22 results on '"Eroglu, T"'
Search Results
2. A comparison of pre-emptive analgesic efficacy of diflunisal and lornoxicam for postoperative pain management: a prospective, randomized, single-blind, crossover study
- Author
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Pektas, Z.O., Sener, M., Bayram, B., Eroglu, T., Bozdogan, N., Donmez, A., Arslan, G., and Uckan, S.
- Published
- 2007
- Full Text
- View/download PDF
3. Condition evaluation and strengthening techniques for Kayakapi ruins in Turkey
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Turer, A, primary and Eroglu, T, additional
- Published
- 2004
- Full Text
- View/download PDF
4. Effect of Different Modelling Assumptions on the Seismic Response of RC Structures
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Sousa, Romain, Eroglu, T, Kazantzidou, D., Kohrangi, M., Sousa, Luís, Nascimbene, Roberto, and Pinho, Rui
- Subjects
Irregular RC structures ,Nonlinear static analysis ,Modelling issues - Abstract
The introduction of new regulations for seismic assessment of structures established stricter performance requirements for existing buildings. In order to account for the poor seismic behaviour of such buildings, recent seismic codes, namely Eurocode 8 (EC8), introduce a number of prescriptions regarding issues such as analysis type, load distribution, accidental eccentricity, etc. At the same time, these codes give room for engineering judgment to be used with reference to the definition of structural and non-structural elements such as slabs or infill walls, and obviously leave the modelling assumptions, such as Finite Elements typology, meshing, mass modelling, etc. to the analyst decision. As such, four existing RC buildings, representative of traditional Mediterranean construction, considering different modelling assumptions, were subjected to an extensive number of nonlinear static analyses. The interpretation of possible deviations in the results will hopefully provide indications on the relative importance of each modelling parameter or decision. N/A
- Published
- 2012
5. Using Nonlinear Static Procedures for the Seismic Assessment of Irregular RC Buildings
- Author
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Sousa, Romain, Eroglu, T, Kazantzidou, D., Kohrangi, M., Sousa, L., Nascimbene, Roberto, and Pinho, R.
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Nonlinear Static Procedures ,Irregular 3D buildings - Abstract
The application of Nonlinear Static Procedures (NSPs) to assess the seismic vulnerability of existing structures has become widely accepted and extensively used in the literature as well as in engineering practice. Nevertheless, their success in predicting the response of irregular buildings is not yet fully verified. The main goal of the present study is to evaluate the capability and accuracy of some of the existing nonlinear static procedures (N2 and ACSM, in this case) to estimate the seismic performance of irregular structures. In order to accomplish this objective, four existing buildings, irregular in plan and elevation, were subjected to an extensive number of nonlinear static and dynamic analyses. The comparisons, focused on both global and local response parameters provide first indications on the reliability of static procedures to estimate the actual response of irregular RC buildings. N/A
- Published
- 2012
6. Genetic chracterisation of various cat breeds by using microsatellites in Turkey
- Author
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Kurar, E., Altunok, V., Ozsensoy, Y., Nizamlioglu, M., Yüksek, Nazmi, and Eroglu, T.
- Published
- 2008
7. The effects of N-acetylcysteine on pulmonary functions in patients undergoing on-pump coronary artery surgery: a double blind placebo controlled study.
- Author
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ERDIL, N., EROGLU, T., AKCA, B., DISLI, O. M., YETKIN, O., COLAK, M. C., ERDIL, F., and BATTALOGLU, B.
- Abstract
OBJECTIVE: To investigate the effects of N-acetylcysteine (NAC) on pulmonary function tests and arterial blood gases in patients undergoing on-pump coronary artery surgery. PATIENTS AND METHODS: The effect of NAC was assessed within the scope of a prospective, single center, double-blind, placebo-controlled, parallel group study. Eighty-two patients undergoing coronary artery bypass grafting were randomized into two groups to receive either placebo (group 1, n = 40) or NAC (group 2, n=42). Both the NAC group and the placebo-receiving control group also included a COPD subgroup consist ing of pat ients wi th an FEV
1 /FVC ratio of < 0.7 and an FEV1 value of 50- 80%. Pulmonary function tests were performed preoperatively and on postoperative day 60. RESULTS: Both groups were similar with respect to age, gender, preoperative risk factors, ejection fraction (EF), mean cross-clamp time, ventilation time, intensive care unit (ICU) stay, atrial fibrillation (AF) and hospital stay (p > 0.05). Postoperative FVC and FEV1 values in group 1 and the postoperative FEV1 , FEV1 /FVC and FEF 25-75 values in group 2 were lower in comparison to their preoperative values. However, in both group 1 and 2, the decreases observed in these parameters were not statistically significant (p > 0.05). In the COPD subgroup of group 1, a postoperative decrease was observed in the FEV1 and FEF25-75 values, with the FEV1 decreasing by 4.55%, and the FEF25-75 decreasing by 4.2% (p < 0.05). In the COPD subgroup of group 2, no significant decrease was observed in the pulmonary function test values (p > 0.05). CONCLUSIONS: This study demonstrated that NAC administration in COPD patients undergoing on-pump coronary artery surgery resulted in the preservation of pulmonary functions. [ABSTRACT FROM AUTHOR]- Published
- 2016
8. On-pump Coronary Artery Bypass Surgery in High-risk Patients Aged over 65 Years (EuroSCORE 6 or More): Impact on Early Outcomes
- Author
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Erdil, N, primary, Nisanoglu, V, additional, Kaynak, M, additional, Fansa, I, additional, Eroglu, T, additional, Cihan, HB, additional, and Battaloglu, B, additional
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- 2009
- Full Text
- View/download PDF
9. A novel sorbent tube for ambient hydrogen sulfide determination
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Volkan, M., Eroglu, T., Eroglu, A. E., Ataman, O. Y., and Mark, H. B.
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- 1998
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10. Systems Biology Approach Uncovers Candidates for Liver-Heart Interorgan Crosstalk in HFpEF.
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Strocchi S, Liu L, Wang R, Häseli SP, Capone F, Bode D, Nambiar N, Eroglu T, Santiago Padilla L, Farrelly C, Vacca A, Mascagni M, Oeing CU, Kintscher U, Jung S, Diezel SA, Liévano Contreras SV, Zhou M, Seldin M, and Schiattarella GG
- Published
- 2024
- Full Text
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11. Quantitative CT Morphometrics: A Novel Approach for Predicting the Bladder Cancer Grade.
- Author
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Eroglu T, Köseoğlu H, Yücetaş U, Ari E, and Kadihasanoglu M
- Abstract
Background and objective Bladder cancer (BC) is a common urothelial neoplasm, with non-muscle invasive forms comprising about 75% of cases and generally having better outcomes than muscle-invasive types. Accurate preoperative grading and staging of BC are essential for appropriate treatment planning. This study investigates the efficacy of computerized tomography (CT) in correlating the morphological features of tumors to predict the histopathological grades of BC. Materials and methods This retrospective cohort involved 100 patients diagnosed with non-muscle invasive BC, who underwent transurethral resection of bladder tumor (TUR-BT) between January 2010 and August 2021. CT imaging, utilizing a 128-slice CT scanner, was employed to measure the tumor height (H) and contact length (CL). The study considered morphometric parameters across axial, coronal, and sagittal planes. Statistical analyses were conducted, comparing radiological findings with histopathological evaluations. Tumor grading was determined according to the 2004/2016 WHO classification. Results Among the 100 patients with primary bladder tumors, 15 were female and 85 were male, with a mean age of 65.28 ± 7.11 years. Furthermore, 58 had high-grade bladder tumors, while 42 had low-grade bladder tumors. Across all planes, high-grade tumors exhibited higher values for the tumor H, CL, and the tumor height-to-contact length (H/CL) ratio compared to low-grade tumors (p<0.05). Notably, the specificity, sensitivity, and diagnostic accuracy of the tumor CL were higher than those of the tumor H and the tumor H/CL ratio. A tumor CL exceeding 19.1mm measured in the axial plane demonstrated 83% sensitivity and specificity for high-grade tumors. Conclusion The measured CL of the tumor in the axial plane on computerized tomography urography has high sensitivity and specificity in detecting high-grade tumors., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Health Sciences University, Istanbul Health Practice and Research Center Clinical Research and Ethics Committee issued approval Decision No: 2901, dated 13.08.2021. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Eroglu et al.)
- Published
- 2024
- Full Text
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12. Impact of Single versus Double Clamp Technique on Blood Lactate Levels and Postoperative Complications in Coronary Artery Bypass Surgery.
- Author
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Özmen R, Bozguney M, Tekin Aİ, Eroglu T, and Tuncay A
- Subjects
- Humans, Lactates, Postoperative Complications etiology, Retrospective Studies, Cardiopulmonary Bypass adverse effects, Cardiopulmonary Bypass methods, Coronary Artery Bypass adverse effects, Coronary Artery Bypass methods
- Abstract
Introduction: Cardiopulmonary bypass (CPB) is associated with hyperlactatemia, which leads to adverse clinical outcomes. No study has examined the effect of different clamping techniques on postoperative hyperlactatemia (PHL). Thus, we aimed to evaluate the impact of two different techniques on PHL and the clinical outcomes in patients undergoing isolated coronary artery bypass surgery., Methods: This retrospective study included 100 patients who underwent isolated CPB either with single clamp technique (SCT, n=47) or double clamp technique (DCT, n=53). Demographic and preoperative laboratory data, as well as operative features and arterial blood lactate levels at the onset and at the end of CPB, were collected from patient charts., Results: Blood lactate levels collected at the end of CPB did not differ significantly between groups whereas intraoperative lactate increased significantly in both groups (P<0.005). PHL developed in 16 patients (32%). There was no meaningful difference in SCT and DCT in this regard. Left internal mammary artery was used more frequently in the DCT group than in the SCT group. While the cross-clamp time was significantly longer in the SCT group, there was no difference regarding CPB time. Among postoperative complications, only the incidence of stroke was significantly higher in the DCT group than in the SCT group (10.6% vs. 0%, P=0.020). CPB time, cross-clamp time and numbers of proximal saphenous graft and distal anastomosis showed a significant positive correlation with the postoperative lactate level. In the regression analysis, CPB time emerged as the only independent predictor of PHL (OR 1.04, CI 95% 1.01-1.07, P=0.011)., Conclusion: There was no difference in postoperative blood lactate levels between SCT and DCT groups.
- Published
- 2022
- Full Text
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13. Impaired semen parameters in patients with confirmed SARS-CoV-2 infection: A prospective cohort study.
- Author
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Pazir Y, Eroglu T, Kose A, Bulut TB, Genc C, and Kadihasanoglu M
- Subjects
- Adult, Cohort Studies, Humans, Male, Prospective Studies, RNA, Viral, Semen, Semen Analysis, Sperm Count, Sperm Motility, COVID-19, SARS-CoV-2
- Abstract
In this prospective study, we investigated the impact of SARS-CoV-2 infection on semen parameters in a cohort of men who had recently recovered from COVID-19. A total of 24 men who had recently recovered from mild COVID-19 were included in the study. Their semen parameters were normal before COVID-19 according to the World Health Organization 2010 reference values. Semen samples were collected from these participants in the recovery phases of COVID-19. To determine the effect of SARS-CoV-2 infection on semen parameters, the patients' pre-COVID-19 and post-COVID-19 semen analyses were compared. The mean age of the participants was 34.7 ± 6.4 years. The median interval between the positive nasopharyngeal swab test and obtaining semen samples was 111.5 (158) days. There was no significant difference in semen parameters before and after COVID-19 in terms of semen volume (p = .56), sperm concentration (p = .06), and progressive motility (p = .14). Total motility (p = .01) and total motile sperm count (p = .02) decreased significantly after SARS-CoV-2 infection compared to the pre-infection values. This study demonstrated that sperm motility and total motile sperm count were the semen parameters which showed a significant reduction in cases with a history of mild COVID-19., (© 2021 Wiley-VCH GmbH.)
- Published
- 2021
- Full Text
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14. Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes.
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van Dongen LH, de Goede P, Moeller S, Eroglu TE, Folke F, Gislason G, Blom MT, Elders PJM, Torp-Pedersen C, and Tan HL
- Abstract
Objective: Out-of-hospital cardiac arrest (OHCA) occurrence has been shown to exhibit a circadian rhythm, following the circadian rhythm of acute myocardial infarction (AMI) occurrence. Diabetes mellitus (DM) is associated with changes in circadian rhythm. We aimed to compare the temporal variation of OHCA occurrence over the day and week between OHCA patients with DM and those without., Methods: In two population-based OHCA registries (Amsterdam Resuscitation Studies [ARREST] 2010-2016, n = 4163, and Danish Cardiac Arrest Registry [DANCAR], 2010-2014, n = 12,734), adults (≥18y) with presumed cardiac cause of OHCA and available medical history were included. Single and double cosinor analysis was performed to model circadian variation of OHCA occurrence. Stratified analysis of circadian variation was performed in patients with AMI as immediate cause of OHCA., Results: DM patients (22.8% in ARREST, 24.2% in DANCAR) were older and more frequently had cardiovascular risk factors or previous cardiovascular disease. Both cohorts showed 24 h-rhythmicity, with significant amplitudes in single and double cosinor functions ( P -range < 0.001). In both registries, a morning peak (10:00-11:00) and an evening peak (20:00-21:00) was observed in both DM and non-DM patients. No septadian variation was observed in either DM or non-DM patients ( P -range 0.13-84)., Conclusions: In these two population-based OHCA registries, we observed a similar circadian rhythm of OHCA occurrence in DM and non-DM patients., (© 2021 The Authors.)
- Published
- 2021
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15. Evaluation of the role of Nrf2/Keap1 pathway-associated novel mutations and gene expression on antioxidant status in patients with deep vein thrombosis.
- Author
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Akin-Bali DF, Eroglu T, Ilk S, Egin Y, and Kankilic T
- Abstract
Deep vein thrombosis (DVT) is a type of venous thromboembolism and a clinically complex vascular disease. Oxidative stress serves a key role in the pathogenesis of numerous cardiovascular diseases, particularly in endothelial dysfunction-associated syndromes. Nuclear factor erythroid-2-like 2(Nrf2) transcription factor is the primary regulator of antioxidant responses. The levels of reactive oxygen species (ROS) are regulated by Nrf2 and its suppressor protein Kelch-like ECH-associated protein 1 (Keap1). However, to the best of our knowledge, genetic abnormalites in the Nrf2/Keap1 pathway in DVT syndrome have not been thoroughly investigated. The aim of the present study was to investigate the association between the Nrf2/Keap1 pathway and antioxidant responses in DVT. Mutations and expression levels of genes involved in the Nrf2/Keap1 pathway were measured in 27 patients with DVT via DNA sequencing analysis and reverse transcription-quantitative PCR, respectively. The Polymorphism Phenotyping v2 program was used to identify the pathogenic mutations. Total antioxidant activity levels were determined by measuring the effect of serum samples from 27 patients with DVT on oxidation of the 2,2'-azino-bis (3-ethylbenz-thiazoline-6-sulfonic acid) system. A total of 23 mutations, including seven novel mutations, were detected in the Nrf2/Keap1 pathway in 24 (89%) of the 27 patients with DVT. Keap1 mRNA expression levels were significantly higher compared with Nrf2 expression levels in patients with DVT (P=0.02). Analysis of molecular characteristics and gene expression levels demonstrated that Nrf2/Keap1-associated mutations and total antioxidant levels can be used as precursor markers in the diagnosis of DVT., (Copyright: © Akin-Bali et al.)
- Published
- 2020
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16. Evaluation of ABO blood groups and blood-based biomarkers as a predictor of growth kinetics of renal angiomyolipoma.
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Arslan B, Gürkan O, Çetin B, Arslan ÖA, Göv T, Yazıcı G, Eroglu T, Avcı MA, and Ozdemir E
- Subjects
- Adult, Aged, Angiomyolipoma physiopathology, Biomarkers blood, Female, Glomerular Filtration Rate, Humans, Kidney pathology, Kidney physiopathology, Kidney Neoplasms physiopathology, Male, Middle Aged, Retrospective Studies, ABO Blood-Group System, Alanine Transaminase blood, Angiomyolipoma blood, Angiomyolipoma pathology, Aspartate Aminotransferases blood, Kidney Neoplasms blood, Kidney Neoplasms pathology
- Abstract
Purpose: The aim of our study was to investigate the impact of the ABO blood groups and blood-based biomarkers on the growth kinetics of renal angiomyolipoma (AML)., Methods: A total of 124 patients with AML who were followed-up between 2010 and 2018 were retrospectively reviewed. The patients' characteristics were recorded, including age, body mass index (BMI), blood pressure, smoking history, and ABO blood group. Baseline laboratory test results, including serum creatinine, AST, ALT, platelet, neutrophil and lymphocyte count, were used to calculate the estimated glomerular filtration rate (eGFR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and De Ritis ratio. The Cox regression analysis was used to evaluate the relationship between variables and tumor growth., Results: The study population comprised 71 women and 44 men with a median age of 47.3 (28-65) years. Among patients classified according to the blood groups, no significant differences were observed regarding age, BMI, smoking history, co-morbidities, NLR, PLR, De Ritis ratio, eGFR, or tumor size and localisation. The mean growth rate from baseline to the last scan was 0.36 ± 0.27 cm, 0.21 ± 0.21 cm, 0.14 ± 0.11 cm, and 0.19 ± 0.17 cm for blood type O, A, B, and AB, respectively. In multivariate analysis, eGFR < 60 (p = 0.044), central tumor localisation (p = 0.030), presence of blood group-0 (p = 0.038), and De Ritis ratio ≥ 1.24 (p = 0.047) were statistically associated with tumor growth., Conclusion: Our study demonstrates that both the ABO blood groups and the De Ritis ratio might represent independent predictors of tumor growth rate in patients with renal AML.
- Published
- 2018
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17. A Study on the Effects of the Use of Propofol in Experimental Model Inferior Epigastric Island Flap on Ischemia-Reperfusion Injury.
- Author
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Eroglu T, Bozkurt M, Kapi E, Selcuk CT, Kuvat SV, Tufek A, Isik FB, Bozarslan BH, Firat U, and Satici O
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- Animals, Malondialdehyde metabolism, Rats, Rats, Sprague-Dawley, Superoxide Dismutase metabolism, Antioxidants therapeutic use, Epigastric Arteries physiology, Propofol therapeutic use, Reperfusion Injury drug therapy, Reperfusion Injury prevention & control, Surgical Flaps blood supply, Surgical Flaps surgery
- Abstract
Problems concerning vascular blood flow are the most frequently encountered ones after flap applications. The flap tissue starts to develop ischemia in patients with a vascular blood flow insufficiency. And reperfusion starts in those patients in whom the ischemia is temporary, triggering an ischemia-reperfusion injury depending on the duration of the ischemia. The aim of this study was to evaluate the effect of propofol, which is an anesthetic agent known to have an antioxidant effect and a free radical scavenging feature on the ischemia-reperfusion injury created on an experimental epigastric island flap.Thirty Sprague-Dawley rats were used in the study. The rats were divided into 3 groups of 10 rats each. Inferior epigastric artery-based abdominal flaps were prepared in all the groups. In group 1 (sham), the flap was elevated but no ischemia was applied. In groups 2 (control) and 3 (propofol), the flap was exposed to ischemia for 2 hours after it was elevated. All the rats were sacrificed and biochemical and histopathological assessments were made on the tissue samples taken on the 14th day. As a result of a comparison between the groups, the flap viability rates and the superoxide dismutase, total antioxidant capacity, and catalase values were found to be significantly higher (P < 0.001) in the propofol group while the malondialdehyde and total oxidative stress values were lower (P < 0.001). Based on the data obtained from the present study, the use of propofol was observed to have a protective effect against ischemia-reperfusion injuries in flap surgeries.
- Published
- 2017
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18. Early outcomes of radial artery use in all-arterial grafting of the coronary arteries in patients 65 years and older.
- Author
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Erdil N, Nisanoglu V, Eroglu T, Fansa I, Cihan HB, and Battaloglu B
- Subjects
- Age Factors, Aged, Chi-Square Distribution, Coronary Angiography, Coronary Artery Bypass adverse effects, Coronary Artery Bypass mortality, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease mortality, Female, Humans, Length of Stay, Linear Models, Male, Radial Artery diagnostic imaging, Retrospective Studies, Risk Assessment, Risk Factors, Saphenous Vein diagnostic imaging, Surgical Wound Infection etiology, Time Factors, Tissue and Organ Harvesting adverse effects, Treatment Outcome, Turkey, Vascular Patency, Coronary Artery Bypass methods, Coronary Artery Disease surgery, Radial Artery transplantation, Saphenous Vein transplantation
- Abstract
We retrospectively evaluated early clinical results of coronary revascularization using none but arterial grafts in patients aged 65 years and older. The cases of 449 consecutive patients who had undergone isolated myocardial revascularization were divided into 2 groups: the arterial conduit group (n=107) received a left internal mammary artery (LIMA) graft and 1 or both radial arteries (RAs), while the mixed-conduit group (n=342) received a LIMA graft and 1 or more saphenous vein grafts (SVGs), with or without an RA. There was no significant difference between the groups' rates of mortality. The arterial conduit group had a significantly shorter overall postoperative hospital stay than did the mixed-conduit group (mean, 6.6 +/- 0.9 vs 7.2 +/- 5 days; P=0.04). Linear regression analysis revealed that the presence of hypertension (beta=0.13; 95% confidence interval [CI], 0.054-0.759; P=0.02) and high EuroSCORE (beta=0.24; 95% CI, 0.053-0.283; P=0.004) were the major predicting factors for long hospital stay. Graft-harvest-site infection was statistically more frequent in the mixed-conduit group than in the arterial conduit group (6.4% vs 0, respectively; P=0.007). Angiography was performed postoperatively (mean, 24.9 +/- 16.3 mo; range, 11-65 mo) in 21 patients. In these patients, all LIMA grafts were patent, as were 86.9% of the SVGs and 90.9% of the RA grafts. Myocardial revascularization using all arterial grafts (at least 50% RAs) in patients aged 65 years and older is safe and reliable, produces short-term results equal to those of saphenous vein grafting, and can reduce graft-harvest-site infections.
- Published
- 2010
19. Use of a resorbable nut system for simultaneous implant insertion and maxillary sinus floor elevation.
- Author
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Uckan S, Eroglu T, Dayangac E, and Araz K
- Subjects
- Absorbable Implants, Dental Implantation, Endosseous methods, Humans, Dental Implantation, Endosseous instrumentation, Dental Prosthesis Retention instrumentation, Maxillary Sinus surgery
- Published
- 2007
- Full Text
- View/download PDF
20. Effects of pretreatment with different topical vasodilators on blood flow in the internal mammary artery: a prospective randomized study.
- Author
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Battaloglu B, Nisanoglu V, Erdil N, Ozgur B, Eroglu T, Aydin N, Kaynak M, and Secici S
- Subjects
- Adenosine administration & dosage, Administration, Topical, Adult, Aged, Coronary Angiography, Coronary Artery Bypass methods, Coronary Stenosis diagnostic imaging, Coronary Stenosis surgery, Diltiazem administration & dosage, Female, Graft Rejection, Graft Survival, Humans, Male, Middle Aged, Nitroglycerin administration & dosage, Papaverine administration & dosage, Probability, Prospective Studies, Reference Values, Severity of Illness Index, Treatment Outcome, Vascular Patency drug effects, Internal Mammary-Coronary Artery Anastomosis methods, Mammary Arteries drug effects, Tissue and Organ Harvesting methods, Vasodilator Agents administration & dosage
- Abstract
Background: This study was conducted to investigate how brief pretreatments with 4 different vasodilators applied topically at normal body temperature affect blood flow in the internal mammary artery., Methods: One hundred patients who had an internal mammary artery mobilized as a pedicle for coronary artery bypass grafting were randomly assigned to one of 5 groups of equal size (20 subjects in each). Each group of pedicles was treated with a different topical solution: normal saline (control), nitroglycerin, diltiazem, papaverine, or adenosine. Internal mammary artery flow and hemodynamic measurements were recorded immediately after harvesting and after 5 minutes of immersion in a tube filled with test solution (50 mL at 37 degrees C). Results for each study variable were compared within and between groups, and posttreatment-to-pretreatment ratios were also calculated and compared., Results: All 4 vasodilator groups showed a significant increase in internal mammary artery flow rate from pretreatment to posttreatment, whereas the saline group did not. There were no significant differences among the 5 groups' pretreatment flow rates (P = .526) or posttreatment flow rates (P = .194). The mean ratio values (posttreatment-to-pretreatment) for flow rate were 1.08 +/- 0.17 in the saline group, 1.74 +/- 0.17 with nitroglycerin, 1.77 +/- 0.49 with diltiazem, 1.82 +/- 0.59 with papaverine, and 1.57 +/- 0.54 with adenosine. Post hoc analysis revealed that the mean ratio values for flow rate in the 4 vasodilator groups were significantly higher than the corresponding ratio in the saline group., Conclusions: Brief treatment of the internal mammary artery with topical vasodilators at normal body temperature significantly increases blood flow in this vessel. The data from this study are particularly valuable in relation to off-pump surgery, in which this vessel is usually anastomosed soon after it is harvested.
- Published
- 2007
- Full Text
- View/download PDF
21. Topical vasodilators for preventing radial artery spasm during harvesting for coronary revascularization: comparison of 4 agents.
- Author
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Nisanoglu V, Battaloglu B, Ozgur B, Eroglu T, and Erdil N
- Subjects
- Administration, Topical, Adult, Aged, Blood Flow Velocity drug effects, Coronary Artery Bypass methods, Female, Humans, Male, Middle Aged, Organ Preservation Solutions administration & dosage, Radial Artery transplantation, Coronary Artery Bypass instrumentation, Coronary Vasospasm prevention & control, Organ Preservation methods, Radial Artery drug effects, Radial Artery physiology, Tissue and Organ Harvesting methods, Vasodilator Agents administration & dosage
- Abstract
Background: There is still controversy about which vasodilator solution is best for storing radial artery (RA) conduits prior to coronary artery bypass grafting. The aim of this pilot study was to investigate how 4 different topical vasodilators applied during RA harvesting affect blood flow with the vessel in situ., Materials and Methods: The subjects were 85 patients who underwent RA harvesting in preparation for coronary artery bypass grafting. Each case was assigned to 1 of 5 groups (17 RAs each) that were treated with different solutions: normal saline (control), nitroglycerin, diltiazem, papaverine, and adenosine. Standard clinical concentrations were used. The RA was partially harvested (pedicle attached proximally) and flow rates and hemodynamic parameters (mean arterial pressure, heart rate, central venous pressure) were recorded at 2 time points: (1) pretreatment and (2) after 5 minutes of immersion in 60 mL of treatment solution. Results were compared within and between groups, and post-treatment-to-pretreatment ratios were calculated for each variable., Results: There were no significant differences among the groups' mean pretreatment flow rates (P = .979) or mean posttreatment flow rates (P = .069). All except the diltiazem group showed a significant rise in mean flow rate from pretreatment to posttreatment. The mean posttreatment-to-pretreatment ratios for RA flow rate were 1.28 +/- 0.39 in the saline group, 1.85 +/- 0.72 in the nitroglycerin group, 1.31 +/- 0.48 in the diltiazem group, 1.37 +/- 0.64 in the papaverine group, and 1.23 +/- 0.42 in the adenosine group. Only the mean flow ratio in the nitroglycerin group was significantly higher than that in the saline group (P = .003). The mean flow ratios in the other vasodilator groups were not statistically different from the flow ratio in the saline group., Conclusions: These preliminary results indicate that topical application of nitroglycerin solution effectively prevents perioperative spasm of the RA in patients undergoing coronary artery bypass surgery. The authors recommend this solution for preparation and storage of RA grafts. Randomized controlled trials with power analysis will give more definitive information.
- Published
- 2006
- Full Text
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22. The use of tumor markers as predictors of prognosis in gastric cancer.
- Author
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Mihmanli M, Dilege E, Demir U, Coskun H, Eroglu T, and Uysalol MD
- Subjects
- Adult, Aged, Female, Gastrectomy, Humans, Lymph Nodes pathology, Lymphatic Metastasis pathology, Male, Middle Aged, Neoplasm Invasiveness pathology, Neoplasm Staging, Predictive Value of Tests, Prognosis, Reference Values, Statistics as Topic, Stomach pathology, Stomach Neoplasms mortality, Stomach Neoplasms pathology, Stomach Neoplasms surgery, Survival Analysis, Biomarkers, Tumor blood, CA-19-9 Antigen blood, Carcinoembryonic Antigen blood, Postoperative Complications mortality, Stomach Neoplasms diagnosis
- Abstract
Background/aims: The aim of this study was to evaluate the prognostic significance of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9) levels in patients with gastric cancer., Methodology: During the period January 2000 and January 2003, 36 patients operated for primary gastric cancer, at Sisli Etfal Training and Research Hospital, Department of General Surgery, were analyzed. Serum CEA and CA19-9 levels were determined preoperatively and the correlation between the elevated levels of tumor markers and several clinicopathological features, and survival were evaluated., Results: Elevated serum CEA and CA19-9 levels were determined in 10 of 35 patients (28.6%), and 9 of 31 patients (29%), respectively, and both markers were elevated in 3 of 31 patients (9.6%). Elevated levels of CEA correlated with depth of invasion (p=0.018) and pathological stage (p=0.029); elevated levels of CA19-9 correlated with lymph node metastasis (p=0.026); and elevated levels of both markers correlated well with lymph node metastasis (p=0.031). The survival of patients with normal CEA levels was significantly better than those with elevated levels (p=0.0072)., Conclusions: Preoperative serum CEA and CA19-9 levels may add useful information in patients with gastric carcinoma, and CEA level is a predictor of prognosis.
- Published
- 2004
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