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1. Autorenverzeichnis

Author

Gesenhues, Stefan, primary, Gesenhues, Anne, additional, Bausewein, Claudia, additional, Bellm, Michaela, additional, Berndt, Peter, additional, Billenkamp, Ulrich, additional, Fobbe, Gabriele, additional, Grunert, Ingrid, additional, Heßbrügge, Martina, additional, Hausen, Thomas, additional, Horstmann, Thomas, additional, Keller, Martina, additional, Keller, Winfried, additional, Keth, Alexander, additional, Kremer-Zech, Herbert, additional, Kusch, Wolfgang, additional, Lang, Rüdiger, additional, Ledig, Thomas, additional, Nieß, Andreas, additional, Rieger, Martin, additional, Römer, Hermann Caspar, additional, Roller, Susanne, additional, Schmid, Thomas M., additional, Schmiedel, Stefan, additional, Sell, Stefan, additional, Voltz, Dr. med. Raymond, additional, Wahn, Matthias, additional, Wallmeyer, Stephan, additional, Weltermann, Birgitta, additional, Wiß,, Oliver, additional, Zappe, Helmut, additional, Domagalski, Lothar, additional, Hoffbauer, Gabi, additional, Kaup, Peter, additional, Kaup, Heike, additional, Kossat, Jutta, additional, Melms, Rolf, additional, Ott, Susann, additional, Richter†, Constanze, additional, Schönfelder, Heike, additional, Vetter-Höltershinken, Catherine, additional, Ziesché, Rainer H., additional, Bartels, Andrea, additional, Eissler, Manfred, additional, and Sandholzer, Hagen, additional

Published
2020
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2. Interim guidelines for the assessment and treatment of pain in children with multiple sclerosis

Author

Stratton, Catherine, primary, Vassilopoulos, Areti, additional, Brenton, J. Nicholas, additional, Potter, Kirsten, additional, Vargas, Wendy, additional, Rumm, Heather, additional, Bartels, Andrea, additional, Bailey, Mary, additional, Odonkor, Charles, additional, Stoll, Sharon, additional, Zempsky, E. William T., additional, Yeh, E. Ann, additional, and Makhani, Naila, additional

Published
2023
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4. Palliative Care Knowledge and Attitudes Among Patients With Neuroinflammatory Diseases.

Author

Ben-Zacharia, Aliza Bitton, Brugger, Helen T., Carbone, Stephanie, Malchiodi, Jena, Wallace, Eva, Bethoux, Francois, Volandes, Angelo, and Bartels, Andrea

Subjects
MULTIPLE sclerosis treatment, TREATMENT of neurodegeneration, STATISTICAL power analysis, SOCIAL support, CONFIDENCE intervals, CROSS-sectional method, SOCIAL networks, FAMILY support, SELF-evaluation, RESEARCH methodology, GOODNESS-of-fit tests, HEALTH literacy, PATIENTS' attitudes, NEUROINFLAMMATION, T-test (Statistics), QUESTIONNAIRES, COMMUNICATION, DESCRIPTIVE statistics, MEMORY disorders, RESEARCH funding, DECISION making in clinical medicine, PSYCHOLOGICAL adaptation, STATISTICAL sampling, PALLIATIVE treatment, NEUROMYELITIS optica, LONGITUDINAL method, GOAL (Psychology), EDUCATIONAL attainment, ATTITUDES toward death
Abstract

Background: Neuroinflammatory diseases are progressive leading to loss of function and disability. Although palliative care (PC) utilization has increased globally, it has scarcely increased in neurology. Objectives: To explore PC attitudes and knowledge among patients with neuroinflammatory diseases, such as multiple sclerosis, neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease. Methods: A cross-sectional 1-year study was conducted using the Palliative Care Knowledge Scale (PaCKS) and the PC Health Information National Trends Survey (HINTS). Murray's transition theory guided this study, which integrates palliative services including decision making, communication, and coordinated care. Results: The majority of study patients were female (69%) (N = 86) and White (79%). Forty-two percent indicated that they had never heard about PC, 46% said that they knew a little bit about PC, and 12% said that they knew a lot about PC. Fifty percent of patients knew the goals of PC and had knowledge about PC services. Forty-four percent to 60% agreed that PC goals include helping friends and family to cope with a patient's illness, offering social and emotional support, and managing pain and other symptoms. Patients who self-reported being familiar with PC performed significantly better on the PaCKS than those unfamiliar with PC (p < 0.001), and those who self-reported moderate or severe memory loss performed significantly worse on the PaCKS than those with mild memory loss (p = 0.027). There was an association between higher education and PC knowledge and between patients' PaCKS scores and their self-reported HINTS PC knowledge. Conclusions: Patients have partial PC knowledge. Patients require education about PC early in their disease along their illness trajectory. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Adressen

Author

Gesenhues, Stefan, primary, Ziesché, Rainer H., additional, Breetholt, Anne, additional, Bartels, Andrea, additional, Bausewein, Claudia, additional, Berndt, Peter, additional, Billenkamp, Ulrich, additional, Domagalski, Lothar, additional, Eissler, Manfred, additional, Grunert, Ingrid, additional, Hausen, Thomas, additional, Hermann, Martin, additional, Heßbrügge-Bekas, Martina, additional, Hoffbauer, Gabi, additional, Horstmann, Thomas, additional, Kaup, Heike, additional, Kaup, Peter, additional, Keller, Martina, additional, Keller, Winfried, additional, Keth, Alexander, additional, Kossat, Jutta, additional, Kremer-Zech, Herbert, additional, Ledig, Thomas, additional, Melms, Rolf, additional, Nieß, Andreas, additional, Ott, Susann, additional, Richter, Constanze, additional, Rieger, Martin, additional, Roller, Susanne, additional, Sandholzer, Hagen, additional, Schmid, Thomas, additional, Schmiedel, Stefan, additional, Schönfelder, Heike, additional, Sell, Stefan, additional, Vetter-Höltershinken, Catherin, additional, Voltz, Raymond, additional, Wahn, Matthias, additional, Wallmeyer, Stephan, additional, Weltermann, Birgitta, additional, Wiß, Oliver, additional, Zappe, Helmut A., additional, Ebert, Julia, additional, Engelhardt, Stephanie, additional, Huzenlaub, Martina, additional, Maile, Katja, additional, and Quellmann, Thomas, additional

Published
2014
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12. Guideline for the Assessment and Treatment of Pain in Children with Multiple Sclerosis (MS): A Delphi Panel (4328)

Author

Stratton, Catherine, primary, Bartels, Andrea, additional, Brenton, J. Nicholas, additional, Odonkor, Charles, additional, Potter, Kirsten, additional, Rumm, Heather, additional, Stoll, Sharon, additional, Vargas, Wendy, additional, Yeh, E. Ann, additional, Zempsky, William, additional, Makhani, Naila, additional, and Bailey, Mary, additional

Published
2021
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14. Autorenverzeichnis

Author

Gesenhues, Stefan, primary, Ziesché, Rainer H., additional, Bartels, Andrea, additional, Bausewein, Claudia, additional, Berndt, Peter, additional, Billenkamp, Ulrich, additional, Breetholt, Anne, additional, Domagalski, Lothar, additional, Ebert, Julia, additional, Eissler, Manfred, additional, Engelhardt, Stephanie, additional, Grunert, Ingrid, additional, Hermann, Martin, additional, Hoffbauer, Gabi, additional, Horstmann, Thomas, additional, Huzenlaub, Martina, additional, Kaup, Peter, additional, Keller, Martina, additional, Keller, Winfried, additional, Keth, Alexander, additional, Kossat, Jutta, additional, Kremer-Zech, Herbert, additional, Ledig, Thomas, additional, Nieß, Andreas, additional, Ott, Susann, additional, Piechowiak, Helmut, additional, Quellmann, Thomas, additional, Richter, Constanze, additional, Rieger, Martin, additional, Roller, Susanne, additional, Sandholzer, Hagen, additional, Schmid, Thomas, additional, Schmiedel, Stefan, additional, Schönfelder, Heike, additional, Sell, Stefan, additional, Vetter-Höltershinken, Catherin, additional, Voltz, Raymond, additional, Wahn, Matthias, additional, Wallmeyer, Stephan, additional, Weltermann, Birgitta, additional, Zappe, Helmut A., additional, Chrissafidou, Angeliki, additional, Dormann, Arno, additional, and Schoewe, Eva-Maria, additional

Published
2010
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17. Autorenverzeichnis

Author

Gesenhues, Stefan, primary, Ziesché, Rainer, additional, Bartels, Andrea, additional, Bausewein, Claudia, additional, Billenkamp, Ulrich, additional, Breetholt, Anne, additional, Chrissafidou, Angeliki, additional, Domagalski, Lothar, additional, Dormann, Arno, additional, Eissler, Manfred, additional, Engelhardt, Stephanie, additional, Grunert, Ingrid, additional, Haaker, Rolf, additional, Hermann, Martin, additional, Hoffbauer, Gabi, additional, Horstmann, Thomas, additional, Huzenlaub, Martina, additional, Keller, Martina, additional, Keller, Winfried, additional, Kossat, Jutta, additional, Kremer-Zech, Herbert, additional, Ledig, Thomas, additional, Maile, Katja, additional, Nieß, Andreas M., additional, Ott, Susann, additional, Piechowiak, Helmut, additional, Quellmann, Thomas, additional, Richter, Constanze, additional, Roller, Susanne, additional, Sandholzer, Hagen, additional, Schmid, Thomas, additional, Schoewe, Eva-Maria, additional, Schönfelder, Heike, additional, Sell, Stefan, additional, Wahn, Matthias, additional, Wallmeyer, Stephan, additional, Wiß, Oliver, additional, Zappe, Helmut, additional, Dickhuth, Hans-Hermann, additional, Hemmrich, Karen, additional, Hermann, Jörg, additional, von Hintzenstern, Krischan, additional, Rottleb, Christoph, additional, Schühle, Martin, additional, and Wagner, Jutta, additional

Published
2006
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23. Identification of gene expression patterns critically involved in experimental autoimmune encephalomyelitis and multiple sclerosis

Author

Weissert, Robert, Herrmann, Martin M., Barth, Silvia, Greve, Bernhard, Schumann, Kathrin M., and Bartels, Andrea

Subjects
ddc:610, MYELIN OLIGODENDROCYTE GLYCOPROTEIN, CELL-DERIVED FACTOR-1, CHEMOKINE RECEPTOR CXCR4, CYCLIC ADP-RIBOSE, PROTEIN-KINASE, T-CELLS, SIGNAL-TRANSDUCTION, LYMPHOID ORGANS, CD38, ACTIVATION, Experimental autoimmune encephalomyelitis, Multiple sclerosis, Central nervous system, Cellular traffic, T cell, Adjuvant, 610 Medizin
Abstract

After encounter with a central nervous system (CNS)-derived autoantigen, lymphocytes leave the lymph nodes and enter the CNS. This event leads only rarely to subsequent tissue damage. Genes relevant to CNS pathology after cell infiltration are largely undefined. Myelin-oligodendrocyte-glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS), a chronic autoimmune disease of the CNS that results in disability. To assess genes that are involved in encephalitogenicity and subsequent tissue damage mediated by CNS-infiltrating cells, we performed a DNA microarray analysis from cells derived from lymph nodes and eluted from CNS in LEW.1AV1 (RT1(av1)) rats immunized with MOG 91-108. The data was compared to immunizations with adjuvant alone or naive rats and to immunizations with the immunogenic but not encephalitogenic MOG 73-90 peptide. Here, we show involvement of Cd38, Cxcr4 and Akt and confirm these findings by the use of Cd38-knockout (B6.129P2-Cd38(tm1Lnd)/J) mice, S1P-receptor modulation during EAE and quantitative expression analysis in individuals with MS. The hereby-defined underlying pathways indicate cellular activation and migration pathways mediated by G-protein-coupled receptors as crucial events in CNS tissue damage. These pathways can be further explored for novel therapeutic interventions.

Published
2016

24. Praxisleitfaden Allgemeinmedizin

Author

Breetholt, Anee, Bartels, Andrea, Gesenhues, Stefan, Ziesche, Rainer, Breetholt, Anee, Bartels, Andrea, Gesenhues, Stefan, and Ziesche, Rainer

Subjects
Clinical medicine--Handbooks, manuals, etc
Abstract

Das Standardwerk der praktischen Hausarztmedizin Termin- und Kostendruck? Therapieren nach aktuellen Leitlinien? Der Praxisleitfaden Allgemeinmedizin zeigt Ihnen, wie Sie effizient, kompetent und evidenzbasiert arbeiten: alle Gebiete, alle Themen – direkt umsetzbar in die tägliche Praxismaximal kompakt, maximal übersichtlich Seit Jahren der bewährte Klassiker!

Published
2014

27. Untersuchungen zum Vorkommen von Verotoxin-bildenden Escherichia coli (VTEC) bei Rehwild in Hessen

Author

Bartels, Andrea Christine and Institut für Tierärztliche Nahrungsmittelkunde

Subjects
Verotoxin-bildende Escherichia coli, Prävalenz, ddc:630, Agriculture, Rehwild
Abstract

In einer repräsentativen Prävalenzstudie sollte für das Bundesland Hessen das Vorkommen von Verotoxin-bildenden E. coli (VTEC) bei Rehwild ermittelt werden. Dazu wurden Kotproben von 353 erlegten Rehen aus Revieren von 12 hessischen Forstämtern aus insgesamt 12 Landkreisen einbezogen. Nach selektiver kultureller Anreicherung wurden im Enzymimmunoassay (EIA) bzw. in einem immunchromatographischen Verfahren (Duopath®) Verotoxin-positiv getestete Proben weitergehend untersucht. Mittels konventioneller PCR und Anzüchtung der VTEC auf selektiv-elektiven Nährmedien konnten insgesamt 68 Tiere (19,3 %) als Ausscheider solcher Stämme nachgewiesen werden. Unter den positiven Rehen waren die juvenilen Tiere (29,84%) hoch signifikant (p < 0,001) häufiger betroffen als die beiden anderen Altersklassen „subadult“ (14,75 %) und „adult“ (12,80 %). Eine Abhängigkeit hinsichtlich des Geschlechts konnte nicht festgestellt werden. In Abhängigkeit von den Landkreisen gab es signifikante (p < 0,05) Unterschiede in den Prävalenzen (10,5 % - 41,4 %); in zwei Landkreisen konnten keine positiven Tiere nachgewiesen werden. Die molekular-basierte Typisierung zur Erfassung der Verotoxinsubtypen zeigte, dass der Subtyp 2b (38,5 %) dominierte, gefolgt von dem Subtypen VT 2g (30,8 %) sowie den Subtypen VT 1c, VT 1d (jeweils 12,8 %) und VT 1a (5,1 %). Von den insgesamt 68 positiven Rehen konnten 79 verschiedene E. coli-Isolate gewonnen werden. Bei sieben Tieren konnten neben verschiedenen Serotypen auch VTEC-Stämme mit unterschiedlichen Genkombinationen nachgewiesen werden. Lediglich ein VTEC-Isolat erwies sich als positiv für das E. coli attaching and effacing-Gen (eae), das regelmäßig bei hoch virulenten VTEC-Stämmen anzutreffen ist. Das Enterohämolysin-Gen konnte bei 27 Isolaten nachgewiesen werden. Unter den 79 Isolaten waren 27 verschiedene Serotypen zu finden. Am häufigsten wurden der Serotyp O21:H21(16,6 %) und O74:H28 (16,6 %) detektiert, gefolgt von O146:H28 (7,7 %), O154:H31(6,4 %) und O174:H8 (6,4 %). O174:H8 konnte in Zusammenhang mit den Verotoxin-Subtypen VT 1a und VT 1c sowie dem e-hly-Gen schon bei schweren Krankheitsverläufen des Menschen nachgewiesen werden. Insgesamt kann aufgrund der hier erhobenen Befunde davon ausgegangen werden, dass Rehwild in Hessen als natürliches Reservoir für VTEC angesehen werden muss. Prinzipiell handelt sich jedoch bei den isolierten VTEC-Stämmen vorwiegend um Stammformen mit geringer Virulenz. Zusätzlich deutet die Tatsache, dass VTEC aus Rehwild und landwirtschaftlichen Nutztieren Gemeinsamkeiten aufweisen und sich die Tierzahl pro landwirtschaftliche Fläche auf die Prävalenz auswirkt, auf eine wechselseitige Übertragung hin. In a representative prevalence study, the occurrence of verocytotoxin-producing E. coli should be determined for roe deer in the federal state of Hessen. For this purpose fecal samples from 353 shooted roe deer were included from 12 Hessian forestry offices of a total of 12 districts. After selective culture enrichment, verotoxin-positive samples were further analyzed in an enzyme immunoassay (EIA) or in an immunchromatographic method (Duopath®). By conventional PCR, and cultivation of VTEC on selective-elective culture media, a total of 68 animals (19.3%) were detected as shedders of such strains. Among the positive roe deer, the juvenile animals (29.84%) were highly significant (p < 0.001) more frequently affected than the other two age groups subadult (14.75%) and adult (12.80%); however, there were none gender differences. Depending on the districts, there were significant (p

Published
2014

33. Adressen

Author

Gesenhues, Stefan, Gesenhues, Anne, Weltermann, Birgitta, Bartels, Andrea, Bausewein, Claudia, Berndt, Peter, Billenkamp, Ulrich, Eissler, Manfred, Fobbe, Gabriele, Grunert, Ingrid, Heßbrügge, Martina, Hausen, Thomas, Horstmann, Thomas, Keller, Martina, Keller, Winfried, Keth, Alexander, Kossat, Jutta, Kremer-Zech, Herbert, Lang, Rüdiger, Ledig, Thomas, Nieß, Andreas, Rieger, Martin, Römer, Hermann Caspar, Roller, Susanne, Sandholzer, Hagen, Schmid, Thomas M., Schmiedel, Stefan, Sell, Stefan, Voltz, Raymond, Wahn, Matthias, Wallmeyer, Stephan, Wiß, Oliver, Zappe, Helmut, Domagalski, Lothar, Hoffbauer, Gabi, Kaup, Peter, Kaup, Heike, Melms, Rolf, Ott, Susann, Schönfelder, Heike, Vetter-Höltershinken, Catherine, Ziesché, Rainer H., and Richter, Constanze

Published
2018
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