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Background: Mycobacterium xenopi spinal infections were diagnosed in 1993 in patients who had undergone surgical microdiscectomy for disc hernia, by nucleotomy or microsurgery, in a private hospital. Contaminated tap water, used for rinsing surgical devices after disinfection, was identified as the source of the outbreak. Several cases were recorded in the 4 years after implementation of effective control measures because of the long time between discectomy and case detection. The national health authorities decided to launch a retrospective investigation in patients who were exposed to M xenopi contamination in that hospital.Methods: Mailing and media campaigns were undertaken concurrently to trace exposed patients for spinal infections. Patients were screened by magnetic resonance imaging (MRI), and the scans were reviewed by a radiologist who was unaware of the diagnosis. Suspected cases had discovertebral biopsy for histopathological and bacteriological examination.Findings: Of 3244 exposed patients, 2971 (92%) were informed about the risk of infection and 2454 (76%) had MRI. Overall, 58 cases of M xenopi spinal infection were identified (overall cumulative frequency 1.8%), including 26 by the campaign (mean delay in detection 5.2 years, SD 2.4, range 1-10 years). Multivariate analysis showed that the risk of M xenopi spinal infection was related to nucleotomy and high number of patients per operating session.Interpretation: Failures in hygiene practices could result in an uncontrolled outbreak of nosocomial infection. Patients who have been exposed to an iatrogenic infectious hazard should be screened promptly and receive effective information. [ABSTRACT FROM AUTHOR]

Objectives: Fabry disease is a rare X-linked metabolic disorder characterized by a deficiency in the enzyme alpha-galactosidase A. Both males and females can be affected. The main presenting symptom is pain in the extremities, whereas at a more advanced stage, the manifestations include hypertrophic cardiomyopathy, cardiac dysrhythmia, proteinuria, chronic kidney dysfunction, stroke, and hearing loss. When not diagnosed and treated, Fabry disease causes early death. No studies specifically designed to describe the musculoskeletal manifestations of Fabry disease are available., Methods: We conducted a single-center retrospective study of patients receiving follow-up at a Fabry disease referral center. We described the musculoskeletal manifestations and analyzed the differential diagnoses., Results: Our study included 40 patients belonging to 20 families, including 25 females with a mean age of 44.2 years (range, 20-76 years) and 15 males with a mean age of 40.1 years (range, 16-61 years). Mean age at the diagnosis of Fabry disease was 37.2 years (range, 7-71 years) in the females and 26.9 years (range, 9-51 years) in the males. Specific enzyme replacement therapy was given to 10 (40%) females and 12 (80%) males. Musculoskeletal manifestations were as follows: past or present pain in the extremities (13 females and 10 males), combined in some patients with vasomotor disorders in the extremities and telangiectasia; exercise intolerance (12 females and 12 males); osteoporotic fractures (2 brothers aged 45 and 44 years, respectively); osteoporosis (3 females, aged 57, 63, and 75 years, respectively), which contributed to death in the oldest patient; osteopenia (2 females aged 38 and 47 years, respectively; and 1 male aged 43 years); Charcot foot and lymphedema with serious infectious complications (4 males older than 40 years), with avascular osteonecrosis of the lower limbs in 2 cases; toe amputations (3 cases); bilateral lower-limb amputation (1 case); abnormally slender lower limbs (5 females and 8 males); acute gout (3 males with severe chronic kidney failure); and carpal tunnel syndrome (1 female and 1 male, both younger than 40 years). Mistaken diagnoses that were made at an early stage, contributing to delay the identification of Fabry disease, included rheumatic fever (2 females and 2 males), growing pains (2 males), pain with paralysis (1 female), chilblains of the lower limbs (1 female), and erythermalgia (1 female). In adulthood, the following mistaken diagnoses were made: Sjögren's syndrome and/or sicca syndrome (6 females), systemic sclerosis (1 male), dysautonomia (1 female), and familial Mediterranean fever (1 female)., Conclusion: The diagnosis of Fabry disease is usually delayed, due to confusion with more common disorders. Musculoskeletal manifestations may constitute the presenting symptoms. Past or present pain in the extremities is typical. Osteoporosis may develop early and become severe. Together with the family history, the presence of musculoskeletal manifestations can lead to the correct diagnosis by prompting alpha-galactosidase assays in males and genetic testing in females. Fabry disease is often responsible for musculoskeletal manifestations, of which the most common are pain in the extremities and osteoporosis. These manifestations can be inaugural and lead to diagnostic wanderings. They require specific treatment strategies., (Copyright © 2015 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.)

An immunocompetent 84-year-old woman was admitted for severe neck pain with a fever. Magnetic resonance imaging showed osteitis of the dens. She had methicillin-susceptible Staphylococcus aureus bacteremia related to a dental extraction. She then developed an infection of a hip prosthesis due to the same organism. Her treatment consisted in intravenous antibiotics followed by oral suppressive antibiotic therapy for 2 years. Exchange arthroplasty was not performed given the advanced age of the patient, her unwillingness to undergo the procedure, and the risk of neurological complications during endotracheal intubation. The outcome was favorable at last follow-up more than 2 years after antibiotic treatment initiation., (Copyright © 2013 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.)

Objective: Osteomyelitis is rare in adults and typically occurs in patients with risk factors such as sickle cell disease or immune deficiency. Cases in immunocompetent adults without sickle cell disease are extremely rare. The objective of this work was to describe the epidemiological, clinical, laboratory, and radiological features and the management of long-bone osteomyelitis in immunocompetent adults without sickle cell disease., Methods: We conducted a retrospective descriptive study of all immunocompetent adults without sickle cell disease who were admitted to our center between November 2002 and November 2008 for long-bone osteomyelitis. In all patients, the clinical symptoms started in adulthood, in the absence of a childhood history of osteomyelitis., Results: We identified six patients meeting our inclusion criteria over the 6-year study period. The causative microorganism was methicillin-susceptible Staphylococcus aureus in four patients and Salmonella in two patients (wild-type S. typhi and S. enterica, respectively). In each patient, there was a single focus of osteomyelitis and a single causative microorganism. The symptoms developed insidiously and lacked specificity. At presentation, the patients had moderate pain with or without a swelling. There was no fever initially in five patients, three of whom had major diagnostic delays as a result. Treatment associated antibiotics and surgery in all patients and the initial outcome was consistently favorable (median follow-up: 15 months; range: 8-72)., Conclusion: Osteomyelitis can occur even in immunocompetent adults. The protracted course and atypical presentation of osteomyelitis in immunocompetent adults may lead to major diagnostic delays., (Copyright © 2010 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.)

We report a case of diffuse subacute muscle infection caused by enteric bacteria, diagnosed two months after laparoscopic colectomy for a sigmoid abscess and successfully treated with antibiotics alone.

Objectives: To show that helical computed tomography arthrograms (HCTA) with multiplanar reformations can document cartilage lesions and their characteristics in patients with suspected hip osteoarthritis and normal or inconclusive hip radiographs., Methods: We retrospectively reviewed abnormal HCTAs from patients with mechanical hip pain and normal findings on anteroposterior and oblique ("faux profil") radiographs of the pelvis. HCTA in all patients consisted in acquiring 1 mm transverse slices and obtaining coronal and sagittal reformations. Radiographs and HCTAs were read separately by two experienced radiologists, who then worked together to reach a consensus., Results: We identified 18 patients with abnormal HCTA findings and a full set of imaging studies. Mean age was 47.8 years, and there were 14 women and four men. Acetabular cartilage lesions were found consistently; they were often deep and predominated in the anterosuperior region. A labral fissure was noted in 12 patients. The sagittal and coronal reformations proved more informative than the acquired transverse slices. Interobserver reproducibility was excellent for the HCTA diagnosis of cartilage lesions., Conclusions: In patients with hip pain and normal radiographs, HCTA can provide a diagnosis of hip osteoarthritis by showing cartilage lesions, which are usually located in the anterosuperior part of the acetabulum.

Objectives: To define the sensitivity and specificity of routine preoperative hip aspiration for diagnosing hip prosthesis infection (HPI) and to separately analyze subgroups with and without a clinical suspicion of HPI before aspiration., Methods: From June 1994 to June 1997, all patients scheduled for hip revision surgery underwent aspiration of the hip under image intensifier guidance. Microbiological results were compared between these preoperative specimens and the intraoperative specimens. The reason for surgery was either a clinical suspicion of HPI or pain suggesting loosening., Results: The study patients had had multiple surgical procedures. HPI was suspected clinically in 39.4% of cases. Of the 109 patients who underwent aspiration, 54 had true-negative results, nine had false-negative results, and 44 had true-positive results (there were no false-positive results), yielding a sensitivity of 83% and a specificity of 100%. Diagnostic efficiency was 91.6%, positive predictive value was 100%, and negative predictive value was 85.7%. In the subset of 43 patients with a clinical suspicion of HPI, aspiration identified all the causative organisms in 60.5% of cases. Of the 66 patients with no clinical suspicion of HPI, 12 had HPI, and aspiration provided the diagnosis preoperatively in seven of these patients, radically changing their management plans. Restricting routine aspiration to patients whose prosthesis had been implanted within the last 5 years or whose erythrocyte sedimentation rate (ESR) was above 30 mm/h would not have modified our findings., Conclusions: Hip aspiration before revision surgery for pain is effective in detecting HPI, which can simulate aseptic loosening. However, this investigation may be noncontributive in patients who have had their prosthesis for more than 5 years and whose ESR is less than 30 mm/h.

Objective: Monitor a reproducible analysis method based on a simple algorithm., Diagnosis of Rheumatologic Disease in Wrists: The first step is to examine the joint space. When the space is preserved, diagnosis may be established on the presence of bony defects, demineralization or erosions., Diagnosis of Rheumatologic Disease in Fingers: The first step is to determine whether the patient has degenerative or inflammatory joint disease involving the joint space or bone disease where bony lesions predominate.

Background: Intraspinal neurenteric cysts are exceptional formations which develop from incomplete separation of the neural tube and the endodermis during the third week of gestation. Symptoms generally appear before the age of 40 years and are associated with spinal malformations. Most neurenteric cysts lie in an extra-spinal position in the lower cervical and upper dorsal spine. We report a case involving the cauda equina with no associated spinal lesion., Case Report: A 63-year-old woman was admitted for low back pain and right L3 radiculalgia triggered by exertion. Urinary disorders had developed over the preceding year. Physical examination found a spinal syndrome with hypoesthesia of the right para-anal area, an atonic anal sphincter and a globular bladder. Plain films showed a widened interpedicular space between L1 and L2 interpreted as the consequence of an expansive intraspinal lesion. Saccoradiculography led to the diagnosis of an intradural lesion involving L1 and L2. At magnetic resonance imaging, the lesion's signal intensity was similar to cerebrospinal fluid on T1 and T2 sequences, deforming the cauda equina and displacing the nerve roots. Surgical resection of the cyst was incomplete due to adherences to several roots and was followed by persistent radiculalgia and sphincter disorders., Discussion: This case demonstrates an exceptional cause of cauda equina syndrome. Fissuration or rupture of the cyst might explain symptom exacerbation following trauma. Magnetic resonance imagining can confirm the cystic nature of the intradural lesion and help guide surgery. Resection is often incomplete with the risk of long-term recurrence.

The hand is a major site of musculoskeletal disorders. Clinical features to be studied include the patient's age and sex, pain, stiffness, range of motion of the various joints of the wrists and hands, soft tissue swelling (particularly tendons sheaths), bone excrescences, skin changes. Radiological abnormalities in the hands, if any, may confirm the clinical diagnosis. The main features of rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, erosive degenerative changes, Südeck syndrome, calcium pyrophosphate dihydrate deposition disease, etc., are reviewed.

Lumbar chemonucleolysis is an alternative treatment of the sciatic pain due to a disc herniation. It gives good results in 70 to 80% of selected patients. When a correct technique is used, the complication rate is lesser than that of the open surgery. The indications of lumbar chemonucleolysis are larger than in the past and include lateral disc herniations, large or migrated disc herniations, and patients under 18 years or over 60 years. Further studies are necessary to determine if magnetic resonance imaging helps in patients selection and improve the success rate of chemonucleolysis.

Arthrography of hip arthroplasties is a safe, easy-to-perform procedure. It is mainly indicated when infection of the arthroplasty is suspected: the contrast agent fills bone defects that may be present between normal bone and the prosthesis and reaspiration of injected fluids may lead to bacteriological diagnosis. Another indication for arthrography of hip arthroplasties is unexplained painful hip prosthesis.

A case of destructive arthropathy of the hip with onset two years after surgical removal of an intracapsular osteoid osteoma of the femoral neck is reported. Coincidental occurrence in the same joint of an osteoid osteoma and a destructive arthropathy of unknown etiology cannot be ruled out. However, another hypothesis which deserves discussion is that self-perpetuating synovitis was triggered by the release of mediators of inflammation due to presence of the osteoid osteoma.

Nuclear magnetic resonance has shed new light on our understanding of osteonecrosis of the femoral head. It is at present the most sensitive and most specific imaging technique for the diagnosis of this condition. Studies involving correlations between MR images and anatomical findings have facilitated the understanding of tissue changes responsible for magnetic appearances. However, all problems are not resolved. At an early stage, fortunately almost always asymptomatic, false negative MRI or MR findings similar to those of algoneurodystrophy of the hip can be encountered. The aim of this article is to pinpoint the current status of these questions on the basis of a review of the recent literature. The contribution of MRI with injection of Gadolinium and future prospects are also discussed.

The wrist is an articular complex composed of the radio-carpal, distal radio-ulnar and all of the carpal joints. Despite progress in imaging techniques, conventional radiology with plain x-rays and arthrography are still very widely used. Plain x-rays, numerous because of the anatomical complexity of the wrist, must be selected in relation to the clinical context and suspected diagnosis and must be performed according to a perfect technique. Contrast arthrography may be uni-, bi-, or tri-compartmental depending on the information required. It allows assessment of the integrity of the intra-articular synovial and ligamentous structures. The specific indications for computed tomography are uncommon, but those of MRI are becoming increasingly frequent due to refinement of the machines, especially the development of surface coils.

That proximal joint, the glenohumeral joint is difficult to examine by simple X-rays which explains the numerous lateral views proposed; it is essential to know the precise indications and respective value of each of these views. Arthrography generally combined with computed tomography is an excellent examination for the study of the glenoidal labrum and the capsular structures. In other indications, particularly for the study of the rotator cuff, it tends to be replaced by MRI.

The best assessment tests for long term trials on osteoarthritis (OA) of the hip and knee are the following, in order of relevance value (consensus of french experts): 1) the loss of joint space thickness on successive radiographies; 2, 3) the indices of the severity for OA of the hip and knee; the investigator's overall opinion; 4) the patient's overall opinion (visual analogue scale of handicap); 5, 6, 7) the pain level (visual analogue scale); the time for going up and down a standard flight of stairs and the time of pain in this distance; the limitation of two articular movements; 8) the increase of either analgesics or NSAIDs consumption; 9) concerning OA of fingers, the number of joints newly involved on successive radiographies. At present, only the radiological tests 1 and 9 are validated. The clinical tests 2 to 8, valuable for short term trials, have yet to be validated for long term follow-up. Recommended duration of trials is three years. A rigorous organisation is necessary to avoid erroneous inclusions: all data recorded in the pre-inclusion visit have to be checked by the principal investigator. Since we have not yet a validated chondroprotective agent as a reference drug, the trial must be randomised, double blind, placebo controlled, parallel group study.