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10 results on '"Crepaldi, Francesca"'

1. Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial

Author

Frassineti, Giovanni Luca, Sansoni, Elisabetta, Ragazzini, Angela, Ruscelli, Silvia, Crivellari, Gino, Galiano, Antonella, Rodriquenz, Maria Grazia, Biasini, Claudia, Porzio, Rosa, Pittureri, Cristina, Amaducci, Elena, Faedi, Marina, Codecà, Carla, Crepaldi, Francesca, Pedrazzoli, Paolo, Bramanti, Alfina, Buonadonna, Angela, Garetto, Ferdinando, Comandone, Alessandro, Giordano, Monica, Luchena, Giovanna, Luzzani, Massimo, Cifatte, Chiara, Pino, Maria Simona, Zoccali, Sonia, Cattaneo, Maria Teresa, Dalu, Davide, Sozzi, Pietro, Gauna, Roberta, Alquati, Sara, Costantini, Massimo, Quadrini, Silvia, Narducci, Filomena, Mastromauro, Cataldo, Scognamiglio, Rodolfo, Degiovanni, Daniela, Negri, Federica, Caraceni, Augusto, Montanari, Luigi, Maltoni, Marco, Scarpi, Emanuela, Dall'Agata, Monia, Zagonel, Vittorina, Bertè, Raffaella, Ferrari, Daris, Broglia, Chiara Maria, Bortolussi, Roberto, Trentin, Leonardo, Valgiusti, Martina, Pini, Sara, Farolfi, Alberto, Casadei Gardini, Andrea, Nanni, Oriana, and Amadori, Dino

Published
2016
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4. Role of plasma EBV DNA levels in predicting recurrence of nasopharyngeal carcinoma in a western population

Author

Ferrari Daris, Codecà Carla, Bertuzzi Cecilia, Broggio Francesca, Crepaldi Francesca, Luciani Andrea, Floriani Irene, Ansarin Mohssen, Chiesa Fausto, Alterio Daniela, and Foa Paolo

Subjects
Nasopharyngeal carcinoma, Epstein-Barr virus, Chemoradiotherapy, Induction chemotherapy, Plasma EBV DNA copy numbers, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Loco-regionally advanced nasopharyngeal carcinomas can be cured by the combination of chemotherapy and radiotherapy. In Eastern countries, plasma levels of viral Epstein-Barr deoxyribonucleic acid (DNA) are accurate in predicting recurrence, but few data are available in Western populations. The aim of this prospective study was to evaluate the relationship between viral Epstein-Barr DNA copy numbers in plasma and the response rate, progression-free survival and overall survival in a cohort of Western patients with stage IIb-IVb nasopharyngeal cancer. Methods We evaluated plasma samples from 36 consecutive patients treated with induction chemotherapy followed by chemoradiation. EBV copy numbers were determined after DNA extraction using real-time quantitative polymerase chain reaction. Survival curves were estimated using the Kaplan–Meier method. Results Circulating Epstein-Barr virus DNA levels were measured before treatment, at the end of concomitant chemo- and radiotherapy, and during the follow-up period. Pre-treatment levels significantly correlated with the initial stage and probability of relapse. Their increase was 100% specific and 71.3% sensitive in detecting loco-regional or metastatic recurrence (an overall accuracy of 94.4%). Three-year progression-free and overall survival were respectively 78.2% and 97.1%. Conclusions The results of this study confirm that patients from a Western country affected by loco-regionally advanced nasopharyngeal carcinoma have high plasma Epstein-Barr virus DNA levels at diagnosis. The monitoring of plasma levels is sensitive and highly specific in detecting disease recurrence and metastases.

Published
2012
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5. Angiogenesis in Head and Neck Cancer: A Review of the Literature

Author

Ferrari Daris, Codecà Carla, Foa Paolo, Crepaldi Francesca, Broggio Francesca, and Bertuzzi Cecilia

Subjects
Oncology, medicine.medical_specialty, Poor prognosis, Pathology, business.industry, Angiogenesis, medicine.medical_treatment, Head and neck cancer, Advanced stage, Cancer, Review Article, Disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, lcsh:RC254-282, Clinical trial, Radiation therapy, Internal medicine, medicine, business
Abstract

Angiogenesis is a necessary process for tumor growth, progression and diffusion. In the last years many efforts have been made to understand the mechanisms necessary to the formation of new vessels in tumor tissue and how to integrate these findings in the treatment of different type of cancer. Thanks to these studies there are today many anti-angiogenic drugs with established activity in cancer and approved in clinical practice. Head and neck cancer is a common tumor worldwide that often has advanced stage at diagnosis and poor prognosis. Angiogenesis has a well recognized role in head and neck cancer progression and resistance to drugs and radiotherapy and many clinical trials has been conducted with antiangiogenic agents in this disease, even if they often showed limited efficacy. In this review we summarize the main trials published about angiogenesis in head and neck cancer with particular attention to factors involved in this process and the available data on the efficacy of treatment with anti-angiogenic agents in this disease.

Published
2012

6. An unusual case of tracheo-pleural fistula and cardiac metastases in oropharyngeal carcinoma: a case report and review of the literature

Author

Ferrari, Daris, primary, Codecà, Carla, additional, Viale, Giulia, additional, Bocci, Barbara, additional, Broggio, Francesca, additional, Crepaldi, Francesca, additional, Violati, Martina, additional, Luciani, Andrea, additional, Bauer, Dario, additional, Moneghini, Laura, additional, Bulfamante, Gaetano, additional, and Foa, Paolo, additional

Published
2016
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7. Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial

Author

Maltoni, Marco, primary, Scarpi, Emanuela, additional, Dall'Agata, Monia, additional, Zagonel, Vittorina, additional, Bertè, Raffaella, additional, Ferrari, Daris, additional, Broglia, Chiara Maria, additional, Bortolussi, Roberto, additional, Trentin, Leonardo, additional, Valgiusti, Martina, additional, Pini, Sara, additional, Farolfi, Alberto, additional, Casadei Gardini, Andrea, additional, Nanni, Oriana, additional, Amadori, Dino, additional, Frassineti, Giovanni Luca, additional, Sansoni, Elisabetta, additional, Ragazzini, Angela, additional, Ruscelli, Silvia, additional, Crivellari, Gino, additional, Galiano, Antonella, additional, Rodriquenz, Maria Grazia, additional, Biasini, Claudia, additional, Porzio, Rosa, additional, Pittureri, Cristina, additional, Amaducci, Elena, additional, Faedi, Marina, additional, Codecà, Carla, additional, Crepaldi, Francesca, additional, Pedrazzoli, Paolo, additional, Bramanti, Alfina, additional, Buonadonna, Angela, additional, Garetto, Ferdinando, additional, Comandone, Alessandro, additional, Giordano, Monica, additional, Luchena, Giovanna, additional, Luzzani, Massimo, additional, Cifatte, Chiara, additional, Pino, Maria Simona, additional, Zoccali, Sonia, additional, Cattaneo, Maria Teresa, additional, Dalu, Davide, additional, Sozzi, Pietro, additional, Gauna, Roberta, additional, Alquati, Sara, additional, Costantini, Massimo, additional, Quadrini, Silvia, additional, Narducci, Filomena, additional, Mastromauro, Cataldo, additional, Scognamiglio, Rodolfo, additional, Degiovanni, Daniela, additional, Negri, Federica, additional, Caraceni, Augusto, additional, and Montanari, Luigi, additional

Published
2016
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8. Anti-epidermal growth factor receptor skin toxicity

Author

Ferrari, Daris, primary, Codecà, Carla, additional, Bocci, Barbara, additional, Crepaldi, Francesca, additional, Violati, Martina, additional, Viale, Giulia, additional, Careri, Carmela, additional, Caldiera, Sarah, additional, Bordin, Veronica, additional, Luciani, Andrea, additional, Zonato, Sabrina, additional, Cassinelli, Gabriela, additional, and Foa, Paolo, additional

Published
2016
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9. PROBIOTIC-THERAPY IN ONCOLOGY.

Author

Ferrari, Daris, Broggio, Francesca, Crepaldi, Francesca, Violati, Martina, Dottorini, Lorenzo, Codecà, Carla, Battisti, Nicolò, Bordin, Veronica, Luciani, Andrea, and Foa, Paolo

Subjects
*PROBIOTICS, *PREBIOTICS, *COLON cancer treatment, *CANCER chemotherapy, *ONCOLOGY
Abstract

probiotics and prebiotics can exert several beneficial effects in the gastrointestinal tract, such as anti-tumor activity; many studies have been conducted to analyze this activity and its mechanisms. However, their mode of action is not yet well understood. Recent data show the relationship between colon cancer and intestinal bacterial flora. We reviewed the evidence from, different studies in order to prove these beneficial effects on the host. [ABSTRACT FROM AUTHOR]

Published
2013

10. Systematic versus on-demand early palliative care: results from a multicentre, randomised clinical trial

Author

F. Negri, Emanuela Scarpi, Giovanna Luchena, Sara Alquati, Alessandro Comandone, Silvia Quadrini, Maria Simona Pino, Angela Buonadonna, Maria Grazia Rodriquenz, Ferdinando Garetto, Monica Giordano, Rodolfo Scognamiglio, Giovanni Luca Frassineti, Marina Faedi, Paolo Pedrazzoli, Roberta Gauna, Silvia Ruscelli, Massimo Costantini, Chiara Broglia, Filomena Narducci, Antonella Galiano, Sonia Zoccali, Chiara Cifatte, Daniela Degiovanni, Massimo Luzzani, Monia Dall'Agata, Alberto Farolfi, Raffaella Bertè, Vittorina Zagonel, Dino Amadori, Elena Amaducci, Elisabetta Sansoni, Pietro Sozzi, Maria Teresa Cattaneo, Daris Ferrari, Andrea Casadei Gardini, Francesca Crepaldi, Martina Valgiusti, Roberto Bortolussi, Cristina Pittureri, Rosa Porzio, Cataldo Mastromauro, Alfina Bramanti, Angela Ragazzini, Marco Maltoni, Luigi Montanari, Leonardo Trentin, Carla Codecà, Augusto Caraceni, Gino Crivellari, Oriana Nanni, Davide Dalu, Sara Pini, Claudia Biasini, Maltoni, Marco, Scarpi, Emanuela, Dall'Agata, Monia, Zagonel, Vittorina, Bertè, Raffaella, Ferrari, Dari, Broglia, Chiara Maria, Bortolussi, Roberto, Trentin, Leonardo, Valgiusti, Martina, Pini, Sara, Farolfi, Alberto, Casadei Gardini, Andrea, Nanni, Oriana, Amadori, Dino, Frassineti, Giovanni Luca, Sansoni, Elisabetta, Ragazzini, Angela, Ruscelli, Silvia, Crivellari, Gino, Galiano, Antonella, Rodriquenz, Maria Grazia, Biasini, Claudia, Porzio, Rosa, Pittureri, Cristina, Amaducci, Elena, Faedi, Marina, Codecà, Carla, Crepaldi, Francesca, Pedrazzoli, Paolo, Bramanti, Alfina, Buonadonna, Angela, Garetto, Ferdinando, Comandone, Alessandro, Giordano, Monica, Luchena, Giovanna, Luzzani, Massimo, Cifatte, Chiara, Pino, Maria Simona, Zoccali, Sonia, Cattaneo, Maria Teresa, Dalu, Davide, Sozzi, Pietro, Gauna, Roberta, Alquati, Sara, Costantini, Massimo, Quadrini, Silvia, Narducci, Filomena, Mastromauro, Cataldo, Scognamiglio, Rodolfo, Degiovanni, Daniela, Negri, Federica, Caraceni, Augusto, Montanari, Luigi, Maltoni M., Scarpi E., Dall'Agata M., Zagonel V., Berte R., Ferrari D., Broglia C.M., Bortolussi R., Trentin L., Valgiusti M., Pini S., Farolfi A., Casadei Gardini A., Nanni O., Amadori D., Frassineti G.L., Sansoni E., Ragazzini A., Ruscelli S., Crivellari G., Galiano A., Rodriquenz M.G., Biasini C., Porzio R., Pittureri C., Amaducci E., Faedi M., Codeca C., Crepaldi F., Pedrazzoli P., Bramanti A., Buonadonna A., Garetto F., Comandone A., Giordano M., Luchena G., Luzzani M., Cifatte C., Pino M.S., Zoccali S., Cattaneo M.T., Dalu D., Sozzi P., Gauna R., Alquati S., Costantini M., Quadrini S., Narducci F., Mastromauro C., Scognamiglio R., Degiovanni D., Negri F., Caraceni A., and Montanari L.

Subjects
Adult, Male, Quality of life, medicine.medical_specialty, Cancer Research, Palliative care, Anxiety, 03 medical and health sciences, 0302 clinical medicine, Early palliative care, On demand, Internal medicine, Pancreatic cancer, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Patient Comfort, Aged, Quality of Health Care, Aged, 80 and over, Depression, business.industry, Palliative Care, Quality of care, Cancer, Oncology, Middle Aged, medicine.disease, Confidence interval, Pancreatic Neoplasms, Clinical trial, 030220 oncology & carcinogenesis, Physical therapy, Female, business, Cancer pain
Abstract

Background Early palliative care (EPC) in oncology has been shown to have a positive impact on clinical outcome, quality-of-care outcomes, and costs. However, the optimal way for activating EPC has yet to be defined. Methods This prospective, multicentre, randomised study was conducted on 207 outpatients with metastatic or locally advanced inoperable pancreatic cancer. Patients were randomised to receive ‘standard cancer care plus on-demand EPC’ (n=100) or ‘standard cancer care plus systematic EPC’ (n=107). Primary outcome was change in quality of life (QoL) evaluated through the Functional Assessment of Cancer Therapy – Hepatobiliary questionnaire between baseline (T0) and after 12 weeks (T1), in particular the integration of physical, functional, and Hepatic Cancer Subscale (HCS) combined in the Trial Outcome Index (TOI). Patient mood, survival, relatives' satisfaction with care, and indicators of aggressiveness of care were also evaluated. Findings The mean changes in TOI score and HCS score between T0 and T1 were −4.47 and −0.63, with a difference between groups of 3.83 (95% confidence interval [CI] 0.10–7.57) (p=0.041), and −2.23 and 0.28 (difference between groups of 2.51, 95% CI 0.40–4.61, p=0.013), in favour of interventional group. QoL scores at T1 of TOI scale and HCS were 84.4 versus 78.1 (p=0.022) and 52.0 versus 48.2 (p=0.008), respectively, for interventional and standard arm. Until February 2016, 143 (76.9%) of the 186 evaluable patients had died. There was no difference in overall survival between treatment arms. Interpretations Systematic EPC in advanced pancreatic cancer patients significantly improved QoL with respect to on-demand EPC.

Published
2016

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