1,351 results on '"Hayashi, Katsuhiro"'
Search Results
2. Combined adipose-derived mesenchymal stem cell and antibiotic therapy can effectively treat periprosthetic joint infection in rats
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Yamamuro, Yuki, Kabata, Tamon, Nojima, Takayuki, Hayashi, Katsuhiro, Tokoro, Masaharu, Kajino, Yoshitomo, Inoue, Daisuke, Ohmori, Takaaki, Yoshitani, Junya, Ueno, Takuro, Ueoka, Ken, Taninaka, Atsushi, Kataoka, Tomoyuki, Saiki, Yoshitomo, Yanagi, Yu, and Tsuchiya, Hiroyuki
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- 2023
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3. Combining dynamics of serum inflammatory and nutritional indicators as novel biomarkers in immune checkpoint inhibitor treatment of non-small-cell lung cancer with bone metastases
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Asano, Yohei, Hayashi, Katsuhiro, Takeuchi, Akihiko, Kato, Satoshi, Miwa, Shinji, Taniguchi, Yuta, Okuda, Miho, Matsumoto, Isao, Yano, Seiji, and Demura, Satoru
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- 2024
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4. Combination therapy with immune checkpoint inhibitors and denosumab improves clinical outcomes in non-small cell lung cancer with bone metastases
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Asano, Yohei, Yamamoto, Norio, Demura, Satoru, Hayashi, Katsuhiro, Takeuchi, Akihiko, Kato, Satoshi, Miwa, Shinji, Igarashi, Kentaro, Higuchi, Takashi, Taniguchi, Yuta, Okuda, Miho, Matsumoto, Isao, Yano, Seiji, and Tsuchiya, Hiroyuki
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- 2024
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5. Massive star formation in the Carina nebula complex and Gum 31 -- II. a cloud-cloud collision in Gum 31
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Fujita, Shinji, Sano, Hidetoshi, Enokiya, Rei, Hayashi, Katsuhiro, Kohno, Mikito, Tsuge, Kisetsu, Tachihara, Kengo, Nishimura, Atsushi, Ohama, Akio, Yamane, Yumiko, Ohno, Takahiro, Yamada, Rin I., and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
We present the results of analyses of the 12CO (J=1-0), 13CO (J=1-0), and 12CO (J=2-1) emission data toward Gum 31. Three molecular clouds separated in velocity were detected at -25, -20, and -10 km/s . The velocity structure of the molecular clouds in Gum 31 cannot be interpreted as expanding motion. Two of them, the -25 km/s cloud and the -20 km/s cloud, are likely associated with Gum 31, because their 12CO (J=2-1)/12CO (J=1-0) intensity ratios are high. We found that these two clouds show the observational signatures of cloud-cloud collisions (CCCs): a complementary spatial distribution and a V-shaped structure (bridge features) in the position-velocity diagram. In addition, their morphology and velocity structures are very similar to the numerical simulations conducted by the previous studies. We propose a scenario that the -25 km/s cloud and the -20 km/s cloud were collided and triggered the formation of the massive star system HD 92206 in Gum 31. This scenario can explain the offset of the stars from the center and the morphology of Gum 31 simultaneously. The timescale of the collision was estimated to be ~1 Myr by using the ratio between the path length of the collision and the assumed velocity separation. This is consistent with that of the CCCs in Carina Nebula Complex in our previous study., Comment: Accepted for publication in PASJ
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- 2021
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6. Detailed Design of the Science Operations for the XRISM mission
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Terada, Yukikatsu, Holland, Matt, Loewenstein, Michael, Tashiro, Makoto, Takahashi, Hiromitsu, Nobukawa, Masayoshi, Mizuno, Tsunefumi, Tamura, Takayuki, Uno, Shin'ichiro, Watanabe, Shin, Baluta, Chris, Burns, Laura, Ebisawa, Ken, Eguchi, Satoshi, Fukazawa, Yasushi, Hayashi, Katsuhiro, Iizuka, Ryo, Katsuda, Satoru, Kitaguchi, Takao, Kubota, Aya, Miller, Eric, Mukai, Koji, Nakashima, Shinya, Nakazawa, Kazuhiro, Odaka, Hirokazu, Ohno, Masanori, Ota, Naomi, Sato, Rie, Sawada, Makoto, Sugawara, Yasuharu, Shidatsu, Megumi, Tamba, Tsubasa, Tanimoto, Atsushi, Terashima, Yuichi, Tsuboi, Yohko, Uchida, Yuusuke, Uchiyama, Hideki, Yamauchi, Shigeo, and Yaqoob, Tahir
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
XRISM is an X-ray astronomical mission by the JAXA, NASA, ESA and other international participants, that is planned for launch in 2022 (Japanese fiscal year), to quickly restore high-resolution X-ray spectroscopy of astrophysical objects. To enhance the scientific outputs of the mission, the Science Operations Team (SOT) is structured independently from the instrument teams and the Mission Operations Team. The responsibilities of the SOT are divided into four categories: 1) guest observer program and data distributions, 2) distribution of analysis software and the calibration database, 3) guest observer support activities, and 4) performance verification and optimization activities. As the first step, lessons on the science operations learned from past Japanese X-ray missions are reviewed, and 15 kinds of lessons are identified. Among them, a) the importance of early preparation of the operations from the ground stage, b) construction of an independent team for science operations separate from the instrument development, and c) operations with well-defined duties by appointed members are recognized as key lessons. Then, the team structure and the task division between the mission and science operations are defined; the tasks are shared among Japan, US, and Europe and are performed by three centers, the SOC, SDC, and ESAC, respectively. The SOC is designed to perform tasks close to the spacecraft operations, such as spacecraft planning, quick-look health checks, pre-pipeline processing, etc., and the SDC covers tasks regarding data calibration processing, maintenance of analysis tools, etc. The data-archive and user-support activities are covered both by the SOC and SDC. Finally, the science-operations tasks and tools are defined and prepared before launch., Comment: 42 pages, 7 figures, 8 table, Accepted for Publication in JATIS (SPIE)
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- 2021
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7. Comparison of clinical outcome between surgical treatment and particle beam therapy for pelvic bone sarcomas: A retrospective multicenter study in Japan
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Takemori, Toshiyuki, Hara, Hitomi, Kawamoto, Teruya, Fukase, Naomasa, Sawada, Ryoko, Fujiwara, Shuichi, Fujita, Ikuo, Fujimoto, Takuya, Morishita, Masayuki, Yahiro, Shunsuke, Miyamoto, Tomohiro, Saito, Masanori, Sugaya, Jun, Hayashi, Katsuhiro, Kawashima, Hiroyuki, Torigoe, Tomoaki, Nakamura, Tomoki, Kondo, Hiroya, Wakamatsu, Toru, Watanuki, Munenori, Kito, Munehisa, Tsukushi, Satoshi, Nagano, Akihito, Outani, Hidetatsu, Toki, Shunichi, Nishimura, Shunji, Kobayashi, Hiroshi, Watanabe, Itsuo, Demizu, Yusuke, Sasaki, Ryohei, Fukumoto, Takumi, Matsumoto, Tomoyuki, Kuroda, Ryosuke, and Akisue, Toshihiro
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- 2024
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8. Development of the new multi-beam receiver and telescope control system for NASCO
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Nishimura, Atsushi, Ohama, Akio, Kimura, Kimihiro, Tsutsumi, Daichi, Matsue, Yudai, Yamada, Rin, Sakamoto, Mariko, Matsunaga, Kenta, Hasegawa, Yutaka, Minami, Taisei, Matsumoto, Takeru, Shiotani, Kazuki, Okuda, So, Fujishiro, Kakeru, Sakasai, Keisuke, Suzuki, Masahiro, Saeki, Shun, Satani, Kouki, Urushihara, Kousuke, Kato, Chiharu, Kondo, Takashi, Okawa, Kazuki, Kurita, Daiki, Inaba, Tetsuta, Maruyama, Shohei, Koga, Masako, Noda, Kenya, Kohno, Mikito, Iwamura, Hiroaki, Hyoto, Yuki, Hori, Yuichi, Nishikawa, Kaoru, Nishioka, Takeru, Pang, Thoqin, Sano, Hidetoshi, Enokiya, Rei, Yoshiike, Satoshi, Fujita, Shinji, Hayashi, Katsuhiro, Torii, Kazufumi, Hayakawa, Takahiro, Taniguchi, Akio, Tsuge, Kisetsu, Yamane, Yumiko, Hattori, Yusuke, Ohno, Takahiro, Ueda, Shota, Masui, Sho, Yamasaki, Yasumasa, Kondo, Hiroshi, Suzuki, Kazuji, Kobayashi, Kazuhiro, Fujii, Yasunori, Fujii, Yumi, Minamidani, Tetsuhiro, Okuda, Takeshi, Yamamoto, Hiroaki, Tachihara, Kengo, Onishi, Toshikazu, Mizuno, Akira, Ogawa, Hideo, and Fukui, Yasuo
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We report the current status of the NASCO (NAnten2 Super CO survey as legacy) project which aims to provide all-sky CO data cube of southern hemisphere using the NANTEN2 4-m submillimeter telescope installed at the Atacama Desert through developing a new multi-beam receiver and a new telescope control system. The receiver consists of 5 beams. The four beams, located at the four corners of a square with the beam separation of 720$''$, are installed with a 100 GHz band SIS receiver having 2-polarization sideband-separation filter. The other beam, located at the optical axis, is installed with a 200 GHz band SIS receiver having 2-polarization sideband-separation filter. The cooled component is modularized for each beam, and cooled mirrors are used. The IF bandwidths are 8 and 4 GHz for 100 and 200 GHz bands, respectively. Using XFFTS spectrometers with a bandwidth of 2 GHz, the lines of $^{12}$CO, $^{13}$CO, and C$^{18}$O of $J$=1$-$0 or $J$=2$-$1 can be observed simultaneously for each beam. The control system is reconstructed on the ROS architecture, which is an open source framework for robot control, to enable a flexible observation mode and to handle a large amount of data. The framework is commonly used and maintained in a robotic field, and thereby reliability, flexibility, expandability, and efficiency in development are improved as compared with the system previously used. The receiver and control system are installed on the NANTEN2 telescope in December 2019, and its commissioning and science verification are on-going. We are planning to start science operation in early 2021., Comment: submitted to SPIE Astronomical Telescopes + Instrumentation (AS20), paper No. 11453-146
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- 2020
9. Origin of the in-orbit instrumental background of the Hard X-ray Imager onboard Hitomi
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Hagino, Kouichi, Odaka, Hirokazu, Sato, Goro, Sato, Tamotsu, Suzuki, Hiromasa, Mizuno, Tsunefumi, Kawaharada, Madoka, Ohno, Masanori, Nakazawa, Kazuhiro, Kobayashi, Shogo B., Murakami, Hiroaki, Miyake, Katsuma, Asai, Makoto, Koi, Tatsumi, Madejski, Greg, Saito, Shinya, Wright, Dennis H., Enoto, Teruaki, Fukazawa, Yasushi, Hayashi, Katsuhiro, Kataoka, Jun, Katsuta, Junichiro, Kokubun, Motohide, Laurent, Philippe, Lebrun, Francois, Limousin, Olivier, Maier, Daniel, Makishima, Kazuo, Mori, Kunishiro, Nakamori, Takeshi, Nakano, Toshio, Noda, Hirofumi, Ohta, Masayuki, Sato, Rie, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Tanaka, Takaaki, Terada, Yukikatsu, Uchiyama, Hideki, Uchiyama, Yasunobu, Watanabe, Shin, Yamaoka, Kazutaka, Yatsu, Yoichi, and Yuasa, Takayuki
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Understanding and reducing the in-orbit instrumental backgrounds are essential to achieving high sensitivity in hard X-ray astronomical observations. The observational data of the Hard X-ray Imager (HXI) on board the Hitomi satellite provides useful information on the background components, owing to its multi-layer configuration with different atomic numbers: the HXI consists of a stack of four layers of Si (Z = 14) detectors and one layer of CdTe (Z = 48, 52) detector surrounded by well-type BGO (Bi4Ge3O12) active shields. Based on the observational data, the backgrounds of top Si layer, the three underlying Si layers, and the CdTe layer are inferred to be dominated by different components, namely, low-energy electrons, albedo neutrons, and proton-induced radioactivation, respectively. Monte Carlo simulations of the in-orbit background of the HXI reproduce the observed background spectrum of each layer well, thereby verifying the above hypothesis quantitatively. In addition, we suggest the inclusion of an electron shield to reduce the background., Comment: 12 pages, 8 figures, accepted for publication in JATIS
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- 2020
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10. Safety evaluation of immune-cell therapy for malignant tumor in the Cancer Immune-cell Therapy Evaluation Group (CITEG)
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Takimoto, Rishu, Kamigaki, Takashi, Ito, Hisao, Saito, Masashi, Takizawa, Ken, Soejima, Kenzo, Yasuda, Hiroyuki, Ohgino, Keiko, Terai, Hideki, Tomita, Katsuro, Miura, Miyabi, Mizukoshi, Eishiro, Miyashita, Tomoharu, Nakamoto, Yasunari, Hayashi, Katsuhiro, Miwa, Shinji, Kitahara, Masaaki, Takeuchi, Akihiko, Kimura, Hiroaki, Mochizuki, Takafumi, Sugie, Hiroki, Seino, Ken-ichiro, Yamada, Tomonori, Takeuchi, Syuhei, Makita, Kaori, Naitoh, Keiko, Yasumoto, Kosei, Yoshida, Yoichiro, Inoue, Hiroyuki, Kotake, Katsuhiro, Ohshima, Kihachi, Noda, Shin-ei, Okamoto, Masahiko, Yoshimoto, Yuya, Okada, Sachiko, Ibe, Hiroshi, Oguma, Eri, and Goto, Shigenori
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- 2023
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11. Triggered high-mass star formation in the HII region W28A2: A cloud-cloud collision scenario
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Hayashi, Katsuhiro, Yoshiike, Satoshi, Enokiya, Rei, Fujita, Shinji, Yamada, Rin, Sano, Hidetoshi, Torii, Kazufumi, Kohno, Mikito, Nishimura, Atsushi, Ohama, Akio, Yamamoto, Hiroaki, Tachihara, Kengo, Wong, Graeme, Maxted, Nigel, Braiding, Catherine, Rowell, Gavin, Burton, Michael, and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
We report on a study of the high-mass star formation in the the HII region W28A2 by investigating the molecular clouds extended over ~5-10 pc from the exciting stars using the 12CO and 13CO (J=1-0) and 12CO (J=2-1) data taken by the NANTEN2 and Mopra observations. These molecular clouds consist of three velocity components with the CO intensity peaks at V_LSR ~ -4 km s$^{-1}$, 9 km s$^{-1}$ and 16 km s$^{-1}$. The highest CO intensity is detected at V_LSR ~ 9 km s$^{-1}$, where the high-mass stars with the spectral types of O6.5-B0.5 are embedded. We found bridging features connecting these clouds toward the directions of the exciting sources. Comparisons of the gas distributions with the radio continuum emission and 8 um infrared emission show spatial coincidence/anti-coincidence, suggesting physical associations between the gas and the exciting sources. The 12CO J=2-1 to 1-0 intensity ratio shows a high value (> 0.8) toward the exciting sources for the -4 km s$^{-1}$ and +9 km s$^{-1}$ clouds, possibly due to heating by the high-mass stars, whereas the intensity ratio at the CO intensity peak (V_LSR ~ 9 km s$^{-1}$) lowers down to ~0.6, suggesting self absorption by the dense gas in the near side of the +9 km s$^{-1}$ cloud. We found partly complementary gas distributions between the -4 km s$^{-1}$ and +9 km s$^{-1}$ clouds, and the -4 km s$^{-1}$ and +16 km s$^{-1}$ clouds. The exciting sources are located toward the overlapping region in the -4 km s$^{-1}$ and +9 km s$^{-1}$ clouds. Similar gas properties are found in the Galactic massive star clusters, RCW 38 and NGC 6334, where an early stage of cloud collision to trigger the star formation is suggested. Based on these results, we discuss a possibility of the formation of high-mass stars in the W28A2 region triggered by the cloud-cloud collision., Comment: 26 pages, 16 figures, Accepted for publication in PASJ
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- 2020
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12. Massive star formation in the Carina nebula complex and Gum 31 -- I. The Carina nebula complex
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Fujita, Shinji, Sano, Hidetoshi, Enokiya, Rei, Hayashi, Katsuhiro, Kohno, Mikito, Tsuge, Kisetsu, Tachihara, Kengo, Nishimura, Atsushi, Ohama, Akio, Yamane, Yumiko, Ohno, Takahiro, Yamada, Rin, and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
Herein, we present results from observations of the 12CO (J=1-0), 13CO (J=1-0), and 12CO (J=2-1) emission lines toward the Carina nebula complex (CNC) obtained with the Mopra and NANTEN2 telescopes. We focused on massive-star-forming regions associated with the CNC including the three star clusters Tr14, Tr15, and Tr16, and the isolated WR-star HD92740. We found that the molecular clouds in the CNC are separated into mainly four clouds at velocities -27, -20, -14, and -8 km/s. Their masses are 0.7x10^4Msun, 5.0x10^4 Msun, 1.6x10^4 Msun, and 0.7x10^4 Msun, respectively. Most are likely associated with the star clusters, because of their high 12CO (J=2-1)/12CO (J=1-0) intensity ratios and their correspondence to the Spitzer 8 micron distributions. In addition, these clouds show the observational signatures of cloud--cloud collisions. In particular, there is a V-shaped structure in the position--velocity diagram and a complementary spatial distribution between the -20 km/s cloud and the -14 km/s cloud. Based on these observational signatures, we propose a scenario wherein the formation of massive stars in the clusters was triggered by a collision between the two clouds. By using the path length of the collision and the assumed velocity separation, we estimate the timescale of the collision to be ~1 Myr. This is comparable to the ages of the clusters estimated in previous studies.
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- 2020
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13. Combination Methionine-methylation-axis Blockade: A Novel Approach to Target the Methionine Addiction of Cancer
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Higuchi, Takashi, Han, Qinghong, Sugisawa, Norihiko, Yamamoto, Jun, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, and Hoffman, Robert M
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Brain Disorders ,Cancer ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Animals ,Disease Models ,Animal ,Humans ,Methionine ,Methylation ,Mice ,Mice ,Nude ,Neoplasms ,methionine addiction ,methionine restriction ,methionine-methylation-axis blockade ,decitabine ,cycloleucine ,MAT2A ,soft-tissue sarcoma ,PDOX ,Immunology ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Background/aimCancers are selectively sensitive to methionine (MET) restriction (MR) due to their addiction to MET which is overused for elevated methylation reactions. MET addiction of cancer was discovered by us 45 years ago. MR of cancer results in depletion of S-adenosylmethionine (SAM) for transmethylation reactions, resulting in selective cancer-growth arrest in the late S/G2-phase of the cell cycle. The aim of the present study was to determine if blockade of the MET-methylation axis is a highly-effective strategy for cancer chemotherapy.Materials and methodsIn the present study, we demonstrated the efficacy of MET-methylation-axis blockade using MR by oral-recombinant methioninase (o-rMETase) combined with decitabine (DAC), an inhibitor of DNA methylation, and an inhibitor of SAM synthesis, cycloleucine (CL). We determined a proof-of-concept of the efficacy of the MET-methylation-axis blockade on a recalcitrant undifferentiated/unclassified soft-tissue sarcoma (USTS) patient-derived orthotopic xenograft (PDOX) mouse model.ResultsThe o-rMETase-CL-DAC combination regressed the USTS PDOX with extensive cancer necrosis.ConclusionThe new concept of combination MET-methylation-axis blockade is effective and can now be tested on many types of recalcitrant cancer.
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- 2021
14. High-mass star formation in Orion B triggered by cloud-cloud collision: Merging molecular clouds in NGC 2024
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Enokiya, Rei, Ohama, Akio, Yamada, Rin, Sano, Hidetoshi, Fujita, Shinji, Hayashi, Katsuhiro, Tsutsumi, Daichi, Torii, Kazufumi, Nishimura, Atsushi, konishi, Ryotaro, Yamamoto, Hiroaki, Tachihara, Kengo, Hasagawa, Yutaka, Kimura, Kimihiro, Ogawa, Hideo, and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
We performed new comprehensive $^{13}$CO($J$=2--1) observations toward NGC 2024, the most active star forming region in Orion B, with an angular resolution of $\sim$100'' obtained with NANTEN2. We found that the associated cloud consists of two independent velocity components. The components are physically connected to the H{\sc ii} region as evidenced by their close correlation with the dark lanes and the emission nebulosity. The two components show complementary distribution with a displacement of $\sim$0.6 pc. Such complementary distribution is typical to colliding clouds discovered in regions of high-mass star formation. We hypothesize that a cloud-cloud collision between the two components triggered the formation of the late O-type stars and early B stars localized within 0.3 pc of the cloud peak. The duration time of the collision is estimated to be 0.3 million years from a ratio of the displacement and the relative velocity $\sim$3 km s$^{-1}$ corrected for probable projection. The high column density of the colliding cloud $\sim$10$^{23}$ cm$^{-2}$ is similar to those in the other high-mass star clusters in RCW 38, Westerlund 2, NGC 3603, and M42, which are likely formed under trigger by cloud-cloud collision. The present results provide an additional piece of evidence favorable to high-mass star formation by a major cloud-cloud collision in Orion., Comment: 17 pages, 13 figures, accepted for PASJ. arXiv admin note: substantial text overlap with arXiv:1706.05652
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- 2019
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15. Fermi-LAT gamma-ray study of the interstellar medium and cosmic rays in the Chamaeleon Molecular-Cloud Complex: A look at the dark gas as optically thick HI
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Hayashi, Katsuhiro, Mizuno, Tsunefumi, Fukui, Yasuo, Okamoto, Ryuji, Yamamoto, Hiroaki, Hidaka, Naoya, Okumura, Akira, Tajima, Hiroyasu, and Sano, Hidetoshi
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report a Fermi-LAT $\gamma$-ray analysis for the Chamaeleon molecular-cloud complex using a total column density (NH) model based on the dust optical depth at 353 GHz ($\tau_{353}$) with the Planck thermal dust emission model. Gamma rays with energy from 250 MeV to 100 GeV are fitted with the NH model as a function of $\tau_{353}$, NH $\propto$ $\tau_{353}^{1/\alpha}$ ($\alpha$ $\geq$ 1.0), to explicitly take into account a possible nonlinear $\tau_{353}$/NH ratio. We found that a nonlinear relation, $\alpha$$\sim$1.4, gives the best fit to the $\gamma$-ray data. This nonlinear relation may indicate dust evolution effects across the different gas phases. Using the best-fit NH model, we derived the CO-to-H2 conversion factor (XCO) and gas mass, taking into account uncertainties of the NH model. The value of XCO is found to be (0.63-0.76) $\times$10$^{20}$ cm$^{-2}$ K$^{-1}$ km$^{-1}$ s, which is consistent with that of a recent $\gamma$-ray study of the Chamaeleon region. The total gas mass is estimated to be (6.0-7.3) $\times$ 10$^{4}$ Msun, of which the mass of additional gas not traced by standard HI or CO line surveys is 20-40%. The additional gas amounts to 30-60% of the gas mass estimated in the case of optically thin HI and has 5-7 times greater mass than the molecular gas traced by CO. Possible origins of the additional gas are discussed based on scenarios of optically thick HI and CO-dark H2. We also derived the $\gamma$-ray emissivity spectrum, which is consistent with the local HI emissivity derived from LAT data within the systematic uncertainty of $\sim$20%, Comment: 32 pages, 22 figures, accepted for ApJ
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- 2019
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16. Clinical features of patients with carcinoma soft tissue metastases as surgical indications: a retrospective cohort study
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Morinaga, Sei, primary, Yamamoto, Norio, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Miwa, Shinji, additional, Igarashi, Kentaro, additional, Taniguchi, Yuta, additional, Asano, Yohei, additional, Nojima, Takayuki, additional, and Tsuchiya, Hiroyuki, additional
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- 2024
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17. Development and validation of a nomogram to predict surgical site infection after soft-tissue sarcoma resection
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Miwa, Shinji, primary, Yamamoto, Norio, additional, Hayashi, Katsuhiro, additional, Takeuchi, Akihiko, additional, Igarashi, Kentaro, additional, Tada, Kaoru, additional, Taniguchi, Yuta, additional, Morinaga, Sei, additional, Asano, Yohei, additional, and Tsuchiya, Hiroyuki, additional
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- 2024
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18. Osimertinib regressed an EGFR-mutant lung-adenocarcinoma bone-metastasis mouse model and increased long-term survival
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Higuchi, Takashi, Sugisawa, Norihiko, Park, Jun Ho, Sun, Yu, Zhu, Guangwei, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, and Hoffman, Robert M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Lung Cancer ,Cancer ,Rare Diseases ,Lung ,Osimertinib ,Non-small-cell lung carcinoma ,Bone metastasis ,Orthotopic mouse model ,Biochemistry and Cell Biology ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
Bone is one of the most frequent metastatic sites in non-small cell lung cancer (NSCLC). Osimertinib, with and without bevacizumab (BV), has been investigated on advanced NSCLC patients. However, the efficacy of those drugs on bone metastasis of NSCLC has not been investigated. The human NSCLC cell line H1975, expressing red fluorescent protein (H1975-RFP), was orthotopically injected to the tibia of nude mice. The established mouse models were randomized into four treatment groups of nine mice: Control; BV alone; osimertinib alone; osimertinib and BV combination. The tumors were observed by non-invasive fluorescence imaging. Osimertinib, with or without BV, caused tumor regression, increased mouse survival, and bone remodeling in the bone metastasis models. These results suggest that osimertinib is a promising clinical option for NSCLS patients with bone metastasis.
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- 2020
19. The role of surgery in the treatment of metastatic bone tumor
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Hayashi, Katsuhiro and Tsuchiya, Hiroyuki
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- 2022
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20. Gas and Dust Properties in the Chamaeleon Molecular Cloud Complex based on the Optically Thick HI
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Hayashi, Katsuhiro, Okamoto, Ryuji, Yamamoto, Hiroaki, Hayakawa, Takahiro, Tachihara, Kengo, and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
Gas and dust properties in the Chamaeleon molecular cloud complex have been investigated with emission lines from atomic hydrogen (HI) and 12CO molecule, dust optical depth at 353 GHz ($\tau_{353}$), and $J$-band infrared extinction ($A_{J}$). We have found a scatter correlation between the HI integrated intensity ($W_{\rm HI}$) and $\tau_{353}$ in the Chamaeleon region. The scattering has been examined in terms of possible large optical depth in HI emission ($\tau_{\rm HI}$) using a total column density ($N_{\rm H}$) model based on $\tau_{353}$. A nonlinear relation of $\tau_{353}$ with the $\sim$1.2 power of $A_{J}$ has been found in opaque regions ($A_{J}$ $\gtrsim$ 0.3 mag), which may indicate dust evolution effect. If we apply this nonlinear relation to the $N_{\rm H}$ model (i.e., $N_{\rm H} \propto \tau_{353}^{1/1.2}$) allowing arbitrary $\tau_{\rm HI}$, the model curve reproduces well the $W_{\rm HI}$-$\tau_{353}$ scatter correlation, suggesting optically thick HI ($\tau_{\rm HI} \sim$1.3) extended around the molecular clouds. Based on the correlations between the CO integrated intensity and the $N_{\rm H}$ model, we have then derived the CO-to-H$_{2}$ conversion factor ($X_{\rm CO}$) on $\sim$1.5$^{\circ}$ scales (corresponding to $\sim$4 persec) and found spatial variations of $X_{\rm CO}$ $\sim$(0.5-3)$\times$10$^{20}$ cm$^{-2}$ K$^{-1}$ km$^{-1}$ s across the cloud complex, possibly depending on the radiation field inside or surrounding the molecular clouds. These gas properties found in the Chamaeleon region are discussed through a comparison with other local molecular cloud complexes., Comment: 30 pages, 21 figures, Accepted for ApJ
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- 2019
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21. Exquisite Tumor Targeting by Salmonella A1-R in Combination with Caffeine and Valproic Acid Regresses an Adult Pleomorphic Rhabdomyosarcoma Patient-Derived Orthotopic Xenograft Mouse Model.
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Igarashi, Kentaro, Kawaguchi, Kei, Zhao, Ming, Kiyuna, Tasuku, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D, Dry, Sarah M, Li, Yunfeng, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Higuchi, Takashi, Singh, Shree Ram, Tsuchiya, Hiroyuki, and Hoffman, Robert M
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Oncology & Carcinogenesis ,Biochemistry and Cell Biology ,Clinical Sciences ,Oncology and Carcinogenesis - Abstract
Adult pleomorphic rhabdomyosarcoma (RMS) is a rare and malignant mesenchymal tumor. Recently, we developed a patient-derived orthotopic xenograft (PDOX) model of adult pleomorphic RMS. In the present study, we evaluated the efficacy of tumor-targeting Salmonella typhimurium (S. typhimurium) A1-R combined with caffeine (CAF) and valproic acid (VPA) on the adult RMS PDOX. An adult pleomorphic RMS cell line was established from the PDOX model. Cell survival after exposure to CAF and VPA was assessed, and the IC50 value was calculated for each drug. The RMS PDOX models were randomized into five groups: untreated control; tumor treated with cyclophosphamide (CPA); tumor treated with CAF + VPA; tumor treated with S. typhimurium A1-R; and tumor treated with S. typhimurium A1-R + CAF + VPA. Tumor size and body weight was measured twice a week. VPA caused a concentration-dependent cytocidal effect. A synergistic effect of combination treatment with CAF was observed against the RMS cell line. For the in vivo study, all treatments significantly inhibited tumor growth compared with the untreated control. S. typhimurium A1-R combined with VPA and CAF was significantly more effective than CPA, VPA combined with CAF, or S. typhimurium A1-R alone and significantly regressed the tumor volume compared with day 0. These results suggest that S. typhimurium A1-R together with VPA and CAF could regresses an adult pleomorphic RMS in a PDOX model and therefore has important future clinical potential.
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- 2020
22. PPARγ Agonist Pioglitazone in Combination With Cisplatinum Arrests a Chemotherapy-resistant Osteosarcoma PDOX Model
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HIGUCHI, TAKASHI, YAMAMOTO, JUN, SUGISAWA, NORIHIKO, TASHIRO, YOSHIHIKO, NISHINO, HIROTO, YAMAMOTO, NORIO, HAYASHI, KATSUHIRO, KIMURA, HIROAKI, MIWA, SHINJI, IGARASHI, KENTARO, BOUVET, MICHAEL, SINGH, SHREE RAM, TSUCHIYA, HIROYUKI, and HOFFMAN, ROBERT M
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Orphan Drug ,Pediatric ,Rare Diseases ,Pediatric Cancer ,Clinical Research ,Cancer ,Adolescent ,Animals ,Antibiotics ,Antineoplastic ,Antineoplastic Agents ,Apoptosis ,Bone Neoplasms ,Cell Proliferation ,Cisplatin ,Doxorubicin ,Drug Resistance ,Neoplasm ,Drug Therapy ,Combination ,Humans ,Hypoglycemic Agents ,Male ,Mice ,Mice ,Nude ,Osteosarcoma ,PPAR gamma ,Pioglitazone ,Tumor Cells ,Cultured ,Xenograft Model Antitumor Assays ,pioglitazone ,cisplatinum ,drug resistance ,PDOX ,PPARγ ,Immunology ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
BACKGROUND/AIM:Cisplatinum (CDDP) is a first-line drug in osteosarcoma treatment and the acquisition of resistance to CDDP is associated with a poor prognosis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear hormone receptor that plays important roles in cell proliferation, differentiation, development, metabolism and cell death. Recently, PPARγ was reported to enhance the efficacy, overcome resistance, and decrease the toxicity of CDDP in various human cancers. In this study we tested whether pioglitazone (PIO), a PPARγ agonist, could overcome CDDP resistance in osteosarcoma. MATERIALS AND METHODS:In this study, we used a human osteosarcoma cell line and a patient-derived orthotopic xenograft (PDOX) models of osteosarcoma. We measured cell viability of 143B human osteosarcoma cells when treated with CDDP and PIO. We randomized PDOX models of osteosarcoma into four treatment groups: Group 1, Untreated control; Group 2, PIO alone; Group 3, CDDP alone; Group 4, a combination of CDDP and PIO. Each group comprised six mice. Mice were treated for 14 days and tumor size and body weight were measured. RESULTS:Cell viability of 143B human osteosarcoma cells was significantly reduced when PIO (50 μmol/l) was combined with CDDP compared to CDDP alone. PDOX osteosarcoma tumors treated with the CDDP-PIO combination showed the strongest tumor growth inhibition compared to other treatment groups. PDOX osteosarcoma tumors treated with the CDDP-PIO combination had the least cancer cells and the most necrosis in histological section. CONCLUSION:These results suggest that combining PIO along with CDDP could be an effective treatment strategy for osteosarcoma and has important clinical potential for patients.
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- 2020
23. A Novel Anionic-phosphate-platinum Complex Effectively Targets a Cisplatinum-resistant Osteosarcoma in a Patient-derived Orthotopic Xenograft Mouse Model
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IGARASHI, KENTARO, KAWAGUCHI, KEI, YAMAMOTO, NORIO, HAYASHI, KATSUHIRO, KIMURA, HIROAKI, MIWA, SHINJI, HIGUCHI, TAKASHI, TANIGUCHI, YUTA, YONEZAWA, HIROTAKA, ARAKI, YOSHIHIRO, MORINAGA, SEI, MISRA, SWETA, NELSON, SCOTT D, DRY, SARAH M, LI, YUNFENG, ODANI, AKIRA, SINGH, SHREE RAM, TSUCHIYA, HIROYUKI, and HOFFMAN, ROBERT M
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Cancer ,Pediatric Cancer ,Pediatric ,Rare Diseases ,Orphan Drug ,Development of treatments and therapeutic interventions ,5.1 Pharmaceuticals ,Adolescent ,Animals ,Anions ,Antineoplastic Agents ,Bone Neoplasms ,Cell Survival ,Cisplatin ,Drug Resistance ,Neoplasm ,Humans ,Mice ,Mice ,Nude ,Organoplatinum Compounds ,Osteosarcoma ,Phosphates ,Tumor Burden ,Tumor Cells ,Cultured ,Xenograft Model Antitumor Assays ,cisplatinum-resistant ,platinum complex ,efficacy ,3Pt ,PDOX ,Immunology ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
BACKGROUND/AIM:We have previously developed a novel bone-targeting platinum compound, 3Pt, and showed that it has strong inhibitory activity against osteosarcoma cells and orthotopic cell-line xenograft mouse models. In the present report, we compared the efficacy of 3Pt to cisplatinum (CDDP) in a CDDP-resistant relapsed osteosarcoma patient-derived orthotopic xenograft (PDOX) mouse model. PATIENTS AND METHODS:The tumor of a patient with osteosarcoma of the distal femur was treated with CDDP-based chemotherapy followed by surgery. The surgical specimen was used to establish a PDOX model. An osteosarcoma cell line was also established from the original patient tumor. Osteosarcoma cell viability was assessed with the WST-8 assay and the IC50 values were calculated. The PDOX models were randomized into three groups: untreated control, CDDP-treated group, and 3Pt-treated group. Tumor size and body weight were measured twice a week. RESULTS:3Pt had a strong concentration-dependent cytocidal effect in vitro. The IC50 value of 3Pt was significantly lower than that of CDDP. On day 14 of the treatment, 3Pt caused a significantly greater tumor growth inhibition compared to the untreated control and CDDP-treated mice. CONCLUSION:3Pt is a promising clinical candidate for the treatment of recalcitrant osteosarcoma.
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- 2020
24. Eribulin Regresses a Doxorubicin-resistant Dedifferentiated Liposarcoma in a Patient-derived Orthotopic Xenograft Mouse Model
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IGARASHI, KENTARO, KAWAGUCHI, KEI, KIYUNA, TASUKU, MIYAKE, KENTARO, HIGUCHI, TAKASHI, YAMAMOTO, NORIO, HAYASHI, KATSUHIRO, KIMURA, HIROAKI, MIWA, SHINJI, SINGH, SHREE RAM, TSUCHIYA, HIROYUKI, and HOFFMAN, ROBERT M
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Rare Diseases ,Good Health and Well Being ,Animals ,Antineoplastic Combined Chemotherapy Protocols ,Apoptosis ,Cell Dedifferentiation ,Cell Proliferation ,Deoxycytidine ,Docetaxel ,Doxorubicin ,Drug Resistance ,Neoplasm ,Furans ,Humans ,Indazoles ,Ketones ,Liposarcoma ,Male ,Mice ,Mice ,Nude ,Piperazines ,Pyridines ,Pyrimidines ,Sulfonamides ,Tumor Cells ,Cultured ,Xenograft Model Antitumor Assays ,Gemcitabine ,Patient-derived orthotopic xenograft ,PDOX ,eribulin ,regression ,doxorubicin resistance ,dedifferentiated liposarcoma ,Immunology ,Oncology & Carcinogenesis ,Oncology and carcinogenesis - Abstract
Background/aimDedifferentiated liposarcoma (DDLPS) is recalcitrant type of sarcoma. DDLPS has a low survival rate with high recurrence and metastasis. In the present study, we evaluated the efficacy of several drugs against doxorubicin-resistant DDLPS in a patient-derived orthotopic xenograft (PDOX) model for precision oncology. To establish the PDOX model, a tumor from a patient who had recurrent high-grade DDLPS from the retroperitoneum was previously grown orthotopically in the retroperitoneum of nude mice.Materials and methodsWe randomized DDLPS PDOX models into 8 treatment groups when tumor volume became approximately 100 mm3: control, no treatment; G2, doxorubicin (DOX); G3, pazopanib (PAZ); G4, gemcitabine (GEM) combined with docetaxel (DOC); G5, trabectedin (YON); G6, temozolomide (TEM); G7, palbociclib (PAL); G8, eribulin (ERB). Tumor length and width were measured both at the beginning and at the end of treatment.ResultsAt the end of treatment (day 14), all treatments significantly inhibited DDLPS PDOX tumor growth compared to the untreated control, except DOX. ERB was significantly more effective and regressed tumor volume compared to other treatments on day 14 after initiation of treatment. No significant differences were found in the relative body weight on day 14 compared to day 0 in any group.ConclusionThe clinical potential of ERB against DDLPS is herein presented in a PDOX model.
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- 2020
25. Detection of polarized gamma-ray emission from the Crab nebula with Hitomi Soft Gamma-ray Detector
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier, Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stephane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Lukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shin'ichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, and Uchida, Yuusuke
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the results from the Hitomi Soft Gamma-ray Detector (SGD) observation of the Crab nebula. The main part of SGD is a Compton camera, which in addition to being a spectrometer, is capable of measuring polarization of gamma-ray photons. The Crab nebula is one of the brightest X-ray / gamma-ray sources on the sky, and, the only source from which polarized X-ray photons have been detected. SGD observed the Crab nebula during the initial test observation phase of Hitomi. We performed the data analysis of the SGD observation, the SGD background estimation and the SGD Monte Carlo simulations, and, successfully detected polarized gamma-ray emission from the Crab nebula with only about 5 ks exposure time. The obtained polarization fraction of the phase-integrated Crab emission (sum of pulsar and nebula emissions) is (22.1 $\pm$ 10.6)% and, the polarization angle is 110.7$^o$ + 13.2 / $-$13.0$^o$ in the energy range of 60--160 keV (The errors correspond to the 1 sigma deviation). The confidence level of the polarization detection was 99.3%. The polarization angle measured by SGD is about one sigma deviation with the projected spin axis of the pulsar, 124.0$^o$ $\pm$0.1$^o$., Comment: 19 pages, 18 figures, 6 tables. Accepted for publication in PASJ
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- 2018
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26. Molecular gas in a Spitzer bubble N4: possible evidence for cloud-cloud collisions as a trigger of massive star formation
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Fujita, Shinji, Torii, Kazufumi, Tachihara, Kengo, Enokiya, Rei, Hayashi, Katsuhiro, Kuno, Nario, Kohno, Mikito, Tosaki, Tomoka, Yamagishi, Mitsuyoshi, Nishimura, Atsushi, Umemoto, Tomofumi, Minamidani, Tetsuhiro, Matsuo, Mitsuhiro, Tsuda, Yuya, Sano, Hidetoshi, Tsutsumi, Daichi, Ohama, Akio, Yoshiike, Satoshi, Okawa, Kazuki, Fukui, Yasuo, and Members, Other Fugin
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
Herein, we present the 12CO (J=1-0) and 13CO (J=1-0) emission line observations via the FOREST Unbiased Galactic plane Imaging survey with the Nobeyama 45-m telescope (FUGIN) toward a Spitzer bubble N4. We observed clouds of three discrete velocities: 16, 19, and 25 km/s. Their masses were 0.1x10^4 Msun, 0.3x10^4 Msun, and 1.4x10^4 Msun, respectively. The distribution of the 25-km/s cloud likely traces the ring-like structure observed at mid-infrared wavelength. We could not find clear expanding motion of the molecular gas in N4. On the contrary, we found a bridge feature and a complementary distribution, which are discussed as observational signatures of a cloud-cloud collision, between the 16- and 25-km/s clouds. We proposed a possible scenario wherein the formation of a massive star in N4 was triggered by a collision between the two clouds; however whereas the 19-km/s cloud is possibly not a part of the interaction with N4. The time scale of collision is estimated to be 0.2-0.3 Myr, which is comparable to the estimated dynamical age of the HII region of ~0.4 Myr. In N4W, a star-forming clump located west of N4, we observed molecular outflows from young stellar objects and the observational signature of a cloud-cloud collision. Thus, we also proposed a possible scenario in which massive- or intermediate-mass star formation was triggered via a cloud-cloud collision in N4W.
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- 2018
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27. The Combination of Olaratumab with Doxorubicin and Cisplatinum Regresses a Chemotherapy-Resistant Osteosarcoma in a Patient-Derived Orthotopic Xenograft Mouse Model
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Higuchi, Takashi, Sugisawa, Norihiko, Miyake, Kentaro, Oshiro, Hiromichi, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, and Hoffman, Robert M
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Rare Diseases ,Pediatric ,Orphan Drug ,Pediatric Cancer ,Cancer ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Biochemistry and Cell Biology ,Clinical Sciences ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
Chemotherapy-resistant osteosarcoma is a recalcitrant disease. It is a frequent cause of death to the patients who are usually adolescent or young adults. The goal of the present study was to determine the efficacy of the combination of olaratumab (OLA), doxorubicin (DOX), and cisplatinum (CDDP) on osteosarcoma, which is resistant to first-line therapy, in a patient-derived orthotopic xenograft (PDOX) model. The osteosarcoma PDOX model was randomized into six treatment groups of six mice: control; CDDP alone; DOX and CDDP; OLA + DOX; OLA + CDDP; and OLA + DOX and CDDP. Tumor size and body weight were measured during 14 days of treatment. Tumor growth was regressed only by the treatment with a combination of OLA + DOX and CDDP. Tumors treated with this three-drug combination had the most tumor necrosis and the lowest Ki-67 index. The present study demonstrates the power of the PDOX model to identify novel effective treatment strategy for chemotherapy-resistant osteosarcoma.
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- 2019
28. Extensive Synergy Between Recombinant Methioninase and Eribulin Against Fibrosarcoma Cells But Not Normal Fibroblasts
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MORINAGA, SEI, primary, HAN, QINGHONG, additional, KUBOTA, YUTARO, additional, MIZUTA, KOHEI, additional, KANG, BYUNG MO, additional, SATO, MOTOKAZU, additional, BOUVET, MICHAEL, additional, YAMAMOTO, NORIO, additional, HAYASHI, KATSUHIRO, additional, KIMURA, HIROAKI, additional, MIWA, SHINJI, additional, IGARASHI, KENTARO, additional, HIGUCHI, TAKASHI, additional, TSUCHIYA, HIROYUKI, additional, and HOFFMAN, ROBERT M., additional
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- 2024
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29. Primary total knee arthroplasty assisted by computed tomography-free navigation for secondary knee osteoarthritis following massive calcium phosphate cement packing for distal femoral giant-cell bone tumor treatment: a case report
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Takeuchi, Akihiko, Yamamoto, Norio, Ohmori, Takaaki, Hayashi, Katsuhiro, Miwa, Shinji, Igarashi, Kentaro, Higuchi, Takashi, Abe, Kensaku, Yonezawa, Hirotaka, Morinaga, Sei, Araki, Yoshihiro, Asano, Yohei, Saito, Shiro, and Tsuchiya, Hiroyuki
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- 2022
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30. Family cancer history and smoking habit associated with sarcoma in a Japanese population study
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Araki, Yoshihiro, Yamamoto, Norio, Tanzawa, Yoshikazu, Higashi, Takahiro, Kuchiba, Aya, Hayashi, Katsuhiro, Takeuchi, Akihiko, Miwa, Shinji, Igarashi, Kentaro, Endo, Makoto, Kobayashi, Eisuke, Tsuchiya, Hiroyuki, and Kawai, Akira
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- 2022
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31. Insufficiency fracture of the supra-acetabulum that required differentiation from a pathological fracture secondary to a malignant bone tumor: a case report
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Morinaga, Sei, Yamamoto, Norio, Hayashi, Katsuhiro, Takeuchi, Akihiko, Miwa, Shinji, Igarashi, Kentaro, Yonezawa, Hirotaka, Asano, Yohei, Saito, Shiro, and Tsuchiya, Hiroyuki
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- 2022
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32. A scoring system combining clinical, radiological, and histopathological examinations for differential diagnosis between lipoma and atypical lipomatous tumor/well-differentiated liposarcoma
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Asano, Yohei, Miwa, Shinji, Yamamoto, Norio, Hayashi, Katsuhiro, Takeuchi, Akihiko, Igarashi, Kentaro, Yonezawa, Hirotaka, Araki, Yoshihiro, Morinaga, Sei, Nojima, Takayuki, Ikeda, Hiroko, and Tsuchiya, Hiroyuki
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- 2022
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33. In-orbit performance and calibration of the Hard X-ray Imager onboard Hitomi (ASTRO-H)
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Hagino, Kouichi, Nakazawa, Kazuhiro, Sato, Goro, Kokubun, Motohide, Enoto, Teruaki, Fukazawa, Yasushi, Hayashi, Katsuhiro, Kataoka, Jun, Katsuta, Junichiro, Kobayashi, Shogo B., Laurent, Philippe, Lebrun, Francois, Limousin, Olivier, Maier, Daniel, Makishima, Kazuo, Mimura, Taketo, Miyake, Katsuma, Mizuno, Tsunefumi, Mori, Kunishiro, Murakami, Hiroaki, Nakamori, Takeshi, Nakano, Toshio, Noda, Hirofumi, Odaka, Hirokazu, Ohno, Masanori, Ohta, Masayuki, Saito, Shinya, Sato, Rie, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Tanaka, Takaaki, Terada, Yukikatsu, Uchiyama, Hideki, Uchiyama, Yasunobu, Watanabe, Shin, Yamaoka, Kazutaka, Yatsu, Yoichi, and Yuasa, Takayuki
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Hard X-ray Imager (HXI) onboard Hitomi (ASTRO-H) is an imaging spectrometer covering hard X-ray energies of 5-80 keV. Combined with the hard X-ray telescope, it enables imaging spectroscopy with an angular resolution of $1^\prime.7$ half-power diameter, in a field of view of $9^\prime\times9^\prime$. The main imager is composed of 4 layers of Si detectors and 1 layer of CdTe detector, stacked to cover wide energy band up to 80 keV, surrounded by an active shield made of BGO scintillator to reduce the background. The HXI started observations 12 days before the Hitomi loss, and successfully obtained data from G21.5$-$0.9, Crab and blank sky. Utilizing these data, we calibrate the detector response and study properties of in-orbit background. The observed Crab spectra agree well with a powerlaw model convolved with the detector response, within 5% accuracy. We find that albedo electrons in specified orbit strongly affect the background of Si top layer, and establish a screening method to reduce it. The background level over the full field of view after all the processing and screening is as low as the pre-flight requirement of $1$-$3\times10^{-4}$ counts s$^{-1}$ cm$^{-2}$ keV$^{-1}$., Comment: 46 pages, 18 figures, published in Journal of Astronomical Telescopes, Instruments, and Systems
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- 2018
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34. Modeling of proton-induced radioactivation background in hard X-ray telescopes: Geant4-based simulation and its demonstration by Hitomi's measurement in a low Earth orbit
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Odaka, Hirokazu, Asai, Makoto, Hagino, Kouichi, Koi, Tatsumi, Madejski, Greg, Mizuno, Tsunefumi, Ohno, Masanori, Saito, Shinya, Sato, Tamotsu, Wright, Dennis H., Enoto, Teruaki, Fukazawa, Yasushi, Hayashi, Katsuhiro, Kataoka, Jun, Katsuta, Junichiro, Kawaharada, Madoka, Kobayashi, Shogo B., Kokubun, Motohide, Laurent, Philippe, Lebrun, Francois, Limousin, Olivier, Maier, Daniel, Makishima, Kazuo, Mimura, Taketo, Miyake, Katsuma, Mori, Kunishiro, Murakami, Hiroaki, Nakamori, Takeshi, Nakano, Toshio, Nakazawa, Kazuhiro, Noda, Hirofumi, Ohta, Masayuki, Ozaki, Masanobu, Sato, Goro, Sato, Rie, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Tanaka, Takaaki, Tanaka, Yasuyuki, Terada, Yukikatsu, Uchiyama, Hideki, Uchiyama, Yasunobu, Watanabe, Shin, Yamaoka, Kazutaka, Yasuda, Tetsuya, Yatsu, Yoichi, Yuasa, Takayuki, and Zoglauer, Andreas
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Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
Hard X-ray astronomical observatories in orbit suffer from a significant amount of background due to radioactivation induced by cosmic-ray protons and/or geomagnetically trapped protons. Within the framework of a full Monte Carlo simulation, we present modeling of in-orbit instrumental background dominated by radioactivation. To reduce the computation time required by straightforward simulations of delayed emissions from activated isotopes, we insert a semi-analytical calculation that converts production probabilities of radioactive isotopes by interaction of the primary protons into decay rates at measurement time of all secondary isotopes. Therefore, our simulation method is separated into three steps: (1) simulation of isotope production, (2) semi-analytical conversion to decay rates, and (3) simulation of decays of the isotopes at measurement time. This method is verified by a simple setup that has a CdTe semiconductor detector, and shows a 100-fold improvement in efficiency over the straightforward simulation. The simulation framework was tested against data measured with a CdTe sensor in the Hard X-ray Imager onboard the Hitomi X-ray Astronomy Satellite, which was put into a low Earth orbit with an altitude of 570 km and an inclination of 31 degrees, and thus experienced a large amount of irradiation from geomagnetically trapped protons during its passages through the South Atlantic Anomaly. The simulation is able to treat full histories of the proton irradiation and multiple measurement windows. The simulation results agree very well with the measured data, showing that the measured background is well described by the combination of proton-induced radioactivation of the CdTe detector itself and thick Bi4Ge3O12 scintillator shields, leakage of cosmic X-ray background and albedo gamma-ray radiation, and emissions from naturally contaminated isotopes in the detector system., Comment: 18 pages, 13 figures
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- 2018
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35. Hitomi X-ray Observation of the Pulsar Wind Nebula G21.5$-$0.9
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier, Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sato, Toshiki, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Łukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shin'ichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, Nakaniwa, Nozomu, Murakami, Hiroaki, and Guest, Benson
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present results from the Hitomi X-ray observation of a young composite-type supernova remnant (SNR) G21.5$-$0.9, whose emission is dominated by the pulsar wind nebula (PWN) contribution. The X-ray spectra in the 0.8-80 keV range obtained with the Soft X-ray Spectrometer (SXS), Soft X-ray Imager (SXI) and Hard X-ray Imager (HXI) show a significant break in the continuum as previously found with the NuSTAR observation. After taking into account all known emissions from the SNR other than the PWN itself, we find that the Hitomi spectra can be fitted with a broken power law with photon indices of $\Gamma_1=1.74\pm0.02$ and $\Gamma_2=2.14\pm0.01$ below and above the break at $7.1\pm0.3$ keV, which is significantly lower than the NuSTAR result ($\sim9.0$ keV). The spectral break cannot be reproduced by time-dependent particle injection one-zone spectral energy distribution models, which strongly indicates that a more complex emission model is needed, as suggested by recent theoretical models. We also search for narrow emission or absorption lines with the SXS, and perform a timing analysis of PSR J1833$-$1034 with the HXI and SGD. No significant pulsation is found from the pulsar. However, unexpectedly, narrow absorption line features are detected in the SXS data at 4.2345 keV and 9.296 keV with a significance of 3.65 $\sigma$. While the origin of these features is not understood, their mere detection opens up a new field of research and was only possible with the high resolution, sensitivity and ability to measure extended sources provided by an X-ray microcalorimeter., Comment: 16 pages, 8 figures, 4 tables. Accepted for publication in PASJ
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- 2018
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36. Temperature Structure in the Perseus Cluster Core Observed with Hitomi
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furukawa, Maki, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Kato, Yuichi, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier, Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Łukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shiníchiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shiníchiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, and Zoghbi, Abderahmen
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The present paper investigates the temperature structure of the X-ray emitting plasma in the core of the Perseus cluster using the 1.8--20.0 keV data obtained with the Soft X-ray Spectrometer (SXS) onboard the Hitomi Observatory. A series of four observations were carried out, with a total effective exposure time of 338 ks and covering a central region $\sim7'$ in diameter. The SXS was operated with an energy resolution of $\sim$5 eV (full width at half maximum) at 5.9 keV. Not only fine structures of K-shell lines in He-like ions but also transitions from higher principal quantum numbers are clearly resolved from Si through Fe. This enables us to perform temperature diagnostics using the line ratios of Si, S, Ar, Ca, and Fe, and to provide the first direct measurement of the excitation temperature and ionization temperature in the Perseus cluster. The observed spectrum is roughly reproduced by a single temperature thermal plasma model in collisional ionization equilibrium, but detailed line ratio diagnostics reveal slight deviations from this approximation. In particular, the data exhibit an apparent trend of increasing ionization temperature with increasing atomic mass, as well as small differences between the ionization and excitation temperatures for Fe, the only element for which both temperatures can be measured. The best-fit two-temperature models suggest a combination of 3 and 5 keV gas, which is consistent with the idea that the observed small deviations from a single temperature approximation are due to the effects of projection of the known radial temperature gradient in the cluster core along the line of sight. Comparison with the Chandra/ACIS and the XMM-Newton/RGS results on the other hand suggests that additional lower-temperature components are present in the ICM but not detectable by Hitomi SXS given its 1.8--20 keV energy band., Comment: 29 pages, 19 figures, 9 tables. Accepted for publication in PASJ
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- 2017
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37. Atomic data and spectral modeling constraints from high-resolution X-ray observations of the Perseus cluster with Hitomi
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hell, Natalie, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier, Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Łukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shin'ichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, and Raassen, A. J. J.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The Hitomi SXS spectrum of the Perseus cluster, with $\sim$5 eV resolution in the 2-9 keV band, offers an unprecedented benchmark of the atomic modeling and database for hot collisional plasmas. It reveals both successes and challenges of the current atomic codes. The latest versions of AtomDB/APEC (3.0.8), SPEX (3.03.00), and CHIANTI (8.0) all provide reasonable fits to the broad-band spectrum, and are in close agreement on best-fit temperature, emission measure, and abundances of a few elements such as Ni. For the Fe abundance, the APEC and SPEX measurements differ by 16%, which is 17 times higher than the statistical uncertainty. This is mostly attributed to the differences in adopted collisional excitation and dielectronic recombination rates of the strongest emission lines. We further investigate and compare the sensitivity of the derived physical parameters to the astrophysical source modeling and instrumental effects. The Hitomi results show that an accurate atomic code is as important as the astrophysical modeling and instrumental calibration aspects. Substantial updates of atomic databases and targeted laboratory measurements are needed to get the current codes ready for the data from the next Hitomi-level mission., Comment: 46 pages, 25 figures, 11 tables. Accepted for publication in PASJ
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- 2017
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38. Hitomi Observations of the LMC SNR N132D: Highly Redshifted X-ray Emission from Iron Ejecta
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier, Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sato, Toshiki, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Łukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shin'ichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, and Zoghbi, Abderahmen
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present Hitomi observations of N132D, a young, X-ray bright, O-rich core-collapse supernova remnant in the Large Magellanic Cloud (LMC). Despite a very short observation of only 3.7 ks, the Soft X-ray Spectrometer (SXS) easily detects the line complexes of highly ionized S K and Fe K with 16-17 counts in each. The Fe feature is measured for the first time at high spectral resolution. Based on the plausible assumption that the Fe K emission is dominated by He-like ions, we find that the material responsible for this Fe emission is highly redshifted at ~800 km/s compared to the local LMC interstellar medium (ISM), with a 90% credible interval of 50-1500 km/s if a weakly informative prior is placed on possible line broadening. This indicates (1) that the Fe emission arises from the supernova ejecta, and (2) that these ejecta are highly asymmetric, since no blue-shifted component is found. The S K velocity is consistent with the local LMC ISM, and is likely from swept-up ISM material. These results are consistent with spatial mapping that shows the He-like Fe concentrated in the interior of the remnant and the S tracing the outer shell. The results also show that even with a very small number of counts, direct velocity measurements from Doppler-shifted lines detected in extended objects like supernova remnants are now possible. Thanks to the very low SXS background of ~1 event per spectral resolution element per 100 ks, such results are obtainable during short pointed or slew observations with similar instruments. This highlights the power of high-spectral-resolution imaging observations, and demonstrates the new window that has been opened with Hitomi and will be greatly widened with future missions such as the X-ray Astronomy Recovery Mission (XARM) and Athena., Comment: 18 pages, 15 figures, 1 table. Accepted for publication by PASJ
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- 2017
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39. Glimpse of the highly obscured HMXB IGR J16318-4848 with Hitomi
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier O., Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sawada, Makoto, Schartel, Norbert, Serlemitsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Łukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shin'ichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, and Nakaniwa, Nozomi
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report a Hitomi observation of IGR J16318-4848, a high-mass X-ray binary system with an extremely strong absorption of N_H~10^{24} cm^{-2}. Previous X-ray studies revealed that its spectrum is dominated by strong fluorescence lines of Fe as well as continuum emission. For physical and geometrical insight into the nature of the reprocessing material, we utilize the high spectroscopic resolving power of the X-ray microcalorimeter (the soft X-ray spectrometer; SXS) and the wide-band sensitivity by the soft and hard X-ray imager (SXI and HXI) aboard Hitomi. Even though photon counts are limited due to unintended off-axis pointing, the SXS spectrum resolves Fe K{\alpha_1} and K{\alpha_2} lines and puts strong constraints on the line centroid and width. The line width corresponds to the velocity of 160^{+300}_{-70} km s^{-1}. This represents the most accurate, and smallest, width measurement of this line made so far from any X-ray binary, much less than the Doppler broadening and shift expected from speeds which are characteristic of similar systems. Combined with the K-shell edge energy measured by the SXI and HXI spectra, the ionization state of Fe is estimated to be in the range of Fe I--IV. Considering the estimated ionization parameter and the distance between the X-ray source and the absorber, the density and thickness of the materials are estimated. The extraordinarily strong absorption and the absence of a Compton shoulder component is confirmed. These characteristics suggest reprocessing materials which are distributed in a narrow solid angle or scattering primarily with warm free electrons or neutral hydrogen., Comment: 17 pages, 9 figures, 2 tables, accepted for publication in PASJ
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- 2017
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40. Hitomi Observation of Radio Galaxy NGC 1275: The First X-ray Microcalorimeter Spectroscopy of Fe-K{\alpha} Line Emission from an Active Galactic Nucleus
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier O., Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sawada, Makoto, Schartel, Norbert, Serlemitsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Łukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shin'ichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, and Kawamuro, Taiki
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The origin of the narrow Fe-K{\alpha} fluorescence line at 6.4 keV from active galactic nuclei has long been under debate; some of the possible sites are the outer accretion disk, the broad line region, a molecular torus, or interstellar/intracluster media. In February-March 2016, we performed the first X-ray microcalorimeter spectroscopy with the Soft X-ray Spectrometer (SXS) onboard the Hitomi satellite of the Fanaroff-Riley type I radio galaxy NGC 1275 at the center of the Perseus cluster of galaxies. With the high energy resolution of ~5 eV at 6 keV achieved by Hitomi/SXS, we detected the Fe-K{\alpha} line with ~5.4 {\sigma} significance. The velocity width is constrained to be 500-1600 km s$^{-1}$ (FWHM for Gaussian models) at 90% confidence. The SXS also constrains the continuum level from the NGC 1275 nucleus up to ~20 keV, giving an equivalent width ~20 eV of the 6.4 keV line. Because the velocity width is narrower than that of broad H{\alpha} line of ~2750 km s$^{-1}$, we can exclude a large contribution to the line flux from the accretion disk and the broad line region. Furthermore, we performed pixel map analyses on the Hitomi/SXS data and image analyses on the Chandra archival data, and revealed that the Fe-K{\alpha} line comes from a region within ~1.6 kpc from the NGC 1275 core, where an active galactic nucleus emission dominates, rather than that from intracluster media. Therefore, we suggest that the source of the Fe-K{\alpha} line from NGC 1275 is likely a low-covering fraction molecular torus or a rotating molecular disk which probably extends from a pc to hundreds pc scale in the active galactic nucleus system., Comment: 20 pages, 8 figures, 6 tables, accepted for publication in PASJ
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- 2017
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41. Massive star formation in W51A triggered by cloud-cloud collisions
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Fujita, Shinji, Torii, Kazufumi, Kuno, Nario, Nishimura, Atsushi, Umemoto, Tomofumi, Minamidani, Tetsuhiro, Kohno, Mikito, Yamagishi, Mitsuyoshi, Tosaki, Tomoka, Matsuo, Mitsuhiro, Tsuda, Yuya, Tachihara, Kengo, Ohama, Akio, Sano, Hidetoshi, Hayashi, Katsuhiro, Enokiya, Rei, Yoshiike, Satoshi, Tsutsumi, Daichi, Okawa, Kazuki, Fukui, Yasuo, and members, other FUGIN
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
W51A is one of the most active star-forming region in our Galaxy, which contains giant molecular clouds with a total mass of 10^6 Msun. The molecular clouds have multiple velocity components over ~20 km/s, and interactions between these components have been discussed as the mechanism which triggered the massive star formation in W51A. In this paper, we report an observational study of the molecular clouds in W51A using the new 12CO, 13CO, and C18O (J=1-0) data covering a 1.4x1.0 degree region of W51A obtained with the Nobeyama 45-m telescope at 20" resolution. Our CO data resolved the four discrete velocity clouds at 50, 56, 60, and 68 km/s with sizes and masses of ~30 pc and 1.0-1.9x10^5 Msun. Toward the central part of the HII region complex G49.5-0.4, we identified four C18O clumps having sizes of ~1 pc and column densities of higher than 10^23 cm^-3, which are each embedded within the four velocity clouds. These four clumps are distributed close to each others within a small distance of 5 pc, showing a complementary distribution on the sky. In the position-velocity diagram, these clumps are connected with each others by bridge features with intermediate intensities. The high intensity ratios of 13CO (J=3-2/J=1-0) also indicates that these four clouds are associated with the HII regions. We also found these features in other HII regions in W51A. The timescales of the collisions are estimated to be several 0.1 Myrs as a crossing time of the clouds, which are consistent with the ages of the HII regions measured from the size of the HII regions in the 21 cm continuum emissions. We discuss the cloud-cloud collision scenario and massive star formation in W51A by comparing with the recent observational and theoretical studies of cloud-cloud collision., Comment: 53 pages, 23 figures
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- 2017
42. Detailed CO ($J$ = 1--0, 2--1 and 3--2) observations toward an H{\sc ii} region RCW~32 in the Vela Molecular Ridge
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Enokiya, Rei, Sano, Hidetoshi, Hayashi, Katsuhiro, Tachihara, Kengo, Torii, Kazufumi, Yamamoto, Hiroaki, Hattori, Yusuke, Hasegawa, Yutaka, Ohama, Akio, Kimura, Kimihiro, Ogawa, Hideo, and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies ,Astrophysics - Solar and Stellar Astrophysics - Abstract
We made CO ($J$ = 1--0, 2--1, and 3--2) observations toward an H{\sc ii} region RCW~32 in the Vela Molecular Ridge. The CO gas distribution associated with the H{\sc ii} region was revealed for the first time at a high resolution of 22 arcsec. The results revealed three distinct velocity components which show correspondence with the optical dark lanes and/or H$\alpha$ distribution. Two of the components show complementary spatial distribution which suggests collisional interaction between them at a relative velocity of $\sim$4 km~s$^{-1}$. Based on these results, we present a hypothesis that cloud-cloud collision determined the cloud distribution and triggered formation of the exciting star ionizing RCW~32. The collision time scale is estimated from the cloud size and the velocity separation to be $\sim$2 Myrs and the collision terminated $\sim$1 Myr ago, which is consistent with an age of the exciting star and the associated cluster. By combing the previous works on the H{\sc ii} regions in the Vela Molecular Ridge, we argue that the majority, at least four, of the H{\sc ii} regions in the Ridge were formed by triggering of cloud-cloud collision., Comment: 22 pages, 8 figures
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- 2017
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43. Atmospheric gas dynamics in the Perseus cluster observed with Hitomi
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Canning, Rebecca E. A., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashi, Tasuku, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Shota, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier, Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Łukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shin'ichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Keigo, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shin'ichiro, Urry, C. Megan, Ursino, Eugenio, Wang, Qian H. S., Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, and Zoghbi, Abderahmen
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Extending the earlier measurements reported in Hitomi collaboration (2016, Nature, 535, 117), we examine the atmospheric gas motions within the central 100~kpc of the Perseus cluster using observations obtained with the Hitomi satellite. After correcting for the point spread function of the telescope and using optically thin emission lines, we find that the line-of-sight velocity dispersion of the hot gas is remarkably low and mostly uniform. The velocity dispersion reaches maxima of approximately 200~km~s$^{-1}$ toward the central active galactic nucleus (AGN) and toward the AGN inflated north-western `ghost' bubble. Elsewhere within the observed region, the velocity dispersion appears constant around 100~km~s$^{-1}$. We also detect a velocity gradient with a 100~km~s$^{-1}$ amplitude across the cluster core, consistent with large-scale sloshing of the core gas. If the observed gas motions are isotropic, the kinetic pressure support is less than 10\% of the thermal pressure support in the cluster core. The well-resolved optically thin emission lines have Gaussian shapes, indicating that the turbulent driving scale is likely below 100~kpc, which is consistent with the size of the AGN jet inflated bubbles. We also report the first measurement of the ion temperature in the intracluster medium, which we find to be consistent with the electron temperature. In addition, we present a new measurement of the redshift to the brightest cluster galaxy NGC~1275., Comment: 52 pages, 16 figures, 8 tables, accepted for publication in PASJ
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- 2017
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44. Measurements of resonant scattering in the Perseus cluster core with Hitomi SXS
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Greg V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier O., Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stephane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sato, Toshiki, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Lukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shinichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shinichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, Furukawa, Maki, and Ogorzalek, Anna
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Thanks to its high spectral resolution (~5 eV at 6 keV), the Soft X-ray Spectrometer (SXS) on board Hitomi enables us to measure the detailed structure of spatially resolved emission lines from highly ionized ions in galaxy clusters for the first time. In this series of papers, using the SXS we have measured the velocities of gas motions, metallicities and the multi-temperature structure of the gas in the core of the Perseus cluster. Here, we show that when inferring physical properties from line emissivities in systems like Perseus, the resonant scattering (RS) effect should be taken into account. In the Hitomi waveband, RS mostly affects the FeXXV He$\alpha$ line ($w$) - the strongest line in the spectrum. The flux measured by Hitomi in this line is suppressed by a factor ~1.3 in the inner ~30 kpc, compared to predictions for an optically thin plasma; the suppression decreases with the distance from the center. The $w$ line also appears slightly broader than other lines from the same ion. The observed distortions of the $w$ line flux, shape and distance dependence are all consistent with the expected effect of the resonant scattering in the Perseus core. By measuring the ratio of fluxes in optically thick ($w$) and thin (FeXXV forbidden, He$\beta$, Ly$\alpha$) lines, and comparing these ratios with predictions from Monte Carlo radiative transfer simulations, the velocities of gas motions have been obtained. The results are consistent with the direct measurements of gas velocities from line broadening described elsewhere in this series, although the systematic and statistical uncertainties remain significant. Further improvements in the predictions of line emissivities in plasma models, and deeper observations with future X-ray missions will enable RS measurements to provide powerful constraints on the amplitude and anisotropy of clusters gas motions., Comment: 30 pages, 17 figure, 6 tables, accepted for publication in PASJ
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- 2017
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45. Molecular and Atomic Clouds toward the Wolf-Rayet Nebula NGC 2359: Possible Evidence for Isolated High-Mass Star Formation Triggered by a Cloud-Cloud Collision
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Sano, Hidetoshi, Hayashi, Katsuhiro, Enokiya, Rei, Torii, Kazufumi, Saeki, Shun, Okawa, Kazuki, Tsuge, Kisetsu, Tsutsumi, Daichi, Kohno, Mikito, Hattori, Yusuke, Fujita, Shinji, Yoshiike, Satoshi, Okamoto, Ryuji, Nishimura, Atsushi, Ohama, Akio, Hayakawa, Takahiro, Yamamoto, Hiroaki, Tachihara, Kengo, Cappa, Cristina Elisabet, and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
NGC 2359 is an HII region located in the outer Galaxy that contains the isolated Wolf-Rayet (WR) star HD 56925. We present millimeter/submillimeter observations of $^{12}$CO($J$ = 1-0, 3-2) line emission toward the entire nebula. We identified that there are three molecular clouds at VLSR $\sim$37, $\sim$54, and $\sim$67 km s$^{-1}$, and three HI clouds: two of them are at VLSR $\sim$54 km s$^{-1}$ and the other is at $\sim$63 km s$^{-1}$. These clouds except for the CO cloud at 67 km s$^{-1}$ are limb-brightened in the radio continuum, suggesting part of each cloud has been ionized. We newly found an expanding gas motion of CO/HI, whose center and expansion velocities are $\sim$51 and $\sim$4.5 km s$^{-1}$, respectively. This is consistent with large line widths of the CO and HI clouds at 54 km s$^{-1}$. The kinematic temperature of CO clouds at 37 and 54 km s$^{-1}$ are derived to be 17 and 61 K, respectively, whereas that of the CO cloud at 67 km s$^{-1}$ is only 6 K, indicating that the former two clouds have been heated by strong UV radiation. We concluded that the 37 and 54 km s$^{-1}$ CO clouds and three HI clouds are associated with NGC 2359, even if these clouds have different velocities. Although the velocity difference including the expanding motion are typical signatures of the stellar feedback from the exciting star, our analysis revealed that the observed large momentum for the 37 km s$^{-1}$ CO cloud cannot be explained only by the total wind momentum of the WR star and its progenitor. We therefore propose an alternative scenario that the isolated high-mass progenitor of HD 56925 was formed by a collision between the CO clouds at 37 and 54 km s$^{-1}$. If we apply the collision scenario, NGC 2359 corresponds to the final phase of the cloud-cloud collision., Comment: 38 pages, 13 figures, 1 table, submitted to Publications of the Astronomical Society of Japan (PASJ)
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- 2017
46. Osimertinib Regresses an EGFR-Mutant Cisplatinum- Resistant Lung Adenocarcinoma Growing in the Brain in Nude Mice
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Higuchi, Takashi, Oshiro, Hiromichi, Zhang, Zhiying, Miyake, Kentaro, Sugisawa, Norihiko, Katsuya, Yuki, Yamamoto, Norio, Hayashi, Katsuhiro, Kimura, Hiroaki, Miwa, Shinji, Igarashi, Kentaro, Zhao, Ming, Bouvet, Michael, Singh, Shree Ram, Tsuchiya, Hiroyuki, and Hoffman, Robert M
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Lung ,Lung Cancer ,Cancer ,Biochemistry and Cell Biology ,Oncology & Carcinogenesis ,Biochemistry and cell biology ,Oncology and carcinogenesis - Abstract
The goal of the present study was to determine the efficacy of osimertinib (AZD9291), a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor for the treatment of aggressive EGFR-mutant non-small cell lung cancer (NSCLC), compared to cisplatinum (CDDP) + pemetrexed (PEM). The NSCLC cell line PC-9 expressing green fluorescence protein (PC-9-GFP) was implanted in the brain of nude mice and was treated with CDDP + PEM or AZD9291. Tumors were observed by non-invasive fluorescence imaging. AZD9291 treatment caused tumor regression in contrast to CDDP + PEM which had only a slight inhibitory effect. These results suggest that AZD9291 is a promising clinical option for NSCLC patients with brain metastasis.
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- 2019
47. Hitomi X-ray studies of Giant Radio Pulses from the Crab pulsar
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Gregory V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Iwai, Masachika, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier O., Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Oshimizu, Kenya, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stéphane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Ł ukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shiníchiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shiníchiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, Terasawa, Toshio, Sekido, Mamoru, Takefuji, Kazuhiro, Kawai, Eiji, Misawa, Hiroaki, Tsuchiya, Fuminori, Yamazaki, Ryo, Kobayashi, Eiji, Kisaka, Shota, and Aoki, Takahiro
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
To search for giant X-ray pulses correlated with the giant radio pulses (GRPs) from the Crab pulsar, we performed a simultaneous observation of the Crab pulsar with the X-ray satellite Hitomi in the 2 -- 300 keV band and the Kashima NICT radio observatory in the 1.4 -- 1.7 GHz band with a net exposure of about 2 ks on 25 March 2016, just before the loss of the Hitomi mission.The timing performance of the Hitomi instruments was confirmed to meet the timing requirement and about 1,000 and 100 GRPs were simultaneously observed at the main and inter-pulse phases, respectively, and we found no apparent correlation between the giant radio pulses and the X-ray emission in either the main or inter-pulse phases.All variations are within the 2 sigma fluctuations of the X-ray fluxes at the pulse peaks, and the 3 sigma upper limits of variations of main- or inter- pulse GRPs are 22\% or 80\% of the peak flux in a 0.20 phase width, respectively, in the 2 -- 300 keV band.The values become 25\% or 110\% for main or inter-pulse GRPs, respectively, when the phase width is restricted into the 0.03 phase.Among the upper limits from the Hitomi satellite, those in the 4.5-10 keV and the 70-300 keV are obtained for the first time, and those in other bands are consistent with previous reports.Numerically, the upper limits of main- and inter-pulse GRPs in the 0.20 phase width are about (2.4 and 9.3) $\times 10^{-11}$ erg cm$^{-2}$, respectively. No significant variability in pulse profiles implies that the GRPs originated from a local place within the magnetosphere and the number of photon-emitting particles temporally increases.However, the results do not statistically rule out variations correlated with the GRPs, because the possible X-ray enhancement may appear due to a $>0.02$\% brightening of the pulse-peak flux under such conditions., Comment: 18 pages, 7 figure, 6 tables, accepted for publication in PASJ
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- 2017
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48. Search for Thermal X-ray Features from the Crab nebula with Hitomi Soft X-ray Spectrometer
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Hitomi Collaboration, Aharonian, Felix, Akamatsu, Hiroki, Akimoto, Fumie, Allen, Steven W., Angelini, Lorella, Audard, Marc, Awaki, Hisamitsu, Axelsson, Magnus, Bamba, Aya, Bautz, Marshall W., Blandford, Roger, Brenneman, Laura W., Brown, Greg V., Bulbul, Esra, Cackett, Edward M., Chernyakova, Maria, Chiao, Meng P., Coppi, Paolo S., Costantini, Elisa, de Plaa, Jelle, de Vries, Cor P., Herder, Jan-Willem den, Done, Chris, Dotani, Tadayasu, Ebisawa, Ken, Eckart, Megan E., Enoto, Teruaki, Ezoe, Yuichiro, Fabian, Andrew C., Ferrigno, Carlo, Foster, Adam R., Fujimoto, Ryuichi, Fukazawa, Yasushi, Furuzawa, Akihiro, Galeazzi, Massimiliano, Gallo, Luigi C., Gandhi, Poshak, Giustini, Margherita, Goldwurm, Andrea, Gu, Liyi, Guainazzi, Matteo, Haba, Yoshito, Hagino, Kouichi, Hamaguchi, Kenji, Harrus, Ilana M., Hatsukade, Isamu, Hayashi, Katsuhiro, Hayashi, Takayuki, Hayashida, Kiyoshi, Hiraga, Junko S., Hornschemeier, Ann, Hoshino, Akio, Hughes, John P., Ichinohe, Yuto, Iizuka, Ryo, Inoue, Hajime, Inoue, Yoshiyuki, Ishida, Manabu, Ishikawa, Kumi, Ishisaki, Yoshitaka, Kaastra, Jelle, Kallman, Tim, Kamae, Tsuneyoshi, Kataoka, Jun, Katsuda, Satoru, Kawai, Nobuyuki, Kelley, Richard L., Kilbourne, Caroline A., Kitaguchi, Takao, Kitamoto, Shunji, Kitayama, Tetsu, Kohmura, Takayoshi, Kokubun, Motohide, Koyama, Katsuji, Koyama, Shu, Kretschmar, Peter, Krimm, Hans A., Kubota, Aya, Kunieda, Hideyo, Laurent, Philippe, Lee, Shiu-Hang, Leutenegger, Maurice A., Limousin, Olivier O., Loewenstein, Michael, Long, Knox S., Lumb, David, Madejski, Greg, Maeda, Yoshitomo, Maier, Daniel, Makishima, Kazuo, Markevitch, Maxim, Matsumoto, Hironori, Matsushita, Kyoko, McCammon, Dan, McNamara, Brian R., Mehdipour, Missagh, Miller, Eric D., Miller, Jon M., Mineshige, Shin, Mitsuda, Kazuhisa, Mitsuishi, Ikuyuki, Miyazawa, Takuya, Mizuno, Tsunefumi, Mori, Hideyuki, Mori, Koji, Mukai, Koji, Murakami, Hiroshi, Mushotzky, Richard F., Nakagawa, Takao, Nakajima, Hiroshi, Nakamori, Takeshi, Nakashima, Shinya, Nakazawa, Kazuhiro, Nobukawa, Kumiko K., Nobukawa, Masayoshi, Noda, Hirofumi, Odaka, Hirokazu, Ohashi, Takaya, Ohno, Masanori, Okajima, Takashi, Ota, Naomi, Ozaki, Masanobu, Paerels, Frits, Paltani, Stephane, Petre, Robert, Pinto, Ciro, Porter, Frederick S., Pottschmidt, Katja, Reynolds, Christopher S., Safi-Harb, Samar, Saito, Shinya, Sakai, Kazuhiro, Sasaki, Toru, Sato, Goro, Sato, Kosuke, Sato, Rie, Sato, Toshiki, Sawada, Makoto, Schartel, Norbert, Serlemtsos, Peter J., Seta, Hiromi, Shidatsu, Megumi, Simionescu, Aurora, Smith, Randall K., Soong, Yang, Stawarz, Lukasz, Sugawara, Yasuharu, Sugita, Satoshi, Szymkowiak, Andrew, Tajima, Hiroyasu, Takahashi, Hiromitsu, Takahashi, Tadayuki, Takeda, Shinichiro, Takei, Yoh, Tamagawa, Toru, Tamura, Takayuki, Tanaka, Takaaki, Tanaka, Yasuo, Tanaka, Yasuyuki T., Tashiro, Makoto S., Tawara, Yuzuru, Terada, Yukikatsu, Terashima, Yuichi, Tombesi, Francesco, Tomida, Hiroshi, Tsuboi, Yohko, Tsujimoto, Masahiro, Tsunemi, Hiroshi, Tsuru, Takeshi Go, Uchida, Hiroyuki, Uchiyama, Hideki, Uchiyama, Yasunobu, Ueda, Shutaro, Ueda, Yoshihiro, Uno, Shinichiro, Urry, C. Megan, Ursino, Eugenio, Watanabe, Shin, Werner, Norbert, Wilkins, Dan R., Williams, Brian J., Yamada, Shinya, Yamaguchi, Hiroya, Yamaoka, Kazutaka, Yamasaki, Noriko Y., Yamauchi, Makoto, Yamauchi, Shigeo, Yaqoob, Tahir, Yatsu, Yoichi, Yonetoku, Daisuke, Zhuravleva, Irina, Zoghbi, Abderahmen, Tominaga, Nozomu, and Moriya, Takashi J.
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Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Astrophysics of Galaxies - Abstract
The Crab nebula originated from a core-collapse supernova (SN) explosion observed in 1054 A.D. When viewed as a supernova remnant (SNR), it has an anomalously low observed ejecta mass and kinetic energy for an Fe-core collapse SN. Intensive searches were made for a massive shell that solves this discrepancy, but none has been detected. An alternative idea is that the SN1054 is an electron-capture (EC) explosion with a lower explosion energy by an order of magnitude than Fe-core collapse SNe. In the X-rays, imaging searches were performed for the plasma emission from the shell in the Crab outskirts to set a stringent upper limit to the X-ray emitting mass. However, the extreme brightness of the source hampers access to its vicinity. We thus employed spectroscopic technique using the X-ray micro-calorimeter onboard the Hitomi satellite. By exploiting its superb energy resolution, we set an upper limit for emission or absorption features from yet undetected thermal plasma in the 2-12 keV range. We also re-evaluated the existing Chandra and XMM-Newton data. By assembling these results, a new upper limit was obtained for the X-ray plasma mass of <~ 1Mo for a wide range of assumed shell radius, size, and plasma temperature both in and out of the collisional equilibrium. To compare with the observation, we further performed hydrodynamic simulations of the Crab SNR for two SN models (Fe-core versus EC) under two SN environments (uniform ISM versus progenitor wind). We found that the observed mass limit can be compatible with both SN models if the SN environment has a low density of <~ 0.03 cm-3 (Fe core) or <~ 0.1 cm-3 (EC) for the uniform density, or a progenitor wind density somewhat less than that provided by a mass loss rate of 10-5 Mo yr-1 at 20 km s-1 for the wind environment., Comment: PASJ in press. Figures are now properly included
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- 2017
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49. High-mass star formation possibly triggered by cloud-cloud collision in the HII region RCW 34
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Hayashi, Katsuhiro, Sano, Hidetoshi, Enokiya, Rei, Torii, Kazufumi, Hattori, Yusuke, Kohno, Mikito, Fujita, Shinji, Nishimura, Atsushi, Ohama, Akio, Yamamoto, Hiroaki, Tachihara, Kengo, Hasegawa, Yutaka, Kimura, Kimihiro, Ogawa, Hideo, and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
We report a possibility that the high-mass star located in the HII region RCW 34 was formed by a triggering induced by a collision of molecular clouds. Molecular gas distributions of the $^{12}$CO and $^{13}$CO $J=$2-1, and $^{12}$CO $J=$3-2 lines toward RCW 34 were measured by using the NANTEN2 and ASTE telescopes. We found two clouds with the velocity ranges of 0-10 km s$^{-1}$ and 10-14 km s$^{-1}$. Whereas the former cloud as massive as ~2.7 x 10$^{4}$ Msun has a morphology similar to the ring-like structure observed in the infrared wavelengths, the latter cloud with the mass of ~10$^{3}$ Msun, which has not been recognized by previous observations, distributes just likely to cover the bubble enclosed by the other cloud. The high-mass star with the spectral types of O8.5V is located near the boundary of the two clouds. The line intensity ratio of $^{12}$CO $J=$3-2 / $J=$2-1 yields high values (~1.5) in the neighborhood of the high-mass star, suggesting that these clouds are associated with the massive star. We also confirmed that the obtained position-velocity diagram shows a similar distribution with that derived by a numerical simulation of the supersonic collision of two clouds. Using the relative velocity between the two clouds (~5 km s$^{-1}$), the collisional time scale is estimated to be $\sim$0.2 Myr with the assumption of the distance of 2.5 kpc. These results suggest that the high-mass star in RCW 34 was formed rapidly within a time scale of ~0.2 Myr via a triggering of cloud-cloud collision., Comment: 18 pages, 10 figures, 2 tables, accepted for Publications of the Astronomical Society of Japan (PASJ)
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- 2017
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50. RCW 36 in the Vela Molecular Ridge: Evidence for a high-mass star cluster formation triggered by Cloud-Cloud Collision
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Sano, Hidetoshi, Enokiya, Rei, Hayashi, Katsuhiro, Yamagishi, Mitsuyoshi, Saeki, Shun, Okawa, Kazuki, Tsuge, Kisetsu, Tsutsumi, Daichi, Kohno, Mikito, Hattori, Yusuke, Yoshiike, Satoshi, Fujita, Shinji, Nishimura, Atsushi, Ohama, Akio, Tachihara, Kengo, Torii, Kazufumi, Hasegawa, Yutaka, Kimura, Kimihiro, Ogawa, Hideo, Wong, Graeme F., Braiding, Catherine, Rowell, Gavin, Burton, Michael G., and Fukui, Yasuo
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Astrophysics - Astrophysics of Galaxies - Abstract
A collision between two molecular clouds is one possible candidate for high-mass star formation. The HII region RCW 36, located in the Vela molecular ridge, contains a young star cluster with two O-type stars. We present new CO observations of RCW 36 with NANTEN2, Mopra, and ASTE using $^{12}$CO($J$ = 1-0, 2-1, 3-2) and $^{13}$CO($J$ = 2-1) line emissions. We have discovered two molecular clouds lying at the velocities $V_\mathrm{LSR} \sim$5.5 and 9 km s$^{-1}$. Both clouds are likely to be physically associated with the star cluster, as verified by the good spatial correspondence among the two clouds, infrared filaments, and the star cluster. We also found a high intensity ratio of $\sim$0.6-1.2 for CO $J$ = 3-2 / 1-0 toward both clouds, indicating that the gas temperature has been increased due to heating by the O-type stars. We propose that the O-type stars in RCW 36 were formed by a collision between the two clouds, with a relative velocity separation of 5 km s$^{-1}$. The complementary spatial distributions and the velocity separation of the two clouds are in good agreement with observational signatures expected for O-type star formation triggered by a cloud-cloud collision. We also found a displacement between the complementary spatial distributions of the two clouds, which we estimate to be 0.3 pc assuming the collision angle to be 45$^{\circ}$ relative to the line-of-sight. We estimate the collision timescale to be $\sim$10$^5$ yr. It is probable that the cluster age by Ellerbroek et al. (2013b) is dominated by the low-mass members which were not formed under the triggering by cloud-cloud collision, and that the O-type stars in the center of the cluster are explained by the collisional triggering independently from the low-mass star formation., Comment: 13 pages, 9 figures, and 2 tables, accepted for publication in PASJ
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- 2017
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- View/download PDF
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