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189 results on '"Breugem, C. C."'

9. Late detection of cleft palate

Author

Hanny, K. H., de Vries, I. A. C., Haverkamp, S. J., Oomen, K. P. Q., Penris, W. M., Eijkemans, M. J. C., Kon, M., Mink van der Molen, A. B., and Breugem, C. C.

Published
2016
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12. Engaging stakeholders in bioprinting research: Views and concerns of microtia patients' parents on bioprinted auricular cartilage

Author

Otto, I A, Simone, A, Malda, J, Kon, M, Breugem, C C, Equine Musculoskeletal Biology, dES RMSC, Equine Musculoskeletal Biology, dES RMSC, Plastic, Reconstructive and Hand Surgery, and Amsterdam Reproduction & Development (AR&D)

Subjects
Male, Parents, Auricular cartilage, medicine.medical_specialty, MEDLINE, Biocompatible Materials, Public engagement, Responsible research and innovation, Chondrocytes, Surveys and Questionnaires, medicine, Humans, Tissue engineering, Child, Congenital Microtia, Medical education, Responsible Research and Innovation, business.industry, Microtia, Bioprinting, medicine.disease, Biocompatible material, Surgery, Printing, Three-Dimensional, Female, business, Stem Cell Transplantation
Published
2020

13. Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities

Author

Otto, I A, Capendale, P E, Garcia, J P, de Ruijter, M, van Doremalen, R F M, Castilho, M, Lawson, T, Grinstaff, M W, Breugem, C C, Kon, M, Levato, R, Malda, J, Otto, I A, Capendale, P E, Garcia, J P, de Ruijter, M, van Doremalen, R F M, Castilho, M, Lawson, T, Grinstaff, M W, Breugem, C C, Kon, M, Levato, R, and Malda, J

Abstract

Bioengineering of the human auricle remains a significant challenge, where the complex and unique shape, the generation of high-quality neocartilage, and shape preservation are key factors. Future regenerative medicine-based approaches for auricular cartilage reconstruction will benefit from a smart combination of various strategies. Our approach to fabrication of an ear-shaped construct uses hybrid bioprinting techniques, a recently identified progenitor cell population, previously validated biomaterials, and a smart scaffold design. Specifically, we generated a 3D-printed polycaprolactone (PCL) scaffold via fused deposition modeling, photocrosslinked a human auricular cartilage progenitor cell-laden gelatin methacryloyl (gelMA) hydrogel within the scaffold, and cultured the bioengineered structure in vitro in chondrogenic media for 30 days. Our results show that the fabrication process maintains the viability and chondrogenic phenotype of the cells, that the compressive properties of the combined PCL and gelMA hybrid auricular constructs are similar to native auricular cartilage, and that biofabricated hybrid auricular structures exhibit excellent shape fidelity compared with the 3D digital model along with deposition of cartilage-like matrix in both peripheral and central areas of the auricular structure. Our strategy affords an anatomically enhanced auricular structure with appropriate mechanical properties, ensures adequate preservation of the auricular shape during a dynamic in vitro culture period, and enables chondrogenically potent progenitor cells to produce abundant cartilage-like matrix throughout the auricular construct. The combination of smart scaffold design with 3D bioprinting and cartilage progenitor cells holds promise for the development of clinically translatable regenerative medicine strategies for auricular reconstruction.

Published
2021

14. Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities

Author

Equine Musculoskeletal Biology, dES RMSC, Otto, I A, Capendale, P E, Garcia, J P, de Ruijter, M, van Doremalen, R F M, Castilho, M, Lawson, T, Grinstaff, M W, Breugem, C C, Kon, M, Levato, R, Malda, J, Equine Musculoskeletal Biology, dES RMSC, Otto, I A, Capendale, P E, Garcia, J P, de Ruijter, M, van Doremalen, R F M, Castilho, M, Lawson, T, Grinstaff, M W, Breugem, C C, Kon, M, Levato, R, and Malda, J

Published
2021

15. Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities

Author

Otto, I. A., Capendale, P. E., Garcia, J. P., de Ruijter, M., van Doremalen, R. F.M., Castilho, M., Lawson, T., Grinstaff, M. W., Breugem, C. C., Kon, M., Levato, R., Malda, J., Otto, I. A., Capendale, P. E., Garcia, J. P., de Ruijter, M., van Doremalen, R. F.M., Castilho, M., Lawson, T., Grinstaff, M. W., Breugem, C. C., Kon, M., Levato, R., and Malda, J.

Abstract

Bioengineering of the human auricle remains a significant challenge, where the complex and unique shape, the generation of high-quality neocartilage, and shape preservation are key factors. Future regenerative medicine–based approaches for auricular cartilage reconstruction will benefit from a smart combination of various strategies. Our approach to fabrication of an ear-shaped construct uses hybrid bioprinting techniques, a recently identified progenitor cell population, previously validated biomaterials, and a smart scaffold design. Specifically, we generated a 3D-printed polycaprolactone (PCL) scaffold via fused deposition modeling, photocrosslinked a human auricular cartilage progenitor cell–laden gelatin methacryloyl (gelMA) hydrogel within the scaffold, and cultured the bioengineered structure in vitro in chondrogenic media for 30 days. Our results show that the fabrication process maintains the viability and chondrogenic phenotype of the cells, that the compressive properties of the combined PCL and gelMA hybrid auricular constructs are similar to native auricular cartilage, and that biofabricated hybrid auricular structures exhibit excellent shape fidelity compared with the 3D digital model along with deposition of cartilage-like matrix in both peripheral and central areas of the auricular structure. Our strategy affords an anatomically enhanced auricular structure with appropriate mechanical properties, ensures adequate preservation of the auricular shape during a dynamic in vitro culture period, and enables chondrogenically potent progenitor cells to produce abundant cartilage-like matrix throughout the auricular construct. The combination of smart scaffold design with 3D bioprinting and cartilage progenitor cells holds promise for the development of clinically translatable regenerative medicine strategies for auricular reconstruction.

Published
2021

16. Microtia and cholesteatoma: Implications for the reconstructive surgeon

Author

Zorgeenheid Plastische Chirurgie Medisch, Zorgeenheid Plastische Chirurgie Zorg, MS KNO, Other research (not in main researchprogram), van Hogezand, R. M., Smit, A. L., Breugem, C. C., Zorgeenheid Plastische Chirurgie Medisch, Zorgeenheid Plastische Chirurgie Zorg, MS KNO, Other research (not in main researchprogram), van Hogezand, R. M., Smit, A. L., and Breugem, C. C.

Published
2021

17. Biofabrication of a shape-stable auricular structure for the reconstruction of ear deformities

Author

Orthopaedie Onderzoek, Zorgeenheid Plastische Chirurgie Zorg, Other research (not in main researchprogram), MS Orthopaedie Algemeen, Zorgeenheid Plastische Chirurgie Medisch, Regenerative Medicine and Stem Cells, Otto, I. A., Capendale, P. E., Garcia, J. P., de Ruijter, M., van Doremalen, R. F.M., Castilho, M., Lawson, T., Grinstaff, M. W., Breugem, C. C., Kon, M., Levato, R., Malda, J., Orthopaedie Onderzoek, Zorgeenheid Plastische Chirurgie Zorg, Other research (not in main researchprogram), MS Orthopaedie Algemeen, Zorgeenheid Plastische Chirurgie Medisch, Regenerative Medicine and Stem Cells, Otto, I. A., Capendale, P. E., Garcia, J. P., de Ruijter, M., van Doremalen, R. F.M., Castilho, M., Lawson, T., Grinstaff, M. W., Breugem, C. C., Kon, M., Levato, R., and Malda, J.

Published
2021

18. Hearing-related quality of life, developmental outcomes and performance in children and young adults with unilateral conductive hearing loss due to aural atresia

Author

MS KNO, Other research (not in main researchprogram), Psychosociale zorg patientenzorg, Brain, Smit, A L, Burgers, Yorick, Swanenburg de Veye, H F N, Stegeman, I, Breugem, C C, MS KNO, Other research (not in main researchprogram), Psychosociale zorg patientenzorg, Brain, Smit, A L, Burgers, Yorick, Swanenburg de Veye, H F N, Stegeman, I, and Breugem, C C

Published
2021

19. Incidence of cleft-related speech problems in children with an isolated cleft lip

Author

Zorgeenheid Plastische Chirurgie Medisch, MS KNO, Smarius, B J A, Haverkamp, S, de Wilde, H, van Wijck-Warnaar, A, Mink van der Molen, A B, Breugem, C C, Zorgeenheid Plastische Chirurgie Medisch, MS KNO, Smarius, B J A, Haverkamp, S, de Wilde, H, van Wijck-Warnaar, A, Mink van der Molen, A B, and Breugem, C C

Published
2021

25. Engaging stakeholders in bioprinting research: Views and concerns of microtia patients’ parents on bioprinted auricular cartilage

Author

Orthopaedie Onderzoek, Zorgeenheid Plastische Chirurgie Zorg, Other research (not in main researchprogram), Regenerative Medicine and Stem Cells, Zorgeenheid Plastische Chirurgie Medisch, Otto, I. A., Simone, A., Malda, J., Kon, M., Breugem, C. C., Orthopaedie Onderzoek, Zorgeenheid Plastische Chirurgie Zorg, Other research (not in main researchprogram), Regenerative Medicine and Stem Cells, Zorgeenheid Plastische Chirurgie Medisch, Otto, I. A., Simone, A., Malda, J., Kon, M., and Breugem, C. C.

Published
2020

29. If it ain't broke don't fix it? Ethics of splinting deformed newborn ears

Author

Zorgeenheid Plastische Chirurgie Zorg, Lab Reumatologie/Klinische Immunologie, Medical Humanities Onderzoek Team 2, Medical Humanities Onderzoek Team 1, Child Health, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Zorgeenheid Plastische Chirurgie Medisch, van Wijk, M. P., Wouters, R. H.P., Bredenoord, A. L., Kon, M., Breugem, C. C., Zorgeenheid Plastische Chirurgie Zorg, Lab Reumatologie/Klinische Immunologie, Medical Humanities Onderzoek Team 2, Medical Humanities Onderzoek Team 1, Child Health, Regenerative Medicine and Stem Cells, JC onderzoeksprogramma Methodologie, Zorgeenheid Plastische Chirurgie Medisch, van Wijk, M. P., Wouters, R. H.P., Bredenoord, A. L., Kon, M., and Breugem, C. C.

Published
2019

35. Abnormal soft palate movements in patients with microtia

Author

Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Kolodzynski, M. N., van Hoorn, B. T.J.A., Kon, M., Breugem, C. C., Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Kolodzynski, M. N., van Hoorn, B. T.J.A., Kon, M., and Breugem, C. C.

Published
2018

36. Impact of unilateral congenital aural atresia on academic Performance: A systematic review

Author

Other research (not in main researchprogram), Zorgeenheid Plastische Chirurgie Medisch, Audiologen, Brain, van Hövell tot Westerflier, C. V.A., van Heteren, J. A.A., Breugem, C. C., Smit, A. L., Stegeman, I., Other research (not in main researchprogram), Zorgeenheid Plastische Chirurgie Medisch, Audiologen, Brain, van Hövell tot Westerflier, C. V.A., van Heteren, J. A.A., Breugem, C. C., Smit, A. L., and Stegeman, I.

Published
2018

37. Internationally adopted children with cleft lip and/or cleft palate: Middle ear findings and hearing during childhood

Author

Zorgeenheid Plastische Chirurgie Medisch, Child Health, Infection & Immunity, MS KNO, Other research (not in main researchprogram), Werker, C. L., van den Aardweg, M. T.A., Coenraad, S., Mink van der Molen, A. B., Breugem, C. C., Zorgeenheid Plastische Chirurgie Medisch, Child Health, Infection & Immunity, MS KNO, Other research (not in main researchprogram), Werker, C. L., van den Aardweg, M. T.A., Coenraad, S., Mink van der Molen, A. B., and Breugem, C. C.

Published
2018

38. Progenitor cells in auricular cartilage demonstrate cartilage-forming capacity in 3D hydrogel culture

Author

Orthopaedie Onderzoek, Other research (not in main researchprogram), Zorgeenheid Plastische Chirurgie Medisch, Regenerative Medicine and Stem Cells, Otto, I A, Levato, R, Webb, W R, Khan, I M, Breugem, C C, Malda, J, Orthopaedie Onderzoek, Other research (not in main researchprogram), Zorgeenheid Plastische Chirurgie Medisch, Regenerative Medicine and Stem Cells, Otto, I A, Levato, R, Webb, W R, Khan, I M, Breugem, C C, and Malda, J

Published
2018

40. Ethical considerations in the translation of regenerative biofabrication technologies into clinic and society

Author

Otto, I A, Breugem, C C, Malda, J, Bredenoord, A L, LS Equine Muscoskeletal Biology, dES RMSC, LS Equine Muscoskeletal Biology, and dES RMSC

Subjects
0301 basic medicine, Societies, Scientific, Engineering, Emerging technologies, Biomedical Engineering, regenerative medicine, translation, Bioengineering, Nanotechnology, Regenerative Medicine, Biochemistry, Article, Personalization, Biomaterials, 03 medical and health sciences, Health care, Journal Article, Animals, Humans, Research ethics, Tissue Engineering, Tissue Scaffolds, business.industry, Scientific progress, Clinical Laboratory Techniques, biofabrication, Novelty, General Medicine, Bioethics, ethics, 3. Good health, 030104 developmental biology, Engineering ethics, business, bioprinting, bioethics, Biotechnology, Biofabrication
Abstract

Biofabrication technologies have the potential to improve healthcare by providing highly advanced and personalized biomedical products for research, treatment and prevention. As the combining of emerging techniques and integrating various biological and synthetic components becomes increasingly complex, it is important that relevant stakeholders anticipate the translation of biofabricated 3D tissue products into patients and society. Ethics is sometimes regarded as a brake on scientific progress, yet from our perspective, ethics in parallel with research anticipates societal impacts of emerging technologies and stimulates responsible innovation. For the ethical assessment, the biofabrication field benefits from similarities to regenerative medicine and an increasing ethical awareness in the development of tissue-engineered products. However, the novelty of the technology itself, the increase in attainable structural complexity, and the potential for automation and personalization are distinguishing facets of biofabrication that call for a specific exploration of the ethics of biofabrication. This review aims to highlight important points of existing ethical discussions, as well as to call attention to emerging issues specific to 3D biofabrication in bench and bedside research and the translation to society.

Published
2016

43. Cost analysis of microtia treatment in the Netherlands

Author

Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Kolodzynski, M. N., van Hövell tot Westerflier, C. V.A., Kon, M., Breugem, C. C., Zorgeenheid Plastische Chirurgie Medisch, Other research (not in main researchprogram), Kolodzynski, M. N., van Hövell tot Westerflier, C. V.A., Kon, M., and Breugem, C. C.

Published
2017

45. Hearing sensitivity in adults with a unilateral cleft lip and palate after two-stage palatoplasty

Author

MS KNO, Poli BT Opl. GNATHO, Zorgeenheid Plastische Chirurgie Zorg, Other research (not in main researchprogram), Kappen, I. F P M, Schreinemakers, J. B S, Oomen, K. P Q, Bittermann, D., Kon, M., Breugem, C. C., Mink van der Molen, A. B., MS KNO, Poli BT Opl. GNATHO, Zorgeenheid Plastische Chirurgie Zorg, Other research (not in main researchprogram), Kappen, I. F P M, Schreinemakers, J. B S, Oomen, K. P Q, Bittermann, D., Kon, M., Breugem, C. C., and Mink van der Molen, A. B.

Published
2017

48. Late detection of cleft palate

Author

Hanny, K H, de Vries, I A C, Haverkamp, S J, Oomen, K P Q, Penris, W M, Eijkemans, M J C, Kon, M, Mink van der Molen, A B, Breugem, C C, Hanny, K H, de Vries, I A C, Haverkamp, S J, Oomen, K P Q, Penris, W M, Eijkemans, M J C, Kon, M, Mink van der Molen, A B, and Breugem, C C

Published
2016

50. Ulcerated infantile haemangiomas: the effect of the selective beta-blocker atenolol on wound healing

Author

Cancer, JC onderzoeksprogramma Kanker, Onderzoek Radiotherapie, MS Dermatologie/Allergologie, Other research (not in main researchprogram), Zorgeenheid Plastische Chirurgie Medisch, Ruitenberg, G, Young-Afat, D A, de Graaf, M, Pasmans, S G M A, Breugem, C C, Cancer, JC onderzoeksprogramma Kanker, Onderzoek Radiotherapie, MS Dermatologie/Allergologie, Other research (not in main researchprogram), Zorgeenheid Plastische Chirurgie Medisch, Ruitenberg, G, Young-Afat, D A, de Graaf, M, Pasmans, S G M A, and Breugem, C C

Published
2016

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