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Your search keyword '"European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)"' showing total 11 results
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11 results on '"European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)"'

1. Advances on Microsupercapacitors: Real Fast Miniaturized Devices toward Technological Dreams for Powering Embedded Electronics?

Author

Pascal Roussel, Christophe Lethien, Khac Huy Dinh, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Circuits Systèmes Applications des Micro-ondes - IEMN (CSAM - IEMN ), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Réseau sur le stockage électrochimique de l'énergie (RS2E), Aix Marseille Université (AMU)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Collège de France (CdF (institution))-Université de Picardie Jules Verne (UPJV)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Pau et des Pays de l'Adour (UPPA)-Institut de Chimie du CNRS (INC)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA)-Université Grenoble Alpes (UGA)-Nantes Université (Nantes Univ)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Université de Montpellier (UM), This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 847568. The authors thank the French National Research Agency (STORE-EX Labex Project ANR-10-LABX-76-01). The French RENATECH network and the University of Lille are greatly acknowledged for supporting the Center of MicroNanoFabrication (CMNF) facility from IEMN., Renatech Network, ANR-10-LABX-0076,STORE-EX,Laboratory of excellency for electrochemical energy storage(2010), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
General Chemical Engineering, General Chemistry, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics
Abstract

International audience; Electrochemical lithium (de)intercalation in an atomic layer deposited (ALD) TiO2 anatase thin film deposited on a planar Si /Al2O3/Pt substrate is investigated by Raman spectroscopy. An initial discharge capacity of 63 µAh cm−2 µm−1 (0.5 Li+ mole−1) is reached at C/10 rate, which increases up to 77 µAh cm−2 µm−1 upon further cycles. An excellent capacity retention is achieved over at least 100 cycles, showing the good adherence of the ALD thin film. Raman spectra of LixTiO2 (0 ≤ x ≤ 0.5) thin film electrodes point to the nucleation of the orthorhombic lithiated titanate (LT) Li0.5TiO2 phase from x = 0.1. This LT phase coexists with tetragonal TiO2 in the 0.1 ≤ x ≤ 0.4 composition domain to be pure for x = 0.5. A fully reversible transformation from orthorhombic LT to tetragonal TiO2 is observed upon the charge. The high quality of the Raman spectra allows identifying for the first time 12 modes in the 100–800 cm−1 region for the electrochemically formed LT phase. Furthermore, an appropriate Raman spectra analysis allows a reliable and quantitative determination of the thin film composition during discharge and charge. These results illustrate Raman spectroscopy is a powerful probe to scrutinize the Li insertion/extraction mechanism in TiO2 thin films.

Published
2023
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2. Influence of the Size and Charge of Carbon Quantum Dots on Their Corneal Penetration and Permeation Enhancing Properties

Author

Inès De Hoon, Alexandre Barras, Tomasz Swebocki, Bernd Vanmeerhaeghe, Bram Bogaert, Cristina Muntean, Amar Abderrahmani, Rabah Boukherroub, Stefaan De Smedt, Félix Sauvage, Sabine Szunerits, Universiteit Gent = Ghent University (UGENT), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Financial support from the 'Programme Investissement d’Avenir' (I-SITE ULNE / ANR-16-IDEX-0004 ULNE) managed by the 'Agence Nationale de la Recherche' is acknowledged. In addition, this project has received funding from the European Union’s Horizon 2020 research and innovation program under the 'Marie Sklodowska-Curie grant' (agreement No 847568). Financial support from theCentre National de la Recherche Scientifique (CNRS) and the University of Lille is acknowledged in addition. F. Sauvage is a post-doctoral fellow of the Research Foundation-Flanders (grant number 12X3222N, FWO, Belgium). This work was partly supported by the French Renatech network. The authors would like to thank Maya Marinova for her help in carrying out the work on the electron microscopy facility of the Advanced Characterization Platform of the Chevreul Institute. The Chevreul Institute is thanked for help in the development of this work through the ARCHI-CM project supported by the 'Ministère de l’Enseignement Supérieur de la Recherche et de l’Innovation,' the region 'Hauts-de-France,' the ERDF program of the European Union, and the 'Métropole Européenne de Lille.', Renatech Network, ANR-16-IDEX-0004,ULNE,ULNE(2016), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
[SPI]Engineering Sciences [physics], endothelium, cornea, General Materials Science, fluorescence spectroscopy, epithelium, carbon quantum dots
Abstract

International audience; Reaching the corneal endothelium through the topical administration of therapeutic drugs remains a challenge in ophthalmology. Besides, endothelial cells are not able to regenerate, and diseases at this site can lead to corneal blindness. Targeting the corneal endothelium implies efficient penetration through the three corneal layers, which still remains difficult for small molecules. Carbon quantum dots (CQDs) have demonstrated great potential for ocular nanomedicine. This study focuses on the corneal penetration abilities of differently charged CQDs and their use as permeation enhancers for drugs. Excised whole bovine eyes were used as an ex vivo model to investigate corneal penetration of CQDs derived from glucosamine using β-alanine, ethylenediamine, or spermidine as a passivation agent. It was found that negatively charged CQDs have limited corneal penetration ability, while positively charged CQDs derived from glucosamine hydrochloride and spermidine (CQD-S) penetrate the entire corneal epithelium all the way down to the endothelium. CQD-S were shown to enhance the penetration of FITC-dextran 150 kDa, suggesting that they could be used as efficient penetration enhancers for therapeutic delivery to the corneal endothelium.

Published
2023
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3. In Vitro and Ex Vivo Models for Assessing Drug Permeation across the Cornea

Author

de Hoon, Inès, Boukherroub, Rabah, de Smedt, Stefaan, Szunerits, Sabine, Sauvage, Félix, Universiteit Gent = Ghent University (UGENT), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Financial support from the 'Programme Investissement d’Avenir' (I-SITE ULNE/ANR-16-IDEX-0004 ULNE) managed by the 'Agence Nationale de la Recherche' is acknowledged. In addition, this project has received support from the European Union’s Horizon 2020 research and innovation program under the 'Marie Sklodowska-Curie grant' (agreement no. 847568). Financial support from the Centre National de la Recherche Scientifique (CNRS) and the University of Lille are also acknowledged. This work was partly supported by the French Renatech network., Renatech Network, ANR-16-IDEX-0004,ULNE,ULNE(2016), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
[PHYS]Physics [physics], corneal penetration, [SPI]Engineering Sciences [physics], cornea, in vitro model, drug delivery, drug diffusion, ex vivo model
Abstract

International audience; Drug permeation across the cornea remains a major challenge due to its unique and complex anatomy and physiology. Static barriers such as the different layers of the cornea, as well as dynamic aspects such as the constant renewal of the tear film and the presence of the mucin layer together with efflux pumps, all present unique challenges for effective ophthalmic drug delivery. To overcome some of the current ophthalmic drug limitations, the identification and testing of novel drug formulations such as liposomes, nanoemulsions, and nanoparticles began to be considered and widely explored. In the early stages of corneal drug development reliable in vitro and ex vivo alternatives, are required, to be in line with the principles of the 3Rs (Replacement, Reduction, and Refinement), with such methods being in addition faster and more ethical alternatives to in vivo studies. The ocular field remains limited to a handful of predictive models for ophthalmic drug permeation. In vitro cell culture models are increasingly used when it comes to transcorneal permeation studies. Ex vivo models using excised animal tissue such as porcine eyes are the model of choice to study corneal permeation and promising advancements have been reported over the years. Interspecies characteristics must be considered in detail when using such models. This review updates the current knowledge about in vitro and ex vivo corneal permeability models and evaluates their advantages and limitations.

Published
2023
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4. A Three-step Process to Isolate Large Quantities of Bioactive Sesquiterpene Lactones from Cichorium intybus L. Roots and Semi-synthesis of Chicory STLs Standards

Author

Francesca Ruggieri, Philippe Hance, Bruna Gioia, Alexandre Biela, Pascal Roussel, Jean-Louis Hilbert, Nicolas Willand, Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 [M2SV], Transfrontalière BioEcoAgro - UMR 1158 [BioEcoAgro], Médicaments et Molécules pour agir sur les Systèmes Vivants (M2SV) - U1177, Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181, Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 (M2SV), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), ANR-16-IDEX-0004,ULNE,ULNE(2016), ANR-20-PAMR-0005,Mustart,Multiparametric Strategies against Antibiotic Resistance in Tuberculosis(2020), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
chicory, sesquiterpene lactones, 13-dihydrolactucin, lactucin, plant extraction, semisynthesis of analytical standards, Pharmaceutical Science, medicinal_chemistry_50, [CHIM.INOR]Chemical Sciences/Inorganic chemistry, Drug Discovery, Molecular Medicine, 11,13-dihydrolactucin
Abstract

Sesquiterpene lactones (STLs) are a large group of terpenoids most commonly found in plants of the Asteraceae family, e.g., in chicory plants, displaying a wide range of interesting biological activities. However, further studies on the biological potential of chicory-derived STLs and analogues are challenging as only four of these molecules are commercially available (as analytical standards), and to date, there are no published or patented simple extraction–purification processes capable of large-scale STLs isolation. In this work, we describe a novel three-step large-scale extraction and purification method for the simultaneous purification of 11,13-dihydrolactucin (DHLc) and lactucin (Lc) starting from a chicory genotype rich in these STLs and the corresponding glucosyl and oxalyl conjugated forms. After a small-scale screening on 100 mg of freeze-dried chicory root powder, the best results were achieved with a 17 h water maceration at 30 °C. With these conditions, we managed to increase the content of DHLc and Lc, at the same time favoring the hydrolysis of their conjugated forms. On a larger scale, the extraction of 750 g of freeze-dried chicory root powder, followed by a liquid–liquid extraction step and a reversed-phase chromatography, allowed the recovery of 642.3 ± 76.3 mg of DHLc and 175.3 ± 32.9 mg of Lc. The two pure STLs were subsequently used in the context of semisynthesis to generate analogues for biological evaluation as antibacterial agents. In addition, other described chicory STLs that are not commercially available were also synthesized or extracted to serve as analytical standards for the study. In particular, lactucin-oxalate and 11,13-dihydrolactucin-oxalate were synthesized in two steps starting from Lc and DHLc, respectively. On the other hand, 11β,13-dihydrolactucin-glucoside was obtained after a MeOH/H2O (70/30) extraction, followed by a liquid–liquid extraction step and a reversed-phase chromatography. Together, this work will help facilitate the evaluation of the biological potential of chicory-derived STLs and their semisynthetic analogues.

Published
2023
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5. Natural Organic Matter Membrane Fractionation: A new Approach

Author

Dejaeger, Karlien, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
[CHIM.OTHE]Chemical Sciences/Other
Abstract

International audience

Published
2022

6. Additively Manufactured Magnesium-Based Bio-Implants and their Challenges

Author

Rajashekhara Shabadi, Devadas Bhat Panemangalore, Manisha Behera, Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), National Institute of Technology Karnataka, Post Srinivasnagar, Surathkal, Mangalore, India (Department of Metallurgical and Materials Engineering, ), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
Engineering, chemistry, business.industry, Magnesium, Process (engineering), Natural bone, Human anatomy, chemistry.chemical_element, Manufacturing methods, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Process engineering, business
Abstract

Manufacturing structures mimicking the complex geometries of natural bone are in high demand in biomedical research. Additive manufacturing (AM) is an emerging technique for fabricating implant materials for biomedical applications because of its potential to achieve complex structures that are easily modulable and adaptable to human anatomy. This research paper reviews the need of switching from conventional manufacturing methods to AM and discusses some studies made on additively manufactured implants based on magnesium alloys. Although AM techniques are touted to be the more versatile manufacturing method, this paper critically communicates the shortcomings of it, in terms of process parameters, shortcomings of working with magnesium, microstructural and metallurgical defects.

Published
2021
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7. How do haloacetamides and haloacetic acids affect human intestinal epithelial cells?

Author

Dejaeger, K, Criquet, Justine, Vanoppen, M, Cornelissen, E, Billon, G, Vignal, C, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculty of Bioscience Engineering [Ghent], Universiteit Gent = Ghent University (UGENT), European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019), CRIQUET, JUSTINE, Dejaeger, Karlien, and IWA

Subjects
Inflammation, [CHIM.ANAL] Chemical Sciences/Analytical chemistry, [SDE.IE]Environmental Sciences/Environmental Engineering, [SDE.MCG]Environmental Sciences/Global Changes, drinking water, disinfection-by-products, Caco-2, [SDU.ENVI] Sciences of the Universe [physics]/Continental interfaces, environment, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, [SDE.MCG] Environmental Sciences/Global Changes, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Medicine and Health Sciences, gene expression, cytotoxicity, [SDE.IE] Environmental Sciences/Environmental Engineering, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

International audience; In this research, human intestinal epithelial cells (Caco-2) were exposed to haloacetamides and haloacetic acids. A 24, 48 and 72h exposure was conducted to determine the cytotoxicity of these compounds. The unregulated haloacetamides were clearly more cytotoxic than the regulated haloacetic acids. Moreover, changing the halogen from Cl to I increased the toxicity extensively. A 6h stimulation with 1 µM of each compound and subsequent RNA extraction showed high upregulation of genes involved in both oxidative stress and inflammatory pathways with haloacetamide exposure, while no significant changes were seen for haloacetic acid exposure.

Published
2022

8. Disinfection by-products in drinking water: Where do they come from and are they safe to drink?

Author

Dejaeger, Karlien, Vignal, Cécile, Criquet, Justine, Vanoppen, Marjolein, Cornelissen, Emile, Billon, Gabriel, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculty of Bioscience Engineering [Ghent], Universiteit Gent = Ghent University (UGENT), Centre for Advanced Process Technology for Urban Resource Recovery (CAPTURE), KWR Watercycle Research Institute, IWA, European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019), Dejaeger, Karlien, and CRIQUET, JUSTINE

Subjects
[PHYS]Physics [physics], [CHIM.ANAL] Chemical Sciences/Analytical chemistry, chlorination, [SDE.IE]Environmental Sciences/Environmental Engineering, [SDE.MCG]Environmental Sciences/Global Changes, drinking water, Membrane fractionation, [SDU.ENVI] Sciences of the Universe [physics]/Continental interfaces, environment, Modelling, [PHYS] Physics [physics], [SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDE.MCG] Environmental Sciences/Global Changes, Disinfection by-products, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDE.IE] Environmental Sciences/Environmental Engineering, DBPs, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, ComputingMilieux_MISCELLANEOUS
Abstract

International audience; During drinking water disinfection, potentially harmful disinfection by-products are formed due to the reaction of organic matter with chlorine. Therefore, in this research, human intestinal epithelial cells (Caco-2) were exposed to haloacetamides (HAcAm) and haloacetic acids (HAAs). A 24, 48 and 72h exposure was conducted to determine the cytotoxicity of these compounds. The unregulated HAcAms were clearly more cytotoxic than the regulated HAAs. Moreover, changing the halogen from Cl to I increased the toxicity extensively. Hence, a membrane fractionation process is developed to split organic matter into three fractions which should facilitate the identification of both HAA and HAcAm precursors after chlorination.

Published
2022

9. Disinfection by-products in drinking water - Precursor identification and hazard assessment

Author

Dejaeger, Karlien, Criquet, Justine, Vanoppen, Marjolein, Vignal, Cécile, Billon, Gabriel, Cornelissen, Emile, Dejaeger, Karlien, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculty of Bioscience Engineering [Ghent], Universiteit Gent = Ghent University (UGENT), and European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019)

Subjects
[PHYS]Physics [physics], [SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [PHYS] Physics [physics]
Abstract

International audience

Published
2022

10. Natural organic matter membrane fractionation of surface water – A new approach

Author

Dejaeger, Karlien, Criquet, Justine, Vanoppen, Marjolein, Vignal, Cécile, Billon, Gabriel, Cornelissen, Emile, Institute for Translational Research in Inflammation - U 1286 (INFINITE (Ex-Liric)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Avancé de Spectroscopie pour les Intéractions la Réactivité et l'Environnement - UMR 8516 (LASIRE), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Faculty of Bioscience Engineering [Ghent], Universiteit Gent = Ghent University (UGENT), Centre for Advanced Process Technology for Urban Resource Recovery (CAPTURE), Géosystèmes - UMR 8157, Université de Lille, Sciences et Technologies-Centre National de la Recherche Scientifique (CNRS), European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019), and Dejaeger, Karlien

Subjects
[MATH.MATH-OC] Mathematics [math]/Optimization and Control [math.OC], [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC]
Abstract

International audience

Published
2021

11. Natural antibodies:Protecting role of IgM in glioblastoma and brain tumours

Author

Julie Bouckaert, Rabah Boukherroub, Savvas N. Savvides, Shubham Semwal, Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF], NanoBioInterfaces - IEMN [NBI - IEMN], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), The authors acknowledge financial support through the Programme for EArly-stage Researchers in Lille (PEARL), under the auspices of the European Union Horizon 2020 research and innovation programme, project 'ATACA' with Marie Sklodowska-Curie agreement No. 847568. PEARL is coordinated by the Foundation I-SITE ULNE and implemented at the Centre National de la Recherche Scientific (CNRS), European Project: 847568,H2020,H2020-MSCA-COFUND-2018,PEARL(2019), Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Programme for EArly-stage Researchers in Lille (PEARL), under the auspices of the European Union Horizon 2020 research and innovation programmeproject 'ATACA' with Marie Sklodowska-Curie agreement No. 847568. PEARL is coordinated by the Foundation I-SITE ULNE and implemented at the Centre National de la Recherche Scientific (CNRS)., Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Universiteit Gent = Ghent University [Belgium] (UGENT), Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, and Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Subjects
Oncology, MONOCLONAL-ANTIBODY, medicine.medical_treatment, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV]Life Sciences [q-bio], microglia, Disease, 01 natural sciences, IgM, Glioblastoma, Natural Antibodies, Immunotherapy, Microglia, ALK, PHASE-I TRIAL, Drug Discovery, Medicine and Health Sciences, Tumor Microenvironment, Medicine, 0303 health sciences, biology, BARRIER DISRUPTION, Brain Neoplasms, Standard treatment, Astrocytoma, 3. Good health, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, B-CELLS, GLIOMA, immunotherapy, Antibody, medicine.medical_specialty, MEDLINE, PEPTIDE-VACCINE, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, natural antibodies, Internal medicine, Humans, CANCER-CELLS, 030304 developmental biology, Pharmacology, RECEPTOR, business.industry, glioblastoma, Cancer, Biology and Life Sciences, [SDV.IMM.IMM]Life Sciences [q-bio]/Immunology/Immunotherapy, medicine.disease, IMMUNE SURVEILLANCE, LIPID-A ANTIBODY, 0104 chemical sciences, nervous system diseases, 010404 medicinal & biomolecular chemistry, Immunoglobulin M, biology.protein, business
Abstract

Background: Glioblastoma is a grade IV astrocytoma with an average survival span for patients of 18 months after initial diagnosis and no standard treatment protocol is available. Therefore, there is a need to search for novel approaches to target glioblastoma. Objectives: This review intends to capture the role of immunoglobulin-M in cancer, more specifically in glioblastoma multiforme (GBM), and to compile the latest developments and immunological pathways relevant to glioblastoma. Methods: Information on glioblastoma, cancer microenvironment, cancer therapeutics, and how to improve the scenario were obtained from scientific literature databases such as Pubmed, Medline, Google Scholar, Science Direct, Springer, Wiley online library, and some data was harvested from regulatory and compliance databases such as clinicaltrials.gov, FDA database, and WHO Globocan. Results and Conclusions: Currently, only a limited number of therapies are approved for GBM, and no standard care is in place in case of disease relapse, necessitating a possible broader perspective in looking at the disease and its underlying mechanisms.

Published
2021
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