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3. Translational Research on Azacitidine Post-Remission Therapy of Acute Myeloid Leukemia in Elderly Patients (QOL-ONE Trans-2).

Author

Oliva, Esther Natalie, Cuzzola, Maria, Porta, Matteo Della, Candoni, Anna, Salutari, Prassede, Palumbo, Giuseppe A., Reda, Gianluigi, Iannì, Giuseppe, Zampini, Matteo, D'Amico, Saverio, Tripepi, Giovanni, Capelli, Debora, Alati, Caterina, Cannatà, Maria Concetta, Niscola, Pasquale, Serio, Bianca, Barillà, Santina, Musto, Pellegrino, Vigna, Ernesto, and Melillo, Lorella Maria Antonia

Subjects
ACUTE myeloid leukemia, OLDER patients, PROGRESSION-free survival, NUCLEOTIDE sequencing, BONE marrow
Abstract

The achievement of complete remission (CR) is crucial for acute myeloid leukemia (AML) patients undertaking curative therapy, but relapse often occurs within months, highlighting the need for strategies to prolong disease-free survival (DFS). Our phase III study compared the efficacy and safety of azacitidine (AZA) to best supportive care (BSC) in elderly AML patients who achieved CR following intensive induction and consolidation therapy. This ancillary study (QOL-ONE Trans-2) evaluated biological changes in bone marrow using Next-Generation Sequencing (NGS). We analyzed baseline, randomization, and 6-month post-remission samples from 24 patients (median age of 71 and 12 males). High-throughput NGS targeted 350 myeloid malignancy-related genes, considering variants with a variant allele frequency ≥ 4%. At diagnosis, all patients had 5 to 17 (median = 10) mutations, with DNMT3A (42%), NPM1 (33%), and TET2 (33%) being most frequent. FANCA mutations in four patients were linked to a higher relapse risk (HR = 4.96, p = 0.02) for DFS at both 2 and 5 years. Further HLA-specific NGS analyses are ongoing to confirm these results and their therapeutic implications. [ABSTRACT FROM AUTHOR]

Published
2024
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7. GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

Author

Venditti, Adriano, Piciocchi, Alfonso, Candoni, Anna, Melillo, Lorella, Calafiore, Valeria, Cairoli, Roberto, de Fabritiis, Paolo, Storti, Gabriella, Salutari, Prassede, Lanza, Francesco, Martinelli, Giovanni, Luppi, Mario, Mazza, Patrizio, Martelli, Maria Paola, Cuneo, Antonio, Albano, Francesco, Fabbiano, Francesco, Tafuri, Agostino, Chierichini, Anna, Tieghi, Alessia, Fracchiolla, Nicola Stefano, Capelli, Debora, Foà, Robin, Alati, Caterina, La Sala, Edoardo, Fazi, Paola, Vignetti, Marco, Maurillo, Luca, Buccisano, Francesco, Del Principe, Maria Ilaria, Irno-Consalvo, Maria, Ottone, Tiziana, Lavorgna, Serena, Voso, Maria Teresa, Lo-Coco, Francesco, Arcese, William, and Amadori, Sergio

Published
2019
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9. Risk-adapted MRD-directed therapy for young adults with acute myeloid leukemia: 6-year update of the GIMEMA AML1310 trial

Author

Venditti, Adriano, Piciocchi, Alfonso, Candoni, Anna, Arena, Valentina, Palmieri, Raffaele, Filì, Carla, Carella, Angelo Michele, Calafiore, Valeria, Cairoli, Roberto, de Fabritiis, Paolo, Storti, Gabriella, Salutari, Prassede, Lanza, Francesco, Martinelli, Giovanni, Curti, Antonio, Luppi, Mario, Ingrosso, Claudia, Martelli, Maria Paola, Cuneo, Antonio, Albano, Francesco, Mulè, Antonino, Tafuri, Agostino, Cudillo, Laura, Tieghi, Alessia, Fracchiolla, Nicola Stefano, Capelli, Debora, Trisolini, Silvia Maria, Alati, Caterina, La Sala, Edoardo, Maurillo, Luca, Del Principe, Maria Ilaria, Irno Consalvo, Maria Antonietta, Divona, Maria Domenica, Ottone, Tiziana, Cerretti, Raffaella, Sconocchia, Giuseppe, Voso, Maria Teresa, Fazi, Paola, Vignetti, Marco, and Buccisano, Francesco

Published
2024
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10. Prescription patterns of venetoclax in acute myeloid leukemia.

Author

Ucciero, Andrealuna, Traversa, Giuseppe, Pisterna, Alessia, Cardinali, Valeria, Sciabolacci, Sofia, Poloni, Antonella, Capelli, Debora, Gaidano, Gianluca, Patriarca, Andrea, and Lunghi, Monia

Subjects
ACUTE myeloid leukemia, VENETOCLAX, STRUCTURED treatment interruption
Abstract

A study published in the journal Hematological Oncology examined the prescription patterns of venetoclax (VEN) in patients with newly diagnosed acute myeloid leukemia (AML) who are unfit for intensive chemotherapy. The study found that in real-world practice, the average daily dose of VEN was lower than the recommended dose, and most patients experienced multiple dose reductions and interruptions during treatment. Patients who received lower dosages of VEN had higher mortality rates in the following months. The study suggests that further research is needed to evaluate the effect of changes in the dosing schedule on patient outcomes and to identify predictors of sub-optimal adherence to therapy. [Extracted from the article]

Published
2024
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11. Azacitidine Post-Remission Therapy for Elderly Patients with AML: A Randomized Phase-3 Trial (QoLESS AZA-AMLE)

Author

Oliva, Esther Natalie, primary, Candoni, Anna, additional, Salutari, Prassede, additional, Palumbo, Giuseppe A., additional, Reda, Gianluigi, additional, Iannì, Giuseppe, additional, Tripepi, Giovanni, additional, Cuzzola, Maria, additional, Capelli, Debora, additional, Mammì, Corrado, additional, Alati, Caterina, additional, Cannatà, Maria Concetta, additional, Niscola, Pasquale, additional, Serio, Bianca, additional, Musto, Pellegrino, additional, Vigna, Ernesto, additional, Volpe, Antonio, additional, Melillo, Lorella Maria Antonia, additional, Arcadi, Maria Teresa, additional, Mannina, Donato, additional, Zannier, Maria Elena, additional, and Latagliata, Roberto, additional

Published
2023
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12. Optimal Duration of CPX-351 Treatment and Best Timing for Consolidation with Allogeneic Stem Cell Transplantation: Evidence from a Large Real-World Italian Study

Author

Guolo, F, Fianchi, L, Martelli, M, Chiusolo, P, Lussana, F, Grimaldi, F, Pilo, F, Rondoni, M, Fili, C, Capelli, D, Breccia, M, Mastaglio, S, Bocchia, M, Fumagalli, M, Galimberti, S, Mancini, V, Piccioni, A, Maurillo, L, Palmieri, R, Corbingi, A, Vetro, C, Sperotto, A, Gigli, F, Zappasodi, P, Mulé, A, Borlenghi, E, Dargenio, M, Lessi, F, Cerrano, M, Isidori, A, Brunetti, L, Papayannidis, C, Lunghi, M, Alati, C, Gatani, S, Mannelli, F, Fracchiolla, N, Gottardi, M, Cairoli, R, Ferrara, F, Lemoli, R, Venditti, A, Pagano, L, Todisco, E, Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, Todisco, Elisabetta, Guolo, F, Fianchi, L, Martelli, M, Chiusolo, P, Lussana, F, Grimaldi, F, Pilo, F, Rondoni, M, Fili, C, Capelli, D, Breccia, M, Mastaglio, S, Bocchia, M, Fumagalli, M, Galimberti, S, Mancini, V, Piccioni, A, Maurillo, L, Palmieri, R, Corbingi, A, Vetro, C, Sperotto, A, Gigli, F, Zappasodi, P, Mulé, A, Borlenghi, E, Dargenio, M, Lessi, F, Cerrano, M, Isidori, A, Brunetti, L, Papayannidis, C, Lunghi, M, Alati, C, Gatani, S, Mannelli, F, Fracchiolla, N, Gottardi, M, Cairoli, R, Ferrara, F, Lemoli, R, Venditti, A, Pagano, L, Todisco, E, Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, and Todisco, Elisabetta

Published
2023

13. The Time Has Come for Targeted Therapies for AML: Lights and Shadows

Author

Fiorentini, Alessandro, Capelli, Debora, Saraceni, Francesco, Menotti, Diego, Poloni, Antonella, and Olivieri, Attilio

Abstract

Acute myeloid leukemia (AML) is a complex disease characterized by genetic and clinical heterogeneity and high mortality. After 40 years during which the standard of care for patients evolved very little, the therapeutic landscape has recently seen rapid changes, with the approval of eight new drugs by the Food and Drug Administration (FDA) within the last 2 years, providing new opportunities, as well as new challenges, for treating clinicians. These therapies include FLT3 inhibitors midostaurin and gilteritinib, CPX-351 (liposomal cytarabine and daunorubicin), gemtuzumab ozogamicin (GO, anti-CD33 monoclonal antibody conjugated with calicheamicin), IDH1/IDH2 inhibitors ivosidenib and enasidenib, Hedgehog inhibitor glasdegib, and BCL-2 inhibitor venetoclax. In this review, we summarize currently available data on these new drugs and discuss the rapidly evolving therapeutic armamentarium for AML, focusing on targeted therapies.

Published
2024
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14. Mobilization-Driven Postconsolidation Therapy in Elderly Patients with Acute Myeloid Leukemia: Feasibility and Efficacy of Autologous Stem Cell Transplantation versus Low-Dose Gemtuzumab Ozogamicin

Author

Capelli, Debora, Chiarucci, Martina, Poloni, Antonella, Saraceni, Francesco, Mancini, Giorgia, Trappolini, Silvia, Troiani, Emanuela, Montanari, Mauro, Scortechini, Ilaria, Offidani, Massimo, Rupoli, Serena, Scortechini, Anna Rita, Gini, Guido, Discepoli, Giancarlo, Leoni, Pietro, and Olivieri, Attilio

Published
2014
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16. Mechanisms of Resistence of New Target Drugs in Acute Myeloid Leukemia

Author

Capelli, Debora, Olivieri, Attilio, Fiorentini, Alessandro, Menotti, Diego, and Saraceni, Francesco

Subjects
Medical
Abstract

New drugs targeting single mutations have been recently approved for Acute Myeloid Leukemia (AML) treatment, but allogeneic transplant still remains the only curative option in intermediate and unfavorable risk settings, because of the high incidence of relapse. Molecular analysis repertoire permits the identification of the target mutations and drives the choice of target drugs, but the etherogeneity of the disease reduces the curative potential of these agents. Primary and secondary AML resistance to new target agents is actually an intriguing issue and some of these mechanisms have already been explored and identified. Changes in mutations, release of microenvironment factors competing for the same therapeutic target or promoting the survival of blasts or of the leukemic stem cell, the upregulation of the target-downstream pathways and of proteins inhibiting the apoptosis, the inhibition of the cytochrome drug metabolism by other concomitant treatments are some of the recognized patterns of tumor escape. The knowledge of these topics might implement the model of the ‘AML umbrella trial’ study through the combinations or sequences of new target drugs, preemptively targeting known mechanisms of resistance, with the aim to improve the potential curative rates, expecially in elderly patients not eligible to transplant.

Published
2022

17. Complex karyotype, older age, and reduced first-line dose intensity determine poor survival in core binding factor acute myeloid leukemia patients with long-term follow-up

Author

Mosna, Federico, Papayannidis, Cristina, Martinelli, Giovanni, Di Bona, Eros, Bonalumi, Angela, Tecchio, Cristina, Candoni, Anna, Capelli, Debora, Piccin, Andrea, Forghieri, Fabio, Bigazzi, Catia, Visani, Giuseppe, Zambello, Renato, Zanatta, Lucia, Volpato, Francesca, Paolini, Stefania, Testoni, Nicoletta, Gherlinzoni, Filippo, and Gottardi, Michele

Published
2015
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18. Applicability of SIE/Sies/GITMO Fitness Criteria to Therapy-Related and AML-MRC Receiving CPX-351: Results from a Large, Retrospective, Multicentric, Observational Study

Author

Palmieri, Raffaele, Guolo, Fabio, Fianchi, Luana, Ferrara, Felicetto, Martelli, Maria Paola, Rondoni, Michela, Saveria, Capria, Minetto, Paola, Minotti, Clara, Sciabolacci, Sofia, Pilo, Federica, Perrone, Salvatore, Corbingi, Andrea, Grimaldi, Francesco, De Luca, Giulia, Fili, Carla, Alati, Caterina, Mannelli, Francesco, Lessi, Federica, Marchesi, Francesco, Brunetti, Lorenzo, Capelli, Debora, Piccioni, Anna Lina, Vetro, Calogero, Mazzone, Carla, Sperotto, Alessandra, Luzi, Giovanni, Dargenio, Michelina, Mariani, Sabrina, Cerrano, Marco, Mulè, Antonino, Di Veroli, Ambra, Papayannidis, Cristina, Isidori, Alessandro, Lanza, Francesco, Gottardi, Michele, Todisco, Elisabetta, Pagano, Livio, Lemoli, Roberto Massimo, Buccisano, Francesco, and Venditti, Adriano

Published
2023
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19. Novel Gene Mutations Associated with Disease-Free Survival in Elderly Patients with Acute Myeloid Leukemia Receiving First-Line Induction-Consolidation with or without Azacitidine Post-Remission Treatment

Author

Oliva, Esther Natalie, Cuzzola, Maria, Candoni, Anna, Salutari, Prassede, Palumbo, Giuseppe Alberto, Reda, Gianluigi, Ianni', Giuseppe, Tripepi, Giovanni, Capelli, Debora, Alati, Caterina, Cannatà, Maria Concetta, Niscola, Pasquale, Serio, Bianca, Barillà, Santina, Musto, Pellegrino, Vigna, Ernesto, Melillo, Lorella Maria Antonia, Tripepi, Rocco, Delfino, Ilaria Maria, Zannier, Maria Elena, Nannya, Yasuhito, Ogawa, Seishi, and Mammì, Corrado

Published
2023
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20. Late Hematologic Recovery after CPX-351 Induction Chemotherapy in AML: Predictive Disease and Patient's Factors and Their Impact on Survival

Author

Rondoni, Michela, Minetto, Paola, Puglisi, Bruna, Saraceni, Francesco, Brunetti, Lorenzo, Mianulli, Anna Maria, Bocchia, Monica, Santoni, Adele, Riva, Carola, Giannini, Barbara, Monaco, Federica, Zannetti, Beatrice, Cellini, Claudia, Nicoletti, Annalisa, Valenti, Anna Maria, Capelli, Debora, Raspadori, Donatella, Olivieri, Attilio, Lanza, Francesco, Graziano, Claudio, Tosi, Patrizia, Lemoli, Roberto Massimo, and Guolo, Fabio

Published
2023
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21. Optimal Duration of CPX-351 Treatment and Best Timing for Consolidation with Allogeneic Stem Cell Transplantation: Evidence from a Large Real-World Italian Study

Author

Guolo, Fabio, Fianchi, Luana, Martelli, Maria Paola, Chiusolo, Patrizia, Lussana, Federico, Grimaldi, Francesco, Pilo, Federica, Rondoni, Michela, Fili, Carla, Capelli, Debora, Breccia, Massimo, Mastaglio, Sara, Bocchia, Monica, Fumagalli, Monica, Galimberti, Sara, Mancini, Valentina, Piccioni, Anna Lina, Maurillo, Luca, Palmieri, Raffaele, Corbingi, Andrea, Vetro, Calogero, Sperotto, Alessandra, Gigli, Federica, Zappasodi, Patrizia, Mulé, Antonio, Borlenghi, Erika, Dargenio, Michelina, Lessi, Federica, Cerrano, Marco, Isidori, Alessandro, Brunetti, Lorenzo, Papayannidis, Cristina, Lunghi, Monia, Alati, Caterina, Gatani, Samuele, Mannelli, Francesco, Fracchiolla, Nicola, Gottardi, Michele, Cairoli, Roberto, Ferrara, Felicetto, Lemoli, Roberto Massimo, Venditti, Adriano, Pagano, Livio, and Todisco, Elisabetta

Published
2023
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23. Thalidomide, dexamethasone, and pegylated liposomal doxorubicin (ThaDD) for patients older than 65 years with newly diagnosed multiple myeloma

Author

Offidani, Massimo, Corvatta, Laura, Piersantelli, Maria-Novella, Visani, Giuseppe, Alesiani, Francesco, Brunori, Marino, Galieni, Piero, Catarini, Massimo, Burattini, Maurizio, Centurioni, Riccardo, Ferranti, Mario, Rupoli, Serena, Scortechini, Anna Rita, Giuliodori, Luciano, Candela, Marco, Capelli, Debora, Montanari, Mauro, Olivieri, Attilio, Poloni, Antonella, Polloni, Claudia, Marconi, Monica, and Leoni, Pietro

Published
2006
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24. A novel method to evaluate prethawing viability of cryopreserved CD34 + hematopoietic stem cells for autologous transplantation

Author

Marinelli Busilacchi, Elena, primary, Costantini, Andrea, additional, Mancini, Giorgia, additional, Bencivenga, Rossella, additional, Olivieri, Jacopo, additional, Battaglini, Giovanna, additional, Velletri, Laura, additional, Viola, Nadia, additional, Butini, Luca, additional, Capelli, Debora, additional, Poloni, Antonella, additional, and Olivieri, Attilio, additional

Published
2020
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30. Central nervous system fungal infections in allogeneic stem cell transplantation. Outcome of 24 recent cases and literature review

Author

Candoni, Anna, primary, Facchin, Gabriele, additional, Busca, Alessandro, additional, Lazzarotto, Davide, additional, Cattaneo, Chiara, additional, Nadali, Gianpaolo, additional, Klimko, Nicholai, additional, Del Principe, Maria Ilaria, additional, Castagnola, Carlo, additional, Verga, Luisa, additional, Zannier, Maria Elena, additional, Calore, Elisabetta, additional, Capelli, Debora, additional, Perruccio, Katia, additional, Melillo, Lorella, additional, Fanin, Renato, additional, and Pagano, Livio, additional

Published
2019
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31. Azacitidine for Post-Remission Therapy in Elderly Patients with Acute Myeloid Leukemia : Final Results of the Qoless AZA-Amle Randomized Trial

Author

Oliva, Esther Natalie, primary, Candoni, Anna, primary, Salutari, Prassede, primary, Di Raimondo, Francesco, primary, Reda, Gianluigi, primary, Capelli, Debora, primary, Niscola, Pasquale, primary, Selleri, Carmine, primary, Musto, Pellegrino, primary, Vigna, Ernesto, primary, Volpe, Antonio, primary, Cascavilla, Nicola, primary, Mannina, Donato, primary, Carluccio, Paola, primary, Zannier, Maria Elena, primary, Mauro, Elisa, primary, Freyrie, Alessandra, primary, Mazzone, Carla, primary, Martino, Bruno, primary, and Alati, Caterina, primary

Published
2019
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32. A novel method to evaluate prethawing viability of cryopreserved CD34+ hematopoietic stem cells for autologous transplantation.

Author

Marinelli Busilacchi, Elena, Costantini, Andrea, Mancini, Giorgia, Bencivenga, Rossella, Olivieri, Jacopo, Battaglini, Giovanna, Velletri, Laura, Viola, Nadia, Butini, Luca, Capelli, Debora, Poloni, Antonella, and Olivieri, Attilio

Subjects
HEMATOPOIETIC stem cell transplantation, HEMATOPOIETIC stem cells, HEMAPHERESIS, LEUCOCYTES, AUTOGRAFTS, MOTHERS, CELL physiology, CRYOPRESERVATION of organs, tissues, etc., ANTIGENS
Abstract

Background: Cryopreservation of CD34+ hematopoietic stem cells (HSCs) is associated with variable loss of viability. Although postfreezing CD34+ cell viability can be assessed on the sampling tube (bag tail) directly connected to the main bag (mother bag), results often underestimate the actual viability observed when the mother bag is thawed and reinfused. We assessed a novel method to measure postfreezing CD34+ cell viability, based on small bag (minibag) samples; results were compared with those obtained on the corresponding mother bags and bag tails.Study Design and Methods: Sixty-one apheresis procedures of 42 patients undergoing autologous HSC transplant were analyzed. Viable CD34+ cells were quantified with flow cytometry before controlled rate freezing (ICE-CUBE14M system, SY-LAB- IceCube, SIAD), after 10 days of storage (mini-bag and bag tail), and before reinfusion (aliquot from a thawed mother bag). Results were compared using Student's t test and Spearman's rho correlation test.Results: The mean CD34+ cell viability before cryopreservation was 99.3% (confidence interval [CI], 98.94-99.65%); the mean amount of CD34+ cells, white blood cells and neutrophils in the mother bag was 0.8 ± 1.1 × 109 /L, 63.4 ± 23.5 × 109 /L, and 25.7 ± 15.5 × 109 /L, respectively. Mother bags postthawing CD34+ cell viability was 72.3% (CI, 67.74-76.85%; p < 0.01 compared to prefreezing); no difference was observed with respect to minibags (73.7%; CI, 69.80-77.59%; p = NS), whereas significantly lower values were found for bag tails (58.6%; CI, 54.19-63.00%; p < 0.01 vs. both mini- and mother bags).Conclusion: Compared to bag tails, minibags represent a more accurate tool to measure the CD34+ cell viability of the apheresis mother bag prior to reinfusion; in addition, minibags may could be of help for case-by-case calculation of the amount of apheresis to be infused to patients undergoing autologous HSC transplant. [ABSTRACT FROM AUTHOR]

Published
2020
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35. Survival and outcome data observed in 98 patients affected by acute myeloid leukemia undergoing chemotherapy consolidation courses treatment followed by autologous bone marrow transplantation (auto-BMT).

Author

Marconi, Giovanni, primary, Papayannidis, Cristina, additional, Mosna, Federico, additional, Gottardi, Michele, additional, Tenti, Elena, additional, Franchini, Eugenia, additional, Ghelli Luserna di Rorà, Andrea, additional, Ottaviani, Emanuela, additional, Fontana, Maria Chiara, additional, Simonetti, Giorgia, additional, Guadagnuolo, Viviana, additional, Manfrini, Marco, additional, Capelli, Debora, additional, Galieni, Piero, additional, Piccin, Andrea, additional, Visani, Giuseppe, additional, Rodeghiero, Francesco, additional, Tecchio, Cristina, additional, Gherlinzoni, Filippo, additional, and Martinelli, Giovanni, additional

Published
2016
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36. Central nervous system fungal infections in allogeneic stem cell transplantation. Outcome of 24 recent cases and literature review.

Author

Candoni, Anna, Facchin, Gabriele, Busca, Alessandro, Lazzarotto, Davide, Cattaneo, Chiara, Nadali, Gianpaolo, Klimko, Nicholai, Del Principe, Maria Ilaria, Castagnola, Carlo, Verga, Luisa, Zannier, Maria Elena, Calore, Elisabetta, Capelli, Debora, Perruccio, Katia, Melillo, Lorella, Fanin, Renato, and Pagano, Livio

Subjects
CENTRAL nervous system infections, STEM cell transplantation, LITERATURE reviews, CORD blood transplantation, HEMATOPOIETIC stem cell transplantation
Abstract

Invasive fungal infections of the central nervous system (IFI-CNS) are rare and life-threatening complications in hematologic patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). The median patient age was 39 years (range 12-63), and acute leukemia was the most common underlying disease (71%); 16 patients received an allo-HSCT from matched unrelated donors (MUD), 4 from HLA-identical sibling donors and 4 from haploidentical family donor. Regarding new treatment options, a recent retrospective analysis of 36 patients with IFI-CNS provides evidence of good efficacy of isavuconazole therapy with an overall response rate of 58%. [Extracted from the article]

Published
2020
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37. Quality of Life in Elderly Patients with Acute Myeloid Leukemia Undergoing Induction Chemotherapy

Author

Oliva, Esther Natalie, primary, Salutari, Prassede, additional, Candoni, Anna, additional, Freyrie, Alessandra, additional, Capelli, Debora, additional, Di Raimondo, Francesco, additional, Volpe, Antonio, additional, Cascavilla, Nicola, additional, Di Bartolomeo, Paolo, additional, Simeone, Erica, additional, Cortelezzi, Agostino, additional, Leoni, Pietro, additional, Musto, Pellegrino, additional, Morabito, Fortunato, additional, Niscola, Pasquale, additional, Ranieri, Natale, additional, Santacaterina, Irene, additional, Marino, Antonio Giovanni, additional, Cufari, Patrizia, additional, Alati, Caterina, additional, and Ronco, Francesca, additional

Published
2015
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38. Two or More Chemotherapy Consolidation Courses, Followed By Autologous Bone Marrow Transplantation, and MRD Negativity, Give Long Term Overall Survival in Acute Myeloid Leukemia Patients

Author

Marconi, Giovanni, primary, Papayannidis, Cristina, additional, Mosna, Federico, additional, Gottardi, Michele, additional, Simonetti, Giorgia, additional, Soverini, Simona, additional, Curti, Antonio, additional, Zuffa, Elisa, additional, Abbenante, Maria Chiara, additional, Parisi, Sarah, additional, Paolini, Stefania, additional, Sartor, Chiara, additional, Franchini, Eugenia, additional, Ottaviani, Emanuela, additional, Venturi, Claudia, additional, Fontana, Maria Chiara, additional, Padella, Antonella, additional, Guadagnuolo, Viviana, additional, Bochicchio, Maria Teresa, additional, Ferrari, Anna, additional, Testoni, Nicoletta, additional, Baldazzi, Carmen, additional, Manfrini, Marco, additional, Capelli, Debora, additional, Galieni, Piero, additional, Piccin, Andrea, additional, Visani, Giuseppe, additional, Rodeghiero, Francesco, additional, Tecchio, Cristina, additional, Gherlinzoni, Filippo, additional, Cavo, Michele, additional, and Martinelli, Giovanni, additional

Published
2015
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41. A Combination of Lenalidomide and Rituximab (ReRi) As Salvage Therapy in Elderly Patients Affected By Diffuse Large B Cells (DLBCL) Lymphoma Relapsed and Refractory

Author

Gini, Guido, primary, Bocci, Caterina, additional, Sampaolo, Michela, additional, Trappolini, Silvia, additional, Cacciagiù, Sonia, additional, Olivieri, Jacopo, additional, Olivieri, Attilio, additional, Offidani, Massimo, additional, Rupoli, Serena, additional, Poloni, Antonella, additional, Scortechini, Anna Rita, additional, Capelli, Debora, additional, Montanari, Mauro, additional, Scortechini, Ilaria, additional, and Leoni, Pietro, additional

Published
2015
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42. Rosai-Dorfman Disease Involving Bone Marrow in Association With Acute Myeloid Leukemia.

Author

Zanelli, Magda, Goteri, Gaia, Mengoli, Maria Cecilia, Capelli, Debora, De Marco, Loredana, Valli, Riccardo, Zizzo, Maurizio, and Ascani, Stefano

Subjects
RARE diseases, PANCYTOPENIA, SKIN diseases, BONE marrow, ACUTE myeloid leukemia
Abstract

The article presents a case study of a 75-year-old male with mild pancytopenia, clinical history included a cutaneous lesion. It discusses the trephine biopsy showed a hypercellular marrow with a diffuse proliferation of medium-/large-sized cells with a high nuclear-cytoplasmic ratio. It discusses the Rosai-Dorfman disease Involving bone marrow in association with acute myeloid leukemia. It also mentions the identification of sinus histiocytosis with massive lymphadenopathy.

Published
2019
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43. Primary B-cell lymphoblastic lymphoma of the testis

Author

Tombolini, Flavia, primary, Lacetera, Vito, additional, Gini, Guido, additional, Capelli, Debora, additional, Leoni, Pietro, additional, Montironi, Rodolfo, additional, Galosi, Andrea Benedetto, additional, and Muzzonigro, Giovanni, additional

Published
2014
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44. Preventive Effects of Cardotoxicities By Liposomal Anthracyclines non Pegilated in 95 Perspective Patients Affected By Lymphoma and Monitored By Biomarkers and Ecocardiography

Author

Gini, Guido, primary, Olivieri, Jacopo, additional, Bocci, Caterina, additional, Sampaolo, Michela, additional, Trappolini, Silvia, additional, Olivieri, Attilio, additional, Offidani, Massimo, additional, Rupoli, Serena, additional, Poloni, Antonella, additional, Scortechini, Anna Rita, additional, Capelli, Debora, additional, Montanari, Mauro, additional, Scortechini, Ilaria, additional, Perna, Gian Piero, additional, and Leoni, Pietro, additional

Published
2014
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45. Azacitidine As Post-Remission Therapy in Elderly Patients with Acute Myeloid Leukemia Significantly Prolongs Disease-Free Survival: Interim Results from a Prospective, Randomized, Open-Label, Phase III Multicenter Trial

Author

Oliva, Esther Natalie, primary, Alati, Caterina, additional, Salutari, Prassede, additional, Freyrie, Alessandra, additional, Candoni, Anna, additional, Simeone, Erica, additional, Ventura, Giovanna, additional, Cortelezzi, Agostino, additional, Capelli, Debora, additional, Leoni, Pietro, additional, Di Bartolomeo, Paolo, additional, Marino, Antonio Giovanni, additional, Cufari, Patrizia, additional, Di Raimondo, Francesco, additional, Mauro, Elisa, additional, Volpe, Antonio, additional, Cascavilla, Nicola, additional, Musto, Pellegrino, additional, Morabito, Fortunato, additional, Niscola, Pasquale, additional, Specchia, Giorgina, additional, and Ronco, Francesca, additional

Published
2014
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46. A Randomized Open-Label Study To Evaluate The Efficacy Of Azacitidine For Post-Remission Therapy Of Acute Myeloid Leukemia In Elderly Patients (QOLESS AZA-AMLE)

Author

Oliva, Esther Natalie, primary, Santarone, Stella, additional, Leoni, Pietro, additional, Alati, Caterina, additional, Volpe, Antonio, additional, Cascavilla, Nicola, additional, Candoni, Anna, additional, Musto, Pellegrino, additional, Morabito, Fortunato, additional, Di Raimondo, Francesco, additional, Cufari, Patrizia, additional, Santacaterina, Irene, additional, Vincelli, Iolanda, additional, Capelli, Debora, additional, Freyrie, Alessandra, additional, Salutari, Prassede, additional, Di Bartolomeo, Paolo, additional, Martino, Bruno, additional, Ronco, Francesca, additional, and Cortelezzi, Agostino, additional

Published
2013
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47. Geriatric Assessment Driven Treatment In 149 AML Elderly Patients

Author

Capelli, Debora, primary, Saraceni, Francesco, additional, Chiarucci, Martina, additional, Poloni, Antonella, additional, Mancini, Giorgia, additional, Trappolini, Silvia, additional, Offidani, Massimo, additional, Rupoli, Serena, additional, Montanari, Mauro, additional, Scortechini, Anna Rita, additional, Gini, Guido, additional, Scortechini, Ilaria, additional, Discepoli, Giancarlo, additional, Leoni, Pietro, additional, and Olivieri, Attilio, additional

Published
2013
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48. Conditioning regimen with BCNU, etoposide, cytarabine and melphalan plus amifostine for outpatient autologous stem cell transplant: feasibility and outcome in 97 patients with lymphoma

Author

Scortechini, Ilaria, primary, Montanari, Mauro, additional, Mancini, Giorgia, additional, Inglese, Elena, additional, Calandrelli, Monica, additional, Chiarucci, Martina, additional, Offidani, Massimo, additional, Capelli, Debora, additional, Gini, Guido, additional, Poloni, Antonella, additional, Mancini, Stefania, additional, Raggetti, Gianmario, additional, Leoni, Pietro, additional, and Olivieri, Attilio, additional

Published
2013
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49. Efficacy and Feasibility of High-Dose Cytarabine Plus Idarubicin and Amifostine As Induction Schedule: A Prospective Observational Study of 100 AML Elderly Fit Patients

Author

Capelli, Debora, primary, Chiarucci, Martina, additional, Saraceni, Francesco, additional, Poloni, Antonella, additional, Montanari, Mauro, additional, Offidani, Massimo, additional, Rupoli, Serena, additional, Scortechini, Anna Rita, additional, Gini, Guido, additional, Scortechini, Ilaria, additional, Leoni, Pietro, additional, and Olivieri, Attilio, additional

Published
2012
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50. LATE EFFECTS IN Hodgkin's POPULATION Treated BETWEEN 1980-2005 IN A SINGLE INSTITUTION.

Author

Gini, Guido, primary, Caraffa, Patrizia, additional, Offidani, Massimo, additional, Trappolini, Silvia, additional, Bocci, Caterina, additional, Stronati, Andrea, additional, Corvatta, Laura, additional, Polloni, Claudia, additional, Gentili, Silvia, additional, Savini, Agnese, additional, Montanari, Mauro, additional, Capelli, Debora, additional, Poloni, Antonella, additional, Olivieri, Attilio, additional, and Leoni, Pietro, additional

Published
2009
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