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Your search keyword '"Geng, Xiuqin"' showing total 15 results
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15 results on '"Geng, Xiuqin"'

8. miR-708-5p promotes fibroblast-like synoviocytes’ cell apoptosis and ameliorates rheumatoid arthritis by the inhibition of Wnt3a/β-catenin pathway

Author

Wu, Jie, Fan, Wenqiang, Ma, Ling, and Geng, Xiuqin

Subjects
rheumatoid arthritis, Male, Apoptosis, Genetic Therapy, miR-708-5p, Synoviocytes, Cell Line, Rats, Arthritis, Rheumatoid, Rats, Sprague-Dawley, Wnt, Disease Models, Animal, MicroRNAs, cell proliferation, Cell Movement, Wnt3A Protein, Animals, Humans, Collagen Type II, beta Catenin, Original Research
Abstract

Aim MicroRNAs (miRNA) are a class of small, highly conserved noncoding RNA molecules, which contain 18–28 nucleotides and are involved in the regulation of gene expression. It has been proved that microRNAs play a very important role in several key cellular processes, such as cell differentiation, cell cycle progression, and apoptosis, as well as in autoimmune disease. One recently identified miRNA, miR-708-5p, has been demonstrated to have profound roles in suppressing oncogenesis in different types of tumors. However, the role of miR-708-5p in rheumatoid arthritis (RA) remains to be fully elucidated. Therefore, in this study, we are aiming to identify the role of miR-708-5p in RA. Methods The expression level of miR-708-5p in synovial tissues of patients with RA is much lower than in non-RA controls. The effects of miR-708-5p on cell apoptosis, colony formation, and migration in fibroblast-like synoviocytes were assessed in MH7A cells. Results Results showed that delivery of miR-708-5p mimics into synovial fibroblasts MH7A could induce cell apoptosis and inhibit colony formation and migration. In addition, miR-708-5p mimics significantly inhibit Wnt3a/β-catenin pathway activity both in transcription and protein level, which could be reversed by the addition of R-spondin 1, an activator of Wnt pathway. R-spondin 1 could also reverse the inhibition of cell survival and proliferation, which was induced by miR-708-5p mimics in MH7A. Moreover, injection of miR-708-5p mimics into collagen-induced rat RA model could ameliorate the RA index and decrease Wnt3a/β-catenin expression in rat joint tissues. Conclusion Therefore, we concluded that miR-708-5p is likely to be involved in RA pathogenesis via inhibition of Wnt3a/β-catenin pathway.

Published
2018

14. Effect of drugs, iodine 131, and surgery on bone mineral density and bone turnover markers in hyperthyroid patients.

Author

DONG Jianzhou, FENG Yaoqing, SUI Hua, GENG Xiuqin, ZHOU Yanhong, LI Jiangyan, and ZHAO Jianlin

Abstract

Objective To evaluate the impact of drug therapy, radioiodine therapy, and surgical therapy in bone mineral density and biochemical bone turnover markers in patients with hyperthyroidism. Methods A total of 186 female patients with hyperthyroidism were enrolled in the study. They received drug therapy, radioiodine therapy, or surgical therapy according to the disease course and their own wish. Bone mineral density and biochemical bone turnover markers were compared at the time of enrollment and after 2-year treatment. Results Bone mineral density increased and biochemical bone turnover markers decreased significantly in all patients in 3 groups. No difference between bone mineral density and bone turnover markers were found among the 3 groups. Conclusion Drug therapy, radioiodine therapy, and surgical therapy improve bone mineral density and decrease biochemical markers of bone turnover in hyperthyroid patients. [ABSTRACT FROM AUTHOR]

Published
2015
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15. Effect of long-term small dose of methimazole and radioiodine 131 on bone mineral density, cardiac function, and biochemical indexes during the treatment of recurrent hyperthyroidism.

Author

SUI Hua, GENG Xiuqin, and ZHOU Yanhong

Subjects
*BONE densitometry, *HEART function tests, *HYPERTHYROIDISM, *LIPOPROTEINS, *PATIENTS, THERAPEUTIC use of iodine isotopes
Abstract

Objective To compare the effect of long-term small dose of methimazole or radioiodine 131 on bone mineral density (BMD), cardiac function, and biochemical indexes in patients with recurrent hyperthyroidism. Methods Sixty-two patients with recurrent hyperthyroidism were randomly divided into two groups: drug treatment group and radioiodine treatment group. Twenty-eight patients took a long-term oral medication of methimazole, while 34 patients were given a radioiodine treatment. During the follow-up, the thyroid function, serum lipids and lipoproteins, echocardiography, and BMD were detected. Results The thyroid function of 28 patients in drug treatment group and 13 patients in radioiodine treatment group was normal, while the other 21 patients in radioiodine treatment group had hypothyroidism. The serum levels of lipids in drug treatment group were much lower than that in radioiodine treatment group, while no difference of BMD, white blood cell, liver function, and cardiac function was observed between the two groups. Conclusion Compared with radioiodine treatment, long-term small dose of methimazole treatment is safe for patients with recurrent hyperthyroidism. [ABSTRACT FROM AUTHOR]

Published
2014
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