18 results on '"Berendsen, Steven"'
Search Results
2. Staging and profiling for schizophrenia spectrum disorders: Inter-rater reliability after a short training course
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Berendsen, Steven, van der Paardt, Jasper W., Van, Henricus L., van Bruggen, Marion, Nusselder, Hans, Jalink, Margje, de Peuter, Olav R., Peen, Jaap, van Tricht, Mirjam J., and de Haan, Lieuwe
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- 2020
- Full Text
- View/download PDF
3. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study
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Quattrone, Diego, Reininghaus, Ulrich, Richards, Alex L., Tripoli, Giada, Ferraro, Laura, Quattrone, Andrea, Marino, Paolo, Rodriguez, Victoria, Spinazzola, Edoardo, Gayer-Anderson, Charlotte, Jongsma, Hannah E., Jones, Peter B., La Cascia, Caterina, La Barbera, Daniele, Tarricone, Ilaria, Bonora, Elena, Tosato, Sarah, Lasalvia, Antonio, Szöke, Andrei, Arango, Celso, Bernardo, Miquel, Bobes, Julio, Del Ben, Cristina Marta, Menezes, Paulo Rossi, Llorca, Pierre-Michel, Santos, Jose Luis, Sanjuán, Julio, Arrojo, Manuel, Tortelli, Andrea, Velthorst, Eva, Berendsen, Steven, De Haan, Lieuwe, Rutten, Bart P. F., Lynskey, Michael T., Freeman, Tom P., Kirkbride, James B., Sham, Pak C., O’Donovan, Michael C., Cardno, Alastair G., Vassos, Evangelos, Van Os, Jim, Morgan, Craig, Murray, Robin M., Lewis, Cathryn M., Di Forti, Marta, Hubbard, Kathryn, Beards, Stephanie, Stilo, Simona A., Parellada, Mara, Fraguas, David, Castro, Marta Rapado, Andreu-Bernabeu, Álvaro, López, Gonzalo, Matteis, Mario, González, Emiliano, Durán-Cutilla, Manuel, Díaz-Caneja, Covadonga M., Cuadrado, Pedro, Rodríguez Solano, José Juan, Carracedo, Angel, Costas, Javier, Sánchez, Emilio, Amoretti, Silvia, Lorente-Rovira, Esther, Garcia-Portilla, Paz, Jiménez-López, Estela, Franke, Nathalie, Van Dam, Daniella, Termorshuizen, Fabian, Van Der Ven, Elsje, Messchaart, Elles, Leboyer, Marion, Schürhoff, Franck, Jamain, Stéphane, Baudin, Grégoire, Ferchiou, Aziz, Pignon, Baptiste, Richard, Jean-Romain, Charpeaud, Thomas, Tronche, Anne-Marie, Frijda, Flora, Marrazzo, Giovanna, Sideli, Lucia, Sartorio, Crocettarachele, Seminerio, Fabio, Loureiro, Camila Marcelino, Shuhama, Rosana, Ruggeri, Mirella, Bonetto, Chiara, Cristofalo, Doriana, Berardi, Domenico, Seri, Marco, D’Andrea, Giuseppe, Quattrone, Diego [0000-0002-6051-8309], Richards, Alex L. [0000-0003-3218-7247], Marino, Paolo [0000-0003-3571-1753], Rodriguez, Victoria [0000-0003-0383-0846], Jones, Peter B. [0000-0002-0387-880X], Tosato, Sarah [0000-0002-9665-7538], Bernardo, Miquel [0000-0001-8748-6717], Bobes, Julio [0000-0003-2187-4033], Del Ben, Cristina Marta [0000-0003-0145-9975], Menezes, Paulo Rossi [0000-0001-6330-3314], Llorca, Pierre-Michel [0000-0001-7438-8990], Rutten, Bart P. F. [0000-0002-9834-6346], Kirkbride, James B. [0000-0003-3401-0824], O’Donovan, Michael C. [0000-0001-7073-2379], Vassos, Evangelos [0000-0001-6363-0438], Murray, Robin M. [0000-0003-0829-0519], Lewis, Cathryn M. [0000-0002-8249-8476], and Apollo - University of Cambridge Repository
- Subjects
45 ,692/699/476/1799 ,692/53/2423 ,45/43 ,article ,631/208/2489 - Abstract
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03–0.33) and positive (B = 0.19; 95%CI 0.03–0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11–0.52) and in controls (B = 0.26; 95%CI 0.06–0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders.
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- 2021
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4. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Calem, Maria, Tognin, Stefania, Modinos, Gemma, Pisani, Sara, Kraan, Tamar C., van Dam, Daniella S., Burger, Nadine, McGorry, Patrick, Amminger, G. Paul, Politis, Athena, Goodall, Joanne, Borgwardt, Stefan, Studerus, Erich, Gadelha, Ary, Brietzke, Elisa, Asevedo, Graccielle, Asevedo, Elson, Zugman, Andre, Domínguez-Martínez, Tecelli, Monsonet, Manel, Hinojosa, Lidia, Cristóbal-Narváez, Paula, Racioppi, Anna, Kwapil, Thomas R., Kazes, Mathilde, Daban, Claire, Bourgin, Julie, Gay, Olivier, Mam-Lam-Fook, Célia, Nordholm, Dorte, Randers, Lasse, Krakauer, Kristine, Glenthøj, Louise Birkedal, Glenthøj, Birte, Gebhard, Dominika, Arnhold, Julia, Klosterkötter, Joachim, Lasser, Iris, Winklbaur, Bernadette, Delespaul, Philippe A., Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuán, Julio, Santos, José Luis, Szöke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rössler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P.F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
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- 2021
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5. The backwoods of clinical and research assessment of psychosis
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Berendsen, Steven, de Haan, L., van Tricht, M.J., Van, H.L., Faculteit der Geneeskunde, de Haan, Lieuwe, van Tricht, Mirjam J., Van, H. L., Adult Psychiatry, and Graduate School
- Abstract
The aim of this thesis was to explore and improve methodology and utility of clinically applicable dimensional, staging and clinical profiling models for patients with psychotic and related disorders. This was approached at three levels: firstly, we evaluated the psychometric properties of the dimensional assessment of symptoms by the Clinician-Rated Dimensions of Psychosis Symptom Severity, and subsequently, determining the inter-rater reliability of the clinical staging model and profile characteristics. We evaluated inter-rater reliability with and without short training courses suitable for clinical practice (Part 1). Secondly, we evaluated the validity of the clinical staging model in schizophrenia spectrum disorders. We determined the construct and clinical validity of the staging model in ambulatory and clinically admitted patients. Furthermore, we assessed whether cognitive parameters are associated with higher clinical stages in a large sample of patients with psychotic disorders (Part 2). Thirdly, we evaluated the pre-training inter-rater reliability in clinical research. Moreover, we determined the proportion of reported inter-rater reliability coefficients and training procedures in double-blind randomized clinical trials with antipsychotic and antidepressant medication. Overall, we conclude that achieving sufficient inter-rater reliability of new diagnostic methods requires more attention, both in scientific research and in daily practice. This field of research can also be marked as the backwoods of clinical and research assessments — remote areas that could be neglected because of difficulties that may be encountered.
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- 2021
6. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, de Haan, Lieuwe, Berendsen, Steven, Kapitein, Pim, Schirmbeck, Frederike, van Tricht, Mirjam J., McGuire, Philip, Morgan, Craig, Gayer-Anderson, Charlotte, Kempton, Matthew J., Valmaggia, Lucia, Quattrone, Diego, di Forti, Marta, van der Gaag, Mark, Kirkbride, James B., Jongsma, Hannah E., Jones, Peter B., Parellada, Maria, Arango, Celso, Arrojo, Manuel, Bernardo, Miguel, Sanjuan, Julio, Santos, Jose Luis, Szoke, Andrei, Tortelli, Andrea, Llorca, Pierre-Michel, Tarricone, Ilaria, Tripoli, Giada, Ferraro, Laura, La Cascia, Caterina, Lasalvia, Antonio, Tosato, Sarah, Menezes, Paulo Rossi, Del-Ben, Cristina Marta, Nelson, Barnaby, Riecher-Rossler, Anita, Bressan, Rodrigo, Barrantes-Vidal, Neus, Krebs, Marie-Odile, Nordentoft, Merete, Ruhrmann, Stephan, Sachs, Gabriele, Rutten, Bart P. F., van Os, Jim, Velthorst, Eva, and de Haan, Lieuwe
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- 2021
7. An old but still burning problem: Inter-rater reliability in clinical trials with antidepressant medication
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Berendsen, Steven, Verdegaal, Loek M. A, van Tricht, Mirjam J., Blankers, Matthijs, Van, Henricus L., and de Haan, Lieuwe
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- 2020
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8. Pre-training inter-rater reliability of clinical instruments in an international psychosis research project
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Berendsen, Steven, primary, Kapitein, Pim, additional, Schirmbeck, Frederike, additional, van Tricht, Mirjam J., additional, McGuire, Philip, additional, Morgan, Craig, additional, Gayer-Anderson, Charlotte, additional, Kempton, Matthew J., additional, Valmaggia, Lucia, additional, Quattrone, Diego, additional, di Forti, Marta, additional, van der Gaag, Mark, additional, Kirkbride, James B., additional, Jongsma, Hannah E., additional, Jones, Peter B., additional, Parellada, Maria, additional, Arango, Celso, additional, Arrojo, Manuel, additional, Bernardo, Miguel, additional, Sanjuán, Julio, additional, Santos, José Luis, additional, Szöke, Andrei, additional, Tortelli, Andrea, additional, Llorca, Pierre-Michel, additional, Tarricone, Ilaria, additional, Tripoli, Giada, additional, Ferraro, Laura, additional, La Cascia, Caterina, additional, Lasalvia, Antonio, additional, Tosato, Sarah, additional, Menezes, Paulo Rossi, additional, Del-Ben, Cristina Marta, additional, Nelson, Barnaby, additional, Riecher-Rössler, Anita, additional, Bressan, Rodrigo, additional, Barrantes-Vidal, Neus, additional, Krebs, Marie-Odile, additional, Nordentoft, Merete, additional, Ruhrmann, Stephan, additional, Sachs, Gabriele, additional, Rutten, Bart P.F., additional, van Os, Jim, additional, Velthorst, Eva, additional, de Haan, Lieuwe, additional, Calem, Maria, additional, Tognin, Stefania, additional, Modinos, Gemma, additional, Pisani, Sara, additional, Kraan, Tamar C., additional, van Dam, Daniella S., additional, Burger, Nadine, additional, McGorry, Patrick, additional, Amminger, G. Paul, additional, Politis, Athena, additional, Goodall, Joanne, additional, Borgwardt, Stefan, additional, Studerus, Erich, additional, Gadelha, Ary, additional, Brietzke, Elisa, additional, Asevedo, Graccielle, additional, Asevedo, Elson, additional, Zugman, Andre, additional, Domínguez-Martínez, Tecelli, additional, Monsonet, Manel, additional, Hinojosa, Lidia, additional, Cristóbal-Narváez, Paula, additional, Racioppi, Anna, additional, Kwapil, Thomas R., additional, Kazes, Mathilde, additional, Daban, Claire, additional, Bourgin, Julie, additional, Gay, Olivier, additional, Mam-Lam-Fook, Célia, additional, Nordholm, Dorte, additional, Randers, Lasse, additional, Krakauer, Kristine, additional, Glenthøj, Louise Birkedal, additional, Glenthøj, Birte, additional, Gebhard, Dominika, additional, Arnhold, Julia, additional, Klosterkötter, Joachim, additional, Lasser, Iris, additional, Winklbaur, Bernadette, additional, and Delespaul, Philippe A., additional
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- 2021
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9. The bumpy road to achieve reliability of clinical profile characteristics in psychosis and related disorders
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Berendsen, Steven, primary, van Tricht, Mirjam J., additional, Tedja, Amy, additional, Burger, Thijs J., additional, de Koning, Mariken B., additional, and de Haan, Lieuwe, additional
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- 2020
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10. Exploration of symptom dimensions and duration of untreated psychosis within a staging model of schizophrenia spectrum disorders
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Berendsen, Steven, primary, Van, Henricus L., additional, Paardt, Jasper W., additional, Peuter, Olav R., additional, Bruggen, Marion, additional, Nusselder, Hans, additional, Jalink, Margje, additional, Peen, Jaap, additional, Dekker, Jack J. M., additional, and Haan, Lieuwe, additional
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- 2020
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11. Burying Our Heads in the Sand: The Neglected Importance of Reporting Inter-Rater Reliability in Antipsychotic Medication Trials
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Berendsen, Steven, primary, Van, Henricus L, additional, Verdegaal, Loek M A, additional, van Tricht, Mirjam J, additional, Blankers, Matthijs, additional, and de Haan, Lieuwe, additional
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- 2020
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12. Exploration of symptom dimensions and duration of untreated psychosis within a staging model of schizophrenia spectrum disorders.
- Author
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Berendsen, Steven, Van, Henricus L., Paardt, Jasper W., Peuter, Olav R., Bruggen, Marion, Nusselder, Hans, Jalink, Margje, Peen, Jaap, Dekker, Jack J. M., and Haan, Lieuwe
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SCHIZOPHRENIA , *PSYCHOSES , *SYMPTOMS , *DISEASE remission , *22Q11 deletion syndrome - Abstract
Aim: Clinical staging of schizophrenia entails a new method that identifies clusters of symptoms and variation in level of remission, with the goal to create a framework for early intervention. Additionally, duration of untreated psychosis (DUP) may influence symptom severity in the first episode of psychosis (FEP) and could necessitate refining of the staging model. However, consistent evidence concerning variation in symptom severity and DUP between stages is missing. Therefore, we evaluated the clinical validity of the staging model by investigating differences in symptom severity across stages in schizophrenia spectrum disorders. Second, we assessed if a prolonged DUP is associated with higher symptom severity in FEP. Methods: We performed a cross‐sectional study of 291 acutely admitted patients with a schizophrenia spectrum disorder. Patients were assigned to clinical stages following the definition of McGorry. Symptom severity was evaluated with the new DSM‐5 Clinician‐Rated Dimensions of Psychosis Symptom Severity (CRDPSS). In FEP, we determined the DUP. Results: Significantly higher severity scores of CRDPSS items hallucinations (H = 14.34, df = 4, P‐value =.006), negative symptoms (H = 19.678, df = 4, P‐value =.001) and impaired cognition (H = 26.294, df = 4, P‐value = <.001) were found in more advanced stages of disease. Moreover, patients with FEP and a DUP longer than 1 year showed significantly more severe negative symptoms (U = 314 000, P =.015) compared to patients with a DUP shorter than 1 year. Conclusions: The present study found supporting evidence for the clinical validity of the staging model in schizophrenia spectrum disorders. In addition, we found support for refining the stage "first episode" with information concerning the DUP. [ABSTRACT FROM AUTHOR]
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- 2021
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13. The bumpy road to achieve reliability of clinical profile characteristics in psychosis and related disorders.
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Berendsen, Steven, van Tricht, Mirjam J., Tedja, Amy, Burger, Thijs J., de Koning, Mariken B., and de Haan, Lieuwe
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SUBSTANCE abuse , *INTRACLASS correlation , *PSYCHOSES , *DIAGNOSIS , *PROGNOSIS - Abstract
Objectives: Profile characteristics are factors that are relevant for diagnosis, prognosis or treatment. The present study aims to develop a set of clinically relevant profile characteristics. Moreover, our goal is to determine the inter‐rater reliability (IRR) of the selected profile characteristics. Methods: Potential profile characteristics were determined by literature review. Assessment of IRR was done by comparing scores on profile characteristics determined by two researchers. We conducted three subsequent studies: (1) assessment of pre‐training IRR, (2) IRR following implementation of an instruction manual, (3) IRR after optimizing scoring methods. IRR was measured with the Intraclass Correlation Coefficient (ICC). Results: IRR scores of profile characteristic Illegal activities were high across the three studies (ICC ≥ 0.75). Following training procedures in study 2 and 3, reliability estimates remained low to moderate (ICC < 0.75) for the profile characteristics Support of relatives, Aggression recent and lifetime, substance use and insight recent. IRR scores of the other eight profile characteristics varied from low, moderate to high across studies. Conclusion: IRR scores of profile characteristics were highly variable, and mostly inadequate in all three studies. Consequently, further research should focus on specification of severity scores of profile characteristics, optimizing scoring methods and re‐evaluation of IRR. [ABSTRACT FROM AUTHOR]
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- 2021
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14. Exploring construct validity of clinical staging in schizophrenia spectrum disorders in an acute psychiatric ward
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Berendsen, Steven, primary, van der Paardt, Jasper, additional, van Bruggen, Marion, additional, Nusselder, Hans, additional, Jalink, Margje, additional, Peen, Jaap, additional, Van, Henricus, additional, Dekker, Jack, additional, and de Haan, Lieuwe, additional
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- 2018
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15. THREE-DIMENSIONAL RECONSTRUCTION OF THE ANTERIOR OLFACTORY NUCLEUS IN THE HUMAN OLFACTORY BULB AND PEDUNCLE. Reconstrucción tridimiensional del núcleo olfatorio anterior en el bulbo y pedúnculo olfatorio humano
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Berendsen, Steven, primary, Peters, Jocelyne V M, additional, Huisman, Evelien, additional, Vörster, Willie, additional, and Hoogland, Piet, additional
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- 2016
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16. THREE-DIMENSIONAL RECONSTRUCTION OF THE ANTERIOR OLFACTORY NUCLEUS IN THE HUMAN OLFACTORY BULB AND PEDUNCLE.
- Author
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Berendsen, Steven, Peters, Jocelyne V. M., Huisman, Evelien, Vorster, Willie, and Hoogland, Piet
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NERVE cell culture , *MORPHOLOGY - Abstract
The human olfactory bulb and peduncle contain several more or less separated cell groups that are usually regarded to be part of the retrobulbar anterior olfactory nucleus (AON). The assumption that these cell groups are to be considered as the rostral extension of the AON in the rostral hemisphere goes back to the description of one single case by Crosby and Humphrey (1941). To improve our understanding of the anatomy of the human bulbar and peduncular AON, we investigated the morphology, size and shape of these parts of this nucleus in postmortem tissue of aged individuals. Six olfactory bulbs and peduncles including the substantia perforata anterior (SPA) were obtained from donor brains and 40μm horizontal serial sections were cut and stained with Nissl substance. The medium to large sized neurons of these parts of the AON were intensely stained and had an average diameter of 16μm. Three dimensional reconstruction demonstrated that in all but one of the cases the bulbar and peduncular AON consisted on a discontinuous chain of cell groups connected by cell poor to cell free bridges of neuropile. The number of cell groups and the connecting bridges differ in every individual. We arrived at the conclusion that the bulbar and peduncular parts of the human AON should be regarded a human specialization rather than just being rostral extensions of the retrobulbar AON area. This is in line with previously published neurochemical properties and the selective early, preclinical degener-ation of these cell clusters in neurodegenerative diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2015
17. Making Sense of Recovery From First Psychosis With Antipsychotic Medication: A Qualitative Phenomenological Study.
- Author
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Dijkstra SA, Rijkeboer J, Noordhof A, Boyette LL, Berendsen S, de Koning M, Bennen RLJ, Hofman T, and de Haan L
- Abstract
Background and Hypothesis: Recovering from a first psychosis is a highly individual process and requires the person to make sense of their experiences. Clinicians, in turn, need to comprehend these first-person perspectives, creating a mutual sense-making dynamic. Antipsychotic medication is a substantial part of psychosis treatment. Providing insight in the lived experience of recovery with antipsychotics could improve the mutual understanding and help bridge the gap between the perspective of the clinician and that of the person recovering from psychosis., Study Design: 14 persons in recovery from a first psychosis with the use of antipsychotics were interviewed. Their narratives were analyzed using Interpretative Phenomenological Analysis (IPA)., Study Results: Five overarching themes were found, representing important and meaningful experiences in recovering with antipsychotic medication. Theme 1: antipsychotics as external dampening (4 subthemes); Theme 2: shifting of realities; Theme 3: pace of recovery; Theme 4: antipsychotics' influence on identity; and Theme 5: is it truly the antipsychotics?, Conclusions: Our findings show that recovery from psychosis with antipsychotics is an all-encompassing, multi-faceted, and ambivalent experience. The themes found in this research could inspire clinicians to discuss less obvious aspects of the experience of recovering with antipsychotics. Even more so, paying attention to the first-person perspective could lead to a more thorough understanding and benefit therapeutic relationships., (© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.)
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- 2024
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18. The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study.
- Author
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Quattrone D, Reininghaus U, Richards AL, Tripoli G, Ferraro L, Quattrone A, Marino P, Rodriguez V, Spinazzola E, Gayer-Anderson C, Jongsma HE, Jones PB, La Cascia C, La Barbera D, Tarricone I, Bonora E, Tosato S, Lasalvia A, Szöke A, Arango C, Bernardo M, Bobes J, Del Ben CM, Menezes PR, Llorca PM, Santos JL, Sanjuán J, Arrojo M, Tortelli A, Velthorst E, Berendsen S, de Haan L, Rutten BPF, Lynskey MT, Freeman TP, Kirkbride JB, Sham PC, O'Donovan MC, Cardno AG, Vassos E, van Os J, Morgan C, Murray RM, Lewis CM, and Di Forti M
- Subjects
- Humans, Linear Models, Risk Factors, Cannabis, Psychotic Disorders diagnosis, Psychotic Disorders genetics, Schizophrenia genetics
- Abstract
Diagnostic categories do not completely reflect the heterogeneous expression of psychosis. Using data from the EU-GEI study, we evaluated the impact of schizophrenia polygenic risk score (SZ-PRS) and patterns of cannabis use on the transdiagnostic expression of psychosis. We analysed first-episode psychosis patients (FEP) and controls, generating transdiagnostic dimensions of psychotic symptoms and experiences using item response bi-factor modelling. Linear regression was used to test the associations between these dimensions and SZ-PRS, as well as the combined effect of SZ-PRS and cannabis use on the dimensions of positive psychotic symptoms and experiences. We found associations between SZ-PRS and (1) both negative (B = 0.18; 95%CI 0.03-0.33) and positive (B = 0.19; 95%CI 0.03-0.35) symptom dimensions in 617 FEP patients, regardless of their categorical diagnosis; and (2) all the psychotic experience dimensions in 979 controls. We did not observe associations between SZ-PRS and the general and affective dimensions in FEP. Daily and current cannabis use were associated with the positive dimensions in FEP (B = 0.31; 95%CI 0.11-0.52) and in controls (B = 0.26; 95%CI 0.06-0.46), over and above SZ-PRS. We provide evidence that genetic liability to schizophrenia and cannabis use map onto transdiagnostic symptom dimensions, supporting the validity and utility of the dimensional representation of psychosis. In our sample, genetic liability to schizophrenia correlated with more severe psychosis presentation, and cannabis use conferred risk to positive symptomatology beyond the genetic risk. Our findings support the hypothesis that psychotic experiences in the general population have similar genetic substrates as clinical disorders., (© 2021. The Author(s).)
- Published
- 2021
- Full Text
- View/download PDF
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