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Your search keyword '"Blaha, Gregory"' showing total 22 results
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22 results on '"Blaha, Gregory"'

2. Durability and Efficacy of Faricimab in Treatment‐Resistant Retinal Edema Utilizing "Real‐World" Dosing Regimens.

Author

Savant, Shravan V., Kwan, James T., Barouch, Fina, Chang, Jeffrey, Ramsey, David J., Marx, Jeffrey, Blaha, Gregory, Klein-Mascia, Kendra, and Yesilirmak, Nilufer

Subjects
DIABETES complications, THERAPEUTIC use of monoclonal antibodies, PHARMACEUTICAL arithmetic, MEDICAL protocols, DIABETIC retinopathy, INTRAVITREAL injections, ENDOTHELIAL growth factors, OPTICAL coherence tomography, INTRAOCULAR pressure, TREATMENT effectiveness, RETROSPECTIVE studies, CHI-squared test, MACULAR edema, MONOCLONAL antibodies, DRUG efficacy, PATHOLOGIC neovascularization, VISUAL acuity, EVALUATION
Abstract

Purpose: To retrospectively analyze clinical outcomes of patients with "treatment‐resistant" neovascular age‐related macular degeneration or diabetic macular edema who were switched to intravitreal faricimab injections (IFIs) using a "real‐world" treat‐and‐extend (TAE) protocol. Methods: Seventy‐one eyes from 62 patients receiving antivascular endothelial growth factor injections were evaluated before and after switching to IFI. Demographic and clinical data were collected. Primary endpoints were treatment interval extension and presence of intraretinal or subretinal fluid on spectral‐domain optical coherence tomography (OCT) after switching to IFI. Secondary endpoints included best‐corrected visual acuity, average OCT central subfield thickness, and presence of a pigment epithelium detachment and pigment epithelium detachment height. Results: The average treatment interval after switching to IFI significantly increased from 37.6 ± 10.8 days to 45.2 ± 16.6 days (p = 0.0016). At the last follow‐up, 35% of eyes were able to achieve a fluid‐free status post‐IFI. A chi‐square test of independence validated this finding by showing a significant difference in the OCT findings trending towards less or no fluid on follow‐up (X2 [3, N = 71] = 13.0705; p = 0.0003). The average central subfield thickness decreased from 327.2 ± 89.1 μm to 294.8 ± 86.5 μm (p = 0.0294). Best‐corrected visual acuity, intraocular pressure, pigment epithelium detachment presence, and height had no significant difference after switching to IFI. Conclusions: In "treatment‐resistant" patients receiving anti‐VEGF therapy for neovascular age‐related macular degeneration or diabetic macular edema, switching to IFI in a "real‐world" TAE protocol led to statistically significant improvements in treatment interval and retinal fluid on spectral domain OCT. [ABSTRACT FROM AUTHOR]

Published
2024
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3. DESIGN OF EXPERIMENTS (DOE) FOR NON-SPECIALISTS IN STATISTICS IN THE FOOD INDUSTRY: TRIALS WITH POPCORN.

Author

de Moura, Roque Antônio, Alves Santos, David Felipe, Goussain, Blaha Gregory S., de Oliveira, Márcia Regina, and Silva, Messias Borges

Subjects
EXPERIMENTAL design, DEPENDENT variables, MATHEMATICAL models, INDUSTRIAL statistics, STATISTICS
Abstract

Copyright of Environmental & Social Management Journal / Revista de Gestão Social e Ambiental is the property of Environmental & Social Management Journal and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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10. Early Conversion to Aflibercept for Persistent Diabetic Macular Edema Results in Better Visual Outcomes and Lower Treatment Costs

Author

Ramsey,David, Poulin,Samuel J, LaMonica,Lauren C, Blaha,Gregory R, Barouch,Fina C, Chang,Jeffrey, Marx,Jeffrey L, Ramsey,David, Poulin,Samuel J, LaMonica,Lauren C, Blaha,Gregory R, Barouch,Fina C, Chang,Jeffrey, and Marx,Jeffrey L

Abstract

David J Ramsey,1,* Samuel J Poulin,1,* Lauren C LaMonica,2 Gregory R Blaha,1 Fina C Barouch,1 Jeffrey Chang,1 Jeffrey L Marx1 1Division of Ophthalmology, Lahey Hospital & Medical Center, Tufts University School of Medicine, Peabody, MA 01960, USA; 2University of Michigan Medical School, Ann Arbor, MI 48109, USA*These authors contributed equally to this workCorrespondence: David J RamseyLahey Hospital & Medical Center, Tufts University School of Medicine, 1 Essex Center Drive, Peabody, MA 01960, USAEmail David.J.Ramsey@lahey.orgPurpose: To evaluate the functional and anatomic outcomes, as well as cost-effectiveness, of the timing of conversion to intravitreal aflibercept (IVA) in patients with treatment-resistant diabetic macular edema (DME).Methods: Thirty consecutive eyes (25 patients) were identified that were treated with ≥ 3 intravitreal bevacizumab (IVB) and/or ranibizumab (IVR) injections prior to treatment with ≥ 3 IVA injections. Eyes that received ≤ 6 IVB and/or IVR injections (early-switch) were compared to those that received ≥ 7 injections (late-switch) prior to conversion to IVA. Treatment effectiveness was measured in quality-adjusted life years (QALYs). A micro-simulation model examined the impact of treatment duration on outcomes.Results: Early- (n=18) and late- (n=12) switch eyes had similar vision prior to conversion to IVA. Despite improvements in retinal thickness, only the early-switch eyes maintained vision gains after conversion to IVA through the end of follow-up (p=0.027). Early switch saved $22,884/eye and produced an additional 0.027 QALYs.Conclusion: Early conversion to IVA optimizes vision outcomes and results in lower overall treatment expenditures.Keywords: diabetic macular edema; DME, socioeconomics, diabetic retinopathy

Published
2021

20. BDNF administration after traumatic brain injury in the rat

Author

Blaha, Gregory Robert and Blaha, Gregory Robert

Abstract

Brain-derived neurotrophic factor (BDNF) has been shown to have numerous cellular effects and to be protective in a wide variety of experimental insults, including excitotoxicity, axotomy and ischemia. The present study examined whether BDNF could be a potential treatment for traumatic brain injury (TBI) using the lateral fluid-percussion (LFP) model in the rat. BDNF was infused into either the hippocampus or the cortex (at one of two different doses) starting 3–4 hours after injury and continuing for 2 weeks. Animals were evaluated by means of the following outcome measures: neurological motor ability at 2 days, 1 week, and 2 weeks; learning and memory in a water maze at 2 weeks; neuronal loss in the CA3, dentate hilus, and medial geniculate nucleus at 2 weeks; and size of cortical lesion at two weeks. A significant effect of injury was seen in all of the above measures, however BDNF treatment was not able to significantly improve any of these deficits when compared to vehicle-infusion.

Published
2000

21. Man complains of foggy vision, photosensitivity.

Author

Tawse, Kirstin L. and Blaha, Gregory R.

Subjects
BEVACIZUMAB, CHRONIC myeloid leukemia, OPHTHALMIC drugs, ANEURYSMS, ANGIOGRAPHY, DIFFERENTIAL diagnosis, ECHOCARDIOGRAPHY, MEDICAL history taking, RETINAL diseases, ULTRASONIC imaging, DISEASE progression, VISION disorders, SYMPTOMS, DIAGNOSIS, THERAPEUTICS
Abstract

The article discusses the case of a 68-year-old man who complained of intermittent foggy vision in both eyes and increased photosensitivity. The patient's medical history is provided as well as his medications for diabetes mellitus. Results of several examinations performed on the patients are discussed including anterior segment and fluorescein angiography. The differential diagnosis of white-centered retinal hemorrhages is discussed.

Published
2013

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