978 results on '"Calkins, Monica E."'
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2. The General Psychopathology ‘p’ Factor in Adolescence: Multi-Informant Assessment and Computerized Adaptive Testing
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Jones, Jason D., Boyd, Rhonda C., Sandro, Akira Di, Calkins, Monica E., Los Reyes, Andres De, Barzilay, Ran, Young, Jami F., Benton, Tami D., Gur, Ruben C., Moore, Tyler M., and Gur, Raquel E.
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- 2024
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3. Hoarding behavior and its association with mental health and functioning in a large youth sample
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Linkovski, Omer, Moore, Tyler M., Argabright, Stirling T., Calkins, Monica E., Gur, Ruben C., Gur, Raquel E., and Barzilay, Ran
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- 2024
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4. Implementation of an Adapted Fidelity Scale for Pennsylvania Coordinated Specialty Care Programs for First Episode Psychosis
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Jumper, Megan B. E., Friedman, Bess Rose, Becker-Haimes, Emily M., Dong, Fanghong, Kohler, Christian G., Hurford, Irene, and Calkins, Monica E.
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- 2024
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5. Tobacco smoking and nicotine vaping in persons with first episode psychosis
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Bennett, Melanie E., Medoff, Deborah, Cowan, Tovah, Fang, Lijuan, Kacmarek, Corinne, Oikonomou, Maria Theodora, Calkins, Monica E., Baker, Krista K., Bencivengo, Donna, Boumaiz, Yasmine, Buchanan, Robert W., Campbell, Phillip, Chengappa, K.N. Roy, Conroy, Catherine G., Cooke, Akinyi, Dong, Fanghong, Fauble, Mandy, Goldberg, Richard W., Harvin, Alexander, Jumper, Megan B.E., Kauffman, Belinda, Kelly, Christian, Kohler, Christian G., Kreyenbuhl, Julie, Li, Lan, Lucksted, Alicia, Margolis, Russell L., Marsteller, Jill A., Moxam, Alex, Namowicz, Denise, Oko, Jamie, Riggs, Jessie, Saravana, Arunadevi, Sarpal, Deepak K., Scheinberg, Rachel, Smith, William R., States, Richard, Taylor, Jerome, Vatza, Crystal, Wolcott, Max, and Dickerson, Faith
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- 2024
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6. Validation of the structured interview section of the penn computerized adaptive test for neurocognitive and clinical psychopathology assessment (CAT GOASSESS)
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Zoupou, Eirini, Moore, Tyler M., Kennedy, Kelly P., Calkins, Monica E., Gorgone, Alesandra, Sandro, Akira Di, Rush, Sage, Lopez, Katherine C., Ruparel, Kosha, Daryoush, Tarlan, Okoyeh, Paul, Savino, Andrew, Troyan, Scott, Wolf, Daniel H., Scott, J. Cobb, Gur, Raquel E., and Gur, Ruben C.
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- 2024
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7. Mapping genomic loci implicates genes and synaptic biology in schizophrenia
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Trubetskoy, Vassily, Pardiñas, Antonio F, Qi, Ting, Panagiotaropoulou, Georgia, Awasthi, Swapnil, Bigdeli, Tim B, Bryois, Julien, Chen, Chia-Yen, Dennison, Charlotte A, Hall, Lynsey S, Lam, Max, Watanabe, Kyoko, Frei, Oleksandr, Ge, Tian, Harwood, Janet C, Koopmans, Frank, Magnusson, Sigurdur, Richards, Alexander L, Sidorenko, Julia, Wu, Yang, Zeng, Jian, Grove, Jakob, Kim, Minsoo, Li, Zhiqiang, Voloudakis, Georgios, Zhang, Wen, Adams, Mark, Agartz, Ingrid, Atkinson, Elizabeth G, Agerbo, Esben, Al Eissa, Mariam, Albus, Margot, Alexander, Madeline, Alizadeh, Behrooz Z, Alptekin, Köksal, Als, Thomas D, Amin, Farooq, Arolt, Volker, Arrojo, Manuel, Athanasiu, Lavinia, Azevedo, Maria Helena, Bacanu, Silviu A, Bass, Nicholas J, Begemann, Martin, Belliveau, Richard A, Bene, Judit, Benyamin, Beben, Bergen, Sarah E, Blasi, Giuseppe, Bobes, Julio, Bonassi, Stefano, Braun, Alice, Bressan, Rodrigo Affonseca, Bromet, Evelyn J, Bruggeman, Richard, Buckley, Peter F, Buckner, Randy L, Bybjerg-Grauholm, Jonas, Cahn, Wiepke, Cairns, Murray J, Calkins, Monica E, Carr, Vaughan J, Castle, David, Catts, Stanley V, Chambert, Kimberley D, Chan, Raymond CK, Chaumette, Boris, Cheng, Wei, Cheung, Eric FC, Chong, Siow Ann, Cohen, David, Consoli, Angèle, Cordeiro, Quirino, Costas, Javier, Curtis, Charles, Davidson, Michael, Davis, Kenneth L, de Haan, Lieuwe, Degenhardt, Franziska, DeLisi, Lynn E, Demontis, Ditte, Dickerson, Faith, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Duan, Jubao, Ducci, Giuseppe, Dudbridge, Frank, Eriksson, Johan G, Fañanás, Lourdes, Faraone, Stephen V, Fiorentino, Alessia, Forstner, Andreas, Frank, Josef, Freimer, Nelson B, Fromer, Menachem, Frustaci, Alessandra, Gadelha, Ary, Genovese, Giulio, and Gershon, Elliot S
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Brain Disorders ,Human Genome ,Mental Health ,Schizophrenia ,Serious Mental Illness ,Biotechnology ,Neurosciences ,Genetics ,Aetiology ,2.1 Biological and endogenous factors ,Alleles ,Genetic Predisposition to Disease ,Genome-Wide Association Study ,Genomics ,Humans ,Polymorphism ,Single Nucleotide ,Indonesia Schizophrenia Consortium ,PsychENCODE ,Psychosis Endophenotypes International Consortium ,SynGO Consortium ,Schizophrenia Working Group of the Psychiatric Genomics Consortium ,General Science & Technology - Abstract
Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies.
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- 2022
8. Tele-mental Health Transitions for Pennsylvania Coordinated Specialty Care Programs for Early Psychosis During the COVID-19 Pandemic
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Dong, Fanghong, Jumper, Megan B. E., Becker-Haimes, Emily M., Vatza, Crystal, Miao, Lucille(Lucy), Conroy, Catherine, Bennett, Melanie, Sarpal, Deepak K., Abegunde, Courtney, Kohler, Christian G., and Calkins, Monica E.
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- 2023
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9. Validation of the cognitive section of the Penn computerized adaptive test for neurocognitive and clinical psychopathology assessment (CAT-CCNB)
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Di Sandro, Akira, Moore, Tyler M., Zoupou, Eirini, Kennedy, Kelly P., Lopez, Katherine C., Ruparel, Kosha, Njokweni, Lucky J., Rush, Sage, Daryoush, Tarlan, Franco, Olivia, Gorgone, Alesandra, Savino, Andrew, Didier, Paige, Wolf, Daniel H., Calkins, Monica E., Cobb Scott, J., Gur, Raquel E., and Gur, Ruben C.
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- 2024
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10. Inter-rater reliability of subthreshold psychotic symptoms in individuals with 22q11.2 deletion syndrome
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Moore, Tyler M, Salzer, Deby, Bearden, Carrie E, Calkins, Monica E, Kates, Wendy R, Kushan, Leila, Gallagher, Robert Sean, Frumer, Dafna Sofrin, Weinberger, Ronnie, McDonald-McGinn, Donna M, Gur, Raquel E, and Gothelf, Doron
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Biomedical and Clinical Sciences ,Clinical Sciences ,Pediatric ,Clinical Research ,Mental health ,Adolescent ,Adult ,Autism Spectrum Disorder ,Child ,DiGeorge Syndrome ,Female ,Humans ,Male ,Marfan Syndrome ,Psychotic Disorders ,Reproducibility of Results ,Young Adult ,Velocardiofacial syndrome ,DiGeorge ,Subthreshold psychotic symptoms ,Structured Interview for Prodromal Syndromes ,Scale of Prodromal Symptoms ,Inter-rater reliability ,Psychosis risk syndrome ,Neurosciences ,Psychology - Abstract
BackgroundPathways leading to psychosis in 22q11.2 deletion syndrome (22q11.2DS) have been the focus of intensive research during the last two decades. One of the common clinical risk factors for the evolution of psychosis in 22q11.2DS is the presence of positive and negative subthreshold psychotic symptoms. The gold standard for measuring subthreshold symptoms is the Structured Interview for Prodromal Syndromes (SIPS) and its accompanying Scale of Prodromal Symptoms (SOPS) ratings. Although the scale has been used by many centers studying 22q11.2DS, the inter-site reliability of the scale in this population has never been established.MethodsIn the present study, experienced clinical assessors from three large international centers studying 22q11.2DS independently rated video recordings of 18 adolescents and young adults with 22q11.2DS.ResultsThe intraclass correlations coefficients (ICCs) among three raters for the SOPS total scores, as well as for the positive, negative, and disorganization subscale scores, were good-to-excellent (ICCs range 0.73-0.93). The raters were also able to reliably determine the subjects' subthreshold syndrome status (ICC = 0.71). The reliability of individual items was good-to-excellent for all items, ranging from 0.61 for motor disturbances [G3] to 0.95 for bizarre thinking.ConclusionsOur results show that trained clinicians can reliably screen for subthreshold psychotic symptoms in individuals with 22q11.2DS. To increase assessment reliability, we suggest specific clarifications and simplifications to the standard SIPS interview for future studies.
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- 2021
11. Genetic contributors to risk of schizophrenia in the presence of a 22q11.2 deletion.
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Cleynen, Isabelle, Engchuan, Worrawat, Hestand, Matthew S, Heung, Tracy, Holleman, Aaron M, Johnston, H Richard, Monfeuga, Thomas, McDonald-McGinn, Donna M, Gur, Raquel E, Morrow, Bernice E, Swillen, Ann, Vorstman, Jacob AS, Bearden, Carrie E, Chow, Eva WC, van den Bree, Marianne, Emanuel, Beverly S, Vermeesch, Joris R, Warren, Stephen T, Owen, Michael J, Chopra, Pankaj, Cutler, David J, Duncan, Richard, Kotlar, Alex V, Mulle, Jennifer G, Voss, Anna J, Zwick, Michael E, Diacou, Alexander, Golden, Aaron, Guo, Tingwei, Lin, Jhih-Rong, Wang, Tao, Zhang, Zhengdong, Zhao, Yingjie, Marshall, Christian, Merico, Daniele, Jin, Andrea, Lilley, Brenna, Salmons, Harold I, Tran, Oanh, Holmans, Peter, Pardinas, Antonio, Walters, James TR, Demaerel, Wolfram, Boot, Erik, Butcher, Nancy J, Costain, Gregory A, Lowther, Chelsea, Evers, Rens, van Amelsvoort, Therese AMJ, van Duin, Esther, Vingerhoets, Claudia, Breckpot, Jeroen, Devriendt, Koen, Vergaelen, Elfi, Vogels, Annick, Crowley, T Blaine, McGinn, Daniel E, Moss, Edward M, Sharkus, Robert J, Unolt, Marta, Zackai, Elaine H, Calkins, Monica E, Gallagher, Robert S, Gur, Ruben C, Tang, Sunny X, Fritsch, Rosemarie, Ornstein, Claudia, Repetto, Gabriela M, Breetvelt, Elemi, Duijff, Sasja N, Fiksinski, Ania, Moss, Hayley, Niarchou, Maria, Murphy, Kieran C, Prasad, Sarah E, Daly, Eileen M, Gudbrandsen, Maria, Murphy, Clodagh M, Murphy, Declan G, Buzzanca, Antonio, Fabio, Fabio Di, Digilio, Maria C, Pontillo, Maria, Marino, Bruno, Vicari, Stefano, Coleman, Karlene, Cubells, Joseph F, Ousley, Opal Y, Carmel, Miri, Gothelf, Doron, Mekori-Domachevsky, Ehud, Michaelovsky, Elena, Weinberger, Ronnie, Weizman, Abraham, Kushan, Leila, Jalbrzikowski, Maria, Armando, Marco, Eliez, Stéphan, Sandini, Corrado, and Schneider, Maude
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International 22q11.2DS Brain and Behavior Consortium ,Prevention ,Serious Mental Illness ,Genetics ,Human Genome ,Schizophrenia ,Neurosciences ,Mental Health ,Clinical Research ,Pediatric ,Brain Disorders ,2.1 Biological and endogenous factors ,Mental health ,Psychiatry ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences - Abstract
Schizophrenia occurs in about one in four individuals with 22q11.2 deletion syndrome (22q11.2DS). The aim of this International Brain and Behavior 22q11.2DS Consortium (IBBC) study was to identify genetic factors that contribute to schizophrenia, in addition to the ~20-fold increased risk conveyed by the 22q11.2 deletion. Using whole-genome sequencing data from 519 unrelated individuals with 22q11.2DS, we conducted genome-wide comparisons of common and rare variants between those with schizophrenia and those with no psychotic disorder at age ≥25 years. Available microarray data enabled direct comparison of polygenic risk for schizophrenia between 22q11.2DS and independent population samples with no 22q11.2 deletion, with and without schizophrenia (total n = 35,182). Polygenic risk for schizophrenia within 22q11.2DS was significantly greater for those with schizophrenia (padj = 6.73 × 10-6). Novel reciprocal case-control comparisons between the 22q11.2DS and population-based cohorts showed that polygenic risk score was significantly greater in individuals with psychotic illness, regardless of the presence of the 22q11.2 deletion. Within the 22q11.2DS cohort, results of gene-set analyses showed some support for rare variants affecting synaptic genes. No common or rare variants within the 22q11.2 deletion region were significantly associated with schizophrenia. These findings suggest that in addition to the deletion conferring a greatly increased risk to schizophrenia, the risk is higher when the 22q11.2 deletion and common polygenic risk factors that contribute to schizophrenia in the general population are both present.
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- 2021
12. Traumatic stress load and stressor reactivity score associated with accelerated gray matter maturation in youths indexed by normative models
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Wong, Ting Yat, Moore, Tyler M., Seidlitz, Jakob, Yuen, Kenneth S. L., Ruparel, Kosha, Barzilay, Ran, Calkins, Monica E., Alexander-Bloch, Aaron F., Satterthwaite, Theodore D., Gur, Raquel E., and Gur, Ruben C.
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- 2023
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13. Network controllability in transmodal cortex predicts psychosis spectrum symptoms
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Parkes, Linden, Moore, Tyler M., Calkins, Monica E., Cieslak, Matthew, Roalf, David R., Wolf, Daniel H., Gur, Ruben C., Gur, Raquel E., Satterthwaite, Theodore D., and Bassett, Danielle S.
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Quantitative Biology - Neurons and Cognition - Abstract
The psychosis spectrum is associated with structural dysconnectivity concentrated in transmodal association cortex. However, understanding of this pathophysiology has been limited by an exclusive focus on the direct connections to a region. Using Network Control Theory, we measured variation in both direct and indirect structural connections to a region to gain new insights into the pathophysiology of the psychosis spectrum. We used psychosis symptom data and structural connectivity in 1,068 youths aged 8 to 22 years from the Philadelphia Neurodevelopmental Cohort. Applying a Network Control Theory metric called average controllability, we estimated each brain region's capacity to leverage its direct and indirect structural connections to control linear brain dynamics. Next, using non-linear regression, we determined the accuracy with which average controllability could predict negative and positive psychosis spectrum symptoms in out-of-sample testing. We also compared prediction performance for average controllability versus strength, which indexes only direct connections to a region. Finally, we assessed how the prediction performance for psychosis spectrum symptoms varied over the functional hierarchy spanning unimodal to transmodal cortex. Average controllability outperformed strength at predicting positive psychosis spectrum symptoms, demonstrating that indexing indirect structural connections to a region improved prediction performance. Critically, improved prediction was concentrated in association cortex for average controllability, whereas prediction performance for strength was uniform across the cortex, suggesting that indexing indirect connections is crucial in association cortex. Examining inter-individual variation in direct and indirect structural connections to association cortex is crucial for accurate prediction of positive psychosis spectrum symptoms.
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- 2020
14. The Ethics of Risk Prediction for Psychosis and Suicide Attempt in Youth Mental Health
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Smith, William R., Appelbaum, Paul S., Lebowitz, Matthew S., Gülöksüz, Sinan, Calkins, Monica E., Kohler, Christian G., Gur, Raquel E., and Barzilay, Ran
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- 2023
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15. Evaluation of a new intrinsic and extrinsic motivation scale in youth with psychosis spectrum symptoms
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Didier, Paige R., Moore, Tyler M., Calkins, Monica E., Prettyman, Greer, Levinson, Tess, Savage, Chloe, de Moraes Leme, Luis Fernando Viegas, Kohler, Christian G., Kable, Joseph, Satterthwaite, Theodore, Gur, Ruben C., Gur, Raquel E., and Wolf, Daniel H.
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- 2023
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16. Individual differences in delay discounting are associated with dorsal prefrontal cortex connectivity in children, adolescents, and adults
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Mehta, Kahini, Pines, Adam, Adebimpe, Azeez, Larsen, Bart, Bassett, Danielle S., Calkins, Monica E., Baller, Erica B., Gell, Martin, Patrick, Lauren M., Shafiei, Golia, Gur, Raquel E., Gur, Ruben C., Roalf, David R., Romer, Daniel, Wolf, Daniel H., Kable, Joseph W., and Satterthwaite, Theodore D.
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- 2023
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17. Counterpoint. Early intervention for psychosis risk syndromes: Minimizing risk and maximizing benefit.
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Woods, Scott W, Bearden, Carrie E, Sabb, Fred W, Stone, William S, Torous, John, Cornblatt, Barbara A, Perkins, Diana O, Cadenhead, Kristin S, Addington, Jean, Powers, Albert R, Mathalon, Daniel H, Calkins, Monica E, Wolf, Daniel H, Corcoran, Cheryl M, Horton, Leslie E, Mittal, Vijay A, Schiffman, Jason, Ellman, Lauren M, Strauss, Gregory P, Mamah, Daniel, Choi, Jimmy, Pearlson, Godfrey D, Shah, Jai L, Fusar-Poli, Paolo, Arango, Celso, Perez, Jesus, Koutsouleris, Nikolaos, Wang, Jijun, Kwon, Jun Soo, Walsh, Barbara C, McGlashan, Thomas H, Hyman, Steven E, Gur, Raquel E, Cannon, Tyrone D, Kane, John M, and Anticevic, Alan
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Humans ,Syndrome ,Psychotic Disorders ,Social Stigma ,Autonomy ,Beneficence ,Biomarkers ,Clinical high risk ,Psychosis ,Stigma ,Clinical Research ,Mental Health ,Serious Mental Illness ,Pediatric Research Initiative ,Prevention ,Good Health and Well Being ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
BackgroundMalhi et al. in this issue critique the clinical high risk (CHR) syndrome for psychosis.MethodResponse to points of critique.ResultsWe agree that inconsistency in CHR nomenclature should be minimized. We respectfully disagree on other points. In our view: a) individuals with CHR and their families need help, using existing interventions, even though we do not yet fully understand disease mechanisms; b) substantial progress has been made in identification of biomarkers; c) symptoms used to identify CHR are specific to psychotic illnesses; d) CHR diagnosis is not "extremely difficult"; e) the pattern of progression, although heterogenous, is discernible; f) "psychosis-like symptoms" are common but are not used to identify CHR; and g) on the point described as 'the real risk,' CHR diagnosis does not frequently cause harmful stigma.DiscussionMalhi et al.'s arguments do not fairly characterize progress in the CHR field nor efforts to minimize stigma. That said, much work remains in areas of consistent nomenclature, mechanisms of disease, dissecting heterogeneity, and biomarkers. With regard to what the authors term the "real risk" of stigma associated with a CHR "label," however, our view is that avoiding words like "risk" and "psychosis" reinforces the stigma that both they and we mean to oppose. Moreover, patients and their families benefit from being given a term that describes what is happening to them.
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- 2021
18. Development of Iron Status Measures during Youth: Associations with Sex, Neighborhood Socioeconomic Status, Cognitive Performance, and Brain Structure
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Larsen, Bart, Baller, Erica B, Boucher, Alexander A, Calkins, Monica E, Laney, Nina, Moore, Tyler M, Roalf, David R, Ruparel, Kosha, Gur, Ruben C, Gur, Raquel E, Georgieff, Michael K, and Satterthwaite, Theodore D
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- 2023
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19. Illness Phase as a Key Assessment and Intervention Window for Psychosis
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D'Souza, Deepak, Srihari, Vinod, Gueorguieva, Ralitza, Patel, Prashant, Forselius-Bielen, Kimberlee, Lu, Jing, Butler, Audrey, Fram, Geena, Afriyie-Agyemang, Yvette, Selloni, Alexandria, Cadavid, Laura, Gomez-Luna, Sandra, Gupta, Aarti, Radhakrishnan, Rajiv, Rashid, Ali, Aker, Ryan, Abrahim, Philisha, Nia, Anahita Bassir, Surti, Toral, Kegeles, Lawrence S., Carlson, Marlene, Goldberg, Terry, Gangwisch, James, Benedict, Erinne, Govil, Preetika, Brazis, Stephanie, Mayer, Megan, Garrigue, Nathalie de la, Fallon, Natalka, Baumvoll, Topaz, Abeykoon, Sameera, Perlman, Greg, Bobchin, Kelly, Elliott, Mark, Schmidt, Lyndsay, Rush, Sage, Port, Allison, Heffernan, Zac, Laney, Nina, Kantor, Jenna, Hohing, Thomas, Kohler, Christian G., Wolf, Daniel H., Abi-Dargham, Anissa, Anticevic, Alan, Cho, Youngsun T., Fonteneau, Clara, Gil, Roberto, Girgis, Ragy R., Gray, David L., Grinband, Jack, Javitch, Jonathan A., Kantrowitz, Joshua T., Krystal, John H., Lieberman, Jeffrey A., Murray, John D., Ranganathan, Mohini, Santamauro, Nicole, Van Snellenberg, Jared X., Tamayo, Zailyn, Gur, Ruben C., Gur, Raquel E., and Calkins, Monica E.
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- 2023
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20. Activation of Internal Correctness Monitoring Circuitry in Youths With Psychosis Spectrum Symptoms
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Levinson, Tess, Prettyman, Greer, Savage, Chloe, White, Lauren, Moore, Tyler M., Calkins, Monica E., Ruparel, Kosha, Gur, Raquel E., Gur, Ruben C., Satterthwaite, Theodore D., and Wolf, Daniel H.
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- 2023
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21. Heritability of acoustic startle magnitude and latency from the consortium on the genetics of schizophrenia
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Greenwood, Tiffany A, Swerdlow, Neal R, Sprock, Joyce, Calkins, Monica E, Freedman, Robert, Green, Michael F, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Light, Gregory A, Nuechterlein, Keith H, Radant, Allen D, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Braff, David L, and Duncan, Erica
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Neurosciences ,Clinical Research ,Schizophrenia ,Brain Disorders ,Genetics ,Mental Health ,Acoustic Stimulation ,Acoustics ,Humans ,Prepulse Inhibition ,Reflex ,Startle ,Latency ,Heritability ,Acoustic startle ,Endophenotype ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
BackgroundLatency of the acoustic startle reflex is the time from presentation of the startling stimulus until the response, and provides an index of neural processing speed. Schizophrenia subjects exhibit slowed latency compared to healthy controls. One prior publication reported significant heritability of latency. The current study was undertaken to replicate and extend this solitary finding in a larger cohort.MethodsSchizophrenia probands, their relatives, and control subjects from the Consortium on the Genetics of Schizophrenia (COGS-1) were tested in a paradigm to ascertain magnitude, latency, and prepulse inhibition of startle. Trial types in the paradigm were: pulse-alone, and trials with 30, 60, or 120 ms between the prepulse and pulse. Comparisons of subject groups were conducted with ANCOVAs to assess startle latency and magnitude. Heritability of startle magnitude and latency was analyzed with a variance component method implemented in SOLAR v.4.3.1.Results980 subjects had analyzable startle results: 199 schizophrenia probands, 456 of their relatives, and 325 controls. A mixed-design ANCOVA on startle latency in the four trial types was significant for subject group (F(2,973) = 4.45, p = 0.012) such that probands were slowest, relatives were intermediate and controls were fastest. Magnitude to pulse-alone trials differed significantly between groups by ANCOVA (F(2,974) = 3.92, p = 0.020) such that controls were lowest, probands highest, and relatives intermediate. Heritability was significant (p
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- 2020
22. Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study
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Greenwood, Tiffany A, Lazzeroni, Laura C, Maihofer, Adam X, Swerdlow, Neal R, Calkins, Monica E, Freedman, Robert, Green, Michael F, Light, Gregory A, Nievergelt, Caroline M, Nuechterlein, Keith H, Radant, Allen D, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Gur, Ruben C, Gur, Raquel E, and Braff, David L
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Schizophrenia ,Neurosciences ,Human Genome ,Genetics ,Mental Health ,Clinical Research ,Brain Disorders ,2.1 Biological and endogenous factors ,Aetiology ,Mental health ,Good Health and Well Being ,Adult ,Cognitive Dysfunction ,Endophenotypes ,Female ,Genome-Wide Association Study ,Humans ,Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels ,Male ,Middle Aged ,Neuregulins ,Potassium Channels ,Other Medical and Health Sciences ,Psychology ,Cognitive Sciences - Abstract
ImportanceThe Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in schizophrenia as a platform from which to explore the underlying neural circuitry and genetic architecture. Many of these endophenotypes are associated with poor functional outcome in schizophrenia. Some are also endorsed as potential treatment targets by the US Food and Drug Administration.ObjectiveTo build on prior assessments of heritability, association, and linkage in the COGS phase 1 (COGS-1) families by reporting a genome-wide association study (GWAS) of 11 schizophrenia-related endophenotypes in the independent phase 2 (COGS-2) cohort of patients with schizophrenia and healthy comparison participants (HCPs).Design, setting, and participantsA total of 1789 patients with schizophrenia and HCPs of self-reported European or Latino ancestry were recruited through a collaborative effort across the COGS sites and genotyped using the PsychChip. Standard quality control filters were applied, and more than 6.2 million variants with a genotyping call rate of greater than 0.99 were available after imputation. Association was performed for data sets stratified by diagnosis and ancestry using linear regression and adjusting for age, sex, and 5 principal components, with results combined through weighted meta-analysis. Data for COGS-1 were collected from January 6, 2003, to August 6, 2008; data for COGS-2, from June 30, 2010, to February 14, 2014. Data were analyzed from October 28, 2016, to May 4, 2018.Main outcomes and measuresA genome-wide association study was performed to evaluate association for 11 neurophysiological and neurocognitive endophenotypes targeting key domains of schizophrenia related to inhibition, attention, vigilance, learning, working memory, executive function, episodic memory, and social cognition.ResultsThe final sample of 1533 participants included 861 male participants (56.2%), and the mean (SD) age was 41.8 (13.6) years. In total, 7 genome-wide significant regions (P
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- 2019
23. Construction of a computerized adaptive test (CAT-CCNB) for efficient neurocognitive and clinical psychopathology assessment
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Moore, Tyler M., Di Sandro, Akira, Scott, J. Cobb, Lopez, Katherine C., Ruparel, Kosha, Njokweni, Lucky J., Santra, Satrajit, Conway, David S., Port, Allison M., D’Errico, Lisa, Rush, Sage, Wolf, Daniel H., Calkins, Monica E., Gur, Raquel E., and Gur, Ruben C.
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- 2023
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24. Mobile footprinting: linking individual distinctiveness in mobility patterns to mood, sleep, and brain functional connectivity
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Xia, Cedric Huchuan, Barnett, Ian, Tapera, Tinashe M., Adebimpe, Azeez, Baker, Justin T., Bassett, Danielle S., Brotman, Melissa A., Calkins, Monica E., Cui, Zaixu, Leibenluft, Ellen, Linguiti, Sophia, Lydon-Staley, David M., Martin, Melissa Lynne, Moore, Tyler M., Murtha, Kristin, Piiwaa, Kayla, Pines, Adam, Roalf, David R., Rush-Goebel, Sage, Wolf, Daniel H., Ungar, Lyle H., and Satterthwaite, Theodore D.
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- 2022
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25. A Developmental Perspective on Early and Current Motor Abnormalities and Psychotic-Like Symptoms
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Fattal, Jessica, primary, Giljen, Maksim, additional, Vargas, Teresa, additional, Damme, Katherine S F, additional, Calkins, Monica E, additional, Pinkham, Amy E, additional, and Mittal, Vijay A, additional
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- 2024
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26. 338. Mediation of Family History Association With Adolescent Behavioral Health by Reported Trauma Exposures
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Chaiyachati, Barbara, primary, Catalano, Jamie L., additional, Schultz, Laura M., additional, Almasy, Laura, additional, Visoki, Elina, additional, Seidlitz, Jakob, additional, Moore, Tyler M., additional, Taylor, Jerome, additional, Calkins, Monica E., additional, Gur, Raquel E., additional, and Barzilay, Ran, additional
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- 2024
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27. Linking Individual Differences in Personalized Functional Network Topography to Psychopathology in Youth
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Cui, Zaixu, Pines, Adam R., Larsen, Bart, Sydnor, Valerie J., Li, Hongming, Adebimpe, Azeez, Alexander-Bloch, Aaron F., Bassett, Dani S., Bertolero, Max, Calkins, Monica E., Davatzikos, Christos, Fair, Damien A., Gur, Ruben C., Gur, Raquel E., Moore, Tyler M., Shanmugan, Sheila, Shinohara, Russell T., Vogel, Jacob W., Xia, Cedric H., Fan, Yong, and Satterthwaite, Theodore D.
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- 2022
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28. Connectome-wide Functional Connectivity Abnormalities in Youth With Obsessive-Compulsive Symptoms
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Alexander-Bloch, Aaron F., Sood, Rahul, Shinohara, Russell T., Moore, Tyler M., Calkins, Monica E., Chertavian, Casey, Wolf, Daniel H., Gur, Ruben C., Satterthwaite, Theodore D., Gur, Raquel E., and Barzilay, Ran
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- 2022
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29. Ethical considerations for precision psychiatry: A roadmap for research and clinical practice
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Fusar-Poli, Paolo, Manchia, Mirko, Koutsouleris, Nikolaos, Leslie, David, Woopen, Christiane, Calkins, Monica E., Dunn, Michael, Tourneau, Christophe Le, Mannikko, Miia, Mollema, Tineke, Oliver, Dominic, Rietschel, Marcella, Reininghaus, Eva Z., Squassina, Alessio, Valmaggia, Lucia, Kessing, Lars Vedel, Vieta, Eduard, Correll, Christoph U., Arango, Celso, and Andreassen, Ole A.
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- 2022
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30. Comparison of two cognitive screening measures in a longitudinal sample of youth at-risk for psychosis
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Kantor, Jenna R., Gur, Ruben C., Calkins, Monica E., Moore, Tyler M., Port, Allison M., Ruparel, Kosha, Scott, J. Cobb, Troyan, Scott, Gur, Raquel E., and Roalf, David R.
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- 2022
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31. Risk and Resilience Measures Related to Psychopathology in Youth
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White, Lauren K., Barzilay, Ran, Moore, Tyler M., Calkins, Monica E., Jones, Jason D., Himes, Megan M., Young, Jami F., Gur, Ruben C., and Gur, Raquel E.
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- 2022
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32. Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension.
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Swerdlow, Neal R, Light, Gregory A, Thomas, Michael L, Sprock, Joyce, Calkins, Monica E, Green, Michael F, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Radant, Allen D, Seidman, Larry J, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, and Braff, David L
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Humans ,Gait Disorders ,Neurologic ,Antipsychotic Agents ,Acoustic Stimulation ,Analysis of Variance ,Cohort Studies ,Schizophrenia ,Psychiatric Status Rating Scales ,Neural Inhibition ,Adolescent ,Adult ,Middle Aged ,Female ,Male ,Young Adult ,Endophenotypes ,Prepulse Inhibition ,Endophenotype ,Prepulse inhibition ,Replication ,Startle ,Clinical Research ,Mental Health ,Brain Disorders ,Aetiology ,2.1 Biological and endogenous factors ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
BackgroundThe Consortium on the Genetics of Schizophrenia (COGS) collected case-control endophenotype and genetic information from 2457 patients and healthy subjects (HS) across 5 test sites over 3.5 years. Analysis of the first "wave" (W1) of 1400 subjects identified prepulse inhibition (PPI) deficits in patients vs. HS. Data from the second COGS "wave" (W2), and the combined W(1+2), were used to assess: 1) the replicability of PPI deficits in this design; 2) the impact of response criteria on PPI deficits; and 3) PPI in a large cohort of antipsychotic-free patients.MethodsPPI in W2 HS (n=315) and schizophrenia patients (n=326) was compared to findings from W1; planned analyses assessed the impact of diagnosis, "wave" (1 vs. 2), and startle magnitude criteria. Combining waves allowed us to assess PPI in 120 antipsychotic-free patients, including many in the early course of illness.ResultsANOVA of all W(1+2) subjects revealed robust PPI deficits in patients across "waves" (p
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- 2018
33. Reasons for Discharge in a National Network of Early Psychosis Intervention Programs
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Phalen, Peter, primary, Smith, William R., additional, Jones, Nev, additional, Reznik, Samantha J, additional, Marti, C. Nathan, additional, Cosgrove, John, additional, Lopez, Molly, additional, Calkins, Monica E., additional, and Bennett, Melanie, additional
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- 2024
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34. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ): Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
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Wannan, Cassandra M J, primary, Nelson, Barnaby, additional, Addington, Jean, additional, Allott, Kelly, additional, Anticevic, Alan, additional, Arango, Celso, additional, Baker, Justin T, additional, Bearden, Carrie E, additional, Billah, Tashrif, additional, Bouix, Sylvain, additional, Broome, Matthew R, additional, Buccilli, Kate, additional, Cadenhead, Kristin S, additional, Calkins, Monica E, additional, Cannon, Tyrone D, additional, Cecci, Guillermo, additional, Chen, Eric Yu Hai, additional, Cho, Kang Ik K, additional, Choi, Jimmy, additional, Clark, Scott R, additional, Coleman, Michael J, additional, Conus, Philippe, additional, Corcoran, Cheryl M, additional, Cornblatt, Barbara A, additional, Diaz-Caneja, Covadonga M, additional, Dwyer, Dominic, additional, Ebdrup, Bjørn H, additional, Ellman, Lauren M, additional, Fusar-Poli, Paolo, additional, Galindo, Liliana, additional, Gaspar, Pablo A, additional, Gerber, Carla, additional, Glenthøj, Louise Birkedal, additional, Glynn, Robert, additional, Harms, Michael P, additional, Horton, Leslie E, additional, Kahn, René S, additional, Kambeitz, Joseph, additional, Kambeitz-Ilankovic, Lana, additional, Kane, John M, additional, Kapur, Tina, additional, Keshavan, Matcheri S, additional, Kim, Sung-Wan, additional, Koutsouleris, Nikolaos, additional, Kubicki, Marek, additional, Kwon, Jun Soo, additional, Langbein, Kerstin, additional, Lewandowski, Kathryn E, additional, Light, Gregory A, additional, Mamah, Daniel, additional, Marcy, Patricia J, additional, Mathalon, Daniel H, additional, McGorry, Patrick D, additional, Mittal, Vijay A, additional, Nordentoft, Merete, additional, Nunez, Angela, additional, Pasternak, Ofer, additional, Pearlson, Godfrey D, additional, Perez, Jesus, additional, Perkins, Diana O, additional, Powers, Albert R, additional, Roalf, David R, additional, Sabb, Fred W, additional, Schiffman, Jason, additional, Shah, Jai L, additional, Smesny, Stefan, additional, Spark, Jessica, additional, Stone, William S, additional, Strauss, Gregory P, additional, Tamayo, Zailyn, additional, Torous, John, additional, Upthegrove, Rachel, additional, Vangel, Mark, additional, Verma, Swapna, additional, Wang, Jijun, additional, Rossum, Inge Winter-van, additional, Wolf, Daniel H, additional, Wolff, Phillip, additional, Wood, Stephen J, additional, Yung, Alison R, additional, Agurto, Carla, additional, Alvarez-Jimenez, Mario, additional, Amminger, Paul, additional, Armando, Marco, additional, Asgari-Targhi, Ameneh, additional, Cahill, John, additional, Carrión, Ricardo E, additional, Castro, Eduardo, additional, Cetin-Karayumak, Suheyla, additional, Mallar Chakravarty, M, additional, Cho, Youngsun T, additional, Cotter, David, additional, D’Alfonso, Simon, additional, Ennis, Michaela, additional, Fadnavis, Shreyas, additional, Fonteneau, Clara, additional, Gao, Caroline, additional, Gupta, Tina, additional, Gur, Raquel E, additional, Gur, Ruben C, additional, Hamilton, Holly K, additional, Hoftman, Gil D, additional, Jacobs, Grace R, additional, Jarcho, Johanna, additional, Ji, Jie Lisa, additional, Kohler, Christian G, additional, Lalousis, Paris Alexandros, additional, Lavoie, Suzie, additional, Lepage, Martin, additional, Liebenthal, Einat, additional, Mervis, Josh, additional, Murty, Vishnu, additional, Nicholas, Spero C, additional, Ning, Lipeng, additional, Penzel, Nora, additional, Poldrack, Russell, additional, Polosecki, Pablo, additional, Pratt, Danielle N, additional, Rabin, Rachel, additional, Rahimi Eichi, Habiballah, additional, Rathi, Yogesh, additional, Reichenberg, Avraham, additional, Reinen, Jenna, additional, Rogers, Jack, additional, Ruiz-Yu, Bernalyn, additional, Scott, Isabelle, additional, Seitz-Holland, Johanna, additional, Srihari, Vinod H, additional, Srivastava, Agrima, additional, Thompson, Andrew, additional, Turetsky, Bruce I, additional, Walsh, Barbara C, additional, Whitford, Thomas, additional, Wigman, Johanna T W, additional, Yao, Beier, additional, Yuen, Hok Pan, additional, Ahmed, Uzair, additional, Byun, Andrew (Jin Soo), additional, Chung, Yoonho, additional, Do, Kim, additional, Hendricks, Larry, additional, Huynh, Kevin, additional, Jeffries, Clark, additional, Lane, Erlend, additional, Langholm, Carsten, additional, Lin, Eric, additional, Mantua, Valentina, additional, Santorelli, Gennarina, additional, Ruparel, Kosha, additional, Zoupou, Eirini, additional, Adasme, Tatiana, additional, Addamo, Lauren, additional, Adery, Laura, additional, Ali, Munaza, additional, Auther, Andrea, additional, Aversa, Samantha, additional, Baek, Seon-Hwa, additional, Bates, Kelly, additional, Bathery, Alyssa, additional, Bayer, Johanna M M, additional, Beedham, Rebecca, additional, Bilgrami, Zarina, additional, Birch, Sonia, additional, Bonoldi, Ilaria, additional, Borders, Owen, additional, Borgatti, Renato, additional, Brown, Lisa, additional, Bruna, Alejandro, additional, Carrington, Holly, additional, Castillo-Passi, Rolando I, additional, Chen, Justine, additional, Cheng, Nicholas, additional, Ching, Ann Ee, additional, Clifford, Chloe, additional, Colton, Beau-Luke, additional, Contreras, Pamela, additional, Corral, Sebastián, additional, Damiani, Stefano, additional, Done, Monica, additional, Estradé, Andrés, additional, Etuka, Brandon Asika, additional, Formica, Melanie, additional, Furlan, Rachel, additional, Geljic, Mia, additional, Germano, Carmela, additional, Getachew, Ruth, additional, Goncalves, Mathias, additional, Haidar, Anastasia, additional, Hartmann, Jessica, additional, Jo, Anna, additional, John, Omar, additional, Kerins, Sarah, additional, Kerr, Melissa, additional, Kesselring, Irena, additional, Kim, Honey, additional, Kim, Nicholas, additional, Kinney, Kyle, additional, Krcmar, Marija, additional, Kotler, Elana, additional, Lafanechere, Melanie, additional, Lee, Clarice, additional, Llerena, Joshua, additional, Markiewicz, Christopher, additional, Matnejl, Priya, additional, Maturana, Alejandro, additional, Mavambu, Aissata, additional, Mayol-Troncoso, Rocío, additional, McDonnell, Amelia, additional, McGowan, Alessia, additional, McLaughlin, Danielle, additional, McIlhenny, Rebecca, additional, McQueen, Brittany, additional, Mebrahtu, Yohannes, additional, Mensi, Martina, additional, Hui, Christy Lai Ming, additional, Suen, Yi Nam, additional, Wong, Stephanie Ming Yin, additional, Morrell, Neal, additional, Omar, Mariam, additional, Partridge, Alice, additional, Phassouliotis, Christina, additional, Pichiecchio, Anna, additional, Politi, Pierluigi, additional, Porter, Christian, additional, Provenzani, Umberto, additional, Prunier, Nicholas, additional, Raj, Jasmine, additional, Ray, Susan, additional, Rayner, Victoria, additional, Reyes, Manuel, additional, Reynolds, Kate, additional, Rush, Sage, additional, Salinas, Cesar, additional, Shetty, Jashmina, additional, Snowball, Callum, additional, Tod, Sophie, additional, Turra-Fariña, Gabriel, additional, Valle, Daniela, additional, Veale, Simone, additional, Whitson, Sarah, additional, Wickham, Alana, additional, Youn, Sarah, additional, Zamorano, Francisco, additional, Zavaglia, Elissa, additional, Zinberg, Jamie, additional, Woods, Scott W, additional, and Shenton, Martha E, additional
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- 2024
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35. Multimorbidity networks of mental disorder symptom domains across psychopathology severity levels in community youth
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Imperiale, Marina N., Lieb, Roselind, Calkins, Monica E., and Meinlschmidt, Gunther
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- 2021
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36. Association between traumatic stressful events and schizotypal symptoms among a community-based sample of adolescents: A 2-year longitudinal study
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Dong, Fanghong, Calkins, Monica E., Compton, Peggy, Medoff-Cooper, Barbara, Barzilay, Ran, Taylor, Jerome H., Moore, Tyler M., Gur, Ruben C., Gur, Raquel E., and Hodgson, Nancy A.
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- 2021
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37. Subthreshold Psychosis in 22q11.2 Deletion Syndrome: Multisite Naturalistic Study.
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Weisman, Omri, Guri, Yael, Gur, Raquel E, McDonald-McGinn, Donna M, Calkins, Monica E, Tang, Sunny X, Emanuel, Beverly, Zackai, Elaine H, Eliez, Stephan, Schneider, Maude, Schaer, Marie, Kates, Wendy R, Antshel, Kevin M, Fremont, Wanda, Shashi, Vandana, Hooper, Stephen R, Armando, Marco, Vicari, Stefano, Pontillo, Maria, Kushan, Leila, Jalbrzikowski, Maria, Bearden, Carrie E, Cubells, Joseph F, Ousley, Opal Y, Walker, Elaine F, Simon, Tony J, Stoddard, Joel, Niendam, Tara A, van den Bree, Marianne BM, and Gothelf, Doron
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Biomedical and Clinical Sciences ,Clinical Sciences ,Behavioral and Social Science ,Mental Health ,Serious Mental Illness ,Brain Disorders ,Neurosciences ,Clinical Research ,Pediatric ,Clinical Trials and Supportive Activities ,Mental health ,Adolescent ,Adult ,Anxiety Disorders ,Attention Deficit Disorder with Hyperactivity ,Child ,Cognitive Dysfunction ,Comorbidity ,DiGeorge Syndrome ,Humans ,Middle Aged ,Prodromal Symptoms ,Psychotic Disorders ,Young Adult ,velocardiofacial syndrome ,subthreshold psychotic symptoms ,structured interview for prodromal syndromes ,anxiety disorder ,global assessment of functioning ,attention deficit ,hyperactivity disorder ,IQ ,DiGeorge syndrome ,International Consortium on Brain and Behavior in 22q11.2 Deletion Syndrome ,attention deficit/hyperactivity disorder ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences - Abstract
Nearly one-third of individuals with 22q11.2 deletion syndrome (22q11.2DS) develop a psychotic disorder during life, most of them by early adulthood. Importantly, a full-blown psychotic episode is usually preceded by subthreshold symptoms. In the current study, 760 participants (aged 6-55 years) with a confirmed hemizygous 22q11.2 microdeletion have been recruited through 10 medical sites worldwide, as part of an international research consortium. Of them, 692 were nonpsychotic and with complete measurement data. Subthreshold psychotic symptoms were assessed using the Structured Interview for Prodromal Syndromes (SIPS). Nearly one-third of participants met criteria for positive subthreshold psychotic symptoms (32.8%), less than 1% qualified for acute positive subthreshold symptoms, and almost a quarter met criteria for negative/disorganized subthreshold symptoms (21.7%). Adolescents and young adults (13-25 years) showed the highest rates of subthreshold psychotic symptoms. Additionally, higher rates of anxiety disorders and attention deficit/hyperactivity disorder (ADHD) were found among the study participants with subthreshold psychotic symptoms compared to those without. Full-scale IQ, verbal IQ, and global functioning (GAF) scores were negatively associated with participants' subthreshold psychotic symptoms. This study represents the most comprehensive analysis reported to date on subthreshold psychosis in 22q11.2DS. Novel findings include age-related changes in subthreshold psychotic symptoms and evidence that cognitive deficits are associated with subthreshold psychosis in this population. Future studies should longitudinally follow these symptoms to detect whether and how early identification and treatment of these manifestations can improve long-term outcomes in those that eventually develop a psychotic disorder.
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- 2017
38. Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia.
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Thomas, Michael L, Green, Michael F, Hellemann, Gerhard, Sugar, Catherine A, Tarasenko, Melissa, Calkins, Monica E, Greenwood, Tiffany A, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Radant, Allen D, Seidman, Larry J, Shiluk, Alexandra L, Siever, Larry J, Silverman, Jeremy M, Sprock, Joyce, Stone, William S, Swerdlow, Neal R, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Braff, David L, and Light, Gregory A
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Humans ,Auditory Perceptual Disorders ,Disability Evaluation ,Cross-Sectional Studies ,Cognition Disorders ,Psychotic Disorders ,Schizophrenia ,Psychiatric Status Rating Scales ,Schizophrenic Psychology ,Contingent Negative Variation ,Models ,Psychological ,Social Behavior Disorders ,Adult ,Middle Aged ,Female ,Male ,Mental Health ,Clinical Research ,Behavioral and Social Science ,Serious Mental Illness ,Prevention ,Brain Disorders ,Neurosciences ,Mental health ,Other Medical and Health Sciences ,Psychology ,Cognitive Sciences - Abstract
ImportanceNeurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention studies. Research in schizophrenia has established correlations among measures of EAP, cognition, clinical symptoms, and functional outcome. Clarifying these associations by determining the pathways through which deficits in EAP affect functioning would suggest when and where to therapeutically intervene.ObjectivesTo characterize the pathways from EAP to outcome and to estimate the extent to which enhancement of basic information processing might improve cognition and psychosocial functioning in schizophrenia.Design, setting, and participantsCross-sectional data were analyzed using structural equation modeling to examine the associations among EAP, cognition, negative symptoms, and functional outcome. Participants were recruited from the community at 5 geographically distributed laboratories as part of the Consortium on the Genetics of Schizophrenia 2 from July 1, 2010, through January 31, 2014. This well-characterized cohort of 1415 patients with schizophrenia underwent EAP, cognitive, and thorough clinical and functional assessment.Main outcome and measuresMismatch negativity, P3a, and reorienting negativity were used to measure EAP. Cognition was measured by the Letter Number Span test and scales from the California Verbal Learning Test-Second Edition, the Wechsler Memory Scale-Third Edition, and the Penn Computerized Neurocognitive Battery. Negative symptoms were measured by the Scale for the Assessment of Negative Symptoms. Functional outcome was measured by the Role Functioning Scale.ResultsParticipants included 1415 unrelated outpatients diagnosed with schizophrenia or schizoaffective disorder (mean [SD] age, 46 [11] years; 979 males [69.2%] and 619 white [43.7%]). Early auditory information processing had a direct effect on cognition (β = 0.37, P
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- 2017
39. Diminished reward responsiveness is associated with lower reward network GluCEST: an ultra-high field glutamate imaging study
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Sydnor, Valerie J., Larsen, Bart, Kohler, Christian, Crow, Andrew J. D., Rush, Sage L., Calkins, Monica E., Gur, Ruben C., Gur, Raquel E., Ruparel, Kosha, Kable, Joseph W., Young, Jami F., Chawla, Sanjeev, Elliott, Mark A., Shinohara, Russell T., Nanga, Ravi Prakash Reddy, Reddy, Ravinder, Wolf, Daniel H., Satterthwaite, Theodore D., and Roalf, David R.
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- 2021
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40. Concordance and factor structure of subthreshold positive symptoms in youth at clinical high risk for psychosis
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Calkins, Monica E., Woods, Scott W., Bearden, Carrie E., Liu, Lu, Moore, Tyler M., Cadenhead, Kristin S., Cannon, Tyrone D., Cornblatt, Barbara A., McGlashan, Thomas H., Perkins, Diana O., Seidman, Larry J., Tsuang, Ming T., Walker, Elaine F., Mathalon, Daniel H., Keshavan, Matcheri, Stone, William S., and Addington, Jean
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- 2021
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41. Counterpoint. Early intervention for psychosis risk syndromes: Minimizing risk and maximizing benefit
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Woods, Scott W., Bearden, Carrie E., Sabb, Fred W., Stone, William S., Torous, John, Cornblatt, Barbara A., Perkins, Diana O., Cadenhead, Kristin S., Addington, Jean, Powers, Albert R., III, Mathalon, Daniel H., Calkins, Monica E., Wolf, Daniel H., Corcoran, Cheryl M., Horton, Leslie E., Mittal, Vijay A., Schiffman, Jason, Ellman, Lauren M., Strauss, Gregory P., Mamah, Daniel, Choi, Jimmy, Pearlson, Godfrey D., Shah, Jai L., Fusar-Poli, Paolo, Arango, Celso, Perez, Jesus, Koutsouleris, Nikolaos, Wang, Jijun, Kwon, Jun Soo, Walsh, Barbara C., McGlashan, Thomas H., Hyman, Steven E., Gur, Raquel E., Cannon, Tyrone D., Kane, John M., and Anticevic, Alan
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- 2021
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42. Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ):Rationale and Study Design of the Largest Global Prospective Cohort Study of Clinical High Risk for Psychosis
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Wannan, Cassandra M.J., Nelson, Barnaby, Addington, Jean, Allott, Kelly, Anticevic, Alan, Arango, Celso, Baker, Justin T., Bearden, Carrie E., Billah, Tashrif, Bouix, Sylvain, Broome, Matthew R., Buccilli, Kate, Cadenhead, Kristin S., Calkins, Monica E., Cannon, Tyrone D., Cecci, Guillermo, Chen, Eric Yu Hai, Cho, Kang Ik K., Choi, Jimmy, Clark, Scott R., Coleman, Michael J., Conus, Philippe, Corcoran, Cheryl M., Cornblatt, Barbara A., Diaz-Caneja, Covadonga M., Dwyer, Dominic, Ebdrup, Bjørn H., Ellman, Lauren M., Fusar-Poli, Paolo, Galindo, Liliana, Gaspar, Pablo A., Gerber, Carla, Glenthøj, Louise Birkedal, Glynn, Robert, Harms, Michael P., Horton, Leslie E., Kahn, René S., Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Kane, John M., Kapur, Tina, Keshavan, Matcheri S., Kim, Sung Wan, Koutsouleris, Nikolaos, Kubicki, Marek, Kwon, Jun Soo, Langbein, Kerstin, Lewandowski, Kathryn E., Light, Gregory A., Mamah, Daniel, Marcy, Patricia J., Mathalon, Daniel H., McGorry, Patrick D., Mittal, Vijay A., Nordentoft, Merete, Nunez, Angela, Pasternak, Ofer, Pearlson, Godfrey D., Perez, Jesus, Perkins, Diana O., Powers, Albert R., Roalf, David R., Sabb, Fred W., Schiffman, Jason, Shah, Jai L., Smesny, Stefan, Spark, Jessica, Stone, William S., Strauss, Gregory P., Tamayo, Zailyn, Torous, John, Upthegrove, Rachel, Vangel, Mark, Verma, Swapna, Wang, Jijun, Rossum, Inge Winter van, Wolf, Daniel H., Wolff, Phillip, Wood, Stephen J., Yung, Alison R., Agurto, Carla, Alvarez-Jimenez, Mario, Amminger, Paul, Armando, Marco, Asgari-Targhi, Ameneh, Cahill, John, Carrión, Ricardo E., Castro, Eduardo, Cetin-Karayumak, Suheyla, Mallar Chakravarty, M., Cho, Youngsun T., Cotter, David, D'Alfonso, Simon, Ennis, Michaela, Fadnavis, Shreyas, Fonteneau, Clara, Gao, Caroline, Gupta, Tina, Gur, Raquel E., Gur, Ruben C., Hamilton, Holly K., Hoftman, Gil D., Jacobs, Grace R., Jarcho, Johanna, Ji, Jie Lisa, Kohler, Christian G., Lalousis, Paris Alexandros, Lavoie, Suzie, Lepage, Martin, Liebenthal, Einat, Mervis, Josh, Murty, Vishnu, Nicholas, Spero C., Ning, Lipeng, Penzel, Nora, Poldrack, Russell, Polosecki, Pablo, Pratt, Danielle N., Rabin, Rachel, Rahimi Eichi, Habiballah, Rathi, Yogesh, Reichenberg, Avraham, Reinen, Jenna, Rogers, Jack, Ruiz-Yu, Bernalyn, Scott, Isabelle, Seitz-Holland, Johanna, Srihari, Vinod H., Srivastava, Agrima, Thompson, Andrew, Turetsky, Bruce I., Walsh, Barbara C., Whitford, Thomas, Wigman, Johanna T.W., Yao, Beier, Yuen, Hok Pan, Ahmed, Uzair, Byun, Andrew Jin Soo, Chung, Yoonho, Do, Kim, Hendricks, Larry, Huynh, Kevin, Jeffries, Clark, Lane, Erlend, Langholm, Carsten, Lin, Eric, Mantua, Valentina, Santorelli, Gennarina, Ruparel, Kosha, Zoupou, Eirini, Adasme, Tatiana, Addamo, Lauren, Adery, Laura, Ali, Munaza, Auther, Andrea, Aversa, Samantha, Baek, Seon Hwa, Bates, Kelly, Bathery, Alyssa, Bayer, Johanna M.M., Beedham, Rebecca, Bilgrami, Zarina, Birch, Sonia, Bonoldi, Ilaria, Borders, Owen, Borgatti, Renato, Brown, Lisa, Bruna, Alejandro, Carrington, Holly, Castillo-Passi, Rolando I., Chen, Justine, Cheng, Nicholas, Ching, Ann Ee, Clifford, Chloe, Colton, Beau Luke, Contreras, Pamela, Corral, Sebastián, Damiani, Stefano, Done, Monica, Estradé, Andrés, Etuka, Brandon Asika, Formica, Melanie, Furlan, Rachel, Geljic, Mia, Germano, Carmela, Getachew, Ruth, Goncalves, Mathias, Haidar, Anastasia, Hartmann, Jessica, Jo, Anna, John, Omar, Kerins, Sarah, Kerr, Melissa, Kesselring, Irena, Kim, Honey, Kim, Nicholas, Kinney, Kyle, Krcmar, Marija, Kotler, Elana, Lafanechere, Melanie, Lee, Clarice, Llerena, Joshua, Markiewicz, Christopher, Matnejl, Priya, Maturana, Alejandro, Mavambu, Aissata, Mayol-Troncoso, Rocío, McDonnell, Amelia, McGowan, Alessia, McLaughlin, Danielle, McIlhenny, Rebecca, McQueen, Brittany, Mebrahtu, Yohannes, Mensi, Martina, Hui, Christy Lai Ming, Suen, Yi Nam, Wong, Stephanie Ming Yin, Morrell, Neal, Omar, Mariam, Partridge, Alice, Phassouliotis, Christina, Pichiecchio, Anna, Politi, Pierluigi, Porter, Christian, Provenzani, Umberto, Prunier, Nicholas, Raj, Jasmine, Ray, Susan, Rayner, Victoria, Reyes, Manuel, Reynolds, Kate, Rush, Sage, Salinas, Cesar, Shetty, Jashmina, Snowball, Callum, Tod, Sophie, Turra-Fariña, Gabriel, Valle, Daniela, Veale, Simone, Whitson, Sarah, Wickham, Alana, Youn, Sarah, Zamorano, Francisco, Zavaglia, Elissa, Zinberg, Jamie, Woods, Scott W., Shenton, Martha E., Wannan, Cassandra M.J., Nelson, Barnaby, Addington, Jean, Allott, Kelly, Anticevic, Alan, Arango, Celso, Baker, Justin T., Bearden, Carrie E., Billah, Tashrif, Bouix, Sylvain, Broome, Matthew R., Buccilli, Kate, Cadenhead, Kristin S., Calkins, Monica E., Cannon, Tyrone D., Cecci, Guillermo, Chen, Eric Yu Hai, Cho, Kang Ik K., Choi, Jimmy, Clark, Scott R., Coleman, Michael J., Conus, Philippe, Corcoran, Cheryl M., Cornblatt, Barbara A., Diaz-Caneja, Covadonga M., Dwyer, Dominic, Ebdrup, Bjørn H., Ellman, Lauren M., Fusar-Poli, Paolo, Galindo, Liliana, Gaspar, Pablo A., Gerber, Carla, Glenthøj, Louise Birkedal, Glynn, Robert, Harms, Michael P., Horton, Leslie E., Kahn, René S., Kambeitz, Joseph, Kambeitz-Ilankovic, Lana, Kane, John M., Kapur, Tina, Keshavan, Matcheri S., Kim, Sung Wan, Koutsouleris, Nikolaos, Kubicki, Marek, Kwon, Jun Soo, Langbein, Kerstin, Lewandowski, Kathryn E., Light, Gregory A., Mamah, Daniel, Marcy, Patricia J., Mathalon, Daniel H., McGorry, Patrick D., Mittal, Vijay A., Nordentoft, Merete, Nunez, Angela, Pasternak, Ofer, Pearlson, Godfrey D., Perez, Jesus, Perkins, Diana O., Powers, Albert R., Roalf, David R., Sabb, Fred W., Schiffman, Jason, Shah, Jai L., Smesny, Stefan, Spark, Jessica, Stone, William S., Strauss, Gregory P., Tamayo, Zailyn, Torous, John, Upthegrove, Rachel, Vangel, Mark, Verma, Swapna, Wang, Jijun, Rossum, Inge Winter van, Wolf, Daniel H., Wolff, Phillip, Wood, Stephen J., Yung, Alison R., Agurto, Carla, Alvarez-Jimenez, Mario, Amminger, Paul, Armando, Marco, Asgari-Targhi, Ameneh, Cahill, John, Carrión, Ricardo E., Castro, Eduardo, Cetin-Karayumak, Suheyla, Mallar Chakravarty, M., Cho, Youngsun T., Cotter, David, D'Alfonso, Simon, Ennis, Michaela, Fadnavis, Shreyas, Fonteneau, Clara, Gao, Caroline, Gupta, Tina, Gur, Raquel E., Gur, Ruben C., Hamilton, Holly K., Hoftman, Gil D., Jacobs, Grace R., Jarcho, Johanna, Ji, Jie Lisa, Kohler, Christian G., Lalousis, Paris Alexandros, Lavoie, Suzie, Lepage, Martin, Liebenthal, Einat, Mervis, Josh, Murty, Vishnu, Nicholas, Spero C., Ning, Lipeng, Penzel, Nora, Poldrack, Russell, Polosecki, Pablo, Pratt, Danielle N., Rabin, Rachel, Rahimi Eichi, Habiballah, Rathi, Yogesh, Reichenberg, Avraham, Reinen, Jenna, Rogers, Jack, Ruiz-Yu, Bernalyn, Scott, Isabelle, Seitz-Holland, Johanna, Srihari, Vinod H., Srivastava, Agrima, Thompson, Andrew, Turetsky, Bruce I., Walsh, Barbara C., Whitford, Thomas, Wigman, Johanna T.W., Yao, Beier, Yuen, Hok Pan, Ahmed, Uzair, Byun, Andrew Jin Soo, Chung, Yoonho, Do, Kim, Hendricks, Larry, Huynh, Kevin, Jeffries, Clark, Lane, Erlend, Langholm, Carsten, Lin, Eric, Mantua, Valentina, Santorelli, Gennarina, Ruparel, Kosha, Zoupou, Eirini, Adasme, Tatiana, Addamo, Lauren, Adery, Laura, Ali, Munaza, Auther, Andrea, Aversa, Samantha, Baek, Seon Hwa, Bates, Kelly, Bathery, Alyssa, Bayer, Johanna M.M., Beedham, Rebecca, Bilgrami, Zarina, Birch, Sonia, Bonoldi, Ilaria, Borders, Owen, Borgatti, Renato, Brown, Lisa, Bruna, Alejandro, Carrington, Holly, Castillo-Passi, Rolando I., Chen, Justine, Cheng, Nicholas, Ching, Ann Ee, Clifford, Chloe, Colton, Beau Luke, Contreras, Pamela, Corral, Sebastián, Damiani, Stefano, Done, Monica, Estradé, Andrés, Etuka, Brandon Asika, Formica, Melanie, Furlan, Rachel, Geljic, Mia, Germano, Carmela, Getachew, Ruth, Goncalves, Mathias, Haidar, Anastasia, Hartmann, Jessica, Jo, Anna, John, Omar, Kerins, Sarah, Kerr, Melissa, Kesselring, Irena, Kim, Honey, Kim, Nicholas, Kinney, Kyle, Krcmar, Marija, Kotler, Elana, Lafanechere, Melanie, Lee, Clarice, Llerena, Joshua, Markiewicz, Christopher, Matnejl, Priya, Maturana, Alejandro, Mavambu, Aissata, Mayol-Troncoso, Rocío, McDonnell, Amelia, McGowan, Alessia, McLaughlin, Danielle, McIlhenny, Rebecca, McQueen, Brittany, Mebrahtu, Yohannes, Mensi, Martina, Hui, Christy Lai Ming, Suen, Yi Nam, Wong, Stephanie Ming Yin, Morrell, Neal, Omar, Mariam, Partridge, Alice, Phassouliotis, Christina, Pichiecchio, Anna, Politi, Pierluigi, Porter, Christian, Provenzani, Umberto, Prunier, Nicholas, Raj, Jasmine, Ray, Susan, Rayner, Victoria, Reyes, Manuel, Reynolds, Kate, Rush, Sage, Salinas, Cesar, Shetty, Jashmina, Snowball, Callum, Tod, Sophie, Turra-Fariña, Gabriel, Valle, Daniela, Veale, Simone, Whitson, Sarah, Wickham, Alana, Youn, Sarah, Zamorano, Francisco, Zavaglia, Elissa, Zinberg, Jamie, Woods, Scott W., and Shenton, Martha E.
- Abstract
This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals., This article describes the rationale, aims, and methodology of the Accelerating Medicines Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to date that will develop algorithms to predict trajectories and outcomes of individuals at clinical high risk (CHR) for psychosis and to advance the development and use of novel pharmacological interventions for CHR individuals. We present a description of the participating research networks and the data processing analysis and coordination center, their processes for data harmonization across 43 sites from 13 participating countries (recruitment across North America, Australia, Europe, Asia, and South America), data flow and quality assessment processes, data analyses, and the transfer of data to the National Institute of Mental Health (NIMH) Data Archive (NDA) for use by the research community. In an expected sample of approximately 2000 CHR individuals and 640 matched healthy controls, AMP SCZ will collect clinical, environmental, and cognitive data along with multimodal biomarkers, including neuroimaging, electrophysiology, fluid biospecimens, speech and facial expression samples, novel measures derived from digital health technologies including smartphone-based daily surveys, and passive sensing as well as actigraphy. The study will investigate a range of clinical outcomes over a 2-year period, including transition to psychosis, remission or persistence of CHR status, attenuated positive symptoms, persistent negative symptoms, mood and anxiety symptoms, and psychosocial functioning. The global reach of AMP SCZ and its harmonized innovative methods promise to catalyze the development of new treatments to address critical unmet clinical and public health needs in CHR individuals.
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- 2024
43. Development of the PSYCHS:Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS
- Author
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Woods, Scott W., Parker, Sophie, Kerr, Melissa J., Walsh, Barbara C., Wijtenburg, S. Andrea, Prunier, Nicholas, Nunez, Angela R., Buccilli, Kate, Mourgues-Codern, Catalina, Brummitt, Kali, Kinney, Kyle S., Trankler, Carli, Szacilo, Julia, Colton, Beau Luke, Ali, Munaza, Haidar, Anastasia, Billah, Tashrif, Huynh, Kevin, Ahmed, Uzair, Adery, Laura L., Marcy, Patricia J., Allott, Kelly, Amminger, Paul, Arango, Celso, Broome, Matthew R., Cadenhead, Kristin S., Chen, Eric Y. H., Choi, Jimmy, Conus, Philippe, Cornblatt, Barbara A., Glenthøj, Louise Birkedal, Horton, Leslie E., Kambeitz, Joseph, Kapur, Tina, Keshavan, Matcheri S., Koutsouleris, Nikolaos, Langbein, Kerstin, Lavoie, Suzie, Diaz-Caneja, Covadonga Martinez, Mathalon, Daniel H, Mittal, Vijay A., Nordentoft, Merete, Pasternak, Ofer, Pearlson, Godfrey D, Gaspar, Pablo A., Shah, Jai L., Smesny, Stefan, Stone, William S., Strauss, Gregory P., Wang, Jijun, Corcoran, Cheryl M., Perkins, Diana O., Schiffman, Jason, Perez, Jesus, Mamah, Daniel, Ellman, Lauren M., Powers, Albert R., Coleman, Michael J., Anticevic, Alan, Fusar-Poli, Paolo, Kane, John M., Kahn, Rene S., McGorry, Patrick D., Bearden, Carrie E, Shenton, Martha E., Nelson, Barnaby, Calkins, Monica E., Hendricks, Larry, Bouix, Sylvain, Addington, Jean, McGlashan, Thomas H, Yung, Alison R., Woods, Scott W., Parker, Sophie, Kerr, Melissa J., Walsh, Barbara C., Wijtenburg, S. Andrea, Prunier, Nicholas, Nunez, Angela R., Buccilli, Kate, Mourgues-Codern, Catalina, Brummitt, Kali, Kinney, Kyle S., Trankler, Carli, Szacilo, Julia, Colton, Beau Luke, Ali, Munaza, Haidar, Anastasia, Billah, Tashrif, Huynh, Kevin, Ahmed, Uzair, Adery, Laura L., Marcy, Patricia J., Allott, Kelly, Amminger, Paul, Arango, Celso, Broome, Matthew R., Cadenhead, Kristin S., Chen, Eric Y. H., Choi, Jimmy, Conus, Philippe, Cornblatt, Barbara A., Glenthøj, Louise Birkedal, Horton, Leslie E., Kambeitz, Joseph, Kapur, Tina, Keshavan, Matcheri S., Koutsouleris, Nikolaos, Langbein, Kerstin, Lavoie, Suzie, Diaz-Caneja, Covadonga Martinez, Mathalon, Daniel H, Mittal, Vijay A., Nordentoft, Merete, Pasternak, Ofer, Pearlson, Godfrey D, Gaspar, Pablo A., Shah, Jai L., Smesny, Stefan, Stone, William S., Strauss, Gregory P., Wang, Jijun, Corcoran, Cheryl M., Perkins, Diana O., Schiffman, Jason, Perez, Jesus, Mamah, Daniel, Ellman, Lauren M., Powers, Albert R., Coleman, Michael J., Anticevic, Alan, Fusar-Poli, Paolo, Kane, John M., Kahn, Rene S., McGorry, Patrick D., Bearden, Carrie E, Shenton, Martha E., Nelson, Barnaby, Calkins, Monica E., Hendricks, Larry, Bouix, Sylvain, Addington, Jean, McGlashan, Thomas H, and Yung, Alison R.
- Abstract
Aim: To harmonize two ascertainment and severity rating instruments commonly used for the clinical high risk syndrome for psychosis (CHR-P): the Structured Interview for Psychosis-risk Syndromes (SIPS) and the Comprehensive Assessment of At-Risk Mental States (CAARMS). Methods: The initial workshop is described in the companion report from Addington et al. After the workshop, lead experts for each instrument continued harmonizing attenuated positive symptoms and criteria for psychosis and CHR-P through an intensive series of joint videoconferences. Results: Full harmonization was achieved for attenuated positive symptom ratings and psychosis criteria, and modest harmonization for CHR-P criteria. The semi-structured interview, named Positive SYmptoms and Diagnostic Criteria for the CAARMS Harmonized with the SIPS (PSYCHS), generates CHR-P criteria and severity scores for both CAARMS and SIPS. Conclusions: Using the PSYCHS for CHR-P ascertainment, conversion determination, and attenuated positive symptom severity rating will help in comparing findings across studies and in meta-analyses.
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- 2024
44. Neurocognitive and functional heterogeneity in depressed youth
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Baller, Erica B., Kaczkurkin, Antonia N., Sotiras, Aristeidis, Adebimpe, Azeez, Bassett, Danielle S., Calkins, Monica E., Chand, Ganesh B., Cui, Zaixu, Gur, Raquel E., Gur, Ruben C., Linn, Kristin A., Moore, Tyler M., Roalf, David R., Varol, Erdem, Wolf, Daniel H., Xia, Cedric H., Davatzikos, Christos, and Satterthwaite, Theodore D.
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- 2021
- Full Text
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45. Computer-vision analysis of craniofacial dysmorphology in 22q11.2 deletion syndrome and psychosis spectrum disorders.
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Roalf, David R., McDonald-McGinn, Donna M., Jee, Joelle, Krall, Mckenna, Crowley, T. Blaine, Moberg, Paul J., Kohler, Christian, Calkins, Monica E., Crow, Andrew J.D., Fleischer, Nicole, Gallagher, R. Sean, Gonzenbach, Virgilio, Clark, Kelly, Gur, Ruben C., McClellan, Emily, McGinn, Daniel E., Mordy, Arianna, Ruparel, Kosha, Turetsky, Bruce I., and Shinohara, Russell T.
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DIGEORGE syndrome ,22Q11 deletion syndrome ,PSYCHOSES ,AT-risk youth ,DIGITAL photography ,FETAL development - Abstract
Background: Minor physical anomalies (MPAs) are congenital morphological abnormalities linked to disruptions of fetal development. MPAs are common in 22q11.2 deletion syndrome (22q11DS) and psychosis spectrum disorders (PS) and likely represent a disruption of early embryologic development that may help identify overlapping mechanisms linked to psychosis in these disorders. Methods: Here, 2D digital photographs were collected from 22q11DS (n = 150), PS (n = 55), and typically developing (TD; n = 93) individuals. Photographs were analyzed using two computer-vision techniques: (1) DeepGestalt algorithm (Face2Gene (F2G)) technology to identify the presence of genetically mediated facial disorders, and (2) Emotrics—a semi-automated machine learning technique that localizes and measures facial features. Results: F2G reliably identified patients with 22q11DS; faces of PS patients were matched to several genetic conditions including FragileX and 22q11DS. PCA-derived factor loadings of all F2G scores indicated unique and overlapping facial patterns that were related to both 22q11DS and PS. Regional facial measurements of the eyes and nose were smaller in 22q11DS as compared to TD, while PS showed intermediate measurements. Conclusions: The extent to which craniofacial dysmorphology 22q11DS and PS overlapping and evident before the impairment or distress of sub-psychotic symptoms may allow us to identify at-risk youths more reliably and at an earlier stage of development. [ABSTRACT FROM AUTHOR]
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- 2024
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46. Heritability of acoustic startle magnitude and latency from the consortium on the genetics of schizophrenia
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Greenwood, Tiffany A., Swerdlow, Neal R., Sprock, Joyce, Calkins, Monica E., Freedman, Robert, Green, Michael F., Gur, Raquel E., Gur, Ruben C., Lazzeroni, Laura C., Light, Gregory A., Nuechterlein, Keith H., Radant, Allen D., Silverman, Jeremy M., Stone, William S., Sugar, Catherine A., Tsuang, Debby W., Tsuang, Ming T., Turetsky, Bruce I., Braff, David L., and Duncan, Erica
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- 2020
- Full Text
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47. Development of a scale battery for rapid assessment of risk and resilience
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Moore, Tyler M., White, Lauren K., Barzilay, Ran, Calkins, Monica E., Jones, Jason D., Young, Jami F., Gur, Ruben C., and Gur, Raquel E.
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- 2020
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48. Neurostructural Heterogeneity in Youths With Internalizing Symptoms
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Kaczkurkin, Antonia N., Sotiras, Aristeidis, Baller, Erica B., Barzilay, Ran, Calkins, Monica E., Chand, Ganesh B., Cui, Zaixu, Erus, Guray, Fan, Yong, Gur, Raquel E., Gur, Ruben C., Moore, Tyler M., Roalf, David R., Rosen, Adon F.G., Ruparel, Kosha, Shinohara, Russell T., Varol, Erdem, Wolf, Daniel H., Davatzikos, Christos, and Satterthwaite, Theodore D.
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- 2020
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49. Characteristics of youth with reported family history of psychosis spectrum symptoms in the Philadelphia Neurodevelopmental Cohort
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Taylor, Jerome H., Asabere, Nana, Calkins, Monica E., Moore, Tyler M., Tang, Sunny X., Xavier, Rose Mary, Merikangas, Alison K., Wolf, Daniel H., Almasy, Laura, Gur, Ruben C., and Gur, Raquel E.
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- 2020
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50. Gating Deficit Heritability and Correlation With Increased Clinical Severity in Schizophrenia Patients With Positive Family History.
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Greenwood, Tiffany A, Light, Gregory A, Swerdlow, Neal R, Calkins, Monica E, Green, Michael F, Gur, Raquel E, Gur, Ruben C, Lazzeroni, Laura C, Nuechterlein, Keith H, Olincy, Ann, Radant, Allen D, Seidman, Larry J, Siever, Larry J, Silverman, Jeremy M, Stone, William S, Sugar, Catherine A, Tsuang, Debby W, Tsuang, Ming T, Turetsky, Bruce I, Freedman, Robert, and Braff, David L
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Brain ,Humans ,Electroencephalography ,Severity of Illness Index ,Family ,Parents ,Siblings ,Schizophrenia ,Schizophrenic Psychology ,Evoked Potentials ,Adolescent ,Adult ,Aged ,Middle Aged ,Female ,Male ,Young Adult ,Endophenotypes ,Prepulse Inhibition ,Neurosciences ,Clinical Research ,Human Genome ,Brain Disorders ,Genetics ,Mental Health ,Mental health ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry - Abstract
ObjectiveThe Consortium on the Genetics of Schizophrenia Family Study evaluated 12 primary and other supplementary neurocognitive and neurophysiological endophenotypes in schizophrenia probands and their families. Previous analyses of prepulse inhibition (PPI) and P50 gating measures in this sample revealed heritability estimates that were lower than expected based on earlier family studies. Here the authors investigated whether gating measures were more heritable in multiply affected families with a positive family history compared with families with only a single affected proband (singleton).MethodA total of 296 nuclear families consisting of a schizophrenia proband, at least one unaffected sibling, and both parents underwent a comprehensive endophenotype and clinical characterization. The Family Interview for Genetic Studies was administered to all participants and used to obtain convergent psychiatric symptom information for additional first-degree relatives. Among the families, 97 were multiply affected, and 96 were singletons.ResultsBoth PPI and P50 gating displayed substantially increased heritability in the 97 multiply affected families (47% and 36%, respectively) compared with estimates derived from the entire sample of 296 families (29% and 20%, respectively). However, no evidence for heritability was observed for either measure in the 96 singleton families. Schizophrenia probands derived from the multiply affected families also displayed a significantly increased severity of clinical symptoms compared with those from singleton families.ConclusionsPPI and P50 gating measures demonstrate substantially increased heritability in schizophrenia families with a higher genetic vulnerability for illness, providing further support for the commonality of genes underlying both schizophrenia and gating measures.
- Published
- 2016
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