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565 results on '"Haas, Marion"'

15. Translating research into practice: outcomes from the Healthy Living after Cancer partnership project

Author

Eakin, Elizabeth G., Reeves, Marina M., Goode, Ana D., Winkler, Elisabeth A. H., Vardy, Janette L., Boyle, Frances, Haas, Marion R., Hiller, Janet E., Mishra, Gita D., Jefford, Michael, Koczwara, Bogda, Saunders, Christobel M., Chapman, Kathy, Hing, Liz, Boltong, Anna G., Lane, Katherine, Baldwin, Polly, Millar, Lesley, McKiernan, Sandy, Demark-Wahnefried, Wendy, Courneya, Kerry S., Job, Jennifer, Reid, Natasha, Robson, Erin, Moretto, Nicole, Gordon, Louisa, and Hayes, Sandra C.

Published
2020
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21. How can we encourage the provision of early medical abortion in primary care? Results of a best–worst scaling survey.

Author

Haas, Marion, Church, Jody, Street, Deborah J., Bateson, Deborah, and Mazza, Danielle

Subjects
*STATISTICS, *HEALTH services accessibility, *ABORTION, *SOCIAL stigma, *PRIMARY health care, *SURVEYS, *NURSES, *DESCRIPTIVE statistics, *SOCIODEMOGRAPHIC factors, *DATA analysis, *DATA analysis software, *WOMEN'S health, *REPRODUCTIVE health
Abstract

Background: Almost one in four women in Australia experience an unintended pregnancy during their lifetime; of these, approximately 30% currently end in abortion. Although early medical abortion (EMA) up to 9 weeks gestation is becoming more widely available in Australia, it is still not commonly offered in primary care. The aim of this study was to investigate the barriers and facilitators to the provision of EMA in primary care. Methods: A sample of 150 general practitioners (GPs) and 150 registered nurses (RNs) working in Australia responded to a best–worst scaling survey designed to answer the following question: what are the most important facilitators and barriers to the provision of EMA in primary care? Results: GPs believe that the lack of clinical guidelines, the amount of information provision and counselling required, and the fact that women who are not their patients may not return for follow-up are the most important barriers. For RNs, these three barriers, together with the stigma of being known as being involved in the provision of EMA, are the most important barriers. The formation of a community of practice to support the provision of EMA was identified by both professions as the most important facilitator. Conclusions: Having access to a community of practice, enhanced training and reducing stigma will encourage the provision of EMA. Although clinical guidelines are available, they need to be effectively disseminated, implemented and endorsed by peak bodies. Primary care practices should consider using task sharing and developing patient resources to facilitate the provision of information and counselling. Although available, early medical abortion is not commonly offered in general practice. When asked, GPs and RNs reported that lack of clinical guidelines, the need to provide information and counselling, and follow-up issues were important barriers to the provision of early medical abortion, whereas having access to a community of practice was the most important facilitator. Guidelines are available, but require dissemination and implementation. Task sharing and appropriate remuneration will encourage more GPs to offer early medical abortion, so it is seen as an essential service. [ABSTRACT FROM AUTHOR]

Published
2023
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26. The preferences of women in Australia for the features of long-acting reversible contraception: results of a discrete choice experiment

Author

Haas, Marion, primary, Church, Jody, additional, Street, Deborah J., additional, Bateson, Deborah, additional, Fisher, Jane, additional, Taft, Angela, additional, Black, Kirsten I., additional, Lucke, Jayne, additional, Hussainy, Safeera Y., additional, McGeechan, Kevin, additional, Norman, Wendy, additional, and Mazza, Danielle, additional

Published
2022
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31. Pivotal role of PIM2 kinase in plasmablast generation and plasma cell survival, opening new treatment options in myeloma

Author

Haas, Marion, Caron, Gersende, Chatonnet, Fabrice, Manenti, Stephane, Alaterre, Elina, Devin, Julie, Delaloy, Céline, Bertolin, Giulia, Viel, Roselyne, Pignarre, Amandine, Llamas Gutierrez, Francisco, Marchalot, Anne, Decaux, Olivier, Tarte, Karin, Delpy, Laurent, Moreaux, Jerome, Fest, Thierry, Microenvironment, Cell Differentiation, Immunology and Cancer (MICMAC), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer (MOBIDIC), Université de Rennes (UR)-Etablissement français du sang [Rennes] (EFS Bretagne)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de génétique humaine (IGH), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université de Toulouse (UT), Institut de Génétique et Développement de Rennes (IGDR), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), H2P2 - Histo Pathologie Hight Precision (H2P2), Université de Rennes (UR)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Contrôle de la Réponse Immune B et des Lymphoproliférations (CRIBL), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST), Université de Limoges (UNILIM)-Université de Limoges (UNILIM), This work was funded by an internal grant from the Hematology Laboratory, CHU deRennes, and Région GO Ligue contre le Cancer. MH has received a doctoral fellowshipfrom FHU CAMIn, Ligue Contre le Cancer/Comité d’Ile et Vilaine. AP received a PhDfellowship from Région Bretagne and Ligue Nationale contre le Cancer.Immunofluorescence studies were performed at the Microscopy Rennes ImagingCenter (MRic-ALMF) and in the H2P2 facility, both of which are members of the UMS6480 Biosit (Rennes, France) and the French national France-BioImaginginfrastructure network funded by the French Research Agency (ANR-10-INBS-04). Cellsorting was performed at the Biosit Flow Cytometry and the CytomeTRI cell sortingfacilities (UMS6480 Biosit). We are indebted to the Centre de Ressources Biologiques(CRB)-Santé (BB-0033-00056, http://www.crbsante-rennes.com) at Rennes UniversityMedical Center for its help with processing biological samples, and we also thankseveral clinicians and patients for providing samples for research purposes. We thankthe MMRF for sharing the RNA sequencing and clinical data for patients enrolled in theCoMMpass study via the MMRF genomics portal., and ANR-10-INBS-0004,France-BioImaging,Développment d'une infrastructure française distribuée coordonnée(2010)

Subjects
[SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.CAN]Life Sciences [q-bio]/Cancer, Immunotherapy, humanities, Immunobiology
Abstract

International audience; The differentiation of B cells into plasmablasts (PBs) and then plasma cells (PCs) is associated with extensive cell reprogramming and new cell functions. By using specific inhibition strategies (including a novel morpholino RNA antisense approach), we found that early, sustained upregulation of the proviral integrations of Moloney virus 2 (PIM2) kinase is a pivotal event during human B cell in vitro differentiation and then continues in mature normal and malignant PCs in the bone marrow. In particular, PIM2 sustained the G1/S transition by acting on CDC25A and p27Kip1 and hindering caspase 3-driven apoptosis through BAD phosphorylation and cytoplasmic stabilization of p21Cip1. In PCs, interleukin-6 triggered PIM2 expression, resulting in anti-apoptotic effects on which malignant PCs were particularly dependent. In multiple myeloma, pan-PIM and MCL1 inhibitors displayed synergistic activity. Our results highlight a cell-autonomous function that links kinase activity to the PBs’ newly acquired secretion ability and the adaptability observed in both normal and malignant PCs, and finally should prompt the reconsideration of PIM2 as a therapeutic target in multiple myeloma.

Published
2022

35. Cost-Effectiveness Analysis of the New South Wales Adult Drug Court Program

Author

Shanahan, Marian, Lancsar, Emily, and Haas, Marion

Abstract

In New South Wales, Australia, a cost-effectiveness evaluation was conducted of an adult drug court (ADC) program as an alternative to jail for criminal offenders addicted to illicit drugs. This article describes the program, the cost-effectiveness analysis, and the results. The results of this study reveal that, for the 23-month period of the evaluation, the ADC was as cost-effective as were conventional sanctions in delaying the time to the first offense and more cost-effective in reducing the frequency of offending for those outcome measures selected. Although the evaluation was conducted using the traditional steps of a cost-effectiveness analysis, because of the complexity of the program and data limitations it was not always possible to adhere to textbook procedures. As such, each step involved in undertaking the cost-effectiveness analysis is discussed, highlighting the key issues faced in the evaluation.

Published
2004
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39. Committed Human CD23-Negative Light-Zone Germinal Center B Cells Delineate Transcriptional Program Supporting Plasma Cell Differentiation

Author

Santamaria, Kathleen, primary, Desmots, Fabienne, additional, Leonard, Simon, additional, Caron, Gersende, additional, Haas, Marion, additional, Delaloy, Céline, additional, Chatonnet, Fabrice, additional, Rossille, Delphine, additional, Pignarre, Amandine, additional, Monvoisin, Céline, additional, Seffals, Marine, additional, Lamaison, Claire, additional, Cogné, Michel, additional, Tarte, Karin, additional, and Fest, Thierry, additional

Published
2021
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