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324 results on '"Betocchi, Sandro"'

1. Prognostic role of stress echocardiography in hypertrophic cardiomyopathy: The International Stress Echo Registry

Author

Ciampi, Quirino, Olivotto, Iacopo, Gardini, Chiara, Mori, Fabio, Peteiro, Jesus, Monserrat, Lorenzo, Fernandez, Xusto, Cortigiani, Lauro, Rigo, Fausto, Lopes, Luis Rocha, Cruz, Ines, Cotrim, Carlos, Losi, Mariangela, Betocchi, Sandro, Beleslin, Branko, Tesic, Milorad, Dikic, Ana Djordjevic, Lazzeroni, Ettore, Lazzeroni, Davide, Sicari, Rosa, and Picano, Eugenio

Published
2016
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2. Prognostic value of reduced heart rate reserve during exercise in hypertrophic cardiomyopathy

Author

Ciampi, Quirino, Olivotto, Iacopo, Peteiro, Jesus, D’Alfonso, Maria, Mori, Fabio, Tassetti, Luigi, Milazzo, Alessandra, Monserrat, Lorenzo, Fernandez, Xusto, Pálinkás, Attila, Pálinkás, Eszter, Sepp, Róbert, Re, Federica, Cortigiani, Lauro, Tesic, Milorad, Djordjevic-Dikic, Ana, Beleslin, Branko, Losi, Mariangela, Canciello, Grazia, Betocchi, Sandro, Lopes, Luis, Cruz, Ines, Cotrim, Carlos, Torres, Marco, Bellagamba, Clarissa, Heyning, Caroline Van De, Varga, Albert, Ágoston, Gergely, Villari, Bruno, Lorenzoni, Valentina, Carpeggiani, Clara, Picano, Eugenio, (SIECVI), the Stress Echo 2020 Study Group on behalf of the Italian Society of Echocardiography and Cardiovascular Imaging, Stress Echo 2020 Study Group, and Italian Society of Echocardiography and Cardiovascular Imaging (SIECVI)

Subjects
medicine.medical_specialty, Autonomic dysfunction, Hypertrophic cardiomyopathy, Stress echocardiography, lcsh:Medicine, Ventricular outflow tract obstruction, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, Heart rate, medicine, 030212 general & internal medicine, Treadmill, business.industry, lcsh:R, Hazard ratio, General Medicine, Odds ratio, medicine.disease, Quartile, Cardiology, Human medicine, medicine.symptom, business
Abstract

Background: Sympathetic dysfunction can be evaluated by heart rate reserve (HRR) with exercise test. Objectives: To determine the value of HRR in predicting outcome of patients with hypertrophic cardiomyopathy (HCM). Methods: We enrolled 917 HCM patients (age = 49 ± 15 years, 516 men) assessed with exercise stress echocardiography (ESE) in 11 centres. ESE modality was semi-supine bicycle in 51 patients (6%), upright bicycle in 476 (52%), and treadmill in 390 (42%). During ESE, we assessed left ventricular outflow tract obstruction (LVOTO), stress-induced new regional wall motion abnormalities (RWMA), and HRR (peak/rest heart rate, HR). By selection, all patients completed the follow-up. Mortality was the predetermined outcome measure Results: During ESE, RWMA occurred in 22 patients (2.4%) and LVOTO (≥50 mmHg) in 281 (30.4%). HRR was 1.90 ± 0.40 (lowest quartile ≤ 1.61, highest quartile &gt, 2.13). Higher resting heart rate (odds ratio 1.027, 95% CI: 1.018–1.036, p &lt, 0.001), older age (odds ratio 1.021, 95% CI: 1.009–1.033, p &lt, 0.001), lower exercise tolerance (mets, odds ratio 0.761, 95% CI: 0.708–0.817, p &lt, 0.001) and resting LVOTO (odds ratio 1.504, 95% CI: 1.043–2.170, p = 0.029) predicted a reduced HRR. During a median follow-up of 89 months (interquartile range: 36–145 months), 90 all-cause deaths occurred. At multivariable analysis, lowest quartile HRR (Hazard ratio 2.354, 95% CI 1.116–4.968 p = 0.025) and RWMA (Hazard ratio 3.279, 95% CI 1.441–7.461 p = 0.004) independently predicted death, in addition to age (Hazard ratio 1.064, 95% CI 1.043–1.085 p &lt, 0.001) and maximal wall thickness (Hazard ratio 1.081, 95% CI 1.037–1.128, p &lt, 0.001). Conclusions: A blunted HRR during ESE predicts survival independently of RWMA in HCM patients.

Published
2021

4. Implantable cardioverter-defibrillators and prevention of sudden cardiac death in hypertrophic cardiomyopathy

Author

Maron, Barry J., Spirito, Paolo, Win-Kuang Shen, Haas, Tammy S., Formisano, Francesco, Link, Mark S., Epstein, Andrew E., Almquist, Adrian K., Daubert, James P., Lawrenz, Thorsten, Boriani, Giuseppe, Estes, Mark N.A., III, Favale, Stefano, Piccininno, Marco, Winters, Stephen L., Santini, Massimo, Betocchi, Sandro, Buja, Gianfranco, Semsarian, Christopher, Bruzzi, Paolo, Arribas, Fernando, and Sherrid, Mark V.

Subjects
Cardiomyopathy, Hypertrophic -- Risk factors, Cardiomyopathy, Hypertrophic -- Prevention, Cardiomyopathy, Hypertrophic -- Care and treatment, Cardiac arrest -- Risk factors, Cardiac arrest -- Prevention
Abstract

Studies are conducted to determine the relationship between clinical risk profile and incidence and efficacy of the implantable cardioverter-defibrillator (ICD) intervention in hypertrophic cardiomyopathy (HCM). Results reveal that in a high-risk HCM cohort, ICD interventions for life-threatening ventricular tachyarrhythmias were frequent and highly effective in restoring normal rhythm.

Published
2007

5. The Italian registry for hypertrophic cardiomyopathy: a nationwide survey

Author

Cecchi, Franco, Olivotto, Iacopo, Betocchi, Sandro, Rapezzi, Claudio, Conte, Maria Rosa, Sinagra, Gianfranco, Zachara, Elisabetta, Gavazzi, Antonello, Rordorf, Roberto, Carnemolla, Gianfranco, Porcu, Maurizio, Nistri, Stefano, Gruppillo, Paolo, and Giampaoli, Simona

Subjects
Cardiomyopathy, Hypertrophic -- Research, Registries (in medicine) -- Evaluation, Italians -- Health aspects, Italians -- Surveys, Health surveys -- Reports, Health
Published
2005

8. Effect of left ventricular outflow tract obstruction on clinical outcome in hypertrophic cardiomyopathy

Author

Maron, Martin S., Olivotto, Iacopo, Betocchi, Sandro, Casey, Susan A., Lesser, John R., Losi, Maria A., Cecchi, Franco, and Maron, Barry J.

Subjects
Cardiomyopathy, Hypertrophic -- Patient outcomes, Cardiomyopathy, Hypertrophic -- Prognosis, Cardiomyopathy, Hypertrophic -- Complications, Heart failure -- Causes of
Abstract

Left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy increases the risk of heart failure and death, according to a study of 1,101 patients. Hypertrophic cardiomyopathy is characterized by an enlarged heart, which can compress the aorta and make it difficult for the heart to pump blood to the rest of the body. Left ventricular outflow tract obstruction is the medical term for this complication.

Published
2003

17. Myocardial Texture in Hypertrophic Cardiomyopathy

Author

Losi, Maria-Angela, Betocchi, Sandro, Chinali, Marcello, Barbati, Giovanni, DʼAlessandro, Gianluigi, Cacace, Alessandra, Lombardi, Raffaella, Contaldi, Carla, de Simone, Giovanni, and Chiariello, Massimo

Published
2007

25. Percutaneous treatment of patients with heart diseases: selection, guidance and follow-up. A review

Author

Contaldi Carla, Losi Maria-Angela, Rapacciuolo Antonio, Prastaro Maria, Lombardi Raffaella, Parisi Valentina, Parrella Lucia S, Di Nardo Carlo, Giamundo Alessandra, Puglia Roberto, Esposito Giovanni, Piscione Federico, and Betocchi Sandro

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Aortic stenosis and mitral regurgitation, patent foramen ovale, interatrial septal defect, atrial fibrillation and perivalvular leak, are now amenable to percutaneous treatment. These percutaneous procedures require the use of Transthoracic (TTE), Transesophageal (TEE) and/or Intracardiac echocardiography (ICE). This paper provides an overview of the different percutaneous interventions, trying to provide a systematic and comprehensive approach for selection, guidance and follow-up of patients undergoing these procedures, illustrating the key role of 2D echocardiography.

Published
2012
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26. Echocardiography in patients with hypertrophic cardiomyopathy: usefulness of old and new techniques in the diagnosis and pathophysiological assessment

Author

D'Andrea Antonello, Buralli Simona, Ballo Piercarlo, Agricola Eustachio, Olivotto Iacopo, Cecchi Franco, Betocchi Sandro, Galderisi Maurizio, Nistri Stefano, Losi Maria-Angela, D'Errico Arcangelo, Mele Donato, Sciomer Susanna, and Mondillo Sergio

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Abstract Hypertrophic cardiomyopathy (HCM) is one of the most common inherited cardiomyopathy. The identification of patients with HCM is sometimes still a challenge. Moreover, the pathophysiology of the disease is complex because of left ventricular hyper-contractile state, diastolic dysfunction, ischemia and obstruction which can be coexistent in the same patient. In this review, we discuss the current and emerging echocardiographic methodology that can help physicians in the correct diagnostic and pathophysiological assessment of patients with HCM.

Published
2010
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30. Effects of intravenous verapamil on left ventricular relaxation and filling in stable angina pectoris

Author

Betocchi, Sandro, Piscione, Federico, Perrone-Filardi, Pasquale, Pace, Leonardo, Cappelli-Bigazzi, Maurizio, Alfano, Bruno, Ciarmiello, Andrea, Salvatore, Marco, Condorelli, Mario, and Chiariello, Massimo

Subjects
Calcium channel blockers -- Physiological aspects, Heart failure -- Causes of, Angina pectoris -- Drug therapy, Heart ventricle, Left -- Physiological aspects, Verapamil -- Physiological aspects, Health
Abstract

Left ventricular (LV) diastolic function is often impaired in coronary artery disease (CAD). To assess whether verapamil could improve LV diastolic properties, 12 patients with CAD undergoing right-and left-sided cardiac catheterization, as well as simultaneous radionuclide angiography, were studied before and during intravenous administration of verapamil (0.1 mg/kg as a bolus followed by 0.007 mg/kg/min). The heart rate was kept constant by atrial pacing in both studies. LV pressure-volume relations were obtained. Verapamil decreased LV systolic pressure (130 [+ or -] 22 to 117 [+ or -] 16 mm Hg, p (Am J Cardiol 1990;66:818-825), Left ventricular (LV) diastolic function refers to the relaxation phase of the heartbeat, specifically when the left atrium contracts and oxygenated blood flows into the relaxed LV chamber. Angina pectoris (chest pain caused by decreased blood flow to the heart) can impair this function by slowing ventricular relaxation and reducing early filling of the LV. This diastolic dysfunction may induce symptoms of congestive heart failure even when ventricular systolic function (the ability to pump oxygenated blood into the systemic circulation) is normal. The authors investigated whether treatment with verapamil, a calcium channel blocker usually used to treat angina, would reverse diastolic dysfunction. Verapamil is known to improve LV relaxation and filling for some conditions, and noninvasive studies had reported similar effects in patients with coronary artery disease (CAD). It was important to determine whether verapamil-related improvements in LV relaxation and filling were the result of improved diastolic function or increased filling pressure. Twelve patients with CAD, who were undergoing diagnostic heart catheterization and angiography (X-ray), were studied before and during intravenous administration of verapamil. When measurements were being taken, the heart rate was kept constant by a cardiac pacemaker. Comparison with a control group was not possible because healthy people could not be subjected to such invasive procedures. The results of the study indicate that administration of verapamil is useful in treating coronary artery disease. Its effects on the myocardium, or heart muscle, improved LV relaxation and, thereby, increased the peak filling rate. Verapamil also led to a higher preload, resulting in enhanced filling, and reduced afterload, resulting in improved relaxation. Therefore, verapamil affects LV function and early filling as a result of both direct action on the heart muscle and changes in load. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

33. Special problems in patients with prosthetic heart valves

Author

BETOCCHI, SANDRO, LOSI, MARIA ANGELA, CHIARIELLO, MASSIMO, MH. Crawford, JP. DiMarco, WJ. Paulus, Betocchi, Sandro, Losi, MARIA ANGELA, Chiariello, Massimo, CRAWFORD ME, DI MARCO J, and PAULUS W

Subjects
diastolic function, heart valve, pregnancy
Published
2010

34. Aortic valve sclerosis in patients with peripheral and/or coronary arterial disease

Author

LOSI, MARIA ANGELA, BREVETTI, GREGORIO, SCHIANO, VITTORIO, PARISI, VALENTINA, CONTALDI, CARLA, CHIACCHIO, ELENA, CAVALLARO, MARIA, CARPINELLA, GERARDO, PARRELLA, LUCIA SERENA, BETOCCHI, SANDRO, BREVETTI, LINDA, CHIARIELLO, MASSIMO, Barbati G, Fundaliotis A, Losi, MARIA ANGELA, Brevetti, Gregorio, Schiano, Vittorio, Barbati, G, Parisi, Valentina, Contaldi, Carla, Chiacchio, Elena, Cavallaro, Maria, Carpinella, Gerardo, Fundaliotis, A, Parrella, LUCIA SERENA, Betocchi, Sandro, Brevetti, Linda, and Chiariello, Massimo

Subjects
atherosclerosi, aortic valve
Published
2010

35. Prognostic significance of left atrial size in patients with hypertrophic cardiomyopathy (from the Italian Registry for Hypertrophic Cardiomyopathy)

Author

NISTRI S, OLIVOTTO I, VALSECCHI G, PINAMONTI B, CONTE MR, CASAZZA F, MARON BJ, CECCHI F, ON BEHALF PARTICIPATING CENTERS, BETOCCHI, SANDRO, LOSI, MARIA ANGELA, GALDERISI, MAURIZIO, Nistri, S, Olivotto, I, Betocchi, Sandro, Losi, MARIA ANGELA, Valsecchi, G, Pinamonti, B, Conte, Mr, Casazza, F, Galderisi, Maurizio, Maron, Bj, Cecchi, F, and ON BEHALF PARTICIPATING, Centers

Subjects
Adult, Male, medicine.medical_specialty, Heart disease, Cardiomyopathy, Severity of Illness Index, Sudden death, Ventricular Outflow Obstruction, Cohort Studies, Sex Factors, Predictive Value of Tests, Internal medicine, Atrial Fibrillation, medicine, Humans, Heart Atria, Registries, Ultrasonography, Heart Failure, business.industry, Age Factors, Hypertrophic cardiomyopathy, Atrial fibrillation, Cardiomyopathy, Hypertrophic, Middle Aged, Prognosis, medicine.disease, Italy, Predictive value of tests, Heart failure, Multivariate Analysis, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, Biomarkers, Follow-Up Studies, Cohort study
Abstract

This study assessed left atrial (LA) dimension as a potential predictor of outcome in hypertrophic cardiomyopathy (HC). From the Italian Registry for Hypertrophic Cardiomyopathy, 1,491 patients (mean age 47 +/- 17 years; 61% men; 19% obstructive), followed for 9.4 +/- 7.4 years after the initial echocardiographic evaluation, constituted the study group. The mean LA transverse dimension was 43 +/- 9 mm and was larger in patients with severe symptoms (48 +/- 9 mm for New York Heart Association classes III and IV vs 42 +/- 9 mm for classes I and II, p0.001), atrial fibrillation (47 +/- 9 vs 42 +/- 8 mm in sinus rhythm, p0.001), and left ventricular outflow obstruction (46 +/- 9 mm foror=30 mm Hg at rest vs 42 +/- 9 mm for30 mm Hg at rest, p0.001). On univariate analysis, each 5-mm increase in LA size was associated with a hazard ratio (HR) of 1.2 for all-cause mortality (p0.0001). On multivariate analysis, a LA dimension48 mm (the 75th percentile) had a HR of 1.9 for all-cause mortality (p = 0.008), 2.0 for cardiovascular death (p = 0.014), and 3.1 for death related to heart failure (p = 0.008) but was unassociated with sudden death (p = 0.81). Similar results were obtained after the exclusion of patients with atrial fibrillation (HR 1.7, p = 0.008) or outflow obstruction (HR 1.8, p = 0.003). The predictive power of LA dimension48 mm was also validated in an independent HC cohort from the United States, with similar HRs (1.8 for all-cause mortality, p = 0.019). In conclusion, in a large cohort of patients with HC from a nationwide registry, a marked increase in LA dimension were predictive of long-term outcome, independent of co-existent atrial fibrillation or outflow obstruction. LA dimension is a novel and independent marker of prognosis in HC, particularly relevant to the identification of patients at risk for death related to heart failure.

Published
2006

36. Long-term effects of surgical septal myectomy on survival in patients with obstructive hypertrophic cardiomyopathy

Author

OMMEN SR, MARON BJ, OLIVOTTO I, MARON MS, CECCHI F, GERSH BJ, ACKERMAN MJ, MCCULLY RB, DEARANI JA, SCHAFF HV, DANIELSON GK, TAJIK AJ, NISHIMURA R.A., BETOCCHI, SANDRO, Ommen, Sr, Maron, Bj, Olivotto, I, Maron, M, Cecchi, F, Betocchi, Sandro, Gersh, Bj, Ackerman, Mj, Mccully, Rb, Dearani, Ja, Schaff, Hv, Danielson, Gk, Tajik, Aj, and Nishimura, R. A.

Subjects
Cardiomiopatia ipertrofica
Abstract

OBJECTIVES This study sought to determine the impact of surgical myectomy on long-term survival in hypertrophic cardiomyopathy (HCM).BACKGROUND Left ventricular (LV) outflow tract obstruction in HCM increases the likelihood of heart failure and cardiovascular death. Although surgical myectomy is the primary treatment for amelioration of outflow obstruction and advanced drug-refractory heart failure symptoms, its impact on long-term survival remains unresolved.METHODS Total and HCM-related mortality were compared in three subgroups comprised of 1,337 consecutive HCM patients evaluated from 1983 to 2001: 1) surgical myectomy (n = 289); 2) LV outflow obstruction without operation (n = 228), and 3) nonobstructive (n = 820). Mean follow-up duration was 6 6 years.RESULTS Including two operative deaths (procedural mortality, 0.8%), 1-, 5-, and 10-year overall survival after myectomy was 98%, 96%, and 83%, respectively, and did not differ from that of the general U.S. population matched for age and gender (p = 0.2) nor from patients with nonobstructive HCM (p = 0.8). Compared to nonoperated obstructive HCM patients, myectomy patients experienced superior survival free from all-cause mortality (98%, 96%, and 83% vs. 90%, 79%, and 61%, respectively, p < 0.001), HCM-related mortality (99%, 98%, and 95% vs. 94%, 89%, and 73%, respectively, p < 0.001), and sudden cardiac death (100%, 99%, and 99% vs. 97%, 93%, and 89%, respectively, p = 0.003). Multivariate analysis showed myectomy to have a strong, independent association with survival (hazard ratio 0.43; p < 0.001).CONCLUSIONS Surgical myectomy performed to relieve outflow obstruction and severe symptoms in HCM was associated with long-term survival equivalent to that of the general population, and superior to obstructive HCM without operation. In this retrospective study, septal myectomy seems to reduce mortality risk in severely symptomatic patients with obstructive HCM.

Published
2005

41. Efficacy of implantable cardioverter-defibrillators for the prevention of sudden death in patients with hypertrophic cardiomyopathy

Author

MARON B. J., SHEN W. K., LINK M. S., EPSTEIN A. E., ALMQUIST AK, DAUBERT JP, BARDY GH, FAVALE S, REA RF, BORIANI G, ESTES NA, SPIRITO P, CASEY SA, STENTON MS, BETOCCHI, SANDRO, Maron, B. J., Shen, W. K., Link, M. S., Epstein, A. E., Almquist, Ak, Daubert, Jp, Bardy, Gh, Favale, S, Rea, Rf, Boriani, G, Estes, Na, Spirito, P, Casey, Sa, Stenton, M, and Betocchi, Sandro

Published
2000

48. Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy

Author

Roncarati, Roberta, primary, Viviani Anselmi, Chiara, additional, Losi, Maria Angela, additional, Papa, Laura, additional, Cavarretta, Elena, additional, Da Costa Martins, Paula, additional, Contaldi, Carla, additional, Saccani Jotti, Gloria, additional, Franzone, Anna, additional, Galastri, Laura, additional, Latronico, Michael V.G., additional, Imbriaco, Massimo, additional, Esposito, Giovanni, additional, De Windt, Leon, additional, Betocchi, Sandro, additional, and Condorelli, Gianluigi, additional

Published
2014
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