including SS-443 and its interaction regions, 32 pulsars, 3 supernova remnants and the GeV source GeV J1907+0537. Our upper limit of 3.2% Crab flux (for energies $E>0.8$TeV) for the eastern-lobe region e3of SS-433 permits, after comparison with X-ray fluxes, a lower limit of $B\geq19~\mu$G on the post-shocked magnetic field in this region. An ensemble upper limit at 0.3% Crab flux ($E>0.7$TeV) from a subset (11) of the 32 pulsars implies a maximum of 4.5% of the spin-down pulsar power is available for TeV γ-ray production. For one of the SNR in our FoV, 3C 396, recent Chandra observations suggest that a central pulsar-driven wind nebula may be the source of X-ray emission. Our upper limit implies that a maximum of 0.1% of the spin-down power from the central source of 3C 396 would be available for TeV γ-rays.
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- 2005
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20. A search for gamma-ray emission from the Galactic plane in the longitude range between $\mathsf{37}^\circ$ and $\mathsf{43}^\circ$
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Aharonian, F. A., primary, Akhperjanian, A. G., additional, Barrio, J. A., additional, Bernlöhr, K., additional, Bolz, O., additional, Börst, H., additional, Bojahr, H., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Gonzalez, J. C., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Ibarra, A., additional, Iserlohe, C., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Prahl, J., additional, Pühlhofer, G., additional, Rhode, W., additional, Röhring, A., additional, Rowell, G. P., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schröder, F., additional, Siems, M., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
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- 2001
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21. A study of Tycho's SNR at TeV energies with the HEGRA CT-System
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Aharonian, F. A., primary, Akhperjanian, A. G., additional, Barrio, J. A., additional, Bernlöhr, K., additional, Börst, H., additional, Bojahr, H., additional, Bolz, O., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Gonzalez, J. C., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Ibarra, A., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Prahl, J., additional, Pühlhofer, G., additional, Rauterberg, G., additional, Röhring, A., additional, Rhode, W., additional, Rowell, G. P., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schröder, F., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C., additional, and Wittek, W., additional
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- 2001
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22. Evidence for TeV gamma ray emission from Cassiopeia A
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Aharonian, F., primary, Akhperjanian, A., additional, Barrio, J., additional, Bernlöhr, K., additional, Börst, H., additional, Bojahr, H., additional, Bolz, O., additional, Contreras, J., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Gonzalez, J., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Ibarra, A., additional, Iserlohe, C., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lopez, M., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Ona, E., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Prahl, J., additional, Pühlhofer, G., additional, Rauterberg, G., additional, Röhring, A., additional, Rhode, W., additional, Rowell, G. P., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schröder, F., additional, Siems, M., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
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- 2001
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23. Search for a TeV gamma-ray halo of Mkn 501
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Aharonian, F. A., primary, Akhperjanian, A. G., additional, Barrio, J. A., additional, Bernlöhr, K., additional, Bolz, O., additional, Börst, H., additional, Bojahr, H., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Gonzalez, J. C., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Ibarra, A., additional, Iserlohe, C., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Prahl, J., additional, Pühlhofer, G., additional, Rhode, W., additional, Röhring, A., additional, Rowell, G. P., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schröder, F., additional, Siems, M., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C., additional, and Wittek, W., additional
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- 2001
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24. Reanalysis of the high energy cutoff of the 1997 Mkn 501 TeV energy spectrum
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Aharonian, F. A., primary, Akhperjanian, A. G., additional, Barrio, J. A., additional, Bernlöhr, K., additional, Bolz, O., additional, Börst, H., additional, Bojahr, H., additional, Contreras, J. L., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Gonzalez, J. C., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Ibarra, A., additional, Iserlohe, C., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Prahl, J., additional, Pühlhofer, G., additional, Rhode, W., additional, Röhring, A., additional, Rowell, G. P., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schröder, F., additional, Siems, M., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C., additional, and Wittek, W., additional
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- 2001
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25. Observation of the Monoceros Loop SNRregion with the HEGRA system of IACTs
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Aharonian, F. A., Akhperjanian, A. G., Beilicke, M., Bernlöhr, K., Börst, H.-G., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, M. V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Ona-Wilhelmi, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Vitale, V., Völk, H. J., Wiedner, C. A., Wittek, W., Aharonian, F. A., Akhperjanian, A. G., Beilicke, M., Bernlöhr, K., Börst, H.-G., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, M. V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Ona-Wilhelmi, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Vitale, V., Völk, H. J., Wiedner, C. A., and Wittek, W.
- Abstract
The array of 5 imaging atmospheric Čerenkov telescopes (IACTs) deployed at La Palma (Canary Islands), and operated by the HEGRA (High Energy Gamma Ray Astronomy) collaboration, was used for observations of the Monoceros Loop SNRregion for a total of about 120 hrs and 20 hrs in ON-source and OFF-source mode, respectively. The giant molecular cloud Rosette Nebula appears in the sky region, close to the south-east part of the SNRrim. Using the HEGRA system of IACTs of rather large field of view (4.3 degree in diameter), we have mapped the extended sky region of $3^\circ \times 3^\circ$associated with the Monoceros SNR/Rosette Nebula, which is centered towards the hard spectrum X-ray point source SAX J0635+533. The EGRET unidentified source of diffuse γ-ray emission (3EG J0634+0521) observed in the energy range between 100 MeV–10 GeV, was effectively in the field of view of our present observations. Also, the GeV source GeV J0633+0645 was within the available field of view. The performance of the IACTs array reveals an energy threshold of 500 GeV and an angular resolution of $0.1^\circ$for γ-rays. In what follows, we present the result of the data analysis and its physical interpretation.
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- 2004
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26. TeV γ-ray light curve and energy spectrum of Mkn 421during its 2001 flare as measured with HEGRA CT1*
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H. G., Bojahr, H., Bolz, O., Coarasa, J. A., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Goebel, F., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kranich, D., Krawczynski, H., Lampeitl, H., López, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Oña-Wilhelmi, E., Paneque, D., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Schweizer, T., Sevilla, I., Siems, M., Sobczyńska, D., Stamm, W., Tluczykont, M., Tonello, N., Vitale, V., Völk, H. J., Wagner, R. M., Wiedner, C. A., Wittek, W., Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H. G., Bojahr, H., Bolz, O., Coarasa, J. A., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Goebel, F., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kranich, D., Krawczynski, H., Lampeitl, H., López, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Oña-Wilhelmi, E., Paneque, D., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Schweizer, T., Sevilla, I., Siems, M., Sobczyńska, D., Stamm, W., Tluczykont, M., Tonello, N., Vitale, V., Völk, H. J., Wagner, R. M., Wiedner, C. A., and Wittek, W.
- Abstract
In the first months of 2001 the AGN Mkn 421showed highly variable, strong TeV activity at flux levels frequently exceeding 1 Crab. Here we present the light curve and energy spectrum of Mkn 421as measured with the HEGRA stand alone telescope CT1. Around 30% of the data were taken under moonlight conditions. The spectrum shows a significant exponential energy cutoff at around 3.4 TeV. The results from the dark night- and the moon data are in excellent agreement with each other. A significant spectral shape variation depending on the flux level has been found. The TeV light curve is also found to be highly correlated with the X-ray light curve of the RXTE / ASM satellite, showing no significant time lag larger than 0.2 d. The derived correlation coefficient of 0.83 corresponds to a $5.2~\sigma$significance.
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- 2003
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27. Detection of TeV gamma-rays from the BL Lac 1ES 1959+650 in its low states and during a major outburst in 2002 *
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H.-G., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, M. V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Ona-Wilhelmi, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Robrade, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Vitale, V., Völk, H. J., Wiedner, C. A., Wittek, W., Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H.-G., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, M. V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Ona-Wilhelmi, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Reyes, R. de los, Rhode, W., Ripken, J., Robrade, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Vitale, V., Völk, H. J., Wiedner, C. A., and Wittek, W.
- Abstract
TeV γ-rays from the BL Lac object 1ES 1959+650 have been measured during the years 2000 and 2001 with a significance of 5.2 σat a value of 5.3% of the Crab flux and in May 2002 during strong outbursts with >$23\,\sigma$at a flux level of up to 2.2 Crab, making 1ES 1959+650 the TeV Blazar with the third best event statistics. The deep observation of 197.4 h has been performed with the HEGRA stereoscopic system of 5 imaging atmospheric Cherenkov telescopes (IACT system). 1ES 1959+650 is located at a redshift of $z = 0.047$, providing an intermediate distance between the nearby Blazars Mkn 421 and Mkn 501, and the much more distant object H1426+428. This makes 1ES 1959+650 an important member of the class of TeV Blazars in view of the absorption of TeV photons by the diffuse extragalactic background radiation (DEBRA). The differential energy spectrum of 1ES 1959+650 during the flares can be fitted by a power law with a spectral index of $2.83 \pm 0.14_{\mbox{\tiny stat}} \pm 0.08_{\mbox{\tiny sys}}$or by a power law with an exponential cut-off at $(4.2^{+0.8}_{-0.6~{\mbox{\tiny stat}}} \pm 0.9_{\mbox{\tiny sys}})$TeV and a spectral index of $1.83 \pm 0.15_{\mbox{\tiny stat}} \pm 0.08_{\mbox{\tiny sys}}$. The low state differential energy spectrum obtained with lower statistics can be described by a pure power law with a spectral index of $3.18 \pm 0.17_{\mbox{\tiny stat}} \pm 0.08_{\mbox{\tiny sys}}$.
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- 2003
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28. A search for TeV gamma-ray emission from SNRs, pulsars and unidentified GeV sources in the Galactic plane in the longitude range between $-2^\circ$and $85^\circ$
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Aharonian, F. A., Akhperjanian, A. G., Beilicke, M., Bernlöhr, K., Bojahr, H., Bolz, O., Börst, H., Coarasa, T., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Ona, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Rauterberg, G., Reyes, R., Rhode, W., Ripken, J., Röhring, A., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., Wittek, W., Aharonian, F. A., Akhperjanian, A. G., Beilicke, M., Bernlöhr, K., Bojahr, H., Bolz, O., Börst, H., Coarasa, T., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Ona, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Rauterberg, G., Reyes, R., Rhode, W., Ripken, J., Röhring, A., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., and Wittek, W.
- Abstract
Using the HEGRA system of imaging atmospheric Cherenkov telescopes, one quarter of the Galactic plane ($-2^\circ < l < 85^\circ$) was surveyed for TeV gamma-ray emission from point sources and moderately extended sources (Ø$\;\le0.8^\circ$). The region covered includes 86 known pulsars (PSR), 63 known supernova remnants (SNR) and nine GeV sources, representing a significant fraction of the known populations. No evidence for emission of TeV gamma radiation was detected, and upper limits range from 0.15 Crab units up to several Crab units, depending on the observation time and zenith angles covered. The ensemble sums over selected SNR and pulsar subsamples and over the GeV-sources yield no indication of emission from these potential sources. The upper limit for the SNR population is 6.7% of the Crab flux and for the pulsar ensemble is 3.6% of the Crab flux.
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- 2002
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29. Variations of the TeV energy spectrum at different flux levels of Mkn 421observed with the HEGRA system of Cherenkov telescopes
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J., Cortina, J., Costamante, L., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Milite, M., Moralejo, A., Ona, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Rauterberg, G., Reyes, R., Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., Wittek, W., Remillard, R. A., Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J., Cortina, J., Costamante, L., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Mang, O., Meyer, H., Mirzoyan, R., Milite, M., Moralejo, A., Ona, E., Panter, M., Plyasheshnikov, A., Pühlhofer, G., Rauterberg, G., Reyes, R., Rhode, W., Ripken, J., Rowell, G., Sahakian, V., Samorski, M., Schilling, M., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., Wittek, W., and Remillard, R. A.
- Abstract
The nearby BL Lacertae (BL Lac) object Markarian 421 (Mkn 421) at a red shift $z=0.031$was observed to undergo strong TeV γ-ray outbursts in the observational periods from December 1999 until May 2001. The time averaged flux level $F(E>1{\rm \,TeV})$in the 1999/2000 season was $(1.43\pm0.04)$$\times$10-11ph cm-2s-1, whereas in the 2000/2001 season the average integral flux increased to $(4.19\pm0.04)$$\times$10-11ph cm-2s-1. Both energy spectra are curved and well fit by a power law with an exponential cut-off energy at $3.6(+0.4-0.3)_{\rm stat}(+0.9-0.8)_{\rm sys}$TeV. The respective energy spectra averaged over each of the two time periods indicate a spectral hardening for the 2000/2001 spectrum. The photon index changes from $2.39\pm0.09_{\rm stat}$for 1999/2000 to $2.19\pm0.02_{\rm stat}$in 2000/2001. The energy spectra derived for different average flux levels ranging from 0.5 to 10 $\times$10-11ph cm-2s-1follow a clear correlation of photon index and flux level. Generally, the energy spectra are harder for high flux levels. From January to April 2001 Mkn 421showed rapid variability (doubling time as short as 20 min), accompanied with a spectral hardening with increasing flux level within individual nights. For two successive nights (MJD 51989-51991, March 21-23, 2001), this correlation of spectral hardness and change in flux has been observed within a few hours. The cut-off energy for the Mkn 421TeV spectrum remains within the errors constant for the different flux levels and differs by $\Delta E=2.6\pm0.6_{\rm stat}\pm0.6_{\rm sys}$TeV from the value determined for Mkn 501. This indicates that the observed exponential cut-off in the energy spectrum of Mkn 421is not solely caused by absorption of multi-TeV photons by pair-production processes with photons of the extragalactic near/mid infrared background radiation.
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- 2002
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30. An unidentified TeV source in the vicinity of Cygnus OB2
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Magnussen, N., Mang, O., Meyer, H., Milite, M., Mirzoyan, R., Moralejo, A., Ona, E., Panter, M., Plyasheshnikov, A., Prahl, J., Pühlhofer, G., Rauterberg, G., Reyes, R., Rhode, W., Ripken, J., Röhring, A., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Schröder, F., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., Uchiyama, Y., Takahashi, T., Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H., Bojahr, H., Bolz, O., Coarasa, T., Contreras, J., Cortina, J., Denninghoff, S., Fonseca, V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lopez, M., Lorenz, E., Lucarelli, F., Magnussen, N., Mang, O., Meyer, H., Milite, M., Mirzoyan, R., Moralejo, A., Ona, E., Panter, M., Plyasheshnikov, A., Prahl, J., Pühlhofer, G., Rauterberg, G., Reyes, R., Rhode, W., Ripken, J., Röhring, A., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Schröder, F., Siems, M., Sobzynska, D., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., Uchiyama, Y., and Takahashi, T.
- Abstract
Deep observation (~113 hrs) of the Cygnus region at TeV energies using the HEGRA stereoscopic system of air Čerenkov telescopes has serendipitously revealed a signal positionally inside the core of the OB association Cygnus OB2, at the edge of the 95% error circle of the EGRET source 3EG J2033+4118, and ~$0.5^\circ$north of Cyg X-3. The source centre of gravity is RA $\alpha_{\rm J2000}$: $20^{\rm hr} 32^{\rm m} 07^{\rm s}\pm 9.2^{\rm s}_{\rm stat} \pm2.2^{\rm s}_{\rm sys}$, Dec $\delta_{\rm J2000}$: $+41^\circ 30^\prime 30^{\prime\prime}\pm 2.0^\prime_{\rm stat} \pm 0.4^\prime_{\rm sys}$. The source is steady, has a post-trial significance of +4.6σ, indication for extension with radius $5.6^\prime$at the ~$3\sigma$level, and has a differential power-law flux with hard photon index of $-1.9 \pm0.3_{\rm stat}\pm0.3_{\rm sys}$. The integral flux above 1 TeV amounts ~3% that of the Crab. No counterpart for the TeV source at other wavelengths is presently identified, and its extension would disfavour an exclusive pulsar or AGN origin. If associated with Cygnus OB2, this dense concentration of young, massive stars provides an environment conducive to particle acceleration and likely subsequent interaction with a nearby gas cloud. Alternatively, one could envisage γ-ray production via a jet-driven termination shock.
- Published
- 2002
- Full Text
- View/download PDF
31. A search for gamma-ray emission from the Galactic plane in the longitude range between $\mathsf{37}^\circ$and $\mathsf{43}^\circ$
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Aharonian, F. A., Akhperjanian, A. G., Barrio, J. A., Bernlöhr, K., Bolz, O., Börst, H., Bojahr, H., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, V., Gonzalez, J. C., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Ibarra, A., Iserlohe, C., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lorenz, E., Lucarelli, F., Magnussen, N., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Padilla, L., Panter, M., Plaga, R., Plyasheshnikov, A., Prahl, J., Pühlhofer, G., Rhode, W., Röhring, A., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Schröder, F., Siems, M., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., Wittek, W., Aharonian, F. A., Akhperjanian, A. G., Barrio, J. A., Bernlöhr, K., Bolz, O., Börst, H., Bojahr, H., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, V., Gonzalez, J. C., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Ibarra, A., Iserlohe, C., Jung, I., Kankanyan, R., Kestel, M., Kettler, J., Kohnle, A., Konopelko, A., Kornmeyer, H., Kranich, D., Krawczynski, H., Lampeitl, H., Lorenz, E., Lucarelli, F., Magnussen, N., Mang, O., Meyer, H., Mirzoyan, R., Moralejo, A., Padilla, L., Panter, M., Plaga, R., Plyasheshnikov, A., Prahl, J., Pühlhofer, G., Rhode, W., Röhring, A., Rowell, G. P., Sahakian, V., Samorski, M., Schilling, M., Schröder, F., Siems, M., Stamm, W., Tluczykont, M., Völk, H. J., Wiedner, C. A., and Wittek, W.
- Abstract
Using the HEGRA system of imaging atmospheric Cherenkov telescopes, a region of the Galactic plane ($-10^\circ < b < 5^\circ$, $38^\circ < l < 43^\circ$) was surveyed for TeV gamma-ray emission, both from point sources and of diffuse nature. The region covered includes 15 known pulsars, 6 known supernova remnants (SNR) and one unidentified EGRET source. No evidence for emission from point sources was detected; upper limits are typically below 0.1 Crab units for the flux above 1 TeV. For the diffuse gamma-ray flux from the Galactic plane, an upper limit of $6.1\times10^{-15}$ph cm-2s-1sr-1MeV-1was derived under the assumption that the spatial distribution measured by the EGRET instrument extends to the TeV regime. This upper flux limit is a factor of about 1.5 larger than the flux expected from the ensemble of gamma-ray unresolved Galactic cosmic ray sources.
- Published
- 2001
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32. Rejection of the Hypothesis That Markarian 501 T[CLC]e[/CLC]V Photons Are Pure Bose-Einstein Condensates
- Author
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Aharonian, F., primary, Akhperjanian, A., additional, Barrio, J., additional, Bernlöhr, K., additional, Börst, H., additional, Bojahr, H., additional, Bolz, O., additional, Contreras, J., additional, Cortina, J., additional, Denninghoff, S., additional, Fonseca, V., additional, Gonzalez, J., additional, Götting, N., additional, Heinzelmann, G., additional, Hermann, G., additional, Heusler, A., additional, Hofmann, W., additional, Horns, D., additional, Ibarra, A., additional, Iserlohe, C., additional, Jung, I., additional, Kankanyan, R., additional, Kestel, M., additional, Kettler, J., additional, Kohnle, A., additional, Konopelko, A., additional, Kornmeyer, H., additional, Kranich, D., additional, Krawczynski, H., additional, Lampeitl, H., additional, Lorenz, E., additional, Lucarelli, F., additional, Magnussen, N., additional, Mang, O., additional, Meyer, H., additional, Mirzoyan, R., additional, Moralejo, A., additional, Padilla, L., additional, Panter, M., additional, Plaga, R., additional, Plyasheshnikov, A., additional, Prahl, J., additional, Pühlhofer, G., additional, Röhring, A., additional, Rhode, W., additional, Rowell, G., additional, Sahakian, V., additional, Samorski, M., additional, Schilling, M., additional, Schröder, F., additional, Siems, M., additional, Stamm, W., additional, Tluczykont, M., additional, Völk, H. J., additional, Wiedner, C. A., additional, and Wittek, W., additional
- Published
- 2000
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33. THE TIMING SYSTEM OF THE MAGIC TELESCOPE.
- Author
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Lucarelli, F., López, M., Oña-Wilhelmi, E., Fonseca, M. V., and Börst, H. G.
- Subjects
TELESCOPES ,GAMMA rays ,ELECTROMAGNETISM ,PULSARS ,PHOTONS ,RADIATION sources - Abstract
The Major Atmospheric Gamma-ray Imaging Čerenkov Telescope (MAGIC) will be the first ground-based Čerenkov telescope able to detect photons with E > 30 GeV. This region of the electromagnetic spectrum, yet unexplored, is fundamental for pulsar physics since theoretical models foreseen a cut-off in the pulsed emission at tens of GeV. In order to perform timing analysis of pulsars, accuracy below milliseconds in the time stamp of the detected event is needed. In this work, we present the timing system of the MAGIC telescope and the first timing analysis performed on real data. [ABSTRACT FROM AUTHOR]
- Published
- 2005
34. Simultaneous X-Ray and TeV Gamma-Ray Observation of the TeV Blazar Markarian 421 during 2000 February and May.
- Author
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Krawczynski, H., Sambruna, R., Kohnle, A., Coppi, P. S., Aharonian, F., Akhperjanian, A., Barrio, J., Bernlöhr, K., Börst, H., Bojahr, H., Bolz, O., Contreras, J., Cortina, J., Denninghoff, S., Fonseca, V., Gonzalez, J., Götting, N., Heinzelmann, G., Hermann, G., and Heusler, A.
- Published
- 2001
- Full Text
- View/download PDF
35. Ergebnisse der nichtinterventionellen PERSPECTIVES-Studie
- Author
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Felsenberg, D., Stege, U., Degner, C., Börst, H., and Bock, O.
- Published
- 2012
- Full Text
- View/download PDF
36. Impact of alfacalcidol on bone mineral density (pQCT & DXA) of radius, tibia, spine and hip in postmenopausal alendronate treated women with reduced bone mass
- Author
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Felsenberg, D., Bock, O., Boerst, H., Armbrecht, G., Beller, G., Degner, C., Schacht, E., Mazor, Z., Hashimoto, J., Martus, P., and Runge, M.
- Published
- 2009
- Full Text
- View/download PDF
37. The Crab Nebula and Pulsar between 500 GeV and 80 TeV: Observations with the HEGRA Stereoscopic Air Cerenkov Telescopes.
- Author
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Aharonian, F., Akhperjanian, A., Beilicke, M., Bernlöhr, K., Börst, H. -G, Bojahr, H., Bolz, O., Coarasa, T., Contreras, J. L., Cortina, J., Denninghoff, S., Fonseca, M. V., Girma, M., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., and Jung, I.
- Published
- 2004
- Full Text
- View/download PDF
38. The TeV Energy Spectrum of Markarian 501 Measured with the Stereoscopic Telescope System of HEGRA during 1998 and 1999.
- Author
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Aharonian, F., Akhperjanian, A., Barrio, J., Bernlöhr, K., Börst, H., Bojahr, H., Bolz, O., Contreras, J., Cortina, J., Denninghoff, S., Fonseca, V., Gonzalez, J., Götting, N., Heinzelmann, G., Hermann, G., Heusler, A., Hofmann, W., Horns, D., Iserlohe, C., and Ibarra, A.
- Published
- 2001
- Full Text
- View/download PDF
39. Volitional processes in changing physical activity: A randomized controlled trial with individuals with knee osteoarthritis.
- Author
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Lorbeer N, Schwarzer R, Keller J, Di Maio S, Domke A, Armbrecht G, Börst H, Martus P, Ertel W, Luszczynska A, and Knoll N
- Abstract
Objective: A health action process approach (HAPA)-based intervention was designed to support moderate-to-vigorous physical activity (MVPA) in individuals with osteoarthritis of the knee (OAK). In secondary analyses of the randomized controlled trial "preventing the impairment of primary osteoarthritis by high-impact long-term physical exercise regimen-psychological adherence program," we examined long-term effects of the intervention on HAPA determinants and MVPA, and explored the former as mediators of change., Method: N = 241 individuals with OAK (63% women, aged 44-80 years) were randomly assigned to the 12-month intervention condition (IC) or active control condition (CC). Between 2016 and 2020, self-reported HAPA determinants (action and coping planning, maintenance and recovery self-efficacy, action control) and collaborative planning were assessed at 0, 6, 12, 18, and 24 months, accelerometer-assessed MVPA at 0, 12, and 24 months. Multilevel and manifest path models were fit., Results: Compared to the CC, action planning was higher in the IC at 6, 12, and 24 months. Maintenance and recovery self-efficacy were stable in the IC but decreased in the CC. MVPA decreased in both conditions. More action planning in the IC at 12 months was related to higher MVPA at 24 months, but, as in all other models, the indirect effect was nonsignificant., Conclusions: The intervention partly stabilized or enhanced HAPA determinants but did not increase MVPA in a Western, highly-educated sample with OAK. Future work might use blended-care approaches enriched by mobile applications for continuous MVPA support. (PsycInfo Database Record (c) 2024 APA, all rights reserved).
- Published
- 2024
- Full Text
- View/download PDF
40. Enhancing physical activity and reducing symptoms of patients with osteoarthritis of the knee: a randomized controlled trial of the PrevOP-Psychological Adherence Program.
- Author
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Lorbeer N, Knoll N, Keller J, Domke A, Di Maio S, Armbrecht G, Börst H, Martus P, Ertel W, and Schwarzer R
- Subjects
- Humans, Female, Male, Exercise psychology, Pain, Self Efficacy, Telephone, Osteoarthritis, Knee therapy, Osteoarthritis, Knee psychology
- Abstract
Background: This primary analysis evaluated the "PREVenting the impairment of primary Osteoarthritis by high-impact long-term Physical exercise regimen-Psychological Adherence Program" (PrevOP-PAP), designed to support patients with osteoarthritis of the knee (OAK) to engage in regular moderate-to-vigorous physical activity (MVPA) to reduce OAK symptoms (WOMAC scores). Theory-based on the health action process approach (HAPA), the intervention targeted volitional precursors of MVPA change: action and coping planning, maintenance and recovery self-efficacy, action control, and social network formation. We hypothesized that compared to an active control condition, increases in MVPA at the end of the 12-month intervention would translate into lower WOMAC scores at 24 months in the intervention condition., Methods: Participants with radiographically verified moderate OAK (N = 241; 62.66% female; M(SD) = 65.60(7.61) years) were randomly assigned to the intervention (51%) or the active control condition. WOMAC scores (24 months) were the primary -, accelerometer-assessed MVPA (12 months) the key secondary outcomes. The PrevOP-PAP was a 12-month intervention with computer-assisted face-to-face and phone-based sessions designed to increase HAPA-proposed volitional precursors of MVPA change (up to 24 months; secondary outcomes). Intent-to-treat analyses included multiple regression and manifest path models., Results: MVPA (12 months) did not mediate effects of the PrevOP-PAP on WOMAC scores (24 months). Compared to the active control condition, WOMAC scores (24 months) were lower in the intervention condition, but this effect did not remain stable in sensitivity analyses (b(SE) = -8.41(4.66), 95%-CI [-17.53; 0.71]). However, exploratory analyses revealed significantly stronger reductions in WOMAC-pain (24 months) in the intervention condition (b(SE) = -2.99(1.18), 95%-CI [-5.36; -0.63]). Groups did not differ in MVPA at 12 months (b(SE) = -3.78(3.42), 95%-CI [-10.80; 2.58]). Of the proposed precursors of MVPA change, action planning was higher in the intervention than in the control condition (24 months; b(SE) = 0.64(0.26), 95%-CI [0.14; 1.15])., Conclusions: Compared to an active control condition, the PrevOP-PAP did not produce reliable effects on WOMAC scores and none on preceding MVPA. Of the HAPA-proposed volitional precursors, only action planning was sustainably increased. Future interventions should use m-health applications to digitally support long-term changes in proposed volitional precursors of MVPA change., Trial Registration: German Clinical Trials Register; https://drks.de/search/de/trial/DRKS00009677 ; also available at http://apps.who.int/trialsearch/ ; registration number: DRKS00009677; date of registration: 26/01/2016., (© 2023. The Author(s).)
- Published
- 2023
- Full Text
- View/download PDF
41. Balance Performance across the Lifespan Assessed by the Leonardo Mechanograph ® : A Cross-Sectional Study.
- Author
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Wiegmann S, Felsenberg D, Gast U, Börst H, Armbrecht G, and Dietzel R
- Abstract
Reference values of sway parameters have not been published for the Leonardo mechanograph
® so far. The aim of this cross-sectional study was to determine normative values on postural control measured by the force plate Leonardo Mechanograph® and to analyze the influence of age and sex on balance performance. A set of standardized standing positions with eyes opened (Romberg, semi-tandem, tandem, unipedal standing) was carried out. Analysis of covariance (ANCOVA) was used to detect age-and sex-related differences in center of pressure (COP) parameters (path length, velocity, elliptical area, anterior-posterior, and medio-lateral directions). Measurements were available for 570 subjects aged 20-86 years. Statistical analysis showed a high effect of age group on postural control (partial n² between 0.1 and 0.4) with a U-shaped dependency between postural control and age for all area- and path-related COP parameters, with the largest sway in the youngest (aged 20-40) and the oldest age group (aged 60-86). For velocity of COP, a linear deterioration with increasing age was found. Medio-lateral components of COP are likely to indicate the extent of postural control. Significant sex differences were not clearly supported by current findings. Age- and sex-related normative values are a useful resource for diagnostic, research, and training.- Published
- 2019
- Full Text
- View/download PDF
42. Greater association of peak neuromuscular performance with cortical bone geometry, bone mass and bone strength than bone density: A study in 417 older women.
- Author
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Belavý DL, Armbrecht G, Blenk T, Bock O, Börst H, Kocakaya E, Luhn F, Rantalainen T, Rawer R, Tomasius F, Willnecker J, and Felsenberg D
- Subjects
- Absorptiometry, Photon, Aged, Aged, 80 and over, Body Height, Body Weight, Bone and Bones diagnostic imaging, Bone and Bones physiology, Female, Hand Strength, Humans, Linear Models, Middle Aged, Organ Size, Principal Component Analysis, Tomography, X-Ray Computed, Bone Density physiology, Bone and Bones anatomy & histology, Motor Activity physiology, Muscles physiology
- Abstract
Background: We evaluated which aspects of neuromuscular performance are associated with bone mass, density, strength and geometry., Methods: 417 women aged 60-94years were examined. Countermovement jump, sit-to-stand test, grip strength, forearm and calf muscle cross-sectional area, areal bone mineral content and density (aBMC and aBMD) at the hip and lumbar spine via dual X-ray absorptiometry, and measures of volumetric vBMC and vBMD, bone geometry and section modulus at 4% and 66% of radius length and 4%, 38% and 66% of tibia length via peripheral quantitative computed tomography were performed. The first principal component of the neuromuscular variables was calculated to generate a summary neuromuscular variable. Percentage of total variance in bone parameters explained by the neuromuscular parameters was calculated. Step-wise regression was also performed., Results: At all pQCT bone sites (radius, ulna, tibia, fibula), a greater percentage of total variance in measures of bone mass, cortical geometry and/or bone strength was explained by peak neuromuscular performance than for vBMD. Sit-to-stand performance did not relate strongly to bone parameters. No obvious differential in the explanatory power of neuromuscular performance was seen for DXA aBMC versus aBMD. In step-wise regression, bone mass, cortical morphology, and/or strength remained significant in relation to the first principal component of the neuromuscular variables. In no case was vBMD positively related to neuromuscular performance in the final step-wise regression models., Conclusion: Peak neuromuscular performance has a stronger relationship with leg and forearm bone mass and cortical geometry as well as proximal forearm section modulus than with vBMD., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2016
- Full Text
- View/download PDF
43. Impact of oral ibandronate 150 mg once monthly on bone structure and density in post-menopausal osteoporosis or osteopenia derived from in vivo μCT.
- Author
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Bock O, Börst H, Beller G, Armbrecht G, Degner C, Martus P, Roth HJ, and Felsenberg D
- Subjects
- Absorptiometry, Photon, Administration, Oral, Aged, Biomarkers metabolism, Bone Diseases, Metabolic pathology, Bone and Bones metabolism, Bone and Bones pathology, Female, Humans, Ibandronic Acid, Middle Aged, Osteoporosis, Postmenopausal pathology, X-Ray Microtomography, Bone Density drug effects, Bone Density Conservation Agents therapeutic use, Bone Diseases, Metabolic drug therapy, Bone and Bones drug effects, Bone and Bones ultrastructure, Diphosphonates therapeutic use, Osteoporosis, Postmenopausal drug therapy
- Abstract
The effect of ibandronate 150 mg/once monthly in the treatment of post-menopausal osteopenia and osteoporosis on bone micro-structure at the distal tibia and radius has not been considered to date. Seventy post-menopausal women with osteoporosis or osteopenia were recruited. All subjects received calcium and vitamin D supplementation and were randomized to either a group which took 150 mg ibandronate oral monthly or a placebo group over a 12-month period. μCT measures of the distal tibia and radius were conducted every three months, with DXA lumbar spine and hip measurements conducted only pre and post and serum markers of bone formation and resorption measured every 6 months. After 12-months no significant impact of ibandronate on the primary outcome measures bone-volume to tissue-volume and trabecular separation at the distal tibia (p≥0.15) was found. Further multiple regression analyses of the primary end-points indicated a significant effect favoring the ibandronate intervention (p=0.045). Analysis of secondary end-points showed greater increases in distal tibia cortical thickness, cortical density and total density (p≤0.043) with ibandronate and no significant effects at the distal radius, but greater increases of hip DXA-BMD and lumbar spine DXA-BMD (p≤0.017). Ibandronate use resulted in a marked reduction in bone turnover (p<0.001). While ibandronate resulted in greater mineralization of bone, this effect differed from one body region to another. There was some impact of ibandronate on bone structure (cortical thickness) at the distal tibia, but not on bone-volume to tissue-volume or trabecular separation., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2012
- Full Text
- View/download PDF
44. Additive impact of alfacalcidol on bone mineral density and bone strength in alendronate treated postmenopausal women with reduced bone mass.
- Author
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Felsenberg D, Bock O, Börst H, Armbrecht G, Beller G, Degner C, Stephan-Oelkers M, Schacht E, Mazor Z, Hashimoto J, Roth HJ, Martus P, and Runge M
- Subjects
- Aged, Alendronate adverse effects, Bone Density physiology, Bone Density Conservation Agents adverse effects, Bone Resorption physiopathology, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Hydroxycholecalciferols adverse effects, Osteoporosis, Postmenopausal diagnostic imaging, Osteoporosis, Postmenopausal physiopathology, Radiography, Alendronate administration & dosage, Bone Density drug effects, Bone Density Conservation Agents administration & dosage, Bone Resorption drug therapy, Bone and Bones drug effects, Hydroxycholecalciferols administration & dosage, Osteoporosis, Postmenopausal drug therapy
- Abstract
Objectives: Assessment of additive impact of alfacalcidol 1 μg daily (Alfa) on bone mineral density (BMD) and on bone strength in postmenopausal women treated with alendronate 70 mg weekly + 500 mg calcium daily., Subjects and Methods: In a randomized, double-blind, placebo controlled study, 279 postmenopausal women with osteoporosis or osteopenia participated (intention to treat analysis [ITT]; aged 73.6∓4.7 years) and were treated with 70 mg alendronate (ALN) weekly and 500 mg calcium daily for 36 months. In addition, these patients received either 1 μg alfacalcidol (Alfa) or placebo (PLC) daily. BMD was measured with Dual-Energy-X-ray-Absorptiometry (DXA) at the lumbar spine and proximal femur and at forearm and tibia with peripheral quantitative computed tomography (pQCT) at regular intervals for 36 months., Results: DXA-BMD of lumbar spine (L1-4) increased after 36 months, by 6.65% (p<0.0001) in the Alfa/ALN group versus 4.17% (p<0.0001) in the PLC/ALN group. Group difference was significant after 3 years (p=0.026). At the end of the study, significant differences were found in favor of the Alfa/ALN group in trabecular density (tibia) (p=0.002), cortical density (midshaft tibia) (p=0.043), and bone strength (p=0.001). The remaining parameters showed no differences between the treatment arms, apart cortical bone density at midshaft radius., Conclusions: Alfacalcidol significantly increases the efficacy of alendronate treatment in osteopenic/osteoporotic postmenopausal women on spinal DXA-BMD, cortical and trabecular BMD of the tibia and also bending stiffness of the tibia.
- Published
- 2011
45. The 2nd Berlin BedRest Study: protocol and implementation.
- Author
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Belavý DL, Bock O, Börst H, Armbrecht G, Gast U, Degner C, Beller G, Soll H, Salanova M, Habazettl H, Heer M, de Haan A, Stegeman DF, Cerretelli P, Blottner D, Rittweger J, Gelfi C, Kornak U, and Felsenberg D
- Subjects
- Adult, Berlin, Humans, Male, Middle Aged, Osteoporosis etiology, Osteoporosis physiopathology, Osteoporosis prevention & control, Treatment Outcome, Vibration therapeutic use, Young Adult, Bed Rest adverse effects, Exercise Therapy methods, Physical Fitness physiology, Weightlessness Simulation adverse effects
- Abstract
Long-term bed-rest is used to simulate the effect of spaceflight on the human body and test different kinds of countermeasures. The 2nd Berlin BedRest Study (BBR2-2) tested the efficacy of whole-body vibration in addition to high-load resisitance exercise in preventing bone loss during bed-rest. Here we present the protocol of the study and discuss its implementation. Twenty-four male subjects underwent 60-days of six-degree head down tilt bed-rest and were randomised to an inactive control group (CTR), a high-load resistive exercise group (RE) or a high-load resistive exercise with whole-body vibration group (RVE). Subsequent to events in the course of the study (e.g. subject withdrawal), 9 subjects participated in the CTR-group, 7 in the RVE-group and 8 (7 beyond bed-rest day-30) in the RE-group. Fluid intake, urine output and axiallary temperature increased during bed-rest (p < .0001), though similarly in all groups (p > or = .17). Body weight changes differed between groups (p < .0001) with decreases in the CTR-group, marginal decreases in the RE-group and the RVE-group displaying significant decreases in body-weight beyond bed-rest day-51 only. In light of events and experiences of the current study, recommendations on various aspects of bed-rest methodology are also discussed.
- Published
- 2010
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