44 results on '"Delodovici, Maria Luisa"'
Number of results to display per page
Search Results
2. Long-Term Risk of Arterial Thrombosis After Intracerebral Hemorrhage: MUCH-Italy
- Author
-
Pezzini, Alessandro, Iacoviello, Licia, Di Castelnuovo, Augusto, Costanzo, Simona, Tarantino, Barbara, de Gaetano, Giovanni, Zedde, Marialuisa, Marcheselli, Simona, Silvestrelli, Giorgio, Ciccone, Alfonso, DeLodovici, Maria Luisa, Princiotta Cariddi, Lucia, Paciaroni, Maurizio, Azzini, Cristiano, Padroni, Marina, Gamba, Massimo, Magoni, Mauro, Del Sette, Massimo, Tassi, Rossana, De Franco, Ivo Giuseppe, Cavallini, Anna, Calabrò, Rocco Salvatore, Cappellari, Manuel, Giorli, Elisa, Giacalone, Giacomo, Lodigiani, Corrado, Zenorini, Mara, Valletta, Francesco, Pascarella, Rosario, Grisendi, Ilaria, Assenza, Federica, Napoli, Manuela, Moratti, Claudio, Acampa, Maurizio, and Grassi, Mario
- Published
- 2024
- Full Text
- View/download PDF
3. Prevalence of Fabry disease and GLA variants in young patients with acute stroke: The challenge to widen the screening. The Fabry-Stroke Italian Registry
- Author
-
Romani, Ilaria, Sarti, Cristina, Nencini, Patrizia, Pracucci, Giovanni, Zedde, Marialuisa, Cianci, Vittoria, Nucera, Antonia, Moller, Jessica, Orsucci, Daniele, Toni, Danilo, Palumbo, Pasquale, Casella, Carmela, Pinto, Vincenza, Barbarini, Leonardo, Bella, Rita, Scoditti, Umberto, Ragno, Michele, Mezzapesa, Domenico Maria, Tassi, Rossana, Volpi, Gino, Diomedi, Marina, Bigliardi, Guido, Cavallini, Anna Maria, Chiti, Alberto, Ricci, Stefano, Cecconi, Emanuela, Linoli, Giovanni, Sacco, Simona, Rasura, Maurizia, Giordano, Antonello, Bonetti, Bruno, Melis, Marta, Cariddi, Lucia Princiotta, Dossi, Roberto Currò, Grisendi, Ilaria, Aguglia, Umberto, Di Ruzza, Maria Rita, Melis, Maurizio, Sbardella, Emilia, Vista, Marco, Valenti, Raffaella, Musolino, Rosa Fortunata, Passarella, Bruno, Direnzo, Vita, Pennisi, Giovanni, Genovese, Antonio, Di Marzio, Fabio, Sgobio, Rossana, Acampa, Maurizio, Nannucci, Serena, Dagostino, Federica, Dell'Acqua, Maria Luisa, Cuzzoni, Maria Giovanna, Picchioni, Antonella, Calchetti, Benedetta, Notturno, Francesca, Di Lisi, Filomena, Forlivesi, Stefano, Delodovici, Maria Luisa, Buechner, Susanne Christiane, Biagini, Silvia, Accavone, Donatella, Manna, Raffaele, Morrone, Amelia, and Inzitari, Domenico
- Published
- 2024
- Full Text
- View/download PDF
4. COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy)
- Author
-
Martinelli-Boneschi, Filippo, Colombo, Antonio, Bresolin, Nereo, Sessa, Maria, Bassi, Pietro, Grampa, Giampiero, Magni, Eugenio, Versino, Maurizio, Ferrarese, Carlo, Zarcone, Davide, Albanese, Alberto, Micieli, Giuseppe, Zanferrari, Carla, Cagnana, Antonio, Ferrante, Claudio, Zilioli, Angelo, Locatelli, Davide, Calloni, Maria Vittoria, Delodovici, Maria Luisa, Pozzato, Mattia, Patisso, Valerio, Bortolan, Francesco, Foresti, Camillo, Frigeni, Barbara, Canella, Stefania, Xhani, Rubjona, Crabbio, Massimo, Clemenzi, Alessandro, Mauri, Marco, Beretta, Simone, La Spina, Isidoro, Bernasconi, Simona, De Santis, Tiziana, Cavallini, Anna, Ranieri, Michela, D’Adda, Elisabetta, Fruguglietti, Maria Elisa, Peverelli, Lorenzo, Agosti, Edoardo, Leoni, Olivia, Rigamonti, Andrea, and Salmaggi, Andrea
- Published
- 2023
- Full Text
- View/download PDF
5. Correction to: COVID‑19‑associated Guillain‑Barré syndrome in the early pandemic experience in Lombardia (Italy)
- Author
-
Martinelli‑Boneschi, Filippo, Colombo, Antonio, Bresolin, Nereo, Sessa, Maria, Bassi, Pietro, Grampa, Giampiero, Magni, Eugenio, Versino, Maurizio, Ferrarese, Carlo, Zarcone, Davide, Albanese, Alberto, Micieli, Giuseppe, Zanferrari, Carla, Cagnana, Antonio, Ferrante, Claudio, Zilioli, Angelo, Locatelli, Davide, Calloni, Maria Vittoria, Delodovici, Maria Luisa, Pozzato, Mattia, Patisso, Valerio, Bortolan, Francesco, Foresti, Camillo, Frigeni, Barbara, Canella, Stefania, Xhani, Rubjona, Crabbio, Massimo, Clemenzi, Alessandro, Mauri, Marco, Beretta, Simone, La Spina, Isidoro, Bernasconi, Simona, De Santis, Tiziana, Cavallini, Anna, Ranieri, Michela, D’Adda, Elisabetta, Fruguglietti, Maria Elisa, Peverelli, Lorenzo, Agosti, Edoardo, Leoni, Olivia, Rigamonti, Andrea, and Salmaggi, Andrea
- Published
- 2023
- Full Text
- View/download PDF
6. Early seizures and risk of epilepsy and death after intracerebral haemorrhage: The MUCH Italy.
- Author
-
Pezzini, Alessandro, Tarantino, Barbara, Zedde, Marialuisa, Marcheselli, Simona, Silvestrelli, Giorgio, Ciccone, Alfonso, DeLodovici, Maria Luisa, Princiotta Cariddi, Lucia, Vidale, Simone, Paciaroni, Maurizio, Azzini, Cristiano, Padroni, Marina, Gamba, Massimo, Magoni, Mauro, Del Sette, Massimo, Tassi, Rossana, De Franco, Ivo Giuseppe, Cavallini, Anna, Calabrò, Rocco Salvatore, and Cappellari, Manuel
- Published
- 2024
- Full Text
- View/download PDF
7. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy
- Author
-
Halliday, Alison, Bulbulia, Richard, Bonati, Leo H, Peto, Richard, Pan, Hongchao, Potter, John, Henning Eckstein, Hans, Farrell, Barbara, Flather, Marcus, Mansfield, Averil, Mihaylova, Boby, Rahimi, Kazim, Simpson, David, Thomas, Dafydd, Sandercock, Peter, Gray, Richard, Molyneux, Andrew, Shearman, Cliff P, Rothwell, Peter, Belli, Anna, Herrington, Will, Judge, Parminder, Leopold, Peter, Mafham, Marion, Gough, Michael, Cao, Piergiorgio, MacDonald, Sumaira, Bari, Vasha, Berry, Clive, Bradshaw, S, Brudlo, Wojciech, Clarke, Alison, Chester, Johanna, Cox, Robin, Cradduck-Bamford, Andrea, Fathers, Susan, Gaba, Kamran, Gray, Mo, Hayter, Elizabeth, Holliday, Constance, Kurien, Rijo, Lay, Michael, le Conte, Steffi, McManus, Jessica, Madgwick, Zahra, Morris, Dylan, Munday, Andrew, Pickworth, Sandra, Ostasz, Wiktor, Poorthuis, Michiel, Richards, Sue, Teixeira, Louisa, Tochlin, Sergey, Tully, Lynda, Wallis, Carol, Willet, Monique, Young, Alan, Casana, Renato, Malloggi, Chiara, Odero Jr, Andrea, Silani, Vincenzo, Parati, Gianfranco, Malchiodi, Giuseppe, Malferrari, Giovanni, Strozzi, Francesco, Tusini, Nicola, Vecchiati, Enrico, Coppi, Gioacchino, Lauricella, Antonio, Moratto, Roberto, Silingardi, Roberto, Veronesi, Jessica, Zini, Andrea, Ferrero, Emanuele, Ferri, Michelangelo, Gaggiano, Andrea, Labate, Carmelo, Nessi, Franco, Psacharopulo, Daniele, Viazzo, Andrea, Malacrida, Giovanni, Mazzaccaro, Daniela, Meola, Giovanni, Modafferi, Alfredo, Nano, Giovanni, Occhiuto, Maria Teresa, Righini, Paolo, Stegher, Silvia, Chiarandini, Stefano, Griselli, Filippo, Lepidi, Sandro, Pozzi Mucelli, Fabio, Naccarato, Marcello, D'Oria, Mario, Ziani, Barbara, Stella, Andrea, Dieng, Mortalla, Faggioli, Gianluca, Gargiulo, Mauro, Palermo, Sergio, Pini, Rodolfo, Puddu, Giovanni Maria, Vacirca, Andrea, Angiletta, Domenico, Desantis, Claudio, Marinazzo, Davide, Mastrangelo, Giovanni, Regina, Guido, Pulli, Raffaele, Bianchi, Paolo, Cireni, Lea, Coppi, Elisabetta, Pizzirusso, Rocco, Scalise, Filippo, Sorropago, Giovanni, Tolva, Valerio, Caso, Valeria, Cieri, Enrico, DeRango, Paola, Farchioni, Luca, Isernia, Giacomo, Lenti, Massimo, Parlani, Gian Battista, Pupo, Guglielmo, Pula, Grazia, Simonte, Gioele, Verzini, Fabio, Carimati, Federico, Delodovici, Maria Luisa, Fontana, Federico, Piffaretti, Gabriele, Tozzi, Matteo, Civilini, Efrem, Poletto, Giorgio, Reimers, Bernhard, Praquin, Barbara, Ronchey, Sonia, Capoccia, Laura, Mansour, Wassim, Sbarigia, Enrico, Speziale, Francesco, Sirignano, Pasqualino, Toni, Danilo, Galeotti, Roberto, Gasbarro, Vincenzo, Mascoli, Francesco, Rocca, Tiberio, Tsolaki, Elpiniki, Bernardini, Giulia, DeMarco, Ester, Giaquinta, Alessia, Patti, Francesco, Veroux, Massimiliano, Veroux, Pierfrancesco, Virgilio, Carla, Mangialardi, Nicola, Orrico, Matteo, Di Lazzaro, Vincenzo, Montelione, Nunzio, Spinelli, Francesco, Stilo, Francesco, Cernetti, Carlo, Irsara, Sandro, Maccarrone, Giuseppe, Tonello, Diego, Visonà, Adriana, Zalunardo, Beniamino, Chisci, Emiliano, Michelagnoli, Stefano, Troisi, Nicola, Masato, Maela, Dei Negri, Massimo, Pacchioni, Andrea, Saccà, Salvatore, Amatucci, Giovanni, Cannizzaro, Alfredo, Accrocca, Federico, Ambrogi, Cesare, Barbazza, Renzo, Marcucci, Giustino, Siani, Andrea, Bajardi, Guido, Savettieri, Giovanni, Argentieri, Angelo, Corbetta, Riccardo, Odero, Attilio, Quaretti, Pietro, Thyrion, Federico Z, Cappelli, Alessandro, Benevento, Domenico, De Donato, Gianmarco, Mele, Maria Agnese, Palasciano, Giancarlo, Pieragalli, Daniela, Rossi, Alessandro, Setacci, Carlo, Setacci, Francesco, Palombo, Domenico, Perfumo, Maria Cecilia, Martelli, Edoardo, Paolucci, Aldo, Trimarchi, Santi, Grassi, Viviana, Grimaldi, Luigi, La Rosa, Giuliana, Mirabella, Domenico, Scialabba, Matteo, Sichel, Leonildo, D'Angelo, Costantino L, Fadda, Gian Franco, Kasemi, Holta, Marino, Mario, Burzotta, Francesco, Codispoti, Francesco Alberto, Ferrante, Angela, Tinelli, Giovanni, Tshomba, Yamume, Vincenzoni, Claudio, Amis, Deborah, Anderson, Dawn, Catterson, Martin, Clarke, Mike, Davis, Michelle, Dixit, Anand, Dyker, Alexander, Ford, Gary, Jackson, Ralph, Kappadath, Sreevalsan, Lambert, David, Lees, Tim, Louw, Stephen, McCaslin, James, Parr, Noala, Robson, Rebecca, Stansby, Gerard, Wales, Lucy, Wealleans, Vera, Wilson, Lesley, Wyatt, Michael, Baht, Hardeep, Balogun, Ibrahim, Burger, Ilse, Cosier, Tracy, Cowie, Linda, Gunathilagan, Gunaratnam, Hargroves, David, Insall, Robert, Jones, Sally, Rudenko, Hannah, Schumacher, Natasha, Senaratne, Jawaharlal, Thomas, George, Thomson, Audrey, Webb, Tom, Brown, Ellen, Esisi, Bernard, Mehrzad, Ali, MacSweeney, Shane, McConachie, Norman, Southam, Alison, Sunman, Wayne, Abdul-Hamiq, Ahmed, Bryce, Jenny, Chetter, Ian, Ettles, Duncan, Lakshminarayan, Raghuram, Mitchelson, Kim, Rhymes, Christopher, Robinson, Graham, Scott, Paul, Vickers, Alison, Ashleigh, Ray, Butterfield, Stephen, Gamble, Ed, Ghosh, Jonathan, McCollum, Charles N, Welch, Mark, Welsh, Sarah, Wolowczyk, Leszek, Donnelly, Mary, D'Souza, Stephen, Egun, Anselm A, Gregary, Bindu, Joseph, Thomas, Kelly, Christine, Punekar, Shuja, Rahi, M Asad, Raj, Sonia, Seriki, Dare, Thomson, George, Brown, James, Durairajan, Ragunath, Grunwald, Iris, Guyler, Paul, Harman, Paula, Jakeways, Matthew, Khuoge, Christopher, Kundu, Ashish, Loganathan, Thayalini, Menon, Nisha, Prabakaran, Raji O, Sinha, Devesh, Thompson, Vicky, Tysoe, Sharon, Briley, Dennis, Darby, Chris, Hands, Linda, Howard, Dominic, Kuker, Wilhelm, Schulz, Ursula, Teal, Rachel, Barer, David, Brown, Andrew, Crawford, Susan, Dunlop, Paul, Krishnamurthy, Ramesh, Majmudar, Nikhil, Mitchell, Duncan, Myint, Min P, O'Brien, Richard, O'Connell, Janice, Sattar, Naweed, Vetrivel, Shanmugam, Beard, Jonathan, Cleveland, Trevor, Gaines, Peter, Humphreys, John, Jenkins, Alison, King, Craig, Kusuma, Daniel, Lindert, Ralph, Lonsdale, Robbie, Nair, Raj, Nawaz, Shah, Okhuoya, Faith, Turner, Douglas, Venables, Graham, Dorman, Paul, Hughes, Andrea, Jones, Deborah, Mendelow, David, Rodgers, Helen, Raudoniitis, Aidas, Enevoldson, Peter, Nahser, Hans, O'Brien, Imelda, Torella, Francesco, Watling, Dave, White, Richard, Brown, Pauline, Dutta, Dipankar, Emerson, Lorraine, Hilltout, Paula, Kulkarni, Sachin, Morrison, Jackie, Poskitt, Keith, Slim, Fiona, Smith, Sarah, Tyler, Amanda, Waldron, Joanne, Whyman, Mark, Bajoriene, Milda, Baker, Lucy, Colston, Amanda, Eliot-Jones, Bekky, Gramizadeh, Gita, Lewis-Clarke, Catherine, McCafferty, Laura, Oliver, Deborah, Palmer, Debbie, Patil, Abhijeet, Pegler, Suzannah, Ramadurai, Gopi, Roberts, Aisling, Sargent, Tracey, Siddegowda, Shivaprasad, Singh-Ranger, Ravi, Williams, Akintunde, Williams, Lucy, Windebank, Steve, Zuromskis, Tadas, Alwis, Lanka, Angus, Jane, Asokanathan, Asaipillai, Fornolles, Caroline, Hardy, Diana, Hunte, Sophy, Justin, Frances, Phiri, Duke, Mitabouana-Kibou, Marie, Sekaran, Lakshmanan, Sethuraman, Sakthivel, Tate, Margaret L, Akyea-Mensah, Joyce, Ball, Stephen, Chrisopoulou, Angela, Keene, Elizabeth, Phair, Alison, Rogers, Steven, Smyth, John V, Bicknell, Colin, Chataway, Jeremy, Cheshire, Nicholas, Clifton, Andrew, Eley, Caroline, Gibbs, Richard, Hamady, Mohammad, Hazel, Beth, James, Alex, Jenkins, Michael, Khanom, Nyma, Lacey, Austin, Mireskandari, Maz, O'Reilly, Joanna, Pereira, Antony, Sachs, Tina, Wolfe, John, Davey, Philip, Rogers, Gill, Smith, Gemma, Tervit, Gareth, Nichol, Ian, Parry, Andrew, Young, Gavin, Ashley, Simon, Barwell, James, Dix, Francis, Nor, Azlisham M, Parry, Chris, Birt, Angela, Davies, Paul, George, Jim, Graham, Anne, Jonker, Leon, Kelsall, Nicci, Potts, Caroline, Wilson, Toni, Crinnion, Jamie, Cuenoud, Larissa, Aleksic, Nikola, Babic, Srdan, Ilijevski, Nenad, Radak, Đorde, Sagic, Dragan, Tanaskovic, Slobodan, Colic, Momcilo, Cvetic, Vladimir, Davidovic, Lazar, Jovanovic, Dejana R, Koncar, Igor, Mutavdžic, Perica, Sladojevic, Miloš, Tomic, Ivan, Debus, Eike S, Grzyska, Ulrich, Otto, Dagmar, Thomalla, Götz, Barlinn, Jessica, Gerber, Johannes, Haase, Kathrin, Hartmann, Christian, Ludwig, Stefan, Pütz, Volker, Reeps, Christian, Schmidt, Christine, Weiss, Norbert, Werth, Sebastian, Winzer, Simon, Gemper, Janine, Günther, Albrecht, Heiling, Bianka, Jochmann, Elisabeth, Karvouniari, Panagiota, Klingner, Carsten, Mayer, Thomas, Schubert, Julia, Schulze-Hartung, Friederike, Zanow, Jürgen, Bausback, Yvonne, Borger, Franka, Botsios, Spiridon, Branzan, Daniela, Bräunlich, Sven, Hölzer, Henryk, Lenzer, Janin, Piorkowski, Christopher, Richter, Nadine, Schuster, Johannes, Scheinert, Dierk, Schmidt, Andrej, Staab, Holger, Ulrich, Matthias, Werner, Martin, Berger, Hermann, Biró, Gábor, Eckstein, Hans-Henning, Kallmayer, Michael, Kreiser, Kornelia, Zimmermann, Alexander, Berekoven, Bärbel, Frerker, Klaus, Gordon, Vera, Torsello, Giovanni, Arnold, Sebastian, Dienel, Cora, Storck, Martin, Biermaier, Bernhard, Gissler, Hans Martin, Klötzsch, Christof, Pfeiffer, Tomas, Schneider, Ralph, Söhl, Leander, Wennrich, Michael, Alonso, Angelika, Keese, Michael, Groden, Christoph, Cöster, Andreas, Engelhardt, Andreas, Ratusinski, Christoph-Maria, Berg, Bengt, Delle, Martin, Formgren, Johan, Gillgren, Peter, Jarl, Lotta, Kall, Torbjörn B, Konrad, Peter, Nyman, Niklas, Skiöldebrand, Claes, Steuer, Johnny, Takolander, Rabbe, Malmstedt, Jonas, Acosta, Stefan, Björses, Katarina, Brandt, Kerstin, Dias, Nuno, Gottsäter, Anders, Holst, Jan, Kristmundsson, Thorarinn, Kühme, Tobias, Kölbel, Tilo, Lindblad, Bengt, Lindh, Mats, Malina, Martin, Ohrlander, Tomas, Resch, Tim, Rönnle, Viola, Sonesson, Björn, Warvsten, Margareta, Zdanowski, Zbigniew, Campbell, Erik, Kjellin, Per, Lindgren, Hans, Nyberg, Johan, Petersen, Björn, Plate, Gunnar, Pärsson, Håkan, Qvarfordt, Peter, Ignatenko, Pavel, Karpenko, Andrey, Starodubtsev, Vladimir, Chernyavsky, Mikhail A, Golovkova, Maria S, Komakha, Boris B, Zherdev, Nikolay N, Belyasnik, Andrey, Chechulov, Pavel, Kandyba, Dmitry, Stepanishchev, Igor, Csobay-Novák, Csaba, Dósa, Edit, Entz, László, Nemes, Balázs, Szeberin, Zoltán, Barzó, Pál, Bodosi, Mihaly, Fákó, Eniko, Fülöp, Béla, Németh, Tamás, Pazdernyik, Szilárd, Skoba, Krisztina, Vörös, Erika, Chatzinikou, Eleni, Giannoukas, Athanasios, Karathanos, Christos, Koutsias, Stylianos, Kouvelos, Georgios, Matsagkas, Miltiadis, Ralli, Styliani, Rountas, Christos, Rousas, Nikolaos, Spanos, Konstantinos, Brountzos, Elias, Kakisis, John D, Lazaris, Andreas, Moulakakis, Konstantinos G, Stefanis, Leonidas, Tsivgoulis, Georgios, Vasdekis, Spyros, Antonopoulos, Constantine N, Bellenis, Ion, Maras, Dimitrios, Polydorou, Antonios, Polydorou, Victoria, Tavernarakis, Antonios, Ioannou, Nikolaos, Terzoudi, Maria, Lazarides, Miltos, Mantatzis, Michalis, Vadikolias, Kostas, Dzieciuchowicz, Lukasz, Gabriel, Marcin, Krasinski, Zbigniew, Oszkinis, Grzegorz, Pukacki, Fryderyk, Slowinski, Maciej, Stanišic, Michal-Goran, Staniszewski, Ryszard, Tomczak, Jolanta, Zielinski, Maciej, Myrcha, Piotr, Rózanski, Dorota, Drelichowski, Stanislaw, Iwanowski, Wojciech, Koncewicz, Katarzyna, Bialek, Pawel, Biejat, Zbigniew, Czepel, Wojciech, Czlonkowska, Anna, Dowzenko, Anatol, Jedrzejewska, Julia, Kobayashi, Adam, Leszczynski, Jerzy, Malek, Andrzej, Polanski, Jerzy, Proczka, Robert, Skorski, Maciej, Szostek, Mieczyslaw, Andziak, Piotr, Dratwicki, Maciej, Gil, Robert, Nowicki, Miroslaw, Pniewski, Jaroslaw, Rzezak, Jaroslaw, Seweryniak, Piotr, Dabek, Pawel, Juszynski, Michal, Madycki, Grzegorz, Pacewski, Bartosz, Raciborski, Witold, Slowinski, Piotr, Staszkiewicz, Walerian, Bombic, Martin, Chlouba, Vladimír, Fiedler, Jirí, Hes, Karel, Koštál, Petr, Sova, Jindrich, Kríž, Zdenek, Prívara, Mojmír, Reif, Michal, Staffa, Robert, Vlachovský, Robert, Vojtíšek, Bohuslav, Hrbác, Tomáš, Kuliha, Martin, Procházka, Václav, Roubec, Martin, Školoudík, David, Netuka, David, Šteklácová, Anna, Beneš III, Vladimír, Buchvald, Pavel, Endrych, Ladislav, Šercl, Miroslav, Campos Jr, Walter, Casella, Ivan B, de Luccia, Nelson, Estenssoro, André E V, Presti, Calógero, Puech-Leão, Pedro, Neves, Celso R B, da Silva, Erasmo S, Sitrângulo Jr, Cid J, Monteiro, José A T, Tinone, Gisela, Bellini Dalio, Marcelo, Joviliano, Edwaldo E, Pontes Neto, Octávio M, Serra Ribeiro, Mauricio, Cras, Patrick, Hendriks, Jeroen M H, Hoppenbrouwers, Mieke, Lauwers, Patrick, Loos, Caroline, Yperzeele, Laetitia, Geenens, Mia, Hemelsoet, Dimitri, van Herzeele, Isabelle, Vermassen, Frank, Astarci, Parla, Hammer, Frank, Lacroix, Valérie, Peeters, André, Verhelst, Robert, Cirelli, Silvana, Dormal, Pol, Grimonprez, Annelies, Lambrecht, Bart, Lerut, Philipe, Thues, Eddy, De Koster, Guy, Desiron, Quentin, Maertens de Noordhout, Alain, Malmendier, Danielle, Massoz, Mireille, Saad, Georges, Bosiers, Marc, Callaert, Joren, Deloose, Koen, Blanco Cañibano, Estrella, García Fresnillo, Beatriz, Guerra Requena, Mercedes, Morata Barrado, Pilar C, Muela Méndez, Miguel, Yusta Izquierdo, Antonio, Aparici Robles, Fernando, Blanes Orti, Paula, García Dominguez, Luis, Martínez López, Rafael, Miralles Hernández, Manuel, Tembl Ferrairo, José I, Chamorro, Ángel, Macho, Juan, Obach, Víctor, Riambau, Vincent, San Román, Luis, Ahlhelm, Frank J, Blackham, Kristine, Engelter, Stefan, Eugster, Thomas, Gensicke, Henrik, Gürke, Lorenz, Lyrer, Philippe, Mariani, Luigi, Maurer, Marina, Mujagic, Edin, Müller, Mandy, Psychogios, Marios, Stierli, Peter, Stippich, Christoph, Traenka, Christopher, Wolff, Thomas, Wagner, Benjamin, Wiegert, Martina M, Clarke, Sandra, Diepers, Michael, Gröchenig, Ernst, Gruber, Philipp, Isaak, Andrej, Kahles, Timo, Marti, Regula, Nedeltchev, Krassen, Remonda, Luca, Tissira, Nadir, Valença Falcão, Martina, de Borst, Gert J, Lo, Rob H, Moll, Frans L, Toorop, Raechel, van der Worp, Bart H, Vonken, Evert J, Kappelle, Jaap L, Jahrome, Ommid, Vos, Floris, Schuiling, Wouter, van Overhagen, Hendrik, Keunen, Rudolf W M, Knippenberg, Bob, Wever, Jan J, Lardenoije, Jan W, Reijnen, Michel, Smeets, Luuk, van Sterkenburg, Steven, Fraedrich, Gustav, Gizewski, Elke, Gruber, Ingrid, Knoflach, Michael, Kiechl, Stefan, Rantner, Barbara, Abdulamit, Timur, Bergeron, Patrice, Padovani, Raymond, Trastour, Jean-Christophe, Cardon, Jean-Marie, Le Gallou-Wittenberg, Anne, Allaire, Eric, Becquemin, Jean-Pierre, Cochennec-Paliwoda, Frédéric, Desgranges, Pascal, Hosseini, Hassan, Kobeiter, Hicham, Marzelle, Jean, Almekhlafi, Mohammed A, Bal, Simerpreet, Barber, Phillip A, Coutts, Shelagh B, Demchuk, Andrew M, Eesa, Muneer, Gillies, Michelle, Goyal, Mayank, Hill, Michael D, Hudon, Mark E, Jambula, Anitha, Kenney, Carol, Klein, Gary, McClelland, Marie, Mitha, Alim, Menon, Bijoy K, Morrish, William F, Peters, Steven, Ryckborst, Karla J, Samis, Greg, Save, Supriya, Smith, Eric E, Stys, Peter, Subramaniam, Suresh, Sutherland, Garnette R, Watson, Tim, Wong, John H, Zimmel, L, Flis, Vojko, Matela, Jože, Miksic, Kazimir, Milotic, Franko, Mrdja, Božidar, Stirn, Barbara, Tetickovic, Erih, Gasparini, Mladen, Grad, Anton, Kompara, Ingrid, Miloševic, Zoren, Palmiste, Veronika, Toomsoo, Toomas, Aidashova, Balzhan, Kospanov, Nursultan, Lyssenko, Roman, Mussagaliev, Daulet, Beyar, Rafi, Hoffman, Aaron, Karram, Tony, Kerner, Arthur, Nikolsky, Eugenia, Nitecki, Samy, Andonova, Silva, Bachvarov, Chavdar, Petrov, Vesko, Cvjetko, Ivan, Vidjak, Vinko, Halužan, Damir, Petrunic, Mladen, Liu, Bao, Liu, Chang-Wei, Bartko, Daniel, Beno, Peter, Rusnák, František, Zelenák, Kamil, Ezura, Masayuki, Inoue, Takashi, Kimura, Naoto, Kondo, Ryushi, Matsumoto, Yasushi, Shimizu, Hiroaki, Endo, Hidenori, Furui, Eisuke, Bakke, Søren, Krohg-Sørensen, Kristen, Nome, Terje, Skjelland, Mona, Tennøe, Bjørn, Albuquerque e Castro, João, Alves, Gonçalo, Bastos Gonçalves, Frederico, de Aragão Morais, José, Garcia, Ana C, Valentim, Hugo, Vasconcelos, Leonor, Belcastro, Fernando, Cura, Fernando, Zaefferer, Patricio, Abd-Allah, Foad, Eldessoki, Mohamed H, Heshmat Kassem, Hussein, Soliman Gharieb, Haytham, Colgan, Mary P, Haider, Syed N, Harbison, Joe, Madhavan, Prakash, Moore, Dermot, Shanik, Gregor, Kazan, Viviane, Nazzal, Munier, and Ramsey-Williams, Vicki
- Published
- 2021
- Full Text
- View/download PDF
8. Migraine improvement after spontaneous cervical artery dissection the Italian Project on Stroke in Young Adults (IPSYS)
- Author
-
De Giuli, Valeria, Graziano, Francesca, Zini, Andrea, Zedde, Marialuisa, Patella, Rosalba, Lodigiani, Corrado, Marcheselli, Simona, DeLodovici, Maria Luisa, Paciaroni, Maurizio, Casetta, Ilaria, Giorli, Elisa, Adami, Alessandro, Braga, Massimiliano, Casella, Carmela, Giossi, Alessia, Silvestrelli, Giorgio, Tancredi, Lucia, Lotti, Enrico Maria, Poli, Loris, Caria, Filomena, Piras, Valeria, Cucurachi, Laura, Gamba, Massimo, Grassi, Mario, Padovani, Alessandro, Pezzini, Alessandro, and on behalf of the Italian Project on Stroke in Young Adults (IPSYS) Investigators
- Published
- 2019
- Full Text
- View/download PDF
9. Safely Addressing Patients with Atrial Fibrillation to Early Anticoagulation after Acute Stroke
- Author
-
Canavero, Isabella, Cavallini, Anna, Sacchi, Lucia, Quaglini, Silvana, Arnò, Natale, Perrone, Patrizia, DeLodovici, Maria Luisa, Marcheselli, Simona, and Micieli, Giuseppe
- Published
- 2017
- Full Text
- View/download PDF
10. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke
- Author
-
Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, and Toni, Danilo
- Published
- 2019
- Full Text
- View/download PDF
11. Alcohol intake and the risk of intracerebral hemorrhage in the elderly: The MUCH-Italy
- Author
-
Costa, Paolo, Grassi, Mario, Iacoviello, Licia, Zedde, Marialuisa, Marcheselli, Simona, Silvestrelli, Giorgio, DeLodovici, Maria Luisa, Sessa, Maria, Zini, Andrea, Paciaroni, Maurizio, Azzini, Cristiano, Gamba, Massimo, Del Sette, Massimo, Toriello, Antonella, Gandolfo, Carlo, Bonifati, Domenico Marco, Tassi, Rossana, Cavallini, Anna, Chiti, Alberto, Calabrò, Rocco Salvatore, Grillo, Francesco, Bovi, Paolo, Tomelleri, Giampaolo, Di Castelnuovo, Augusto, Ritelli, Marco, Agnelli, Giancarlo, De Vito, Alessandro, Pugliese, Nicola, Martini, Giuseppe, Lodigiani, Corrado, Morotti, Andrea, Poli, Loris, De Giuli, Valeria, Caria, Filomena, Cornali, Claudio, de Gaetano, Giovanni, Colombi, Marina, Padovani, Alessandro, and Pezzini, Alessandro
- Published
- 2018
- Full Text
- View/download PDF
12. Risk Profile of Patients with Spontaneous Cervical Artery Dissection.
- Author
-
Del Zotto, Elisabetta, Grassi, Mario, Zedde, Marialuisa, Zini, Andrea, Bersano, Anna, Gandolfo, Carlo, Silvestrelli, Giorgio, Baracchini, Claudio, Cerrato, Paolo, Lodigiani, Corrado, Marcheselli, Simona, Paciaroni, Maurizio, Spalloni, Alessandra, Cappellari, Manuel, Del Sette, Massimo, Cavallini, Anna, Lotti, Enrico Maria, Delodovici, Maria Luisa, Gentile, Mauro, and Magoni, Mauro
- Subjects
MIGRAINE aura ,YOUNG adults ,FAMILY history (Medicine) ,ISCHEMIC stroke ,STROKE - Abstract
Objective: Epidemiological data to characterize the individual risk profile of patients with spontaneous cervical artery dissection (sCeAD) are rather inconsistent. Methods and Results: In the setting of the Italian Project on Stroke in Young Adults Cervical Artery Dissection (IPSYS CeAD), we compared the characteristics of 1,468 patients with sCeAD (mean age = 47.3 ± 11.3 years, men = 56.7%) prospectively recruited at 39 Italian centers with those of 2 control groups, composed of (1) patients whose ischemic stroke was caused by mechanisms other than dissection (non‐CeAD IS) selected from the prospective IPSYS registry and Brescia Stroke Registry and (2) stroke‐free individuals selected from the staff members of participating hospitals, matched 1:1:1 by sex, age, and race. Compared to stroke‐free subjects, patients with sCeAD were more likely to be hypertensive (odds ratio [OR] = 1.65, 95% confidence interval [CI] = 1.37–1.98), to have personal history of migraine with aura (OR = 2.45, 95% CI = 1.74–3.34), without aura (OR = 2.67, 95% CI = 2.15–3.32), and family history of vascular disease in first‐degree relatives (OR = 1.69, 95% CI = 1.39–2.05), and less likely to be diabetic (OR = 0.65, 95% CI = 0.47–0.91), hypercholesterolemic (OR = 0.75, 95% CI = 0.62–0.91), and obese (OR = 0.41, 95% CI = 0.31–0.54). Migraine without aura was also associated with sCeAD (OR = 1.81, 95% CI = 1.47–2.22) in comparison with patients with non‐CeAD IS. In the subgroup of patients with migraine, patients with sCeAD had higher frequency of migraine attacks and were less likely to take anti‐migraine preventive medications, especially beta‐blockers, compared with the other groups. Interpretation: The risk of sCeAD is influenced by migraine, especially migraine without aura, more than by other factors, increases with increasing frequency of attacks, and seems to be reduced by migraine preventive medications, namely beta‐blockers. ANN NEUROL 2023;94:585–595 [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
13. Correction to: COVID‑19‑associated Guillain‑Barré syndrome in the early pandemic experience in Lombardia (Italy)
- Author
-
Martinelli‑Boneschi, Filippo, primary, Colombo, Antonio, additional, Bresolin, Nereo, additional, Sessa, Maria, additional, Bassi, Pietro, additional, Grampa, Giampiero, additional, Magni, Eugenio, additional, Versino, Maurizio, additional, Ferrarese, Carlo, additional, Zarcone, Davide, additional, Albanese, Alberto, additional, Micieli, Giuseppe, additional, Zanferrari, Carla, additional, Cagnana, Antonio, additional, Ferrante, Claudio, additional, Zilioli, Angelo, additional, Locatelli, Davide, additional, Calloni, Maria Vittoria, additional, Delodovici, Maria Luisa, additional, Pozzato, Mattia, additional, Patisso, Valerio, additional, Bortolan, Francesco, additional, Foresti, Camillo, additional, Frigeni, Barbara, additional, Canella, Stefania, additional, Xhani, Rubjona, additional, Crabbio, Massimo, additional, Clemenzi, Alessandro, additional, Mauri, Marco, additional, Beretta, Simone, additional, La Spina, Isidoro, additional, Bernasconi, Simona, additional, De Santis, Tiziana, additional, Cavallini, Anna, additional, Ranieri, Michela, additional, D’Adda, Elisabetta, additional, Fruguglietti, Maria Elisa, additional, Peverelli, Lorenzo, additional, Agosti, Edoardo, additional, Leoni, Olivia, additional, Rigamonti, Andrea, additional, and Salmaggi, Andrea, additional
- Published
- 2022
- Full Text
- View/download PDF
14. COVID-19-associated Guillain-Barré syndrome in the early pandemic experience in Lombardia (Italy)
- Author
-
Martinelli-Boneschi, Filippo, primary, Colombo, Antonio, additional, Bresolin, Nereo, additional, Sessa, Maria, additional, Bassi, Pietro, additional, Grampa, Giampiero, additional, Magni, Eugenio, additional, Versino, Maurizio, additional, Ferrarese, Carlo, additional, Zarcone, Davide, additional, Albanese, Alberto, additional, Micieli, Giuseppe, additional, Zanferrari, Carla, additional, Cagnana, Antonio, additional, Ferrante, Claudio, additional, Zilioli, Angelo, additional, Locatelli, Davide, additional, Calloni, Maria Vittoria, additional, Delodovici, Maria Luisa, additional, Pozzato, Mattia, additional, Patisso, Valerio, additional, Bortolan, Francesco, additional, Foresti, Camillo, additional, Frigeni, Barbara, additional, Canella, Stefania, additional, Xhani, Rubjona, additional, Crabbio, Massimo, additional, Clemenzi, Alessandro, additional, Mauri, Marco, additional, Beretta, Simone, additional, La Spina, Isidoro, additional, Bernasconi, Simona, additional, De Santis, Tiziana, additional, Cavallini, Anna, additional, Ranieri, Michela, additional, D’Adda, Elisabetta, additional, Fruguglietti, Maria Elisa, additional, Peverelli, Lorenzo, additional, Agosti, Edoardo, additional, Leoni, Olivia, additional, Rigamonti, Andrea, additional, and Salmaggi, Andrea, additional
- Published
- 2022
- Full Text
- View/download PDF
15. Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis
- Author
-
Gori, Anna Maria, Giusti, Betti, Piccardi, Benedetta, Nencini, Patrizia, Palumbo, Vanessa, Nesi, Mascia, Nucera, Antonia, Pracucci, Giovanni, Tonelli, Paolina, Innocenti, Eleonora, Sereni, Alice, Sticchi, Elena, Toni, Danilo, Bovi, Paolo, Guidotti, Mario, Tola, Maria Rosaria, Consoli, Domenico, Micieli, Giuseppe, Tassi, Rossana, Orlandi, Giovanni, Sessa, Maria, Perini, Francesco, Delodovici, Maria Luisa, Zedde, Maria Luisa, Massaro, Francesca, Abbate, Rosanna, and Inzitari, Domenico
- Published
- 2017
- Full Text
- View/download PDF
16. Screening for Fabry disease in patients with ischaemic stroke at young age: the Italian Project on Stroke in Young Adults
- Author
-
Poli, L., Zedde, M., Zini, A., Del Sette, M., Lodigiani, C., Spalloni, A., Di Lisi, F., Toriello, A., Piras, V., Stilo, C., Tomelleri, G., Tancredi, L., Paciaroni, M., Silvestrelli, G., Adami, A., Costa, P., Morotti, A., De Giuli, V., Caria, F., Gamba, M., Malferrari, G., Simone, A. M., Musolino, R., Giorli, E., Banfi, E., Marcheselli, S., Rasura, M., Pugliese, N., Melis, M., Bovi, P., Padovani, A., Burlina, A., Pezzini, A., Del Zotto, Elisabetta, Giossi, Alessia, Sessa, Maria, Gilberti, Nicola, Magoni, Mauro, Ferrazzi, Paola, Librè, Luca, Rota, Lidia Luciana, Patella, Rosalba, Di Liso, Filomena, Calabrò, Rocco Salvatore, Bramanti, Placido, La Spina, Paolo, Finocchi, Cinzia, Balestrino, Maurizio, Bruno, Chiara, Massucco, Davide, Gandolfo, Carlo, Traverso, Elisabetta, DeLodovici, Maria Luisa, Verrengia, Elena Pinuccia, Carimati, Federico, Bono, Giorgio, DellʼAcqua, Maria Luisa, Bigliardi, Guido, Vandelli, Laura, Nichelli, Paolo Frigio, Carletti, Monica, Cerrato, Paolo, Iacoviello, Licia, Di Castelnuovo, Augusto, de Gaetano, Giovanni, Grassi, Mario, Locatelli, Giampiero, Caso, Valeria, DʼAmore, Cataldo, Agnelli, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Arnaboldi, Marco, Giacalone, Giacomo, Zanoli, Elisa, Cavallini, Anna, Persico, Alessandra, Micieli, Giuseppe, Chiti, Alberto, Orlandi, Giovanni, Marchi, Piernicola, Lanari, Alessia, Ciccone, Alfonso, Cucurachi, Laura, Bonifati, Marco Domenico, and Marcello, Norina
- Published
- 2017
- Full Text
- View/download PDF
17. Antithrombotic therapy in the postacute phase of cervical artery dissection: the Italian Project on Stroke in Young Adults Cervical Artery Dissection
- Author
-
Pezzini, Debora, primary, Grassi, Mario, additional, Zedde, Maria Luisa, additional, Zini, Andrea, additional, Bersano, Anna, additional, Gandolfo, Carlo, additional, Silvestrelli, Giorgio, additional, Baracchini, Claudio, additional, Cerrato, Paolo, additional, Lodigiani, Corrado, additional, Marcheselli, Simona, additional, Paciaroni, Maurizio, additional, Rasura, Maurizia, additional, Cappellari, Manuel, additional, Del Sette, Massimo, additional, Cavallini, Anna, additional, Morotti, Andrea, additional, Micieli, Giuseppe, additional, Lotti, Enrico Maria, additional, Delodovici, Maria Luisa, additional, Gentile, Mauro, additional, Magoni, Mauro, additional, Azzini, Cristiano, additional, Calloni, Maria Vittoria, additional, Giorli, Elisa, additional, Braga, Massimiliano, additional, La Spina, Paolo, additional, Melis, Fabio, additional, Tassi, Rossana, additional, Terruso, Valeria, additional, Calabrò, Rocco Salvatore, additional, Piras, Valeria, additional, Giossi, Alessia, additional, Locatelli, Martina, additional, Mazzoleni, Valentina, additional, Sanguigni, Sandro, additional, Zanferrari, Carla, additional, Mannino, Marina, additional, Colombo, Irene, additional, Dallocchio, Carlo, additional, Nencini, Patrizia, additional, Bignamini, Valeria, additional, Adami, Alessandro, additional, Costa, Paolo, additional, Bella, Rita, additional, Pascarella, Rosario, additional, Padovan, Alessandro, additional, and Pezzini, Alessandro, additional
- Published
- 2022
- Full Text
- View/download PDF
18. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
- Author
-
Rheenen, Wouter van, Spek, Rick A. A. van der, Bakker, Mark K., Vugt, Joke J. F. A. van, Hop, Paul J., Zwamborn, Ramona A. J., Klein, Niek de, Westra, Harm Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Needham, Merrilee, Ceroni, Mauro, Simoncini, Costanza, Gagliardi, Stella, Corrado, Lucia, Garton, Fleur C., Mazzini, Letizia, Westeneng, Henk Jan, Ross, Jay P., Valluzzi, Francesco, Aguggia, Marco, Raggi, Flavia, Rini, Augusto, Traynor, Bryan J., Singleton, Andrew B., Ngo, Shyuan T., Corcia, Philippe, Olsen, Catherine M., Hofman, Albert, Van Eijk, Kristel R., Pasterkamp, R. Jeroen, Tittmann, Lukas, Iacoangeli, Alfredo, Mitne Neto, Miguel, Sproviero, Daisy, Cauchi, Ruben J., Ophoff, Roel A., Wiedau Pazos, Martina, Lomen-Hoerth, Catherine, Deerlin, Vivianna M. van, Nicholson, Garth A., Brylev, Lev, Whiteman, David C., Grosskreutz, Julian, Fan, Dongsheng, Couratier, Philippe, Roediger, Annekathrin, Gaur, Nayana, D’alfonso, Sandra, Uitterlinden, André G., Pamphlett, Roger, Fominykh, Vera, Byrne, Ross P., Lieb, Wolfgang, Iazzolino, Barbara, Dekker, Annelot M., Slap Consortium, Demeshonok, Vera, Millecamps, Stéphanie, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaž, Zidar, Janez, Ravnik-Glavač, Metka, Franke, Andre, Mcrae, Allan F., Rowe, Dominic B., Peotta, Laura, Cooper-Knock, Johnathan, Glavač, Damjan, Doherty, Mark, Rietschel, Marcella, Stević, Zorica, Drory, Vivian, Meininger, Vincent, Zarrelli, Michele, Povedano, Monica, Gaunt, Tom R., Steyn, Frederik J., Williams, Kelly L., Smith, Bradley N., Cugnasco, Paolo, Papurello, Diego Maria, Nozzoli, Cecilia, Sorarù, Gianni, Mather, Karen A., Ripke, Stephan, Nöthen, Markus M., Sachdev, Perminder S., Henders, Anjali K., Wallace, Leanne, Carvalho, Mamede de, Gromicho, Marta, Pinto, Susana, Marco, Giovanni de, Al Khleifat, Ahmad, Eberle, Michael A., Braun, Alice, Gusmaroli, Graziano, Siciliano, Gabriele, Petri, Susanne, Breen, Gerome, Weber, Markus, Rouleau, Guy A., Rojas García, Ricardo, Silani, Vincenzo, Amouyel, Philippe, Ghiglione, Paolo, Davey Smith, George, Curtis, Charles J., Shatunov, Aleksey, Mill, Jonathan, Mclaughlin, Russell L., Filosto, Massimiliano, Comi, Cristoforo, Gerfo, Annalisa lo, Ferlini, Alessandra, Riva, Nilo, Mora Pardina, Jesus S., Chiveri, Luca, Hardiman, Orla, Torrieri, Maria Claudia, Kenna, Kevin P., Wray, Naomi R., Tsai, Ellen, Runz, Heiko, Franke, Lude, Padovani, Alessandro, Chandran, Siddharthan, Al Chalabi, Ammar, Assialioui, Abdelilah, Labate, Carmelo, Damme, Philip van, Ticozzi, Nicola, Palumbo, Francesca, Inghilleri, Maurizio, Chiò, Adriano, Pal, Suvankar, Lunetta, Christian, Jörk, Alexander, Cichon, Sven, Kraft, Julia, Morrison, Karen E., Ruiz, Luigi, Shaw, Pamela J., Hardy, John, Orrell, Richard W., Sendtner, Michael, Meyer, Thomas, Dion, Patrick A., Calvo, Andrea, Kooyman, Maarten, Başak, Nazli, Gerardi, Francesca, Simone, Isabella L., Kooi, Anneke J. van der, Ratti, Antonia, Ferrandi, Delfina, Fogh, Isabella, Ludolph, Albert C., Moglia, Cristina, Brunetti, Maura, Diamanti, Luca, Barthel, Tabea, Blair, Ian P., Es, Michael A. van, Gallone, Salvatore, Canosa, Antonio, Guerra, Vito, Grassano, Maurizio, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Ferrarese, Carlo, Nefussy, Beatrice, Theele, Erik, Rinaldi, Fabrizio, Weishaupt, Jochen H., Kiernan, Matthew C., Barberis, Marco, Osmanovic, Alma, Baloh, Robert H., Nordin, Angelica, Lerner, Yossef, Vito, Nicoletta di, Zabari, Michal, Zoccolella, Stefano, Heverin, Mark, Gotkine, Marc, Guaita, Maria Cristina, Brenner, David, Freischmidt, Axel, Sbaiz, Luca, Benyamin, Beben, Glass, Jonathan D., Landers, John E., Tazelaar, Gijs H. P., Rota, Eugenia, Bensimon, Gilbert, Ilse, Benjamin, Brice, Alexis, Durr, Alexandra, Payan, Christine A. M., Saker-Delye, Safa, Wood, Nicholas W., Gentile, Salvatore, Moisse, Matthieu, Topp, Simon, Henderson, Robert D., Rademakers, Rosa, Perrone, Patrizia, Stubendorff, Beatrice, Brown, Robert H., Restuadi, Restuadi, Tremolizzo, Lucio, Mundi, Ciro, Berg, Leonard H. van den, Passarella, Bruno, Delodovici, Maria Luisa, Furlong, Sarah, Bono, Giorgio, Manera, Umberto, Vasta, Rosario, Bombaci, Alessandro, Meineri, Piero, Mauro, Alessandro, Hannon, Eilis, Casale, Federico, Leone, Maurizio, Shaw, Christopher E., Fuda, Giuseppe, Salamone, Paolina, Mathers, Susan, Baird, Denis, Launaro, Nicola, Marchi, Fabiola de, Veldink, Jan H., Gellera, Cinzia, Salachas, François, Witte, Otto W., Andersen, Peter M., Bertolotto, Antonio, Gionco, Maurizio, Leotta, Daniela, Odddenino, Enrico, Slalom Consortium, Tamma, Filippo, Dotta, Michele, Lauria, Giuseppe, Steinbach, Robert, Imperiale, Daniele, Geda, Claudio, Dolzhenko, Egor, Cavallo, Roberto, Pignatta, Pietro, Groen, Ewout J. N., Cotelli, Maria Sofia, Mattei, Marco de, Calabrese, Gianluigi, Sapio, Alessia di, Giardini, Guido, Hübner, Christian A., Corti, Stefania, Bell, Shaughn, Comi, Giancarlo, Mccombe, Pamela A., Tiloca, Cinzia, Parals Consortium, Gawor, Klara, Peverelli, Silvia, Taroni, Franco, Pensato, Viviana, Castellotti, Barbara, Graff, Caroline, Comi, Giacomo P., Cereda, Cristina, Bo, Roberto del, Boero, Giovanni, Slagen Consortium, Vourc’h, Patrick, Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), van Rheenen, Wouter, van der Spek, Rick AA, Bakker, Mark K, van Vugt, Joke JFA, Benyamin, Beben, Veldink, Jan H, SLALOM Consortium, PARALS Consortium, SLAGEN Consortium, SLAP Consortium, van Rheenen, W, van der Spek, R, Bakker, M, van Vugt, J, Hop, P, Zwamborn, R, de Klein, N, Westra, H, Bakker, O, Deelen, P, Shireby, G, Hannon, E, Moisse, M, Baird, D, Restuadi, R, Dolzhenko, E, Dekker, A, Gawor, K, Westeneng, H, Tazelaar, G, van Eijk, K, Kooyman, M, Byrne, R, Doherty, M, Heverin, M, Al Khleifat, A, Iacoangeli, A, Shatunov, A, Ticozzi, N, Cooper-Knock, J, Smith, B, Gromicho, M, Chandran, S, Pal, S, Morrison, K, Shaw, P, Hardy, J, Orrell, R, Sendtner, M, Meyer, T, Basak, N, van der Kooi, A, Ratti, A, Fogh, I, Gellera, C, Lauria, G, Corti, S, Cereda, C, Sproviero, D, D'Alfonso, S, Soraru, G, Siciliano, G, Filosto, M, Padovani, A, Chio, A, Calvo, A, Moglia, C, Brunetti, M, Canosa, A, Grassano, M, Beghi, E, Pupillo, E, Logroscino, G, Nefussy, B, Osmanovic, A, Nordin, A, Lerner, Y, Zabari, M, Gotkine, M, Baloh, R, Bell, S, Vourc'H, P, Corcia, P, Couratier, P, Millecamps, S, Meininger, V, Salachas, F, Mora Pardina, J, Assialioui, A, Rojas-Garcia, R, Dion, P, Ross, J, Ludolph, A, Weishaupt, J, Brenner, D, Freischmidt, A, Bensimon, G, Brice, A, Durr, A, Payan, C, Saker-Delye, S, Wood, N, Topp, S, Rademakers, R, Tittmann, L, Lieb, W, Franke, A, Ripke, S, Braun, A, Kraft, J, Whiteman, D, Olsen, C, Uitterlinden, A, Hofman, A, Rietschel, M, Cichon, S, Nothen, M, Amouyel, P, Traynor, B, Singleton, A, Mitne Neto, M, Cauchi, R, Ophoff, R, Wiedau-Pazos, M, Lomen-Hoerth, C, van Deerlin, V, Grosskreutz, J, Roediger, A, Gaur, N, Jork, A, Barthel, T, Theele, E, Ilse, B, Stubendorff, B, Witte, O, Steinbach, R, Hubner, C, Graff, C, Brylev, L, Fominykh, V, Demeshonok, V, Ataulina, A, Rogelj, B, Koritnik, B, Zidar, J, Ravnik-Glavac, M, Glavac, D, Stevic, Z, Drory, V, Povedano, M, Blair, I, Kiernan, M, Benyamin, B, Henderson, R, Furlong, S, Mathers, S, Mccombe, P, Needham, M, Ngo, S, Nicholson, G, Pamphlett, R, Rowe, D, Steyn, F, Williams, K, Mather, K, Sachdev, P, Henders, A, Wallace, L, de Carvalho, M, Pinto, S, Petri, S, Weber, M, Rouleau, G, Silani, V, Curtis, C, Breen, G, Glass, J, Brown, R, Landers, J, Shaw, C, Andersen, P, Groen, E, van Es, M, Pasterkamp, R, Fan, D, Garton, F, Mcrae, A, Davey Smith, G, Gaunt, T, Eberle, M, Mill, J, Mclaughlin, R, Hardiman, O, Kenna, K, Wray, N, Tsai, E, Runz, H, Franke, L, Al-Chalabi, A, Van Damme, P, van den Berg, L, Veldink, J, Ferrarese, C, Neurology, ANS - Neuroinfection & -inflammation, APH - Methodology, APH - Quality of Care, EURO-NMD, Internal Medicine, Epidemiology, Başak, Ayşe Nazlı (ORCID 0000-0001-9257-3540 & YÖK ID 1512), van Rheenen, W., Van der Spek, R.A.A., Bakker, M.K., van Vugt, J.J.F.A., Hop, P.J., Zwamborn, R.A.J., de Klein, N., Westra, H.J., Bakker, O.B., Deelen, P., Shireby, G., Hannon, E., Moisse, M., Baird, D., Restuadi, R., Dolzhenko, E., Dekker, A.M., Gawor, K., Westeneng, H.J., Tazelaar, G.H.P., van Eijk, K.R., Kooyman, M., Byrne, R.P., Doherty, M., Heverin, M., Al Khleifat, A., Iacoangeli, A., Shatunov, A., Ticozzi, N., Cooper-Knock, J., Smith, B.N., Gromicho, M., Chandran, S., Pal, S., Morrison, K.E., Shaw, P.J., Hardy, J., Orrell, R.W., Sendtner, M., Meyer, T., van der Kooi, A.J., Ratti, A., Fogh, I., Gellera, C., Lauria, G., Corti, S., Cereda, C., Sproviero, D., D'Alfonso, S., Sorarù, G., Siciliano, G., Filosto, M., Padovani, A., Chiò, A., Calvo, A., Moglia, C., Brunetti, M., Canosa, A., Grassano, M., Beghi, E., Pupillo, E., Logroscino, G., Nefussy, B., Osmanovic, A., Nordin, A., Lerner, Y., Zabari, M., Gotkine, M., Baloh, R.H., Bell, S., Vourc'h, P., Corcia, P., Couratier, P., Millecamps, S., Meininger, V., Salachas, F., Mora Pardina, J.S., Assialioui, A., Rojas-García, R., Dion, P.A., Ross, J.P., Ludolph, A.C., Weishaupt, J.H., Brenner, D., Freischmidt, A., Bensimon, G., Brice, A., Durr, A., Payan, C.A.M., Saker-Delye, S., Wood, N.W., Topp, S., Rademakers, R., Tittmann, L., Lieb, W., Franke, A., Ripke, S., Kraft, J.,Whiteman, David C., Olsen, Catherine M., Uitterlinden, A.G., Hofman, A., Rietschel, M., Cichon, S., Nothen, M.M., Amouyel, P., Comi, G., Riva, N., Lunetta, C., Gerardi, F., Cotelli, M.S., Rinaldi, F., Chiveri, L., Guaita, M.C., Perrone, P., Ceroni, M., Diamanti, L., Ferrarese, C., Tremolizzo, L., Delodovici, M.L., Bono, G., Manera, U., Vasta, R., Bombaci, A., Casale, F., Fuda, G., Salamone, P., Iazzolino, B., Peotta, L., Cugnasco, P., De Marco, G., Torrieri, M.C., Palumbo, F., Gallone, S., Barberis, M., Sbaiz, L., Gentile, S., Mauro, A., Mazzini, L., De Marchi, F., Corrado, L., Bertolotto, A., Gionco, M., Leotta, D., Odddenino, E., Imperiale, D., Cavallo, R., Pignatta, P., De Mattei, M., Geda, C., Papurello, D.M., Gusmaroli, G., Comi, C., Labate, C., Ruiz, L., Ferrandi, D., Rota, E., Aguggia, M., Di Vito, N., Meineri, P., Ghiglione, P., Launaro, N., Dotta, M., Di Sapio, A., Giardini, G., Tiloca, C., Peverelli, S., Taroni, F., Pensato, V., Castellotti, B., Comi, G.P., Del Bo, R., Gagliardi, S., Raggi, F., Simoncini, C., Lo Gerfo, A., Inghilleri, M., Ferlini, A., Simone, I.L., Passarella, B., Guerra, V., Zoccolella, S., Nozzoli, C., Mundi, C., Leone, M., Zarrelli, M., Tamma, F., Valluzzi, F., Calabrese, G., Boero, G., Rini, A., Traynor, B.J., Singleton, A.B., Neto, M.M., Cauchi, R.J., Ophoff, R.A., Wiedau-Pazos, M., Lomen-Hoerth, C., van Deerlin, V.M., Grosskreutz, J., Roediger, A., Gaur, N., Jork, A., Barthel, T., Theele, E., Ilse, B., Stubendorff, B., Witte, O.W., Steinbach, R., Hubner, C.A., Graff, C., Brylev, L., Fominykh, V., Demeshonok, V., Ataulina, A., Rogelj, B., Koritnik, B., Zidar, J., Ravnik-Glavac, M., Glavac, D., Stevic, Z., Drory, V., Povedano, M., Blair, I.P., Kiernan, M.C., Benyamin, B., Henderson, R.D., Furlong, S., Mathers, S., McCombe, P.A, Needham, M., Ngo, S.T., Nicholson, G.A., Pamphlett, R., Rowe, D.B., Steyn, F.J., Williams, K.L., Mather, K.A., Sachdev, P.S., Henders, A.K., Wallace, L., de Carvalho, M., Pinto, S., Petri, S., Weber, M., Rouleau, G.A., Silani, V., Curtis, C.J., Breen, G., Glass, J.D., Brown, R.H., Landers, J.E., Shaw, C.E., Andersen, P.M., Groen, E.J.N, van Es, M.A., Pasterkamp, R.J., Fan, D.S., Garton, F.C., McRae, A.F., Smith, G.D., Gaunt, T.R., Eberle, M.A., Mill, J., McLaughlin, R.L., Hardiman, O., Kenna, K.P., Wray, N.R., Tsai, E.L., Runz, H., Franke, L., Al-Chalabi, A., Van Damme, P., van den Berg, L.H., Veldink, J.H., Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM), and School of Medicine
- Subjects
Male ,Genetics and heredity ,amyotrophic lateral sclerosis ,Neurologi ,Glutamine ,Medizin ,Genome-wide association study ,Disease ,SUSCEPTIBILITY ,Genome-wide association studies ,DISEASE ,Genètica mèdica ,0302 clinical medicine ,neurodegenerative disease ,genome-wide association study ,ALS, gene ,autophagy ,Risk Factors ,amyotrophic lateral sclerosi ,RNA-Seq ,Amyotrophic lateral sclerosis ,disease-modifying therapies ,blood [Cholesterol] ,Genetics ,Genetics & Heredity ,Neurons ,0303 health sciences ,Medical genetics ,Neurodegenerative diseases ,Genome-wide association ,Mendelian randomization ,Frontotemporal dementia ,Hexanucleotide repeat ,Mutant SOD1 ,Metaanalysis ,ALS ,Susceptibility ,Identification ,Brain ,Amyotrophic Lateral Sclerosis ,Cholesterol ,Disease Progression ,Female ,Humans ,Mendelian Randomization Analysis ,Microsatellite Repeats ,Neurodegenerative Diseases ,Quantitative Trait Loci ,Genome-Wide Association Study ,Mutation ,MUTANT SOD1 ,genetics [Amyotrophic Lateral Sclerosis] ,medicine.anatomical_structure ,Neurology ,risk factor ,metabolism [Neurons] ,MENDELIAN RANDOMIZATION ,nerve cell ,Life Sciences & Biomedicine ,quantitative trait locu ,Biology ,03 medical and health sciences ,Amyotrophic lateral sclerosis -- Diagnosis ,blood ,ddc:570 ,medicine ,degenerative disease ,Motor neuron disease ,human ,Genomes ,GENOME-WIDE ASSOCIATION ,gene ,Gene ,metabolism [Glutamine] ,METAANALYSIS ,030304 developmental biology ,Mendelian randomization analysi ,Science & Technology ,HEXANUCLEOTIDE REPEAT ,meta analysi ,IDENTIFICATION ,metabolism [Amyotrophic Lateral Sclerosis] ,FRONTOTEMPORAL DEMENTIA ,medicine.disease ,metabolism [Brain] ,genetics [Neurodegenerative Diseases] ,Expression quantitative trait loci ,disease exacerbation ,Neuron ,gemone ,genetic ,Vesicle-mediated transport ,metabolism ,Nervous system -- Degeneration ,Esclerosi lateral amiotròfica ,030217 neurology & neurosurgery - Abstract
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons., Dutch Research Council (NWO); VENI Scheme Grant; VIDI Grant; Prinses Beatrix Spierfonds; Neuromuscular Fellowship Grant; Medical Research Council (MRC); Clinical Infrastructure Award; Epidemiology Unit; Integrative Epidemiology Unit; Canadian Institutes of Health Research; IWT; National Institute on Aging; National Health and Medical Research Council (NHMRC); Enabling Grant; NHMRC/Australian Research Council Strategic Award; NHMRC; NHMRC Centre of Research Excellence Grant; National Health and Medical Research Council of Australia (NHMRC) Research Fellowship; United Kingdom, Medical Research Council; Economic and Social Research Council; European Union (EU); Horizon 2020; European Community's Health Seventh Framework Programme; EuroMOTOR; European Research Council (ERC); Research and Innovation Programme; EScORIAL; ALS Foundation Netherlands; Alzheimer’s Society PhD Studentship; ARSla Funding; Biogen; University of Bristol; Motor Neurone Disease Association (MNDA); NIHR Maudsley Biomedical Research Centre; Dutch Ministry of Education, Culture, and Science; Netherlands Organization for Scientific Research (NWO; BRAINSCAPES); Gravitation Program; ALS Liga België; National Lottery of Belgium; KU Leuven Opening the Future Fund; KU Leuven Funds, “Een Hart voor ALS”, “Laeversfonds voor ALS Onderzoek” and the “Valéry Perrier Race against ALS Fund”; E. von Behring Chair for Neuromuscular and Neurodegenerative Disorders; ALS Liga België; “Live now” Charity Foundation; Moscow ALS palliative Care Service; Canadian Institutes of Health; Research Australia; Ice Bucket Challenge Grant; NIH Intramural Research Programs; FightMND Mid-Career Fellowship; NIHR Senior Investigator; Sheffield NIHR Biomedical Research Centre; Motor Neurone Disease Association; National Institute for Health Research (NIHR) Biomedical Research Centre; Maudsley NHS Foundation Trust; King’s College London; NIHR Senior Investigator Award; Netherlands Organization for Health Research and Development; Vici Scheme; Netherlands Organization for Health Research and Development STRENGTH Project; PPP Allowance
- Published
- 2021
19. Covid-19-associated Guillain-Barré syndrome in the first wave of COVID-19 pandemic in Lombardia: Increased incidence or increased seroprevalence?
- Author
-
Boneschi, Filippo Martinelli, Colombo, Antonio, Bresolin, Nereo, Sessa, Maria, Pozzato, Mattia, Grampa, Giampiero, Bassi, Pietro, Magni, Eugenio, Versino, Maurizio, Ferrarese, Carlo, Zarcone, Davide, Albanese, Alberto, Micieli, Giuseppe, Zanferrari, Carla, Cagnana, Antonio, Ferrante, Claudio, Zilioli, Angelo, Locatelli, Davide, Calloni, Maria, Delodovici, Maria Luisa, Foresti, Camillo, Frigeni, Barbara, Canella, Stefania, Xhani, Rubjona, Crabbio, Massimo, Clemenzi, Alessandro, Mauri, Marco, Beretta, Simone, La Spina, Isidoro, Bernasconi, Simona, Cavallini, Anna, Ranieri, Michela, D'Adda, Elisabetta, Fruguglietti, Maria Elisa, Peverelli, Lorenzo, Agosti, Edoardo, Rigamonti, Andrea, and Salmaggi, Andrea
- Published
- 2021
- Full Text
- View/download PDF
20. Subclinical Vascular Brain Lesions in Young Adults With Acute Ischemic Stroke
- Author
-
De Giuli, Valeria, primary, Grassi, Mario, additional, Besana, Michele, additional, Zedde, Marialuisa, additional, Zini, Andrea, additional, Lodigiani, Corrado, additional, Marcheselli, Simona, additional, Cavallini, Anna, additional, Micieli, Giuseppe, additional, Rasura, Maurizia, additional, DeLodovici, Maria Luisa, additional, Tomelleri, Giampaolo, additional, Checcarelli, Nicoletta, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Tancredi, Lucia, additional, Toriello, Antonella, additional, Braga, Massimiliano, additional, Morotti, Andrea, additional, Pezzini, Debora, additional, Locatelli, Martina, additional, Mazzoleni, Valentina, additional, Bonacina, Sonia, additional, Gamba, Massimo, additional, Magoni, Mauro, additional, Patella, Rosalba, additional, Spalloni, Alessandra, additional, Maria Simone, Anna, additional, Pascarella, Rosario, additional, Beretta, Sandro, additional, Padovani, Alessandro, additional, Gasparotti, Roberto, additional, Pezzini, Alessandro, additional, Gilberti, Nicola, additional, Ferrazzi, Paola, additional, Banfi, Elena, additional, Librè, Luca, additional, Traverso, Elisabetta, additional, Schirinzi, Erika, additional, Carimati, Federico, additional, Cappellari, Manuel, additional, Locatelli, Giampiero, additional, Demelas, Laura, additional, Ferrario, Davide, additional, Persico, Alessandra, additional, Orlandi, Giovanni, additional, Napoli, Manuela, additional, Moratti, Claudio, additional, and Guidotti, Mario, additional
- Published
- 2021
- Full Text
- View/download PDF
21. Age-dependent effect of susceptibility factors on the risk of intracerebral haemorrhage: Multicenter Study on Cerebral Hemorrhage in Italy (MUCH-Italy)
- Author
-
Locatelli, Martina, primary, Grassi, Mario, additional, Saba, Valentina, additional, Iacovello, Licia, additional, di Castelnuovo, Augusto, additional, de Gaetano, Giovanni, additional, Zedde, Marialuisa, additional, Marcheselli, Simona, additional, silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Delodovici, Maria Luisa, additional, Princiotta Cariddi, Lucia, additional, giossi, Alessia, additional, Zini, Andrea, additional, Paciaroni, Maurizio, additional, Acciarresi, Monica, additional, Azzini, Cristiano, additional, De Vito, Alessandro, additional, Gamba, Massimo, additional, Magoni, Mauro, additional, del Sette, Massimo, additional, Toriello, Antonella, additional, Gandolfo, Carlo, additional, Finocchi, Cinzia, additional, Bonifati, Domenico Marco, additional, Tassi, Rossana, additional, Martini, Giuseppe, additional, Cavallini, Anna, additional, Morotti, Andrea, additional, bonacina, sonia, additional, Mazzoleni, Valentina, additional, Pezzini, Debora, additional, Chiti, Alberto, additional, Calabrò, Rocco Salvatore, additional, Musolino, Rosa, additional, La Spina, Paolo, additional, Grillo, Francesco, additional, Tomelleri, Giampaolo, additional, Lodigiani, Corrado, additional, Ritelli, Marco, additional, Colombi, Marina, additional, Padovani, Alessandro, additional, and Pezzini, Alessandro, additional
- Published
- 2021
- Full Text
- View/download PDF
22. Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
- Author
-
van Rheenen, Wouter, van der Spek, Rick A A, Shireby, Gemma, Whiteman, David C, Olsen, Catherine M, Uitterlinden, Andre G, Hofman, Albert, Rietschel, Marcella, Cichon, Sven, Nöthen, Markus M., Amouyel, Philippe, Consortium, SLALOM, Consortium, PARALS, Hannon, Eilis, Consortium, SLAGEN, Consortium, SLAP, Traynor, Bryan J, Singleton, Andrew B, Mitne Neto, Miguel, Cauchi, Ruben J, Ophoff, Roel A, Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, van Deerlin, Vivianna M, Moisse, Matthieu, Grosskreutz, Julian, Roediger, Annekathrin, Gaur, Nayana, Jörk, Alexander, Barthel, Tabea, Theele, Erik, Ilse, Benjamin, Stubendorff, Beatrice, Witte, Otto W, Steinbach, Robert, Baird, Denis, Hübner, Christian A, Graff, Caroline, Brylev, Lev, Fominykh, Vera, Demeshonok, Vera, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaž, Zidar, Janez, Ravnik-Glavač, Metka, Restuadi, Restuadi, Glavač, Damjan, Stević, Zorica, Drory, Vivian, Povedano, Monica, Blair, Ian P, Kiernan, Matthew C, Benyamin, Beben, Henderson, Robert D, Furlong, Sarah, Mathers, Susan, Dolzhenko, Egor, McCombe, Pamela A, Needham, Merrilee, Ngo, Shyuan T, Nicholson, Garth A, Pamphlett, Roger, Rowe, Dominic B, Steyn, Frederik J, Williams, Kelly L, Mather, Karen A, Sachdev, Perminder S, Dekker, Annelot M, Henders, Anjali K, Wallace, Leanne, de Carvalho, Mamede, Pinto, Susana, Petri, Susanne, Weber, Markus, Rouleau, Guy A, Silani, Vincenzo, Curtis, Charles J, Breen, Gerome, Gawor, Klara, Glass, Jonathan D, Brown, Robert H, Landers, John E, Shaw, Christopher E, Andersen, Peter M, Groen, Ewout J N, van Es, Michael A, Pasterkamp, R Jeroen, Fan, Dongsheng, Garton, Fleur C, Westeneng, Henk-Jan, McRae, Allan F, Davey Smith, George, Gaunt, Tom R, Eberle, Michael A, Mill, Jonathan, McLaughlin, Russell L, Hardiman, Orla, Kenna, Kevin P, Wray, Naomi R, Tsai, Ellen, Tazelaar, Gijs H P, Runz, Heiko, Franke, Lude, Al-Chalabi, Ammar, Van Damme, Philip, van den Berg, Leonard H, Veldink, Jan H, Comi, Giancarlo, Riva, Nilo, Lunetta, Christian, Gerardi, Francesca, Bakker, Mark K, van Eijk, Kristel R, Cotelli, Maria Sofia, Rinaldi, Fabrizio, Chiveri, Luca, Guaita, Maria Cristina, Perrone, Patrizia, Ceroni, Mauro, Diamanti, Luca, Ferrarese, Carlo, Tremolizzo, Lucio, Delodovici, Maria Luisa, Kooyman, Maarten, Bono, Giorgio, Canosa, Antonio, Manera, Umberto, Vasta, Rosario, Bombaci, Alessandro, Casale, Federico, Fuda, Giuseppe, Salamone, Paolina, Iazzolino, Barbara, Peotta, Laura, Byrne, Ross P, Cugnasco, Paolo, De Marco, Giovanni, Torrieri, Maria Claudia, Palumbo, Francesca, Gallone, Salvatore, Barberis, Marco, Sbaiz, Luca, Gentile, Salvatore, Mauro, Alessandro, Mazzini, Letizia, Doherty, Mark, De Marchi, Fabiola, Corrado, Lucia, D'Alfonso, Sandra, Bertolotto, Antonio, Gionco, Maurizio, Leotta, Daniela, Odddenino, Enrico, Imperiale, Daniele, Cavallo, Roberto, Pignatta, Pietro, Heverin, Mark, De Mattei, Marco, Geda, Claudio, Papurello, Diego Maria, Gusmaroli, Graziano, Comi, Cristoforo, Labate, Carmelo, Ruiz, Luigi, Ferrandi, Delfina, Rota, Eugenia, Aguggia, Marco, Al Khleifat, Ahmad, Di Vito, Nicoletta, Meineri, Piero, Ghiglione, Paolo, Launaro, Nicola, Dotta, Michele, Di Sapio, Alessia, Giardini, Guido, Tiloca, Cinzia, Peverelli, Silvia, Taroni, Franco, Iacoangeli, Alfredo, Pensato, Viviana, Castellotti, Barbara, Comi, Giacomo P, Del Bo, Roberto, Gagliardi, Stella, Raggi, Flavia, Simoncini, Costanza, Shatunov, Aleksey, Lo Gerfo, Annalisa, Inghilleri, Maurizio, Ferlini, Alessandra, Simone, Isabella L, Passarella, Bruno, Guerra, Vito, Zoccolella, Stefano, Nozzoli, Cecilia, Mundi, Ciro, Leone, Maurizio, Ticozzi, Nicola, Zarrelli, Michele, Tamma, Filippo, Valluzzi, Francesco, Calabrese, Gianluigi, Boero, Giovanni, Rini, Augusto, Cooper-Knock, Johnathan, van Vugt, Joke J F A, Smith, Bradley N, Gromicho, Marta, Chandran, Siddharthan, Pal, Suvankar, Morrison, Karen E, Shaw, Pamela J, Hardy, John, Orrell, Richard W, Sendtner, Michael, Meyer, Thomas, Hop, Paul J, Başak, Nazli, van der Kooi, Anneke J, Ratti, Antonia, Fogh, Isabella, Gellera, Cinzia, Lauria, Giuseppe, Corti, Stefania, Cereda, Cristina, Sproviero, Daisy, Zwamborn, Ramona A J, Sorarù, Gianni, Siciliano, Gabriele, Filosto, Massimiliano, Padovani, Alessandro, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Grassano, Maurizio, de Klein, Niek, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Nefussy, Beatrice, Osmanovic, Alma, Nordin, Angelica, Lerner, Yossef, Zabari, Michal, Gotkine, Marc, Baloh, Robert H, Westra, Harm-Jan, Bell, Shaughn, Vourc'h, Patrick, Corcia, Philippe, Couratier, Philippe, Millecamps, Stéphanie, Meininger, Vincent, Salachas, François, Mora Pardina, Jesus S, Assialioui, Abdelilah, Rojas-García, Ricardo, Bakker, Olivier B, Dion, Patrick A, Ross, Jay P, Ludolph, Albert, Weishaupt, Jochen H, Brenner, David, Freischmidt, Axel, Bensimon, Gilbert, Brice, Alexis, Dürr, Alexandra, Payan, Christine A M, Deelen, Patrick, Saker-Delye, Safa, Wood, Nicholas W, Topp, Simon, Rademakers, Rosa, Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Ripke, Stephan, Braun, Alice, and Kraft, Julia
- Subjects
ddc:570 ,Genetics ,Medizin - Abstract
In the version of this article initially published, the affiliation for Nazli Başak appeared incorrectly. Nazli Başak is at Koç University, School of Medicine, KUTTAM-NDAL, Istanbul, Turkey, and not Bogazici University. The error has been corrected in the HTML and PDF versions of the article.
- Published
- 2021
23. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
- Author
-
van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola, Cooper-Knock, Johnathan, Smith, Bradley N., Gromicho, Marta, Chandran, Siddharthan, Pal, Suvankar, Morrison, Karen E., Shaw, Pamela J., Hardy, John, Orrell, Richard W., Sendtner, Michael, Meyer, Thomas, Basak, Nazli, van der Kooi, Anneke J., Ratti, Antonia, Fogh, Isabella, Gellera, Cinzia, Lauria, Giuseppe, Corti, Stefania, Cereda, Cristina, Sproviero, Daisy, D'Alfonso, Sandra, Soraru, Gianni, Siciliano, Gabriele, Filosto, Massimiliano, Padovani, Alessandro, Chio, Adriano, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Canosa, Antonio, Grassano, Maurizio, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Nefussy, Beatrice, Osmanovic, Alma, Nordin, Angelica, Lerner, Yossef, Zabari, Michal, Gotkine, Marc, Baloh, Robert H., Bell, Shaughn, Vourc'h, Patrick, Corcia, Philippe, Couratier, Philippe, Millecamps, Stephanie, Meininger, Vincent, Salachas, Francois, Mora Pardina, Jesus S., Assialioui, Abdelilah, Rojas-Garcia, Ricardo, Dion, Patrick A., Ross, Jay P., Ludolph, Albert C., Weishaupt, Jochen H., Brenner, David, Freischmidt, Axel, Bensimon, Gilbert, Brice, Alexis, Durr, Alexandra, Payan, Christine A. M., Saker-Delye, Safa, Wood, Nicholas W., Topp, Simon, Rademakers, Rosa, Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Ripke, Stephan, Braun, Alice, Kraft, Julia, Whiteman, David C., Olsen, Catherine M., Uitterlinden, Andre G., Hofman, Albert, Rietschel, Marcella, Cichon, Sven, Nothen, Markus M., Amouyel, Philippe, Comi, Giancarlo, Riva, Nilo, Lunetta, Christian, Gerardi, Francesca, Cotelli, Maria Sofia, Rinaldi, Fabrizio, Chiveri, Luca, Guaita, Maria Cristina, Perrone, Patrizia, Ceroni, Mauro, Diamanti, Luca, Ferrarese, Carlo, Tremolizzo, Lucio, Delodovici, Maria Luisa, Bono, Giorgio, Manera, Umberto, Vasta, Rosario, Bombaci, Alessandro, Casale, Federico, Fuda, Giuseppe, Salamone, Paolina, Iazzolino, Barbara, Peotta, Laura, Cugnasco, Paolo, De Marco, Giovanni, Torrieri, Maria Claudia, Palumbo, Francesca, Gallone, Salvatore, Barberis, Marco, Sbaiz, Luca, Gentile, Salvatore, Mauro, Alessandro, Mazzini, Letizia, De Marchi, Fabiola, Corrado, Lucia, Bertolotto, Antonio, Gionco, Maurizio, Leotta, Daniela, Odddenino, Enrico, Imperiale, Daniele, Cavallo, Roberto, Pignatta, Pietro, De Mattei, Marco, Geda, Claudio, Papurello, Diego Maria, Gusmaroli, Graziano, Comi, Cristoforo, Labate, Carmelo, Ruiz, Luigi, Ferrandi, Delfina, Rota, Eugenia, Aguggia, Marco, Di Vito, Nicoletta, Meineri, Piero, Ghiglione, Paolo, Launaro, Nicola, Dotta, Michele, Di Sapio, Alessia, Giardini, Guido, Tiloca, Cinzia, Peverelli, Silvia, Taroni, Franco, Pensato, Viviana, Castellotti, Barbara, Comi, Giacomo P., Del Bo, Roberto, Gagliardi, Stella, Raggi, Flavia, Simoncini, Costanza, Lo Gerfo, Annalisa, Inghilleri, Maurizio, Ferlini, Alessandra, Simone, Isabella L., Passarella, Bruno, Guerra, Vito, Zoccolella, Stefano, Nozzoli, Cecilia, Mundi, Ciro, Leone, Maurizio, Zarrelli, Michele, Tamma, Filippo, Valluzzi, Francesco, Calabrese, Gianluigi, Boero, Giovanni, Rini, Augusto, Traynor, Bryan J., Singleton, Andrew B., Mitne Neto, Miguel, Cauchi, Ruben J., Ophoff, Roel A., Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, van Deerlin, Vivianna M., Grosskreutz, Julian, Roediger, Annekathrin, Gaur, Nayana, Joerk, Alexander, Barthel, Tabea, Theele, Erik, Ilse, Benjamin, Stubendorff, Beatrice, Witte, Otto W., Steinbach, Robert, Huebner, Christian A., Graff, Caroline, Brylev, Lev, Fominykh, Vera, Demeshonok, Vera, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaz, Zidar, Janez, Ravnik-Glavac, Metka, Glavac, Damjan, Stevic, Zorica, Drory, Vivian, Povedano, Monica, Blair, Ian P., Kiernan, Matthew C., Benyamin, Beben, Henderson, Robert D., Furlong, Sarah, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Ngo, Shyuan T., Nicholson, Garth A., Pamphlett, Roger, Rowe, Dominic B., Steyn, Frederik J., Williams, Kelly L., Mather, Karen A., Sachdev, Perminder S., Henders, Anjali K., Wallace, Leanne, de Carvalho, Mamede, Pinto, Susana, Petri, Susanne, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Curtis, Charles J., Breen, Gerome, Glass, Jonathan D., Brown, Robert H., Jr., Landers, John E., Shaw, Christopher E., Andersen, Peter M., Groen, Ewout J. N., van Es, Michael A., Pasterkamp, R. Jeroen, Fan, Dongsheng, Garton, Fleur C., McRae, Allan F., Davey Smith, George, Gaunt, Tom R., Eberle, Michael A., Mill, Jonathan, McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Wray, Naomi R., Tsai, Ellen, Runz, Heiko, Franke, Lude, Al-Chalabi, Ammar, Van Damme, Philip, van den Berg, Leonard H., Veldink, Jan H., van Rheenen, Wouter, van der Spek, Rick A. A., Bakker, Mark K., van Vugt, Joke J. F. A., Hop, Paul J., Zwamborn, Ramona A. J., de Klein, Niek, Westra, Harm-Jan, Bakker, Olivier B., Deelen, Patrick, Shireby, Gemma, Hannon, Eilis, Moisse, Matthieu, Baird, Denis, Restuadi, Restuadi, Dolzhenko, Egor, Dekker, Annelot M., Gawor, Klara, Westeneng, Henk-Jan, Tazelaar, Gijs H. P., van Eijk, Kristel R., Kooyman, Maarten, Byrne, Ross P., Doherty, Mark, Heverin, Mark, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Shatunov, Aleksey, Ticozzi, Nicola, Cooper-Knock, Johnathan, Smith, Bradley N., Gromicho, Marta, Chandran, Siddharthan, Pal, Suvankar, Morrison, Karen E., Shaw, Pamela J., Hardy, John, Orrell, Richard W., Sendtner, Michael, Meyer, Thomas, Basak, Nazli, van der Kooi, Anneke J., Ratti, Antonia, Fogh, Isabella, Gellera, Cinzia, Lauria, Giuseppe, Corti, Stefania, Cereda, Cristina, Sproviero, Daisy, D'Alfonso, Sandra, Soraru, Gianni, Siciliano, Gabriele, Filosto, Massimiliano, Padovani, Alessandro, Chio, Adriano, Calvo, Andrea, Moglia, Cristina, Brunetti, Maura, Canosa, Antonio, Grassano, Maurizio, Beghi, Ettore, Pupillo, Elisabetta, Logroscino, Giancarlo, Nefussy, Beatrice, Osmanovic, Alma, Nordin, Angelica, Lerner, Yossef, Zabari, Michal, Gotkine, Marc, Baloh, Robert H., Bell, Shaughn, Vourc'h, Patrick, Corcia, Philippe, Couratier, Philippe, Millecamps, Stephanie, Meininger, Vincent, Salachas, Francois, Mora Pardina, Jesus S., Assialioui, Abdelilah, Rojas-Garcia, Ricardo, Dion, Patrick A., Ross, Jay P., Ludolph, Albert C., Weishaupt, Jochen H., Brenner, David, Freischmidt, Axel, Bensimon, Gilbert, Brice, Alexis, Durr, Alexandra, Payan, Christine A. M., Saker-Delye, Safa, Wood, Nicholas W., Topp, Simon, Rademakers, Rosa, Tittmann, Lukas, Lieb, Wolfgang, Franke, Andre, Ripke, Stephan, Braun, Alice, Kraft, Julia, Whiteman, David C., Olsen, Catherine M., Uitterlinden, Andre G., Hofman, Albert, Rietschel, Marcella, Cichon, Sven, Nothen, Markus M., Amouyel, Philippe, Comi, Giancarlo, Riva, Nilo, Lunetta, Christian, Gerardi, Francesca, Cotelli, Maria Sofia, Rinaldi, Fabrizio, Chiveri, Luca, Guaita, Maria Cristina, Perrone, Patrizia, Ceroni, Mauro, Diamanti, Luca, Ferrarese, Carlo, Tremolizzo, Lucio, Delodovici, Maria Luisa, Bono, Giorgio, Manera, Umberto, Vasta, Rosario, Bombaci, Alessandro, Casale, Federico, Fuda, Giuseppe, Salamone, Paolina, Iazzolino, Barbara, Peotta, Laura, Cugnasco, Paolo, De Marco, Giovanni, Torrieri, Maria Claudia, Palumbo, Francesca, Gallone, Salvatore, Barberis, Marco, Sbaiz, Luca, Gentile, Salvatore, Mauro, Alessandro, Mazzini, Letizia, De Marchi, Fabiola, Corrado, Lucia, Bertolotto, Antonio, Gionco, Maurizio, Leotta, Daniela, Odddenino, Enrico, Imperiale, Daniele, Cavallo, Roberto, Pignatta, Pietro, De Mattei, Marco, Geda, Claudio, Papurello, Diego Maria, Gusmaroli, Graziano, Comi, Cristoforo, Labate, Carmelo, Ruiz, Luigi, Ferrandi, Delfina, Rota, Eugenia, Aguggia, Marco, Di Vito, Nicoletta, Meineri, Piero, Ghiglione, Paolo, Launaro, Nicola, Dotta, Michele, Di Sapio, Alessia, Giardini, Guido, Tiloca, Cinzia, Peverelli, Silvia, Taroni, Franco, Pensato, Viviana, Castellotti, Barbara, Comi, Giacomo P., Del Bo, Roberto, Gagliardi, Stella, Raggi, Flavia, Simoncini, Costanza, Lo Gerfo, Annalisa, Inghilleri, Maurizio, Ferlini, Alessandra, Simone, Isabella L., Passarella, Bruno, Guerra, Vito, Zoccolella, Stefano, Nozzoli, Cecilia, Mundi, Ciro, Leone, Maurizio, Zarrelli, Michele, Tamma, Filippo, Valluzzi, Francesco, Calabrese, Gianluigi, Boero, Giovanni, Rini, Augusto, Traynor, Bryan J., Singleton, Andrew B., Mitne Neto, Miguel, Cauchi, Ruben J., Ophoff, Roel A., Wiedau-Pazos, Martina, Lomen-Hoerth, Catherine, van Deerlin, Vivianna M., Grosskreutz, Julian, Roediger, Annekathrin, Gaur, Nayana, Joerk, Alexander, Barthel, Tabea, Theele, Erik, Ilse, Benjamin, Stubendorff, Beatrice, Witte, Otto W., Steinbach, Robert, Huebner, Christian A., Graff, Caroline, Brylev, Lev, Fominykh, Vera, Demeshonok, Vera, Ataulina, Anastasia, Rogelj, Boris, Koritnik, Blaz, Zidar, Janez, Ravnik-Glavac, Metka, Glavac, Damjan, Stevic, Zorica, Drory, Vivian, Povedano, Monica, Blair, Ian P., Kiernan, Matthew C., Benyamin, Beben, Henderson, Robert D., Furlong, Sarah, Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Ngo, Shyuan T., Nicholson, Garth A., Pamphlett, Roger, Rowe, Dominic B., Steyn, Frederik J., Williams, Kelly L., Mather, Karen A., Sachdev, Perminder S., Henders, Anjali K., Wallace, Leanne, de Carvalho, Mamede, Pinto, Susana, Petri, Susanne, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Curtis, Charles J., Breen, Gerome, Glass, Jonathan D., Brown, Robert H., Jr., Landers, John E., Shaw, Christopher E., Andersen, Peter M., Groen, Ewout J. N., van Es, Michael A., Pasterkamp, R. Jeroen, Fan, Dongsheng, Garton, Fleur C., McRae, Allan F., Davey Smith, George, Gaunt, Tom R., Eberle, Michael A., Mill, Jonathan, McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Wray, Naomi R., Tsai, Ellen, Runz, Heiko, Franke, Lude, Al-Chalabi, Ammar, Van Damme, Philip, van den Berg, Leonard H., and Veldink, Jan H.
- Abstract
A cross-ancestry genome-wide association meta-analysis of amyotrophic lateral sclerosis (ALS) including 29,612 patients with ALS and 122,656 controls identifies 15 risk loci with distinct genetic architectures and neuron-specific biology. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 individuals with whole-genome sequencing (6,538 patients, 2,415 controls) and a large cortex-derived expression quantitative trait locus (eQTL) dataset (MetaBrain), analyses revealed locus-specific genetic architectures in which we prioritized genes either through rare variants, short tandem repeats or regulatory effects. ALS-associated risk loci were shared with multiple traits within the neurodegenerative spectrum but with distinct enrichment patterns across brain regions and cell types. Of the environmental and lifestyle risk factors obtained from the literature, Mendelian randomization analyses indicated a causal role for high cholesterol levels. The combination of all ALS-associated signals reveals a role for perturbations in vesicle-mediated transport and autophagy and provides evidence for cell-autonomous disease initiation in glutamatergic neurons.
- Published
- 2021
- Full Text
- View/download PDF
24. Clinical Features of Patients With Cervical Artery Dissection and Fibromuscular Dysplasia
- Author
-
Bonacina, Sonia, primary, Grassi, Mario, additional, Zedde, Marialuisa, additional, Zini, Andrea, additional, Bersano, Anna, additional, Gandolfo, Carlo, additional, Silvestrelli, Giorgio, additional, Baracchini, Claudio, additional, Cerrato, Paolo, additional, Lodigiani, Corrado, additional, Marcheselli, Simona, additional, Paciaroni, Maurizio, additional, Rasura, Maurizia, additional, Cappellari, Manuel, additional, Del Sette, Massimo, additional, Cavallini, Anna, additional, Morotti, Andrea, additional, Micieli, Giuseppe, additional, Lotti, Enrico Maria, additional, DeLodovici, Maria Luisa, additional, Gentile, Mauro, additional, Magoni, Mauro, additional, Azzini, Cristiano, additional, Calloni, Maria Vittoria, additional, Giorli, Elisa, additional, Braga, Massimiliano, additional, La Spina, Paolo, additional, Melis, Fabio, additional, Tassi, Rossana, additional, Terruso, Valeria, additional, Calabrò, Rocco Salvatore, additional, Piras, Valeria, additional, Giossi, Alessia, additional, Locatelli, Martina, additional, Mazzoleni, Valentina, additional, Pezzini, Debora, additional, Sanguigni, Sandro, additional, Zanferrari, Carla, additional, Mannino, Marina, additional, Colombo, Irene, additional, Dallocchio, Carlo, additional, Nencini, Patrizia, additional, Bignamini, Valeria, additional, Adami, Alessandro, additional, Magni, Eugenio, additional, Bella, Rita, additional, Padovani, Alessandro, additional, Pezzini, Alessandro, additional, Pascarella, Rosario, additional, Sessa, Maria, additional, Scelzo, Emma, additional, Bandettini di Poggio, Monica Laura, additional, Boscain, Francesca, additional, Naldi, Andrea, additional, Caso, Valeria, additional, Gamba, Massimo, additional, Casetta, Ilaria, additional, Forlivesi, Stefano, additional, Tomelleri, Giampaolo, additional, Schirinzi, Elena, additional, Verrengia, Elena, additional, Nuzzaco, Graziamaria, additional, Beretta, Sandro, additional, Musolino, Rossella, additional, Imperiale, Daniele, additional, Acampa, Maurizio, additional, Gasparro, Antonio, additional, Melis, Maurizio, additional, Fisicaro, Francesco, additional, Santilli, Ignazio, additional, Corato, Manuel, additional, Padroni, Marina, additional, Leuci, Eleonora, additional, Mazzacane, Federico, additional, Gaiani, Alessandra, additional, Assenza, Federica, additional, Cariddi, Lucia Princiotta, additional, Sarti, Cristina, additional, Monaco, Serena, additional, Puca, Emanuele, additional, and Ciolli, Ludovico, additional
- Published
- 2021
- Full Text
- View/download PDF
25. Intravenous Thrombolysis for Acute Ischemic Stroke Associated to Extracranial Internal Carotid Artery Occlusion: The ICARO-2 Study
- Author
-
Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Pieroni, Alessio, Bovi, Paolo, Cappellari, Manuel, Zini, Andrea, Nichelli, Paolo, Inzitari, Domenico, Nesi, Mascia, Nencini, Patrizia, Pezzini, Alessandro, Padovani, Alessandro, Tassinari, Tiziana, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Luda, Emilio, Tassi, Rossana, Martini, Giuseppe, Ferrarese, Carlo, Beretta, Simone, Trentini, Claudia, Silvestrelli, Giorgio, Lanari, Alessia, Previdi, Paolo, Ciccone, Alfonso, DeLodovici, Maria Luisa, Bono, Giorgio, Galletti, Giampiero, Marcheselli, Simona, Del Sette, Massimo, Traverso, Elisabetta, Riva, Maurizio, Silvestrini, Mauro, Cerqua, Raffaella, Consoli, Domenico, Monaco, Serena, and Toni, Danilo
- Published
- 2012
- Full Text
- View/download PDF
26. Subclinical Vascular Brain Lesions in Young Adults With Acute Ischemic Stroke.
- Author
-
De Giuli, Valeria, Grassi, Mario, Besana, Michele, Zedde, Marialuisa, Zini, Andrea, Lodigiani, Corrado, Marcheselli, Simona, Cavallini, Anna, Micieli, Giuseppe, Rasura, Maurizia, DeLodovici, Maria Luisa, Tomelleri, Giampaolo, Checcarelli, Nicoletta, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Tancredi, Lucia, Toriello, Antonella, Braga, Massimiliano, and Morotti, Andrea
- Published
- 2022
- Full Text
- View/download PDF
27. Interaction between proatherosclerotic factors and right-to-left shunt on the risk of cryptogenic stroke: the Italian Project on Stroke in Young Adults
- Author
-
Pezzini, Alessandro, Grassi, Mario, Lodigiani, Corrado, Patella, Rosalba, Gandolfo, Carlo, Zini, Andrea, Musolino, Rossella, Calabrò, Rocco Salvatore, Bovi, Paolo, Adami, Alessandro, DeLodovici, Maria Luisa, Del Zotto, Elisabetta, Rota, Lidia Luciana, Rasura, Maurizia, Del Sette, Massimo, Spalloni, Alessandra, Giossi, Alessia, Volonghi, Irene, Casoni, Federica, Cerrato, Paolo, Costa, Paolo, Magoni, Mauro, Toriello, Antonella, Paciaroni, Maurizio, Volta, Giorgio Dalla, Iacoviello, Licia, and Padovani, Alessandro
- Published
- 2012
- Full Text
- View/download PDF
28. Systemic Thrombolysis in Patients With Acute Ischemic Stroke and Internal Carotid ARtery Occlusion: The ICARO Study
- Author
-
Paciaroni, Maurizio, Balucani, Clotilde, Agnelli, Giancarlo, Caso, Valeria, Silvestrelli, Giorgio, Grotta, James C., Demchuk, Andrew M., Sohn, Sung-Il, Orlandi, Giovanni, Leys, Didier, Pezzini, Alessandro, Alexandrov, Andrei V., Silvestrini, Mauro, Fofi, Luisa, Barlinn, Kristian, Inzitari, Domenico, Ferrarese, Carlo, Tassi, Rossana, Tsivgoulis, Georgios, Consoli, Domenico, Baldi, Antonio, Bovi, Paolo, Luda, Emilio, Galletti, Giampiero, Invernizzi, Paolo, DeLodovici, Maria Luisa, Corea, Francesco, Del Sette, Massimo, Monaco, Serena, Marcheselli, Simona, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, DʼAmore, Cataldo, Macellari, Federica, Lanari, Alessia, Previdi, Paolo, Gonzales, Nicole R., Pandurengan, Renganayaki K., Vahidy, Farhaan S., Sline, Melvin, Bal, Simerpreet S., Chiti, Alberto, Gialdini, Gino, Dumont, Frederic, Cordonnier, Charlotte, Debette, Stéphanie, Padovani, Alessandro, Cerqua, Raffaella, Bodechtel, Ulf, Kepplinger, Jessica, Nesi, Mascia, Nencini, Patrizia, Beretta, Simone, Trentini, Claudia, Martini, Giuseppe, Piperidou, Charitomeni, Heliopoulos, Ioannis, DʼAnna, Sebastiano, Cappellari, Manuel, Donati, Edoardo, Bono, Giorgio, Traverso, Elisabetta, and Toni, Danilo
- Published
- 2012
- Full Text
- View/download PDF
29. Predictors of Migraine Subtypes in Young Adults With Ischemic Stroke: The Italian Project on Stroke in Young Adults
- Author
-
Pezzini, Alessandro, Grassi, Mario, Lodigiani, Corrado, Patella, Rosalba, Gandolfo, Carlo, Casoni, Federica, Musolino, Rossella, Salvatore Calabrò, Rocco, Bovi, Paolo, Adami, Alessandro, DeLodovici, Maria Luisa, Del Zotto, Elisabetta, Rota, Lidia Luciana, Rasura, Maurizia, Del Sette, Massimo, Giossi, Alessia, Volonghi, Irene, Zini, Andrea, Cerrato, Paolo, Costa, Paolo, Magoni, Mauro, Iacoviello, Licia, and Padovani, Alessandro
- Published
- 2011
- Full Text
- View/download PDF
30. Endovascular Treatment of Carotid Stump Syndrome
- Author
-
Carrafiello, Gianpaolo, DeLodovici, Maria Luisa, Piffaretti, Gabriele, and Castelli, Patrizio
- Published
- 2009
31. Supplemental material for IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke
- Author
-
Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, Vito, Alessandro De, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, Michele, Manuela De, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria F, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, and Toni, Danilo
- Subjects
FOS: Clinical medicine ,Cardiology ,Medicine ,110904 Neurology and Neuromuscular Diseases - Abstract
Supplemental Material for IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke by Manuel Cappellari, Salvatore Mangiafico, Valentina Saia, Giovanni Pracucci, Sergio Nappini, Patrizia Nencini, Daniel Konda, Fabrizio Sallustio, Stefano Vallone, Andrea Zini, Sandra Bracco, Rossana Tassi, Mauro Bergui, Paolo Cerrato, Antonio Pitrone, Francesco Grillo, Andrea Saletti, Alessandro De Vito, Roberto Gasparotti, Mauro Magoni, Edoardo Puglielli, Alfonsina Casalena, Francesco Causin, Claudio Baracchini, Lucio Castellan, Laura Malfatto, Roberto Menozzi, Umberto Scoditti, Chiara Comelli, Enrica Duc, Alessio Comai, Enrica Franchini, Mirco Cosottini, Michelangelo Mancuso, Simone Peschillo, Manuela De Michele, Andrea Giorgianni, Maria Luisa Delodovici, Elvis Lafe, Maria F Denaro, Nicola Burdi, Saverio Internò, Nicola Cavasin, Adriana Critelli, Luigi Chiumarulo, Marco Petruzzellis, Marco Doddi, Antonio Carolei, William Auteri, Alfredo Petrone, Riccardo Padolecchia, Tiziana Tassinari, Marco Pavia, Paolo Invernizzi, Gianni Turcato, Stefano Forlivesi, Elisa Francesca Maria Ciceri, Bruno Bonetti, Domenico Inzitari and Danilo Toni in International Journal of Stroke
- Published
- 2019
- Full Text
- View/download PDF
32. Long-term outcome of cervical artery dissection : IPSYS CeAD: study protocol, rationale, and baseline data of an Italian multicenter research collaboration.
- Author
-
Bonacina, Sonia, Grassi, Mario, Zedde, Marialuisa, Zini, Andrea, Bersano, Anna, Gandolfo, Carlo, Silvestrelli, Giorgio, Baracchini, Claudio, Cerrato, Paolo, Lodigiani, Corrado, Marcheselli, Simona, Paciaroni, Maurizio, Rasura, Maurizia, Cappellari, Manuel, Del Sette, Massimo, Cavallini, Anna, Morotti, Andrea, Micieli, Giuseppe, Lotti, Enrico Maria, and DeLodovici, Maria Luisa
- Subjects
TRANSIENT ischemic attack ,CEREBRAL ischemia ,CAROTID artery dissections ,ARTERIES ,STROKE treatment ,RESEARCH ,STROKE ,MEDICAL cooperation ,HUMAN dissection ,RESEARCH funding ,VERTEBRAL artery dissections ,VETERINARY dissection ,LONGITUDINAL method - Abstract
Long-term consequences of cervical artery dissection (CeAD), a major cause of ischemic stroke in young people, have been poorly investigated. The Italian Project on Stroke at Young Age - Cervical Artery Dissection (IPSYS CeAD) project is a multicenter, hospital-based, consecutively recruiting, observational, cohort study aimed to address clinically important questions about long-term outcome of CeAD patients, which are not covered by other large-scale registries. Patients with radiologically diagnosed CeAD were consecutively included in the registry. Baseline demographic and clinical variables, as well as information on risk factors, were systematically collected for each eligible patient. Follow-up evaluations were conducted between 3 and 6 months after the initial event (t1) and then annually (t2 at 1 year, t3 at 2 years , and so on), in order to assess outcome events (long-term recurrent CeAD, any fatal/nonfatal ischemic stroke, transient ischemic attack (TIA), or other arterial thrombotic event, and death from any cause). Between 2000 and 2019, data from 1530 patients (age at diagnosis, 47.2 ± 11.5 years; women, 660 [43.1%]) have been collected at 39 Italian neurological centers. Dissection involved a single vessel in 1308 (85.5%) cases and caused brain ischemia in 1303 (85.1%) (190 TIA/1113 ischemic stroke). Longitudinal data are available for 1414 (92.4%) patients (median follow-up time in patients who did not experience recurrent events, 36.0 months [25th to 75th percentile, 63.0]). The collaborative IPSYS CeAD effort will provide novel information on the long-term outcome of CeAD patients. This could allow for tailored treatment approaches based on patients' individual characteristics. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
33. Migraine and Cryptogenic Ischemic Stroke.
- Author
-
Mazzoleni, Valentina, Grassi, Mario, Lodigiani, Corrado, Rasura, Maurizia, Zedde, Marialuisa, Gandolfo, Carlo, Zini, Andrea, DeLodovici, Maria Luisa, Paciaroni, Maurizio, Del Sette, Massimo, Toriello, Antonella, Musolino, Rossella, Calabrò, Rocco Salvatore, Bovi, Paolo, Giossi, Alessia, Adami, Alessandro, Silvestrelli, Giorgio, Cavallini, Anna, Marcheselli, Simona, and Bonifati, Domenico Marco
- Subjects
MIGRAINE aura ,MIGRAINE ,TRANSCRANIAL Doppler ultrasonography ,ISCHEMIC stroke ,CEREBRAL infarction - Abstract
The available evidence on the relationship between migraine and cryptogenic ischemic stroke (CIS) is scarce. Thirty-six cases had missing data in the variable "any migraine"; 70 participants (58 cases and 12 control subjects) had missing data in the variables "migraine without aura" and "migraine with aura.". [Extracted from the article]
- Published
- 2021
- Full Text
- View/download PDF
34. Propensity Score–Based Analysis of Percutaneous Closure Versus Medical Therapy in Patients With Cryptogenic Stroke and Patent Foramen Ovale
- Author
-
Pezzini, Alessandro, primary, Grassi, Mario, additional, Lodigiani, Corrado, additional, Patella, Rosalba, additional, Gandolfo, Carlo, additional, Zini, Andrea, additional, DeLodovici, Maria Luisa, additional, Paciaroni, Maurizio, additional, Del Sette, Massimo, additional, Toriello, Antonella, additional, Musolino, Rossella, additional, Calabrò, Rocco Salvatore, additional, Bovi, Paolo, additional, Adami, Alessandro, additional, Silvestrelli, Giorgio, additional, Sessa, Maria, additional, Cavallini, Anna, additional, Marcheselli, Simona, additional, Marco Bonifati, Domenico, additional, Checcarelli, Nicoletta, additional, Tancredi, Lucia, additional, Chiti, Alberto, additional, Del Zotto, Elisabetta, additional, Tomelleri, Giampaolo, additional, Spalloni, Alessandra, additional, Giorli, Elisa, additional, Costa, Paolo, additional, Giacalone, Giacomo, additional, Ferrazzi, Paola, additional, Poli, Loris, additional, Morotti, Andrea, additional, Piras, Valeria, additional, Rasura, Maurizia, additional, Simone, Anna Maria, additional, Gamba, Massimo, additional, Cerrato, Paolo, additional, Zedde, Maria Luisa, additional, Micieli, Giuseppe, additional, Melis, Maurizio, additional, Massucco, Davide, additional, Guido, Davide, additional, De Giuli, Valeria, additional, Bonaiti, Silvia, additional, D’Amore, Cataldo, additional, La Starza, Sara, additional, Iacoviello, Licia, additional, and Padovani, Alessandro, additional
- Published
- 2016
- Full Text
- View/download PDF
35. Serum cholesterol levels, HMG-CoA reductase inhibitors and the risk of intracerebral haemorrhage. The Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy)
- Author
-
Pezzini, Alessandro, primary, Grassi, Mario, additional, Iacoviello, Licia, additional, Zedde, Marialuisa, additional, Marcheselli, Simona, additional, Silvestrelli, Giorgio, additional, DeLodovici, Maria Luisa, additional, Sessa, Maria, additional, Zini, Andrea, additional, Paciaroni, Maurizio, additional, Azzini, Cristiano, additional, Gamba, Massimo, additional, Del Sette, Massimo, additional, Toriello, Antonella, additional, Gandolfo, Carlo, additional, Bonifati, Domenico Marco, additional, Tassi, Rossana, additional, Cavallini, Anna, additional, Chiti, Alberto, additional, Calabrò, Rocco Salvatore, additional, Musolino, Rossella, additional, Bovi, Paolo, additional, Tomelleri, Giampaolo, additional, Di Castelnuovo, Augusto, additional, Vandelli, Laura, additional, Ritelli, Marco, additional, Agnelli, Giancarlo, additional, De Vito, Alessandro, additional, Pugliese, Nicola, additional, Martini, Giuseppe, additional, Lanari, Alessia, additional, Ciccone, Alfonso, additional, Lodigiani, Corrado, additional, Malferrari, Giovanni, additional, Del Zotto, Elisabetta, additional, Morotti, Andrea, additional, Costa, Paolo, additional, Poli, Loris, additional, De Giuli, Valeria, additional, Bonaiti, Silvia, additional, La Spina, Paolo, additional, Marcello, Norina, additional, Micieli, Giuseppe, additional, de Gaetano, Giovanni, additional, Colombi, Marina, additional, and Padovani, Alessandro, additional
- Published
- 2016
- Full Text
- View/download PDF
36. Unbalanced Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinases Ratios Predict Hemorrhagic Transformation of Lesion in Ischemic Stroke Patients Treated with Thrombolysis: Results from the MAGIC Study
- Author
-
Piccardi, Benedetta, primary, Palumbo, Vanessa, additional, Nesi, Mascia, additional, Nencini, Patrizia, additional, Gori, Anna Maria, additional, Giusti, Betti, additional, Pracucci, Giovanni, additional, Tonelli, Paolina, additional, Innocenti, Eleonora, additional, Sereni, Alice, additional, Sticchi, Elena, additional, Toni, Danilo, additional, Bovi, Paolo, additional, Guidotti, Mario, additional, Tola, Maria Rosaria, additional, Consoli, Domenico, additional, Micieli, Giuseppe, additional, Tassi, Rossana, additional, Orlandi, Giovanni, additional, Perini, Francesco, additional, Marcello, Norina, additional, Nucera, Antonia, additional, Massaro, Francesca, additional, DeLodovici, Maria Luisa, additional, Bono, Giorgio, additional, Sessa, Maria, additional, Abbate, Rosanna, additional, and Inzitari, Domenico, additional
- Published
- 2015
- Full Text
- View/download PDF
37. Determinants of premature familial arterial thrombosis in patients with juvenile ischaemic stroke
- Author
-
Pezzini, Alessandro, primary, Grassi, Mario, primary, Lodigiani, Corrado, primary, Patella, Rosalba, primary, Gandolfo, Carlo, primary, Zini, Andrea, primary, DeLodovici, Maria Luisa, primary, Paciaroni, Maurizio, primary, Del Sette, Massimo, primary, Toriello, Antonella, primary, Musolino, Rossella, primary, Calabrò, Rocco Salvatore, primary, Bovil, Paolo, primary, Adami, Alessandro, primary, Silvestrelli, Giorgio, primary, Sessa, Maria, primary, Cavallini, Anna, primary, Marcheselli, Simona, primary, Bonifati, Domenico Marco, primary, Checcarelli, Nicoletta, primary, Tancredi, Lucia, primary, Chiti, Alberto, primary, Del Zotto, Elisabetta, primary, Spalloni, Alessandra, primary, Costa, Paolo, primary, Giacalone, Giacomo, primary, Ferrazzi, Paola, primary, Poli, Loris, primary, Andrea, Morotti, primary, Maurizia, Rasura, primary, Simone, Anna Maria, primary, Gamba, Massimo, primary, Cerrato, Paolo, primary, Micieli, Giuseppe, primary, Melis, Maurizio, primary, Massucco, Davide, primary, De Giuli, Valeria, primary, Pepe, Daniele, primary, Iacoviello, Licia, primary, and Padovani, Alessandro, additional
- Published
- 2015
- Full Text
- View/download PDF
38. Association Between Migraine and Cervical Artery Dissection: The Italian Project on Stroke in Young Adults.
- Author
-
De Giuli, Valeria, Grassi, Mario, Lodigiani, Corrado, Patella, Rosalba, Zedde, Marialuisa, Gandolfo, Carlo, Zini, Andrea, DeLodovici, Maria Luisa, Paciaroni, Maurizio, Del Sette, Massimo, Azzini, Cristiano, Toriello, Antonella, Musolino, Rossella, Salvatore Calabrò, Rocco, Bovi, Paolo, Sessa, Maria, Adami, Alessandro, Silvestrelli, Giorgio, Cavallini, Anna, and Marcheselli, Simona
- Published
- 2017
- Full Text
- View/download PDF
39. Predictors of Long-Term Recurrent Vascular Events After Ischemic Stroke at Young Age
- Author
-
Pezzini, Alessandro, primary, Grassi, Mario, additional, Lodigiani, Corrado, additional, Patella, Rosalba, additional, Gandolfo, Carlo, additional, Zini, Andrea, additional, DeLodovici, Maria Luisa, additional, Paciaroni, Maurizio, additional, Del Sette, Massimo, additional, Toriello, Antonella, additional, Musolino, Rossella, additional, Calabrò, Rocco Salvatore, additional, Bovi, Paolo, additional, Adami, Alessandro, additional, Silvestrelli, Giorgio, additional, Sessa, Maria, additional, Cavallini, Anna, additional, Marcheselli, Simona, additional, Bonifati, Domenico Marco, additional, Checcarelli, Nicoletta, additional, Tancredi, Lucia, additional, Chiti, Alberto, additional, Del Zotto, Elisabetta, additional, Spalloni, Alessandra, additional, Giossi, Alessia, additional, Volonghi, Irene, additional, Costa, Paolo, additional, Giacalone, Giacomo, additional, Ferrazzi, Paola, additional, Poli, Loris, additional, Morotti, Andrea, additional, Rasura, Maurizia, additional, Simone, Anna Maria, additional, Gamba, Massimo, additional, Cerrato, Paolo, additional, Micieli, Giuseppe, additional, Melis, Maurizio, additional, Massucco, Davide, additional, De Giuli, Valeria, additional, Iacoviello, Licia, additional, and Padovani, Alessandro, additional
- Published
- 2014
- Full Text
- View/download PDF
40. Cerebral sinus thrombosis in ulcerative colitis
- Author
-
Casella, Giovanni, primary, Spreafico, Chiara, additional, Costantini, Marilena, additional, Pagni, Fabio, additional, Cortelezzi, Claudio Camillo, additional, Baldini, Vittorio, additional, DeLodovici, Maria Luisa, additional, and Bono, Giorgio, additional
- Published
- 2011
- Full Text
- View/download PDF
41. Clinical value of the pudendal somatosensory evoked potential
- Author
-
Delodovici, Maria Luisa, primary and Fowler, Clare J., additional
- Published
- 1995
- Full Text
- View/download PDF
42. A rare association of early-onset inclusion body myositis, rheumatoid arthritis and autoimmune thyroiditis: a case report and literature review.
- Author
-
Clerici, Angelo Maurizio, Bono, Giorgio, Delodovici, Maria Luisa, Azan, Gaetano, Cafasso, Giuseppina, and Micieli, Giuseppe
- Published
- 2013
43. Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy.
- Author
-
Pezzini A, Tarantino B, Zedde ML, Marcheselli S, Silvestrelli G, Ciccone A, Delodovici ML, Princiotta Cariddi L, Vidale S, Paciaroni M, Azzini C, Padroni M, Gamba M, Magoni M, Del Sette M, Tassi R, de Franco IG, Cavallini A, Calabrò RS, Cappellari M, Giorli E, Giacalone G, Lodigiani C, Zenorini M, Valletta F, Pascarella R, Abrignani G, Castellini P, Genovese A, Latte L, Trapasso MC, Grisendi I, Assenza F, Napoli M, Moratti C, Beccattini S, Acampa M, Valzania F, Grassi M, and Gentilini D
- Abstract
Background: Whether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain., Methods: In the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding., Results: 1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17)., Conclusions: Statin use appears to be unrelated to the risk of ICH recurrence., Competing Interests: Competing interests: AC reports grants from Daiichi-Sankyo; grants from Italfarmaco; and grants from Alexion Pharmaceuticals. MP reports compensation from SANOFI-AVENTIS US LLC for other services; compensation from PFIZER CANADA for other services; compensation from iRhythm Technologies for other services; compensation from Daiichi Sankyo Europe GmbH for other services; and compensation from Bristol-Myers Squibb for other services. The other authors have nothing to disclose., (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
- Published
- 2024
- Full Text
- View/download PDF
44. History of Migraine and Volume of Brain Infarcts: The Italian Project on Stroke at Young Age (IPSYS).
- Author
-
De Giuli V, Besana M, Grassi M, Zedde M, Zini A, Lodigiani C, Marcheselli S, Cavallini A, Micieli G, Rasura M, DeLodovici ML, Tomelleri G, Checcarelli N, Chiti A, Giorli E, Sette MD, Tancredi L, Toriello A, Braga M, Morotti A, Poli L, Caria F, Gamba M, Patella R, Spalloni A, Simone AM, Pascarella R, Beretta S, Fainardi E, Padovani A, Gasparotti R, and Pezzini A
- Abstract
Background and Purpose: Migraine has been shown to increase cerebral excitability, promote rapid infarct expansion into tissue with perfusion deficits, and result in larger infarcts in animal models of focal cerebral ischemia. Whether these effects occur in humans has never been properly investigated., Methods: In a series of consecutive patients with acute ischemic stroke, enrolled in the setting of the Italian Project on Stroke at Young Age, we assessed acute as well as chronic infarct volumes by volumetric magnetic resonance imaging, and compared these among different subgroups identified by migraine status., Results: A cohort of 591 patients (male, 53.8%; mean age, 37.5±6.4 years) qualified for the analysis. Migraineurs had larger acute infarcts than non-migraineurs (median, 5.9 cm3 [interquartile range (IQR), 1.4 to 15.5] vs. 2.6 cm3 [IQR, 0.8 to 10.1], P<0.001), and the largest volumes were observed in patients with migraine with aura (median, 9.0 cm3 [IQR, 3.4 to 16.6]). In a linear regression model, migraine was an independent predictor of increased log (acute infarct volumes) (median ratio [MR], 1.64; 95% confidence interval [CI], 1.22 to 2.20), an effect that was more prominent for migraine with aura (MR, 2.92; 95% CI, 1.88 to 4.54)., Conclusion: s These findings reinforce the experimental observation of larger acute cerebral infarcts in migraineurs, extend animal data to human disease, and support the hypothesis of increased vulnerability to ischemic brain injury in people suffering migraine.
- Published
- 2019
- Full Text
- View/download PDF
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.