109 results on '"Fast, Pat"'
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2. Finding women in fishing communities around Lake Victoria: "Feasibility and acceptability of using phones and tracking devices".
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Nanyonjo, Gertrude, Kwena, Zachary, Nakamanya, Sarah, Okello, Elialilia, Oketch, Bertha, Bahemuka, Ubaldo M., Ssetaala, Ali, Okech, Brenda, Price, Matt A., Kapiga, Saidi, Fast, Pat, Bukusi, Elizabeth, and Seeley, Janet
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FISHING villages ,FISH communities ,SIM cards ,GPS receivers ,GLOBAL Positioning System - Abstract
Introduction: Women in fishing communities have both high HIV prevalence and incidence, hence they are a priority population for HIV prevention and treatment interventions. However, their mobility is likely to compromise the effectiveness of interventions. We assessed the acceptability, feasibility and of using phones and global positioning system (GPS) devices for tracking mobility, to inform future health research innovations. Methods: A mult-site formative qualitative study was conducted in six purposively selected Fishing Communities on the shores of Lake Victoria in Kenya, Tanzania, and Uganda. Participants were selected based on duration of stay in the community and frequency of movement. Sixty-four (64) women participated in the study (16 per fishing community). Twenty-four (24) participants were given a study phone; 24 were asked to use their own phones and 16 were provided with a portable GPS device to understand what is most preferred. Women were interviewed about their experiences and recommendations on carrying GPS devices or phones. Twenty four (24) Focus Group Discussions with 8–12 participants were conducted with community members to generate data on community perceptions regarding GPS devices and phones acceptability among women. Data were analyzed thematically and compared across sites/countries. Results: Women reported being willing to use tracking devices (both phones and GPS) because they are easy to carry. Their own phone was preferred compared to a study phone and GPS device because they were not required to carry an additional device, worry about losing it or be questioned about the extra device by their sexual partner. Women who carried GPS devices suggested more sensitization in communities to avoid domestic conflicts and public concern. Women suggested changing the GPS colour from white to a darker colour and, design to look like a commonly used object such as a telephone Subscriber Identity Module (SIM) card, a rosary/necklace or a ring for easy and safe storage. Conclusion: Women in the study communities were willing to have their movements tracked, embraced the use of phones and GPS devices for mobility tracking. Devices need to be redesigned to be more discrete, but they could be valuable tools to understanding movement patterns and inform design of interventions for these mobile populations. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses
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Muir, Roshell, primary, Metcalf, Talibah, additional, Fourati, Slim, additional, Bartsch, Yannic, additional, Kyosiimire-Lugemwa, Jacqueline, additional, Canderan, Glenda, additional, Alter, Galit, additional, Muyanja, Enoch, additional, Okech, Brenda, additional, Namatovu, Teddy, additional, Namara, Irene, additional, Namuniina, Annemarie, additional, Ssetaala, Ali, additional, Mpendo, Juliet, additional, Nanvubya, Annet, additional, Kitandwe, Paul Kato, additional, Bagaya, Bernard S., additional, Kiwanuka, Noah, additional, Nassuna, Jacent, additional, Biribawa, Victoria Menya, additional, Elliott, Alison M., additional, de Dood, Claudia J., additional, Senyonga, William, additional, Balungi, Priscilla, additional, Kaleebu, Pontiano, additional, Mayanja, Yunia, additional, Odongo, Matthew, additional, Connors, Jennifer, additional, Fast, Pat, additional, Price, Matt A., additional, Corstjens, Paul L. A. M., additional, van Dam, Govert J., additional, Kamali, Anatoli, additional, Sekaly, Rafick Pierre, additional, and Haddad, Elias K., additional
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- 2023
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4. Schistosoma mansoniinfection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses
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Muir, Roshell, primary, Metcalf, Talibah, additional, Fourati, Slim, additional, Bartsch, Yannic, additional, Lugemwa, Jacqueline Kyosiimire, additional, Canderan, Glenda, additional, Alter, Galit, additional, Muyanja, Enoch, additional, Okech, Brenda, additional, Namatovu, Teddy, additional, Namara, Irene, additional, Namuniina, Annemarie, additional, Ssetaala, Ali, additional, Mpendo, Juliet, additional, Nanvubya, Annet, additional, Kitandwe, Paul Kato, additional, Bagaya, Bernard S., additional, Kiwanuka, Noah, additional, Nassuna, Jacent, additional, Biribawa, Victoria Menya, additional, Elliott, Alison M., additional, de Dood, Claudia J., additional, Senyonga, William, additional, Balungi, Priscilla, additional, Kaleebu, Pontiano, additional, Mayanja, Yunia, additional, Odongo, Mathew, additional, Fast, Pat, additional, Price, Matt A., additional, Corstjens, Paul L.A.M., additional, van Dam, Govert J., additional, Kamali, Anatoli, additional, Sekaly, Rafick Pierre, additional, and Haddad, Elias K, additional
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- 2023
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5. HIV vaccine-induced sero-reactivity: A challenge for trial participants, researchers, and physicians
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Voronin, Yegor, Zinszner, Helene, Karg, Carissa, Brooks, Katie, Coombs, Robert, Hural, John, Holt, Renee, Fast, Pat, Allen, Mary, Busch, Michael, Fruth, Ulrich, Golding, Hana, Khurana, Surender, Mulenga, Joseph, Peel, Sheila, Schito, Marco, Barnabas, Nomampondo, Bentsen, Christopher, Graham, Barney, Gray, Glenda, Levin, Andrew, McCluskey, Margaret, O’Connell, Robert, Snow, Bill, and Ware, Mark
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- 2015
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6. Ebola and Aids
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Fast, Pat, primary
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- 2017
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7. Social networks, mobility, and HIV risk among women in the fishing communities of Lake Victoria
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Nakamanya, Sarah, primary, Okello, Elialilia S., additional, Kwena, Zachary A, additional, Nanyonjo, Gertrude, additional, Bahemuka, Ubaldo M, additional, Kibengo, Freddie M, additional, Ssetaala, Ali, additional, Bukusi, Elizabeth, additional, Kapiga, Saidi, additional, Fast, Pat, additional, Seeley, Janet, additional, and Kidega, The Lake Victoria Consortium for Health Research (LVCHR), additional
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- 2022
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8. Measles immunity gap among reproductive-age women participating in a simulated HIV vaccine efficacy trial in Zambia
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Malama, Kalonde, primary, Tichacek, Amanda, additional, Kelly, Hilary, additional, Parker, Rachel, additional, Inambao, Mubiana, additional, Sharkey, Tyronza, additional, Wall, Kristin M., additional, Kilembe, William, additional, Price, Matt A., additional, Fast, Pat, additional, Priddy, Fran, additional, and Allen, Susan, additional
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- 2022
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9. Identifying the immune interactions underlying HLA class I disease associations
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Debebe, Bisrat J, Boelen, Lies, Lee, James C, IAVI Protocol C Investigators, Thio, Chloe L, Astemborski, Jacquie, Kirk, Gregory, Khakoo, Salim I, Donfield, Sharyne M, Goedert, James J, Asquith, Becca, Sanders, Eduard J, Anzala, Omu, Kamali, Anatoli, Kaleebu, Pontiano, Karita, Etienne, Kilembe, William, Inambao, Mubiana, Lakhi, Shabir, Allen, Susan, Hunter, Eric, Edward, Vinodh A, Fast, Pat E, Price, Matt A, Gilmour, Jill, Tang, Jianming, Asquith, Becca [0000-0002-5911-3160], Apollo - University of Cambridge Repository, and Lee, James [0000-0001-5711-9385]
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disease association ,systems biology ,natural killer cell ,immunology ,HLA ,immunogenetics ,computational biology ,Immunology and Inflammation ,CD8 T cell ,inflammation ,GWAS ,Research Article ,Computational and Systems Biology ,Human - Abstract
Variation in the risk and severity of many autoimmune diseases, malignancies and infections is strongly associated with polymorphisms at the HLA class I loci. These genetic associations provide a powerful opportunity for understanding the etiology of human disease. HLA class I associations are often interpreted in the light of 'protective' or 'detrimental' CD8+ T cell responses which are restricted by the host HLA class I allotype. However, given the diverse receptors which are bound by HLA class I molecules, alternative interpretations are possible. As well as binding T cell receptors on CD8+ T cells, HLA class I molecules are important ligands for inhibitory and activating killer immunoglobulin-like receptors (KIRs) which are found on natural killer cells and some T cells; for the CD94:NKG2 family of receptors also expressed mainly by NK cells and for leukocyte immunoglobulin-like receptors (LILRs) on myeloid cells. The aim of this study is to develop an immunogenetic approach for identifying and quantifying the relative contribution of different receptor-ligand interactions to a given HLA class I disease association and then to use this approach to investigate the immune interactions underlying HLA class I disease associations in three viral infections: Human T cell Leukemia Virus type 1, Human Immunodeficiency Virus type 1 and Hepatitis C Virus as well as in the inflammatory condition Crohn's disease.
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- 2020
10. Additional file 1 of Understanding mobility and sexual risk behaviour among women in fishing communities of Lake Victoria in East Africa: a qualitative study
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Kwena, Zachary, Nakamanya, Sarah, Nanyonjo, Gertrude, Elialilia Okello, Fast, Pat, Ssetaala, Ali, Oketch, Bertha, Price, Matt, Saidi Kapiga, Bukusi, Elizabeth, and Seeley, Janet
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Data_FILES - Abstract
Additional file 1.
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- 2020
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11. Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection
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Macharia, Gladys N., primary, Yue, Ling, additional, Staller, Ecco, additional, Dilernia, Dario, additional, Wilkins, Daniel, additional, Song, Heeyah, additional, McGowan, Edward, additional, King, Deborah, additional, Fast, Pat, additional, Imami, Nesrina, additional, Price, Matthew A., additional, Sanders, Eduard J., additional, Hunter, Eric, additional, and Gilmour, Jill, additional
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- 2020
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12. Prevalence and correlates of HIV infection among adolescents and young people living in fishing populations along Lake Victoria Fishing Communities in Uganda
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Nanyonjo, Gertrude, primary, Asiki, Gershim, additional, Ssetaala, Ali, additional, Nakaweesa, Teddy, additional, Wambuzi, Mathias, additional, Nanvubya, Annet, additional, Mpendo, Juliet, additional, Okech, Brenda, additional, Kitandwe, Paul Kato, additional, Nielsen, Leslie, additional, Nalutaaya, Annet, additional, Welsh, Sabrina, additional, Bagaya, Bernard Ssentalo, additional, Chinyenze, Kundai, additional, Fast, Pat, additional, Price, Matt, additional, and Kiwanuka, Noah, additional
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- 2020
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13. PS-003: EVIDENCE-INFORMED POLICY MAKING: CHALLENGES AND OPPORTUNITIES
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Makanga, Michael, Beattie, Pauline, Breugelmans, Gabrielle, Nyirenda, Thomas, Bockarie, Moses, Tanner, Marcel, Volmink, Jimmy, Hankins, Catherine, Walzl, Gerhard, Chegou, Novel, Malherbe, Stephanus, Hatherill, Mark, Scriba, Thomas J., Zak, Daniel E., Barry, Clifton E., Kaufmann, Stefan H.E., Noor, Abdisalan, Strub-Wourgaft, Nathalie, Phillips, Patrick, Munguambe, Khátia, Ravinetto, Raffaella, Tinto, Halidou, Diro, Ermias, Mahendrahata, Yodi, Okebe, Joseph, Rijal, Suman, Garcia, Coralith, Sundar, Shyam, Ndayisaba, Gilles, Sopheak, Thai, Ngoduc, Thang, Loen, Harry Van, Jacobs, Jan, D'Alessandro, Umberto, Boelaert, Marleen, Buvé, Anne, Kamalo, Patrick, Manda-Taylor, Lucinda, Rennie, Stuart, Mokgatla, Boitumelo, Bahati, Prince, Ijsselmuiden, Carel, Afolabi, Muhammed, Mcgrath, Nuala, Kampmann, Beate, Imoukhuede, Egeruan, Alexander, Neal, Larson, Heidi, Chandramohan, Daniel, Bojang, Kalifa, Kasaro, Margaret Phiri, Muluka, Brenda, Kaunda, Kaunda, Morse, Jill, Westfall, Andrew, Kapata, Nathan, Kruuner, Annika, Henostroza, German, Reid, Stewart, Alabi, Abraham, Foguim, Francis, Sankarganesh, Jeyaraj, Bruske, Ellen, Mfoumbi, Arnault, Mevyann, Chester, Adegnika, Ayola, Lell, Bertrand, Kranzer, Katharina, Kremsner, Peter, Grobusch, Martin, Sabiiti, Wilber, Ntinginya, Nyanda, Kuchaka, Davis, Azam, Khalide, Kampira, Elizabeth, Mtafya, Bariki, Bowness, Ruth, Bhatt, Nilesh, Davies, Gerry, Kibiki, Gibson, Gillespie, Stephen, Lejon, Veerle, Ilboudo, Hamidou, Mumba, Dieudonné, Camara, Mamady, Kaba, Dramane, Lumbala, Crispin, Fèvre, Eric, Jamonneau, Vincent, Bucheton, Bruno, Büscher, Philippe, Chisenga, Caroline, Sinkala, Edford, Chilengi, Roma, Chitundu, Hellen, Zyambo, Zude, Wandeler, Gilles, Vinikoor, Michael, Emilie, Dama, Camara, Oumou, Mathurin, Koffi, Guiguigbaza-Kossigan, Dayo, Philippe, Büscher, Regassa, Fikru, Hassane, Sakande, Bienvenu, Somda Martin, Fabrice, Courtin, Ouédraogo, Elie, Kouakou, Lingue, Owusu, Michael, Mensah, Eric, Enimil, Anthony, Mutocheluh, Mohamed, Ndongo, Francis Ateba, Tejiokem, Mathurin Cyrille, Texier, Gaetan, Penda, Calixte, Ndiang, Suzie, Ndongo, Jean-Audrey, Guemkam, Georgette, Sofeu, Casimir Ledoux, Afumbom, Kfutwa, Faye, Albert, Msellati, Philippe, Warszawski, Josiane, Vos, Alinda, Devillé, Walter, Barth, Roos, Klipstein-Grobusch, Kerstin, Tempelman, Hugo, Venter, François, Coutinho, Roel, Grobbee, Diederick, Ssemwanga, Deogratius, Lyagoba, Frederick, Magambo, Brian, Kapaata, Anne, Kirangwa, Joseph, Nannyonjo, Maria, Nassolo, Faridah, Nsubuga, Rebecca, Yebra, Gonzalo, Brown, Andrew, Kaleebu, Pontiano, Nylén, Hanna, Habtewold, Abiy, Makonnen, Eyasu, Yimer, Getnet, Burhenne, Jürgen, Diczfalusy, Ulf, Aklillu, Eleni, Steele, Duncan, Walker, Richard, Simuyandi, Michelo, Beres, Laura, Bosomprah, Samuel, Ansumana, Rashid, Taitt, C., Lamin, J.M., Jacobsen, K.H., Mulvaney, S.P., Leski, T., Bangura, U., Stenger, D., Vries, Sophie De, Zinsou, Frejus Jeannot, Honkpehedji, J, Dejon, Jean Claude, Loembe, Marguerite Massinga, Bache, Bache, Pakker, Nadine, Leeuwen, Remko Van, Hounkpatin, Aurore Bouyoukou, Yazdanbakhsh, Maria, Bethony, Jeffrey, Hotez, Peter, Diemert, David, Bache, Bache Emmanuel, Fernandes, José F., Mba, Régis M Obiang, Kabwende, Anita L., Grobusch, Martin P., Krishna, Sanjeev, Kremsner, Peter G., Todagbe, Agnandji Selidji, Nambozi, Michael, Kabuya, Jean-Bertin, Hachizovu, Sebastian, Mwakazanga, David, Kasongo, Webster, Buyze, Jozefien, Mulenga, Modest, Geertruyden, Jean-Pierre, Gitaka, Jesse, Chan, Chim, Kongere, James, Kagaya, Wataru, Kaneko, Akira, Kabore, Naomie, Barry, Nouhoun, Kabre, Zachari, Werme, Karidia, Fofana, Aminata, Compaore, Daniel, Nikiema, Frederic, Some, Fabrice, Djimde, Abdoulaye, Zongo, Issaka, Ouedraogo, Bosco, Kone, Aminatou, Sagara, Issaka, Björkman, Anders, Gil, Jose Pedro, Nchinda, Godwin, Bopda, Alain, Nji, Nadesh, Ambada, Georgia, Ngu, Loveline, Tchadji, Jules, Sake, Carol, Magagoum, Suzanne, Njambe, Ghislain D., Lisom, Abel, Park, Chae Gyu, Tait, Dereck, Sibusiso, Hlatjwako, Manda, Olga, Croucher, Kristin, Westhuizen, Anja Van Der, Mshanga, Isaac, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, Pantaleo, Giuseppe, Ngasala, Billy, Jovel, Irina, Malmberg, Maja, Mmbando, Bruno, Premji, Zul, Mårtensson, Andreas, Mwaiswelo, Richard, Agbor, Lenshina, Apinjoh, Tobias, Mwanza, Sydney, Chileshe, Justin, Joshi, Sudhaunshu, Malunga, Phidelis, Manyando, Christine, Laufer, Miriam, Dara, Antoine, Niangaly, Amadou, Sinha, Indranil, Brodin, David, Fofana, Bakary, Dama, Souleymane, Dembele, Demba, Sidibe, Bakary, Diallo, Nouhoum, Thera, Mahamadou, Wright, Karin, Gil, Jose, Doumbo, Ogobara, Baraka, Vito, Nabasumba, Carolyn, Francis, Filbert, Lutumba, Pascal, Mavoko, Hypolite, Alifrangis, Michael, Geertruyden, Jean-Pierre Van, Sissoko, Sekou, Sangaré, Cheick, Toure, Sekou, Sanogo, Kassim, Diakite, Hamadoun, Toure, Siaka, Doumbia, Diagassan, Haidara, Kadiatou, Julé, Amélie, Ashurst, Hazel, Merson, Laura, Olliaro, Piero, Marsh, Vicki, Lang, Trudie, Guérin, Philippe, Awuondo, Kennedy, Njenga, Daniel, Nyakarungu, Elizabeth, Titus, Pauline, Sutamihardja, Awalludin, Lowe, Brett, Ogutu, Bernhards, Billingsley, Peter, Soulama, Issiaka, Kaboré, Moïse, Coulibaly, Aboubacar, Ouattara, Maurice, Sanon, Souleymane, Diarra, Amidou, Bougouma, Edith, Ouedraogo, Alphonse, Sombie, Benjamin, Ouedraogo, Amidou, Kargougou, Désiré, Ouattara, Daouda, Issa, Nebie, Tiono, Alfred, Sirima, Sodiomon, Chaponda, Mike, Dabira, Edgard, Dao, François, Dara, Nianwalou, Sidibe, Bouran, Coulibaly, Moctar, Tolo, Allaye, Maiga, Hamma, Ouologuem, Nouhoum, Niangaly, Hamidou, Botchway, Felix, Wilson, Nana, Dickinson-Copeland, Carmen M, Adjei, Andrew A., Wilson, Michael, Stiles, Jonathan K., Hamid, Muzamil Abdel, Awad-Elgeid, Mona, Nasr, Awad, Netongo, Palmer, Kamdem, Séverin, Velavan, Thirumalaisamy, Lasry, Estrella, Diarra, Modibo, Bamadio, Amadou, Traore, Aliou, Coumare, Samba, Soma, Bahonan, Dicko, Yeyia, Sangare, Boubou, Tembely, Aly, Traore, Djibril, Haidara, Aboubecrin, Dicko, Alassane, Diawara, Elisabeth, Beavogui, Abdoul, Camara, Daouda, Sylla, Malick, Yattara, Mohamed, Sow, Amadou, Camara, Gnèpou Camara, Diallo, Saliou, Mombo-Ngoma, Ghyslain, Remppis, Jonathan, Sievers, Moritz, Manego, Rella Zoleko, Endamne, Lilian, Hutchinson, David, Held, Jana, Supan, Christian, Salazar, Carmen L. Ospina, Bonkian, Léa Nadège, Nahum, Alain, Sié, Ali, Abdulla, Salim, Cantalloube, Cathy, Djeriou, Elhadj, Bouyou-Akotet, Marielle, Mordmüller, Benjamin, Siribie, Mohamadou, Sirima, Sodiomon B., Ouattara, San Maurice, Coulibaly, Sam, Kabore, Jean Moïse, Amidou, Diarra, Tekete, Mamadou, Burhenne, Juergen, Traore, Oumar, Haefeli, Walter, Borrmann, Steffen, Kaboré, Naomie, Kabré, Zachari, Nikèma, Fréderic, Compaoré, Daniel, Somé, Fabrice, Djimdé, Abdoulaye, Ouédraogo, Jean, Chalwe, Victor, Miller, John, Diakité, Hamadoun, Greco, Beatrice, Spangenberg, Thomas, Kourany-Lefoll, Elly, Oeuvray, Claude, Mulry, Jim, Tyagarajan, Kamala, Magsaam, Bettina, Barnes, Karen, Hodel, Eva Maria, Humphreys, Georgina, Pace, Cheryl, Banda, C.G, Denti, Paulo, Allen, Elizabeth, Lalloo, David, Mwapasa, Victor, Terlouw, Anja, Mwesigwa, Julia, Achan, Jane, Jawara, Musa, Ditanna, Gian, Worwui, Archibald, Affara, Muna, Koukouikila-Koussounda, Félix, Kombo, Michael, Vouvoungui, Christevy, Ntoumi, Francine, Etoka-Beka, Mandingha Kosso, Deibert, Julia, Poulain, Pierre, Kobawila, Simon, Gueye, Nerly Gampio, Koukouikila-Koussounda, Felix, Seda, Brian, Kwambai, Titus, Jangu, Phelix, Samuels, Aaron, ter Kuile, Feike, Kariuki, Simon, Barry, Aissata, Bousema, Teun, Okech, Brenda, Egwang, Thomas, Corran, Patrick, Riley, Eleanor, Ezennia, Ifeoma, Ekwunife, Obinna, Muleba, Mbanga, Stevenson, Jennifer, Mbata, Keith, Coetzee, Maureen, Norris, Douglas, Moneke-Anyanwoke, Ngozi, Momodou, Jasseh, Clarke, Ed, Scott, Susana, Tijani, Adelani, Djimde, Moussa, Vaillant, Michel, Samouda, Hanen, Mensah, Victorine, Roetynck, Sophie, Kanteh, Ebrima, Bowyer, Georgina, Ndaw, Amy, Oko, Francis, Bliss, Carly, Jagne, Ya Jankey, Cortese, Riccardo, Nicosia, Alfredo, Roberts, Rachel, D'Alessio, Flavia, Leroy, Odile, Faye, Babacar, Cisse, Badara, Gerry, Stephen, Viebig, Nicola, Lawrie, Alison, Ewer, Katie, Hill, Adrian, Nebie, Issa, Tiono, Alfred B, Sanou, Guillaume, Konate, Amadou T, Yaro, Baptiste J, Sodiomon, Sirima, Honkpehedji, Yabo, Agobe, Jean Claude Dejon, Zinsou, Frejus, Mengue, Juliana, Richie, Thomas, Hoffman, Stephen, Nouatin, Odilon, Ngoa, Ulysse Ateba, Edoa, Jean R, Homoet, Andreas, Engelhon, Julie Englhon, Massinga-Louembe, Marguerite, Esen, Meral, Theisen, Michael, Sim, Kim Lee, Luty, Adrian Jf, Moutairou, Kabirou, Dinko, Bismarck, King, Elizabeth, Targett, Geoffrey, Sutherland, Colin, Likhovole, Clement, Ouma, Collins, Vulule, John, Musau, Susan, Khayumbi, Jeremiah, Okumu, Albert, Murithi, Wilfred, Otu, Jacob, Gehre, Florian, Zingue, Dezemon, Kudzawu, Samuel, Forson, Audrey, Mane, Morto, Rabna, Paulo, Diarra, Bassirou, Kayede, Salako, Adebiyi, Emmanuel, Kehinde, Aderemi, Onyejepu, Nneka, Onubogu, Catherine, Idigbe, Emmanuel, Ba, Awa, Diallo, Aissatou, Mboup, Souleymane, Disse, Kodjo, Kadanga, Gerard, Dagnra, Yaotse, Baldeh, Ignatius, Corrah, Tumani, Jong, Bouke De, Antonio, Martin, Musanabaganwa, Clarisse, Musabyimana, Jean Pierre, Karita, Etienne, Diop, Blondin, Nambajimana, Abidan, Dushimiyimana, Valentine, Karame, Prosper, Russell, Jim, Ndoli, Jules, Hategekimana, Theobald, Sendegeya, Augustin, Condo, Jeannine, Binagwaho, Agnes, Okonko, Iheanyi, Okerentugba, Phillip, Opaleye, Oluyinka, Awujo, Ezinwanne, Frank-Peterside, Nnenna, Moyo, Sikhulile, Kotokwe, Kenanao, Mohammed, Terence, Boleo, Coretah, Mupfumi, Lucy, Chishala, Samuel, Gaseitsiwe, Simani, Tsalaile, Lesedi, Bussmann, Herman, Makhema, Joseph, Baum, Marianna, Marlink, Richard, Engelbretch, Susan, Essex, Max, Novitsky, Vladimir, Saka, Emmanuel, Kalipalire, Zex, Bhairavabhotla, Ravikiran, Midiani, Dalitso, Sherman, Judith, Mgode, Georgies, Cox, Christophe, Bwana, Dickens, Mtui, Leah, Magesa, Daniel, Kahwa, Amos, Mfinanga, Godfrey, Mulder, Christiaan, Borain, Nick, Petersen, Lizette, Plessis, Julianne Du, Theron, Grant, Holm-Hansen, Carol, Tekwu, Emmanuel Mouafo, Sidze, Larissa Kamgue, Assam, Jean Paul Assam, Eyangoh, Sarah, Niemann, Stefan, Beng, Veronique Penlap, Frank, Matthias, Atiadeve, Samuel, Hilmann, Doris, Awoniyi, Dolapo, Baumann, Ralf, Kriel, Belinda, Jacobs, Ruschca, Kidd, Martin, Loxton, Andre, Kaempfer, Susanne, Singh, Mahavir, Mwanza, Winnie, Milimo, Deborah, Moyo, Maureen, Kasese, Nkatya, Cheeba-Lengwe, Maina, Munkondya, Stembiso, Ayles, Helen, Haas, Petra De, Muyoyeta, Monde, Namuganga, Anna Ritah, Kizza, Harriet Mayanja, Mendy, Alieu, Tientcheu, Leopold, Ayorinde, Abigail, Coker, Edward, Egere, Uzochukwu, Coussens, Anna, Naude, Celeste, Chaplin, George, Noursadeghi, Mahdad, Martineau, Adrian, Jablonski, Nina, Wilkinson, Robert, Ouedraogo, Henri Gautier, Matteelli, Alberto, Regazzi, Mario, Tarnagda, Grissoum, Villani, Paola, Sulis, Giorgia, Diagbouga, Serge, Roggi, Alberto, Giorgetti, Francesco, Kouanda, Seni, Bidias, Amel, Ndjonka, Dieudonné, Olemba, Clémence, Souleymanou, Arabo, Mukonzo, Jackson, Kuteesa, Ronald, Ogwal-Okeng, Jasper, Gustafsson, Lars L., Owen, Joel, Bassi, Peter, Gashau, Wadzani, Olaf, Klungel, Dodoo, Alexander, Okonkwo, Prosper, Kanki, Phyllis, Maruapula, Dorcas, Seraise, Boitumelo, Einkauf, Kevin, Reilly, Amanda, Rowley, Christopher, Musonda, Rosemary, Framhein, Anna, Mpagama, Stella, Semvua, Hadija, Maboko, Leonard, Hoelscher, Michael, Heinrich, Norbert, Mulenga, Lloyd, Kaayunga, Callistus, Davies, Mary-Ann, Egger, Matthias, Musukuma, Kalo, Dambe, Rosalia, Usadi, Benjamin, Ngari, Moses, Thitiri, Johnstone, Mwalekwa, Laura, Fegan, Greg, Berkley, James, Nsagha, Dickson, Munamunungu, Virginia, Bolton, Carolyn, Siyunda, Alice, Shilimi, Jacinta, Bucciardini, Raffaella, Fragola, Vincenzo, Abegaz, Teshome, Lucattini, Stefano, Halifom, Atakilt, Tadesse, Eskedar, Berhe, Micheal, Pugliese, Katherina, Castro, Paola De, Terlizzi, Roberta, Fucili, Luca, Gregorio, Massimiliano Di, Mirra, Marco, Zegeye, Teame, Binelli, Andrea, Vella, Stefano, Abraham, Loko, Godefay, Hagos, Rakotoarivelo, Rivo, Raberahona, Mihaja, Randriamampionona, Njary, Andriamihaja, Rabezanahary, Rasamoelina, Tahinamandranto, Cornet, Muriel, Randria, Mamy Jean De Dieu, Benet, Thomas, Vanhems, Philippe, Andrianarivelo, Mala Rakoto, Chirwa, Uchizi, Michelo, Charles, Hamoonga, Raymond, Wandiga, Steve, Oduor, Patience, Agaya, Janet, Sharma, Aditya, Cavanaugh, Sean, Cain, Kevin, Mukisa, John, Mupere, Ezekiel, Worodria, William, Ngom, Justice Trésor, Koro, Francioli, Godwe, Celestin, Adande, Clemence, Ateugieu, Romaric, Onana, Tatiana, Ngono, Annie, Kamdem, Yannick, Ngo-Niobe, Sara, Etoa, François-Xavier, Kanengoni, Muchineripi, Ruzario, Sithembile, Ndebele, Paul, Shana, Melody, Tarumbiswa, Fadzai, Musesengwa, Rosemary, Gutsire, Rutendo, Fisher, Kevin, Thyagarajan, Bargavi, Akanbi, Olusola, Binuyo, Michael, Ssengooba, Willy, Respeito, Durval, Mambuque, Edson, Blanco, Silvia, Mandomando, Inacio, Cobelens, Frank, Garcia-Basteiro, Alberto, Tamene, Ayele, Topp, Stephanie, Mwamba, Chanda, Padian, Nancy, Sikazwe, Izukanji, Geng, Elvin, Holmes, Charles, Sikombe, Kombatende, Hantuba, Cardinal, Czaicki, Nancy, Simbeza, Sandra, Somwe, Paul, Umulisa, Michele, Ilo, Jennifer, Kestelyn, Evelyne, Uwineza, Mireille, Agaba, Stephen, Delvaux, Therese, Wijgert, Janneke, Gethi, Dickson, Odeny, Lazarus, Tamandjou, Cynthia, Kaindjee-Tjituka, Francina, Brandt, Laura, Cotton, Mark, Nel, Etienne, Preiser, Wolfgang, Andersson, Monique, Adepoju, Abiola, Magana, Musa, Etsetowaghan, Andrew, Chilikwazi, Mutinta, Sutcliffe, Catherine, Thuma, Philip, Sinywimaanzi, Kathy, Matakala, Hellen, Munachoonga, Passwell, Moss, William, Masenza, Issa Sabi, Geisenberger, Otto, Agrea, Peter, Rwegoshora, France, Mahiga, Hellen, Olomi, Willyhelmina, Kroidl, Arne, Kayode, Gbenga, Amoakoh-Coleman, Mary, Ansah, Evelyn, Uthman, Olalekan, Fokam, Joseph, Santoro, Maria-Mercedes, Musolo, Chrissie, Chimbiri, Isabel, Chikwenga, Gloria, Deula, Ruth, Massari, Riccardo, Lungu, Agness, Perno, Carlo-Federico, Ndzengue, Georgia, Loveline, Ngu, Lissom, Abel, Flaurent, Tchouangueu, Sosso, Samuel, Essomba, Claudine, Kpeli, Grace, Otchere, Isaac, Lamelas, Araceli, Buultjens, Andrew, Bulach, Dieter, Baines, Sarah, Seemann, Torsten, Giulieri, Stefano, Nakobu, Zuliehatu, Aboagye, Samuel, Owusu-Mireku, Evelyn, Danso, Emelia, Hauser, Julia, Hinic, Vladimira, Pluschke, Gerd, Stinear, Timothy, Yeboah-Manu, Dorothy, Elshayeb, Ayman, Siddig, Marmar El, Ahmed, Abdel Azim, Hussien, Adil El, Kabwe, Mwila, Tembo, John, Chilukutu, Lophina, Chilufya, Moses, Ngulube, Francis, Lukwesa, Chileshe, Enne, Virve, Wexner, Hannah, Mwananyanda, Lawrence, Hamer, Davidson, Sinyangwe, Sylvester, Ahmed, Yusuf, Klein, Nigel, Maeurer, Markus, Zumla, Ali, Bates, Matthew, Beyala, Landry, Etienne, Guenou, Anthony, Njimbia, Benjamin, Azike, Ateudjieu, Jerome, Chibwe, Bertha, Ojok, David, Tarr, Christine Attia, Perez, Guillermo Martinez, Omeonga, Senga, Kibungu, Fanta, Meyer, Ana, Lansana, Peter, Mayor, Alfredo, Onyango, Peter, Loggerenberg, François Van, Furtado, Tamzin, Boggs, Liam, Segrt, Alexis, Dochez, Carine, Burnett, Rosemary, Mphahlele, M. Jeffrey, Miiro, George, Mbidde, Edward, Peshu, Norbert, Kivaya, Esther, Ngowi, Bernard, Kavishe, Reginald, Maowia, Mukhtar, Sandstrom, Eric, Ayuo, Elizabeth, Mmbaga, Blandina, Leisegang, Cordelia, Thorpe, Marie, Batchilly, Elizabeth, N'Guessan, Jean-Pierre, Kanteh, Dembo, Søfteland, Solrun, Sebitloane, Motshedisi, Vwalika, Bellington, Taylor, Myra, Galappaththi-Arachchige, Hashini, Holmen, Sigve, Gundersen, Svein Gunnar, Ndhlovu, Patricia, Kjetland, Eyrun Floerecke, Kombe, Francis, Toohey, Jacintha, Pienaar, Elizabeth, Kredo, Tamara, Cham, Pa Modou, Abubakar, Ismaela, Dondeh, Bai Lamin, Vischer, Nerina, Pfeiffer, Constanze, Burri, Christian, Musukwa, Kalo, Zürcher, Samuel, Mwandu, Temwani, Bauer, Sophie, Adriko, Moses, Mwaura, Peter, Omolloh, Kevin, Jones, Clarer, Malecela, Mwelecele, Hamidu, Buhari Adamu, Jenner, Tettevi Edward, Asiedu, Larbi John, Osei-Atweneboana, Mike, Afeke, Innocent, Addo, Phyllis, Newman, Mercy, Durnez, Lies, Eddyani, Miriam, Ammisah, Nana, Abas, Mona, Quartey, Maxwell, Ablordey, Anthony, Akinwale, Olaoluwa, Adeneye, Adeniyi, Ezeugwu, Sylvanus, Olukosi, Yetunde, Adewale, Babatunde, Sulyman, Medinat, Mafe, Margaret, Okwuzu, Jane, Gyang, Pam, Nwafor, Timothy, Henry, Uzoma, Musa, Bilkisu, Ujah, Innocent, Agobé, Jean Claude Dejon, Grau-Pujol, Berta, Sacoor, Charfudin, Nhabomba, Augusto, Casellas, Aina, Quintó, Llorenç, Subirà, Carme, Giné, Ricard, Valentín, Antònia, Muñoz, Jose, Nikiema, Marguerite, Ky-Ba, Absatou, Comapore, Kiswendsida Abdou Muller, Traore, Alfred, Sangare, Lassana, Oluremi, Adeolu, Michel, Mandro, Camara, Yaya, Sanneh, Bakary, Cuamba, Inocencia, Gutiérrez, Jose, Lázaro, Carlota, Mejia, Rojelio, Adedeji, Abimbola, Folorunsho, Sola, Demehin, Pelumi, Akinsanya, Bamidele, Cowley, Giovanna, Silva, Eunice Teixeira Da, Nabicassa, Meno, Barros, Pedrozinho Duarte Pereira De, Blif, Milena Mbote, Bailey, Robin, Last, Anna, Mahendradhata, Yodi, Gotuzzo, Eduardo, Nys, Kateljine De, Casteels, Minnes, Nona, Sylvie Kwedi, Lumeka, Kabwende, Todagbe, Agnandji, Djima, Mariam Mama, Ukpong, Morenike, Sagay, Atiene, Khamofu, Hadiza, Torpey, Kwasi, Afiadigwe, Evaristus, Anenih, James, Ezechi, Oliver, Nweneka, Chidi, Idoko, John, Muhumuza, Simon, Katahoire, Anne, Nuwaha, Fred, Olsen, Annette, Okeyo, Seth, Omollo, Raymond, Kimutai, Robert, Ochieng, Michael, Egondi, Thaddaeus, Moonga, Clement, Chileshe, Chisele, Magwende, George, Anumudu, Chiaka, Onile, Olugbenga, Oladele, Victoria, Adebayo, Adewale, Awobode, Henrietta, Oyeyemi, Oyetunde, Odaibo, Alexander, Kabuye, Emily, Lutalo, Tom, Njua-Yafi, Clarisse, Nkuo-Akenji, Theresa, Anchang-Kimbi, Judith, Mugri, Regina, Chi, Hanesh, Tata, Rolland, Njumkeng, Charles, Dodoo, Daniel, Achidi, Eric, Fernandes, José, Bache, Emmanuel B., Matakala, Kalumbu, Searle, Kelly, Greenman, Michelle, and Rainwater-Lovett, Kaitlin
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Abstracts of Poster Presentations ,Abstracts of Oral Presentations ,Author Index ,Abstracts of Presentations in Plenary Sessions ,Article ,Abstracts of the Eighth Edctp Forum, 6–9 November 2016 - Published
- 2017
14. Retention of adults from fishing communities in an HIV vaccine preparedness study in Masaka, Uganda
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Bahemuka, Ubaldo Mushabe, primary, Abaasa, Andrew, additional, Ruzagira, Eugene, additional, Lindan, Christina, additional, Price, Matt A., additional, Kamali, Anatoli, additional, and Fast, Pat, additional
- Published
- 2019
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15. THE RESULTS OF THE EV06 DNA-PROTEIN COMBINATION TRIAL AND PLANS FOR GREAT, AN EDCTP2-FUNDED CONSERVED-MOSAIC EPITOPE HIV VACCINE TRIAL
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Kaleebu, Pontiano, Levin, Jonathan, Nanvubya, Annet, Kibengo, Freddie, Jaoko, Walter, Pala, Pietro, Perreau, Matthieu, Namuniina, Annemarie, Kitandwe, Paul, Tapia, Gonzalo, Serwanga, Jennifer, Yates, Nicole, Fast, Pat, Mayer, Bryan, Montefiori, David, Tomaras, Georgia, Robb, Merlin, Lee, Carter, Wagner, Ralf, Sanders, Edward, Kilembe, William, Kiwanuka, Noah, Gilmour, Jill, Kuipers, Hester, Vooij, Dani, Chinyenze, Kundai, Priddy, Frances, Ding, Song, Hanke, Tom, and Pantaleo, Giuseppe
- Published
- 2017
16. Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection.
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Macharia, Gladys N., Yue, Ling, Staller, Ecco, Dilernia, Dario, Wilkins, Daniel, Song, Heeyah, McGowan, Edward, King, Deborah, Fast, Pat, Imami, Nesrina, Price, Matthew A., Sanders, Eduard J., Hunter, Eric, and Gilmour, Jill
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T cells ,HIV infections ,VIRUS diseases ,MOLECULAR cloning ,INFECTION ,B cells - Abstract
HIV-1 transmission is associated with a severe bottleneck in which a limited number of variants from a pool of genetically diverse quasispecies establishes infection. The IAVI protocol C cohort of discordant couples, female sex workers, other heterosexuals and men who have sex with men (MSM) present varying risks of HIV infection, diverse HIV-1 subtypes and represent a unique opportunity to characterize transmitted/founder viruses (TF) where disease outcome is known. To identify the TF, the HIV-1 repertoire of 38 MSM participants' samples was sequenced close to transmission (median 21 days post infection, IQR 18–41) and assessment of multivariant infection done. Patient derived gag genes were cloned into an NL4.3 provirus to generate chimeric viruses which were characterized for replicative capacity (RC). Finally, an evaluation of how the TF virus predicted disease progression and modified the immune response at both acute and chronic HIV-1 infection was done. There was higher prevalence of multivariant infection compared with previously described heterosexual cohorts. A link was identified between multivariant infection and replicative capacity conferred by gag, whereby TF gag tended to be of lower replicative capacity in multivariant infection (p = 0.02) suggesting an overall lowering of fitness requirements during infection with multiple variants. Notwithstanding, multivariant infection was associated with rapid CD4
+ T cell decline and perturbances in the CD4+ T cell and B cell compartments compared to single variant infection, which were reversible upon control of viremia. Strategies aimed at identifying and mitigating multivariant infection could contribute toward improving HIV-1 prognosis and this may involve strategies that tighten the stringency of the transmission bottleneck such as treatment of STI. Furthermore, the sequences and chimeric viruses help with TF based experimental vaccine immunogen design and can be used in functional assays to probe effective immune responses against TF. Author summary: The development of a safe and effective HIV-1 vaccine alongside cure strategies is a major public health concern and requires in-depth knowledge of the HIV-1 populations that establish infection. Here we sequenced the HIV genetic populations present during the acute stage of HIV-1 infection in 38 Men who have sex with men (MSM) and identified the transmitted/founder variant's sequence. We then cloned the gag gene from each patient's transmitted/founder gag sequences in both single and multiple variant infection into a common, lab-adapted virus and measured the replicative capacity it conferred on this virus. Finally, cellular immune responses were compared between single variant and multiple variant infection at 0–3, 6–9 and 24–30 months after infection. We observed a higher frequency of multivariant infection in MSM than has been previously described in heterosexually infected participants, and this was associated with faster decline of CD4+ T cells and perturbances in the CD4+ T cell and the B cell compartment. Moreover, the replicative capacity conferred by gag was lower in multivariant infection, suggesting a less stringent transmission bottleneck that allowed for less fit variants to establish infection. These results suggest that strategies to tighten the stringency of the transmission bottleneck may be of benefit to patients by reducing the likelihood of multivariant transmission and potentially slowing down disease progression. [ABSTRACT FROM AUTHOR]- Published
- 2020
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17. Understanding mobility and sexual risk behaviour among women in fishing communities of Lake Victoria in East Africa: a qualitative study.
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Kwena, Zachary, Nakamanya, Sarah, Nanyonjo, Gertrude, Okello, Elialilia, Fast, Pat, Ssetaala, Ali, Oketch, Bertha, Price, Matt, Kapiga, Saidi, Bukusi, Elizabeth, Seeley, Janet, the LVCHR, Grosskurth, Heiner, Kamali, Anatoli, Kaleebu, Pontiano, Kibengo, Freddie Mukasa, Kidega, William, De Bont, Jan, and LVCHR
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FISHING villages ,HIV prevention ,HIV infections ,WOMEN'S sexual behavior ,WOMEN - Abstract
Background: HIV-prevalence and incidence is high in many fishing communities around Lake Victoria in East Africa. In these settings, mobility among women is high and may contribute to increased risk of HIV infection and poor access to effective prevention and treatment services. Understanding the nature and patterns of this mobility is important for the design of interventions. We conducted an exploratory study to understand the nature and patterns of women's mobility to inform the design of HIV intervention trials in fishing communities of Lake Victoria.Methods: This was a cross-sectional formative qualitative study conducted in six purposively selected fishing communities in Kenya, Tanzania and Uganda. Potential participants were screened for eligibility on age (18+ years) and having stayed in the fishing community for more than 6 months. We collected data using introductory and focus group discussions, and in-depth interviews with key informants. Data focused on: history and patterns of mobility, migration in and out of fishing communities and the relationship between mobility and HIV infection. Since the interviews and discussions were not audio-recorded, detailed notes were taken and written up into full scripts for analysis. We conducted a thematic analysis using constant comparison analysis.Results: Participants reported that women in fishing communities were highly mobile for work-related activities. Overall, we categorized mobility as travels over long and short distances or periods depending on the kind of livelihood activity women were involved in. Participants reported that women often travelled to new places, away from familiar contacts and far from healthcare access. Some women were reported to engage in high risk sexual behaviour and disengaging from HIV care. However, participants reported that women often returned to the fishing communities they considered home, or followed a seasonal pattern of work, which would facilitate contact with service providers.Conclusion: Women exhibited circular and seasonal mobility patterns over varying distances and duration away from their home communities. These mobility patterns may limit women's access to trial/health services and put them at risk of HIV-infection. Interventions should be tailored to take into account mobility patterns of seasonal work observed in this study. [ABSTRACT FROM AUTHOR]- Published
- 2020
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18. Retention of adults from fishing communities in an HIV vaccine preparedness study in Masaka, Uganda
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Bahemuka, Ubaldo, primary, Abaasa, Andrew, additional, Ruzagira, Eugene, additional, Lindan, Christina, additional, Price, Matt A, additional, Kamali, Anatoli, additional, and Fast, Pat, additional
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- 2018
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19. Assessment of Anti–HIV-1 Antibodies in Oral and Nasal Compartments of Volunteers From 3 Different Populations
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Bergin, Philip J., primary, Langat, Robert, additional, Omosa-Manyonyi, Gloria, additional, Farah, Bashir, additional, Ouattara, Gina, additional, Park, Harriet, additional, Coutinho, Helen, additional, Laufer, Dagna, additional, Fast, Pat, additional, Verlinde, Carl, additional, Bizimana, Jean, additional, Umviligihozo, Gisele, additional, Nyombayire, Julien, additional, Ingabire, Rosine, additional, Kuldanek, Kristin, additional, Cox, Josephine, additional, McMorrow, Martin, additional, Fidler, Sarah, additional, Karita, Etienne, additional, Gilmour, Jill, additional, and Anzala, Omu, additional
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- 2016
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20. Early Antibody Lineage Diversification and Independent Limb Maturation Lead to Broad HIV-1 Neutralization Targeting the Env High-Mannose Patch
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MacLeod, Daniel T., primary, Choi, Nancy M., additional, Briney, Bryan, additional, Garces, Fernando, additional, Ver, Lorena S., additional, Landais, Elise, additional, Murrell, Ben, additional, Wrin, Terri, additional, Kilembe, William, additional, Liang, Chi-Hui, additional, Ramos, Alejandra, additional, Bian, Chaoran B., additional, Wickramasinghe, Lalinda, additional, Kong, Leopold, additional, Eren, Kemal, additional, Wu, Chung-Yi, additional, Wong, Chi-Huey, additional, Kosakovsky Pond, Sergei L., additional, Wilson, Ian A., additional, Burton, Dennis R., additional, Poignard, Pascal, additional, Price, Matt A., additional, Gilmour, Jill, additional, Fast, Pat, additional, Kamali, Anatoli, additional, Sanders, Eduard J., additional, Anzala, Omu, additional, Allen, Susan, additional, Hunter, Eric, additional, Karita, Etienne, additional, Lakhi, Shabir, additional, Inambao, Mubiana, additional, Edward, Vinodh, additional, and Bekker, Linda-Gail, additional
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- 2016
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21. Canine distemper virus neutralization activity is low in human serum and it is sensitive to an amino acid substitution in the hemagglutinin protein
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Zhang, Xinsheng, primary, Wallace, Olivia L., additional, Domi, Arban, additional, Wright, Kevin J., additional, Driscoll, Jonathan, additional, Anzala, Omu, additional, Sanders, Eduard J., additional, Kamali, Anatoli, additional, Karita, Etienne, additional, Allen, Susan, additional, Fast, Pat, additional, Gilmour, Jill, additional, Price, Matt A., additional, and Parks, Christopher L., additional
- Published
- 2015
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22. The Immune Space: A Concept and Template for Rationalizing Vaccine Development
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Manrique, Amapola, primary, Adams, Elizabeth, additional, Barouch, Dan H., additional, Fast, Pat, additional, Graham, Barney S., additional, Kim, Jerome H., additional, Kublin, James G., additional, McCluskey, Margaret, additional, Pantaleo, Giuseppe, additional, Robinson, Harriet L., additional, Russell, Nina, additional, Snow, William, additional, and Johnston, Margaret I., additional
- Published
- 2014
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23. Acceptability and Feasibility of Repeated Mucosal Specimen Collection in Clinical Trial Participants in Kenya
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Omosa-Manyonyi, Gloria, primary, Park, Harriet, additional, Mutua, Gaudensia, additional, Farah, Bashir, additional, Bergin, Philip J., additional, Laufer, Dagna, additional, Lehrman, Jennifer, additional, Chinyenze, Kundai, additional, Barin, Burc, additional, Fast, Pat, additional, Gilmour, Jill, additional, and Anzala, Omu, additional
- Published
- 2014
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24. Assessment of Understanding for Informed Consent in HIV Vaccine Trials
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Lindegger, Graham C., primary, Quayle, Michael, additional, Slack, Catherine M., additional, Singh, Sagri, additional, Welsh, Sabrina, additional, and Fast, Pat, additional
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- 2014
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25. African Early Infection Cohort as a Platform for Vaccine Discovery: The IAVI Protocol C Experience
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Gilmour, Jill, primary, Kamali, Anatoli, additional, Karita, Etienne, additional, Kilembe, William, additional, Sanders, Eduard J., additional, Anzala, Omu, additional, Allen, Susan, additional, Edward, Vinodh, additional, Priddy, Fran, additional, Price, Matt A., additional, Macharia, Gladys, additional, Baalwa, Joshua, additional, Crotty, Shane, additional, Denny, Thomas, additional, Landais, Elise, additional, Borrow, Persephone, additional, Tang, Jianming, additional, Busch, Michael, additional, Prince, Jessica, additional, Claiborne, Dan, additional, Poignard, Pascal, additional, Fast, Pat, additional, and Hunter, Eric, additional
- Published
- 2014
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26. Implementation of a Training Program to Standardize Mucosal Sample Collection and Processing at Multiple Laboratories in Eastern Africa
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Omosa-Manyonyi, Gloria, primary, Langat, Robert, additional, Mutisya, Elizabeth, additional, Park, Harriet, additional, Bergin, Philip, additional, Farah, Bashir, additional, Ogutu, Hilda, additional, Ogola, Simon, additional, Ouattara, Gina, additional, Indangasi, Jackton, additional, Ndambuki, Rose, additional, Fast, Pat, additional, Laufer, Dagna, additional, Priddy, Fran, additional, and Anzala, Omu, additional
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- 2014
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27. Recall of Acute Retroviral Symptoms in a Multicentre Cohort Study in Africa
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Sanders, Eduard J., primary, Powers, Kimberley A., additional, Karita, Etienne, additional, Kamali, Anatoli, additional, Kilemba, William, additional, Allen, Susan, additional, Hunter, Eric, additional, Anzala, Omu, additional, Fast, Pat, additional, and Price, Matthew A., additional
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- 2014
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28. Participation of Individuals from Fishing Communities in a Simulated Vaccine Efficacy Trial in Preparation for Future HIV Prevention Work
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Asiki, Gershim, primary, Abaasa, Andrew, additional, Bahemuka, Ubaldo, additional, Mulondo, Jerry, additional, Kibengo, Freddie, additional, Ruzagira, Eugene, additional, Kamali, Anatoli, additional, and Fast, Pat, additional
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- 2014
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29. Use of Virtual Cohorts in Zambia's Couples' Voluntary Counseling and Testing (CVCT) as a Screening Mechanism for Clinical Trials
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Sharkey, Tyronza, primary, Parker, Rachel, additional, Kilembe, William, additional, Inambao, Mubiana, additional, Priddy, Frances, additional, Fast, Pat, additional, Price, Matt, additional, Tichacek, Amanda, additional, Hunter, Eric, additional, and Allen, Susan, additional
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- 2014
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30. Prevalence of HIV, Sexual Transmitted Infections and High Risk Sexual Behaviors among Female Sex Workers in Kigali, Rwanda
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Mukamuyango, Jeannine, primary, Ingabire, Rosine, additional, Karita, Etienne, additional, Nyombayire, Julien, additional, Sinabamenye, Robertine, additional, Ahmed, Nuri, additional, Nduwamungu, Jean Nepo, additional, Radjabari, Sukaina, additional, Oppert, Marydale, additional, Price, Matt, additional, Priddy, Frances, additional, Fast, Pat, additional, Tichacek, Amanda, additional, and Allen, Susan, additional
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- 2014
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31. Detection of Vaccine Induced Mucosal Antibodies in Phase I HIV Preventative Vaccine Trials
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Bergin, Phil, primary, Langat, Robert, additional, Farah, Bashir, additional, Ogola, Simon, additional, Omosa-Manyonyi, Gloria, additional, Mutua, Gaudensia, additional, Outtara, Gina, additional, Park, Harriet, additional, Lehrman, Jennifer, additional, Mwangi, Irene, additional, Coutinho, Helen, additional, Chetty, Paramesh, additional, McMorrow, Martin, additional, Cox, Josephine, additional, Fast, Pat, additional, Laufer, Dagna, additional, Gilmour, Jill, additional, and Anzala, Omu, additional
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- 2014
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32. Overweight BMI and Alcohol Use Are Associated with Immune Responses in Phase I HIV Vaccine Trials
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Bayingana, Roger, primary, Mutua, Gaudensia, additional, Mpendo, Juliet, additional, Kilembe, William, additional, Omosa-Manyonyi, Gloria, additional, Ruzagirwa, Eugene, additional, Page-Shipp, Liesl, additional, Gray, Glenda, additional, Bekker, Linda-Gail, additional, Baden, Lindsey, additional, Hayes, Peter, additional, Dally, Len, additional, Schmidt, Claudia, additional, Laufer, Dagna, additional, Priddy, Frances, additional, Fast, Pat, additional, Gilmour, Jill, additional, and Cox, Josephine, additional
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- 2014
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33. Participation in Clinical Research Could Modify Background Risk for Trial Outcome Measures
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Abaasa, Andrew M., primary, Asiki, Gershim, additional, Levin, Jonathan, additional, Bahemuka, Ubaldo, additional, Ruzagira, Eugene, additional, Kibengo, Freddie M., additional, Mulondo, Jerry, additional, Ndibazza, Juliet, additional, Price, Matthew A., additional, Fast, Pat, additional, and Kamali, Anatoli, additional
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- 2014
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34. Developing standards of care for HIV prevention research in developing countries – a case study of 10 research centers in Eastern and Southern Africa
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Ngongo, Prince Bahati, primary, Priddy, Frances, additional, Park, Harriet, additional, Becker, Julie, additional, Bender, Bonnie, additional, Fast, Pat, additional, Anzala, Omu, additional, Mutua, Gaudensia, additional, Ruzagira, Eugene, additional, Kamali, Anatoli, additional, Karita, Etienne, additional, Mugo, Peter, additional, Chomba, Elwyn, additional, Bekker, Linda-Gail, additional, Roux, Surita, additional, Nanvubya, Annet, additional, and Mebrahtu, Tsedal, additional
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- 2012
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35. Ensuring quality of services in HIV prevention research settings: findings from a multi-center quality improvement pilot in East Africa
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Ngongo Bahati, Prince, primary, Kidega, William, additional, Ogutu, Hilda, additional, Odada, Jane, additional, Bender, Bonnie, additional, Fast, Pat, additional, Becker, Julie, additional, and Price, Matt, additional
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- 2009
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36. CLSI-Derived Hematology and Biochemistry Reference Intervals for Healthy Adults in Eastern and Southern Africa
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Karita, Etienne, primary, Ketter, Nzeera, additional, Price, Matt A., additional, Kayitenkore, Kayitesi, additional, Kaleebu, Pontiano, additional, Nanvubya, Annet, additional, Anzala, Omu, additional, Jaoko, Walter, additional, Mutua, Gaudensia, additional, Ruzagira, Eugene, additional, Mulenga, Joseph, additional, Sanders, Eduard J., additional, Mwangome, Mary, additional, Allen, Susan, additional, Bwanika, Agnes, additional, Bahemuka, Ubaldo, additional, Awuondo, Ken, additional, Omosa, Gloria, additional, Farah, Bashir, additional, Amornkul, Pauli, additional, Birungi, Josephine, additional, Yates, Sarah, additional, Stoll-Johnson, Lisa, additional, Gilmour, Jill, additional, Stevens, Gwynn, additional, Shutes, Erin, additional, Manigart, Olivier, additional, Hughes, Peter, additional, Dally, Len, additional, Scott, Janet, additional, Stevens, Wendy, additional, Fast, Pat, additional, and Kamali, Anatoli, additional
- Published
- 2009
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37. Baseline Morbidity in 2,990 Adult African Volunteers Recruited to Characterize Laboratory Reference Intervals for Future HIV Vaccine Clinical Trials
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Stevens, Wendy, primary, Kamali, Anatoli, additional, Karita, Etienne, additional, Anzala, Omu, additional, Sanders, Eduard J., additional, Jaoko, Walter, additional, Kaleebu, Pontiano, additional, Mulenga, Joseph, additional, Dally, Len, additional, Fast, Pat, additional, Gilmour, Jill, additional, Farah, Bashir, additional, Birungi, Josephine, additional, Hughes, Peter, additional, Manigart, Olivier, additional, Stevens, Gwynn, additional, Yates, Sarah, additional, Thomson, Helen, additional, von Lieven, Andrea, additional, Krebs, Marietta, additional, Price, Matt A., additional, Stoll-Johnson, Lisa, additional, and Ketter, Nzeera, additional
- Published
- 2008
- Full Text
- View/download PDF
38. High Transmitter CD4+ T-Cell Count Shortly after the Time of Transmission in a Study of African Serodiscordant Couples.
- Author
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Karita, Etienne, Price, Matt A, Lakhi, Shabir, Kilembe, William, Kamali, Anatoli, Ruzagira, Eugene, Hunter, Eric, Farmer, Paul, Allen, Susan, Stevens, Gwynn, Chetty, Paramesh, Welsh, Sabrina, Yang, Annie, Gilmour, Jill, Fast, Pat, and null, null
- Subjects
HIV infection transmission ,CD4 antigen ,T cells ,AFRICANS ,LONGITUDINAL method ,DISEASES - Abstract
Background: 2013 WHO guidelines recommend starting ART at CD4+ T-cell counts ≤500 cells/μL. We present the T-cell counts from adult Africans with HIV shortly following transmission to their sexual partners. Methods: HIV-discordant couples in Zambia, Uganda and Rwanda were followed prospectively and received couples counseling and condoms. HIV uninfected partners were tested for HIV at least quarterly and HIV-infected partners received HIV care and referral for ART per national guidelines. Upon diagnosis of incident HIV infection in the previously HIV-uninfected partner, a blood sample was collected from both partners to measure CD4+ T-cells and perform viral linkage. The estimated date of infection (EDI) of the incident case was calculated based on testing history. EDI was unknown for suspected transmitting partners. Results: From 2006–2011, 4,705 HIV-discordant couples were enrolled in this cohort, and 443 cases of incident HIV infection were documented. Virus linkage analysis was performed in 374 transmission pairs, and 273 (73%) transmissions were linked genetically. CD4 counts in the transmitting partner were measured a median of 56 days after EDI (mean:90.5, min:10, max:396). The median CD4 count was 339 cells/μl (mean:386.4, min:15, max:1,434), and the proportion of partners with a CD4+ T-cell count above 500/μl was 25% (95% CI:21, 31). Conclusions: In our cohort of discordant couples, 73% of HIV transmissions occurred within the relationship, and the transmitter CD4+ T cell count shortly after the transmission event was frequently higher than the WHO 2013 ART-initiation guidelines. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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- View/download PDF
39. Induction of Multifunctional Human Immunodeficiency Virus Type 1 (HIV-1)-Specific T Cells Capable of Proliferation in Healthy Subjects by Using a Prime-Boost Regimen of DNA- and Modified Vaccinia Virus Ankara-Vectored Vaccines Expressing HIV-1 Gag Coupled to CD8+T-Cell Epitopes
- Author
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Goonetilleke, Nilu, primary, Moore, Stephen, additional, Dally, Len, additional, Winstone, Nicola, additional, Cebere, Inese, additional, Mahmoud, Abdul, additional, Pinheiro, Susana, additional, Gillespie, Geraldine, additional, Brown, Denise, additional, Loach, Vanessa, additional, Roberts, Joanna, additional, Guimaraes-Walker, Ana, additional, Hayes, Peter, additional, Loughran, Kelley, additional, Smith, Carole, additional, De Bont, Jan, additional, Verlinde, Carl, additional, Vooijs, Danii, additional, Schmidt, Claudia, additional, Boaz, Mark, additional, Gilmour, Jill, additional, Fast, Pat, additional, Dorrell, Lucy, additional, Hanke, Tomas, additional, and McMichael, Andrew J., additional
- Published
- 2006
- Full Text
- View/download PDF
40. Immunization with Cocktail of HIV-Derived Peptides in Montanide ISA-51 Is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity.
- Author
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Graham, Barney S., McElrath, M. Juliana, Keefer, Michael C., Rybczyk, Kyle, Berger, David, Weinhold, Kent J., Ottinger, Janet, Ferarri, Guido, Montefiori, David C., Stablein, Don, Smith, Carol, Ginsberg, Richard, Eldridge, John, Duerr, Ann, Fast, Pat, and Haynes, Barton F.
- Subjects
PEPTIDES ,HIV antibodies ,VACCINES ,PLACEBOS ,T cells ,B cells ,ABSCESSES ,IMMUNE response ,IMMUNOLOGICAL adjuvants ,IMMUNIZATION ,BLIND experiment - Abstract
Background: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in incomplete Freund's adjuvant (IFA). Methods: Low-risk, healthy adult subjects were enrolled in a randomized, placebo-controlled dose-escalation study, and selected using criteria specifying that 50% in each study group would be HLA-B7+. Immunizations were scheduled at 0, 1, and 6 months using a total peptide dose of 1 or 4 mg. Adaptive immune responses in16 vaccine recipients and two placebo recipients after the 2nd immunization were evaluated using neutralization assays of sera, as well as ELISpot and ICS assays of cryopreserved PBMCs to assess CD4 and CD8 T-cell responses. In addition,
51 Cr release assays were performed on fresh PBMCs following 14-day stimulation with individual vaccine peptide antigens. Results: 24 subjects were enrolled; 18 completed 2 injections. The study was prematurely terminated because 4 vaccinees developed prolonged pain and sterile abscess formation at the injection site-2 after dose 1, and 2 after dose 2. Two other subjects experienced severe systemic reactions consisting of headache, chills, nausea, and myalgia. Both reactions occurred after the second 4 mg dose. The immunogenicity assessments showed that 6/8 vaccinees at each dose level had detectable MN-specific neutralizing (NT) activity, and 2/7 HLA-B7+ vaccinees had classical CD8 CTL activity detected. However, using both ELISpot and ICS, 8/16 vaccinees (5/7 HLA-B7+) and 0/2 controls had detectable vaccine-specific CD8 T-cell responses. Subjects with moderate or severe systemic or local reactions tended to have more frequent T cell responses and higher antibody responses than those with mild or no reactions. Conclusions: The severity of local responses related to the formulation of these four peptides in IFA is clinically unacceptable for continued development. Both HIV-specific antibody and T cell responses were induced and the magnitude of response correlated with the severity of local and systemic reactions. If potent adjuvants are necessary for subunit vaccines to induce broad and durable immune responses, careful, incremental clinical evaluation is warranted to minimize the risk of adverse events. [ABSTRACT FROM AUTHOR]- Published
- 2010
- Full Text
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41. Ensuring quality of services in HIV prevention research settings: findings from a multi-center quality improvement pilot in East Africa.
- Author
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Ngongo Bahati, Prince, Kidega, William, Ogutu, Hilda, Odada, Jane, Bender, Bonnie, Fast, Pat, Becker, Julie, and Price, Matt
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MEDICAL care ,HIV ,RESEARCH institutes ,ELECTRONIC spreadsheets ,PHARMACISTS ,HIV prevention ,VOLUNTEERS - Abstract
Quality improvement (QI) has been widely implemented in health services but has not been widely applied in HIV prevention research. Most prevention research centers have commonly employed traditional approaches (e.g., checklists) to quality control that document what has been done but not the quality of what has been done. Unlike other health settings, prevention research settings have unique characteristics and ethical requirements that require the development or adaptation of specific quality indicators. A QI model for health services was adapted for use in prevention research settings and was piloted between August 2006 and July 2007 at three research centers in East Africa. Four hundred and twenty-six volunteers exit interviews were administered in two cycles. Quantitative and qualitative data were analyzed using Excel worksheets. QI meeting reports and QI plans were used to complement data from exit interviews. On average, 52% of total enrolled volunteers participated in the exit interview. The designed QI plans successfully helped reduce volunteers' reported waiting time to see counselors (p<0.001) and pharmacists (p<0.001). It also increased the percentage of interviewed volunteers who reported being counseled on family planning at clinical trials (from 66 to 93%; p=0.02) at follow-up visits, and who were refreshed on informed consent at follow-up visits (from 90 to 96%; p=0.009). The percentage of interviewed volunteers that expressed satisfaction with services received from counselors increased (from 87 to 94%; p=0.009) while the percentage of volunteer satisfied with services from trial physicians remained constant (93%). The majority of volunteers interviewed reported satisfaction with other major components of research such as confidentiality, understanding of trial objectives, benefits and risks of participation, and risk reduction counseling. However, satisfaction with services from community outreach workers and other staff at research centers dropped over the course of the study (from 88% in Cycle 1 to 74% in Cycle 3; p= < 0.001). Increased commitment to QI is crucial in ensuring quality of services and ethical conduct of HIV prevention research centers. [ABSTRACT FROM AUTHOR]
- Published
- 2010
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42. Overweight BMI and Alcohol Use Are Associated with Immune Responses in Phase I HIV Vaccine Trials.
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Mutua, Gaudensia, Mpendo, Juliet, Kilembe, William, Omosa-Manyonyi, Gloria, Ruzagirwa, Eugene, Page-Shipp, Liesl, Gray, Glenda, Bekker, Linda-Gail, Baden, Lindsey, Hayes, Peter, Dally, Len, Schmidt, Claudia, Laufer, Dagna, Priddy, Frances, Fast, Pat, Gilmour, Jill, and Cox, Josephine
- Abstract
An abstract of the article "Overweight BMI and Alcohol Use Are Associated with Immune Responses in Phase I HIV Vaccine Trials" by Gaudensia Mutua, Juliet Mpendo and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
43. Participation in Clinical Research Could Modify Background Risk for Trial Outcome Measures.
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Asiki, Gershim, Levin, Jonathan, Bahemuka, Ubaldo, Ruzagira, Eugene, Kibengo, Freddie M., Mulondo, Jerry, Ndibazza, Juliet, Price, Matthew A., Fast, Pat, and Kamali, Anatoli
- Abstract
An abstract of the article "Participation in Clinical Research Could Modify Background Risk for Trial Outcome Measures" by Andrew M. Abaasa, Gershim Asiki, Jonathan Levin, Ubaldo Bahemuka and colleagues is presented.
- Published
- 2014
- Full Text
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44. Implementation of a Training Program to Standardize Mucosal Sample Collection and Processing at Multiple Laboratories in Eastern Africa.
- Author
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Langat, Robert, Mutisya, Elizabeth, Park, Harriet, Bergin, Philip, Farah, Bashir, Ogutu, Hilda, Ogola, Simon, Ouattara, Gina, Indangasi, Jackton, Ndambuki, Rose, Fast, Pat, Laufer, Dagna, Priddy, Fran, and Anzala, Omu
- Abstract
An abstract of the article "Implementation of a Training Program to Standardize Mucosal Sample Collection and Processing at Multiple Laboratories in Eastern Africa" by Robert Langat, Elizabeth Mutisya, Harriet Park and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
45. Use of Virtual Cohorts in Zambia's Couples' Voluntary Counseling and Testing (CVCT) as a Screening Mechanism for Clinical Trials.
- Author
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Parker, Rachel, Kilembe, William, Inambao, Mubiana, Priddy, Frances, Fast, Pat, Price, Matt, Tichacek, Amanda, Hunter, Eric, and Allen, Susan
- Abstract
An abstract of the article "Use of Virtual Cohorts in Zambia's Couples' Voluntary Counseling and Testing (CVCT) as a Screening Mechanism for Clinical Trials" by Tyronza Sharkey, Rachel Parker, William Kilembe and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
46. Detection of Vaccine Induced Mucosal Antibodies in Phase I HIV Preventative Vaccine Trials.
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Langat, Robert, Farah, Bashir, Ogola, Simon, Omosa-Manyonyi, Gloria, Mutua, Gaudensia, Outtara, Gina, Park, Harriet, Lehrman, Jennifer, Mwangi, Irene, Coutinho, Helen, Chetty, Paramesh, McMorrow, Martin, Cox, Josephine, Fast, Pat, Laufer, Dagna, Gilmour, Jill, and Anzala, Omu
- Abstract
An abstract of the article "Detection of Vaccine Induced Mucosal Antibodies in Phase I HIV Preventative Vaccine Trials" by Phil Bergin and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
47. Assessment of Understanding for Informed Consent in HIV Vaccine Trials.
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Quayle, Michael, Slack, Catherine M., Singh, Sagri, Welsh, Sabrina, and Fast, Pat
- Abstract
An abstract of the article "Assessment of Understanding for Informed Consent in HIV Vaccine Trials" by Graham C. Lindegger and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
48. Prevalence of HIV, Sexual Transmitted Infections and High Risk Sexual Behaviors among Female Sex Workers in Kigali, Rwanda.
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Ingabire, Rosine, Karita, Etienne, Nyombayire, Julien, Sinabamenye, Robertine, Ahmed, Nuri, Nduwamungu, Jean Nepo, Radjabari, Sukaina, Oppert, Marydale, Price, Matt, Priddy, Frances, Fast, Pat, Tichacek, Amanda, and Allen, Susan
- Abstract
An abstract of the article "Prevalence of HIV, Sexual Transmitted Infections and High Risk Sexual Behaviors among Female Sex Workers in Kigali, Rwanda" by Jeannine Mukamuyango and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
49. Recall of Acute Retroviral Symptoms in a Multicentre Cohort Study in Africa.
- Author
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Powers, Kimberley A., Karita, Etienne, Kamali, Anatoli, Kilemba, William, Allen, Susan, Hunter, Eric, Anzala, Omu, Fast, Pat, and Price, Matthew A.
- Abstract
An abstract of the article "Recall of Acute Retroviral Symptoms in a Multicentre Cohort Study in Africa" by Eduard J. Sanders, Kimberley A. Powers, Etienne Karita and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
50. Participation of Individuals from Fishing Communities in a Simulated Vaccine Efficacy Trial in Preparation for Future HIV Prevention Work.
- Author
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Abaasa, Andrew, Bahemuka, Ubaldo, Mulondo, Jerry, Kibengo, Freddie, Ruzagira, Eugene, Kamali, Anatoli, and Fast, Pat
- Abstract
An abstract of the article "Participation of Individuals from Fishing Communities in a Simulated Vaccine Efficacy Trial in Preparation for Future HIV Prevention Work" by Gershim Asiki, Andrew Abaasa, Ubaldo Bahemuka and colleagues is presented.
- Published
- 2014
- Full Text
- View/download PDF
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