115 results on '"Engler, Daniel"'
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2. Can the Financial Sector Protect the Climate? The Potential of Sustainable Finance
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Lessmann, Kai, Schütze, Franziska, von Dulong, Angelika, Engler, Daniel, Gutsche, Gunnar, Hagen, Achim, Klein, Christian, McConnell, Andrew, Schenker, Oliver, von Schickfus, Marie Theres, Yanovski, Boyan, Wendt, Karen, Series Editor, Rammerstorfer, Margarethe, Series Editor, and Villhauer, Bernd, editor
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- 2024
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3. On the relationship between corporate CO2 offsetting and pro-environmental activities in small- and medium-sized firms in Germany
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Engler, Daniel, Gutsche, Gunnar, Simixhiu, Amantia, and Ziegler, Andreas
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- 2023
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4. The budget impact of implementing atrial fibrillation-screening in European countries
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Eklund, Michaela, Bernfort, Lars, Appelberg, Kajsa, Engler, Daniel, Schnabel, Renate B, Martinez, Carlos, Wallenhorst, Christopher, Boriani, Giuseppe, Buckley, Claire M, Diederichsen, Søren Zöga, Svendsen, Jesper Hastrup, Montaner, Joan, Potpara, Tatjana, Levin, Lars-Åke, Lyth, Johan, Eklund, Michaela, Bernfort, Lars, Appelberg, Kajsa, Engler, Daniel, Schnabel, Renate B, Martinez, Carlos, Wallenhorst, Christopher, Boriani, Giuseppe, Buckley, Claire M, Diederichsen, Søren Zöga, Svendsen, Jesper Hastrup, Montaner, Joan, Potpara, Tatjana, Levin, Lars-Åke, and Lyth, Johan
- Abstract
A budget impact analysis estimates the short-term difference between the cost of the current treatment strategy and a new treatment strategy, in this case to implement population screening for atrial fibrillation (AF). The aim of this study is to estimate the financial impact of implementing population-based AF-screening of 75-year-olds compared with the current setting of no screening from a healthcare payer perspective in eight European countries. The net budget impact of AF-screening was estimated in country-specific settings for Denmark, Germany, Ireland, Italy, Netherlands, Serbia, Spain, and Sweden. Country-specific parameters were used to allow for variations in healthcare systems and to reflect the healthcare sector in the country of interest. Similar results can be seen in all countries AF-screening incurs savings of stroke-related costs since AF treatment reduces the number of strokes. However, the increased number of detected AF and higher drug acquisition will increase the drug costs as well as the costs of physician- and control visits. The net budget impact per invited varied from 10 in Ireland to 122 in the Netherlands. The results showed the increased costs of implementing AF-screening were mainly driven by increased drug costs and screening costs. In conclusion, across Europe, though the initial cost of screening and more frequent use of oral anti-coagulants will increase the healthcare payers' costs, introducing population screening for AF will result in savings of stroke-related costs., Funding Agencies|This work has received funding from the European Union's Horizon 2020 research and innovation programme under the grant agreement No 847770 (AFFECT-EU). Data from the LOOP Study was used and LOOP was supported by Innovation Fund Denmark [grant number 12-1352259], The Research Foundation for the Capital Region of Denmark, The Danish Heart Foundation [grant number 11-04-R83-A3363-22625], Aalborg University Talent Management Program, Arvid Nilssons Fond, Skibsreder Per Henriksen, Rog Hustrus Fond, the European Union's Horizon 2020 program [grant number 847770 to the AFFECT-EU consortium], Laege Sophus Carl Emil Friis og hustru Olga Doris Friis' Legat, and an unrestricted grant from Medtronic. R.B.S. has received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme under the grant agreement No 648131, from the European Union's Horizon 2020 research and innovation programme under the grant agreement No 847770 (AFFECT-EU) and German Center for Cardiovascular Research (DZHK e.V.) (81Z1710103 and 81Z0710114); German Ministry of Research and Education (BMBF 01ZX1408A) and ERACoSysMed3 (031L0239). Wolfgang Seefried project funding German Heart Foundation. From the European Union's Horizon Europe research and innovation programme under the grant agreement No. 101095480 (HYPERMAKER) DAS:Data available on request.
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- 2024
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5. Sex Differences in Prevalent Cardiovascular Disease in the General Population
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Engler, Daniel, Makarova, Natascha, Schnabel, Renate B., Hecker, Markus, Editor-in-Chief, Backs, Johannes, Series Editor, Freichel, Marc, Series Editor, Korff, Thomas, Series Editor, Thomas, Dierk, Series Editor, Erdmann, Jeanette, editor, and Moretti, Alessandra, editor
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- 2019
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6. The Effects of Norms on Environmental Behavior
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Dannenberg, Astrid, primary, Gutsche, Gunnar, additional, Batzke, Marlene C. L., additional, Christens, Sven, additional, Engler, Daniel, additional, Mankat, Fabian, additional, Möller, Sophia, additional, Weingärtner, Eva, additional, Ernst, Andreas, additional, Lumkowsky, Marcel, additional, Wangenheim, Georg von, additional, Hornung, Gerrit, additional, and Ziegler, Andreas, additional
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- 2024
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7. Increased risk of dementia differs across cardiovascular diseases and types of dementia – Data from a nationwide study
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Kauko, Anni, primary, Engler, Daniel, additional, Niiranen, Teemu, additional, Ortega‐Alonso, Alfredo, additional, and Schnabel, Renate B., additional
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- 2023
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8. The expressive effect of legal norms on sustainable consumption
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Möller, Sophia, primary, Engler, Daniel, additional, Gleue, Marvin, additional, Gutsche, Gunnar, additional, and Ziegler, Andreas, additional
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- 2023
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9. Screening for atrial fibrillation: the role of CHA2DS2-VASc and atrial fibrillation burden
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Xing, Lucas Yixi, Vad, Oliver B, Engler, Daniel, Svendsen, Jesper H, and Diederichsen, Søren Z
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Individuals with subclinical atrial fibrillation (AF) face an increased risk of thromboembolic events, which may potentially be mitigated through AF screening and subsequent anticoagulation. However, data from randomized clinical trials (RCTs) indicate a lower stroke risk in subclinical AF compared with the clinical phenotype. This—along with the inherent bleeding risk related to anticoagulation—seems to render the net clinical benefit of AF screening less evident. Further, current guidelines recommend consideration of CHA2DS2-VASc score and AF episode duration to guide screening and treatment. These recommendations, in general, lack support and seem questionable in view of the limited RCT data. More evidence is warranted to provide insights into the potential benefits of screening and treatment of screen-detected AF in specific population subgroups and AF phenotypes.
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- 2024
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10. Increased risk of dementia differs across cardiovascular diseases and types of dementia – Data from a nationwide study.
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Kauko, Anni, Engler, Daniel, Niiranen, Teemu, Ortega‐Alonso, Alfredo, and Schnabel, Renate B.
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CARDIOVASCULAR diseases , *HEART failure , *DISEASE risk factors , *TRANSIENT ischemic attack , *ALZHEIMER'S disease , *DEMENTIA - Abstract
Aims: Dementia is a major health problem. Cardiovascular diseases (CVD) and risk factors are associated with incident dementia. However, whether there is an association among CVD, Alzheimer's disease (AD) and vascular dementia (VD) at the population level remains unclear. Methods: We analysed the association between CVD (heart failure [HF], atrial fibrillation [AF], myocardial infarction [MI], peripheral arterial disease, stroke and transient ischemic attack) and the incidence of dementia using nationwide FinnGen data of 218,192 individuals. The last follow‐up information on dementia was available from October 2021. Results: The age at the end of the follow‐up was 61.7 ± 17.1 years, and 53% were women. Overall, we observed 9701 (4.4%) dementia, 6323 (2.9%) AD and 1918 (0.7%) VD cases. Individuals with CVD had a higher risk of developing dementia than unexposed individuals. In the multivariable‐adjusted Cox models, stroke was most strongly associated with dementia (hazard ratio [HR] 1.7, 95% confidence interval [CI] 1.6–1.8). CVD was more strongly associated with VD than with AD. Individuals with HF and MI had an increased risk of AD (HF: HR 1.11, 95% CI 1.04–1.19; MI: HR 1.10, 95% CI 1.02–1.18). AF was associated with VD (HR 1.58, 95% CI 1.42–1.77), but not with AD (HR 1.03, 95% CI 0.97–1.09). Clinical characteristics, such as diabetes, smoking and alcohol abuse, were associated with both types of dementia. Conclusion: All major CVDs were associated with an increased risk of developing dementia, particularly VD. Therefore, CVD onset should prompt an assessment of cognitive decline and possible preventive measures. [ABSTRACT FROM AUTHOR]
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- 2024
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11. General practitioners’ perceptions on opportunistic single-time point screening for atrial fibrillation: A European quantitative survey
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Vermunicht, Paulien, Grecu, Mihaela, Deharo, Jean-Claude, Buckley, Claire M, Palà, Elena, Mairesse, Georges H, Farkowski, Michal M, Bergonti, Marco, Pürerfellner, Helmut, Hanson, Coral L, Neubeck, Lis, Freedman, Ben, Witt, Henning, Hills, Mellanie T, Lund, Jenny, Giskes, Katrina, Engler, Daniel, Schnabel, Renate B, Heidbuchel, Hein, Desteghe, Lien, AFFECT-EU investigators, Apollo - University of Cambridge Repository, AFFECT-EU Investigators, Vermunicht, Paulien, Grecu, Mihaela, Deharo, Jean-Claude, Buckley, Claire M., Pala, Elena, Mairesse, Georges H., Farkowski, Michal M., Bergonti, Marco, Puererfellner, Helmut, Hanson, Coral L., Neubeck, Lis, Freedman, Ben, Witt, Henning, Hills, Mellanie T., Lund, Jenny, Giskes, Katrina, Engler, Daniel, Schnabel, Renate B., HEIDBUCHEL, Hein, DESTEGHE, Lien, AFFECT-EU investigators, Institut Català de la Salut, [Vermunicht P] Department of Cardiology, Antwerp University Hospital, Antwerp, Belgium. Research Group Cardiovascular Diseases, University of Antwerp, Antwerp, Belgium. [Grecu M] Electrophysiology Department, Cardiovascular Diseases Institute, Iasi, Romania. [Deharo JC] Assistance Publique − Hôpitaux de Marseille and Aix Marseille Université, C2VN, Marseille, France. [Buckley CM] School of Public Health, University College Cork, Cork, Ireland. [Palà E] Laboratori de Recerca Neurovascular, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Mairesse GH] Cliniques du Sud Luxembourg, Arlon, Belgium, and Vall d'Hebron Barcelona Hospital Campus
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Investigative Techniques::Epidemiologic Methods::Data Collection::Surveys and Questionnaires [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,screening ,enfermedades cardiovasculares::enfermedades cardíacas::arritmias cardíacas::fibrilación atrial [ENFERMEDADES] ,Otros calificadores::/diagnóstico [Otros calificadores] ,técnicas de investigación::métodos epidemiológicos::recopilación de datos::encuestas y cuestionarios [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,Diagnosis::Diagnostic Techniques and Procedures::Mass Screening [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT] ,Atrial fibrillation ,Enquestes ,AFFECT-EU ,Fibril·lació auricular - Diagnòstic ,general practitioners ,General practitioners ,Screening ,Cribatge (Medicina) ,Other subheadings::/diagnosis [Other subheadings] ,diagnóstico::técnicas y procedimientos diagnósticos::cribado sistemático [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS] ,atrial fibrillation ,survey ,Human medicine ,Survey ,Cardiology and Cardiovascular Medicine ,Cardiovascular Diseases::Heart Diseases::Arrhythmias, Cardiac::Atrial Fibrillation [DISEASES] - Abstract
Peer reviewed: True, Acknowledgements: The authors thank the survey participants for their generous contribution of time and effort. We also thank our contact persons for their essential support in making the distribution of the survey possible., BACKGROUND: There is no clear guidance on how to implement opportunistic atrial fibrillation (AF) screening in daily clinical practice. OBJECTIVES: This study evaluated the perception of general practitioners (GPs) about value and practicalities of implementing screening for AF, focusing on opportunistic single-time point screening with a single-lead electrocardiogram (ECG) device. METHODS: A descriptive cross-sectional study was conducted with a survey developed to assess overall perception concerning AF screening, feasibility of opportunistic single-lead ECG screening and implementation requirements and barriers. RESULTS: A total of 659 responses were collected (36.1% Eastern, 33.4% Western, 12.1% Southern, 10.0% Northern Europe, 8.3% United Kingdom & Ireland). The perceived need for standardized AF screening was rated as 82.7 on a scale from 0 to 100. The vast majority (88.0%) indicated no AF screening program is established in their region. Three out of four GPs (72.1%, lowest in Eastern and Southern Europe) were equipped with a 12-lead ECG, while a single-lead ECG was less common (10.8%, highest in United Kingdom & Ireland). Three in five GPs (59.3%) feel confident ruling out AF on a single-lead ECG strip. Assistance through more education (28.7%) and a tele-healthcare service offering advice on ambiguous tracings (25.2%) would be helpful. Preferred strategies to overcome barriers like insufficient (qualified) staff, included integrating AF screening with other healthcare programs (24.9%) and algorithms to identify patients most suitable for AF screening (24.3%). CONCLUSION: GPs perceive a strong need for a standardized AF screening approach. Additional resources may be required to have it widely adopted into clinical practice.
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- 2023
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12. Sex Differences in Prevalent Cardiovascular Disease in the General Population
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Engler, Daniel, primary, Makarova, Natascha, additional, and Schnabel, Renate B., additional
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- 2019
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13. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation : the 8th AFNET/EHRA consensus conference
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Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, Kirchhof, Paulus, Schnabel, Renate B, Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M, Camm, A John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Søren Zöga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stéphane N, Haeusler, Karl Georg, Healey, Jeff S, Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F D Richard, Hübner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y H, Løchen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L, Meyer, Ralf, Mont, Lluıs, Myers, Michael C, Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S, Psaroudakis, George, Pürerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F, Smolnik, Rüdiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, True Hills, Mellanie, van Gelder, Isabelle C, Vardar, Burcu, Palà, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, André, Daniel Zink, Matthias, and Kirchhof, Paulus
- Abstract
Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
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- 2023
- Full Text
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14. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation:the 8th AFNET/EHRA consensus conference
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Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, Kirchhof, Paulus, Schnabel, Renate B., Marinelli, Elena Andreassi, Arbelo, Elena, Boriani, Giuseppe, Boveda, Serge, Buckley, Claire M., Camm, A. John, Casadei, Barbara, Chua, Winnie, Dagres, Nikolaos, de Melis, Mirko, Desteghe, Lien, Diederichsen, Soren Zoga, Duncker, David, Eckardt, Lars, Eisert, Christoph, Engler, Daniel, Fabritz, Larissa, Freedman, Ben, Gillet, Ludovic, Goette, Andreas, Guasch, Eduard, Svendsen, Jesper Hastrup, Hatem, Stephane N., Haeusler, Karl Georg, Healey, Jeff S., Heidbuchel, Hein, Hindricks, Gerhard, Hobbs, F. D. Richard, Huebner, Thomas, Kotecha, Dipak, Krekler, Michael, Leclercq, Christophe, Lewalter, Thorsten, Lin, Honghuang, Linz, Dominik, Lip, Gregory Y. H., Lochen, Maja Lisa, Lucassen, Wim, Malaczynska-Rajpold, Katarzyna, Massberg, Steffen, Merino, Jose L., Meyer, Ralf, Mont, Lluis, Myers, Michael C., Neubeck, Lis, Niiranen, Teemu, Oeff, Michael, Oldgren, Jonas, Potpara, Tatjana S., Psaroudakis, George, Purerfellner, Helmut, Ravens, Ursula, Rienstra, Michiel, Rivard, Lena, Scherr, Daniel, Schotten, Ulrich, Shah, Dipen, Sinner, Moritz F., Smolnik, Rudiger, Steinbeck, Gerhard, Steven, Daniel, Svennberg, Emma, Thomas, Dierk, Hills, Mellanie True, van Gelder, Isabelle C., Vardar, Burcu, Pala, Elena, Wakili, Reza, Wegscheider, Karl, Wieloch, Mattias, Willems, Stephan, Witt, Henning, Ziegler, Andre, Zink, Matthias Daniel, and Kirchhof, Paulus
- Abstract
Aims Despite marked progress in the management of atrial fibrillation (AF), detecting AF remains difficult and AF-related complications cause unacceptable morbidity and mortality even on optimal current therapy. Methods and results This document summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference of the Atrial Fibrillation NETwork (AFNET) and the European Heart Rhythm Association (EHRA). Eighty-three international experts met in Hamburg for 2 days in October 2021. Results of the interdisciplinary, hybrid discussions in breakout groups and the plenary based on recently published and unpublished observations are summarized in this consensus paper to support improved care for patients with AF by guiding prevention, individualized management, and research strategies. The main outcomes are (i) new evidence supports a simple, scalable, and pragmatic population-based AF screening pathway; (ii) rhythm management is evolving from therapy aimed at improving symptoms to an integrated domain in the prevention of AF-related outcomes, especially in patients with recently diagnosed AF; (iii) improved characterization of atrial cardiomyopathy may help to identify patients in need for therapy; (iv) standardized assessment of cognitive function in patients with AF could lead to improvement in patient outcomes; and (v) artificial intelligence (AI) can support all of the above aims, but requires advanced interdisciplinary knowledge and collaboration as well as a better medico-legal framework. Conclusions Implementation of new evidence-based approaches to AF screening and rhythm management can improve outcomes in patients with AF. Additional benefits are possible with further efforts to identify and target atrial cardiomyopathy and cognitive impairment, which can be facilitated by AI.
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- 2023
15. Sex-Specific Dietary Patterns and Social Behaviour in Low-Risk Individuals
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Engler, Daniel, primary, Schnabel, Renate B., additional, Neumann, Felix Alexander, additional, Zyriax, Birgit-Christiane, additional, and Makarova, Nataliya, additional
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- 2023
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16. Why Do Investors Pay Higher Fees for Sustainable Investments? An Experiment in Five European Countries
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Engler, Daniel, primary, Gutsche, Gunnar, additional, and Smeets, Paul, additional
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- 2023
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17. Early detection of atrial fibrillation in the digital era, risk factors, treatment options, and the need for new definitions
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Schnabel, Renate B, Engler, Daniel, and Freedman, Ben
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Graphical abstract
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- 2024
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18. Individual preferences for sustainable investments across Europe – A framed field experiment in five countries
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Engler, Daniel, Gutsche, Gunnar, and Smeets, Paul
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Behavioral Economics ,Cross-country analysis ,Incentivized investment experiment ,Individual investors ,Economics ,Sustainable investments ,Framed field experiment ,Social and Behavioral Sciences ,Finance - Abstract
To understand the extent to which individual preferences towards sustainable and especially climate-related investments vary across countries, we are going to conduct an incentivized framed field experiment in five European countries during May and June 2021. We also in-vestigate the importance of different motives for sustainable investments across countries. The experiment is part of a survey of households’ financial decision-makers in France, Germany, the Netherlands, Poland, and Spain, with about 1,000 respondents per country. Our experimental design enables us to calculate the amount of additional fees respondents are willing to pay in order to invest in exchange traded index funds based on the MSCI World ESG Screened Index and the MSCI World Climate Change Index. This allows us to compare not only preferences for sustainable investments across different countries, but also in terms of the thematic focus of sustainable funds. Following Riedl and Smeets (2017), we also analyze to what extent the relevance of pecuniary motives, social signaling, and social prefer-ences for sustainable investment decisions varies across countries. Thus, this study is the first to compare preferences for sustainable investments at the individual level across different countries, while providing identical information and choices to individuals.
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- 2022
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19. Is there a hypothetical gap in experiments on the willingness to pay for sustainable funds?
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Engler, Daniel, Gutsche, Gunnar, and Ziegler, Andreas
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Behavioral Economics ,Incentivized investment experiment ,Individual investors ,Economics ,Sustainable investments ,Framed field experiment ,Social and Behavioral Sciences ,Finance - Abstract
We analyze the determinants of hypothetical bias in choice experiments for sustainable investments (SRI). To this end, we compare participants’ willingness to pay derived from incentivized and stated decisions in discrete choice experiments conducted among households’ financial decision makers in Germany. We further extend the set of potential determinants of differences between incentivized and hypothetical choices with the Big Five personality traits. In particular, we analyze the role of extraversion, conscientiousness, and openness to experience, as those traits have been shown to be related to how people react to (monetary) incentives. Our results allow us to shed light on the reliability of previous stated choice analyses in this field and to provide guidance for future experiments.
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- 2022
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20. Feasible approaches and implementation challenges to atrial fibrillation screening: A qualitative study of stakeholder views in eleven European countries
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Hanson, Coral, Potpara, Tatjana S, Witt, Henning, Heidbuchel, Hein, Engler, Daniel, Desteghe, Lien, Boriani, Guiseppe, Diederichsen, Soren Zoga, Freedman, Ben, Pala, Elena, Neubeck, Lis, and Schnabel, Renate
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Centre for Cardiovascular Health ,Health ,eHealth ,screening, atrial fibrillation, qualitative research ,Long-Term Conditions Research Group - Abstract
Objectives: Atrial fibrillation (AF) screening may increase early detection and reduce complications of AF. European, Australian and World Heart Federation guidelines recommend opportunistic screening, despite a current lack of clear evidence supporting a net benefit for systematic screening. Where screening is implemented, the most appropriate approaches are unknown. We explored the views of European stakeholders about opportunities and challenges of implementing four AF screening scenarios.Design: Telephone-based semi-structured interviews with results reported using Consolidated criteria for Reporting Qualitative research guidelines. Data were thematically analysed using the framework approach.Setting: AF screening stakeholders in 11 European countries.Participants: Healthcare professionals and regulators (n=24) potentially involved in AF screening implementation.Intervention: Four AF screening scenarios: single time point opportunistic, opportunistic prolonged, systematic single time point/prolonged and patient-led screening.Primary outcome measures: Stakeholder views about the challenges and feasibility of implementing the screening scenarios in the respective national/regional healthcare system.Results: Three themes developed. (1) Current screening approaches: there are no national AF screening programmes, with most AF detected in symptomatic patients. Patient-led screening exists via personal devices, creating screening inequity. (2) Feasibility of screening: single time point opportunistic screening in primary care using single-lead ECG devices was considered the most feasible. Software algorithms may aid identification of suitable patients and telehealth services have potential to support diagnosis. (3) Implementation requirements: sufficient evidence of benefit is required. National screening processes are required due to different payment mechanisms and health service regulations. Concerns about data security, and inclusivity for those without primary care access or personal devices must be addressed.Conclusions: There is an overall awareness of AF screening. Opportunistic screening appears the most feasible across Europe. Challenges are health inequalities, identification of best target groups for screening, streamlined processes, the need for evidence of benefit and a tailored approach adapted to national realities.
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- 2022
21. Framework for Operational Resilience Management of Critical Infrastructures and Organizations
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Engler, Daniel Lichte, Frank Sill Torres, and Evelin
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resilience ,risk ,resilience management ,digital twin ,uncertainties ,operational framework - Abstract
Progressing digitalization and networking of systems and organizations representing Critical Infrastructures opens promising new potentials and opportunities, which on the downside, are accompanied by rising complexity and increasingly opaque interdependencies. The consequently increasing lack of knowledge leads to uncertainties affecting risk assessment and decision-making in case of adverse events. This trend motivated recent discussions and developments in risk science, emphasizing the need to handle such uncertainties. Complementarily, research in the resilience domain focuses on system capabilities to handle surprising hazardous situations. Several frameworks presented in the literature aim at combining both perspectives but either lack the focus on operational management, have a rather theoretical approach, or are designed for specific applications. Based on this observation, we propose an approach that integrates resilience management into the actual operation of Critical Infrastructure Systems and Organizations by providing an operational process that coordinates the fundamental resilience capabilities of responding, monitoring, anticipation, and learning. Furthermore, we tackle the challenge of uncertainties resulting from a lack of knowledge by aligning the concepts of digital twin and resilience management. The proposed framework is extensively discussed, and required processes are presented in detail. Eventually, its applicability and potential are reviewed by means of a complex hazardous situation at a Bavarian district heating power plant.
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- 2022
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22. Early diagnosis and better rhythm management to improve outcomes in patients with atrial fibrillation: the 8th AFNET/EHRA consensus conference
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Schnabel, Renate B, primary, Marinelli, Elena Andreassi, additional, Arbelo, Elena, additional, Boriani, Giuseppe, additional, Boveda, Serge, additional, Buckley, Claire M, additional, Camm, A John, additional, Casadei, Barbara, additional, Chua, Winnie, additional, Dagres, Nikolaos, additional, de Melis, Mirko, additional, Desteghe, Lien, additional, Diederichsen, Søren Zöga, additional, Duncker, David, additional, Eckardt, Lars, additional, Eisert, Christoph, additional, Engler, Daniel, additional, Fabritz, Larissa, additional, Freedman, Ben, additional, Gillet, Ludovic, additional, Goette, Andreas, additional, Guasch, Eduard, additional, Svendsen, Jesper Hastrup, additional, Hatem, Stéphane N, additional, Haeusler, Karl Georg, additional, Healey, Jeff S, additional, Heidbuchel, Hein, additional, Hindricks, Gerhard, additional, Hobbs, F D Richard, additional, Hübner, Thomas, additional, Kotecha, Dipak, additional, Krekler, Michael, additional, Leclercq, Christophe, additional, Lewalter, Thorsten, additional, Lin, Honghuang, additional, Linz, Dominik, additional, Lip, Gregory Y H, additional, Løchen, Maja Lisa, additional, Lucassen, Wim, additional, Malaczynska-Rajpold, Katarzyna, additional, Massberg, Steffen, additional, Merino, Jose L, additional, Meyer, Ralf, additional, Mont, Lluıs, additional, Myers, Michael C, additional, Neubeck, Lis, additional, Niiranen, Teemu, additional, Oeff, Michael, additional, Oldgren, Jonas, additional, Potpara, Tatjana S, additional, Psaroudakis, George, additional, Pürerfellner, Helmut, additional, Ravens, Ursula, additional, Rienstra, Michiel, additional, Rivard, Lena, additional, Scherr, Daniel, additional, Schotten, Ulrich, additional, Shah, Dipen, additional, Sinner, Moritz F, additional, Smolnik, Rüdiger, additional, Steinbeck, Gerhard, additional, Steven, Daniel, additional, Svennberg, Emma, additional, Thomas, Dierk, additional, True Hills, Mellanie, additional, van Gelder, Isabelle C, additional, Vardar, Burcu, additional, Palà, Elena, additional, Wakili, Reza, additional, Wegscheider, Karl, additional, Wieloch, Mattias, additional, Willems, Stephan, additional, Witt, Henning, additional, Ziegler, André, additional, Daniel Zink, Matthias, additional, and Kirchhof, Paulus, additional
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- 2022
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23. Feasible approaches and implementation challenges to atrial fibrillation screening: a qualitative study of stakeholder views in 11 European countries
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Engler, Daniel, primary, Hanson, Coral L, additional, Desteghe, Lien, additional, Boriani, Giuseppe, additional, Diederichsen, Søren Zöga, additional, Freedman, Ben, additional, Palà, Elena, additional, Potpara, Tatjana S, additional, Witt, Henning, additional, Heidbuchel, Hein, additional, Neubeck, Lis, additional, and Schnabel, Renate B, additional
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- 2022
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24. Social norms and individual climate protection activities: A framed field experiment for Germany
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Engler, Daniel, Gutsche, Gunnar, Simixhiu, Amantia, and Ziegler, Andreas
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C93 ,D83 ,heterogeneous treatment effects ,Q54 ,ddc:330 ,D91 ,information interventions ,D64 ,Climate protection activities ,descriptive and injunctive social norms ,framed field experiment - Abstract
Based on the well-known observation that social norms can guide individual behavior, this paper empirically examines the causal effect of related information interventions on revealed climate protection activities, measured through incentivized donations. In our field-experi-mental setting, we differentiate between descriptive social norms by providing information about individual climate protection activities in Germany, injunctive social norms by provid-ing information about what people in Germany think about the need for climate protection activities, and a combination of both social norms. Based on representative survey data for more than 1,600 individuals in Germany, our econometric analysis shows some weak evi-dence that information about both descriptive and injunctive social norms increases donations for climate protection. The decomposition of this estimated average treatment effects reveals that the corresponding treatment particularly has a significantly positive effect at the extensive margin, i.e. on the probability to donate for climate protection. These results suggest that a combined information intervention referring to both descriptive and injunctive social norms is at least able to stimulate the general willingness for climate protection. In addition, our analysis of heterogeneous treatment effects reveals that strong social preferences (in terms of altruism and trust) and high environmental attitudes (in terms of environmental awareness and ecological policy identification) induce significantly positive information treatment effects on donations for climate protection. This result suggests that individuals in Germany with a strong environmental and social orientation do not only behave directly more climate-friendly, but can also be better stimulated by information about descriptive and/or injunctive social norms.
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- 2022
25. Refined atrial fibrillation screening and cost-effectiveness in the German population
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Schnabel, Renate B, primary, Wallenhorst, Christopher, additional, Engler, Daniel, additional, Blankenberg, Stefan, additional, Pfeiffer, Norbert, additional, Spruenker, Ngoc Anh, additional, Buettner, Matthias, additional, Michal, Matthias, additional, Lackner, Karl J, additional, Münzel, Thomas, additional, Wild, Philipp S, additional, Martinez, Carlos, additional, and Freedman, Ben, additional
- Published
- 2021
- Full Text
- View/download PDF
26. Corporate CO2 offsetting in small- and medium-seized firms in Germany
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Engler, Daniel, Gutsche, Gunnar, Simixhiu, Amantia, and Ziegler, Andreas
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ddc:330 ,Corporate CO2 offsetting ,corporate climate protection and pro-environmental activities ,small- and medium-sized firms - Abstract
Voluntary CO2 offsetting by individuals, firms, and organizations is increasingly considered as a direction of climate policy that is complementary to traditional approaches such as sub-sidies or CO2 taxes. Based on data from a large-scale survey among corporate decision mak-ers, this paper empirically examines corporate CO2 offsetting and its determinants in small- and medium-sized firms in Germany. Our descriptive analysis shows both a rather limited engagement in corporate CO2 offsetting as well as a strong lack of knowledge about its mechanism. The econometric analysis reveals that some firm-specific characteristics like the average age of the employees, firm size, and firm age matter for CO2 offsetting. However, the main estimation results refer to the relevance of general environment-related variables like the implementation of environmental product and service innovations or the share of employees that carry out environment-related tasks and especially of climate-related factors and activities. In particular, the implementation of climate targets and the participation in the EU Emissions Trading System (EU ETS) are strongly significantly positively correlated with CO2 offsetting. In line with similar findings at the individual level, these estimation results imply that corporate CO2 offsetting also does not substitute or crowd out other climate pro-tection and further pro-environmental activities, but rather complements them.
- Published
- 2021
27. Trust in institutions and consequentiality perceptions in a stated preference survey
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Engler, Daniel, primary, Gutsche, Gunnar, additional, and Zawojska, Ewa, additional
- Published
- 2021
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28. Digital, risk-based screening for atrial fibrillation in the European community—the AFFECT-EU project funded by the European Union
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Engler, Daniel, primary, Heidbuchel, Hein, additional, and Schnabel, Renate B, additional
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- 2021
- Full Text
- View/download PDF
29. Acceptance of climate-oriented policy measures under the COVID-19 crisis: an empirical analysis for Germany
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Engler, Daniel, primary, Groh, Elke D., additional, Gutsche, Gunnar, additional, and Ziegler, Andreas, additional
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- 2021
- Full Text
- View/download PDF
30. Studying the Incubation of a New Product Market Through Realized and Alternative Histories
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Engler, Daniel, primary, Cattani, Gino, additional, and Porac, Joe, additional
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- 2020
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31. Refined atrial fibrillation screening and cost-effectiveness in the German population.
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Schnabel, Renate B., Wallenhorst, Christopher, Engler, Daniel, Blankenberg, Stefan, Pfeiffer, Norbert, Spruenker, Ngoc Anh, Buettner, Matthias, Michal, Matthias, Lackner, Karl J., Münzel, Thomas, Wild, Philipp S., Martinez, Carlos, Freedman, Ben, and Gutenberg Health Study investigators
- Subjects
STROKE ,TRANSIENT ischemic attack ,ATRIAL fibrillation ,MEDICAL screening ,GERMANS - Abstract
Objective: Little is known on optimal screening population for detecting new atrial fibrillation (AF) in the community. We describe characteristics and estimate cost-effectiveness for a single timepoint electrocardiographic screening.Methods: We performed a 12-lead ECG in the German population-based Gutenberg Health Study between 2007 and 2012 (n=15 010), mean age 55±11 years, 51% men and collected more than 120 clinical and biomarker variables, including N-terminal pro B-type natriuretic peptide (Nt-proBNP), risk factors, disease symptoms and echocardiographic variables.Results: Of 15 010 individuals, 466 (3.1%) had AF. New AF was found in 32 individuals, 0.2% of the total sample, 0.5% of individuals aged 65-74 years and predominantly men (86%). The classical risk factor burden was high in individuals with new AF. The median estimated stroke risk was 2.2%/year, while risk of developing heart failure was 21% over 10 years. In the 65-74 year age group, the cost per quality-adjusted life-year gained resulting from a single timepoint screening was €30 361. In simulations, the costs were highly sensitive to AF detection rates, proportion of treatment and type of oral anticoagulant. Prescreening by Nt-proBNP measurements was not cost-effective in the current setting.Conclusions: In our middle-aged population cohort, we identified 0.2% new AF by single timepoint screening. There was a significant estimated risk of stroke and heart failure in these individuals. Cost-effectiveness for screening may be reached in individuals aged 65 years and older. The simple age cut-off is not improved by using Nt-proBNP as a biomarker to guide a screening programme. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
32. Acceptance of climate-oriented policy measures in times of the COVID-19 crisis
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Engler, Daniel, Groh, Elke D., Gutsche, Gunnar, and Ziegler, Andreas
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climate-oriented economic stimulus programs ,O44 ,Q54 ,H12 ,COVID-19 crisis ,ddc:330 ,Q48 ,climate policy measures ,multivariate probit models ,Q58 ,acceptance - Abstract
Based on data from a representative survey among citizens in Germany during the peak of the COVID-19 crisis, this paper empirically examines the acceptance of climate-oriented economic stimulus programs and several further climate policy measures. Our descriptive analysis shows no general lower acceptance of climate policy measures compared to the time before the crisis. However, the econometric analysis reveals that individuals with higher negative emotions towards the crisis are significantly less supportive of at least some climate-oriented policy measures. Economic concerns are of particular relevance. For example, a perceived deterioration of the general economic situation due to the COVID-19 crisis has a significantly negative effect on the acceptance of climate-oriented economic stimulus programs. Concerns about the own personal economic and financial situation due to the crisis are significantly negatively correlated with the support of climate-oriented policy measures that directly lead to higher costs in daily life. Besides the relevance of this perceived self-interest, our estimation results also highlight the relevance of social aspects since individuals with a social policy identification are significantly more likely to agree with climate-oriented policy measures that are also financially beneficial for socially de-prived groups, but significantly less likely to support measures that are financially unfa-vorable for them. We discuss several climate policy implications. For example, our estima-tion results suggest that successful climate policy should, especially in times of the COVID-19 crisis, also be socially oriented and consider distribution effects, for example, through financial compensations for costly measures like taxes.
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- 2020
33. Is it a car or a truck?: managerial beliefs, the choice of product architecture, and the emergence of the minivan market segment.
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Engler, Daniel E.
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MINIVANS ,MARKET segmentation ,TECHNOLOGICAL innovations ,COMMERCIALIZATION ,ORGANIZATIONAL structure - Abstract
New markets segments are a common setting for studies in technology strategy. These studies generally assume that new segments already exist, or have formed following the introduction of a product innovation by an entering firm. Thus, theory on the role of established firms in the emergence of new market segments is underdeveloped. This study informs current research by explaining the product innovation decisions of established firms during the emergence of a new market segment. The results of a case study on the development and commercialization of the minivan at Chrysler, Ford, and General Motors between 1970 and 1985 indicate that existing theories based on managerial cognition, firm capabilities, economic incentives, and organizational structure are insufficient to explain the decisions. This article develops theory based on the interrelationship of these four mechanisms. [ABSTRACT FROM AUTHOR]
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- 2015
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34. The causal effect of religious and environmental identity on green preferences: A combined priming and stated choice experiment
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Engler, Daniel, Groh, Elke D., and Ziegler, Andreas
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green electricity ,Q42 ,Q54 ,mixed logit models ,religious and environmental identity ,ddc:330 ,Z12 ,Climate change ,C25 ,priming, stated choice experiment ,renewable energy ,A13 - Abstract
Using a stated choice experiment, we find that a prime that makes environmental identity salient makes people behave greener, whereas it does not if it makes religious identity salient. Further-more, we discover non-linear priming effects for environmental identity, which means that rais-ing the salience of highly environmentally oriented respondents or respondents without envi-ronmental identity does not change behavior while it does for respondents with a medium level strength of identity. Methodologically, our study combines for the first time a priming experi-ment with a stated choice (SC) experiment and uses a respondent specific status quo alternative in the empirical analysis with mixed logit models.
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- 2019
35. Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes
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B Schnabel, Renate, primary, Pecen, Ladislav, additional, Engler, Daniel, additional, Lucerna, Markus, additional, Sellal, Jean Marc, additional, Ojeda, Francisco M, additional, De Caterina, Raffaele, additional, and Kirchhof, Paulus, additional
- Published
- 2018
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- View/download PDF
36. The Evolution of System Architectures: Products, Organizations, and Industries
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Engler, Daniel, primary, Lecuona, Ramon, additional, Baldwin, Carliss, additional, Camuffo, Arnaldo, additional, Hoetker, Glenn, additional, and Jacobides, Michael G, additional
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- 2017
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37. Managerial Cognitive Capabilities, Mental Representations of Routines and Market Entry by Analogy
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Engler, Daniel, primary, Yang, Hisan, additional, and Kim, Ji-hyun, additional
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- 2017
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- View/download PDF
38. Atrial fibrillation patterns are associated with arrhythmia progression and clinical outcomes.
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Schnabel, Renate B., Pecen, Ladislav, Engler, Daniel, Lucerna, Markus, Sellal, Jean Marc, Ojeda, Francisco M., De Caterina, Raffaele, Kirchhof, Paulus, and B Schnabel, Renate
- Subjects
ATRIAL fibrillation ,ARRHYTHMIA ,HEART failure ,ELECTRIC countershock ,HYPERTHYROIDISM ,DIABETES ,HEALTH outcome assessment - Abstract
Objectives: Determinants of atrial fibrillation (AF) patterns and of progression of earlier forms to permanent AF, and their relationship with outcome are still poorly understood.Methods: We examined AF patterns (paroxysmal, persistent and permanent), rate and predictors of AF progression, and outcomes in the PREFER (PREvention oF thromboembolic events-European Registry) in AF. The primary analysis was performed in the PREFER in AF prolongation dataset (n=3223 patients with AF with a complete 1-year follow-up, mean age 72±9 years, 40% women). Sensitivity analyses were performed using the PREFER in the AF study (n=6390 patients).Results: AF progressed to more persistent types in 506 patients (17%). Permanent AF was associated with development of heart failure at 1 year (OR 1.80, 95% CI 1.06 to 3.07, p=0.03) compared with paroxysmal AF, which was confirmed in the entire cohort. In multivariable-adjusted models, sinus rhythm at baseline, AF duration, cardioversion, hyperthyroidism, valvular heart disease, diabetes mellitus and heart failure were predictors of AF progression (area under the receiver operating characteristic curve 0.60, 95% CI 0.57 to 0.63). Results were similar when we restricted analyses to patients with AF duration <1 year. AF progression showed an association with coronary events over 1 year (OR 2.27, 95% CI 1.22 to 4.19, p=0.0074).Conclusions: Permanent AF at baseline was associated with incident heart failure. A substantial proportion of well-managed patients with AF showed AF progression over 1 year. AF progression itself was not strongly related to outcome and may indicate the need to refine the current classification of AF types to enhance clinical utility. [ABSTRACT FROM AUTHOR]- Published
- 2018
- Full Text
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39. Holzkristall
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Engler, Daniel
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- 2009
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40. Einfach effizient
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Engler, Daniel
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- 2007
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41. Gefaltete Glasfassade
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Engler, Daniel
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- 2006
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42. Markthalle und Perrondach
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Engler, Daniel
- Published
- 2006
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43. Plattform und Treppe
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Engler, Daniel
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- 2006
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- View/download PDF
44. Leise abrollen
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Engler, Daniel
- Published
- 2006
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45. Eine Strasse wird gezügelt
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Engler, Daniel
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- 2006
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46. Vom Velodrom zum Technotempel
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Engler, Daniel
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- 2005
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47. Kanadischer Holzbau
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Engler, Daniel
- Published
- 2005
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48. Zürcher Hallenstadion: Baugeschichte
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Engler, Daniel
- Published
- 2005
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49. Rolltreppe zum See
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Engler, Daniel
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- 2005
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50. Behutsame Ergänzung
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Engler, Daniel
- Published
- 2005
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