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554 results on '"Gupta, Ruby"'

2. ER calcium depletion as a key driver for impaired ER-to-mitochondria calcium transfer and mitochondrial dysfunction in Wolfram syndrome

Author

Liiv, Mailis, Vaarmann, Annika, Safiulina, Dzhamilja, Choubey, Vinay, Gupta, Ruby, Kuum, Malle, Janickova, Lucia, Hodurova, Zuzana, Cagalinec, Michal, Zeb, Akbar, Hickey, Miriam A., Huang, Yi-Long, Gogichaishvili, Nana, Mandel, Merle, Plaas, Mario, Vasar, Eero, Loncke, Jens, Vervliet, Tim, Tsai, Ting-Fen, Bultynck, Geert, Veksler, Vladimir, and Kaasik, Allen

Published
2024
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28. Prevalence of chronic kidney disease and risk factors for its progression: A cross-sectional comparison of Indians living in Indian versus U.S. cities

Author

Anand, Shuchi, Kondal, Dimple, Montez-Rath, Maria, Zheng, Yuanchao, Shivashankar, Roopa, Singh, Kalpana, Gupta, Priti, Gupta, Ruby, Ajay, Vamadevan S, Mohan, Viswanathan, Pradeepa, Rajendra, Tandon, Nikhil, Ali, Mohammed K, Narayan, KM Venkat, Chertow, Glenn M, Kandula, Namratha, Prabhakaran, Dorairaj, and Kanaya, Alka M

Subjects
Biomedical and Clinical Sciences, Public Health, Health Sciences, Diabetes, Nutrition, Clinical Research, Cardiovascular, Kidney Disease, Metabolic and endocrine, Renal and urogenital, Adult, Aged, Cross-Sectional Studies, Disease Progression, Female, Humans, India, Kidney Failure, Chronic, Male, Middle Aged, Prevalence, Risk Factors, United States, General Science & Technology
Abstract

BackgroundWhile data from the latter part of the twentieth century consistently showed that immigrants to high-income countries faced higher cardio-metabolic risk than their counterparts in low- and middle-income countries, urbanization and associated lifestyle changes may be changing these patterns, even for conditions considered to be advanced manifestations of cardio-metabolic disease (e.g., chronic kidney disease [CKD]).Methods and findingsUsing cross-sectional data from the Center for cArdiometabolic Risk Reduction in South Asia (CARRS, n = 5294) and Mediators of Atherosclerosis in South Asians Living in America (MASALA, n = 748) studies, we investigated whether prevalence of CKD is similar among Indians living in Indian and U.S. cities. We compared crude, age-, waist-to-height ratio-, and diabetes- adjusted CKD prevalence difference. Among participants identified to have CKD, we compared management of risk factors for its progression. Overall age-adjusted prevalence of CKD was similar in MASALA (14.0% [95% CI 11.8-16.3]) compared with CARRS (10.8% [95% CI 10.0-11.6]). Among men the prevalence difference was low (prevalence difference 1.8 [95% CI -1.6,5.3]) and remained low after adjustment for age, waist-to-height ratio, and diabetes status (-0.4 [-3.2,2.5]). Adjusted prevalence difference was higher among women (prevalence difference 8.9 [4.8,12.9]), but driven entirely by a higher prevalence of albuminuria among women in MASALA. Severity of CKD--i.e., degree of albuminuria and proportion of participants with reduced glomerular filtration fraction--was higher in CARRS for both men and women. Fewer participants with CKD in CARRS were effectively treated. 4% of CARRS versus 51% of MASALA participants with CKD had A1c < 7%; and 7% of CARRS versus 59% of MASALA participants blood pressure < 140/90 mmHg. Our analysis applies only to urban populations. Demographic--particularly educational attainment--differences among participants in the two studies are a potential source of bias.ConclusionsPrevalence of CKD among Indians living in Indian and U.S. cities is similar. Persons with CKD living in Indian cities face higher likelihood of experiencing end-stage renal disease since they have more severe kidney disease and little evidence of risk factor management.

Published
2017

34. Theoretical Study on Weibel instability in the existence of large amplitude Langmuir wave inside a Plasma

Author

Kumar Amit, Dhawan Rajat, Gupta Ruby, Sabharwal Namita, and Sharma Jyotsna

Subjects
Environmental sciences, GE1-350
Abstract

This paper investigates how an electrostatic Langmuir wave having large amplitude affects the Weibel instability (WI) in the existence of ions and an electron beam. Two Langmuir side band waves are produced by coupling of EM perturbation to the Langmuir wave. The Langmuir wave (LW) increases the growth rate beyond its linear value. Here, we noticed that the growth rate Γ(sec−1) scales linearly with the electron beam velocity vbe and 1/2 power of the electron beam density nbe. As we increase the density of ions inside the plasma, the growth rate stabilizes. Additionally, we find that the growth rate is very sensitive to the plasma frequency of ions. Therefore, our work finds an application in space, galactic cosmic rays and supernovas. Also, our work covers a range of application from the development of fusion power to understand the various astrophysical phenomena.

Published
2023
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38. Effect of Yoga-Based Cardiac Rehabilitation Program on Endothelial Function, Oxidative Stress, and Inflammatory Markers in Acute Myocardial Infarction: A Randomized Controlled Trial

Author

Patil, Satish Gurunathrao, primary, Sobitharaj, Edmin Christa, additional, Chandrasekaran, Ambalam Mahendrakumar, additional, Patil, Shankar S., additional, Singh, Kalpana, additional, Gupta, Ruby, additional, Deepak, Kishore Kumar, additional, Jaryal, Ashok Kumar, additional, Chandran, Dinu Santha, additional, Kinra, Sanjay, additional, Roy, Ambuj, additional, and Prabhakaran, Dorairaj, additional

Published
2024
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48. Docosahexaenoic acid supplementation in lactating women increases breast milk and erythrocyte membrane docosahexaenoic acid concentrations and alters infant n-6: n-3 fatty acid ratio

Author

Khandelwal, Shweta, primary, Kondal, Dimple, additional, Gupta, Ruby, additional, Chaudhry, Monica, additional, Dutta, Soumam, additional, Ramakrishnan, Lakshmy, additional, Patil, Kamal, additional, Swamy, M.K., additional, Prabhakaran, Dorairaj, additional, Tandon, Nikhil, additional, Ramakrishnan, Usha, additional, and Stein, Aryeh D., additional

Published
2023
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49. Enhancing Magnetic Hyperthermia Efficacy through Targeted Heat Shock Protein 90 Inhibition: Unveiling Immune-Mediated Therapeutic Synergy in Glioma Treatment

Author

Gupta, Ruby, Chauhan, Anjali, Kaur, Tashmeen, Kuanr, Bijoy Kumar, and Sharma, Deepika

Abstract

The induction of heat stress response (HSR) mediated by the generation of heat shock proteins (HSPs) on exposure to magnetic hyperthermia-mediated cancer therapy (MHCT) decreases the efficacy of localized heat treatment at the tumor site, and thus therapy remains a significant challenge. Hence, the present study examined differential HSR elicited in glioma cells post-MHCT under different tumor microenvironment conditions (2D monolayers, 3D monoculture, and coculture spheroids) to recognize target genes that, when downregulated, could enhance the therapeutic effect of MHCT. Gene expression analysis following MHCT revealed that HSP90 was upregulated as compared to HSP70. Hence, to enhance the efficacy of the treatment, a combinatorial strategy using 17-DMAG as an inhibitor of HSP90 following MHCT was investigated. The effects of combinatorial therapy in terms of cell viability, HSP levels by immunofluorescence and gene expression analysis, oxidative stress generation, and alterations in cellular integrity were evaluated, where combinatorial therapy demonstrated an enhanced therapeutic outcome with maximum glioma cell death. Further, in the murine glioma model, a rapid tumor inhibition of 65 and 53% was observed within 8 days at the primary and secondary tumor sites, respectively, in the MCHT + 17-DMAG group, with abscopal effect-mediated complete tumor inhibition at both the tumor sites within 20 days of MHCT. The extracellularly released HSP90 from dying tumor cells further suggested the induction of immune response supported by the upregulation of IFN-γ and calreticulin genes in the MHCT + 17-DMAG group. Overall, our findings indicate that MHCT activates host immune systems and efficiently cooperates with the HSP90 blockade to inhibit the growth of distant metastatic tumors.

Published
2024
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