45 results on '"Charuvanij, Sirirat"'
Search Results
2. Outcomes of intraarticular triamcinolone acetonide injection in children with non-systemic juvenile idiopathic arthritis
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Sukharomana, Maynart and Charuvanij, Sirirat
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- 2023
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3. Outcomes of achieving lupus low disease activity state and damage accrual in childhood-onset systemic lupus erythematosus
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Na Nakorn, Koravich, Piyaphanee, Nuntawan, Sukharomana, Maynart, Pinpatanapong, Rattakorn, and Charuvanij, Sirirat
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- 2023
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4. Synovial osteochondromatosis mimicking juvenile idiopathic arthritis in an adolescent: a case-based review
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Yothakol, Napapas, Charuvanij, Sirirat, Siriwanarangsun, Palanan, Lertwanich, Pisit, Muangsomboon, Sorranart, and Sukharomana, Maynart
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- 2022
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5. Impact of the COVID-19 pandemic on the quality of care for juvenile idiopathic arthritis patients: insights from Thailand.
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Pinpattanapong, Rattakorn, Sukharomana, Maynart, and Charuvanij, Sirirat
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JUVENILE idiopathic arthritis ,DISEASE incidence ,COVID-19 pandemic ,CAREGIVERS ,COVID-19 vaccines - Abstract
Background: The COVID-19 pandemic has significantly impacted individuals with chronic conditions. This investigation assessed the quality of care provided to pediatric and adolescent patients with juvenile idiopathic arthritis (JIA) during the pandemic in Thailand. Methods: This cross-sectional analysis enrolled JIA patients aged ≤ 18 years at an academic tertiary care facility from April 2022 to March 2023. Retrospective reviews were performed, complemented by patient and caregiver questionnaires to assess the pandemic's impact on care quality. Results: Seventy JIA patients (37 males, 33 females) with a mean age of 13.5 ± 3.1 years were included. A total of 41.4% of the caregivers reported negative impacts on JIA care due to the pandemic and the lockdown, and 31.4% of the patients experienced pandemic-related anxiety. A comparison between the pandemic and prepandemic periods revealed a higher incidence of active disease, although the difference was statistically nonsignificant (37.1% vs 14.2%, p = 0.106). Nonadherence significantly predicted active disease status (adjusted OR 15.04, 95% CI 2.48–91.15, p = 0.03). COVID-19 vaccinations were administered to 85.7% of patients; 52.8% of whom contracted mild COVID-19. Most patients (71.4%) postponed clinic visits; 36% due to lockdowns and 28% due to concerns about COVID-19 exposure in healthcare settings. The majority of patients received telephone JIA management advice from rheumatologists during the lockdown (91.4%). Conclusions: The COVID-19 pandemic and associated lockdown measures affected the care of JIA patients, impacting both physical and mental health. Nonadherence was a critical factor in disease flare-ups. Telemedicine is indispensable for patient care. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Prevalence of HLA-B27, clinical characteristics and treatment outcomes in children with enthesitis-related arthritis.
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Jittawattanarat, Boonsiri, Charuvanij, Sirirat, Tangcheewinsirikul, Sirikarn, and Sukharomana, Maynart
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JUVENILE idiopathic arthritis ,HLA-B27 antigen ,JUVENILE diseases ,SPONDYLOARTHROPATHIES ,PEDIATRIC rheumatology - Abstract
Background: Enthesitis-related arthritis (ERA) is a subtype of juvenile idiopathic arthritis with high disease burden. The objectives of this study were to explore the prevalence of HLA-B27, clinical characteristics, and treatment outcomes in children with ERA and compare the differences between HLA-B27 positive and negative patients. Methods: A retrospective cohort study at a pediatric rheumatology clinic in a tertiary referral hospital in Bangkok, Thailand, including ERA patients with at least 6 months of follow-up (July 2011-April 2022) was performed. Data were collected from medical records from diagnosis to recent follow-up, assessing disease activity and treatment outcomes, with an analysis comparing HLA-B27 positive and negative patients. Descriptive statistics were used for data analysis. Results: There were 59 ERA patients with mean age ± SD at diagnosis 11.2 ± 2.5 years, 53 males (89.8%), and positive HLA-B27 in 38 patients (64.4%). The HLA-B27 positive group had significantly higher levels of inflammatory markers at initial diagnosis (p = 0.001), lower baseline hemoglobin (p = 0.001) and hematocrit (p = 0.002), higher disease activity assessed by the Juvenile Spondyloarthritis Disease Activity score at 6 and 12 months of follow-up (p = 0.028 and 0.040, respectively), increased utilization of bridging systemic corticosteroids (60.5% vs. 14.3%, p = 0.001) and anti-TNF (39.5% vs. 9.5%, p = 0.018), and longer duration of methotrexate (median[IQR] 1.7[1.1–3.1] vs. 1.3[0.6–1.9] years, p = 0.040). The HLA-B27 negative group had more prevalent hip arthritis than the positive group at initial diagnosis (66.7% vs. 28.9%, p = 0.005) and during the course of the disease (71.4% vs. 36.8%, p = 0.011). Conclusion: Most of the ERA patients tested positive for HLA-B27. Throughout the follow-up period, these patients demonstrated greater disease activity, greater use of corticosteroids and anti-TNF, and longer duration of methotrexate to control the disease. Key points: • HLA-B27 was tested positive in nearly two-thirds of enthesitis-related arthritis (ERA) patients. • ERA patients with positive HLA-B27 had significantly higher levels of inflammatory markers with lower hemoglobin and hematocrit at initial diagnosis, increased disease activity assessed by the Juvenile Spondyloarthritis Disease Activity (JSpADA) score at 6 and 12 months of follow-up, greater utilization of bridging systemic corticosteroids and anti-TNF, and longer duration of methotrexate use. • ERA patients with negative HLA-B27 had more prevalent hip arthritis at initial diagnosis and during disease course. • Application of the Assessment of SpondyloArthritis international Society (ASAS) classification for adult spondyloarthritis in ERA patients who entered adulthood showed the predominance of peripheral spondyloarthritis in more than half of the patients. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Musculoskeletal manifestations in childhood-onset systemic lupus erythematosus: an in-depth exploration.
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Sukharomana, Maynart, Vonginyoo, Siritida, Piyaphanee, Nuntawan, and Charuvanij, Sirirat
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RISK assessment ,STATISTICAL correlation ,MUSCULOSKELETAL system diseases ,BALDNESS ,INFECTIOUS arthritis ,FISHER exact test ,SYSTEMIC lupus erythematosus ,RETROSPECTIVE studies ,MANN Whitney U Test ,CHI-squared test ,DESCRIPTIVE statistics ,AGE factors in disease ,LONGITUDINAL method ,MEDICAL records ,ACQUISITION of data ,ELECTRONIC health records ,PAIN ,ARTHRITIS ,JOINT pain ,DATA analysis software ,OSTEONECROSIS ,DISEASE risk factors ,DISEASE complications ,SYMPTOMS - Abstract
Background: Childhood-onset systemic lupus erythematosus (c-SLE) is a multifaceted autoimmune disorder predominantly affecting the musculoskeletal (MSK) system. This investigation delineated the spectrum and sequelae of MSK involvement in c-SLE patients. Methods: This retrospective analysis included SLE patients aged ≤ 18 years treated at a tertiary center between 2009 and 2019. Data were extracted from electronic health records. Results: The cohort comprised 321 SLE patients (mean age 13.2 ± 2.5 years, 91.3% female). MSK manifestations were observed in 134 (41.7%) individuals, with joint pain universally present, followed by joint swelling in 32.1% and morning stiffness in 9.7%. Arthritis was documented in 52 (38.8%) patients, whereas 82 (61.2%) had arthralgia. Symmetrical joint involvement was observed in 96 (71.7%) subjects. The knees, wrists, and fingers were most commonly affected, with incidences of 43.3%, 40.3%, and 33.6%, respectively. Neither erosive arthritis nor Jaccoud's arthropathy was detected. MSK symptoms were significantly correlated with older age at diagnosis, the presence of non-scarring alopecia, neuropsychiatric manifestations, and elevated SLE disease activity index scores at diagnosis. Over a median follow-up of 53.6 months (IQR 26.1–84.6), five patients developed septic arthritis or osteomyelitis, and avascular necrosis was identified in 16 (4.9%) patients. Conclusions: Nearly half of c-SLE patients demonstrated MSK manifestations, chiefly characterized by symmetrical involvement of both large and small joints without evidence of erosive arthritis or Jaccoud's arthropathy. Avascular necrosis is a critical concern and warrants close monitoring. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Correction: Implementation and assessment of a structured curriculum for a 4-week pediatric rheumatology rotation for pediatric residents
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Sukharomana, Maynart, primary and Charuvanij, Sirirat, additional
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- 2024
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9. Implementation and assessment of a structured curriculum for a 4-week pediatric rheumatology rotation for pediatric residents
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Sukharomana, Maynart, primary and Charuvanij, Sirirat, additional
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- 2024
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10. Immunogenicity and safety of BNT162b2 vaccination in adolescents with systemic lupus erythematosus.
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Piyaphanee, Nuntawan, Charuvanij, Sirirat, Thepveera, Sutheera, Toh, Zheng Quan, Licciardi, Paul V., Pattaragarn, Anirut, Wongprompitak, Patimaporn, Boonnak, Kobporn, Pheerapanyawaranun, Chatkamol, and Chokephaibulkit, Kulkanya
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SYSTEMIC lupus erythematosus , *IMMUNE response , *COVID-19 vaccines , *VACCINE effectiveness , *SARS-CoV-2 Omicron variant - Abstract
Objectives: We evaluated the immunogenicity and safety of BNT162b2 vaccination in adolescents with systemic lupus erythematosus (adoSLE) receiving either high- or low-dose immunosuppressant (High-IS and Low-IS). Methods: Patients aged 12–18 years diagnosed with SLE were enrolled. High-IS was defined as >7.5 mg/day prednisolone or with other immunosuppressant, while Low-IS was defined as only ≤7.5 mg/day of prednisolone and no immunosuppressant. Two doses of BNT162b2 vaccination were given 4 weeks apart, followed by a booster (third) dose at 4–6 months later. Anti-spike receptor binding domain (anti-RBD) IgG against Wuhan, neutralising antibody (NT) against Wuhan and Omicron variants, and cellular immune response by IFN-γ-ELISpot assay were evaluated following vaccination. Adverse events (AEs) and SLE flare were monitored. Results: A total of 73 participants were enrolled, 40 and 33 in the High-IS and Low-IS group, respectively. At 4 weeks following the 2nd dose, overall anti-RBD IgG seropositivity was 97.3%, with no difference between the groups (p =.498). AdoSLE on High-IS had lower anti-RBD IgG (p <.001), Wuhan NT (p <.001), and IFN-γ-ELISpot (p =.022) than those on Low-IS. A 3rd dose induced significantly higher antibody responses than after the 2nd dose (p <.001) in both groups and established seroconversion against Omicron variants, with persistent lower antibody levels in High-IS group. SELENA-SLEDAI scores within 12 weeks after 2-dose vaccination was higher than before vaccination (3.1 vs 2.5; p <.036); however, the occurrence of disease flare by SELENA-SLEDAI flare index was not different after vaccination compared to before vaccination, consistent across groups. Non-severe AEs occurred similarly in both groups. Conclusion: AdoSLE on High-IS induced lower SARS-CoV-2 vaccine immune responses than Low-IS. Vaccination can increase disease activity and requires close monitoring for disease flare. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Delivery of paediatric rheumatology care: a survey of current clinical practice in Southeast Asia and Asia-Pacific regions
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Tangcheewinsirikul, Sirikarn, Tang, Swee-Ping, Smith, Nicola, Sukharomana, Maynart, Charuvanij, Sirirat, Vilaiyuk, Soamarat, Arkachaisri, Thaschawee, Scott, Christiaan, and Foster, Helen E.
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- 2021
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12. Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints
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Jeamsripong, Satita and Charuvanij, Sirirat
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- 2020
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13. The Thai Translation of the Pediatric Gait, Arms, Legs, Spine Tool is Useful for Pediatric Residents in Detecting Musculoskeletal Abnormalities in Children
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Sukharomana, Maynart and Charuvanij, Sirirat
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- 2020
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14. Outcomes in children with rheumatic diseases following COVID-19 vaccination and infection: data from a large two-center cohort study in Thailand
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Lerkvaleekul, Butsabong, primary, Charuvanij, Sirirat, additional, Sukharomana, Maynart, additional, Pirojsakul, Kwanchai, additional, Kamolwatwong, Malisa, additional, and Vilaiyuk, Soamarat, additional
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- 2023
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15. Bone Mineral Density and Serum 25OHD in Children and Adolescents With Juvenile Idiopathic Arthritis
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Charuvanij, Sirirat, primary, Malakorn, Hathaikan, additional, Densupsoontorn, Narumon, additional, and Nakavachara, Pairunyar, additional
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- 2022
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16. Neonatal Multisystem Inflammatory Syndrome (MIS-N): The First Case Report in Thailand
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Sojisirikul, Nophathai, primary, Lapphra, Keswadee, additional, Ngerncham, Sopapan, additional, Charuvanij, Sirirat, additional, Durongpisitkul, Kritvikrom, additional, Curlin, Marcel E., additional, and Chokephaibulkit, Kulkanya, additional
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- 2022
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17. Comparison of the outcomes between early and late anti-tumor necrosis factor therapy in patients with enthesitis-related subcategory of juvenile idiopathic arthritis: a multi-center study in Southeast Asia
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Vilaiyuk, Soamarat, primary, Lerkvaleekul, Butsabong, additional, Jino, Janejira, additional, Charuvanij, Sirirat, additional, Book, Yun Xin, additional, and Arkachaisri, Thaschawee, additional
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- 2022
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18. Bone Mineral Density and Serum 25OHD in Children and Adolescents With Juvenile Idiopathic Arthritis.
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Charuvanij, Sirirat, Malakorn, Hathaikan, Densupsoontorn, Narumon, and Nakavachara, Pairunyar
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CONFIDENCE intervals , *PHOTON absorptiometry , *CROSS-sectional method , *JUVENILE idiopathic arthritis , *VITAMIN D , *RESEARCH funding , *BONE density , *CHILDREN , *ADOLESCENCE - Abstract
Low bone mass is one of the complications of juvenile idiopathic arthritis (JIA). However, a study focusing on the low bone mass in children and adolescents with JIA in Southeast Asian countries is limited. This study aimed to evaluate the bone mineral density (BMD) of Thai patients with JIA and identify factors correlated with BMD. A cross-sectional study was conducted at a tertiary-care center. The BMD of the lumbar spines (BMDLS) and the total body (BMDTB) were measured by dual-energy X-ray absorptiometry. Thirty-eight patients were enrolled between July 2015 and January 2016. No patient had low BMDLS, and only 2 (5.3%) had low BMDTB. Serum 25-hydroxyvitamin D (25OHD) levels were significantly positively correlated with the BMDTB Z -score (coefficient: 0.047; 95% confidence interval = 0.011-0.082; P =.012). Our study demonstrated a very low prevalence of low bone mass. Optimization of the serum 25OHD level should be encouraged. [ABSTRACT FROM AUTHOR]
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- 2023
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19. Paediatric rheumatology clinic population in Southeast Asia: are we different?
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Arkachaisri, Thaschawee, Tang, Swee-Ping, Daengsuwan, Tassalapa, Phongsamart, Gun, Vilaiyuk, Soamarat, Charuvanij, Sirirat, Hoh, Sook Fun, Tan, Justin Hung Tiong, Das, Lena, Ang, Elizabeth, Lim, Wendy, Chan, Yiong Huak, and Bernal, Christine B.
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- 2017
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20. Clinical profiles of post‐infectious arthritis and transient synovitis of the hip in children
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Ananthanathorn, Paween, primary, Sukharomana, Maynart, additional, and Charuvanij, Sirirat, additional
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- 2022
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21. Juvenile dermatomyositis in Thai children: Retrospective review of 30 cases from a tertiary care center
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Nitiyarom, Rattanavalai, primary, Charuvanij, Sirirat, additional, Likasitwattanakul, Surachai, additional, Thanoophunchai, Chaiwat, additional, and Wisuthsarewong, Wanee, additional
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- 2021
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22. Attitudes toward pediatric rheumatology among residency‐trained pediatricians
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Chowichian, Monthira, primary, Sonjaipanich, Suprapath, additional, and Charuvanij, Sirirat, additional
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- 2021
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23. Additional file 1 of Delivery of paediatric rheumatology care: a survey of current clinical practice in Southeast Asia and Asia-Pacific regions
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Sirikarn Tangcheewinsirikul, Swee-Ping Tang, Smith, Nicola, Maynart Sukharomana, Charuvanij, Sirirat, Soamarat Vilaiyuk, Thaschawee Arkachaisri, Scott, Christiaan, and Foster, Helen E.
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Data_FILES - Abstract
Additional file 1.
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- 2021
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24. Improving musculoskeletal health for children and young people – A ‘call to action’
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Foster, Helen E., primary, Scott, Christiaan, additional, Tiderius, Carl J., additional, Dobbs, Matthew B., additional, Ang, Elizabeth, additional, Charuvanij, Sirirat, additional, Costello, Wendy, additional, Kinnunen, Marja, additional, Lewandowski, Laura B., additional, Migowa, Angela, additional, Stones, Simon R., additional, Vilaiyuk, Soamarat, additional, and Webb, Kate, additional
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- 2020
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25. Juvenile dermatomyositis in Thai children: Retrospective review of 30 cases from a tertiary care center.
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Nitiyarom, Rattanavalai, Charuvanij, Sirirat, Likasitwattanakul, Surachai, Thanoophunchai, Chaiwat, and Wisuthsarewong, Wanee
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Background: Juvenile dermatomyositis is a rare condition, but it is the most common idiopathic inflammatory myopathy in pediatric patients. Aim: To study the clinical manifestations, investigations, treatment, clinical course, and outcomes of juvenile dermatomyositis in Thai children. Method: This retrospective study included juvenile dermatomyositis patients treated at Siriraj Hospital, a 2,300-bed national tertiary referral center in Bangkok, Thailand, from 1994 to 2019. Results: Thirty patients (22 females and 8 males) were included with a female to male ratio of 2.7:1. Median age at diagnosis was 5.1 years (range, 2.6-14.8 years). Median duration of illness before diagnosis was 6.5 months (range, 0.3-84.0 months). Acute and subacute onset occurred in the majority of patients. Presenting symptoms included muscle weakness in 27/30 (90%), skin rash in 26/30 (86.7%), muscle pain in 17/26 (65.4%), and arthralgia in 4/18 (22.2%) of patients. Dermatologic examination revealed Gottron's rash, heliotrope rash, and periungual telangiectasia in 25/30 (83.3%), 21/30 (70.0%), and 15/24 (62.5%) of patients, respectively. Interestingly, scalp dermatitis was found in 8/21 (38.1%) of patients. The most commonly used treatment regimen in this series was a combination of prednisolone and methotrexate. During the median follow-up of 3.1 years (range, 0.0-18.5 years), only one-third of patients were seen to have monocyclic disease. Extraskeletal osteosarcoma at a previous lesion of calcinosis cutis was observed in one patient at 12 years after juvenile dermatomyositis onset. Limitations: This was a retrospective single-center study, and our results may not be generalizable to other healthcare settings. Prospective multicenter studies are needed to confirm the findings of this study. Conclusion: juvenile dermatomyositis usually poses a diagnostic and therapeutic challenge, which can be compounded by the ethnic variations in the clinical presentation, as observed in this study. Asian patients tend to present with acute or subacute onset of disease, and arthralgia and/or arthritis are less common than in Caucasian patients. Scalp dermatitis is not uncommon in pediatric juvenile dermatomyositis patients. An association between juvenile dermatomyositis and malignancy, though rare, can occur. [ABSTRACT FROM AUTHOR]
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- 2022
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26. Cost–utility and budget impact analysis of tocilizumab for the treatment of refractory systemic juvenile idiopathic arthritis in Thailand
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Kittiratchakool, Nitichen, primary, Kulpokin, Disorn, additional, Chanjam, Chonticha, additional, Vilaiyuk, Soamarat, additional, Charuvanij, Sirirat, additional, Phongsamart, Gun, additional, Khaosut, Parichat, additional, Tanya, Manasita, additional, Nanagara, Ratanavadee, additional, Nantapaisarn, Sira, additional, and Leelahavarong, Pattara, additional
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- 2020
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27. Using “real clinic” definitions to predict the course of juvenile dermatomyositis: Comment on the article by Stringer et al
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Charuvanij, Sirirat and Tucker, Lori B.
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- 2009
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28. The Thai Translation of the Pediatric Gait, Arms, Legs, Spine Tool is Useful for Pediatric Residents in Detecting Musculoskeletal Abnormalities in Children.
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Sukharomana, Maynart and Charuvanij, Sirirat
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- 2021
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29. Early Outcomes in Children with Antineutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV)
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Morishita, Kimberly, Moorthy, Lakshmi N., Lubieniecka, Joanna M., Twilt, Marinka, Yeung, Rae S.M., Toth, Mary B., Shenoi, Susan, Ristic, Goran, Nielsen, Susan M., Li, Suzanne C., Lee, Tzielan, Lawson, Erica, Kostik, Mikhail, Klein-Gitelman, Marisa, Huber, Adam M., Hersh, Aimee O., Foell, Dirk, Elder, Melissa E., Eberhard, Barbara A., Dancey, Paul, Charuvanij, Sirirat, Benseler, Susanne, and Cabral, David
- Abstract
Objective: To characterize early disease course in childhood onset antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) and 12-month outcomes. Methods: Eligible subjects were children diagnosed with GPA, MPA, EGPA, and ANCA-positive pauci-immune glomerulonephritis before their eighteenth birthday and entered into The Pediatric Vasculitis Initiative (PedVas) study. The primary outcome was remission (Pediatric Vasculitis Activity Score (PVAS) = 0 with corticosteroid dose (CS)
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- 2018
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30. Concurrent positive anti-3-hydroxy-3-methylglutaryl-coenzyme a reductase antibody with reducing body myopathy: Possible double trouble
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Tanboon, Jantima, primary, Sanmaneechai, Oranee, additional, Charuvanij, Sirirat, additional, Sangruchi, Tumtip, additional, Galindo-Feria, Angeles S., additional, Lundberg, Ingrid E., additional, Ohnuki, Yuko, additional, Shiina, Takashi, additional, Suzuki, Shigeaki, additional, and Nishino, Ichizo, additional
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- 2019
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31. Health‐related quality of life in children with early‐stage juvenile idiopathic arthritis
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Charuvanij, Sirirat, primary and Chaiyadech, Chollada, additional
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- 2019
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32. Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints
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Jeamsripong, Satita, primary and Charuvanij, Sirirat, additional
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- 2018
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33. Acute epiglottitis as the initial presentation of pediatric Systemic Lupus Erythematosus
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Charuvanij Sirirat and Houghton Kristin M
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Pediatrics ,RJ1-570 ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract We report a case of a 5-year old girl, who initially presented with acute epiglottitis, sepsis and multi-organ failure. She was subsequently diagnosed as having Systemic Lupus Erythematosus. To the best of our knowledge, this article describes the first case of Haemophilus influenzae type f epiglottitis as the initial presentation of SLE in childhood.
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- 2009
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34. Lupus enteritis as the sole presenting feature of systemic lupus erythematosus: case report and review of the literature.
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Chowichian, Monthira, Aanpreung, Prapun, Pongpaibul, Ananya, and Charuvanij, Sirirat
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SYSTEMIC lupus erythematosus ,ENTERITIS ,LITERATURE reviews ,TEENAGE girls ,ABDOMINAL pain - Abstract
Systemic lupus erythematosus (SLE) is a multisystem, autoimmune inflammatory disease which can affect any organ, including the gastrointestinal tract. Lupus enteritis is one of the manifestations of gastrointestinal involvement in SLE patients. However, it is exceedingly rare that lupus enteritis is the sole initial presentation of SLE. A 12-year-old Thai girl who had had recurrent abdominal pain for 2 months with no other signs of SLE on initial presentation is described. A single-balloon enteroscopy demonstrated segmental erythema of the proximal and mid-jejunum. Histopathology demonstrated active enteritis and submucosal vasculitis. On the basis of evidence of intestinal vasculitis, autoimmune profiles were performed; the results supported the possibility of SLE. She subsequently developed leucopenia, lymphopenia and an oral ulcer, leading to a robust diagnosis of SLE. Her clinical condition improved dramatically with prednisolone. Even though lupus enteritis is rare, it can be the initial presentation of SLE. In young adolescent girls with recurrent abdominal pain, the possibility of lupus enteritis should be borne in mind. [ABSTRACT FROM AUTHOR]
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- 2019
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35. Lupus enteritis as the sole presenting feature of systemic lupus erythematosus: case report and review of the literature
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Chowichian, Monthira, primary, Aanpreung, Prapun, additional, Pongpaibul, Ananya, additional, and Charuvanij, Sirirat, additional
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- 2018
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36. Takayasu arteritis with an initial presentation of chronic monoarthritis mimicking oligoarticular juvenile idiopathic arthritis
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Sukharomana, Maynart, primary, Viravan, Sorawit, additional, Piyaphanee, Nuntawan, additional, and Charuvanij, Sirirat, additional
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- 2018
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37. 260 Globalisation of Paediatric Musculoskeletal Matters (PMM)
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Smith, Nicola, primary, Jandial, Sharmila, additional, Wyllie, Ruth, additional, English, Christine, additional, Davies, Barbara, additional, Khubchandani, Raju, additional, Chan, Mercedes, additional, Munro, Jane, additional, Ferriani, Virginia, additional, Magalhães, Claudia Saad, additional, Russo, Ricardo, additional, Yan, Jacqueline, additional, Scott, Chris, additional, Charuvanij, Sirirat, additional, Khawaja, Khulood, additional, Vojinovic, Jelena, additional, Rapley, Tim, additional, and Foster, Helen, additional
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- 2018
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38. 054. Globalisation of Paediatric Musculoskeletal Matters’ (PMM)
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Smith, Nicola, primary, Jandial, Sharmila, additional, Wyllie, Ruth, additional, English, Christine, additional, Davies, Barbara, additional, Khubchandani, Raju, additional, Chan, Mercedes, additional, Munro, Jane, additional, Ferriani, Virginia, additional, Magalhães, Claudia Saad, additional, Yan, Jacqueline, additional, Scott, Chris, additional, Charuvanij, Sirirat, additional, Khawaja, Khulood, additional, Vojinovic, Jelena, additional, Rapley, Tim, additional, and Foster, Helen, additional
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- 2017
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39. Juvenile gout in methylmalonic acidemia
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Charuvanij, Sirirat, primary, Pattaragarn, Anirut, additional, Wisuthsarewong, Wanee, additional, and Vatanavicharn, Nithiwat, additional
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- 2016
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40. Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.
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Cabral, David A., Canter, Debra L., Muscal, Eyal, Nanda, Kabita, Wahezi, Dawn M., Spalding, Steven J., Twilt, Marinka, Benseler, Susanne M., Campillo, Sarah, Charuvanij, Sirirat, Dancey, Paul, Eberhard, Barbara A., Elder, Melissa E., Hersh, Aimee, Higgins, Gloria C., Huber, Adam M., Khubchandani, Raju, Kim, Susan, Klein‐Gitelman, Marisa, and Kostik, Mikhail M.
- Subjects
GRANULOMATOSIS with polyangiitis diagnosis ,CHI-squared test ,COMPARATIVE studies ,DEMOGRAPHY ,DIFFERENTIAL diagnosis ,FISHER exact test ,PROBABILITY theory ,RESEARCH funding ,T-test (Statistics) ,GRANULOMATOSIS with polyangiitis ,VASCULITIS ,RETROSPECTIVE studies ,DATA analysis software ,DESCRIPTIVE statistics ,MANN Whitney U Test ,SYMPTOMS ,DIAGNOSIS - Abstract
Objective To uniquely classify children with microscopic polyangiitis (MPA), to describe their demographic characteristics, presenting clinical features, and initial treatments in comparison to patients with granulomatosis with polyangiitis (Wegener's) (GPA). Methods The European Medicines Agency (EMA) classification algorithm was applied by computation to categorical data from patients recruited to the ARChiVe (A Registry for Childhood Vasculitis: e-entry) cohort, with the data censored to November 2015. The EMA algorithm was used to uniquely distinguish children with MPA from children with GPA, whose diagnoses had been classified according to both adult- and pediatric-specific criteria. Descriptive statistics were used for comparisons. Results In total, 231 of 440 patients (64% female) fulfilled the classification criteria for either MPA (n = 48) or GPA (n = 183). The median time to diagnosis was 1.6 months in the MPA group and 2.1 months in the GPA group (ranging to 39 and 73 months, respectively). Patients with MPA were significantly younger than those with GPA (median age 11 years versus 14 years). Constitutional features were equally common between the groups. In patients with MPA compared to those with GPA, pulmonary manifestations were less frequent (44% versus 74%) and less severe (primarily, hemorrhage, requirement for supplemental oxygen, and pulmonary failure). Renal pathologic features were frequently found in both groups (75% of patients with MPA versus 83% of patients with GPA) but tended toward greater severity in those with MPA (primarily, nephrotic-range proteinuria, requirement for dialysis, and end-stage renal disease). Airway/eye involvement was absent among patients with MPA, because these GPA-defining features preclude a diagnosis of MPA within the EMA algorithm. Similar proportions of patients with MPA and those with GPA received combination therapy with corticosteroids plus cyclophosphamide (69% and 78%, respectively) or both drugs in combination with plasmapheresis (19% and 22%, respectively). Other treatments administered, ranging in decreasing frequency from 13% to 3%, were rituximab, methotrexate, azathioprine, and mycophenolate mofetil. Conclusion Younger age at disease onset and, perhaps, both gastrointestinal manifestations and more severe kidney disease seem to characterize the clinical profile in children with MPA compared to those with GPA. Delay in diagnosis suggests that recognition of these systemic vasculitides is suboptimal. Compared with adults, initial treatment regimens in children were comparable, but the complete reversal of female-to-male disease prevalence ratios is a provocative finding. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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41. Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two: Genoa, Italy. 28 September – 01 October 2016
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Lomakina, Olga, Alekseeva, Ekaterina, Valieva, Sania, Bzarova, Tatiana, Nikishina, Irina, Zholobova, Elena, Rodionovskaya, Svetlana, Kaleda, Maria, Nakagishi, Yasuo, Shimizu, Masaki, Mizuta, Mao, Yachie, Akihiro, Sugita, Yuko, Okamoto, Nami, Shabana, Kousuke, Murata, Takuji, Tamai, Hiroshi, Smith, Eve M., Yin, Peng, Jorgensen, Andrea L., Beresford, Michael W., Eleuteri, Antonio, Goilav, Beatrice, Lewandowski, Laura, Phuti, Angel, Wahezi, Dawn, Rubinstein, Tamar, Jones, Caroline, Newland, Paul, Marks, Stephen, Corkhill, Rachel, Ekdawy, Diana, Pilkington, Clarissa, Tullus, Kjell, Putterman, Chaim, Scott, Chris, Fisher, Antony C., Jorgensen, Andrea, Batu, Ezgi Deniz, Kosukcu, Can, Taskiran, Ekim, Akman, Sema, Ozturk, Kubra, Sozeri, Betul, Unsal, Erbil, Ekinci, Zelal, Bilginer, Yelda, Alikasifoglu, Mehmet, Ozen, Seza, Lythgoe, Hanna, Brunner, Hermine I., Gulati, Gaurav, Jones, Jordan T., Altaye, Mekibib, Eaton, Jamie, Difrancesco, Mark, Yeo, Joo Guan, Leong, Jingyao, Bathi, Loshinidevi D/O Thana, Arkachaisri, Thaschawee, Albani, Salvatore, Abdelrahman, Nagla, Beresford, Michael W, Leone, Valentina, Groot, Noortje, Shaikhani, D., Bultink, I. 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Chavez, Martino, David, Ponsonby, Anne-Louise, Chiaroni-Clarke, Rachel, Meyer, Braydon, Allen, Roger C., Akikusa, Jonathan D., Craig, Jeffrey M., Saffrey, Richard, Ellis, Justine A., Wallace, Carol, Uziel, Yosef, Sterba, Gary, Schneider, Rayfel, Russo, Ricardo, Ramanan, Athimalaipet V., Schmid, Jana Pachlopnik, Nichols, Kim E, Miettunen, Paivi, Kitoh, Toshiyuki, Ilowite, Norman T., Henter, Jan-Inge, Grom, Alexei A, Behrens, Edward M., Avcin, Tadej, Aricò, Maurizio, Grevich, Sriharsha, Lee, Peggy, Ringold, Sarah, Leroux, Brian, Leahey, Hannah, Yuasa, Megan, Foster, Jessica, Sokolove, Jeremy, Lahey, Lauren, Robinson, William, Newson, Joshua, Stevens, Anne, Shoop, Stephanie J. W., Verstappen, Suzanne M. M., Thomson, Wendy, McDonagh, Janet E., Beukelman, Timothy, Kimura, Yuki, Natter, Marc, Ilowite, Norm, Mieszkalski, Kelly, Burrell, Grendel, Best, Brian, Bristow, Helen, Carr, Shannon, Dennos, Anne, Kaufmann, Rachel, Schanberg, Laura, Simonini, Gabriele, Lancini, Francesca, Gerbaux, Margaux, Lê, Phu-Quoc, Goffin, Laurence, Badot, Valérie, La, Céline, Caspers, Laure, Willermain, François, Ferster, Alina, Ceci, Maria, Licciardi, Francesco, Turco, Marco, Santarelli, Francesca, Montin, Davide, Toppino, Claudia, Alizzi, Clotilde, Papia, Bruno, Vergara, Beatrice, Corpora, Umberto, Messina, Luca, Tsinti, Maria, Dermentzoglou, Vasiliko, Tziavas, Panagiotis, Perica, Marija, Bukovac, Lana Tambić, Çakan, Mustafa, Ayaz, Nuray Aktay, Keskindemirci, Gonca, Lang, Michael, Laing, Catherine, Benseler, Susanne, Gerschman, Tommy, Luca, Nadia, Schmeling, Heinrike, Dropol, Anastasia, Taiani, Jaymi, Johnson, Nicole, Rusted, Brian, Nalbanti, Panagiota, Pratsidou, Polyxeni, Pardalos, Grigoris, Tzimouli, Vasiliki, Taparkou, Anna, Stavrakidou, Maria, Papachristou, Fotios, Kanakoudi-Tsakalidou, Florence, Bale, Peter, Robinson, Emily, Palman, Jason, Ralph, Elizabeth, Gilmour, Kimberly, Heard, Clare, Wedderburn, Lucy R., Barrense-Dias, Yara, Gregory, Antonarakis, Amira, Dhouib, Paolo, Scolozzi, Sylviane, Hanquinet, Michaël, Hofer, Panko, Nataliya, Shokry, Salah, Rakovska, Liudmila, Pino, Sally, Diaz-Maldonado, Adriana, Guarnizo, Pilar, Torreggiani, Sofia, Cressoni, Paolo, Garagiola, Umberto, Di Landro, Giancarla, Farronato, Giampietro, Corona, Fabrizia, Bell, Samantha, Bhatti, Parveen, Nelson, Lee, Mueller, Beth A., Simon, T. A., Baheti, A., Ray, N., Guo, Z., Hazra, Anasuya, Stock, Thomas, Wang, Ronnie, Mebus, Charles, Alvey, Christine, Lamba, Manisha, Krishnaswami, Sriram, Conte, Umberto, Wang, Min, Kingsbury, Daniel, Koskova, Elena, Smolewska, Elzbieta, Vehe, Richard K., Lovell, Daniel, Kubota, Tomohiro, Yasumura, Junko, Kizawa, Toshitaka, Yashiro, Masato, Yamatou, Tsuyoshi, Yamasaki, Yuichi, Takei, Syuji, Kawano, Yoshifumi, Nykvist, Ulrika Järpemo, Magnusson, Bo, Wicksell, Rikard, Palmblad, Karin, Olsson, Gunnar L., Modaressi, Mohammadreza, Moradinejad, Mohammad-Hassan, Seraya, Valentina, Vitebskaya, Alisa, Moshe, Veronica, Amarilyo, Gil, Harel, Liora, Hashkes, Phillip J, Mendelson, Amir, Rabinowicz, Noa, Reis, Yonit, Dāvidsone, Zane, Lazareva, Arina, Šantere, Ruta, Bērziņa, Dace, Staņēviča, Valda, Varnier, Giulia Camilla, Maillard, Susan, Ferrari, Cristina, Zaffarano, Silvia, Wienke, Judith, Enders, Felicitas Bellutti, van den Hoogen, Lucas L., Mertens, Jorre S., Radstake, Timothy R., Hotten, Henny G., Fritsch, Ruth, Wedderburn, Lucy, Nistala, Kiran, Prakken, Berent, van Royen-Kerkhof, Annet, Alhemairi, Mohammad, Muzaffer, Mohammed, Van Dijkhuizen, Pieter, Deakin, Claire T., Simou, Stefania, De Iorio, Maria, Wu, Qiong, Amin, Tania, Dossetter, Lee, Campanilho-Marques, Raquel, Deakin, Claire, Pilkington, Clarissa A., Rosina, Silvia, Soponkanaporn, Sirisucha, Arıcı, Zehra S., Tuğcu, Gökçen D., Batu, Ezgi D., Sönmez, Hafize E., Doğru-Ersöz, Deniz, Talim, Beril, Kiper, Nural, Özen, Seza, Solyom, Alexander, Batu, Ezgi, Mitchell, John, Kariminejad, Ariana, Hadipour, Fatemeh, Hadipour, Zahra, Torcoletti, Marta, Agostoni, Carlo, Di Rocco, Maja, Tanpaiboon, Pranoot, Superti-Furga, Andrea, Bonafé, Luisa, Arslan, Nur, Guelbert, Norberto, Ehlert, Karoline, Grigelioniene, Giedre, Puri, Ratna, Schuchman, Edward, Gomez, Pilar, Gonzalez, Tatiana, Yepez, Ricardo, Vargas, Camilo, Fernanda, Falcini, Lepri, Gemma, Ferrari, Alessandra, Matucci-Cerinic, Marco, Meini, Antonella, Moneta, Gian Marco, Marasco, Emiliano, Nicolai, Rebecca, Bracci-Laudiero, Luisa, Kopchak, Olga, Mushkin, Alexander, Maletin, Alexey, Mosquera, Catalina, Amorim, Rita A., Molina, Juliana, Moreira, Gustavo, Santos, Flávia H., Fraga, Melissa, Keppeke, Livia, Silva, Vanessa M., Hirotsu, Camila, Tufik, Sergio, Terreri, Maria Teresa, Braga, Vinícius L., Fonseca, Maria Beatriz, Schinzel, Vania, Terreri, Maria Teresa R., Jorge, Liliana, Guerra, Liana, Junior, Edson Amaro, Castiglione, Maria Cristina, Tricarico, Alessandra, Boulter, Emily, Schultz, Andre, Murray, Kevin, Falcini, Fernanda, Stagi, Stefano, Bellucci, Eleonora, Grein, Ingrid H. R., Pileggi, Gecilmara, Pinto, Natália B. F., de Oliveira, Aline L., Belyaeva, Lyudmila, Filonovich, Rostislav, Khrustaleva, Helena, Zajtseva, Larisa, Ilisson, Jaanika, Pruunsild, Chris, Gilliaux, Olivier, Corazza, Francis, Lelubre, Christophe, Morel, Zoilo, C, Claudia Saad-Magalhães, Lira, Luis, Ladino, Mabel, Eraso, Ruth, Arroyo, Ivonne, Silva, Clovis, and Rose, Carlos
- Published
- 2017
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42. Severe Deferiprone-Induced Arthropathy in Young Adolescent Successfully Treated with Intraarticular Triamcinolone Acetonide Injection: A Case Report.
- Author
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Buaboonnam, Jassada and Charuvanij, Sirirat
- Subjects
JOINT diseases ,TRIAMCINOLONE acetonide ,TREATMENT of arthritis ,CHELATION therapy ,ARTHROCENTESIS ,THALASSEMIA treatment ,DRUG side effects ,NONSTEROIDAL anti-inflammatory agents ,THERAPEUTICS - Abstract
Deferiprone (DFP), an oral chelation therapy, has improved treatment adherence and quality of life of transfusion dependent thalassemia (TDT). DFP-induced arthropathy is usually mild and self-limited; the severe DFP-induced arthropathy is uncommon presentation. Herein, a Thai girl diagnosed as TDT was initially treated with DFP. She subsequently developed severe DFP-induced bilateral knee arthritis despite discontinuing DFP and using non-steroidal anti-inflammatory drugs (NSAIDs). She was treated with arthrocentesis and intraarticular triamcinolone acetonide injection and responded well to the treatment. [ABSTRACT FROM AUTHOR]
- Published
- 2017
43. Nonspecific interstitial pneumonia in refractory systemic juvenile idiopathic arthritis responded to tocilizumab treatment.
- Author
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Sukharomana M, Udomittipong K, Ruangchira-Urai R, and Charuvanij S
- Subjects
- Antibodies, Monoclonal, Humanized therapeutic use, Child, Child, Preschool, Humans, Male, Arthritis, Juvenile complications, Arthritis, Juvenile drug therapy, Lung Diseases, Interstitial complications, Lung Diseases, Interstitial etiology, Macrophage Activation Syndrome complications
- Abstract
Background: Nonspecific interstitial pneumonia (NSIP) is a rare pulmonary complication in systemic juvenile idiopathic arthritis (SJIA)., Objective: To present a case with NSIP in SJIA., Methods: Case report., Results: We report the case of a 4-year-old boy with SJIA complicated by macrophage activation syndrome (MAS) refractory to conventional therapy, and who later developed NSIP confirmed by high-resolution computerized tomography of the chest and lung histopathology. The patient received tocilizumab, a monoclonal antibody to interleukin-6 receptor, to control his disease. Data relating to tocilizumab treatment of NSIP in refractory SJIA is limited., Conclusions: The data from this case report suggests that NSIP could be a pulmonary complication of SJIA complicated by MAS that is refractory to conventional therapy. Early initiation of tocilizumab should be considered to achieve disease remission in this pediatric patient population.
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- 2022
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44. The Thai Translation of the Pediatric Gait, Arms, Legs, Spine Tool is Useful for Pediatric Residents in Detecting Musculoskeletal Abnormalities in Children.
- Author
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Sukharomana M and Charuvanij S
- Subjects
- Child, Cross-Sectional Studies, Gait, Humans, Leg, Thailand, Musculoskeletal Abnormalities, Pediatrics
- Abstract
Background: The pediatric Gait, Arms, Legs, Spine (pGALS) tool is used to screen musculoskeletal (MSK) abnormalities in children. This study aimed to evaluate the application of the Thai translation of pGALS tool in outpatient clinical settings., Methods: This cross-sectional study included patients aged 4 to 16 years, recruited from the Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. Pediatric residents performed the Thai pGALS tool, and a pediatric rheumatologist performed the MSK examination., Results: One hundred Thai patients were enrolled with a mean age of 9.87 ± 3.01 years. Forty percent of patients had MSK complaints. The median duration of the assessment was 3.96 minutes (interquartile range, 2.07-5.84 minutes). Abnormal pGALS examination by pediatric residents was found in 43 patients, all of which had abnormal MSK examination by a pediatric rheumatologist. Seventeen patients did not have abnormal pGALS examination by pediatric residents, but had abnormal MSK examination confirmed by a pediatric rheumatologist; these patients all had noninflammatory/mechanical conditions. The 3 screening questions of the Thai pGALS tool had a sensitivity and specificity of 71.67% and 77.5%, respectively; the examination had a sensitivity and specificity of 74.14% and 100%, respectively. For acceptability, 99% of parents and 89% of patients reported no discomfort. For practicality, 99% of parents and 89% of patients reported the highest level of practicality., Conclusions: The Thai pGALS tool is useful for MSK screening in children performed by pediatric residents in outpatient clinical settings. Adding maneuvers to the pGALS examination to detect more common noninflammatory MSK conditions would be beneficial., Competing Interests: The authors declare no conflict of interest., (Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2021
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45. Early Outcomes in Children With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
- Author
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Morishita KA, Moorthy LN, Lubieniecka JM, Twilt M, Yeung RSM, Toth MB, Shenoi S, Ristic G, Nielsen SM, Luqmani RA, Li SC, Lee T, Lawson EF, Kostik MM, Klein-Gitelman M, Huber AM, Hersh AO, Foell D, Elder ME, Eberhard BA, Dancey P, Charuvanij S, Benseler SM, and Cabral DA
- Subjects
- Adolescent, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis complications, Azathioprine therapeutic use, Child, Cohort Studies, Cyclophosphamide therapeutic use, Female, Follow-Up Studies, Humans, Kidney Diseases etiology, Lung Diseases etiology, Male, Methotrexate therapeutic use, Mycophenolic Acid therapeutic use, Prospective Studies, Recurrence, Remission Induction, Retrospective Studies, Rituximab therapeutic use, Adrenal Cortex Hormones therapeutic use, Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis drug therapy, Immunosuppressive Agents therapeutic use, Kidney Diseases drug therapy, Lung Diseases drug therapy, Registries
- Abstract
Objective: To characterize the early disease course in childhood-onset antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and the 12-month outcomes in children with AAV., Methods: Eligible subjects were children entered into the Pediatric Vasculitis Initiative study who were diagnosed before their eighteenth birthday as having granulomatosis with polyangiitis (Wegener's), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss), or ANCA-positive pauci-immune glomerulonephritis. The primary outcome measure was achievement of disease remission (Pediatric Vasculitis Activity Score [PVAS] of 0) at 12 months with a corticosteroid dosage of <0.2 mg/kg/day. Secondary outcome measures included the rates of inactive disease (PVAS of 0, with any corticosteroid dosage) and rates of improvement at postinduction (4-6 months after diagnosis) and at 12 months, presence of damage at 12 months (measured by a modified Pediatric Vasculitis Damage Index [PVDI]; score 0 = no damage, score 1 = one damage item present), and relapse rates at 12 months., Results: In total, 105 children with AAV were included in the study. The median age at diagnosis was 13.8 years (interquartile range 10.9-15.8 years). Among the study cohort, 42% of patients achieved remission at 12 months, 49% had inactive disease at postinduction (4-6 months), and 61% had inactive disease at 12 months. The majority of patients improved, even if they did not achieve inactive disease. An improvement in the PVAS score of at least 50% from time of diagnosis to postinduction was seen in 92% of patients. Minor relapses occurred in 12 (24%) of 51 patients after inactive disease had been achieved postinduction. The median PVDI damage score at 12 months was 1 (range 0-6), and 63% of patients had ≥1 PVDI damage item scored as present at 12 months., Conclusion: This is the largest study to date to assess disease outcomes in pediatric AAV. Although the study showed that a significant proportion of patients did not achieve remission, the majority of patients responded to treatment. Unfortunately, more than one-half of this patient cohort experienced damage to various organ systems early in their disease course., (© 2017, American College of Rheumatology.)
- Published
- 2017
- Full Text
- View/download PDF
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