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Your search keyword '"Galimberti, Viviana E."' showing total 9 results
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9 results on '"Galimberti, Viviana E."'

1. Immune microenvironment dynamics in breast cancer during pregnancy: impact of gestational age on tumor-infiltrating lymphocytes and prognosis

Author

Sajjadi, Elham, primary, Venetis, Konstantinos, additional, Ivanova, Mariia, additional, Noale, Marianna, additional, Blundo, Concetta, additional, Di Loreto, Eugenia, additional, Scarfone, Giovanna, additional, Ferrero, Stefano, additional, Maggi, Stefania, additional, Veronesi, Paolo, additional, Galimberti, Viviana E., additional, Viale, Giuseppe, additional, Peccatori, Fedro A., additional, Fusco, Nicola, additional, and Guerini-Rocco, Elena, additional

Published
2023
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2. Breast Cancer during Pregnancy as a Special Type of Early-Onset Breast Cancer: Analysis of the Tumor Immune Microenvironment and Risk Profiles

Author

Sajjadi, Elham, primary, Venetis, Konstantinos, additional, Noale, Marianna, additional, Azim, Hatem A., additional, Blundo, Concetta, additional, Bonizzi, Giuseppina, additional, Di Loreto, Eugenia, additional, Scarfone, Giovanna, additional, Ferrero, Stefano, additional, Maggi, Stefania, additional, Barberis, Massimo, additional, Veronesi, Paolo, additional, Galimberti, Viviana E., additional, Viale, Giuseppe, additional, Fusco, Nicola, additional, Peccatori, Fedro A., additional, and Guerini-Rocco, Elena, additional

Published
2022
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3. Abstract P3-18-08: Feasibility and safety of breast-conserving surgery in early-stage breast cancers during the first trimester of pregnancy

Author

Fusco, Nicola, primary, Blundo, Concetta, additional, Giroda, Massimo, additional, Sajjadi, Elham, additional, Venetis, Konstantinos, additional, Leonardi, M. Cristina, additional, Vicini, Elisa, additional, Despini, Luca, additional, Rossi, Claudia F., additional, Runza, Letterio, additional, Di Loreto, Eugenia, additional, Scarfone, Giovanna, additional, Guerini-Rocco, Elena, additional, Viale, Giuseppe, additional, Veronesi, Paolo, additional, Buonomo, Barbara, additional, Peccatori, Fedro A., additional, and Galimberti, Viviana E., additional

Published
2022
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4. Abstract P4-07-02: Tumor microenvironment characteristics and prognosis in breast cancer during pregnancy: The role of differentially expressed immune-related genes

Author

Fusco, Nicola, primary, Sajjadi, Elham, additional, Venetis, Konstantinos, additional, Buonomo, Barbara, additional, Blundo, Concetta, additional, Giroda, Massimo, additional, Loreto, Eugenia Di, additional, Scarfone, Giovanna, additional, Ferrero, Stefano, additional, Veronesi, Paolo, additional, Galimberti, Viviana E., additional, Barberis, Massimo, additional, Viale, Giuseppe, additional, Guerini-Rocco, Elena, additional, and Peccatori, Fedro A., additional

Published
2022
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5. Early Breast Cancers During Pregnancy Treated With Breast-Conserving Surgery in the First Trimester of Gestation: A Feasibility Study

Author

Blundo, Concetta, primary, Giroda, Massimo, additional, Fusco, Nicola, additional, Sajjadi, Elham, additional, Venetis, Konstantinos, additional, Leonardi, M. Cristina, additional, Vicini, Elisa, additional, Despini, Luca, additional, Rossi, Claudia F., additional, Runza, Letterio, additional, Sfondrini, Maria S., additional, Piciotti, Roberto, additional, Di Loreto, Eugenia, additional, Scarfone, Giovanna, additional, Guerini-Rocco, Elena, additional, Viale, Giuseppe, additional, Veronesi, Paolo, additional, Buonomo, Barbara, additional, Peccatori, Fedro A., additional, and Galimberti, Viviana E., additional

Published
2021
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6. Abstract P2-05-03: Integrated analysis of mismatch repair, PD-L1, and immune microenvironment status in pregnancy-associated breast cancers

Author

Fusco, Nicola, primary, Guerini-Rocco, Elena, additional, Buonomo, Barbara, additional, Croci, Roberto, additional, Fumagalli, Caterina, additional, Lopez, Gianluca, additional, Croci, Giorgio A, additional, Runza, Letterio, additional, Sajjadi, Elham, additional, Blundo, Concetta, additional, Despini, Luca, additional, Giroda, Massimo, additional, Galimberti, Viviana E, additional, Veronesi, Paolo, additional, Barberis, Massimo, additional, Ferrero, Stefano, additional, Scarfone, Giovanna, additional, Bosari, Silvano, additional, Viale, Giuseppe, additional, and Peccatori, Fedro, additional

Published
2020
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7. Autophagy regulates UBC9 levels during viral-mediated tumorigenesis

Author

Mattoscio, Domenico, primary, Casadio, Chiara, additional, Miccolo, Claudia, additional, Maffini, Fausto, additional, Raimondi, Andrea, additional, Tacchetti, Carlo, additional, Gheit, Tarik, additional, Tagliabue, Marta, additional, Galimberti, Viviana E., additional, De Lorenzi, Francesca, additional, Pawlita, Michael, additional, Chiesa, Fausto, additional, Ansarin, Mohssen, additional, Tommasino, Massimo, additional, and Chiocca, Susanna, additional

Published
2017
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8. Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer

Author

Chiaradonna, Ferdinando, primary, Barozzi, Iros, additional, Miccolo, Claudia, additional, Bucci, Gabriele, additional, Palorini, Roberta, additional, Fornasari, Lorenzo, additional, Botrugno, Oronza A., additional, Pruneri, Giancarlo, additional, Masullo, Michele, additional, Passafaro, Alfonso, additional, Galimberti, Viviana E., additional, Fantin, Valeria R., additional, Richon, Victoria M., additional, Pece, Salvatore, additional, Viale, Giuseppe, additional, Di Fiore, Pier Paolo, additional, Draetta, Giulio, additional, Pelicci, Pier Giuseppe, additional, Minucci, Saverio, additional, and Chiocca, Susanna, additional

Published
2015
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9. Autophagy regulates UBC9 levels during viral-mediated tumorigenesis

Author

Fausto Chiesa, Susanna Chiocca, Carlo Tacchetti, Michael Pawlita, Fausto Maffini, Claudia Miccolo, Massimo Tommasino, Marta Tagliabue, Chiara Casadio, Domenico Mattoscio, Andrea Raimondi, Mohssen Ansarin, Francesca De Lorenzi, Viviana Galimberti, Tarik Gheit, Mattoscio, Domenico, Casadio, Chiara, Miccolo, Claudia, Maffini, Fausto, Raimondi, Andrea, Tacchetti, Carlo, Gheit, Tarik, Tagliabue, Marta, Galimberti, Viviana E., De Lorenzi, Francesca, Pawlita, Michael, Chiesa, Fausto, Ansarin, Mohssen, Tommasino, Massimo, and Chiocca, Susanna

Subjects
0301 basic medicine, Oncogene Proteins, Carcinogenesis, SUMO protein, Regulator, Apoptosis, Pathology and Laboratory Medicine, medicine.disease_cause, Cell Transformation, Biochemistry, Polymerase Chain Reaction, Transduction (genetics), 0302 clinical medicine, Transduction, Genetic, Medicine and Health Sciences, Small interfering RNAs, Viral, Papillomaviridae, lcsh:QH301-705.5, Microscopy, Microscopy, Confocal, Cell Death, Transfection, Flow Cytometry, Immunohistochemistry, SUMOylation, Cell biology, Nucleic acids, Cell Transformation, Neoplastic, Oncology, Medical Microbiology, Cell Processes, Viral Pathogens, 030220 oncology & carcinogenesis, Confocal, Viruses, Female, Post-translational modification, Pathogens, Cellular Structures and Organelles, Research Article, Human, lcsh:Immunologic diseases. Allergy, Papillomaviruses, Autophagic Cell Death, Immunoblotting, Immunology, Biology, Research and Analysis Methods, Microbiology, HPV-16, 03 medical and health sciences, Transduction, Ubiquitin-Conjugating Enzyme, Autophagy, Cell Transformation, Viral, Humans, Oncogene Proteins, Viral, Papillomavirus Infections, Ubiquitin-Conjugating Enzymes, Parasitology, Molecular Biology, Genetics, Virology, Genetic, medicine, Non-coding RNA, Microbial Pathogens, Immunohistochemistry Techniques, Papillomavirus Infection, Neoplastic, Biology and life sciences, Organisms, Proteins, Apoptosi, Cell Biology, biology.organism_classification, Gene regulation, Histochemistry and Cytochemistry Techniques, 030104 developmental biology, lcsh:Biology (General), Immunologic Techniques, RNA, Gene expression, DNA viruses, Lysosomes, lcsh:RC581-607
Abstract

UBC9, the sole E2-conjugating enzyme required for SUMOylation, is a key regulator of essential cellular functions and, as such, is frequently altered in cancers. Along these lines, we recently reported that its expression gradually increases during early stages of human papillomavirus (HPV)-mediated cervical lesions transformation. However, a better understanding of how UBC9 is exploited by transforming viral oncoproteins is still needed. In the present study, we show that in human samples HPV drives UBC9 up-regulation also in very early steps of head and neck tumorigenesis, pointing to the important role for UBC9 in the HPV-mediated carcinogenic program. Moreover, using HPV-infected pre-cancerous tissues and primary human keratinocytes as the natural host of the virus, we investigate the pathological meaning and the cellular mechanisms responsible for UBC9 de-regulation in an oncoviral context. Our results show that UBC9 overexpression is promoted by transforming viral proteins to increase host cells’ resistance to apoptosis. In addition, ultrastuctural, pharmacological and genetic approaches crucially unveil that UBC9 is physiologically targeted by autophagy in human cells. However, the presence of HPV E6/E7 oncoproteins negatively impacts the autophagic process through selective inhibition of autophagosome-lysosome fusion, finally leading to p53 dependent UBC9 accumulation during viral-induced cellular transformation. Therefore, our study elucidates how UBC9 is manipulated by HPV oncoproteins, details the physiological mechanism by which UBC9 is degraded in cells, and identifies how HPV E6/E7 impact on autophagy. These findings point to UBC9 and autophagy as novel hallmarks of HPV oncogenesis, and open innovative avenues towards the treatment of HPV-related malignancies., Author summary High risk HPV is the primary cause of cervical cancer and in recent years a clear role for the virus in other anogenital malignancies, in head and neck and in nonmelanoma skin cancers is emerging. Cellular transformation is mediated by the viral oncoproteins E6 and E7 that have the ability to target several pathways. We recently demonstrated that UBC9, the key enzyme of the Small Ubiquitin-like Modifier (SUMO) pathway, is up-regulated during pre-cancerous and cancerous stages of cervical carcinogenesis. In this study, we elucidate the pathological impact and the cellular mechanisms responsible for UBC9 accumulation promoted by HPV in cervical and head and neck pre-cancerous tissues. Indeed, we show that UBC9 is physiologically degraded in cells by autophagy, and that the expression of HPV oncoproteins impairs autophagy finally leading to UBC9 accumulation and apoptosis resistance of infected cells. Our results therefore identify UBC9 and autophagy as important co-factors to prime early stages of HPV-mediated tumorigenesis, and pinpoint novel therapeutic strategies for treatment of carcinogenic HPV infections.

Published
2017

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