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1. Risk of prostate cancer in the proximity of industrial installations: A multicase-control study in Spain (MCC-Spain)

Author

García-Pérez, Javier, Fernández de Larrea-Baz, Nerea, Lope, Virginia, Domínguez-Castillo, Alejandro, Espinosa, Ana, Dierssen-Sotos, Trinidad, Contreras-Llanes, Manuel, Sierra, María Ángeles, Castaño-Vinyals, Gemma, Tardón, Adonina, Jiménez-Moleón, José J., Molina-Barceló, Ana, Aragonés, Nuria, Kogevinas, Manolis, Pollán, Marina, and Pérez-Gómez, Beatriz

Published
2024
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3. Toenail zinc and risk of prostate cancer in the MCC-Spain case-control study

Author

Gutiérrez-González, Enrique, Pastor-Barriuso, Roberto, Castelló, Adela, Castaño-Vinyals, Gemma, Fernández de Larrea-Baz, Nerea, Dierssen-Sotos, Trinidad, Jiménez-Moleón, José Juan, Molina-Barceló, Ana, Fernández-Tardón, Guillermo, Zumel-Marne, Ángela, Moreno, Víctor, Gómez-Ariza, José Luis, Sierra, M. Ángeles, García-Barrera, Tamara, Espinosa, Ana, Plans-Beriso, Elena, Gómez-Acebo, Inés, Aragonés, Nuria, Kogevinas, Manolis, Pollán, Marina, and Pérez-Gómez, Beatriz

Published
2024
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4. Type does matter. Use VIRGIN olive oil as your preferred fat to reduce your risk of breast cancer: case-control EpiGEICAM study

Author

Donat-Vargas, Carolina, Guerrero-Zotano, Ángel, Lope, Virginia, Bermejo, Begoña, Casas, Ana, Baena-Cañada, José Manuel, Antolín, Silvia, Sánchez-Rovira, Pedro, Antón, Antonio, Garcia-Saénz, José Ángel, Ramos, Manuel, Muñoz, Montserrat, de Juan, Ana, Jara Sánchez, Carlos, Chacón, José Ignacio, Gil-Gil, Miguel, Andrés Conejero, Raquel, Llombart, Antonio, Bezares, Susana, Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Martín, Miguel, and Pollán, Marina

Published
2022
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5. Trajectories of alcohol consumption during life and the risk of developing breast cancer

Author

Donat-Vargas, Carolina, Guerrero-Zotano, Ángel, Casas, Ana, Baena-Cañada, José Manuel, Lope, Virginia, Antolín, Silvia, Garcia-Saénz, José Ángel, Bermejo, Begoña, Muñoz, Montserrat, Ramos, Manuel, de Juan, Ana, Jara Sánchez, Carlos, Sánchez-Rovira, Pedro, Antón, Antonio, Brunet, Joan, Gavilá, Joaquín, Salvador, Javier, Arriola Arellano, Esperanza, Bezares, Susana, Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Martín, Miguel, and Pollán, Marina

Published
2021
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6. Residential proximity to industrial pollution sources and colorectal cancer risk: A multicase-control study (MCC-Spain)

Author

García-Pérez, Javier, Fernández de Larrea-Baz, Nerea, Lope, Virginia, Molina, Antonio J., O'Callaghan-Gordo, Cristina, Alonso, María Henar, Rodríguez-Suárez, Marta María, Mirón-Pozo, Benito, Alguacil, Juan, Gómez-Acebo, Inés, Ascunce, Nieves, Vanaclocha-Espi, Mercedes, Amiano, Pilar, Chirlaque, María Dolores, Simó, Vicente, Jiménez-Moleón, José J., Tardón, Adonina, Moreno, Víctor, Castaño-Vinyals, Gemma, Martín, Vicente, Aragonés, Nuria, Pérez-Gómez, Beatriz, Kogevinas, Manolis, and Pollán, Marina

Published
2020
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7. Biological and prognostic differences between symptomatic colorectal carcinomas and those detected by screening

Author

Quintana Lopez, José María, Mañas, Marisa Baré, Bautista, Maximino Redondo, Pérez de la Blanca, Eduardo Briones, Fernández de Larrea Baz, Nerea, Eizaguirre, Cristina Sarasqueta, Martínez, Antonio Escobar, Ruiz, Francisco Rivas, Morales-Suárez-Varela, María M., Blasco Amaro, Juan Antonio, Gonzalez, Isabel del Cura, Madariaga, Inmaculada Arostegui, González, Amaia Bilbao, Hernandez, Nerea González, García-Gutiérrez, Susana, Guerrero, Iratxe Lafuente, Larracoechea, Urko Aguirre, Calzada, Miren Orive, Corral, Josune Martin, Anton-Ladislao, Ane, Torà, Nuria, Pont, Marina, Martínez del Prado, María Purificación, Totorikaguena, Alberto Loizate, Estevez, Ignacio Zabalza, Alustiza, José Errasti, Gimeno García, Antonio Z., Aramburu, Santiago Lázaro, Serrano, Mercè Comas, Enríquez Navascues, José María, Galan, Carlos Placer, Perales, Amaia, Valmaña, Iñaki Urkidi, Erro Azkárate, José María, Lizarribar, Enrique Cormenzana, Muñoa, Adelaida Lacasta, Pibernat, Pep Piera, Cuevas, Elena Campano, Sotelo Gómez, Ana Isabel, Abril, Segundo Gómez, Medina-Cano, F., Alcaide, Julia, Del Rey-Moreno, Arturo, Alcántara, Manuel Jesús, Campo, Rafael, Casalots, Alex, Pericay, Carles, Gil, María José, Pera, Miquel, Collera, Pablo, Espinàs, Josep Alfons, Martínez, Mercedes, Espallargues, Mireia, Almazán, Caridad, Lindenbaum, Paula Dujovne, Fernández-Cebrián, José María, Fernández, Rocío Anula, Mayol Martínez, Julio Ángel, Cid, Ramón Cantero, Labajo, Héctor Guadalajara, Garceau, María Heras, Olmo, Damián García, Montalvo, Mariel Morey, Mar, Javier, Téllez, Teresa, Abitei, Cristina, Padilla-Ruiz, María del Carmen, Rivas-Ruiz, Francisco, Fúnez, Rafael, Pereda, Teresa, Rodrigo, Isabel, Baré, María Luisa, Morales Suárez-Varela, María Manuela, Zabalza, Iñaki, Sánchez del Charco, Matilde, Borrero Martín, Juan José, García del Moral, Raimundo, Escobar, Antonio, Quintana, José María, Aguirre, Urko, and Redondo, Maximino

Published
2019
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8. Cross-sectional and longitudinal associations of adherence to WCRF/AICR cancer prevention recommendations with health-related quality of life in breast cancer survivors. Health-EpiGEICAM study

Author

Lope, Virginia, Guerrero-Zotano, Ángel, Fernández de Larrea-Baz, Nerea, Antolín, Silvia, Benavent Viñuales, Marta, Bermejo, Begoña, Ruiz-Moreno, Emma, Baena-Cañada, José Manuel, París, Lorena, Antón, Antonio, Chacón, José Ignacio, Muñoz, Montserrat, García-Sáenz, José Angel, Olier, Clara, Sánchez Rovira, Pedro, Arcusa Lanza, Angels, González, Sonia, Brunet, Joan, Oltra, Amparo, Bezares, Susana, Rosell, Libertad, Pérez-Gómez, Beatriz, Pastor-Barriuso, Roberto, Martín, Miguel, and Pollán, Marina

Published
2024
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9. Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

Author

Palomar‐Cros, Anna, primary, Straif, Kurt, additional, Romaguera, Dora, additional, Aragonés, Nuria, additional, Castaño‐Vinyals, Gemma, additional, Martin, Vicente, additional, Moreno, Victor, additional, Gómez‐Acebo, Inés, additional, Guevara, Marcela, additional, Aizpurua, Amaia, additional, Molina‐Barceló, Ana, additional, Jiménez‐Moleón, José‐Juan, additional, Tardón, Adonina, additional, Contreras‐Llanes, Manuel, additional, Marcos‐Gragera, Rafael, additional, Huerta, José Mª, additional, Pérez‐Gómez, Beatriz, additional, Espinosa, Ana, additional, Hernández‐Segura, Natalia, additional, Obón‐Santacana, Mireia, additional, Alonso‐Molero, Jessica, additional, Burgui, Rosana, additional, Amiano, Pilar, additional, Pinto‐Carbó, Marina, additional, Olmedo‐Requena, Rocio, additional, Fernández‐Tardón, Guillermo, additional, Santos‐Sánchez, Vanessa, additional, Fernández de Larrea‐Baz, Nerea, additional, Fernández‐Villa, Tania, additional, Casabonne, Delphine, additional, Dierssen‐Sotos, Trinidad, additional, Ardanaz, Eva, additional, Dorronsoro, Ane, additional, Pollán, Marina, additional, Kogevinas, Manolis, additional, and Lassale, Camille, additional

Published
2023
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10. Mammographic density in the environs of multiple industrial sources

Author

Jiménez, Tamara, primary, Pollán, Marina, additional, Domínguez-Castillo, Alejandro, additional, Lucas, Pilar, additional, Sierra, María Ángeles, additional, Castelló, Adela, additional, Fernández de Larrea-Baz, Nerea, additional, Lora-Pablos, David, additional, Salas-Trejo, Dolores, additional, Llobet, Rafael, additional, Martínez, Inmaculada, additional, Pino, Marina Nieves, additional, Martínez-Cortés, Mercedes, additional, Pérez-Gómez, Beatriz, additional, Lope, Virgina, additional, and García-Pérez, Javier, additional

Published
2023
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11. Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study

Author

Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Michel, Angelika, Romero, Beatriz, Lope, Virginia, Pawlita, Michael, Fernández-Villa, Tania, Moreno, Victor, Martín, Vicente, Willhauck-Fleckenstein, Martina, López-Abente, Gonzalo, Castilla, Jesús, Fernández-Tardón, Guillermo, Dierssen-Sotos, Trinidad, Santibáñez, Miguel, Peiró, Rosana, Jiménez-Moleón, José Juan, Navarro, Carmen, Castaño-Vinyals, Gemma, Kogevinas, Manolis, Pollán, Marina, de Sanjosé, Silvia, del Campo, Rosa, Waterboer, Tim, and Aragonés, Nuria

Published
2017
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12. Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study

Author

Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Guerrero-Zotano, Ángel, Casas, Ana María, Bermejo, Begoña, Baena-Cañada, José Manuel, Antolin, Silvia, Sánchez-Rovira, Pedro, Ramos Vázquez, Manuel, Garcia-Sáenz, José Ángel, Antón, Antonio, Muñoz, Montserrat, de Juan, Ana, Jara, Carlos, Chacón, José Ignacio, Arcusa, Angels, Gil-Gil, Miguel, Adrover, Encarna, Oltra, Amparo, Brunet, Joan, González, Sonia, Bezares, Susana, Lope, Virginia, Martín, Miguel, and Pollán, Marina

Published
2020
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13. A nation‐wide analysis of socioeconomic and geographical disparities in the prevalence of obesity and excess weight in children and adolescents in Spain: Results from the ENE‐COVID study.

Author

Gutiérrez‐González, Enrique, García‐Solano, Marta, Pastor‐Barriuso, Roberto, Fernández de Larrea‐Baz, Nerea, Rollán‐Gordo, Almudena, Peñalver‐Argüeso, Belén, Peña‐Rey, Isabel, Pollán, Marina, and Pérez‐Gómez, Beatriz

Subjects
STATURE, SOCIAL determinants of health, BODY weight, CHILDHOOD obesity, SELF-evaluation, POPULATION geography, SOCIOECONOMIC factors, SEX distribution, SURVEYS, INCOME, DISEASE prevalence, QUESTIONNAIRES, SOCIAL classes, DESCRIPTIVE statistics, HEALTH equity, BODY mass index
Abstract

Summary: Objective: To estimate national and provincial prevalence of obesity and excess weight in the child and adolescent population in Spain by sex and sociodemographic characteristics, and to explore sources of inequalities in their distribution, and their geographical patterns. Methods: ENE‐COVID is a nationwide representative seroepidemiological survey (68 287 participants) stratified by province and municipality size (April–June 2020). Participants answered a questionnaire which collected self‐reported weight and height, that allowed estimating crude and model‐based standardized prevalences of obesity and excess weight in the 10 543 child and adolescent participants aged 2–17 years. Results: Crude prevalences (WHO growth reference) were higher in boys than in girls (obesity: 13.4% vs. 7.9%; excess weight: 33.7% vs. 26.0%; severe obesity: 2.9% vs. 1.2%). These prevalences varied with age, increased with the presence of any adult with excess weight in the household, while they decreased with higher adult educational and census tract average income levels. Obesity by province ranged 1.8%–30.5% in boys and 0%–17.6% in girls; excess weight ranged 15.2%–49.9% in boys and 10.8%–40.8% in girls. The lowest prevalences of obesity and excess weight were found in provinces in the northern half of Spain. Sociodemographic characteristics only partially explained the observed geographical variability (33.6% obesity; 44.2% excess weight). Conclusions: Childhood and adolescent obesity and excess weight are highly prevalent in Spain, with relevant sex, sociodemographic and geographical differences. The geographic variability explained by sociodemographic variables indicates that there are other potentially modifiable factors on which to focus interventions at different geographic levels to fight this problem. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Smoking history and breast cancer risk by pathological subtype: MCC-Spain study.

Author

Peñalver-Argüeso, Belén, García-Esquinas, Esther, Castelló, Adela, Fernández de Larrea-Baz, Nerea, Castaño-Vinyals, Gemma, Amiano, Pilar, Fernández-Villa, Tania, Guevara, Marcela, Fernández-Tardón, Guillermo, Alguacil, Juan, Obón-Santacana, Mireia, Gómez-Acebo, Inés, Pinto-Carbó, Marina, Marcos-Gragera, Rafael, Aragonés, Nuria, Aizpurua, Amaia, Martín-Sánchez, Vicente, Ardanaz, Eva, Dierssen-Sotos, Trinidad, and Jiménez-Moleón, Jose Juan

Subjects
BREAST tumor risk factors, OBESITY, CONFIDENCE intervals, DISEASES, RESEARCH funding, POSTMENOPAUSE, SMOKING, LOGISTIC regression analysis, ODDS ratio
Abstract

INTRODUCTION The role of cigarette smoking on breast cancer risk remains controversial, due to its dual carcinogenic-antiestrogenic action. METHODS In the population-based multi-case-control study (MCC-Spain), we collected epidemiological and clinical information for 1733 breast cancer cases and 1903 controls, including smoking exposure. The association with breast cancer, overall, by pathological subtype and menopausal status, was assessed using logistic and multinomial regression models. RESULTS Smokers had higher risk of premenopausal breast cancer, particularly if they had smoked ≥30 years (AOR=1.75; 95% CI: 1.04-2.94), although most estimates did not achieve statistical significance. In contrast, among postmenopausal women, smoking was associated with lower risk of breast cancer, mainly in overweight and obese women. The strongest risk reductions were observed among postmenopausal women who had stopped smoking ≥10 years before cancer diagnosis, particularly for HER2+ tumors (AOR=0.28; 95% CI: 0.11-0.68); p for heterogeneity = 0.040). Also, those who had smoked <10 pack-years (AOR=0.68; 95% CI: 0.47-0.98) or 10-25 pack-years (AOR=0.62; 95% CI: 0.42-0.92) during their lifetime were at a reduced risk of all breast cancer subtypes (p for heterogeneity: 0.405 and 0.475, respectively); however, women who had smoked more than 25 pack-years showed no reduced risk. CONCLUSIONS Menopausal status plays a key role in the relationship between tobacco and breast cancer for all cancer subtypes. While smoking seems to increase the risk in premenopausal woman, it might be associated to lower risk of breast cancer among postmenopausal women with excess weight. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Clinical and Sociodemographic Determinants of Adherence to World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) Recommendations in Breast Cancer Survivors—Health-EpiGEICAM Study

Author

Lope, Virginia, primary, Guerrero-Zotano, Angel, additional, Ruiz-Moreno, Emma, additional, Bermejo, Begoña, additional, Antolín, Silvia, additional, Montaño, Álvaro, additional, Baena-Cañada, José Manuel, additional, Ramos Vázquez, Manuel, additional, Fernández de Larrea-Baz, Nerea, additional, Chacón, José Ignacio, additional, García-Sáenz, José Angel, additional, Olier, Clara, additional, Muñoz, Montserrat, additional, Antón, Antonio, additional, Sánchez Rovira, Pedro, additional, Arcusa Lanza, Angels, additional, González, Sonia, additional, Oltra, Amparo, additional, Brunet, Joan, additional, Gavilá Gregori, Joaquín, additional, Martínez, María Teresa, additional, Calvo, Lourdes, additional, Rosell, Libertad, additional, Bezares, Susana, additional, Pastor-Barriuso, Roberto, additional, Pérez-Gómez, Beatriz, additional, Martín, Miguel, additional, and Pollán, Marina, additional

Published
2022
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18. Residential proximity to industrial pollution and mammographic density

Author

Jiménez, Tamara, primary, Pollán, Marina, additional, Domínguez-Castillo, Alejandro, additional, Lucas, Pilar, additional, Sierra, María Ángeles, additional, Fernández de Larrea-Baz, Nerea, additional, González-Sánchez, Mario, additional, Salas-Trejo, Dolores, additional, Llobet, Rafael, additional, Martínez, Inmaculada, additional, Pino, Marina Nieves, additional, Martínez-Cortés, Mercedes, additional, Pérez-Gómez, Beatriz, additional, Lope, Virginia, additional, and García-Pérez, Javier, additional

Published
2022
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19. Sociodemographic and Lifestyle Determinants of Adherence to Current Dietary Recommendations and Diet Quality in Middle-Aged Spanish Premenopausal Women

Author

Alonso-Cabezas, Marina, primary, Pollán, Marina, additional, Alonso-Ledesma, Isabel, additional, Fernández de Larrea-Baz, Nerea, additional, Lucas, Pilar, additional, Sierra, Ángeles, additional, Castelló, Adela, additional, Pino, Marina Nieves, additional, Pérez-Gómez, Beatriz, additional, Martínez-Cortés, Mercedes, additional, Lope, Virginia, additional, and Ruiz-Moreno, Emma, additional

Published
2022
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22. Meat intake, cooking methods, doneness preferences and risk of gastric adenocarcinoma in the MCC-Spain Study

Author

Boldo, Elena, Fernández de Larrea-Baz, Nerea, Pollán, Marina, Martín, Vicente, Obón-Santacana, Mireia, Guevara, Marcela, Castaño Vinyals, Gemma, Canga, Jose María, Pérez-Gómez, Beatriz, Gómez-Acebo, Inés, Fernández-Tardón, Guillermo, Vanaclocha-Espi, Mercedes, Olmedo-Requena, Rocío, Alguacil Ojeda, Juan, Chirlaque, María Dolores, Kogevinas, Manolis, Aragonés, Núria, Castelló, Adela, MCC-Spain researchers, Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Ministerio de Economía y Competitividad (España), Fundación Marqués de Valdecilla, Junta de Castilla y León (España), Centro de Investigación Biomédica en Red - CIBERESP (Epidemiología y Salud Pública), Government of Catalonia (España), Regional Government of Andalusia (España), Generalitat Valenciana (España), University of Oviedo (España), Fundación Cajastur, Ministerio de Ciencia e Innovación. Centro de Excelencia Severo Ochoa (España), Plan Nacional de I+D+i (España), Asociación Española Contra el Cáncer, and Universidad de Cantabria

Subjects
Male, Nutrition and Dietetics, Meat, Red meat, Helicobacter pylori, Cooking (Meat), Processed meat, Stomach neoplasms, Doneness preference, Adenocarcinoma, 3212 Salud Publica, Malalties de l'estómac, Helicobacter Infections, Cuina (Carn), stomach neoplasms, red meat, processed meat, cooking methods, doneness preference, Spain, Case-Control Studies, Cooking methods, Humans, Cooking, Stomach diseases, Food Science
Abstract

Background: The association of meat intake with gastric adenocarcinoma is controversial. We examined the relation between white, red, and processed meat intake and gastric adenocarcinoma, considering doneness preference and cooking methods, by histological subtype and anatomical subsite. Methods: MCC-Spain is a multicase–control study that included 286 incident gastric adenocarcinoma cases and 2993 controls who answered a food-frequency questionnaire. The association of gastric adenocarcinoma with meat intake, doneness preference and cooking methods was assessed using binary multivariate logistic regression mixed models and a possible interaction with sex was considered. Multinomial logistic regression models were used to estimate risk by tumor subsite (cardia vs. non-cardia) and subtype (intestinal vs. diffuse). Sensitivity analyses were conducted comparing models with and without data on Helicobacter pylori infection. Results: The intake of red and processed meat increased gastric adenocarcinoma risk (OR for one serving/week increase (95% CI) = 1.11 (1.02;1.20) and 1.04 (1.00;1.08), respectively), specifically among men and for noncardia and intestinal gastric adenocarcinoma. Those who consume well done white or red meat showed higher risk of non-cardia (white: RRR = 1.57 (1.14;2.16); red: RRR = 1.42 (1.00;2.02)) and intestinal tumors (white: RRR = 1.69 (1.10;2.59); red: RRR = 1.61 (1.02;2.53)) than those with a preference for rare/medium doneness. Stewing and griddling/barbequing red and white meat, and oven baking white meat, seemed to be the cooking methods with the greatest effect over gastric adenocarcinoma. The reported associations remained similar after considering Helicobacter pylori seropositivity. Conclusions: Reducing red and processed meat intake could decrease gastric adenocarcinoma risk, especially for intestinal and non-cardia tumors. Meat cooking practices could modify the risk of some gastric cancer subtypes., FEDER funds-a way to build Europe PI08/1770 PI09/00773 PS09/01286 PI09/1903 PI09/1662 PI09/2078 PI11/01403, Spanish Government IJCI-2014-20900, Instituto de Salud Carlos III API 10/09, Junta de Castilla y Leon LE22A10-2, Instituto de Salud Carlos III, CIBER of Epidemiology and Public Health (CIBERESP), Catalan Government DURSI 2014SGR647 2014SGR756, Junta de Andalucia 2009-S0143, Conselleria de Sanitat of the Generalitat Valenciana AP061/10, University of Oviedo, IUOPA, Fundacion Caja de Asturias, Spanish Ministry of Science and Innovation through the "Centro de Excelencia Severo Ochoa" Program CEX2018-000806-S, Generalitat de Catalunya through the CERCA Program, Ministry of Economy and Competitiveness (Bolsa de Ampliacion de Estudios. Accion Estrategica en Salud del Plan Nacional I+D+i), Spanish Association Against Cancer Scientific Foundation (AECC) POSTD037OBON, Instituto de Salud Carlos III European Commission RD09/0076/00036 RD 09 0076/00021 RD09 0076/00058, Catalan Institute of Oncology, ISCIII Biobank, IUOPA Biobank of the University of Oviedo

Published
2022

24. Residential proximity to industrial pollution and mammographic density

Author

Jiménez, Tamara, Pollán, Marina, Domínguez-Castillo, Alejandro, Lucas, Pilar, Sierra, María Ángeles, Fernández de Larrea-Baz, Nerea, González-Sánchez, Mario, Salas-Trejo, Dolores, Llobet Azpitarte, Rafael, Martinez, Inmaculada, Pino, María Nieves, Martínez-Cortés, Mercedes, Pérez-Gómez, Beatriz, Lope, Virginia, and García-Pérez, Javier

Subjects
Environmental Engineering, Breast Neoplasms, Pollution, Cross-Sectional Studies, Risk Factors, Case-Control Studies, Environmental Chemistry, Humans, Environmental Pollutants, Female, Environmental Pollution, LENGUAJES Y SISTEMAS INFORMATICOS, Waste Management and Disposal, Breast Density
Abstract

[EN] Background: Mammographic density (MD), expressed as percentage of fibroglandular breast tissue, is an important risk factor for breast cancer. Our objective is to investigate the relationship between MD and residential proximity to pol-lutant industries in premenopausal Spanish women. MeOds: A cross-sectional study was carried out in a sample of 1225 women extracted from the DDM-Madrid study. Multiple linear regression models were used to assess the association of MD percentage (and their 95% confidence in-tervals (95%CIs)) and proximity (between 1 km and 3 km) to industries included in the European Pollutant Release and Transfer Register. Results: Although no association was found between MD and distance to all industries as a whole, several industrial sectors showed significant association for some distances: "surface treatment of metals and plastic" (j3 = 4.98, 95%CI = (0.85; 9.12) at, We would like to thank the participants in the DDM-Madrid study for their contribution to breast cancer research. This work was supported by the Carlos III Institute of Health (AESI PI15CIII/0029, AESI PI15CIII/00013, and EPY-505/19-PFIS) . The article presents independent research. The views expressed are those of the authors and not necessarily those of the Carlos III Institute of Health.

Published
2021

25. Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women

Author

Toribio, María José, primary, Priego-Capote, Feliciano, additional, Pérez-Gómez, Beatriz, additional, Fernández de Larrea-Baz, Nerea, additional, Ruiz-Moreno, Emma, additional, Castelló, Adela, additional, Lucas, Pilar, additional, Sierra, María Ángeles, additional, Pino, Marina Nieves, additional, Martínez-Cortés, Mercedes, additional, Luque de Castro, María Dolores, additional, Lope, Virginia, additional, and Pollán, Marina, additional

Published
2021
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26. Influence of depression on survival of colorectal cancer patients drawn from a large prospective cohort.

Author

Varela‐Moreno, Esperanza, Rivas‐Ruiz, Francisco, Padilla‐Ruiz, María, Alcaide‐García, Julia, Zarcos‐Pedrinaci, Irene, Téllez, Teresa, Fernández‐de Larrea‐Baz, Nerea, Baré, Marisa, Bilbao, Amaia, Sarasqueta, Cristina, Morales‐Suárez‐Varela, María Manuela, Aguirre, Urko, Quintana, José María, Redondo, Maximino, Varela-Moreno, Esperanza, Rivas-Ruiz, Francisco, Padilla-Ruiz, María, Alcaide-García, Julia, Zarcos-Pedrinaci, Irene, and Larrea-Baz, Nerea Fernández-de

Subjects
RESEARCH, RESEARCH methodology, EVALUATION research, COLORECTAL cancer, COMPARATIVE studies, MENTAL depression, RESEARCH funding, LONGITUDINAL method, PROPORTIONAL hazards models
Abstract

Objective: The prevalence of depressive symptoms immediately after the diagnosis of colorectal cancer (CRC) is high and has important implications both psychologically and on the course of the disease. The aim of this study is to analyse the association between depressive symptoms and CRC survival at 5 years after diagnosis.Methods: This multicentre, prospective, observational cohort study was conducted on a sample of 2602 patients with CRC who completed the Hospital Anxiety and Depression Scale (HADS-D) at 5 years of follow-up. Survival was analysed using the Kaplan-Meier method and Cox regression models.Results: According to our analysis, the prevalence of depressive symptoms after a CRC diagnosis was 23.8%. The Cox regression analysis identified depression as an independent risk factor for survival (HR = 1.47; 95% CI: 1.21-1.8), a finding which persisted after adjusting for sex (female: HR = 0.63; 95% CI: 0.51-0.76), age (>70 years: HR = 3.78; 95% CI: 1.94-7.36), need for help (yes: HR = 1.43; 95% CI: 1.17-1.74), provision of social assistance (yes: HR = 1.46; 95% CI: 1.16-1.82), tumour size (T3-T4: HR = 1.56; 95% CI: 1.22-1.99), nodule staging (N1-N2: HR = 2.46; 95% CI: 2.04-2.96), and diagnosis during a screening test (yes: HR = 0.71; 95% CI: 0.55-0.91).Conclusions: There is a high prevalence of depressive symptoms in patients diagnosed with CRC. These symptoms were negatively associated with the survival rate independently of other clinical variables. Therefore, patients diagnosed with CRC should be screened for depressive symptoms to ensure appropriate treatment can be provided. [ABSTRACT FROM AUTHOR]

Published
2022
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27. Toxic metals in toenails as biomarkers of exposure: A review

Author

Salcedo-Bellido, Inmaculada, primary, Gutiérrez-González, Enrique, additional, García-Esquinas, Esther, additional, Fernández de Larrea-Baz, Nerea, additional, Navas-Acien, Ana, additional, Téllez-Plaza, María, additional, Pastor-Barriuso, Roberto, additional, Lope, Virginia, additional, Gómez-Ariza, José Luis, additional, García-Barrera, Tamara, additional, Pollán, Marina, additional, Jiménez Moleón, José Juan, additional, and Pérez-Gómez, Beatriz, additional

Published
2021
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28. Risk of gastric cancer in the environs of industrial facilities in the MCC-Spain study

Author

García-Pérez, Javier, primary, Lope, Virginia, additional, Fernández de Larrea-Baz, Nerea, additional, Molina, Antonio J., additional, Tardón, Adonina, additional, Alguacil, Juan, additional, Pérez-Gómez, Beatriz, additional, Moreno, Víctor, additional, Guevara, Marcela, additional, Castaño-Vinyals, Gemma, additional, Jiménez-Moleón, José J., additional, Gómez-Acebo, Inés, additional, Molina-Barceló, Ana, additional, Martín, Vicente, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, and Aragonés, Nuria, additional

Published
2021
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29. Composition and Nutritional Quality of the Diet in Spanish Households during the First Wave of the COVID-19 Pandemic

Author

Del Pozo De La Calle, Susana, Alonso Ledesma, Isabel, Nuñez, Olivier, Castelló Pastor, Adela, Lope Carvajal, Virginia, Fernández de Larrea Baz, Nerea, Pérez Gómez, Beatriz, Pollán, Marina, Ruiz Moreno, Emma, Del Pozo De La Calle, Susana, Alonso Ledesma, Isabel, Nuñez, Olivier, Castelló Pastor, Adela, Lope Carvajal, Virginia, Fernández de Larrea Baz, Nerea, Pérez Gómez, Beatriz, Pollán, Marina, and Ruiz Moreno, Emma

Abstract

In Spain, the health crisis caused by the COVID-19 pandemic led to the declaration of a state of alarm in the whole country in 2020; in this context, a nationwide lockdown was implemented, potentially altering the dietary habits of the population. The aims of this study were to describe the diet and its nutritional quality in Spanish households during the first COVID-19 epidemic wave and to compare them with the same period in 2019. Data on monthly foods and beverages household purchases in 2019 and 2020 were obtained from the nationwide Food Consumption Surveys. In April, there was an average increase, compared with 2019, of more than 40% for all food groups, with significant peaks in: alcoholic beverages (75%), appetizers (60%), eggs (59%), sugar and sweets (52%), and vegetables (50%). In March, the greatest peak was for pulses, with a 63% increment. The mean energy value of purchased foods in April was 2801 kcal/person/day, corresponding to an increase of 771 kcal/person/day (+38%), compared to the same month of 2019 (March and May: +520 kcal (+26%), June: +343 kcal (+18%)). Regarding nutrient density, there was a reduction in calcium, iodine, zinc, selenium, riboflavin, vitamins B12, D, A, especially retinol, and an increase in fibre, sodium, folic acid, carotenes and vitamin E. Alcohol content per 1000 kcal increased by more than 20% from April to July. Food purchase patterns in Spanish households changed during lockdown and after it, with no appreciable improvement in the quality of the diet., Sección Dptal. de Nutrición y Ciencia de los Alimentos (Veterinaria), Fac. de Veterinaria, TRUE, pub

Published
2021

30. Trajectories of alcohol consumption during life and the risk of developing breast cancer

Author

Medicina, Donat-Vargas, Carolina, Guerrero-Zotano, Ángel, Casas, Ana, Baena Cañada, José Manuel, Lope, Virginia, Antolín, Silvia, García-Sáenz, José Ángel, Bermejo, Begoña, Muñoz, Montserrat, Ramos, Manuel, de Juan, Ana, Jara Sánchez, Carlos, Sánchez-Rovira, Pedro, Antón, Antonio, Brunet, Joan, Gavilá, Joaquín, Salvador, Javier, Arriola Arellano, Esperanza, Bezares, Susana, Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Martín, Miguel, Pollán, Marina, Medicina, Donat-Vargas, Carolina, Guerrero-Zotano, Ángel, Casas, Ana, Baena Cañada, José Manuel, Lope, Virginia, Antolín, Silvia, García-Sáenz, José Ángel, Bermejo, Begoña, Muñoz, Montserrat, Ramos, Manuel, de Juan, Ana, Jara Sánchez, Carlos, Sánchez-Rovira, Pedro, Antón, Antonio, Brunet, Joan, Gavilá, Joaquín, Salvador, Javier, Arriola Arellano, Esperanza, Bezares, Susana, Fernández de Larrea-Baz, Nerea, Pérez-Gómez, Beatriz, Martín, Miguel, and Pollán, Marina

Abstract

Background Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). Methods 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Results Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (>= 15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, >= 15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. Conclusions The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.

Published
2021

34. Development of Helicobacter pylori Whole-Proteome Arrays and Identification of Serologic Biomarkers for Noncardia Gastric Cancer in the MCC-Spain Study

Author

Jeske, Rima, primary, Reininger, Dennis, additional, Turgu, Busra, additional, Brauer, Amber, additional, Harmel, Christoph, additional, Fernández de Larrea-Baz, Nerea, additional, Martín, Vicente, additional, Moreno, Victor, additional, Kogevinas, Manolis, additional, Pollán, Marina, additional, Hoheisel, Jörg D., additional, Waterboer, Tim, additional, Butt, Julia, additional, Aragonés, Nuria, additional, and Hufnagel, Katrin, additional

Published
2020
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35. Marcadores serológicos de riesgo de cáncer gástrico y colorrectal relacionados con la infección por Helicobacter pylori

Author

Fernández de Larrea Baz, Nerea, Aragonés Sanz, Nuria, and UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología

Subjects
Medicina, Colon - Cáncer - Tesis, Estómago - Cáncer - Inmunología, Estómago - Cáncer - Tesis, Recto - Cáncer - Tesis
Abstract

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina Preventiva, Salud Pública y Microbiología . Fecha de lectura: 11-06-2019

Published
2019

36. Biological and prognostic differences between symptomatic colorectal carcinomas and those detected by screening

Author

Téllez, Teresa, primary, Abitei, Cristina, additional, Padilla-Ruiz, María del Carmen, additional, Rivas-Ruiz, Francisco, additional, Fúnez, Rafael, additional, Pereda, Teresa, additional, Rodrigo, Isabel, additional, Alcaide, Julia, additional, Baré, María Luisa, additional, Morales Suárez-Varela, María Manuela, additional, Zabalza, Iñaki, additional, Sánchez del Charco, Matilde, additional, Borrero Martín, Juan José, additional, García del Moral, Raimundo, additional, Escobar, Antonio, additional, Quintana, José María, additional, Aguirre, Urko, additional, Redondo, Maximino, additional, Quintana Lopez, José María, additional, Mañas, Marisa Baré, additional, Bautista, Maximino Redondo, additional, Pérez de la Blanca, Eduardo Briones, additional, Fernández de Larrea Baz, Nerea, additional, Eizaguirre, Cristina Sarasqueta, additional, Martínez, Antonio Escobar, additional, Ruiz, Francisco Rivas, additional, Morales-Suárez-Varela, María M., additional, Blasco Amaro, Juan Antonio, additional, Gonzalez, Isabel del Cura, additional, Madariaga, Inmaculada Arostegui, additional, González, Amaia Bilbao, additional, Hernandez, Nerea González, additional, García-Gutiérrez, Susana, additional, Guerrero, Iratxe Lafuente, additional, Larracoechea, Urko Aguirre, additional, Calzada, Miren Orive, additional, Corral, Josune Martin, additional, Anton-Ladislao, Ane, additional, Torà, Nuria, additional, Pont, Marina, additional, Martínez del Prado, María Purificación, additional, Totorikaguena, Alberto Loizate, additional, Estevez, Ignacio Zabalza, additional, Alustiza, José Errasti, additional, Gimeno García, Antonio Z., additional, Aramburu, Santiago Lázaro, additional, Serrano, Mercè Comas, additional, Enríquez Navascues, José María, additional, Galan, Carlos Placer, additional, Perales, Amaia, additional, Valmaña, Iñaki Urkidi, additional, Erro Azkárate, José María, additional, Lizarribar, Enrique Cormenzana, additional, Muñoa, Adelaida Lacasta, additional, Pibernat, Pep Piera, additional, Cuevas, Elena Campano, additional, Sotelo Gómez, Ana Isabel, additional, Abril, Segundo Gómez, additional, Medina-Cano, F., additional, Del Rey-Moreno, Arturo, additional, Alcántara, Manuel Jesús, additional, Campo, Rafael, additional, Casalots, Alex, additional, Pericay, Carles, additional, Gil, María José, additional, Pera, Miquel, additional, Collera, Pablo, additional, Espinàs, Josep Alfons, additional, Martínez, Mercedes, additional, Espallargues, Mireia, additional, Almazán, Caridad, additional, Lindenbaum, Paula Dujovne, additional, Fernández-Cebrián, José María, additional, Fernández, Rocío Anula, additional, Mayol Martínez, Julio Ángel, additional, Cid, Ramón Cantero, additional, Labajo, Héctor Guadalajara, additional, Garceau, María Heras, additional, Olmo, Damián García, additional, Montalvo, Mariel Morey, additional, and Mar, Javier, additional

Published
2019
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38. Burden of disease due to cancer in Spain

Author

Pérez-Gómez Beatriz, Gil Ángel, Gènova-Maleras Ricard, Morant-Ginestar Consuelo, Álvarez-Martín Elena, Fernández de Larrea-Baz Nerea, and López-Abente Gonzalo

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Burden of disease is a joint measure of mortality and morbidity which makes it easier to compare health problems in which these two components enjoy different degrees of relative importance. The objective of this study is ascertaining the burden of disease due to cancer in Spain via the calculation of disability-adjusted life years (DALYs). Methods DALYs are the sum of years of life lost due to premature mortality and years lost due to disability. World Health Organization methodology and the following sources of data were used: the Mortality Register and Princeton Model Life Table for Years of life lost due to premature mortality and population, incidence estimates (Spanish tumour registries and fitting of generalized linear mixed models), duration (from data of survival in Spain from the EUROCARE-3 study and fitting of Weibull distribution function) and disability (weights published in the literature) for Years lost due to disability. Results There were 828,997 DALYs due to cancer (20.5 DALYs/1,000 population), 61% in men. Of the total, 51% corresponded to lung, colorectal, breast, stomach and prostate cancers. Mortality (84% of DALYs) predominated over disability. Subjects aged under 20 years accounted for 1.6% and those aged over 70 years accounted for 30.1% of DALYs. Conclusion Lung, colorectal and breast cancers are responsible for the highest number of DALYs in Spain. Even if the burden of disease due to cancer is predominantly caused by mortality, some cancers have a significant weight of disability. Information on 2000 burden of disease due to cancer can be useful to assess how it has evolved over time and the impact of medical advances on it in terms of mortality and disability.

Published
2009
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39. Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

Author

Fernández de Larrea Baz, Nerea, Michel, Angelika, Romero, Beatriz, Pérez Gómez, Beatriz, Moreno, Victor, Martín, Vicente, Dierssen Sotos, Trinidad, Jiménez Moleón, José Juan, Castilla, Jesús, Tardón, Adonina, Ruiz, Irune, Peiró Pérez, Rosana, Tejada, Antonio, Chirlaque, María D., Butt, Julia A., Olmedo Requena, Rocío, Gómez Acebo, Inés, Linares, Pedro, Boldo, Elena, Castells, Antoni, and Universidad de Cantabria

Abstract

Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to ?4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results:H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag? showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.

Published
2017

40. Outcomes of open versus laparoscopic surgery in patients with colon cancer

Author

Quintana, José M., primary, Antón-Ladisla, Ane, additional, González, Nerea, additional, Lázaro, Santiago, additional, Baré, Marisa, additional, Fernández de Larrea, Nerea, additional, Redondo, Maximino, additional, Briones, Eduardo, additional, Escobar, Antonio, additional, Sarasqueta, Cristina, additional, García-Gutierrez, Susana, additional, Quintana López, Jose María, additional, Mañas, Marisa Baré, additional, Bautista, Maximino Redondo, additional, Pérez de la Blanca, Eduardo Briones, additional, Fernández de Larrea Baz, Nerea, additional, Eizaguirre, Cristina Sarasqueta, additional, Martínez, Antonio Escobar, additional, Ruiz, Francisco Rivas, additional, Morales-Suárez-Varela, Maria M., additional, Blasco Amaro, Juan Antonio, additional, González, Isabel del Cura, additional, Madariaga, Inmaculada Arostegui, additional, González, Amaia Bilbao, additional, Hernández, Nerea González, additional, García-Gutiérrez, Susana, additional, Guerrero, Iratxe Lafuente, additional, Larracoechea, Urko Aguirre, additional, Calzada, Miren Orive, additional, Corral, Josune Martin, additional, Antón-Ladislao, Ane, additional, Torà, Núria, additional, Pont, Marina, additional, Martínez del Prado, María Purificación, additional, Totorikaguena, Alberto Loizate, additional, Estévez, Ignacio Zabalza, additional, Alustiza, José Errasti, additional, Gimeno García, Antonio Z., additional, Aramburu, Santiago Lázaro, additional, Serrano, Mercè Comas, additional, Enríquez Navascues, Jose María, additional, Galán, Carlos Placer, additional, Perales, Amaia, additional, Valmaña, Iñaki Urkidi, additional, Erro Azkárate, Jose María, additional, Lizarribar, Enrique Cormenzana, additional, Muñoa, Adelaida Lacasta, additional, Pibernat, Pep Piera, additional, Cuevas, Elena Campano, additional, Sotelo Gómez, Ana Isabel, additional, Gómez-Abril, Segundo, additional, Medina-Cano, F., additional, Alcaide, Julia, additional, Del Rey-Moreno, Arturo, additional, Alcántara, Manuel Jesús, additional, Campo, Rafael, additional, Casalots, Alex, additional, Pericay, Carles, additional, Gil, Maria José, additional, Pera, Miquel, additional, Collera, Pablo, additional, Espinàs, Josep Alfons, additional, Martínez, Mercedes, additional, Espallargues, Mireia, additional, Almazán, Caridad, additional, Lindenbaum, Paula Dujovne, additional, Fernández-Cebrián, José María, additional, Fernández, Rocío Anula, additional, Mayol Martínez, Julio Ángel, additional, Cid, Ramón Cantero, additional, Labajo, Héctor Guadalajara, additional, Garceau, María Heras, additional, Olmo, Damián García, additional, Montalvo, Mariel Morey, additional, and Mar, Javier, additional

Published
2018
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41. Determinants of change in physical activity during moderate-to-severe COPD exacerbation

Author

Esteban, Cristóbal, Quintana, José María, García Gutiérrez, Susana, Antón Ladislao, Ane, González, Nerea, Baré, Marisa, Fernández de Larrea-Baz, Nerea, Rivas Ruiz, Francisco, Gea Guiral, Joaquim, and IRYSS-COPD group

Subjects
Male, Pulmons -- Malalties obstructives, Symptom Flare Up, physical activity, Severity of Illness Index, Cholinergic Antagonists, Cohort Studies, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Quality of life, Risk Factors, 030212 general & internal medicine, Prospective Studies, Prospective cohort study, Original Research, COPD, General Medicine, Middle Aged, Prognosis, Hospitalization, COPD exacerbations, Disease Progression, Female, Cohort study, medicine.medical_specialty, Physical activity, Exercici, International Journal of Chronic Obstructive Pulmonary Disease, Motor Activity, Risk Assessment, 03 medical and health sciences, Internal medicine, Severity of illness, medicine, Humans, Glucocorticoids, Aged, prospective cohort study, business.industry, medicine.disease, 030228 respiratory system, Copd exacerbation, Spain, Quality of Life, sense organs, business
Abstract

Cristóbal Esteban,1,2 José M Quintana,2,3 Susana Garcia-Gutierrez,2,3 Ane Anton-Ladislao,3 Nerea Gonzalez,2,3 Marisa Baré,2,4 Nerea Fernández de Larrea,2,5 Francisco Rivas-Ruiz2,6 For the IRYSS-COPD group 1Respiratory Department, Hospital Galdakao-Usansolo, Bizkaia; 2Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Galdakao; 3Research Unit, Hospital Galdakao-Usansolo, Bizkaia; 4Unit of Clinical Epidemiology, Corporacio Parc Tauli, Barcelona; 5Health Department, Madrid; 6Research Unit, Hospital Costa del Sol, Mabella, Málaga, Spain Background: Data are scarce on patient physical activity (PA) level during exacerbations of chronic obstructive pulmonary disease (eCOPD). The objective of the study was to evaluate the level and determinants of change in PA during an eCOPD. Materials and methods: We conducted a prospective cohort study with recruitment from emergency departments (EDs) of 16 participating hospitals from June 2008 to September 2010. Data were recorded on socioeconomic characteristics, dyspnea, forced expiratory volume in 1 second (FEV1%), comorbidities, health-related quality of life, factors related to exacerbation, and PA in a stable clinical condition and during the eCOPD episode. Results: We evaluated 2,487 patients. Common factors related to the change in PA during hospital admission or 7 days after discharge to home from the ED were lower PA at baseline and during the first 24 hours after the index evaluation. Age, quality of life, living alone, length of hospital stay, and use of anticholinergic or systemic corticosteroids in treating the exacerbation were associated with the change in PA among hospitalized patients. Predictors of change among patients not admitted to hospital were baseline FEV1% and dyspnea at rest on ED arrival. Conclusion: Among the patients evaluated in an ED for an eCOPD, the level and change in PA was markedly variable. Factors associated with exacerbation (PA 24 hours after admission, medication during admission, and length of hospital stay) and variables reflecting patients’ stable clinical condition (low level of PA, age, quality of life, FEV1%) are predictors of the change in PA during a moderate-to-severe eCOPD.Keywords: COPD exacerbations, physical activity, prospective cohort study

Published
2016

42. Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

Author

Fernández de Larrea-Baz, Nerea, primary, Michel, Angelika, additional, Romero, Beatriz, additional, Pérez-Gómez, Beatriz, additional, Moreno, Victor, additional, Martín, Vicente, additional, Dierssen-Sotos, Trinidad, additional, Jiménez-Moleón, José J., additional, Castilla, Jesús, additional, Tardón, Adonina, additional, Ruiz, Irune, additional, Peiró, Rosana, additional, Tejada, Antonio, additional, Chirlaque, María D., additional, Butt, Julia A., additional, Olmedo-Requena, Rocío, additional, Gómez-Acebo, Inés, additional, Linares, Pedro, additional, Boldo, Elena, additional, Castells, Antoni, additional, Pawlita, Michael, additional, Castaño-Vinyals, Gemma, additional, Kogevinas, Manolis, additional, de Sanjosé, Silvia, additional, Pollán, Marina, additional, del Campo, Rosa, additional, Waterboer, Tim, additional, and Aragonés, Nuria, additional

Published
2017
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43. Predictive score for mortality in patients with COPD exacerbations attending hospital emergency departments

Author

Quintana, José María, Esteban, Cristóbal, Unzurrunzaga, Anette, García Gutiérrez, Susana, González, Nerea, Barrio, Irantzu, Arostegui, Inmaculada, Lafuente, Iratxe, Baré, Marisa, Fernández de Larrea-Baz, Nerea, Vidal, Silvia, Estirado Vera, Cristina, 1968, Gea Guiral, Joaquim, and IRYSS-COPD group

Subjects
Male, Pulmons -- Malalties obstructives, Exacerbation, diagnosis, medicine.medical_treatment, severity, Clinical prediction rule, burden, Cohort Studies, Pulmonary Disease, Chronic Obstructive, prevention, Medicine, Prospective Studies, Prospective cohort study, Medicine(all), validation, COPD, Framingham Risk Score, General Medicine, Middle Aged, risk-score, Patient Discharge, Hospitalization, clinical-features, COPD exacerbations, Disease Progression, Female, Emergency Service, Hospital, management, Research Article, Cohort study, metaanalysis, medicine.medical_specialty, risk analysis, Decision Making, Decision Support Techniques, Humans, structure, Músculs respiratoris -- Malalties, Aged, prediction rule, Mechanical ventilation, prospective cohort study, business.industry, obstructive pulmory-disease, MEDICINE, Emergency department, medicine.disease, mortality, Logistic Models, Emergency medicine, Physical therapy, business
Abstract

Background: Limited information is available about predictors of short-term outcomes in patients with exacerbation of chronic obstructive pulmonary disease (eCOPD) attending an emergency department (ED). Such information could help stratify these patients and guide medical decision-making. The aim of this study was to develop a clinical prediction rule for short-term mortality during hospital admission or within a week after the index ED visit. Methods: This was a prospective cohort study of patients with eCOPD attending the EDs of 16 participating hospitals. Recruitment started in June 2008 and ended in September 2010. Information on possible predictor variables was recorded during the time the patient was evaluated in the ED, at the time a decision was made to admit the patient to the hospital or discharge home, and during follow-up. Main short-term outcomes were death during hospital admission or within 1 week of discharge to home from the ED, as well as at death within 1 month of the index ED visit. Multivariate logistic regression models were developed in a derivation sample and validated in a validation sample. The score was compared with other published prediction rules for patients with stable COPD. Results: In total, 2,487 patients were included in the study. Predictors of death during hospital admission, or within 1 week of discharge to home from the ED were patient age, baseline dyspnea, previous need for long-term home oxygen therapy or non-invasive mechanical ventilation, altered mental status, and use of inspiratory accessory muscles or paradoxical breathing upon ED arrival (area under the curve (AUC) = 0.85). Addition of arterial blood gas parameters (oxygen and carbon dioxide partial pressures (PO2 and PCO2)) and pH) did not improve the model. The same variables were predictors of death at 1 month (AUC = 0.85). Compared with other commonly used tools for predicting the severity of COPD in stable patients, our rule was significantly better. Conclusions: Five clinical predictors easily available in the ED, and also in the primary care setting, can be used to create a simple and easily obtained score that allows clinicians to stratify patients with eCOPD upon ED arrival and guide the medical decision-making process. This work was supported in part by grants from the Fondo de Investigacion Sanitaria (PI 06\1010, PI06\1017, PI06\714, PI06\0326, PI06\0664); Department of Health of the Basque Country, Department of Education, Universities and Research of the Basque Government (UE09/62); the Research Committee of the Hospital Galdakao; and the thematic networks-Red IRYSS (Investigacion en Resultados y Servicios Sanitarios (G03/220))- of the Instituto de Salud Carlos III.

Published
2014

47. Evolution in microbiological results in food samples in a health area in the Community of Madrid, Spain (1999-2002)

Author

Fernández de Larrea Baz, Nerea, Pérez Rodríguez, Pilar, Martín Pérez, Amalia, Mañas Urbón, Julio J., Fouz Uguet, Francisco J., García Caballero, Juan, Ordóñez Iriarte, Jose Mª, Fernández de Larrea Baz, Nerea, Pérez Rodríguez, Pilar, Martín Pérez, Amalia, Mañas Urbón, Julio J., Fouz Uguet, Francisco J., García Caballero, Juan, and Ordóñez Iriarte, Jose Mª

Abstract

Introduction: In the context of the increasing relevance of food security in the field of the Public Health, the present article try to evaluate the degree of microbiological contamination in foodstuffs, and to search improvement measures.Methods: Retrospective analysis of the results obtained from the samples of foodstuffs from industries and restauration establishements in the district 1 of the Area V of Madrid Autonomous Region between 1999 and 2002.To check the official minutes of inspections of social restauration establishements.Descriptive analysis of the data obtained.Results: The parameters in 116 of the 383 analysed samples (30 ́3%) were higher than permitted by law. The percentage of correct samples in the collective lunchrooms went up from 62% in 1999 to 89 ́9% in 2001 (p<0 ́05).The 32 ́8% of the altered samples were caused by the presence of patogens.The foodsttufs with higher percentage of alteration were the dairy products, followed by the sausages. In the cooked foods, the percentage of alteration was higher in those of group A.The primary deficiences in the social restauration establishements were the absence of non-manual accion tap, the lack of bleach suitable for alimentary use and the inadequate protection of foods.Conclusions: In collective lunchrooms we can observe an improvement in the microbiological results; however, there are still structural and process deficiencies. The results of the other industries cannot be easily assessed due to scarcity of samples.To use bleach suitable for alimentary use in a routine way, can be a measure to reduce the high percentage of group A contaminated foodstuffs., Introducción: En el marco de una creciente relevancia de la seguridad alimentaria en el ámbito de la salud pública, el presente estudio trata de valorar el grado de contaminación microbiológica de los alimentos y proponer medidas de mejora.Metodología: Análisis retrospectivo de los resultados microbiológicos de las muestras tomadas de alimentos de industrias elaboradoras y de restauración del Distrito 1 del Área V de Salud de la Comunidad de Madrid en 1999, 2000, 2001 y 2002.Revisión de las actas de inspección de los establecimientos de restauración social.Análisis descriptivo de los mismos.Resultados: De las 383 muestras analizadas, 116 (30 ́3%) superaron los límites microbiológicos permitidos por la legislación.El porcentaje de muestras correctas en comedores colectivos aumentó del 62% en 1999 al 89 ́9% en 2001 (p<0 ́05).El 32 ́8% de las muestras incorrectas lo fueron por la presencia de patógenos.Los alimentos con mayor porcentaje de incumplimiento fueron los productos lácteos, seguidos de los embutidos. En platos elaborados, el porcentaje de incumplimiento fue mayor en los del grupo A.Las principales deficiencias en los establecimientos de restauración social fueron la ausencia de lavamanos de accionamiento no manual utilizables, ausencia de lejía de uso alimentario e inadecuada protección de los alimentos.Conclusiones: Tendencia positiva en los resultados microbiológicos en comedores colectivos, aunque persisten deficiencias tanto estructurales como de proceso. En el resto de programas los resultados son menos valorables debido al bajo número de muestras.Conseguir una mayor utilización de lejía de uso alimentario podría disminuir el porcentaje de alimentos del grupo A que superan los límites microbiológicos permitidos.

Published
2004

48. Burden of disease due to cancer in Spain

Author

Fernández de Larrea-Baz, Nerea, primary, Álvarez-Martín, Elena, additional, Morant-Ginestar, Consuelo, additional, Gènova-Maleras, Ricard, additional, Gil, Ángel, additional, Pérez-Gómez, Beatriz, additional, and López-Abente, Gonzalo, additional

Published
2009
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49. Levels and determinants of urinary cadmium in general population in Spain: Metal-MCC-Spain study.

Author

Blanco Muñoz, Julia, Lope, Virginia, Fernández de Larrea-Baz, Nerea, Gómez-Ariza, José Luis, Dierssen-Sotos, Trinidad, Fernández-Tardón, Guillermo, Aragonés, Nuria, Amiano, Pilar, Gómez-Acebo, Inés, Tardón, Adonina, Grau-Pérez, María, García-Barrera, Tamara, Kogevinas, Manolis, Pollán, Marina, and Pérez-Gómez, Beatriz

Subjects
*PASSIVE smoking, *CADMIUM, *SMOKING, *CIGARETTE smoke, *SOCIODEMOGRAPHIC factors, *LOG-linear models
Abstract

Cadmium is a ubiquitous and persistent metal, associated with different harmful health effects and with increased morbidity and mortality. Understanding the main sources of exposure is essential to identify at risk populations and to design public health interventions. To evaluate cadmium exposure in a random-sample of general adult population from three regions of Spain, assessed by the urinary cadmium (U–Cd) concentration, and to identify its potential determinants and sex-specific differences, including sociodemographic, lifestyle and dietary factors. We measured U–Cd (μg/g creatinine) in single urine spot samples from 1282 controls enrolled in the multicase-control study in common tumors in Spain (MCC-Spain) with inductively coupling plasma-mass spectrometry equipped with an octopole reaction systems (ICP-ORS-MS). The association between sociodemographic, lifestyle, and dietary characteristics and U–Cd concentrations was evaluated using geometric mean ratios (GMR) estimated by multiple log-linear regression models. Overall, geometric mean U–Cd concentration was 0.40 (95%CI: 0.38, 0.41) μg/g creatinine. Levels were higher in women than in men (GMR]: 1.19; 95%CI: 1.07, 1.32), and increased with age in males (p trend < 0.001). Cigarette smoking was clearly associated to U–Cd levels (GMR former vs non-smokers : 1.16; 95%CI: 1.05, 1.29; GMR current vs non-smokers : 1.42; 95%CI: 1.26, 1.60); the relationship with secondhand tobacco exposure in non-smokers, was restricted to women (p interaction = 0.02). Sampling season and region also seemed to influence U–Cd concentrations, with lower levels in summer (GMR summer vs average : 0.79; 95%CI: 0.71, 0.88), and higher levels in North-Spain Asturias (GMR Asturias vs average : 1.13; 95%CI: 1.04, 1.23). Regarding diet, higher U–Cd concentration was associated with eggs consumption only in men (p interaction = 0.04), just as rice intake was associated in women (p interaction = 0.03). Conclusion : These results confirmed that tobacco exposure is the main modifiable predictor of U–Cd concentrations, and remark that the role of dietary/sociodemographic factors on U–Cd levels may differ by sex. • Smoking status is the main modifiable predictor of U-Cd concentrations. • Secondhand smoke exposure could be an important source of cadmium exposure in women. • Dietary variables explain a small proportion of total variation in U-Cd levels. • Regional/seasonal differences in U-Cd levels suggest environmental factors involved. [ABSTRACT FROM AUTHOR]

Published
2022
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50. Socio-geographical disparities of obesity and excess weight in adults in Spain: insights from the ENE-COVID study.

Author

Gutiérrez-González E, García-Solano M, Pastor-Barriuso R, Fernández de Larrea-Baz N, Rollán-Gordo A, Peñalver-Argüeso B, Peña-Rey I, Pollán M, and Pérez-Gómez B

Subjects
Humans, Adult, Male, Female, Socioeconomic Factors, Spain epidemiology, Obesity epidemiology, Overweight epidemiology, COVID-19 epidemiology
Abstract

Background: In Spain, differences in the prevalence of obesity and excess weight according to sex and sociodemographic factors have been described at the national level, although current data do not allow to delve into geographical differences for these conditions. The aim was to estimate national and regional prevalences of adult obesity and excess weight in Spain by sex and sociodemographic characteristics, and to explore difference sources of inequalities in its distribution, as well as its geographical pattern., Method: ENE-COVID study was a nationwide representative seroepidemiological survey with 57,131 participants. Residents in 35,893 households were selected from municipal rolls using a two-stage random sampling stratified by province and municipality size (April-June 2020). Participants (77.0% of contacted individuals) answered a questionnaire which collected self-reported weight and height, as well as different socioeconomic variables, that allowed estimating crude and standardized prevalences of adult obesity and excess weight., Results: Crude prevalences of obesity and excess weight were higher in men (obesity: 19.3% vs. 18.0%; excess weight: 63.7% vs. 48.4%), while severe obesity was more prevalent in women (4.5% vs. 5.3%). These prevalences increased with age and disability, and decreased with education, census tract income and municipality size. Differences by educational level, relative census income, nationality or disability were clearly higher among women. Obesity by province ranged 13.3-27.4% in men and 11.4-28.1% in women; excess weight ranged 57.2-76.0% in men and 38.9-59.5% in women. The highest prevalences were located in the southern half of the country and some north-western provinces. Sociodemographic characteristics only explained a small part of the observed geographical variability (25.2% obesity)., Conclusion: Obesity and overweight have a high prevalence in Spain, with notable geographical and sex differences. Socioeconomic inequalities are stronger among women. The observed geographical variability suggests the need to implement regional and local interventions to effectively address this public health problem., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Gutiérrez-González, García-Solano, Pastor-Barriuso, Fernández de Larrea-Baz, Rollán-Gordo, Peñalver-Argüeso, Peña-Rey, Pollán, Pérez-Gómez and the ENE-COVID Study Group.)

Published
2023
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