1. The ITGB6 gene: its role in experimental and clinical biology
- Author
-
Amelia Meecham and John Marshall
- Subjects
0301 basic medicine ,Integrins ,Integrin beta Chains ,lcsh:QH426-470 ,Protein subunit ,Integrin ,OSCC, oral squamous cell carcinoma cells ,UTR, Untranslated region ,Article ,Pathogenesis ,03 medical and health sciences ,Mice ,0302 clinical medicine ,Fibrosis ,Antigens, Neoplasm ,Neoplasms ,Genetics ,medicine ,LAP, Latency Associated Peptide ,Animals ,Humans ,skin and connective tissue diseases ,Gene ,Cancer ,chemistry.chemical_classification ,Wound Healing ,biology ,STAT3, signal transducer and activator transcription 3 ,HDAC, Histone deacetylase ,General Medicine ,CREB, cAMP response element ,medicine.disease ,Cell biology ,lcsh:Genetics ,stomatognathic diseases ,030104 developmental biology ,chemistry ,030220 oncology & carcinogenesis ,biology.protein ,HAT, histone acetyltransferase ,Wound healing ,Glycoprotein ,TGFβ1, Transforming growth factor β1 ,Protein Binding - Abstract
Highlights • Expression is restricted to epithelial cells. • Gene knockout promotes increased risk of cancer. • Is associated with fibrosis and multiple cancers. • Mutations in humans have been associated with alopecia, amelogenesis imperfecta, periodontitis and emphysema, matching murine data., Integrin αvβ6 is a membrane-spanning heterodimeric glycoprotein involved in wound healing and the pathogenesis of diseases including fibrosis and cancer. Therefore, it is of great clinical interest for us to understand the molecular mechanisms of its biology. As the limiting binding partner in the heterodimer, the β6 subunit controls αvβ6 expression and availability. Here we describe our understanding of the ITGB6 gene encoding the β6 subunit, including its structure, transcriptional and post-transcriptional regulation, the biological effects observed in ITGB6 deficient mice and clinical cases of ITGB6 mutations.
- Published
- 2019