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Your search keyword '"Guo Hao Ma"' showing total 5 results
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5 results on '"Guo Hao Ma"'

1. Anti-inflammatory principles from Lindera aggregata

Author

Sio Hong Lam, Ping Chung Kuo, Liang Mou Kuo, Daih Huang Kuo, Tian Shung Wu, Hsin Yi Hung, Yi Hung Wu, Tsong-Long Hwang, and Guo Hao Ma

Subjects
Neutrophils, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Sesquiterpene, 01 natural sciences, Biochemistry, Anti-inflammatory, Lindera aggregata, chemistry.chemical_compound, Superoxides, Drug Discovery, medicine, Ic50 values, Humans, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Pancreatic Elastase, biology, 010405 organic chemistry, Superoxide, Alkaloid, Organic Chemistry, Glycoside, biology.organism_classification, Lindera, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry, Natural source, Molecular Medicine, Sesquiterpenes
Abstract

Four new sesquiterpenes (1–4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC50 values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

Published
2020
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2. New Benzenoids from the Roots of Lindera aggregata

Author

Guo-Hao, Ma, Che-Weii, Lin, Hsin-Yi, Hung, Sheng-Yang, Wang, Po-Chuen, Shieh, and Tian-Shung, Wu

Subjects
Molecular Structure, Phenols, Benzene Derivatives, Lindera, Plant Roots
Abstract

Two new benzenoids, linderagatin A and B (1-2), were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of 1D (1H, 13C) and 2D NMR (COSY, NOESY, HSQC and HMBC) spectra. Moreover, their absolute configurations were established from ECD spectra compared with previous reports.

Published
2016

3. Synthesis and structural characterization of an anti-inflammatory principle purified from Lindera aggregata

Author

Yue-Chiun Li, Guo-Hao Ma, E-Jian Lee, Tsong-Long Hwang, Tian Shung Wu, Mei-Lin Yang, and Ping Chung Kuo

Subjects
Lindera, Chemical transformation, biology, Stereochemistry, Superoxide, medicine.drug_class, Chemical structure, Organic Chemistry, Elastase, biology.organism_classification, Biochemistry, Anti-inflammatory, Lindera aggregata, chemistry.chemical_compound, chemistry, Drug Discovery, medicine, Cytochalasin B
Abstract

Linderaggrine A (1) was characterized from the roots of Lindera aggregata and its chemical structure was established by the spectral analysis and chemical transformation. The chemical preparation of 1 and its isomer 2 provide unambiguous evidences for the structural determination of the naturally isolated compound. In addition, the inhibition of superoxide anion generation and elastase release by human neutrophils in response to FMLP/cytochalasin B of these synthetic products had been examined and among the tested compounds, linderaggrine A (1) displayed significant potential against the superoxide anion generation.

Published
2014
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4. ChemInform Abstract: Synthesis and Structural Characterization of an Antiinflammatory Principle Purified from Lindera aggregata

Author

Ping Chung Kuo, Mei-Lin Yang, Tsong‐Long Hwang, Yue‐Chiun Li, Tian Shung Wu, E-Jian Lee, and Guo-Hao Ma

Subjects
chemistry.chemical_compound, chemistry, biology, Superoxide, Stereochemistry, General Medicine, biology.organism_classification, Lindera aggregata
Abstract

Linderaggrine A (I) exhibits significant inhibitory effects against the superoxide anion generation.

Published
2014
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5. New Benzenoids from the Roots of Lindera aggregata

Author

Tian Shung Wu, Guo Hao Ma, Hsin Yi Hung, Sheng-Yang Wang, Che Wei Lin, and Po Chuen Shieh

Subjects
Pharmacology, Lindera, Plant roots, biology, Stereochemistry, Chemistry, Plant Science, General Medicine, Nuclear magnetic resonance spectroscopy, biology.organism_classification, Lindera aggregata, Complementary and alternative medicine, Drug Discovery, Benzene derivatives, Botany, Two-dimensional nuclear magnetic resonance spectroscopy
Abstract

Two new benzenoids, linderagatin A and B (1–2), were isolated from the roots of Lindera aggregata. Their structures were elucidated on the basis of 1D (1H, 13C) and 2D NMR (COSY, NOESY, HSQC and HMBC) spectra. Moreover, their absolute configurations were established from ECD spectra compared with previous reports.

Published
2015
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