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This article discusses a case study of a 72-year-old man with essential thrombocythemia who was diagnosed with mature plasmacytoid dendritic cell proliferation (MPDCP) associated with acute myeloid leukemia (AML). The patient presented with symptoms such as dizziness, night sweats, and weight loss. The diagnosis was confirmed through bone marrow examination and flow cytometric analysis. The article also mentions the classification of neoplasms involving plasmacytoid dendritic cells (pDCs) and the need for further research on the immunophenotype and genomic landscape of pDC-AML. [Extracted from the article]

Objective: To examine the symptoms experienced and the change in driving habits in individuals with concussion. Materials and methods: A survey was created by a team of rehabilitation professionals who see persons with concussion in their clinics. The survey captured demographics, mechanism of injury, date of injury, symptoms experienced during driving, if drivers felt safe when driving, and changes in driving habits since the concussion. Non-parametric tests were used to compare symptoms experienced and driving habits across three groups which were created based on time since injury. Results: Of the 140 participants, 74% (104/140) had resumed driving after concussion; of these 27% (28/104) reported that they felt unsafe while driving. Forty-four per cent (46/104) experienced symptoms while driving, of which headache, and difficulty concentrating were the most common symptoms experienced throughout the concussion spectrum (acute to chronic phase). Most drivers (78/104, 75%) with concussion had changed their driving habits by driving less often and shorter distances, and by avoiding nighttime driving and heavy traffic areas. Conclusions: Headache and concentration problems were experienced by drivers regardless of the time since injury. Most drivers had made changes to their driving habits. Clinicians should consider the symptom burden patients experience and discuss driving restrictions to ensure driving safety. [ABSTRACT FROM AUTHOR]

Purpose: To identify clinical concussion assessment outcomes that uniquely capture simulated driving performance among acutely concussed individuals, relative to controls., Methods: Cross-sectional design. Twenty-eight college students within 72-hours of concussion and 46 non-concussed controls participated in the study. We collected the following clinical concussion assessment outcomes: 4 concussion symptom clusters, 7 computerized neurocognitive domain scores, Standardized Assessment of Concussion (SAC) total score, Balance Error Scoring System total score, and tandem gait completion time. The following simulated driving outcomes were included (count): total collisions, speed exceedances, centerline crossings, and road edge excursions. We used separate generalized linear mixed regression models fit using a Poisson distribution with group, assessment, and interaction effects., Results: Higher migrainous symptoms (p < 0.001), cognitive-fatigue symptoms (p = 0.041), poorer visual memory (p = 0.015), and slower reaction time (p = 0.023) in concussion group were associated with higher risk of committing speed exceedances, relative to controls. Conversely, better performance on the continuous performance test (p = 0.046) and SAC (p = 0.045) in concussion group were associated with higher risk of committing speed exceedances relative to controls. Poorer performance on psychomotor speed (p = 0.001), reaction time (p = 0.031), cognitive flexibility (p = 0.004), and executive function (p = 0.003) were associated with higher risk of committing centerline crossings in concussion group, relative to controls. Conversely, better performance on the continuous performance test (p = 0.035) and higher affective symptoms (p = 0.013) were associated with higher risk of committing centerline crossings and road edge excursions, respectively. relative to controls., Conclusions: Our results highlight key symptom clusters and computerized neurocognitive outcomes that uniquely inform poorer simulated driving performance in acutely concussed individuals. Symptom clusters and computerized neurocognitive function might be helpful when discussing with patients about return to driving decisions post-concussion., Competing Interests: Conflict of Interest and Funding Source: The research reported in the manuscript was supported by Andee’s Army Foundation and the National Center for Advancing Translational Sciences of the NIH under Award Number UL1TR002378. The content is solely the responsibility of authors and does not necessarily represent the official views of the NIH. The authors have no conflict of interest to disclose., (Copyright © 2024 by the American College of Sports Medicine.)