Demands for thermal comfort, better indoor air quality together with lower environmental impacts have had ascending trends in the last decade. In many circumstances, these demands could not be fully covered through the soft approach of bioclimatic design like optimization of the building orientation and internal layout. This is mostly because of the dense urban environment and the internal energy loads of the building. In such cases, heating, ventilation, air-conditioning and refrigeration (HVAC&R) systems make a key contribution to fulfilling the requirements of the indoor environment. Therefore, the most appropriate HVAC&R system must be selected. In this study, a robust decision making approach for HVAC&R system selection is proposed. Technical performance, economic and environmental impacts of 36 permutations of primary and secondary systems are taken into account to choose the most appropriate HVAC&R system for a case study office building. The building is a representative of the dominant form of office buildings in the UK. Dynamic performance evaluation of HVAC&R alternatives using the TRNSYS package together with life-cycle energy cost analysis is undertaken to provide a reliable basis for decision making. The six scenarios considered in this paper broadly cover the decision makers' attitudes on HVAC&R system selection. These scenarios are analyzed through an Analytical Hierarchy Process (AHP), and sensitivity analyses which prove the robustness of the final decision for each scenario. One of the significant outcomes of this study reveals that the compound heating, cooling and power system (CCHP), despite the high level of energy demand and also a higher initial investment, is one of the top-ranked alternatives due to the lower energy cost and C02 emissions. The proposed approach and the results of this study could be used by researchers and designers, especially in the early stages of a design process where all the involved bodies commonly face a lack of time, information and the tools necessary for the evaluation of a variety of HVAC&R systems. [ABSTRACT FROM AUTHOR]