385 results on '"Bolli, Martin"'
Search Results
2. Assessment of resectability of pancreatic cancer using novel immersive high-performance virtual reality rendering of abdominal computed tomography and magnetic resonance imaging
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Kunz, Julia Madlaina, Maloca, Peter, Allemann, Andreas, Fasler, David, Soysal, Savas, Däster, Silvio, Kraljević, Marko, Syeda, Gulbahar, Weixler, Benjamin, Nebiker, Christian, Ochs, Vincent, Droeser, Raoul, Walker, Harriet Louise, Bolli, Martin, Müller, Beat, Cattin, Philippe, and Staubli, Sebastian Manuel
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- 2024
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3. Netze für den ösophagealen Hiatus
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Angehrn, Fiorenzo Valente, von Flüe, Markus, Bolli, Martin, Kudsi, Omar Yusef, editor, Dietz, Ulrich A., editor, Beldi, Guido, editor, Fortelny, René, editor, and Wiegering, Armin, editor
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- 2024
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4. The short- and long-term outcome after the surgical management of common bile duct stones in a tertiary referral hospital
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Hess, Gabriel F., Sedlaczek, Philipp, Zeindler, Jasmin, Muenst, Simone, Schmitt, Andreas M., Däster, Silvio, Bolli, Martin, Kollmar, Otto, and Soysal, Savas D.
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- 2023
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5. Local ablative therapies and the effect on antitumor immune responses in pancreatic cancer – A review
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Erdem, Suna, Narayanan, Jayanth Shankara, Worni, Mathias, Bolli, Martin, and White, Rebekah R.
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- 2024
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6. Trends in pancreatic surgery in Switzerland: a survey and nationwide analysis over two decades
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Kuemmerli, Christoph, Schneider, Marcel André, Joliat, Gaëtan-Romain, Moeckli, Beat, Ukegjini, Kristjan, Bolli, Martin, Worni, Mathias, and Birrer, Dominique Lisa
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- 2022
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7. Continuously sutured versus linear-stapled anastomosis in robot-assisted hybrid Ivor Lewis esophageal surgery following neoadjuvant chemoradiotherapy: a single-center cohort study
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Angehrn, Fiorenzo V., Neuschütz, Kerstin J., Fourie, Lana, Becker, Pauline, von Flüe, Markus, Steinemann, Daniel C., and Bolli, Martin
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- 2022
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8. Interprofessional differences in preoperative planning—the individualist surgeon
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Haak, Fabian, Poletti, Tino, Grossman, Nir, von Holzen, Urs, Bolli, Martin, Klasen, Jennifer M., Glass, Tracy, and von Strauss und Torney, Marco
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- 2022
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9. Robotic versus laparoscopic low anterior resection following neoadjuvant chemoradiation therapy for stage II–III locally advanced rectal cancer: a single-centre cohort study
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Angehrn, Fiorenzo V., Schneider, Romano, Wilhelm, Alexander, Daume, Diana, Koechlin, Luca, Fourie, Lana, von Flüe, Markus, Kern, Beatrice, Steinemann, Daniel C., and Bolli, Martin
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- 2022
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10. Laparoscopic versus robotic-assisted, left-sided colectomies: intra- and postoperative outcomes of 683 patients
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Gass, Jörn-Markus, Daume, Diana, Schneider, Romano, Steinemann, Daniel, Mongelli, Francesco, Scheiwiller, Andreas, Fourie, Lana, Kern, Beatrice, von Flüe, Markus, Metzger, Jürg, Angehrn, Fiorenzo, and Bolli, Martin
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- 2022
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11. From open Ivor Lewis esophagectomy to a hybrid robotic-assisted thoracoscopic approach: a single-center experience over two decades
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Angehrn, Fiorenzo V., Neuschütz, Kerstin J., Fourie, Lana, Wilhelm, Alexander, Däster, Silvio, Ackermann, Christoph, von Flüe, Markus, Steinemann, Daniel C., and Bolli, Martin
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- 2022
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12. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries
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Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, Ahmed, Saqr, Amira M, Abdelelsalm, Wafaa M, Elshennawy, Eslam M, Radwan, Samar T, Awad, Selmy S, Emile, Sameh H, Aldosoky, Wesam A, Elfeki, Hossam, Gendi, Sara N, Abdelsalam, Hala Adel, Hammad, Mohammed, Shalaby, Mostafa, Sakr, Ahmad Hammad, Abdelmaksoud, Mohamed A, Alawady, Mohammed, Omran, Abdelrahman Azzam, Allam, Abdallah R, Ismail, Zainab, Gaballah, Khaled M, AlGady, Mahmoud Fathy Mahmoud, Raslan, Ahmed M, Gharbia, Khaled, Nuser, Abdelazez A, Sayed, Ahmed Kamal, Elshahawy, Mahmoud A, Ghaly, Galal, Sherif, Ahmed Elshawadfy, Makram, Abdelrahman M, Makram, Omar M, Ahmed, Ola, Helmy, AbdelRahman M A, Abdelwahab, Khaled M, Abdelkhalek, Mohamed, Metwally, Islam H, Shetiwy, Mosab Saad, Zuhdy, Mohammad, Ramadan, Salma I, Abdelghany, Mohamed, Omar, Mohammed A, Soliman, Ziad A, Ali, Hossam T, Elnoamany, Salma, Ghozy, Sherief, Abbas, Alzhraa S, Shehata, Mostafa A, Mahmoud, Sahar A, Elsaman, Mohammed A, Fayad, Elsayed A, Radwan, Asmaa, El-Sakka, Ahmed I, Sallam, Asser, Elbahnasawy, Mohamed G, Esmail, Eslam S, Hawila, Ahmed Maher, Hamada, Mohamed K, Motawea, Sara H, Morsy, Mohamed S, El-Sheemy, Hatem Refaat, Ebada, Mahmoud Ahmed, Khedr, Ali H, Gad, Ahmed, Elmandouh, Omar, Elmandouh, Reem, Alkanj, Souad, Youssef, Mohammad G, Awad, Kamal, Mohammed, Maged, Elsayad, Ahmed H, Rätsep, Tõnu, Wolle, Melatework A, Negussie, Abraham G, Adimass, Misganaw A, Misganaw, Bereket Tsegaye, Bezabih, Yoseph S, Assefa, Biniam Zemedu, Shumye, Getachew W, Mengesha, Mengistu G, Gechera, Dagnachew Y, Mohammed, Adnan A, Mulugeta, Gersam A, Metaferia, Yonas Y, Kifetew, Ashebir B, Degefa, Eyueal A, Deressa, Yadani M, Gonfa, Kebebe Bekele, Bedane, Zewdie G, Ayalew, Alem M, Ayele, Henok Teshome, Abebe, Engida, Worku, Bereket Atnafu, Sisay, Million M, Kassa, Dawit Worku, Awedew, Atalel F, Bayable, Abera C, Tiruneh, Abraham Genetu, Hailu, Samuel, Numaro, Yilkal T, Ademe, Yonas, Baleh, Abat S, Megerssa, Thomas B, Kejela, Segni, Derilo, Habtamu T, Akililu, Yemisirach B, Lebbe, Iris, Sarjanoja, Elise K, 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- 2022
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13. Persistent acute cholecystitis after cholecystostomy – increased mortality due to treatment approach?
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Hess, Gabriel F., Sedlaczek, Philipp, Haak, Fabian, Staubli, Sebastian M., Muenst, Simone, Bolli, Martin, Zech, Christoph J., Hoffmann, Martin H., Mechera, Robert, Kollmar, Otto, and Soysal, Savas D.
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- 2022
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14. From laparoscopic to robotic-assisted Heller myotomy for achalasia in a single high-volume visceral surgery center: postoperative outcomes and quality of life
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Gass, Jörn-Markus, Cron, Lucien, Mongelli, Francesco, Tartanus, Justyna, Angehrn, Fiorenzo Valente, Neuschütz, Kerstin, von Flüe, Markus, Fourie, Lana, Steinemann, Daniel, and Bolli, Martin
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- 2022
- Full Text
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15. Impact of Positive Lymph Nodes after Systematic Perihilar Lymphadenectomy in Colorectal Liver Metastases.
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Hess, Gabriel F., Aegerter, Noa L. E., Zeindler, Jasmin, Vosbeck, Jürg, Neuschütz, Kerstin J., Müller, Philip C., Muenst, Simone, Däster, Silvio, Bolli, Martin, Kollmar, Otto, and Soysal, Savas D.
- Subjects
COLORECTAL liver metastasis ,LYMPHATIC metastasis ,LYMPH node surgery ,LYMPHADENECTOMY ,OVERALL survival - Abstract
Background: 25 to 50% of patients suffering from colorectal cancer develop liver metastases. The incidence of regional lymph node (LN) metastases within the liver is up to 14%. The need for perihilar lymph node dissection (LND) is still a controversial topic in patients with colorectal liver metastases (CRLM). This study investigates the role of perihilar LND in patients with CRLM. Methods: For this retrospective study, patients undergoing surgery for CRLM at the University Hospital Basel between May 2009 and December 2021 were included. In patients with perihilar LND, LN were stained for CK22 and examined for single tumour cells (<0.2 mm), micro- (0.2–2 mm), and macro-metastases (>2 mm). Results: 112 patients undergoing surgery for CRLM were included. 54 patients underwent LND, 58/112 underwent liver resection only (LR). 3/54 (5.6%) showed perihilar LN metastases in preoperative imaging, and in 10/54 (18.5%), micro-metastases could be proven after CK22 staining. Overall complications were similar in both groups (LND: 46, 85.2%; LR: 48, 79.3%; p = 0.800). The rate of major complications was higher in the LND group (LND: 22, 40.7%; LR: 18, 31%, p = 0.002). Median recurrence-free survival (RFS) (LND: 10 months; LR: 15 months, p = 0.076) and overall survival (OS) were similar (LND: 49 months; LR: 60 months, p = 0.959). Conclusion: Preoperative imaging is not sensitive enough to detect perihilar LN metastases. Perihilar LND enables precise tumour staging by detecting more lymph node metastases, especially through CK22 staining. However, perihilar LND does not influence oncologic outcomes in patients with CRLM. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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- View/download PDF
16. Robot-assisted vs. laparoscopic repair of complete upside-down stomach hiatal hernia (the RATHER-study): a prospective comparative single center study
- Author
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Wilhelm, Alexander, Nocera, Fabio, Schneider, Romano, Koechlin, Luca, Daume, Diana L., Fourie, Lana, Steinemann, Daniel, von Flüe, Markus, Peterli, Ralph, Angehrn, Fiorenzo V., and Bolli, Martin
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- 2022
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17. Long-term quality of life after hybrid robot-assisted and open Ivor Lewis esophagectomy for esophageal cancer in a single center: a comparative analysis
- Author
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Neuschütz, Kerstin J., primary, Fourie, Lana, additional, Germann, Nicolas, additional, Pieters, Anouk, additional, Däster, Silvio, additional, Angehrn, Fiorenzo V., additional, Klasen, Jennifer M., additional, Müller-Stich, Beat P., additional, Steinemann, Daniel C., additional, and Bolli, Martin, additional
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- 2024
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18. Chronische Diarrhoe und Ulzera duodeni – was steckt dahinter?
- Author
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Rebell, Claudia, primary, Bolli, Martin, additional, Reichmann, Jan, additional, Bieg, Christian, additional, and Manz, Michael, additional
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- 2024
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19. Diarrhée chronique et ulcères duodénaux – qu’est-ce qui se cache derrière?
- Author
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Rebell, Claudia, primary, Bolli, Martin, additional, Reichmann, Jan, additional, Bieg, Christian, additional, and Manz, Michael, additional
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- 2024
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- View/download PDF
20. Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P 1 modulator ponesimod
- Author
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Treiber, Alexander, primary, Seeland, Swen, additional, Segrestaa, Jérôme, additional, Lescop, Cyrille, additional, and Bolli, Martin H., additional
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- 2024
- Full Text
- View/download PDF
21. Anatomic versus non‐anatomic liver resection for hepatocellular carcinoma—A European multicentre cohort study in cirrhotic and non‐cirrhotic patients
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Zeindler, Jasmin, primary, Hess, Gabriel Fridolin, additional, von Heesen, Maximilian, additional, Aegerter, Noa, additional, Reber, Cornelia, additional, Schmitt, Andreas Michael, additional, Muenst, Simone, additional, Bolli, Martin, additional, Soysal, Savas Deniz, additional, and Kollmar, Otto, additional
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- 2024
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22. Discovery of a Novel Orally Active, Selective LPA Receptor Type 1 Antagonist, 4-(4-(2-Isopropylphenyl)-4-((2-methoxy-4-methylphenyl)carbamoyl)piperidin-1-yl)-4-oxobutanoic Acid, with a Distinct Molecular Scaffold
- Author
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Lescop, Cyrille, primary, Brotschi, Christine, additional, Williams, Jodi T., additional, Sager, Christoph P., additional, Birker, Magdalena, additional, Morrison, Keith, additional, Froidevaux, Sylvie, additional, Delahaye, Stéphane, additional, Nayler, Oliver, additional, and Bolli, Martin H., additional
- Published
- 2024
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23. Discovery of the Novel, Orally Active, and Selective LPA1 Receptor Antagonist ACT-1016-0707 as a Preclinical Candidate for the Treatment of Fibrotic Diseases
- Author
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Lescop, Cyrille, primary, Birker, Magdalena, additional, Brotschi, Christine, additional, Bürki, Cédric, additional, Morrison, Keith, additional, Froidevaux, Sylvie, additional, Delahaye, Stéphane, additional, Nayler, Oliver, additional, and Bolli, Martin H., additional
- Published
- 2024
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24. Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707
- Author
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Davenport, Raffael, primary, Masse, Florence, additional, Prud’homme, Alice, additional, Bürki, Cédric, additional, Doerrwaechter, Patric, additional, Künzli, Marco, additional, D’Aiuto, Fabio, additional, Bolli, Martin H., additional, and Schäfer, Gabriel, additional
- Published
- 2024
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25. Bile Salt Export Pump (BSEP) Inhibition
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Treiber, Alexander, primary and Bolli, Martin H., additional
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- 2021
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26. Local ablative therapies and the effect on antitumor immune responses in pancreatic cancer – A review
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Erdem, Suna, primary, Narayanan, Jayanth Shankara, additional, Worni, Mathias, additional, Bolli, Martin, additional, and White, Rebekah R., additional
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- 2023
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27. Role of lymphadenectomy in resectable pancreatic cancer
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Erdem, Suna, Bolli, Martin, Müller, Sascha A., von Flüe, Markus, White, Rebekah, and Worni, Mathias
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- 2020
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28. Reversible oxidation/reduction steps in the metabolic degradation of the glycerol side chain of the S1P1 modulator ponesimod.
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Treiber, Alexander, Seeland, Swen, Segrestaa, Jérôme, Lescop, Cyrille, and Bolli, Martin H.
- Subjects
ALCOHOL oxidation ,CHEMICAL decomposition ,LIVER microsomes ,GLYCERIN ,CHEMICAL reactions ,INTERFERON beta 1b - Abstract
1. Ponesimod is a selective modulator of the sphingosine 1-phosphate receptor 1 (S1P
1 ) approved for the treatment of active relapsing forms of multiple sclerosis. The chemical structure of ponesimod contains a glycerol side chain which is the major target of drug metabolism in humans. 2. The two major metabolic pathways give the acids M12 (-OCH2 CH(OH)COOH) and M13 (-OCH2 COOH). While the former results from oxidation of the terminal alcohol, the mechanism yielding the chain-shortened acid M13 is less obvious. A detailed mechanistic study with human liver microsomes and hepatocytes using ponesimod, M12 and some of the suspected intermediates revealed an unexpectedly complex pattern of enzyme-mediated and chemical reactions. 3. Metabolic pathways for both acids were not independent and several of the transformations were reversible, depending on reaction conditions. Formation of M13 occurred either via initial oxidation of the secondary alcohol, or as a downstream process starting from M12. 4. The phenol metabolite M32 was produced as part of several pathways. Control experiments at various pH values and in the absence of metabolising enzymes support the conclusion that its formation resulted from chemical degradation rather than from metabolic processes. [ABSTRACT FROM AUTHOR]- Published
- 2024
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29. Discovery of Nivasorexant (ACT-539313): The First Selective Orexin‑1 Receptor Antagonist (SO1RA) Investigated in Clinical Trials.
- Author
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Williams, Jodi T., Bolli, Martin H., Brotschi, Christine, Sifferlen, Thierry, Steiner, Michel A., Treiber, Alexander, Gatfield, John, and Boss, Christoph
- Published
- 2024
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30. Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure–activity–relationship, and sleep-promoting properties in rats.
- Author
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Brotschi, Christine, Bolli, Martin H., Gatfield, John, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T., and Boss, Christoph
- Published
- 2024
- Full Text
- View/download PDF
31. Supplementary Table 2 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
- Author
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Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
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32. Supplementary Figure 3 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
- Author
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Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
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33. Supplementary Figure 2 from GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer
- Author
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Nebiker, Christian A., primary, Han, Junyi, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, Hirt, Christian, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Huber, Xaver, primary, Padovan, Elisabetta, primary, Angrisani, Basilio, primary, Droeser, Raoul A., primary, Rosso, Raffaele, primary, Bolli, Martin, primary, Oertli, Daniel, primary, von Holzen, Urs, primary, Adamina, Michel, primary, Muraro, Manuele G., primary, Mengus, Chantal, primary, Zajac, Paul, primary, Sconocchia, Giuseppe, primary, Zuber, Markus, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
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- View/download PDF
34. Supplementary Figure 2 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
- Author
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Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
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- View/download PDF
35. Supplementary Figure 1 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
- Author
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Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
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- View/download PDF
36. Legend from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
- Author
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Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
- Full Text
- View/download PDF
37. Supplementary Table 1 from The Interplay Between Neutrophils and CD8+ T Cells Improves Survival in Human Colorectal Cancer
- Author
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Governa, Valeria, primary, Trella, Emanuele, primary, Mele, Valentina, primary, Tornillo, Luigi, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Muraro, Manuele Giuseppe, primary, Xu, Hui, primary, Droeser, Raoul, primary, Däster, Silvio R., primary, Bolli, Martin, primary, Rosso, Raffaele, primary, Oertli, Daniel, primary, Eppenberger-Castori, Serenella, primary, Terracciano, Luigi M., primary, Iezzi, Giandomenica, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
- Full Text
- View/download PDF
38. Supplementary Figure 1 from GM-CSF Production by Tumor Cells Is Associated with Improved Survival in Colorectal Cancer
- Author
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Nebiker, Christian A., primary, Han, Junyi, primary, Eppenberger-Castori, Serenella, primary, Iezzi, Giandomenica, primary, Hirt, Christian, primary, Amicarella, Francesca, primary, Cremonesi, Eleonora, primary, Huber, Xaver, primary, Padovan, Elisabetta, primary, Angrisani, Basilio, primary, Droeser, Raoul A., primary, Rosso, Raffaele, primary, Bolli, Martin, primary, Oertli, Daniel, primary, von Holzen, Urs, primary, Adamina, Michel, primary, Muraro, Manuele G., primary, Mengus, Chantal, primary, Zajac, Paul, primary, Sconocchia, Giuseppe, primary, Zuber, Markus, primary, Tornillo, Luigi, primary, Terracciano, Luigi, primary, and Spagnoli, Giulio C., primary
- Published
- 2023
- Full Text
- View/download PDF
39. From bosentan (Tracleer®) to macitentan (Opsumit®): The medicinal chemistry perspective
- Author
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Boss, Christoph, Bolli, Martin H., and Gatfield, John
- Published
- 2016
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- View/download PDF
40. Novel S1P1 receptor agonists – Part 4: Alkylaminomethyl substituted aryl head groups
- Author
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Lescop, Cyrille, Müller, Claus, Mathys, Boris, Birker, Magdalena, de Kanter, Ruben, Kohl, Christopher, Hess, Patrick, Nayler, Oliver, Rey, Markus, Sieber, Patrick, Steiner, Beat, Weller, Thomas, and Bolli, Martin H.
- Published
- 2016
- Full Text
- View/download PDF
41. Novel S1P1 receptor agonists – Part 5: From amino-to alkoxy-pyridines
- Author
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Bolli, Martin H., Lescop, Cyrille, Birker, Magdalena, de Kanter, Ruben, Hess, Patrick, Kohl, Christopher, Nayler, Oliver, Rey, Markus, Sieber, Patrick, Velker, Jörg, Weller, Thomas, and Steiner, Beat
- Published
- 2016
- Full Text
- View/download PDF
42. Pyrazole derivatives as selective orexin-2 receptor antagonists (2-SORA): synthesis, structure–activity–relationship, and sleep-promoting properties in ratsElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3md00573a
- Author
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Brotschi, Christine, Bolli, Martin H., Gatfield, John, Roch, Catherine, Sifferlen, Thierry, Treiber, Alexander, Williams, Jodi T., and Boss, Christoph
- Abstract
Selective orexin 2 receptor antagonists (2-SORA) such as seltorexant (15) are in clinical development for the treatment of insomnia and other conditions such as depression. Herein, we report our structure–activity–relationship (SAR) optimization efforts starting from an HTS hit (1) (N-(1-((5-acetylfuran-2-yl)methyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide) that was derived from an unrelated in-house GPCR-agonist program. Medicinal chemistry efforts focused on the optimization of orexin 2 receptor (OX2R) antagonistic activity, stability in liver microsomes, time dependent CYP3A4 inhibition, and aqueous solubility. Compounds were assessed for their brain-penetrating potential in in vivoexperiments to select the most promising compounds for our in vivosleep model. Our lead optimization efforts led to the discovery of the potent, brain penetrating and orally active, 2-SORA (N-(1-(2-(5-methoxy-1H-pyrrolo[3,2-b]pyridin-3-yl)ethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide) 43with efficacy in a sleep model in rats comparable to 15.
- Published
- 2024
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43. Pyrazole derivatives as selective Orexin-2 Receptor Antagonists (2-SORA): Synthesis, Structure-Activity-Relationship, and Sleep-Promoting Properties in Rats
- Author
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Brotschi, Christine, primary, Bolli, Martin Hans, additional, Gatfield, John, additional, Roch, Catherine, additional, Sifferlen, Thierry, additional, Treiber, Alexander, additional, Williams, Jodi T., additional, and Boss, Christoph, additional
- Published
- 2023
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- View/download PDF
44. Magnetic resonance cholangiopancreatography enhanced by virtual reality as a novel tool to improve the understanding of biliary anatomy and the teaching of surgical trainees
- Author
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Staubli, Sebastian M., primary, Maloca, Peter, additional, Kuemmerli, Christoph, additional, Kunz, Julia, additional, Dirnberger, Amanda S., additional, Allemann, Andreas, additional, Gehweiler, Julian, additional, Soysal, Savas, additional, Droeser, Raoul, additional, Däster, Silvio, additional, Hess, Gabriel, additional, Raptis, Dimitri, additional, Kollmar, Otto, additional, von Flüe, Markus, additional, Bolli, Martin, additional, and Cattin, Philippe, additional
- Published
- 2022
- Full Text
- View/download PDF
45. Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells
- Author
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Mele, Valentina; https://orcid.org/0000-0002-7648-0835, Basso, Camilla, Governa, Valeria; https://orcid.org/0000-0001-9999-0590, Glaus Garzon, Jesus F, Muraro, Manuele G; https://orcid.org/0000-0002-4590-1916, Däster, Silvio; https://orcid.org/0000-0001-5188-4908, Nebiker, Christian A, Mechera, Robert; https://orcid.org/0000-0002-4533-9265, Bolli, Martin, Schmidt, Alexander, Geiger, Roger; https://orcid.org/0000-0002-8016-1669, Spagnoli, Giulio C, Christoforidis, Dimitri, Majno, Pietro E, Borsig, Lubor; https://orcid.org/0000-0003-2263-9545, Iezzi, Giandomenica, Mele, Valentina; https://orcid.org/0000-0002-7648-0835, Basso, Camilla, Governa, Valeria; https://orcid.org/0000-0001-9999-0590, Glaus Garzon, Jesus F, Muraro, Manuele G; https://orcid.org/0000-0002-4590-1916, Däster, Silvio; https://orcid.org/0000-0001-5188-4908, Nebiker, Christian A, Mechera, Robert; https://orcid.org/0000-0002-4533-9265, Bolli, Martin, Schmidt, Alexander, Geiger, Roger; https://orcid.org/0000-0002-8016-1669, Spagnoli, Giulio C, Christoforidis, Dimitri, Majno, Pietro E, Borsig, Lubor; https://orcid.org/0000-0003-2263-9545, and Iezzi, Giandomenica
- Abstract
Stromal infiltration is associated with poor prognosis in human colon cancers. However, the high heterogeneity of human tumor-associated stromal cells (TASCs) hampers a clear identification of specific markers of prognostic relevance. To address these issues, we established short-term cultures of TASCs and matched healthy mucosa-associated stromal cells (MASCs) from human primary colon cancers and, upon characterization of their phenotypic and functional profiles in vitro and in vivo, we identified differentially expressed markers by proteomic analysis and evaluated their prognostic significance. TASCs were characterized by higher proliferation and differentiation potential, and enhanced expression of mesenchymal stem cell markers, as compared to MASCs. TASC triggered epithelial-mesenchymal transition (EMT) in tumor cells in vitro and promoted their metastatic spread in vivo, as assessed in an orthotopic mouse model. Proteomic analysis of matched TASCs and MASCs identified a panel of markers preferentially expressed in TASCs. The expression of genes encoding two of them, calponin 1 (CNN1) and tropomyosin beta chain isoform 2 (TPM2), was significantly associated with poor outcome in independent databases and outperformed the prognostic significance of currently proposed TASC markers. The newly identified markers may improve prognostication of primary colon cancers and identification of patients at risk.
- Published
- 2022
46. Identification of TPM2 and CNN1 as Novel Prognostic Markers in Functionally Characterized Human Colon Cancer-Associated Stromal Cells
- Author
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Mele, Valentina, primary, Basso, Camilla, additional, Governa, Valeria, additional, Glaus Garzon, Jesus F., additional, Muraro, Manuele G., additional, Däster, Silvio, additional, Nebiker, Christian A., additional, Mechera, Robert, additional, Bolli, Martin, additional, Schmidt, Alexander, additional, Geiger, Roger, additional, Spagnoli, Giulio C., additional, Christoforidis, Dimitri, additional, Majno, Pietro E., additional, Borsig, Lubor, additional, and Iezzi, Giandomenica, additional
- Published
- 2022
- Full Text
- View/download PDF
47. Standardizing Patient-Derived Organoid Generation Workflow to Avoid Microbial Contamination From Colorectal Cancer Tissues
- Author
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Marinucci, Mattia, primary, Ercan, Caner, additional, Taha-Mehlitz, Stephanie, additional, Fourie, Lana, additional, Panebianco, Federica, additional, Bianco, Gaia, additional, Gallon, John, additional, Staubli, Sebastian, additional, Soysal, Savas D., additional, Zettl, Andreas, additional, Rauthe, Stephan, additional, Vosbeck, Jürg, additional, Droeser, Raoul A., additional, Bolli, Martin, additional, Peterli, Ralph, additional, von Flüe, Markus, additional, Ng, Charlotte K. Y., additional, Kollmar, Otto, additional, Coto-Llerena, Mairene, additional, and Piscuoglio, Salvatore, additional
- Published
- 2022
- Full Text
- View/download PDF
48. Robotic Versus Conventional Minimal-Invasive Inguinal Hernia Repair: Study Protocol for a Prospective, Randomized and Blinded Clinical Trial
- Author
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Angehrn, Fiorenzo V., primary, Neuschütz, Kerstin J., additional, Baur, Johannes, additional, Schneider, Romano, additional, Wilhelm, Alexander, additional, Stoll, Lea, additional, Süsstrunk, Julian, additional, von Flüe, Markus, additional, Bolli, Martin, additional, and Steinemann, Daniel C., additional
- Published
- 2022
- Full Text
- View/download PDF
49. Die Expression von MAGE Tumor assoziierten Antigenen in gut differenzierten, nicht kleinzelligen Lungenkarzinomen korreliert mit geringerem Überleben
- Author
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Bolli, Martin, Kocher, Th., Adamina, M., Spagnoli, G., Sauter, G., Harder, F., Heberer, M., Siewert, J. R., Neugebauer, E., Hartel, W., and Menger, M. D.
- Published
- 2002
- Full Text
- View/download PDF
50. Systematic identification of novel cancer genes through analysis of deep shRNA perturbation screens
- Author
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Montazeri, Hesam, primary, Coto-Llerena, Mairene, additional, Bianco, Gaia, additional, Zangene, Ehsan, additional, Taha-Mehlitz, Stephanie, additional, Paradiso, Viola, additional, Srivatsa, Sumana, additional, de Weck, Antoine, additional, Roma, Guglielmo, additional, Lanzafame, Manuela, additional, Bolli, Martin, additional, Beerenwinkel, Niko, additional, von Flüe, Markus, additional, Terracciano, Luigi M, additional, Piscuoglio, Salvatore, additional, and Ng, Charlotte K Y, additional
- Published
- 2021
- Full Text
- View/download PDF
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