5,014 results on '"Bartlett,John"'
Search Results
2. Geographic variation of mutagenic exposures in kidney cancer genomes
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Senkin, Sergey, Moody, Sarah, Díaz-Gay, Marcos, Abedi-Ardekani, Behnoush, Cattiaux, Thomas, Ferreiro-Iglesias, Aida, Wang, Jingwei, Fitzgerald, Stephen, Kazachkova, Mariya, Vangara, Raviteja, Le, Anh Phuong, Bergstrom, Erik N., Khandekar, Azhar, Otlu, Burçak, Cheema, Saamin, Latimer, Calli, Thomas, Emily, Atkins, Joshua Ronald, Smith-Byrne, Karl, Cortez Cardoso Penha, Ricardo, Carreira, Christine, Chopard, Priscilia, Gaborieau, Valérie, Keski-Rahkonen, Pekka, Jones, David, Teague, Jon W., Ferlicot, Sophie, Asgari, Mojgan, Sangkhathat, Surasak, Attawettayanon, Worapat, Świątkowska, Beata, Jarmalaite, Sonata, Sabaliauskaite, Rasa, Shibata, Tatsuhiro, Fukagawa, Akihiko, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Bartlett, John M. S., Albert, Monique, Phouthavongsy, Larry, Ashton-Prolla, Patricia, Botton, Mariana R., Silva Neto, Brasil, Bezerra, Stephania Martins, Curado, Maria Paula, Zequi, Stênio de Cássio, Reis, Rui Manuel, Faria, Eliney Ferreira, de Menezes, Nei Soares, Ferrari, Renata Spagnoli, Banks, Rosamonde E., Vasudev, Naveen S., Zaridze, David, Mukeriya, Anush, Shangina, Oxana, Matveev, Vsevolod, Foretova, Lenka, Navratilova, Marie, Holcatova, Ivana, Hornakova, Anna, Janout, Vladimir, Purdue, Mark P., Rothman, Nathaniel, Chanock, Stephen J., Ueland, Per Magne, Johansson, Mattias, McKay, James, Scelo, Ghislaine, Chanudet, Estelle, Humphreys, Laura, de Carvalho, Ana Carolina, Perdomo, Sandra, Alexandrov, Ludmil B., Stratton, Michael R., and Brennan, Paul
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- 2024
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3. A Novel Memory-Optimized Approach for Large-scale Peridynamics on the GPU
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Bartlett, John and Storti, Duane
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- 2023
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4. Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study
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Acs, Balazs, Leung, Samuel CY, Kidwell, Kelley M, Arun, Indu, Augulis, Renaldas, Badve, Sunil S, Bai, Yalai, Bane, Anita L, Bartlett, John MS, Bayani, Jane, Bigras, Gilbert, Blank, Annika, Buikema, Henk, Chang, Martin C, Dietz, Robin L, Dodson, Andrew, Fineberg, Susan, Focke, Cornelia M, Gao, Dongxia, Gown, Allen M, Gutierrez, Carolina, Hartman, Johan, Kos, Zuzana, Lænkholm, Anne-Vibeke, Laurinavicius, Arvydas, Levenson, Richard M, Mahboubi-Ardakani, Rustin, Mastropasqua, Mauro G, Nofech-Mozes, Sharon, Osborne, C Kent, Penault-Llorca, Frédérique M, Piper, Tammy, Quintayo, Mary Anne, Rau, Tilman T, Reinhard, Stefan, Robertson, Stephanie, Salgado, Roberto, Sugie, Tomoharu, van der Vegt, Bert, Viale, Giuseppe, Zabaglo, Lila A, Hayes, Daniel F, Dowsett, Mitch, Nielsen, Torsten O, and Rimm, David L
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Cancer ,Clinical Research ,Breast Cancer ,Biomarkers ,Tumor ,Biopsy ,Breast Neoplasms ,Female ,Humans ,Image Processing ,Computer-Assisted ,Immunohistochemistry ,Ki-67 Antigen ,Receptors ,Estrogen ,International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group ,Medical and Health Sciences ,Pathology - Abstract
Ki67 has potential clinical importance in breast cancer but has yet to see broad acceptance due to inter-laboratory variability. Here we tested an open source and calibrated automated digital image analysis (DIA) platform to: (i) investigate the comparability of Ki67 measurement across corresponding core biopsy and resection specimen cases, and (ii) assess section to section differences in Ki67 scoring. Two sets of 60 previously stained slides containing 30 core-cut biopsy and 30 corresponding resection specimens from 30 estrogen receptor-positive breast cancer patients were sent to 17 participating labs for automated assessment of average Ki67 expression. The blocks were centrally cut and immunohistochemically (IHC) stained for Ki67 (MIB-1 antibody). The QuPath platform was used to evaluate tumoral Ki67 expression. Calibration of the DIA method was performed as in published studies. A guideline for building an automated Ki67 scoring algorithm was sent to participating labs. Very high correlation and no systematic error (p = 0.08) was found between consecutive Ki67 IHC sections. Ki67 scores were higher for core biopsy slides compared to paired whole sections from resections (p ≤ 0.001; median difference: 5.31%). The systematic discrepancy between core biopsy and corresponding whole sections was likely due to pre-analytical factors (tissue handling, fixation). Therefore, Ki67 IHC should be tested on core biopsy samples to best reflect the biological status of the tumor.
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- 2022
5. Postoperative radiotherapy in women with early operable breast cancer (Scottish Breast Conservation Trial): 30-year update of a randomised, controlled, phase 3 trial
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Williams, Linda J, Kunkler, Ian H, Taylor, Karen J, Dunlop, Joanna, Piper, Tammy, Caldwell, Jacqueline, Jack, Wilma, Loane, Joseph F, Elder, Kenneth, Bartlett, John M S, Dixon, J Michael, and Cameron, David A
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- 2024
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6. Mobility gene expression differences among wild-type, Mmp20 null and Mmp20 over-expresser mice plus visualization of 3D mouse ameloblast directional movement
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Shin, Masashi, Matsushima, Aya, Nagao, Jun-ichi, Tanaka, Yoshihiko, Harada, Hidemitsu, Okabe, Koji, and Bartlett, John D.
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- 2023
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7. Metabolic syndrome among people living with HIV on antiretroviral therapy in Mwanza, Tanzania
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Malindisa, Evangelista, Balandya, Emmanuel, Njelekela, Marina, Kidenya, Benson R., Francis, Filbert, Mmbaga, Blandina T., Dika, Haruna, Lyamuya, Eligius, Sunguya, Bruno, Bartlett, John, and PrayGod, George
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- 2023
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8. Aromatase inhibition plus/minus Src inhibitor saracatinib (AZD0530) in advanced breast cancer therapy (ARISTACAT): a randomised phase II study
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Oswald, Ailsa J., Symeonides, Stefan N., Wheatley, Duncan, Chan, Stephen, Brunt, Adrian Murray, McAdam, Karen, Schmid, Peter, Waters, Simon, Poole, Christopher, Twelves, Chris, Perren, Timothy, Bartlett, John, Piper, Tammy, Chisholm, Eve Macdonald, Welsh, Michelle, Hill, Robert, Hopcroft, Lisa E. M., Barrett-Lee, Peter, and Cameron, David A.
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- 2023
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9. Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients.
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Yau, Christina, Osdoit, Marie, van der Noordaa, Marieke, Shad, Sonal, Wei, Jane, de Croze, Diane, Hamy, Anne-Sophie, Laé, Marick, Reyal, Fabien, Sonke, Gabe S, Steenbruggen, Tessa G, van Seijen, Maartje, Wesseling, Jelle, Martín, Miguel, Del Monte-Millán, Maria, López-Tarruella, Sara, I-SPY 2 Trial Consortium, Boughey, Judy C, Goetz, Matthew P, Hoskin, Tanya, Gould, Rebekah, Valero, Vicente, Edge, Stephen B, Abraham, Jean E, Bartlett, John MS, Caldas, Carlos, Dunn, Janet, Earl, Helena, Hayward, Larry, Hiller, Louise, Provenzano, Elena, Sammut, Stephen-John, Thomas, Jeremy S, Cameron, David, Graham, Ashley, Hall, Peter, Mackintosh, Lorna, Fan, Fang, Godwin, Andrew K, Schwensen, Kelsey, Sharma, Priyanka, DeMichele, Angela M, Cole, Kimberly, Pusztai, Lajos, Kim, Mi-Ok, van 't Veer, Laura J, Esserman, Laura J, and Symmans, W Fraser
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I-SPY 2 Trial Consortium ,Humans ,Breast Neoplasms ,Neoplasm ,Residual ,Receptor ,erbB-2 ,Chemotherapy ,Adjuvant ,Neoadjuvant Therapy ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Middle Aged ,Female ,Young Adult ,Receptor ,ErbB-2 ,Breast Cancer ,Patient Safety ,Clinical Research ,Cancer ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BackgroundPrevious studies have independently validated the prognostic relevance of residual cancer burden (RCB) after neoadjuvant chemotherapy. We used results from several independent cohorts in a pooled patient-level analysis to evaluate the relationship of RCB with long-term prognosis across different phenotypic subtypes of breast cancer, to assess generalisability in a broad range of practice settings.MethodsIn this pooled analysis, 12 institutes and trials in Europe and the USA were identified by personal communications with site investigators. We obtained participant-level RCB results, and data on clinical and pathological stage, tumour subtype and grade, and treatment and follow-up in November, 2019, from patients (aged ≥18 years) with primary stage I-III breast cancer treated with neoadjuvant chemotherapy followed by surgery. We assessed the association between the continuous RCB score and the primary study outcome, event-free survival, using mixed-effects Cox models with the incorporation of random RCB and cohort effects to account for between-study heterogeneity, and stratification to account for differences in baseline hazard across cancer subtypes defined by hormone receptor status and HER2 status. The association was further evaluated within each breast cancer subtype in multivariable analyses incorporating random RCB and cohort effects and adjustments for age and pretreatment clinical T category, nodal status, and tumour grade. Kaplan-Meier estimates of event-free survival at 3, 5, and 10 years were computed for each RCB class within each subtype.FindingsWe analysed participant-level data from 5161 patients treated with neoadjuvant chemotherapy between Sept 12, 1994, and Feb 11, 2019. Median age was 49 years (IQR 20-80). 1164 event-free survival events occurred during follow-up (median follow-up 56 months [IQR 0-186]). RCB score was prognostic within each breast cancer subtype, with higher RCB score significantly associated with worse event-free survival. The univariable hazard ratio (HR) associated with one unit increase in RCB ranged from 1·55 (95% CI 1·41-1·71) for hormone receptor-positive, HER2-negative patients to 2·16 (1·79-2·61) for the hormone receptor-negative, HER2-positive group (with or without HER2-targeted therapy; p
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- 2022
10. The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
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El Bairi, Khalid, Haynes, Harry R, Blackley, Elizabeth, Fineberg, Susan, Shear, Jeffrey, Turner, Sophia, de Freitas, Juliana Ribeiro, Sur, Daniel, Amendola, Luis Claudio, Gharib, Masoumeh, Kallala, Amine, Arun, Indu, Azmoudeh-Ardalan, Farid, Fujimoto, Luciana, Sua, Luz F, Liu, Shi-Wei, Lien, Huang-Chun, Kirtani, Pawan, Balancin, Marcelo, El Attar, Hicham, Guleria, Prerna, Yang, Wenxian, Shash, Emad, Chen, I-Chun, Bautista, Veronica, Do Prado Moura, Jose Fernando, Rapoport, Bernardo L, Castaneda, Carlos, Spengler, Eunice, Acosta-Haab, Gabriela, Frahm, Isabel, Sanchez, Joselyn, Castillo, Miluska, Bouchmaa, Najat, Md Zin, Reena R, Shui, Ruohong, Onyuma, Timothy, Yang, Wentao, Husain, Zaheed, Willard-Gallo, Karen, Coosemans, An, Perez, Edith A, Provenzano, Elena, Ericsson, Paula Gonzalez, Richardet, Eduardo, Mehrotra, Ravi, Sarancone, Sandra, Ehinger, Anna, Rimm, David L, Bartlett, John MS, Viale, Giuseppe, Denkert, Carsten, Hida, Akira I, Sotiriou, Christos, Loibl, Sibylle, Hewitt, Stephen M, Badve, Sunil, Symmans, William Fraser, Kim, Rim S, Pruneri, Giancarlo, Goel, Shom, Francis, Prudence A, Inurrigarro, Gloria, Yamaguchi, Rin, Garcia-Rivello, Hernan, Horlings, Hugo, Afqir, Said, Salgado, Roberto, Adams, Sylvia, Kok, Marleen, Dieci, Maria Vittoria, Michiels, Stefan, Demaria, Sandra, and Loi, Sherene
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Immunology ,Breast Cancer ,Cancer ,Clinical Research ,4.1 Discovery and preclinical testing of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,International Immuno-Oncology Biomarker Working Group ,Clinical sciences ,Oncology and carcinogenesis ,Epidemiology - Abstract
The advent of immune-checkpoint inhibitors (ICI) in modern oncology has significantly improved survival in several cancer settings. A subgroup of women with breast cancer (BC) has immunogenic infiltration of lymphocytes with expression of programmed death-ligand 1 (PD-L1). These patients may potentially benefit from ICI targeting the programmed death 1 (PD-1)/PD-L1 signaling axis. The use of tumor-infiltrating lymphocytes (TILs) as predictive and prognostic biomarkers has been under intense examination. Emerging data suggest that TILs are associated with response to both cytotoxic treatments and immunotherapy, particularly for patients with triple-negative BC. In this review from The International Immuno-Oncology Biomarker Working Group, we discuss (a) the biological understanding of TILs, (b) their analytical and clinical validity and efforts toward the clinical utility in BC, and (c) the current status of PD-L1 and TIL testing across different continents, including experiences from low-to-middle-income countries, incorporating also the view of a patient advocate. This information will help set the stage for future approaches to optimize the understanding and clinical utilization of TIL analysis in patients with BC.
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- 2021
11. Protocol for pragmatic randomised trial: integrating electronic health record-based behavioural economic ‘nudges’ into the electronic health record to reduce preoperative testing for patients undergoing cataract surgery
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Ahmadi, Alast, Sorensen, Andrea, Villaflores, Chad Wes A, Mafi, John N, Vangala, Sitaram S, Hofer, Ira S, Bartlett, John D, Cheng, Eric M, Duval, Victor F, Damberg, Cheryl, Elashoff, David, Goldstein, Noah J, Ladapo, Joseph A, Moore, James M, Pessegueiro, Antonio M, Shu, Suzanne B, Skootsky, Samuel A, Turner, Ashley, and Sarkisian, Catherine A
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Health Services and Systems ,Biomedical and Clinical Sciences ,Health Sciences ,Clinical Research ,Prevention ,Patient Safety ,Comparative Effectiveness Research ,Clinical Trials and Supportive Activities ,Good Health and Well Being ,Cataract ,Cataract Extraction ,Economics ,Behavioral ,Electronic Health Records ,Humans ,Low-Value Care ,Randomized Controlled Trials as Topic ,quality in health care ,cataract and refractive surgery ,health economics ,anaesthesia in ophthalmology ,geriatric medicine ,Clinical Sciences ,Public Health and Health Services ,Other Medical and Health Sciences ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
IntroductionRobust randomised trial data have shown that routine preoperative (pre-op) testing for cataract surgery patients is inappropriate. While guidelines have discouraged testing since 2002, cataract pre-op testing rates have remained unchanged since the 1990s. Given the challenges of reducing low-value care despite strong consensus around the evidence, innovative approaches are needed to promote high-value care. This trial evaluates the impact of an interdisciplinary electronic health record (EHR) intervention that is informed by behavioural economic theory.Methods and analysisThis pragmatic randomised trial is being conducted at UCLA Health between June 2021 and June 2022 with a 12-month follow-up period. We are randomising all UCLA Health physicians who perform pre-op visits during the study period to one of the three nudge arms or usual care. These three nudge alerts address (1) patient harm, (2) increased out-of-pocket costs for patients and (3) psychological harm to the patients related to pre-op testing. The nudges are triggered when a physician starts to order a pre-op test. We hypothesise that receipt of a nudge will be associated with reduced pre-op testing. The primary outcome will be the change in the percentage of patients undergoing pre-op testing at 12 months. Secondary outcomes will include the percentage of patients undergoing specific categories of pre-op tests (labs, EKGs, chest X-rays (CXRs)), the efficacy of each nudge, same-day surgery cancellations and cost savings.Ethics and disseminationThe study protocol was approved by the institutional review board of the University of California, Los Angeles as well as a nominated Data Safety Monitoring Board. If successful, we will have created a tool that can be disseminated rapidly to EHR vendors across the nation to reduce inappropriate testing for the most common low-risk surgical procedures in the country.Trial registration numberClinicalTrials.gov identifier: NCT04104256.
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- 2021
12. Preparation and Characterisation of Sol-Gel Derived Zirconia Coatings
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Anast, Maree, primary, Ben-Nissan, Besim, additional, Bartlett, John R., additional, Woolfrey, Jim L., additional, Bell, John M., additional, Bell, Trevor J., additional, De Villiers, Dan R., additional, Spiccia, Leone, additional, West, Bruce O., additional, Johnston, Graham R., additional, and Watkins, Ian D., additional
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- 2023
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13. Comparative survival analysis of multiparametric tests-when molecular tests disagree-A TEAM Pathology study.
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Bartlett, John MS, Bayani, Jane, Kornaga, Elizabeth, Xu, Keying, Pond, Greg R, Piper, Tammy, Mallon, Elizabeth, Yao, Cindy Q, Boutros, Paul C, Hasenburg, Annette, Dunn, JA, Markopoulos, Christos, Dirix, Luc, Seynaeve, Caroline, van de Velde, Cornelis JH, Stein, Robert C, and Rea, Daniel
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Cancer ,Breast Cancer ,4.2 Evaluation of markers and technologies ,4.1 Discovery and preclinical testing of markers and technologies - Abstract
Multiparametric assays for risk stratification are widely used in the management of both node negative and node positive hormone receptor positive invasive breast cancer. Recent data from multiple sources suggests that different tests may provide different risk estimates at the individual patient level. The TEAM pathology study consists of 3284 postmenopausal ER+ve breast cancers treated with endocrine therapy Using genes comprising the following multi-parametric tests OncotypeDx®, Prosigna™ and MammaPrint® signatures were trained to recapitulate true assay results. Patients were then classified into risk groups and survival assessed. Whilst likelihood χ2 ratios suggested limited value for combining tests, Kaplan-Meier and LogRank tests within risk groups suggested combinations of tests provided statistically significant stratification of potential clinical value. Paradoxically whilst Prosigna-trained results stratified Oncotype-trained subgroups across low and intermediate risk categories, only intermediate risk Prosigna-trained cases were further stratified by Oncotype-trained results. Both Oncotype-trained and Prosigna-trained results further stratified MammaPrint-trained low risk cases, and MammaPrint-trained results also stratified Oncotype-trained low and intermediate risk groups but not Prosigna-trained results. Comparisons between existing multiparametric tests are challenging, and evidence on discordance between tests in risk stratification presents further dilemmas. Detailed analysis of the TEAM pathology study suggests a complex inter-relationship between test results in the same patient cohorts which requires careful evaluation regarding test utility. Further prognostic improvement appears both desirable and achievable.
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- 2021
14. Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials
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Taylor, Carolyn, Dodwell, David, McGale, Paul, Hills, Robert K, Berry, Richard, Bradley, Rosie, Braybrooke, Jeremy, Clarke, Mike, Gray, Richard, Holt, Francesca, Liu, Zulian, Pan, Hongchao, Peto, Richard, Straiton, Ewan, Coles, Charlotte, Duane, Fran, Hennequin, Christophe, Jones, Glenn, Kühn, Thorsten, Oliveros, Sileida, Overgaard, Jens, Pritchard, Kathy I, Suh, Chang-Ok, Beake, Graham, Boddington, Clare, Davies, Christina, Davies, Lucy, Evans, Vaughan, Gay, Jo, Gettins, Lucy, Godwin, Jon, James, Sam, Kerr, Amanda, Liu, Hui, MacKinnon, Elizabeth, Mannu, Gurdeep, McHugh, Theresa, Morris, Philip, Nakahara, Mariko, Read, Simon, Taylor, Hannah, Ferguson, John, Scheurlen, Hans, Zurrida, Stefano, Galimberti, Viviana, Ingle, James, Valagussa, Pinuccia, Veronesi, Umberto, Anderson, Stewart, Tang, Gong, Fisher, Bernard, Fossa, Sophie, Valborg Reinertsen, Kristin, Host, Herman, Muss, Hyman, Holli, Kaija, Albain, Kathy, Arriagada, Rodrigo, Bartlett, John, Bergsten-Nordström, Elizabeth, Bliss, Judith, Brain, Etienne, Carey, Lisa, Coleman, Robert, Cuzick, Jack, Davidson, Nancy, Del Mastro, Lucia, Di Leo, Angelo, Dignam, James, Dowsett, Mitch, Ejlertsen, Bent, Francis, Prue, García-Sáenz, José Angel, Gelber, Rich, Gnant, Michael, Goetz, Matthew, Goodwin, Pam, Halpin-Murphy, Pat, Hayes, Dan, Hill, Catherine, Jagsi, Reshma, Janni, Wolfgang, Loibl, Sibylle, Mamounas, Eleftherios, Martín, Miguel, McIntosh, Stuart, Mukai, Hirofumi, Nekljudova, Valentina, Norton, Larry, Ohashi, Yasuo, Piccart, Martine, Pierce, Lori, Raina, Vinod, Rea, Daniel, Regan, Meredith, Robertson, John, Rutgers, Emiel, Salgado, Roberto, Slamon, Dennis, Spanic, Tanja, Sparano, Joseph, Steger, Guenther, Toi, Masakazu, Tutt, Andrew, Viale, Giuseppe, Wang, Xiang, Wilcken, Nicholas, Wolmark, Norman, Yu, Ke-Da, Cameron, David, Bergh, Jonas, Swain, Sandra, Whelan, Tim, and Poortmans, Philip
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- 2023
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15. Multicenter Analysis of Electronic Health Record Use among Ophthalmologists
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Baxter, Sally L, Gali, Helena E, Mehta, Mitul C, Rudkin, Scott E, Bartlett, John, Brandt, James D, Sun, Catherine Q, Millen, Marlene, and Longhurst, Christopher A
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Electronic Health Records ,Humans ,Ophthalmologists ,Ophthalmology ,United States ,Clinical Sciences ,Opthalmology and Optometry ,Public Health and Health Services ,Ophthalmology & Optometry ,Ophthalmology and optometry - Abstract
Order entry via mobile client was associated with decreased after-hours EHR use in a cohort of 139 academic ophthalmologists. EHR audit log data can provide insights into strategies for optimizing efficiency of EHR use.
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- 2021
16. Decision support tool for the construction and seasonal operation of farm-scale anaerobic digestion plants
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O'Connor, Seán, Ehimen, Ehiaze, Pillai, Suresh C., Lyons, Gary, Johnston, Chris, Wills, Michael, and Bartlett, John
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- 2023
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17. Improving Cancer Care for People Living With HIV: A Qualitative Study of Provider Knowledge, Attitudes, and Practice
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Henry, Valencia, Stephens, Maya J., Galyean, Patrick, Young, Jeanette, Zickmund, Susan, Knettel, Brandon A., Bartlett, John, Watt, Melissa H., Pollak, Kathryn I., Ubel, Peter A., Fagerlin, Angela, and Suneja, Gita
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- 2023
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18. Trifocal intraocular lenses versus bifocal intraocular lenses after cataract extraction among participants with presbyopia
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Zamora-de La Cruz, Diego, Zúñiga-Posselt, Karla, Bartlett, John, Gutierrez, Mario, and Abariga, Samuel A
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Biomedical and Clinical Sciences ,Ophthalmology and Optometry ,Aging ,Clinical Trials and Supportive Activities ,Clinical Research ,Eye Disease and Disorders of Vision ,Neurosciences ,Eye ,Capsule Opacification ,Cataract Extraction ,Confidence Intervals ,Contrast Sensitivity ,Female ,Humans ,Lens Implantation ,Intraocular ,Male ,Middle Aged ,Multifocal Intraocular Lenses ,Postoperative Complications ,Presbyopia ,Time Factors ,Visual Acuity ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,General & Internal Medicine ,Biomedical and clinical sciences ,Health sciences - Abstract
BackgroundPresbyopia occurs when the lens of the eyes loses its elasticity leading to loss of accommodation. The lens may also progress to develop cataract, affecting visual acuity and contrast sensitivity. One option of care for individuals with presbyopia and cataract is the use of multifocal or extended depth of focus intraocular lens (IOL) after cataract surgery. Although trifocal and bifocal IOLs are designed to restore three and two focal points respectively, trifocal lens may be preferable because it restores near, intermediate, and far vision, and may also provide a greater range of useful vision and allow for greater spectacle independence in individuals with presbyopia.ObjectivesTo assess the effectiveness and safety of implantation with trifocal versus bifocal IOLs during cataract surgery among participants with presbyopia.Search methodsWe searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Trials Register) (2019, Issue 9); Ovid MEDLINE; Embase.com; PubMed; ClinicalTrials.gov; and the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP). We did not use any date or language restrictions in the electronic search for trials. We last searched the electronic databases on 26 September 2019. We searched the reference lists of the retrieved articles and the abstracts from the Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO) for the years 2005 to 2015.Selection criteriaWe included randomized controlled trials that compared trifocal and bifocal IOLs among participants 30 years or older with presbyopia undergoing cataract surgery.Data collection and analysisWe used standard Cochrane methodology.Main resultsWe identified five studies conducted in Europe with a total of 175 participants. All five studies assessed uncorrected distance visual acuity (primary outcome of the review), while some also examined our secondary outcomes including uncorrected near, intermediate, and best-corrected distance visual acuity, as well as contrast sensitivity. Study characteristics All participants had bilateral cataracts with no pre-existing ocular pathologies or ocular surgery. Participants' mean age ranged from 58 to 64 years. Only one study reported on gender of participants, and they were mostly women. We assessed all the included studies as being at unclear risk of bias for most domains. Two studies received financial support from manufacturers of lenses evaluated in this review, and at least one author of another study reported receiving payments for delivering lectures with lens manufacturers. Findings All studies compared trifocal versus bifocal IOL implantation on visual acuity outcomes measured on a LogMAR scale. At one year, trifocal IOL showed no evidence of effect on uncorrected distance visual acuity (mean difference (MD) 0.00, 95% confidence interval (CI) -0.04 to 0.04; I2 = 0%; 2 studies, 107 participants; low-certainty evidence) and uncorrected near visual acuity (MD 0.01, 95% CI -0.04 to 0.06; I2 = 0%; 2 studies, 107 participants; low-certainty evidence). Trifocal IOL implantation may improve uncorrected intermediate visual acuity at one year (MD -0.16, 95% CI -0.22 to -0.10; I2= 0%; 2 studies, 107 participants; low-certainty evidence), but showed no evidence of effect on best-corrected distance visual acuity at one year (MD 0.00, 95% CI -0.03 to 0.04; I2= 0%; 2 studies, 107 participants; low-certainty evidence). No study reported on contrast sensitivity or quality of life at one-year follow-up. Data from one study at three months suggest that contrast sensitivity did not differ between groups under photopic conditions, but may be worse in the trifocal group in one of the four frequencies under mesopic conditions (MD -0.19, 95% CI -0.33 to -0.05; 1 study; I2 = 0%, 25 participants; low-certainty evidence). In two studies, the investigators observed that participants' satisfaction or spectacle independence may be higher in the trifocal group at six months, although another study found no evidence of a difference in participant satisfaction or spectacle independence between groups. Adverse events Adverse events reporting varied among studies. Two studies reported information on adverse events at one year. One study reported that participants showed no intraoperative or postoperative complications, while the other study reported that four eyes (11.4%) in the bifocal and three eyes (7.5%) in the trifocal group developed significant posterior capsular opacification requiring YAG capsulotomy. The certainty of the evidence was low.Authors' conclusionsThere is low-certainty of evidence that compared to bifocal IOL, implantation of trifocal IOL may improve uncorrected intermediate visual acuity at one year. However, there is no evidence of a difference between trifocal and bifocal IOL for uncorrected distance visual acuity, uncorrected near visual acuity, and best-corrected visual acuity at one year. Future research should include the comparison of both trifocal IOL and specific bifocal IOLs that correct intermediate visual acuity to evaluate important outcomes such as contrast sensitivity and quality of life.
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- 2020
19. Computational approaches to support comparative analysis of multiparametric tests: Modelling versus Training
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Bartlett, John MS, Bayani, Jane, Kornaga, Elizabeth N, Danaher, Patrick, Crozier, Cheryl, Piper, Tammy, Yao, Cindy Q, Dunn, Janet A, Boutros, Paul C, and Stein, Robert C
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Health Services and Systems ,Health Sciences ,Health Services ,Breast Cancer ,Clinical Research ,Cancer ,Prevention ,Detection ,screening and diagnosis ,4.1 Discovery and preclinical testing of markers and technologies ,Good Health and Well Being ,Breast Neoplasms ,Computer Simulation ,Cost-Benefit Analysis ,Female ,Gene Expression Profiling ,Genomics ,Humans ,Prognosis ,Randomized Controlled Trials as Topic ,OPTIMA Trial Management Group ,General Science & Technology - Abstract
Multiparametric assays for risk stratification are widely used in the management of breast cancer, with applications being developed for a number of other cancer settings. Recent data from multiple sources suggests that different tests may provide different risk estimates at the individual patient level. There is an increasing need for robust methods to support cost effective comparisons of test performance in multiple settings. The derivation of similar risk classifications using genes comprising the following multi-parametric tests Oncotype DX® (Genomic Health.), Prosigna™ (NanoString Technologies, Inc.), MammaPrint® (Agendia Inc.) was performed using different computational approaches. Results were compared to the actual test results. Two widely used approaches were applied, firstly computational "modelling" of test results using published algorithms and secondly a "training" approach which used reference results from the commercially supplied tests. We demonstrate the potential for errors to arise when using a "modelling" approach without reference to real world test results. Simultaneously we show that a "training" approach can provide a highly cost-effective solution to the development of real-world comparisons between different multigene signatures. Comparisons between existing multiparametric tests is challenging, and evidence on discordance between tests in risk stratification presents further dilemmas. We present an approach, modelled in breast cancer, which can provide health care providers and researchers with the potential to perform robust and meaningful comparisons between multigene tests in a cost-effective manner. We demonstrate that whilst viable estimates of gene signatures can be derived from modelling approaches, in our study using a training approach allowed a close approximation to true signature results.
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- 2020
20. Robust Modeling of Acoustic Phonon Transmission in Nanomechanical Structures
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Bartlett, John, Rostem, Karwan, and Wollack, Edward
- Subjects
Physics - Applied Physics ,Physics - Instrumentation and Detectors - Abstract
The transmission of acoustic phonons is an important element in the design and performance of nano-mechanical devices operating in the mesoscopic limit. Analytic expressions for the power transmission coefficient, T, exist only in the low-frequency (quasi-static) limit described by thin-plate elastic theory, and for well-defined elastic wave-guiding geometries. We compare two numerical techniques based on finite-element computations to determine the frequency dependence of T for arbitrary phonon scattering structures. Both methods take into account acoustic mode conversion to acoustic and optical modes. In one case, phase and amplitude of complex-valued reflected waves are determined and related to transmission through a Fresnel equation, while in the other the magnitude of the transmitted mechanical power is directly calculated. The numerical robustness of these methods is demonstrated by considering the transmission across an abrupt junction in a rectangular elastic beam, a well-known problem of considerable importance in mesoscopic device physics. The simulations presented extend the standard results for acoustic phonon transmission at an abrupt junction, and are in good agreement with analytic predictions from thin-plate elastic theory in the long-wavelength limit. More generally, the numerical methods developed provide an effective tool for calculating acoustic mode energy loss in nano-mechanical resonators through mode conversion and heat transfer in arbitrary mesoscopic structures., Comment: 5 pages, 5 figures
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- 2018
- Full Text
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21. Anthracycline-containing and taxane-containing chemotherapy for early-stage operable breast cancer: a patient-level meta-analysis of 100 000 women from 86 randomised trials
- Author
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Braybrooke, Jeremy, Bradley, Rosie, Gray, Richard, Hills, Robert K, Pan, Hongchao, Peto, Richard, Dodwell, David, McGale, Paul, Taylor, Carolyn, Aihara, Tomohiko, Anderson, Stewart, Blum, Joanne, Cardoso, Fatima, Chen, Xiaosong, Crown, John P, Ejlertsen, Bent, Friedl, Thomas W P, Harbeck, Nadia, Janni, Wolfgang, Jensen, Maj-Britt, Mamounas, Eleftherios, Narui, Kazutaka, Nitz, Ulrike, Norton, Larry, O'Shaughnessy, Joyce, Piccart, Martine, Robert, Nicholas, Shao, Zhi-Ming, Slamon, Dennis, Sparano, Joseph, Watanabe, Toru, Yothers, Greg, Yu, Ke-Da, Berry, Richard, Boddington, Clare, Clarke, Mike, Davies, Christina, Davies, Lucy, Duane, Fran, Evans, Vaughan, Gay, Jo, Gettins, Lucy, Godwin, Jon, James, Sam, Lui, Hui, Lui, Zulian, MacKinnon, Elizabeth, Mannu, Gurdeep, McHugh, Theresa, Morris, Philip, Read, Simon, Straiton, Ewan, Buzdar, Aman, Suman, Vera J, Hunt, Kelly K, Leonard, Robert C F, Mansi, Janine, Delbaldo, Catherine, Piedbois, Pascal, Quinaux, Emmanuel, Fesl, Christian, Gnant, Michael, Sölkner, Lidija, Steger, Guenther, Eikesdal, Hans Petter, Lønning, Per Eystein, Bee, Valerie, Fung, Helena, Mackey, John, Martin, Miguel, Press, Michael, De Azambuja, Evandro, Gelber, Richard, Regan, Meredith, Di Leo, Angelo, Van Dooren, Veerle, Nogaret, Jean Marie, Bartlett, John, Chen, Bingshu E, Gelmon, Karen, Goss, Paul E, Levine, Mark N, Parulekar, Wendy, Pritchard, Kathleen I, Shepherd, Lois, Berry, Donald, Cirrincione, Constance, Shulman, Lawrence N, Winer, Eric, Gelman, Rebecca S, Harris, Jay R, Henderson, Craig, Shapiro, Charles L, Christiansen, Peer, Ewertz, Marianne, Mouridsen, Henning T, Van Leeuwen, Elise, Linn, Sabine, Van Rossum, Annelot G J, Van Tinteren, Harm, Van Werkhoven, Erik, Goldstein, Lori, Gray, Robert, Eiermann, Wolfgang, Gianni, Luca, Valagussa, Pinuccia, Bogaerts, Jan, Bonnefoi, Herve, Poncet, Coralie, Huovinen, Riikka, Joensuu, Heikki, Bonneterre, Jacques, Fargeot, Pierre, Fumoleau, Pierre, Kerbrat, Pierre, Luporsi, Elisabeth, Namer, Moïse, Carrasco, Eva M, Segui, Miguel Angel, Meisner, Christoph, Loibl, Sibylle, Nekljudova, Valentina, Thomssen, Christoph, Von Minckwitz, Gunter, Kümmel, Sherko, Lopez, Massimo, Vici, Patrizia, Fountzilas, George, Koliou, Georgia, Mavroudis, Dimitrios, Saloustros, Emmanouil, Brain, Etienne, Delaloge, Suzette, Michiels, Stefan, Mathoulin-Pelissier, Simone, Bines, Jose, Sarmento, Roberta M B, Bonadonna, Gianni, Brambilla, Cristina, Rossi, Anna, Bliss, Judith, Coombes, Raoul Charles, Kilburn, Lucy, Marty, Michel, Amadori, Dino, Boccardo, Francesco, Nanni, Oriana, Rubagotti, Alessandra, Scarpi, Emanuela, Masuda, Norikazu, Toi, Masakazu, Ueno, Takayuki, Ishikawa, Takashi, Matsumoto, Koji, Takao, Shintaro, Sommer, Harald, Foroglou, Pericles, Giokas, George, Kondylis, D, Lissaios, Byron, Reinisch, Mattea, Lee, Keun Seok, Nam, Byung-Ho, Ro, Jung Sil, De Matteis, Andrea, Perrone, Francesco, Tang, Gong, Wolmark, Norman, Hozumi, Yasuo, Nomura, Yasuo, Earl, Helena, Hiller, Louise, Vallier, Anne-Laure, De Mastro, Lucia, Venturini, Macro, Delozier, Thierry, Lemonnier, Jerome, Martin, Anne-Laure, Roché, Henri, Spielmann, Marc, Chen, Xiasong, Shen, Kunwei, Albain, Kathy, Barlow, William, Budd, George T, Gralow, Julie, Hayes, Dan, Bartlett-Lee, Peter, Ellis, Paul, Bianco, Angelo Raffaele, De Laurentiis, Michelino, De Placido, Sabino, Wildiers, Hans, Hsu, Limin, Eremin, Oleg, Walker, Leslie G, Ahlgren, Johan, Blomqvist, Carl, Holmberg, Lars, Lindman, Henrik, Asmar, Lina, Jones, Stephen E, Gluz, Oleg, Liedtke, Cornelia, Arriagada, Rodrigo, Bergsten-Nordström, Elizabeth, Carey, Lisa, Coleman, Robert, Cuzick, Jack, Davidson, Nancy, Dignam, James, Dowsett, Mitch, Francis, Prudence A, Goetz, Matthew P, Goodwin, Pam, Halpin-Murphy, Pat, Hill, Catherine, Jagsi, Reshma, Mukai, Hirofumi, Ohashi, Yasuo, Pierce, Lori, Poortmans, Philip, Raina, Vinod, Rea, Daniel, Robertson, John, Rutgers, Emiel, Salgado, Roberto, Spanic, Tanja, Tutt, Andrew, Viale, Giuseppe, Wang, Xiang, Whelan, Tim, Wilcken, Nicholas, Cameron, David, Bergh, Jonas, and Swain, Sandra M
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- 2023
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22. Correlates of Blood Pressure Awareness, Treatment, and Control Among Adults 50 Years or Older by HIV Status in Northwestern Tanzania
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Muiruri, Charles, Wajanga, Bahati, Kim, Christine, Knettel, Brandon A., Mhina, Carl J., Bartlett, John A., Msangi, Jamal J., Msabah, Msabah A., Vilme, Helene, and Kalluvya, Samuel
- Published
- 2022
- Full Text
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23. Mesenchymal cell TRPM7 expression is required for bone formation via the regulation of chondrogenesis
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Shin, Masashi, Mori, Shihomi, Mizoguchi, Toshihide, Arai, Atsushi, Kajiya, Hiroshi, Okamoto, Fujio, Bartlett, John D., Matsushita, Masayuki, Udagawa, Nobuyuki, and Okabe, Koji
- Published
- 2023
- Full Text
- View/download PDF
24. Preparing Institutions to Implement Harmonized Medicine and Nursing Curricula Through the Use of Cross-Institutional Faculty Developers
- Author
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Mloka, Doreen, primary, Sakita, Francis, additional, Minja, Irene, additional, Dika, Haruna, additional, Tarimo, Edith, additional, Sirili, Nathanael, additional, Mselle, Lillian, additional, Kisenge, Rodrick, additional, Sasi, Philip, additional, Nsemwa, Livuka, additional, Msanga, Delfina, additional, Matayan, Einoti, additional, Ngowi, Nicholaus, additional, Moshi, Mainen, additional, Bartlett, John, additional, Macfarlane, Sarah, additional, Kaaya, Ephata, additional, and O'Sullivan, Patricia, additional
- Published
- 2024
- Full Text
- View/download PDF
25. Deregulation of the spindle assembly checkpoint is associated with paclitaxel resistance in ovarian cancer
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Chong, Taryne, Sarac, Amila, Yao, Cindy Q, Liao, Linda, Lyttle, Nicola, Boutros, Paul C, Bartlett, John MS, and Spears, Melanie
- Subjects
Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Orphan Drug ,Genetics ,Ovarian Cancer ,Cancer ,Rare Diseases ,Aetiology ,2.1 Biological and endogenous factors ,Antineoplastic Agents ,Phytogenic ,Apoptosis ,Biomarkers ,Cell Cycle Checkpoints ,Cell Line ,Tumor ,Cell Survival ,Drug Resistance ,Neoplasm ,Female ,Gene Expression Profiling ,Gene Regulatory Networks ,Humans ,Kaplan-Meier Estimate ,M Phase Cell Cycle Checkpoints ,Ovarian Neoplasms ,Paclitaxel ,Signal Transduction ,Spindle Apparatus ,Spindle assembly checkpoint ,Ovarian cancer ,Mitotic checkpoint serine/threonine kinase ,centromere protein E ,Centromere protein F ,Cyclin B1 ,Oncology and carcinogenesis ,Reproductive medicine - Abstract
BackgroundOvarian cancer is the leading gynecologic cancer diagnosed in North America and because related symptoms are not disease specific, this often leads to late detection, an advanced disease state, and the need for chemotherapy. Ovarian cancer is frequently sensitive to chemotherapy at diagnosis but rapid development of drug resistance leads to disease progression and ultimately death in the majority of patients.ResultsWe have generated paclitaxel resistant ovarian cell lines from their corresponding native cell lines to determine driver mechanisms of drug resistance using gene expression arrays. These paclitaxel resistant ovarian cells demonstrate: (1) Increased IC50 for paclitaxel and docetaxel (10 to 75-fold) and cross-resistance to anthracyclines (2) Reduced cell apoptosis in the presence of paclitaxel (3) Gene depletion involving mitotic regulators BUB1 mitotic checkpoint serine/threonine kinase, cyclin BI (CCNB1), centromere protein E (CENPE), and centromere protein F (CENPF), and (4) Functional data validating gene depletion among mitotic regulators.ConclusionsWe have generated model systems to explore drug resistance in ovarian cancer, which have revealed a key pathway related to the spindle assembly checkpoint underlying paclitaxel resistance in ovarian cell lines.
- Published
- 2018
26. Pathway-based subnetworks enable cross-disease biomarker discovery.
- Author
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Haider, Syed, Yao, Cindy Q, Sabine, Vicky S, Grzadkowski, Michal, Stimper, Vincent, Starmans, Maud HW, Wang, Jianxin, Nguyen, Francis, Moon, Nathalie C, Lin, Xihui, Drake, Camilla, Crozier, Cheryl A, Brookes, Cassandra L, van de Velde, Cornelis JH, Hasenburg, Annette, Kieback, Dirk G, Markopoulos, Christos J, Dirix, Luc Y, Seynaeve, Caroline, Rea, Daniel W, Kasprzyk, Arek, Lambin, Philippe, Lio', Pietro, Bartlett, John MS, and Boutros, Paul C
- Subjects
Humans ,Neoplasms ,Treatment Outcome ,Signal Transduction ,Cell Proliferation ,Algorithms ,Benchmarking ,Metabolic Networks and Pathways ,Biomarkers ,Tumor ,Biotechnology ,Genetics ,4.1 Discovery and preclinical testing of markers and technologies ,Biomarkers ,Tumor - Abstract
Biomarkers lie at the heart of precision medicine. Surprisingly, while rapid genomic profiling is becoming ubiquitous, the development of biomarkers usually involves the application of bespoke techniques that cannot be directly applied to other datasets. There is an urgent need for a systematic methodology to create biologically-interpretable molecular models that robustly predict key phenotypes. Here we present SIMMS (Subnetwork Integration for Multi-Modal Signatures): an algorithm that fragments pathways into functional modules and uses these to predict phenotypes. We apply SIMMS to multiple data types across five diseases, and in each it reproducibly identifies known and novel subtypes, and makes superior predictions to the best bespoke approaches. To demonstrate its ability on a new dataset, we profile 33 genes/nodes of the PI3K pathway in 1734 FFPE breast tumors and create a four-subnetwork prediction model. This model out-performs a clinically-validated molecular test in an independent cohort of 1742 patients. SIMMS is generic and enables systematic data integration for robust biomarker discovery.
- Published
- 2018
27. COVID-19: Rapid prototyping and production of face shields via flat, laser-cut, and 3D-printed models
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O'Connor, Sean, Mathew, Snehamol, Dave, Foram, Tormey, David, Parsons, Una, Gavin, Mel, Nama, Paul Mc, Moran, Ruth, Rooney, Mark, McMorrow, Ross, Bartlett, John, and Pillai, Suresh C.
- Published
- 2022
- Full Text
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28. Chile's Deadliest Wildfire Is Said to Have Been Made Worse by a Lack of Water
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McDonald, Brent, Soffia, Miguel, and Bartlett, John
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Wildfires ,General interest - Abstract
Byline: Brent McDonald, Miguel Soffia and John Bartlett Poor water pressure and dry hydrants posed major obstacles to fighting the February fire that killed scores of people along the country's [...]
- Published
- 2024
29. When Wildfire Swept Chile's Coast, the Hydrants Quickly Ran Dry
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McDonald, Brent, Soffia, Miguel, and Bartlett, John
- Subjects
Wildfires ,General interest ,News, opinion and commentary - Abstract
Poor water pressure and dry hydrants posed major obstacles to fighting the February fire that killed scores of people along the country's Pacific Coast. As a fast-moving wildfire swept through [...]
- Published
- 2024
30. La falta de agua agravó el incendio forestal más letal de Chile, según denuncias
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Mcdonald, Brent, Bartlett, John, and Soffia, Miguel
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News, opinion and commentary - Abstract
El incendio forestal que dejó 134 muertos y miles de casas destruidas fue impulsado por condiciones climáticas extremas. Según los bomberos y los residentes, la falta de agua en los [...]
- Published
- 2024
31. Tragedy, Resilience and a Miracle at Chile's Burned Botanical Garden
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Bartlett, John, Nicas, Jack, and Olivares, CristóBal
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Chile Wildfires, 2024 ,Wildfires ,General interest - Abstract
Byline: John Bartlett, Jack Nicas and Cristóbal Olivares Wildfires destroyed 98 percent of Chile's national botanical garden and killed a worker and her family. But there were signs of hope [...]
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- 2024
32. 'We're Broken': Wildfires on Chile's Coast Kill 112 and Leave Hundreds Missing
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Correal, Annie and Bartlett, John
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Wildfires ,General interest - Abstract
Byline: Annie Correal and John Bartlett Officials are warning of major destruction and loss of life after fast-moving fires swept through central Chile's coastal hills. Days after devastating wildfires ripped [...]
- Published
- 2024
33. Seeking Hope in the Ashes After Fires Wreck Chile's Botanical Garden
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Bartlett, John, Nicas, Jack, and Olivares, CristóBal
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Chile Wildfires, 2024 ,Botanical gardens -- Destruction ,Natural disaster damage -- Evaluation ,Wildfires -- Environmental aspects ,General interest ,News, opinion and commentary - Abstract
Wildfires destroyed 98 percent of Chile's national botanical garden and killed a worker and her family. But there were signs of hope in the ashes. On Friday afternoon, several hundred [...]
- Published
- 2024
34. Los incendios forestales en Chile consumieron un jardín botánico de 107 años
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Bartlett, John, Nicas, Jack, and Olivares, Cristóbal
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News, opinion and commentary - Abstract
El Jardín Botánico Nacional, ubicado en Viña del Mar, llora la pérdida de una trabajadora y su familia. Y espera un milagro para sus plantas. El viernes por la tarde, [...]
- Published
- 2024
35. Coastal Wildfires in Chile Kill Dozens and Leave Hundreds of Others Missing
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Correal, Annie and Bartlett, John
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Chile -- Environmental aspects ,Chile Wildfires, 2024 ,Disaster victims ,Evacuation of civilians ,Natural disaster damage ,General interest ,News, opinion and commentary - Abstract
Officials are warning of major destruction and loss of life after fast-moving fires swept through central Chile's coastal hills. Days after devastating wildfires ripped through Chile's Pacific Coast, ravaging entire [...]
- Published
- 2024
36. ‘Estamos destrozados’: incendios forestales en la costa de Chile causan 112 muertes y centenares de desapariciones
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Correal, Annie, Bartlett, John, and Olivares, Cristóbal
- Subjects
News, opinion and commentary - Abstract
Las autoridades anticipan una gran destrucción y pérdidas de vidas humanas tras los incendios que arrasan las colinas costeras del centro de Chile. Días después de que devastadores incendios arrasaron [...]
- Published
- 2024
37. Wildfires Threatening 2 Chilean Cities Destroy 1,000 Homes and Kill at Least 46
- Author
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Bartlett, John
- Subjects
Chile Wildfires, 2024 ,Natural disaster damage -- Influence -- Casualties ,Wildfires -- Casualties -- Influence ,General interest ,News, opinion and commentary - Abstract
The death toll is expected to rise as hundreds have been reported missing in the blazes near the cities of Viña del Mar and Valparaíso, an area home to more [...]
- Published
- 2024
38. Wildfires Threaten 2 Chilean Cities, Destroying 1,000 Homes and Killing 46
- Author
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Bartlett, John
- Subjects
Natural disaster damage ,Wildfires ,Missing persons ,News, opinion and commentary - Abstract
The death toll is expected to rise as hundreds have been reported missing in the blazes threatening the cities of Viña del Mar and Valparaíso, a region home to more [...]
- Published
- 2024
39. Correlative studies of the Breast Cancer Index (HOXB13/IL17BR) and ER, PR, AR, AR/ER ratio and Ki67 for prediction of extended endocrine therapy benefit: a Trans-aTTom study
- Author
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Sgroi, Dennis C., Treuner, Kai, Zhang, Yi, Piper, Tammy, Salunga, Ranelle, Ahmed, Ikhlaaq, Doos, Lucy, Thornber, Sarah, Taylor, Karen J., Brachtel, Elena, Pirrie, Sarah, Schnabel, Catherine A., Rea, Daniel, and Bartlett, John M. S.
- Published
- 2022
- Full Text
- View/download PDF
40. Upregulation of IFNɣ-mediated chemokines dominate the immune transcriptome of muscle-invasive urothelial carcinoma
- Author
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Olkhov-Mitsel, Ekaterina, Hodgson, Anjelica, Liu, Stan K., Vesprini, Danny, Bayani, Jane, Bartlett, John M. S., Xu, Bin, and Downes, Michelle R.
- Published
- 2022
- Full Text
- View/download PDF
41. Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials
- Author
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Bradley, Rosie, Braybrooke, Jeremy, Gray, Richard, Hills, Robert K, Liu, Zulian, Pan, Hongchao, Peto, Richard, Dodwell, David, McGale, Paul, Taylor, Carolyn, Francis, Prudence A, Gnant, Michael, Perrone, Francesco, Regan, Meredith M, Berry, Richard, Boddington, Clare, Clarke, Mike, Davies, Christina, Davies, Lucy, Duane, Fran, Evans, Vaughan, Gay, Jo, Gettins, Lucy, Godwin, Jon, James, Sam, Liu, Hui, MacKinnon, Elizabeth, Mannu, Gurdeep, McHugh, Theresa, Morris, Philip, Read, Simon, Straiton, Ewan, Jakesz, Raimund, Fesl, Christian, Pagani, Olivia, Gelber, Richard, De Laurentiis, Michelino, De Placido, Sabino, Gallo, Ciro, Albain, Kathy, Anderson, Stewart, Arriagada, Rodrigo, Bartlett, John, Bergsten-Nordström, Elizabeth, Bliss, Judith, Brain, Etienne, Carey, Lisa, Coleman, Robert, Cuzick, Jack, Davidson, Nancy, Del Mastro, Lucia, Di Leo, Angelo, Dignam, James, Dowsett, Mitch, Ejlertsen, Bent, Goetz, Matthew, Goodwin, Pam, Halpin-Murphy, Pat, Hayes, Dan, Hill, Catherine, Jagsi, Reshma, Janni, Wolfgang, Loibl, Sibylle, Mamounas, Eleftherios P, Martín, Miguel, Mukai, Hirofumi, Nekljudova, Valentina, Norton, Larry, Ohashi, Yasuo, Pierce, Lori, Poortmans, Philip, Pritchard, Kathleen I, Raina, Vinod, Rea, Daniel, Robertson, John, Rutgers, Emiel, Spanic, Tanja, Sparano, Joseph, Steger, Guenther, Tang, Gong, Toi, Masakazu, Tutt, Andrew, Viale, Giuseppe, Wang, Xiang, Whelan, Tim, Wilcken, Nicholas, Wolmark, Norman, Cameron, David, Bergh, Jonas, and Swain, Sandra M
- Published
- 2022
- Full Text
- View/download PDF
42. Influence of peer discussions on trust in recommendations for prevention of mother-to-child transmission (PMTCT) of HIV.
- Author
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Philemon, Rune Nathaniel, Mboya, Innocent B., Mmbaga, Blandina T., Bartlett, John, and Msuya, Sia E.
- Subjects
VERTICAL transmission (Communicable diseases) ,PEER pressure ,PEER relations ,MEDICAL personnel ,MOTHERS - Abstract
Background: Mothers attending prevention of mother-to-child transmission (PMTCT) of HIV clinics seem to lack knowledge on many aspects of PMTCT, among which is breastfeeding. Breastfeeding recommendations in PMTCT have changed several times over the years leaving some confused and doubtful of what is currently recommended. One method shown to help improve their knowledge and acceptance of PMTCT recommendations is the use of peer educators. We sought to determine if mothers engage in discussions with other mothers during clinics and how these engagements influence trust in PMTCT recommendations. Methods: We interviewed 524 mothers with children under two years enrolled in PMTCT clinics in Kilimanjaro, Tanzania. We selected 5 clinics with the highest numbers of PMTCT enrolment from each district in the region. In each clinic, over a one-month period, we recruited all mothers attending the PMTCT clinic. We collected information on their engagement in discussions regarding PMTCT during clinics and how they perceived the information from their peers in relation to that from healthcare providers. Results: Fifty-five percent of the mothers reported engaging in peer discussions. Of the 90 (17%) mothers who reported noticing a change in PMTCT recommendations, 33 (36.7%) reported trusting previous recommendations more. A greater proportion (52.9%) of mothers who engaged in peer discussions reported trusting the information from peers more than that from healthcare workers. Conclusions: Peers have a great influence on mothers, which is concerning when their knowledge shared is outdated. Harnessing their influence and training them on current recommendations might be key to improving adherence to PMTCT recommendations. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
43. Fluoride Alters Gene Expression via Histone H3K27 Acetylation in Ameloblast-like LS8 Cells.
- Author
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Yamashita, Shohei, Okamoto, Motoki, Mendonca, Melanie, Fujiwara, Natsumi, Kitamura, Eiko, Chang, Chang-Sheng Sam, Brueckner, Susanne, Shindo, Satoru, Kuriki, Nanako, Cooley, Marion A., Gill Dhillon, Navi, Kawai, Toshihisa, Bartlett, John D., Everett, Eric T., and Suzuki, Maiko
- Subjects
HISTONE acetyltransferase ,GENE expression ,FLUOROSIS ,HISTONE acetylation ,SODIUM butyrate - Abstract
Excessive fluoride ingestion during tooth development can cause dental fluorosis. Previously, we reported that fluoride activates histone acetyltransferase (HAT) to acetylate p53, promoting fluoride toxicity in mouse ameloblast-like LS8 cells. However, the roles of HAT and histone acetylation status in fluoride-mediated gene expression remain unidentified. Here, we demonstrate that fluoride-mediated histone modification causes gene expression alterations in LS8 cells. LS8 cells were treated with or without fluoride followed by ChIP-Seq analysis of H3K27ac. Genes were identified by differential H3K27ac peaks within ±1 kb from transcription start sites. The levels of mRNA of identified genes were assessed using rea-time PCR (qPCR). Fluoride increased H3K27ac peaks associated with Bax, p21, and Mdm2 genes and upregulated their mRNA levels. Fluoride decreased H3K27ac peaks and p53, Bad, and Bcl2 had suppressed transcription. HAT inhibitors (Anacardic acid or MG149) suppressed fluoride-induced mRNA of p21 and Mdm2, while fluoride and the histone deacetylase (HDAC) inhibitor sodium butyrate increased Bad and Bcl2 expression above that of fluoride treatment alone. To our knowledge, this is the first study that demonstrates epigenetic regulation via fluoride treatment via H3 acetylation. Further investigation is required to elucidate epigenetic mechanisms of fluoride toxicity in enamel development. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
44. Adjunctive Statistical Standardization of Adjuvant Estrogen Receptor and Progesterone Receptor in Canadian Cancer Trials Group MA.27 Postmenopausal Breast Cancer Trial of Exemestane Versus Anastrozole.
- Author
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Chapman, Judith-Anne W., Bayani, Jane, SenGupta, Sandip, Bartlett, John M.S., Piper, Tammy, Quintayo, Mary Anne, Virk, Shakeel, Goss, Paul E., Ingle, James N., Ellis, Matthew J., Sledge, George W., Budd, G. Thomas, Rabaglio, Manuela, Ansari, Rafat H., Tozer, Richard, D'Souza, David P., Chalchal, Haji, Spadafora, Silvana, Stearns, Vered, and Perez, Edith A.
- Published
- 2024
- Full Text
- View/download PDF
45. Proteinases in Enamel Development
- Author
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Shahid, Shifa, Bartlett, John D., Karamanos, Nikos K., Series Editor, Kletsas, Dimitris, Editorial Board Member, Oh, Eok-Soo, Editorial Board Member, Passi, Alberto, Editorial Board Member, Pihlajaniemi, Taina, Editorial Board Member, Ricard-Blum, Sylvie, Editorial Board Member, Sagi, Irit, Editorial Board Member, Savani, Rashmin, Editorial Board Member, Watanabe, Hideto, Editorial Board Member, Goldberg, Michel, editor, and Den Besten, Pamela, editor
- Published
- 2021
- Full Text
- View/download PDF
46. Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients
- Author
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Adamson, Kathi, Albain, Kathy S., Asare, Adam L., Asare, Smita M., Balassanian, Ron, Beckwith, Heather, Berry, Scott M., Berry, Donald A., Boughey, Judy C., Buxton, Meredith B., Chen, Yunn-Yi, Chen, Beiyun, Chien, A. Jo, Chui, Stephen Y., Clark, Amy S., Clennell, Julia L., Datnow, Brian, DeMichele, Angela M., Duan, Xiuzhen, Edmiston, Kirsten K., Elias, Anthony D., Ellis, Erin D., Esserman, Laura L., Euhus, David M., Fadare, Oluwole, Fan, Fang, Feldman, Michael D, Forero-Torres, Andres, Haley, Barbara B., Han, Hyo S., Harada, Shuko, Haugen, Patricia, Helsten, Teresa, Hirst, Gillian L., Hylton, Nola M., Isaacs, Claudine, Kemmer, Kathleen, Khan, Qamar J., Khazai, Laila, Klein, Molly E., Krings, Gregor, Lang, Julie E., LeBeau, Lauren G., Leyland-Jones, Brian, Liu, Minetta C., Lo, Shelly, Lu, Janice, Magliocco, Anthony, Matthews, Jeffrey B., Melisko, Michelle E., Mhawech-Fauceglia, Paulette, Moulder, Stacy L., Murthy, Rashmi K., Nanda, Rita, Northfelt, Donald W., Ocal, Idris T., Olopade, Olufunmilayo, Pambuccian, Stefan, Paoloni, Melissa, Park, John W., Parker, Barbara A., Perlmutter, Jane, Peterson, Garry, Pusztai, Lajos, Rendi, Mara, Rugo, Hope S., Sahoo, Sunati, Sams, Sharon, Sanil, Ashish, Sattar, Husain, Schwab, Richard B., Singhrao, Ruby, Steeg, Katherine, Stringer-Reasor, Erica, Symmans, W. Fraser, Tawfik, Ossama, Tripathy, Debasish, Troxell, Megan L., van't Veer, Laura J., Venters, Sara J., Vinh, Tuyethoa, Viscusi, Rebecca K., Wallace, Anne M., Wei, Shi, Wilson, Amy, Yau, Christina, Yee, Douglas, Zeck, Jay C., Osdoit, Marie, van der Noordaa, Marieke, Shad, Sonal, Wei, Jane, de Croze, Diane, Hamy, Anne-Sophie, Laé, Marick, Reyal, Fabien, Sonke, Gabe S, Steenbruggen, Tessa G, van Seijen, Maartje, Wesseling, Jelle, Martín, Miguel, del Monte-Millán, Maria, López-Tarruella, Sara, Boughey, Judy C, Goetz, Matthew P, Hoskin, Tanya, Gould, Rebekah, Valero, Vicente, Edge, Stephen B, Abraham, Jean E, Bartlett, John M S, Caldas, Carlos, Dunn, Janet, Earl, Helena, Hayward, Larry, Hiller, Louise, Provenzano, Elena, Sammut, Stephen-John, Thomas, Jeremy S, Cameron, David, Graham, Ashley, Hall, Peter, Mackintosh, Lorna, Godwin, Andrew K, Schwensen, Kelsey, Sharma, Priyanka, DeMichele, Angela M, Cole, Kimberly, Kim, Mi-Ok, van 't Veer, Laura J, Esserman, Laura J, and Symmans, W Fraser
- Published
- 2022
- Full Text
- View/download PDF
47. JSST Editorial
- Author
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Bartlett, John
- Published
- 2023
- Full Text
- View/download PDF
48. Multi-omic machine learning predictor of breast cancer therapy response
- Author
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Sammut, Stephen-John, Crispin-Ortuzar, Mireia, Chin, Suet-Feung, Provenzano, Elena, Bardwell, Helen A., Ma, Wenxin, Cope, Wei, Dariush, Ali, Dawson, Sarah-Jane, Abraham, Jean E., Dunn, Janet, Hiller, Louise, Thomas, Jeremy, Cameron, David A., Bartlett, John M. S., Hayward, Larry, Pharoah, Paul D., Markowetz, Florian, Rueda, Oscar M., Earl, Helena M., and Caldas, Carlos
- Published
- 2022
- Full Text
- View/download PDF
49. Incorporation of TILs in daily breast cancer care: how much evidence can we bear?
- Author
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Laenkholm, Anne-Vibeke, Callagy, Grace, Balancin, Marcelo, Bartlett, John M. S., Sotiriou, Christos, Marchio, Caterina, Kok, Marleen, Dos Anjos, Carlos Henrique, and Salgado, Roberto
- Published
- 2022
- Full Text
- View/download PDF
50. Effect of over-the-counter brimonidine tartrate 0.025% ophthalmic solution on pupil size in healthy adults
- Author
-
Nejad, Mitra, Lin, Shawn R., Hwang, Linda H., Landig, Mark, Al-Hashimi, Saba, and Bartlett, John D.
- Published
- 2021
- Full Text
- View/download PDF
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