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20 results on '"Feng, Li-Jin"'

6. Risk of severe hematologic toxicities in cancer patients treated with PARP inhibitors: a meta-analysis of randomized controlled trials

Author

Zhou,Jian Xin, Feng,Li Jin, Zhang,Xi, Zhou,Jian Xin, Feng,Li Jin, and Zhang,Xi

Abstract

Jian xin Zhou,1,* Li jin Feng,2,* Xi Zhang3 1Department of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 2Department of Pathology, Shanghai Tenth People’s Hospital, Tongji University, School of Medicine, Shanghai, 3Department of Radiation Oncology, Affiliated Hospital of Hebei University, Baoding, China *These authors contributed equally to this work Purpose: Hematologic toxicities, including neutropenia, thrombocytopenia, and anemia, are major adverse effects of PARP inhibitors (PARPis), but the incidence rate and overall risk has not been systematically studied. Therefore, we conducted a meta-analysis of published clinical trials to investigate the incidence and relative risks (RRs) of severe (high-grade) hematologic events in cancer patients treated with PARPis.Methods: PubMed, Embase, and oncology conference proceedings were searched for relevant studies. Eligible studies were Phase II and III randomized controlled trials (RCTs) of PARPis in cancer patients with adequate safety data on hematologic toxicities. The summary incidence, RRs, and 95% confidence intervals (CIs) were calculated.Results: A total of 2,479 patients from 12 RCTs revealed that the incidence of PARPi-associated severe hematologic toxicities was, respectively: neutropenia: 32.9% (95% CI, 20.5%–48.3%); thrombocytopenia: 15.9% (95% CI, 9.5%–25.4%), and anemia: 9.1% (95% CI, 5.1%–15.7%). Olaparib was associated with an increased risk of severe neutropenia. Veliparib was associated with an increased risk of severe neutropenia and thrombocytopenia. Niraparib was associated with an increased risk of severe thrombocytopenia, anemia, and neutropenia. When stratified by combination therapy, significantly increased risk of hematologic toxicities was observed for patients treated with PARPis monotherapy and PARPis combined with single-agent chemotherapy.Conclusion: Treatment with PARPis olaparib, veliparib, and nirapar

Published
2017

7. Synchrotron radiation (SR) diffraction enhanced imaging (DEI) of chronic glomerulonephritis (CGN) mode

Author

Xia Chen-Chen, Peng Yi-feng, Zhang Kai, Yuan Qing-Xi, Wu A-Shan, Feng Li-Jin, Arun Kumar Yadav, Tang Guangyu, Xu Xu-Dong, and Zhu Pei-Ping

Subjects
Diffraction, Pathology, medicine.medical_specialty, Slope position, Synchrotron radiation, Computed tomography, Kidney, Kidney Function Tests, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, User-Computer Interface, 0302 clinical medicine, Glomerulonephritis, Imaging, Three-Dimensional, Chronic glomerulonephritis, Medicine, Animals, Radiology, Nuclear Medicine and imaging, Electrical and Electronic Engineering, Instrumentation, Radiation, medicine.diagnostic_test, business.industry, Condensed Matter Physics, Clinical Practice, 030220 oncology & carcinogenesis, Rabbit model, Rabbits, business, Nuclear medicine, Tomography, X-Ray Computed, Beam energy, Synchrotrons
Abstract

OBJECTIVE The aim of this study is to investigate microstructural changes in chronic glomerulonephritis (CGN) rabbit model under diffraction enhanced imaging (DEI) technology of synchrotron radiation (SR). MATERIALS AND METHODS The chronic glomerulonephritis (CGN) models were obtained within two months after 5 New Zealand white rabbits were treated with doxorubicin hydrochloride. Blood exams, urine tests and kidney histological studies were carried out after the 5 rabbits were humanely sacrificed by hyperanesthesia. The kidney tissues were fixed in 4% formalin for one week before DEI experiment, with another 5 normal rabbits used as the control group. The experiment was performed at Beijing Synchrotron Radiation Facility (BSRF) with a 4W1A beam line (beam energy was 14keV). On routine scanning process, the rocking curve was detected, and slope position on the curve was selected to make a 360° spatial CT scan; DEI reconstruction software was used to generate a 3-dimensional image, from which the difference in grey value between the chronic glomerulonephritis (CGN) group and the control group was measured and analyzed using MATLAB and SPSS. RESULT Without radio-contrast, DEI provided clear visibility of the microstructures including artery, vein, straight collecting ducts, papillary tubules, glomeruli in both the chronic glomerulonephritis (CGN) group and the control group, with a spatial resolution as low as 10μm. MATLAB grey value extraction and SPSS analysis showed that cortex of CGN group (91 to 112) lost more gray value compared to the control group (121 to 141), T tests P < 0.05. Equivalant cortical ROI (data points 450×80) quantitative analysis showed that gross grey value of CGN group (ranking from 55 to 160) was smaller than the control group (ranking from 75 to 175). DEI images correlated well with pathologic images. Morphological changes in the microstructure of contstartabstractCGN kidney was revealed, due to the advantage of phase-contrast imaging (PCI) mechanism, and the diagnostic value of CGN by synchrotron radiation (SR) phase-contrast imaging (PCI) technology was evaluated. CONCLUSION Synchrotron radiation (SR) diffraction enhanced imaging (DEI) experiment makes non-contrast CGN diagnosis possible in the rabbit model studied. With improvement of laboratory equipment and image analyzer in clinical practice, diffraction enhanced imaging (DEI) could fundamentally become a new diagnostic method for CGN.

Published
2016

9. [Diversity of antagonistic bacteria isolated from rhizosphere of several cash crops]

Author

Ying-Ying, Xu, Bing-Hai, Du, Liang-Tong, Yao, Feng-Li, Jin, Cui-Cui, Wang, Xuan, Wang, and Yan-Qin, Ding

Subjects
Gossypium, Bacteria, Brevibacillus, Solanum lycopersicum, Pseudomonas, Antibiosis, Rhizosphere, Tobacco, Bacillus, Biodiversity, Paenibacillus, Soil Microbiology
Abstract

By adopting antimicrobial spectrum test, BOXAIR-PCR, physiological and biochemical, and 16S rDNA sequencing analysis, this paper analyzed the diversity of 55 antagonistic bacterial strains isolated from the rhizosphere of 10 cash crops. There was a high diversity of the antagonism of the strains. Based on BOXAIR-PCR, all the strains were clustered into 7 groups at the similarity level of 72.1%, and divided into 25 groups at the similarity level of 85.0%. All the strains belonged to Bacillus, Paenibacillus, Brevibacillus, Pseudomonas and Alcaligenes, respectively. The antagonistic bacteria isolated from the rhizosphere had high genetic diversity and high diversity in antagonistic activity.

Published
2012

18. Hydrothermal Synthesis and Electrochemical Performance of WO3 Nanoparticles

Author

Feng, Li Jin, Ma, Rong, Li, Xiu Hua, and Song, Xu Chun

Abstract

In the present paper, the WO3 nanoparticles were fabricated via a hydrothermal treatment. The products are characterized in detail by multiform techniques: transmission electron microscopy, X-ray diffraction. The results show that products are WO3 nanoparticles with diameter of about 100-150 nm. Electrochemistry properties of the prepared WO3 nanoparticles was characterized by cyclic voltammetry. Cyclic voltammetry results indicate that WO3 nanoparticles exhibits a remarkable electrochemical activity for hydrogen intercalation. The reason for electrochemical activity of WO3 nanoparticles is attributed to the formation of HxWO3 by hydrogen intercalation/de-intercalation into/out of the tungsten oxide.

Published
2013
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19. Electrocatalytic Property for H2O2 Reduction of β-Ni(OH)2 Nanosheets

Author

Feng, Li Jin, Wang, Xia, Yang, Zhi Ai, and Song, Xu Chun

Abstract

The β-Ni(OH)2 nanosheets are fabricated by a hydrothermal method. The products are characterized in detail by multiform techniques: X-ray diffraction(XRD), energy-dispersive X-ray analysis(EDS), scanning electron microscopy(SEM), and transmission electron microscopy(TEM). The results show that the obtained products are nanosheets with diameters of 100-200 nm, and thickness ranging from 10nm to 15 nm . The prepared β-Ni(OH)2 nanosheets are used as electrode materials to study the electrocatalytic reduction of hydrogen peroxide (H2O2) in 0.5 M NaOH solution.

Published
2012
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20. Hydrothermal Synthesis and Electrocatalytic Property for H2O2 Reduction of Co3O4 Nanocubes

Author

Yang, Zhi Ai, Feng, Li Jin, Wang, Xia, Ma, Rong, Sun, Jian Ping, and Song, Xu Chun

Abstract

Subscript textThe Co3O4 nanocubes were synthesized by hydrothermal process. The products are characterized in detail by multiform techniques: scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and energy-dispersive X-ray analysis. The results show that the products are uniform nanocubes with an average crystallite size about 20-40 nm. Electrocatalytic property of the prepared Co3O4 nanocubes was characterized by linear sweep voltammetry. LSV results indicate that Co3O4 nanocubes exhibit a remarkable electrocatalytic activity for the H2O2 reduction.

Published
2011
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