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534 results on '"Hicks, Belynda"'

1. Genomic profiles and clinical presentation of chordoma.

Author

Koka, Hela, Zhou, Weiyin, McMaster, Mary, Bai, Jiwei, Luo, Wen, Klein, Alyssa, Zhang, Tongwu, Hua, Xing, Li, Xin, Wang, Difei, Xiong, Yujia, Jones, Kristine, Vogt, Aurelie, Hicks, Belynda, Parry, Dilys, Goldstein, Allen, and Yang, Xiaohong

Subjects
Chordoma, Chordoma sites, Clinical outcome, Genomic landscape, Treatment, Humans, Chordoma, Male, Female, Middle Aged, Aged, Adult, Adolescent, Young Adult, Child, Child, Preschool, DNA-Binding Proteins, Mutation, Class I Phosphatidylinositol 3-Kinases, T-Box Domain Proteins, Transcription Factors, Nuclear Proteins, Skull Base Neoplasms, Spinal Neoplasms, Canada, Polymorphism, Single Nucleotide, Fetal Proteins, Histone-Lysine N-Methyltransferase
Abstract

Chordoma is a rare bone cancer with variable clinical outcomes. Here, we recruited 184 sporadic chordoma patients from the US and Canada and collected their clinical and treatment data. The average age at diagnosis was 45.5 years (Range 5-78) and the chordoma site distribution was 49.2% clivus, 26.2% spinal, and 24.0% sacral. Most patients (97.5%) received surgery as the primary treatment, among whom 85.3% also received additional treatment. Except for the most prevalent cancers like prostate, lung, breast, and skin cancer, there was no discernible enrichment for any specific cancer type among patients or their family members. Among a subset of patients (N = 70) with tumor materials, we conducted omics analyses and obtained targeted panel sequencing and SNP array genotyping data for 51 and 49 patients, respectively. The most recurrent somatic driver mutations included PIK3CA (12%), followed by chromatin remodeling genes PBRM1 and SETD2. Amplification of the 6q27 region, containing the chordoma susceptibility gene TBXT, was detected in eight patients (16.3%). Clival patients appeared to be less likely to carry driver gene mutations, chromosome arm level deletion events (e.g., 5p, 5p, and 9p), or 6q27 amplification compared to sacral patients. After adjusting for age, sex, tumor site, and additional treatment, patients with somatic deletions of 14q (OR = 13.73, 95% CI 1.96-96.02, P = 0.008) and 18p (OR = 13.68, 95% CI 1.77-105.89, P = 0.012) were more likely to have persistent chordoma. The study highlights genomic heterogeneity in chordoma, potentially linked to location and clinical progression.

Published
2024

2. Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.

Author

Kim, Jung, Vaksman, Zalman, Egolf, Laura, Kaufman, Rebecca, Evans, J, Conkrite, Karina, Danesh, Arnavaz, Lopez, Gonzalo, Randall, Michael, Dent, Maiah, Farra, Lance, Menghani, Neil, Dymek, Malwina, Desai, Heena, Hausler, Ryan, Hicks, Belynda, Auvil, Jaime, Gerhard, Daniela, Hakonarson, Hakon, Maxwell, Kara, Cole, Kristina, Pugh, Trevor, Bosse, Kristopher, Khan, Javed, Wei, Jun, Maris, John, Stewart, Douglas, and Diskin, Sharon

Subjects
Child, Humans, Genetic Predisposition to Disease, Prospective Studies, BRCA1 Protein, Germ-Line Mutation, Neuroblastoma, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases
Abstract

BACKGROUND: Neuroblastoma is an embryonal cancer of the developing sympathetic nervous system. The genetic contribution of rare pathogenic or likely pathogenic germline variants in patients without a family history remains unclear. METHODS: Germline DNA sequencing was performed on 786 neuroblastoma patients. The frequency of rare cancer predisposition gene pathogenic or likely pathogenic variants in patients was compared with 2 cancer-free control cohorts. Matched tumor DNA sequencing was evaluated for second hits, and germline DNA array data from 5585 neuroblastoma patients and 23 505 cancer-free control children were analyzed to identify rare germline copy number variants. Patients with germline pathogenic or likely pathogenic variants were compared with those without to test for association with clinical characteristics, tumor features, and survival. RESULTS: We observed 116 pathogenic or likely pathogenic variants involving 13.9% (109 of 786) of neuroblastoma patients, representing a statistically significant excess burden compared with cancer-free participants (odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.27 to 2.00). BARD1 harbored the most statistically significant enrichment of pathogenic or likely pathogenic variants (OR = 32.30, 95% CI = 6.44 to 310.35). Rare germline copy number variants disrupting BARD1 were identified in patients but absent in cancer-free participants (OR = 29.47, 95% CI = 1.52 to 570.70). Patients harboring a germline pathogenic or likely pathogenic variant had a worse overall survival compared with those without (P = 8.6 x 10-3). CONCLUSIONS: BARD1 is an important neuroblastoma predisposition gene harboring both common and rare germline pathogenic or likely pathogenic variations. The presence of any germline pathogenic or likely pathogenic variant in a cancer predisposition gene was independently predictive of worse overall survival. As centers move toward paired tumor-normal sequencing at diagnosis, efforts should be made to centralize data and provide an infrastructure to support cooperative longitudinal prospective studies of germline pathogenic variation.

Published
2024

3. Frequency of pathogenic germline variants in pediatric medulloblastoma survivors.

Author

Rees, Donald, Gianferante, D, Kim, Jung, Stavrou, Theodora, Reaman, Gregory, Sapkota, Yadav, Gramatges, M, Morton, Lindsay, Hudson, Melissa, Armstrong, Gregory, Freedman, Neal, Huang, Wen-Yi, Diver, W, Lori, Adriana, Luo, Wen, Hicks, Belynda, Liu, Jia, Hutchinson, Amy, Goldstein, Alisa, and Mirabello, Lisa

Subjects
germline, medulloblastoma, pathogenic, pediatric, survivor
Abstract

BACKGROUND: Medulloblastoma is the most common malignant brain tumor in children. Most cases are sporadic, but well characterized germline alterations in APC, ELP1, GPR161, PTCH1, SUFU, and TP53 predispose to medulloblastoma. However, knowledge about pathogenic/likely pathogenic (P/LP) variants that predispose to medulloblastoma vary based on genes evaluated, patient demographics, and pathogenicity definitions. METHODS: Germline exome sequencing was conducted on 160 childhood survivors of medulloblastoma. Analyses focused on rare variants in 239 known cancer susceptibility genes (CSGs). P/LP variants were identified using ClinVar and InterVar. Variants of unknown significance in known medulloblastoma predisposing genes (APC, ELP1, GPR161, PTCH1, SUFU, TP53) were further classified for loss of function variants. We compared the frequency of P/LP variants in cases to that in 1,259 cancer-free adult controls. RESULTS: Twenty cases (12.5%) had a P/LP variant in an autosomal dominant CSG versus 5% in controls (p=1.0 x10-3), and 10 (6.3%) of these were P/LP variants in a known medulloblastoma gene, significantly greater than 0.2% observed in controls (p=1.4x10-8). The CSGs with the most P/LP variants in cases, and significantly higher than controls, were ELP1 (p=3.0x10-4) and SUFU (p=1.4x10-3). CONCLUSION: Approximately one in eight pediatric medulloblastoma survivors had an autosomal dominant P/LP CSG variant. We confirm several known associated genes and identify novel genes that may be important in medulloblastoma.

Published
2024

4. Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Author

Purdue, Mark P., Dutta, Diptavo, Machiela, Mitchell J., Gorman, Bryan R., Winter, Timothy, Okuhara, Dayne, Cleland, Sara, Ferreiro-Iglesias, Aida, Scheet, Paul, Liu, Aoxing, Wu, Chao, Antwi, Samuel O., Larkin, James, Zequi, Stênio C., Sun, Maxine, Hikino, Keiko, Hajiran, Ali, Lawson, Keith A., Cárcano, Flavio, Blanchet, Odile, Shuch, Brian, Nepple, Kenneth G., Margue, Gaëlle, Sundi, Debasish, Diver, W. Ryan, Folgueira, Maria A. A. K., van Bokhoven, Adrie, Neffa, Florencia, Brown, Kevin M., Hofmann, Jonathan N., Rhee, Jongeun, Yeager, Meredith, Cole, Nathan R., Hicks, Belynda D., Manning, Michelle R., Hutchinson, Amy A., Rothman, Nathaniel, Huang, Wen-Yi, Linehan, W. Marston, Lori, Adriana, Ferragu, Matthieu, Zidane-Marinnes, Merzouka, Serrano, Sérgio V., Magnabosco, Wesley J., Vilas, Ana, Decia, Ricardo, Carusso, Florencia, Graham, Laura S., Anderson, Kyra, Bilen, Mehmet A., Arciero, Cletus, Pellegrin, Isabelle, Ricard, Solène, Scelo, Ghislaine, Banks, Rosamonde E., Vasudev, Naveen S., Soomro, Naeem, Stewart, Grant D., Adeyoju, Adebanji, Bromage, Stephen, Hrouda, David, Gibbons, Norma, Patel, Poulam, Sullivan, Mark, Protheroe, Andrew, Nugent, Francesca I., Fournier, Michelle J., Zhang, Xiaoyu, Martin, Lisa J., Komisarenko, Maria, Eisen, Timothy, Cunningham, Sonia A., Connolly, Denise C., Uzzo, Robert G., Zaridze, David, Mukeria, Anush, Holcatova, Ivana, Hornakova, Anna, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Gaborieau, Valérie, Abedi-Ardekani, Behnoush, McKay, James, Johansson, Mattias, Phouthavongsy, Larry, Hayman, Lindsay, Li, Jason, Lungu, Ilinca, Bezerra, Stephania M., Souza, Aline G., Sares, Claudia T. G., Reis, Rodolfo B., Gallucci, Fabio P., Cordeiro, Mauricio D., Pomerantz, Mark, Lee, Gwo-Shu M., Freedman, Matthew L., Jeong, Anhyo, Greenberg, Samantha E., Sanchez, Alejandro, Thompson, R. Houston, Sharma, Vidit, Thiel, David D., Ball, Colleen T., Abreu, Diego, Lam, Elaine T., Nahas, William C., Master, Viraj A., Patel, Alpa V., Bernhard, Jean-Christophe, Freedman, Neal D., Bigot, Pierre, Reis, Rui M., Colli, Leandro M., Finelli, Antonio, Manley, Brandon J., Terao, Chikashi, Choueiri, Toni K., Carraro, Dirce M., Houlston, Richard, Eckel-Passow, Jeanette E., Abbosh, Philip H., Ganna, Andrea, Brennan, Paul, Gu, Jian, and Chanock, Stephen J.

Published
2024
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5. Associations of Circulating Estrogens and Estrogen Metabolites with Fecal and Oral Microbiome in Postmenopausal Women in the Ghana Breast Health Study.

Author

Wu, Zeni, Pfeiffer, Ruth, Byrd, Doratha, Wan, Yunhu, Ansong, Daniel, Clegg-Lamptey, Joe-Nat, Wiafe-Addai, Beatrice, Edusei, Lawrence, Adjei, Ernest, Titiloye, Nicholas, Dedey, Florence, Aitpillah, Francis, Oppong, Joseph, Vanderpuye, Verna, Osei-Bonsu, Ernest, Dagnall, Casey, Jones, Kristine, Hutchinson, Amy, Hicks, Belynda, Ahearn, Thomas, Biritwum, Richard, Yarney, Joel, Wiafe, Seth, Awuah, Baffour, Nyarko, Kofi, Garcia-Closas, Montserrat, Sinha, Rashmi, Figueroa, Jonine, Brinton, Louise, Trabert, Britton, Vogtmann, Emily, and Knight, Robin

Subjects
estrogens, fecal microbiome, oral microbiome, postmenopausal African women, Female, Humans, Estrogens, Postmenopause, RNA, Ribosomal, 16S, Ghana, Breast Neoplasms, Microbiota, Lactobacillales
Abstract

The human fecal and oral microbiome may play a role in the etiology of breast cancer through modulation of endogenous estrogen metabolism. This study aimed to investigate associations of circulating estrogens and estrogen metabolites with the fecal and oral microbiome in postmenopausal African women. A total of 117 women with fecal (N = 110) and oral (N = 114) microbiome data measured by 16S rRNA gene sequencing, and estrogens and estrogen metabolites data measured by liquid chromatography tandem mass spectrometry were included. The outcomes were measures of the microbiome and the independent variables were the estrogens and estrogen metabolites. Estrogens and estrogen metabolites were associated with the fecal microbial Shannon index (global P

Published
2023

6. Gene Expression Profiling Identifies Two Chordoma Subtypes Associated with Distinct Molecular Mechanisms and Clinical Outcomes.

Author

Bai, Jiwei, Shi, Jianxin, Zhang, Yazhuo, Li, Chuzhong, Xiong, Yujia, Koka, Hela, Wang, Difei, Zhang, Tongwu, Song, Lei, Luo, Wen, Zhu, Bin, Hicks, Belynda, Hutchinson, Amy, Kirk, Erin, Troester, Melissa, Li, Mingxuan, Shen, Yutao, Ma, Tianshun, Wang, Junmei, Liu, Xing, Wang, Shuai, Gui, Songbai, McMaster, Mary, Chanock, Stephen, Parry, Dilys, Goldstein, Allen, and Yang, Xiaohong

Subjects
Humans, Chordoma, Hedgehog Proteins, Biomarkers, Tumor, Gene Expression Profiling, Skull Base Neoplasms
Abstract

PURPOSE: Chordoma is a rare bone tumor with a high recurrence rate and limited treatment options. The aim of this study was to identify molecular subtypes of chordoma that may improve clinical management. EXPERIMENTAL DESIGN: We conducted RNA sequencing in 48 tumors from patients with Chinese skull-base chordoma and identified two major molecular subtypes. We then replicated the classification using a NanoString panel in 48 patients with chordoma from North America. RESULTS: Tumors in one subtype were more likely to have somatic mutations and reduced expression in chromatin remodeling genes, such as PBRM1 and SETD2, whereas the other subtype was characterized by the upregulation of genes in epithelial-mesenchymal transition and Sonic Hedgehog pathways. IHC staining of top differentially expressed genes between the two subtypes in 312 patients with Chinese chordoma with long-term follow-up data showed that the expression of some markers such as PTCH1 was significantly associated with survival outcomes. CONCLUSIONS: Our findings may improve the understanding of subtype-specific tumorigenesis of chordoma and inform clinical prognostication and targeted options.

Published
2023

7. Impact of Transcript (p16/p14ARF) Alteration on Cancer Risk in CDKN2A Germline Pathogenic Variant Carriers.

Author

Sargen, Michael R, Helgadottir, Hildur, Yang, Xiaohong R, Harland, Mark, Hatton, Jessica N, Jones, Kristine, Hicks, Belynda D, Hutchinson, Amy, Curry, Michael, Tucker, Margaret A, Goldstein, Alisa M, and Pfeiffer, Ruth M

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Rare Diseases, Digestive Diseases, Lung, Cancer, Prevention, Clinical Research, Humans, United States, Aged, Tumor Suppressor Protein p14ARF, Squamous Cell Carcinoma of Head and Neck, Cyclin-Dependent Kinase Inhibitor p16, Melanoma, Risk Factors, Head and Neck Neoplasms, Oncology and carcinogenesis
Abstract

Few studies have evaluated the relationship between CDKN2A germline pathogenic variants (GPV), transcript (p16/p14ARF) alteration, and cancer risk. Standardized incidence ratios (SIRs) comparing cancer risk with the general population were calculated for 385 CDKN2A GPV carriers from 2 large cohorts (259 United States and 126 Swedish individuals) using Poisson regression; statistical significance was defined as P less than .002 (Bonferroni correction). Cumulative incidence is reported for melanoma and nonmelanoma cancer. Incidence was increased for melanoma (SIR = 159.8, 95% confidence interval [CI] = 132.1 to 193.2), pancreatic cancer (SIR = 24.1, 95% CI = 14.7 to 39.4), head and neck squamous cell carcinoma (SIR = 16.2, 95% CI = 9.5 to 27.6), and lung cancer (SIR = 5.6, 95% CI = 3.4 to 9.1) in GPV carriers. Similar associations were observed with p16 alteration. Combined p16 and p14ARF alteration was associated with increased incidence of esophageal cancer (SIR = 16.7, 95% CI = 5.7 to 48.9) and malignant peripheral nerve sheath tumor (SIR = 113.0, 95% CI = 16.4 to 780.9), although cancer events were limited (n

Published
2022

8. The oral microbiome and breast cancer and nonmalignant breast disease, and its relationship with the fecal microbiome in the Ghana Breast Health Study.

Author

Wu, Zeni, Byrd, Doratha, Wan, Yunhu, Ansong, Daniel, Clegg-Lamptey, Joe-Nat, Wiafe-Addai, Beatrice, Edusei, Lawrence, Adjei, Ernest, Titiloye, Nicholas, Dedey, Florence, Aitpillah, Francis, Oppong, Joseph, Vanderpuye, Verna, Osei-Bonsu, Ernest, Dagnall, Casey, Jones, Kristine, Hutchinson, Amy, Hicks, Belynda, Ahearn, Thomas, Shi, Jianxin, Biritwum, Richard, Yarney, Joel, Wiafe, Seth, Awuah, Baffour, Nyarko, Kofi, Figueroa, Jonine, Sinha, Rashmi, Garcia-Closas, Montserrat, Brinton, Louise, Vogtmann, Emily, and Knight, Robin

Subjects
Ghana, breast cancer, fecal microbiome, nonmalignant breast diseases, oral microbiome, Breast Neoplasms, Case-Control Studies, Feces, Female, Gastrointestinal Microbiome, Ghana, Humans, Logistic Models, Microbiota, Phylogeny, RNA, Ribosomal, 16S
Abstract

The oral microbiome, like the fecal microbiome, may be related to breast cancer risk. Therefore, we investigated whether the oral microbiome was associated with breast cancer and nonmalignant breast disease, and its relationship with the fecal microbiome in a case-control study in Ghana. A total of 881 women were included (369 breast cancers, 93 nonmalignant cases and 419 population-based controls). The V4 region of the 16S rRNA gene was sequenced from oral and fecal samples. Alpha-diversity (observed amplicon sequence variants [ASVs], Shannon index and Faiths Phylogenetic Diversity) and beta-diversity (Bray-Curtis, Jaccard and weighted and unweighted UniFrac) metrics were computed. MiRKAT and logistic regression models were used to investigate the case-control associations. Oral sample alpha-diversity was inversely associated with breast cancer and nonmalignant breast disease with odds ratios (95% CIs) per every 10 observed ASVs of 0.86 (0.83-0.89) and 0.79 (0.73-0.85), respectively, compared to controls. Beta-diversity was also associated with breast cancer and nonmalignant breast disease compared to controls (P ≤ .001). The relative abundances of Porphyromonas and Fusobacterium were lower for breast cancer cases compared to controls. Alpha-diversity and presence/relative abundance of specific genera from the oral and fecal microbiome were strongly correlated among breast cancer cases, but weakly correlated among controls. Particularly, the relative abundance of oral Porphyromonas was strongly, inversely correlated with fecal Bacteroides among breast cancer cases (r = -.37, P ≤ .001). Many oral microbial metrics were strongly associated with breast cancer and nonmalignant breast disease, and strongly correlated with fecal microbiome among breast cancer cases, but not controls.

Published
2022

9. Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma

Author

Purdue, Mark P., Dutta, Diptavo, Machiela, Mitchell J., Gorman, Bryan R., Winter, Timothy, Okuhara, Dayne, Cleland, Sara, Ferreiro-Iglesias, Aida, Scheet, Paul, Liu, Aoxing, Wu, Chao, Antwi, Samuel O., Larkin, James, Zequi, Stênio C., Sun, Maxine, Hikino, Keiko, Hajiran, Ali, Lawson, Keith A., Cárcano, Flavio, Blanchet, Odile, Shuch, Brian, Nepple, Kenneth G., Margue, Gaëlle, Sundi, Debasish, Diver, W. Ryan, Folgueira, Maria A.A.K., van Bokhoven, Adrie, Neffa, Florencia, Brown, Kevin M., Hofmann, Jonathan N., Rhee, Jongeun, Yeager, Meredith, Cole, Nathan R., Hicks, Belynda D., Manning, Michelle R., Hutchinson, Amy A., Rothman, Nathaniel, Huang, Wen-Yi, Linehan, W. Marston, Lori, Adriana, Ferragu, Matthieu, Zidane-Marinnes, Merzouka, Serrano, Sérgio, Magnabosco, Wesley J., BioBank Japan Project Consortium, Vilas, Ana, Decia, Ricardo, Carusso, Florencia, Graham, Laura S., Anderson, Kyra, Bilen, Mehmet A., Arciero, Cletus, Pellegrin, Isabelle, Ricard, Solène, FinnGen, Scelo, Ghislaine, Banks, Rosamonde E., Vasudev, Naveen S., Soomro, Naeem, Stewart, Grant D., Adeyoju, Adebanji, Bromage, Stephen, Hrouda, David, Gibbons, Norma, Patel, Poulam, Sullivan, Mark, Protheroe, Andrew, Nugent, Francesca I., Fournier, Michelle J., Zhang, Xiaoyu, Martin, Lisa J., Komisarenko, Maria, Eisen, Timothy, Cunningham, Sonia A., Connolly, Denise C., Uzzo, Robert G., Zaridze, David, Mukeria, Anush, Holcatova, Ivana, Hornakova, Anna, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Gaborieau, Valérie, Abedi-Ardekani, Behnoush, McKay, James, Johansson, Mattias, Phouthavongsy, Larry, Hayman, Lindsay, Li, Jason, Lungu, Ilinca, Bezerra, Stephania M., de Souza, Aline G., Sares, Claudia T.G., Reis, Rodolfo B., Gallucci, Fabio P., Cordeiro, Mauricio D., Pomerantz, Mark, Lee, Gwo-Shu M., Freedman, Matthew L., Jeong, Anhyo, Greenberg, Samantha E., Sanchez, Alejandro, Thompson, R. Houston, Sharma, Vidit, Thiel, David D., Ball, Colleen T., Abreu, Diego, Lam, Elaine T., Nahas, William C., Master, Viraj A., Patel, Alpa V., Bernhard, Jean-Christophe, Freedman, Neal D., Bigot, Pierre, Reis, Rui M., Colli, Leandro M., Finelli, Antonio, Manley, Brandon J., Terao, Chikashi, Choueiri, Toni K., Carraro, Dirce M., Houlston, Richard, Eckel-Passow, Jeanette E., Abbosh, Philip H., Ganna, Andrea, Brennan, Paul, Gu, Jian, Chanock, Stephen J., Guo, Xinyu, Winter, Timothy D., Jahagirdar, Om, Ha, Eunji, and Susztak, Katalin

Published
2024
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10. Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa

Author

Zhou, Weiyin, Fischer, Anja, Ogwang, Martin D., Luo, Wen, Kerchan, Patrick, Reynolds, Steven J., Tenge, Constance N., Were, Pamela A., Kuremu, Robert T., Wekesa, Walter N., Masalu, Nestory, Kawira, Esther, Kinyera, Tobias, Otim, Isaac, Legason, Ismail D., Nabalende, Hadijah, Ayers, Leona W., Bhatia, Kishor, Goedert, James J., Gouveia, Mateus H., Cole, Nathan, Hicks, Belynda, Jones, Kristine, Hummel, Michael, Schlesner, Mathias, Chagaluka, George, Mutalima, Nora, Borgstein, Eric, Liomba, George N., Kamiza, Steve, Mkandawire, Nyengo, Mitambo, Collins, Molyneux, Elizabeth M., Newton, Robert, Glaser, Selina, Kretzmer, Helene, Manning, Michelle, Hutchinson, Amy, Hsing, Ann W., Tettey, Yao, Adjei, Andrew A., Chanock, Stephen J., Siebert, Reiner, Yeager, Meredith, Prokunina-Olsson, Ludmila, Machiela, Mitchell J., and Mbulaiteye, Sam M.

Published
2023
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11. Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Author

Shi, Jianxin, Shiraishi, Kouya, Choi, Jiyeon, Matsuo, Keitaro, Chen, Tzu-Yu, Dai, Juncheng, Hung, Rayjean J., Chen, Kexin, Shu, Xiao-Ou, Kim, Young Tae, Landi, Maria Teresa, Lin, Dongxin, Zheng, Wei, Yin, Zhihua, Zhou, Baosen, Song, Bao, Wang, Jiucun, Seow, Wei Jie, Song, Lei, Chang, I-Shou, Hu, Wei, Chien, Li-Hsin, Cai, Qiuyin, Hong, Yun-Chul, Kim, Hee Nam, Wu, Yi-Long, Wong, Maria Pik, Richardson, Brian Douglas, Funderburk, Karen M., Li, Shilan, Zhang, Tongwu, Breeze, Charles, Wang, Zhaoming, Blechter, Batel, Bassig, Bryan A., Kim, Jin Hee, Albanes, Demetrius, Wong, Jason Y. Y., Shin, Min-Ho, Chung, Lap Ping, Yang, Yang, An, She-Juan, Zheng, Hong, Yatabe, Yasushi, Zhang, Xu-Chao, Kim, Young-Chul, Caporaso, Neil E., Chang, Jiang, Ho, James Chung Man, Kubo, Michiaki, Daigo, Yataro, Song, Minsun, Momozawa, Yukihide, Kamatani, Yoichiro, Kobayashi, Masashi, Okubo, Kenichi, Honda, Takayuki, Hosgood, Dean H., Kunitoh, Hideo, Patel, Harsh, Watanabe, Shun-ichi, Miyagi, Yohei, Nakayama, Haruhiko, Matsumoto, Shingo, Horinouchi, Hidehito, Tsuboi, Masahiro, Hamamoto, Ryuji, Goto, Koichi, Ohe, Yuichiro, Takahashi, Atsushi, Goto, Akiteru, Minamiya, Yoshihiro, Hara, Megumi, Nishida, Yuichiro, Takeuchi, Kenji, Wakai, Kenji, Matsuda, Koichi, Murakami, Yoshinori, Shimizu, Kimihiro, Suzuki, Hiroyuki, Saito, Motonobu, Ohtaki, Yoichi, Tanaka, Kazumi, Wu, Tangchun, Wei, Fusheng, Dai, Hongji, Machiela, Mitchell J., Su, Jian, Kim, Yeul Hong, Oh, In-Jae, Lee, Victor Ho Fun, Chang, Gee-Chen, Tsai, Ying-Huang, Chen, Kuan-Yu, Huang, Ming-Shyan, Su, Wu-Chou, Chen, Yuh-Min, Seow, Adeline, Park, Jae Yong, Kweon, Sun-Seog, Chen, Kun-Chieh, Gao, Yu-Tang, Qian, Biyun, Wu, Chen, Lu, Daru, Liu, Jianjun, Schwartz, Ann G., Houlston, Richard, Spitz, Margaret R., Gorlov, Ivan P., Wu, Xifeng, Yang, Ping, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Ji, Bu-Tian, Wichmann, H-Erich, Christiani, David C., Rennert, Gadi, Arnold, Susanne, Brennan, Paul, McKay, James, Field, John K., Shete, Sanjay S., Le Marchand, Loic, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Zienolddiny-Narui, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Taylor, Fiona, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Jeon, Hyo-Sung, Jiang, Shih Sheng, Sung, Jae Sook, Chen, Chung-Hsing, Hsiao, Chin-Fu, Jung, Yoo Jin, Guo, Huan, Hu, Zhibin, Burdett, Laurie, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda, Liu, Jia, Zhu, Bin, Berndt, Sonja I., Wu, Wei, Wang, Junwen, Li, Yuqing, Choi, Jin Eun, Park, Kyong Hwa, Sung, Sook Whan, Liu, Li, Kang, Chang Hyun, Wang, Wen-Chang, Xu, Jun, Guan, Peng, Tan, Wen, Yu, Chong-Jen, Yang, Gong, Sihoe, Alan Dart Loon, Chen, Ying, Choi, Yi Young, Kim, Jun Suk, Yoon, Ho-Il, Park, In Kyu, Xu, Ping, He, Qincheng, Wang, Chih-Liang, Hung, Hsiao-Han, Vermeulen, Roel C. H., Cheng, Iona, Wu, Junjie, Lim, Wei-Yen, Tsai, Fang-Yu, Chan, John K. C., Li, Jihua, Chen, Hongyan, Lin, Hsien-Chih, Jin, Li, Liu, Jie, Sawada, Norie, Yamaji, Taiki, Wyatt, Kathleen, Li, Shengchao A., Ma, Hongxia, Zhu, Meng, Wang, Zhehai, Cheng, Sensen, Li, Xuelian, Ren, Yangwu, Chao, Ann, Iwasaki, Motoki, Zhu, Junjie, Jiang, Gening, Fei, Ke, Wu, Guoping, Chen, Chih-Yi, Chen, Chien-Jen, Yang, Pan-Chyr, Yu, Jinming, Stevens, Victoria L., Fraumeni, Jr, Joseph F., Chatterjee, Nilanjan, Gorlova, Olga Y., Hsiung, Chao Agnes, Amos, Christopher I., Shen, Hongbing, Chanock, Stephen J., Rothman, Nathaniel, Kohno, Takashi, and Lan, Qing

Published
2023
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12. DNA methylation age in paired tumor and adjacent normal breast tissue in Chinese women with breast cancer

Author

Koka, Hela, Bodelon, Clara, Horvath, Steve, Lee, Priscilla Ming Yi, Wang, Difei, Song, Lei, Zhang, Tongwu, Hurson, Amber N., Guida, Jennifer Lyn, Zhu, Bin, Bailey-Whyte, Maeve, Wang, Feng, Wu, Cherry, Tsang, Koon Ho, Tsoi, Yee-Kei, Chan, W. C., Law, Sze Hong, Hung, Ray Ka Wai, Tse, Gary M., Yuen, Karen Ka-wan, Karlins, Eric, Jones, Kristine, Vogt, Aurelie, Zhu, Bin, Hutchinson, Amy, Hicks, Belynda, Garcia-Closas, Montserrat, Chanock, Stephen, Barnholtz-Sloan, Jill, Tse, Lap Ah, and Yang, Xiaohong R.

Published
2023
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13. GWAS Explorer: an open-source tool to explore, visualize, and access GWAS summary statistics in the PLCO Atlas

Author

Machiela, Mitchell J., Huang, Wen-Yi, Wong, Wendy, Berndt, Sonja I., Sampson, Joshua, De Almeida, Jonas, Abubakar, Mustapha, Hislop, Jada, Chen, Kai-Ling, Dagnall, Casey, Diaz-Mayoral, Norma, Ferrell, Mary, Furr, Michael, Gonzalez, Alex, Hicks, Belynda, Hubbard, Aubrey K., Hutchinson, Amy, Jiang, Kevin, Jones, Kristine, Liu, Jia, Loftfield, Erikka, Loukissas, Jennifer, Mabie, Jerome, Merkle, Shannon, Miller, Eric, Minasian, Lori M., Nordgren, Ellen, Park, Brian, Pinsky, Paul, Riley, Thomas, Sandoval, Lorena, Saxena, Neeraj, Vogt, Aurelie, Wang, Jiahui, Williams, Craig, Wright, Patrick, Yeager, Meredith, Zhu, Bin, Zhu, Claire, Chanock, Stephen J., Garcia-Closas, Montserrat, and Freedman, Neal D.

Published
2023
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14. Genome-wide Association Study of Bladder Cancer Reveals New Biological and Translational Insights

Author

Koutros, Stella, Kiemeney, Lambertus A., Pal Choudhury, Parichoy, Milne, Roger L., Lopez de Maturana, Evangelina, Ye, Yuanqing, Joseph, Vijai, Florez-Vargas, Oscar, Dyrskjøt, Lars, Figueroa, Jonine, Dutta, Diptavo, Giles, Graham G., Hildebrandt, Michelle A.T., Offit, Kenneth, Kogevinas, Manolis, Weiderpass, Elisabete, McCullough, Marjorie L., Freedman, Neal D., Albanes, Demetrius, Kooperberg, Charles, Cortessis, Victoria K., Karagas, Margaret R., Johnson, Alison, Schwenn, Molly R., Baris, Dalsu, Furberg, Helena, Bajorin, Dean F., Cussenot, Olivier, Cancel-Tassin, Geraldine, Benhamou, Simone, Kraft, Peter, Porru, Stefano, Carta, Angela, Bishop, Timothy, Southey, Melissa C., Matullo, Giuseppe, Fletcher, Tony, Kumar, Rajiv, Taylor, Jack A., Lamy, Philippe, Prip, Frederik, Kalisz, Mark, Weinstein, Stephanie J., Hengstler, Jan G., Selinski, Silvia, Harland, Mark, Teo, Mark, Kiltie, Anne E., Tardón, Adonina, Serra, Consol, Carrato, Alfredo, García-Closas, Reina, Lloreta, Josep, Schned, Alan, Lenz, Petra, Riboli, Elio, Brennan, Paul, Tjønneland, Anne, Otto, Thomas, Ovsiannikov, Daniel, Volkert, Frank, Vermeulen, Sita H., Aben, Katja K., Galesloot, Tessel E., Turman, Constance, De Vivo, Immaculata, Giovannucci, Edward, Hunter, David J., Hohensee, Chancellor, Hunt, Rebecca, Patel, Alpa V., Huang, Wen-Yi, Thorleifsson, Gudmar, Gago-Dominguez, Manuela, Amiano, Pilar, Golka, Klaus, Stern, Mariana C., Yan, Wusheng, Liu, Jia, Li, Shengchao Alfred, Katta, Shilpa, Hutchinson, Amy, Hicks, Belynda, Wheeler, William A., Purdue, Mark P., McGlynn, Katherine A., Kitahara, Cari M., Haiman, Christopher A., Greene, Mark H., Rafnar, Thorunn, Chatterjee, Nilanjan, Chanock, Stephen J., Wu, Xifeng, Real, Francisco X., Silverman, Debra T., Garcia-Closas, Montserrat, Stefansson, Kari, Prokunina-Olsson, Ludmila, Malats, Núria, and Rothman, Nathaniel

Published
2023
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16. Novel MAPK/AKT-impairing germline NRAS variant identified in a melanoma-prone family

Author

Brown, Kevin M., Xu, Mai, Sargen, Michael, Jang, Hyunbum, Zhang, Mingzhen, Zhang, Tongwu, Zhu, Bin, Jones, Kristie, Kim, Jung, Mendoza, Laura, Hayward, Nicholas K., Tucker, Margaret A., Goldstein, Alisa M., Yang, Xiaohong Rose, Stewart, Douglas R., Hicks, Belynda, Consonni, Dario, Pesatori, Angela C., Fargnoli, Maria Concetta, Peris, Ketty, Stratigos, Alex, Menin, Chiara, Ghiorzo, Paola, Puig, Susana, Nagore, Eduardo, Andresson, Thorkell, Nussinov, Ruth, Calista, Donato, and Landi, Maria Teresa

Published
2022
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18. Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis.

Author

Shu, Xiang, Wu, Lang, Khankari, Nikhil K, Shu, Xiao-Ou, Wang, Thomas J, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Milne, Roger L, Schmidt, Marjanka K, Pharoah, Paul DP, Andrulis, Irene L, Hunter, David J, Simard, Jacques, Easton, Douglas F, Zheng, Wei, Alicia, Beeghly-Fadiel J, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Barrdahl, Myrto, Baynes, Caroline, Beane Freeman, Laura E, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Broberg, Per, Brucker, Sara Y, Brüning, Thomas, Burwinkel, Barbara, Cai, Qiuyin, Caldés, Trinidad, Canzian, Federico, Carter, Brian D, Castelao, Jose E, Chang-Claude, Jenny, Chenevix-Trench, Georgia, David Cheng, Ting-Yuan, Clarke, Christine L, Conroy, Don M, Couch, Fergus J, Cox, David G, Cox, Angela, Cross, Simon S, Cunningham, Julie M, Czene, Kamila, Daly, Mary B, Doheny, Kimberly F, Dörk, Thilo, dos-Santos-Silva, Isabel, Dumont, Martine, Dunning, Alison M, Dwek, Miriam, Earp, H Shelton, Eccles, Diana M, Heather Eliassen, A, Engel, Christoph, Eriksson, Mikael, Gareth Evans, D, Fachal, Laura, Fasching, Peter A, Figueroa, Jonine, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, Gapstur, Susan M, García-Closas, Montserrat, Gaudet, Mia M, Ghoussaini, Maya, Giles, Graham G, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hallberg, Emily, Hamann, Ute, Harrington, Patricia, He, Wei, Hein, Alexander, Hicks, Belynda, Hillemanns, Peter, Hogervorst, Frans B, Hollestelle, Antoinette, and Hoover, Robert N

Subjects
Clinical Research, Diabetes, Prevention, Nutrition, Obesity, Cancer, Aging, Breast Cancer, Genetics, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Adult, Aged, Blood Glucose, Body Mass Index, Breast Neoplasms, Diabetes Mellitus, Type 2, Female, Humans, Insulin, Mendelian Randomization Analysis, Middle Aged, Obesity, Abdominal, Waist-Hip Ratio, Breast cancer, insulin, glucose, obesity, genetics, Mendelian randomization analysis, Breast Cancer Association Consortium, Statistics, Public Health and Health Services, Epidemiology
Abstract

BackgroundIn addition to the established association between general obesity and breast cancer risk, central obesity and circulating fasting insulin and glucose have been linked to the development of this common malignancy. Findings from previous studies, however, have been inconsistent, and the nature of the associations is unclear.MethodsWe conducted Mendelian randomization analyses to evaluate the association of breast cancer risk, using genetic instruments, with fasting insulin, fasting glucose, 2-h glucose, body mass index (BMI) and BMI-adjusted waist-hip-ratio (WHRadj BMI). We first confirmed the association of these instruments with type 2 diabetes risk in a large diabetes genome-wide association study consortium. We then investigated their associations with breast cancer risk using individual-level data obtained from 98 842 cases and 83 464 controls of European descent in the Breast Cancer Association Consortium.ResultsAll sets of instruments were associated with risk of type 2 diabetes. Associations with breast cancer risk were found for genetically predicted fasting insulin [odds ratio (OR) = 1.71 per standard deviation (SD) increase, 95% confidence interval (CI) = 1.26-2.31, p  =  5.09  ×  10-4], 2-h glucose (OR = 1.80 per SD increase, 95% CI = 1.3 0-2.49, p  =  4.02  ×  10-4), BMI (OR = 0.70 per 5-unit increase, 95% CI = 0.65-0.76, p  =  5.05  ×  10-19) and WHRadj BMI (OR = 0.85, 95% CI = 0.79-0.91, p  =  9.22  ×  10-6). Stratified analyses showed that genetically predicted fasting insulin was more closely related to risk of estrogen-receptor [ER]-positive cancer, whereas the associations with instruments of 2-h glucose, BMI and WHRadj BMI were consistent regardless of age, menopausal status, estrogen receptor status and family history of breast cancer.ConclusionsWe confirmed the previously reported inverse association of genetically predicted BMI with breast cancer risk, and showed a positive association of genetically predicted fasting insulin and 2-h glucose and an inverse association of WHRadj BMI with breast cancer risk. Our study suggests that genetically determined obesity and glucose/insulin-related traits have an important role in the aetiology of breast cancer.

Published
2019

21. Genetic testing in severe aplastic anemia is required for optimal hematopoietic cell transplant outcomes

Author

McReynolds, Lisa J., Rafati, Maryam, Wang, Youjin, Ballew, Bari J., Kim, Jung, Williams, Valencia V., Zhou, Weiyin, Hendricks, Rachel M., Dagnall, Casey, Freedman, Neal D., Carter, Brian, Strollo, Sara, Hicks, Belynda, Zhu, Bin, Jones, Kristine, Paczesny, Sophie, Marsh, Steven G.E., Spellman, Stephen R., He, Meilun, Wang, Tao, Lee, Stephanie J., Savage, Sharon A., and Gadalla, Shahinaz M.

Published
2022
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22. Germline-somatic JAK2 interactions are associated with clonal expansion in myelofibrosis

Author

Brown, Derek W., Zhou, Weiyin, Wang, Youjin, Jones, Kristine, Luo, Wen, Dagnall, Casey, Teshome, Kedest, Klein, Alyssa, Zhang, Tongwu, Lin, Shu-Hong, Lee, Olivia W., Khan, Sairah, Vo, Jacqueline B., Hutchinson, Amy, Liu, Jia, Wang, Jiahui, Zhu, Bin, Hicks, Belynda, Martin, Andrew St., Spellman, Stephen R., Wang, Tao, Deeg, H. Joachim, Gupta, Vikas, Lee, Stephanie J., Freedman, Neal D., Yeager, Meredith, Chanock, Stephen J., Savage, Sharon A., Saber, Wael, Gadalla, Shahinaz M., and Machiela, Mitchell J.

Published
2022
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23. A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer

Author

Wu, Lang, Shi, Wei, Long, Jirong, Guo, Xingyi, Michailidou, Kyriaki, Beesley, Jonathan, Bolla, Manjeet K, Shu, Xiao-Ou, Lu, Yingchang, Cai, Qiuyin, Al-Ejeh, Fares, Rozali, Esdy, Wang, Qin, Dennis, Joe, Li, Bingshan, Zeng, Chenjie, Feng, Helian, Gusev, Alexander, Barfield, Richard T, Andrulis, Irene L, Anton-Culver, Hoda, Arndt, Volker, Aronson, Kristan J, Auer, Paul L, Barrdahl, Myrto, Baynes, Caroline, Beckmann, Matthias W, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Brauch, Hiltrud, Brenner, Hermann, Brinton, Louise, Broberg, Per, Brucker, Sara Y, Burwinkel, Barbara, Caldés, Trinidad, Canzian, Federico, Carter, Brian D, Castelao, J Esteban, Chang-Claude, Jenny, Chen, Xiaoqing, Cheng, Ting-Yuan David, Christiansen, Hans, Clarke, Christine L, NBCS Collaborators, Collée, Margriet, Cornelissen, Sten, Couch, Fergus J, Cox, David, Cox, Angela, Cross, Simon S, Cunningham, Julie M, Czene, Kamila, Daly, Mary B, Devilee, Peter, Doheny, Kimberly F, Dörk, Thilo, dos-Santos-Silva, Isabel, Dumont, Martine, Dwek, Miriam, Eccles, Diana M, Eilber, Ursula, Eliassen, A Heather, Engel, Christoph, Eriksson, Mikael, Fachal, Laura, Fasching, Peter A, Figueroa, Jonine, Flesch-Janys, Dieter, Fletcher, Olivia, Flyger, Henrik, Fritschi, Lin, Gabrielson, Marike, Gago-Dominguez, Manuela, Gapstur, Susan M, García-Closas, Montserrat, Gaudet, Mia M, Ghoussaini, Maya, Giles, Graham G, Goldberg, Mark S, Goldgar, David E, González-Neira, Anna, Guénel, Pascal, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Hallberg, Emily, Hamann, Ute, Harrington, Patricia, Hein, Alexander, Hicks, Belynda, Hillemanns, Peter, Hollestelle, Antoinette, Hoover, Robert N, Hopper, John L, and Huang, Guanmengqian

Subjects
Biological Sciences, Genetics, Human Genome, Biotechnology, Prevention, Breast Cancer, Women's Health, Cancer Genomics, Cancer, 2.1 Biological and endogenous factors, Generic health relevance, Breast Neoplasms, Case-Control Studies, Female, Gene Expression, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Risk, Transcriptome, NBCS Collaborators, kConFab/AOCS Investigators, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas. Of the 8,597 genes evaluated, significant associations were identified for 48 at a Bonferroni-corrected threshold of P

Published
2018

24. Endemic Burkitt Lymphoma in second-degree relatives in Northern Uganda: in-depth genome-wide analysis suggests clues about genetic susceptibility

Author

Gouveia, Mateus H., Otim, Isaac, Ogwang, Martin D., Wang, Mingyi, Zhu, Bin, Cole, Nathan, Luo, Wen, Hicks, Belynda, Jones, Kristine, Oehl-Huber, Kathrin, Ayers, Leona W., Pittaluga, Stefania, Legason, Ismail D., Nabalende, Hadijah, Kerchan, Patrick, Kinyera, Tobias, Kawira, Esther, Brubaker, Glen, Levin, Arthur G., Guertler, Lutz, Kim, Jung, Stewart, Douglas R., Adde, Melissa, Magrath, Ian, Bergen, Andrew W., Reynolds, Steven J., Yeager, Meredith, Bhatia, Kishor, Adeyemo, Adebowale A., Prokunina-Olsson, Ludmila, Dean, Michael, Shriner, Daniel, Rotimi, Charles N., Chanock, Stephen, Siebert, Reiner, and Mbulaiteye, Sam M.

Published
2021
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25. Genomic characterization of cervical lymph node metastases in papillary thyroid carcinoma following the Chornobyl accident.

Author

Morton, Lindsay M., Lee, Olivia W., Karyadi, Danielle M., Bogdanova, Tetiana I., Stewart, Chip, Hartley, Stephen W., Breeze, Charles E., Schonfeld, Sara J., Cahoon, Elizabeth K., Drozdovitch, Vladimir, Masiuk, Sergii, Chepurny, Mykola, Zurnadzhy, Liudmyla Yu, Dai, Jieqiong, Krznaric, Marko, Yeager, Meredith, Hutchinson, Amy, Hicks, Belynda D., Dagnall, Casey L., and Steinberg, Mia K.

Subjects
IODINE isotopes, LYMPHATIC metastasis, PAPILLARY carcinoma, THYROID cancer, GENETIC profile, GENOMICS
Abstract

Childhood radioactive iodine exposure from the Chornobyl accident increased papillary thyroid carcinoma (PTC) risk. While cervical lymph node metastases (cLNM) are well-recognized in pediatric PTC, the PTC metastatic process and potential radiation association are poorly understood. Here, we analyze cLNM occurrence among 428 PTC with genomic landscape analyses and known drivers (131I-exposed = 349, unexposed = 79; mean age = 27.9 years). We show that cLNM are more frequent in PTC with fusion (55%) versus mutation (30%) drivers, although the proportion varies by specific driver gene (RET-fusion = 71%, BRAF-mutation = 38%, RAS-mutation = 5%). cLNM frequency is not associated with other characteristics, including radiation dose. cLNM molecular profiling (N = 47) demonstrates 100% driver concordance with matched primary PTCs and highly concordant mutational spectra. Transcriptome analysis reveals 17 differentially expressed genes, particularly in the HOXC cluster and BRINP3; the strongest differentially expressed microRNA also is near HOXC10. Our findings underscore the critical role of driver alterations and provide promising candidates for elucidating the biological underpinnings of PTC cLNM. Childhood radioactive iodine exposure from the Chornobyl accident led to an increased papillary thyroid carcinoma (PTC) risk and potentially higher invasiveness depending on tumour genetic profiles. Here, the authors use genomics to characterise and predict cervical lymph node metastases in PTC patients affected by the Chornobyl accident. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Monoallelic Germline Pathogenic Variants in DNA Damage Repair Genes and Their Impact on Post-Hematopoietic Cell Transplantation Outcomes in Severe Aplastic Anemia

Author

Rafati, Maryam, primary, Wang, Youjin, additional, McReynolds, Lisa J., additional, Jones, Kristine, additional, Hicks, Belynda, additional, Spellman, Stephen R., additional, He, Meilun, additional, Bolon, Yung-Tsi, additional, Lee, Stephanie J., additional, Savage, Sharon A., additional, and Gadalla, Shahinaz M., additional

Published
2024
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29. Human leukocyte antigen-DQA1*04:01 and rs2040406 variants are associated with elevated risk of childhood Burkitt lymphoma

Author

Liu, Zhiwei, primary, Luo, Yang, additional, Kirimunda, Samuel, additional, Verboom, Murielle, additional, Onabajo, Olusegun O., additional, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Cole, Nathan, additional, Luo, Wen, additional, Liu, Jia, additional, Manning, Michelle, additional, Hicks, Belynda, additional, Prokunina-Olsson, Ludmila, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hsing, Ann W., additional, Mensah, James E., additional, Adjei, Anthony A., additional, Hutchinson, Amy, additional, Carrington, Mary, additional, Yeager, Meredith, additional, Blasczyk, Rainer, additional, Chanock, Stephen J., additional, Raychaudhuri, Soumya, additional, and Mbulaiteye, Sam M., additional

Published
2024
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30. Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

Author

Machiela, Mitchell J, Zhou, Weiyin, Karlins, Eric, Sampson, Joshua N, Freedman, Neal D, Yang, Qi, Hicks, Belynda, Dagnall, Casey, Hautman, Christopher, Jacobs, Kevin B, Abnet, Christian C, Aldrich, Melinda C, Amos, Christopher, Amundadottir, Laufey T, Arslan, Alan A, Beane-Freeman, Laura E, Berndt, Sonja I, Black, Amanda, Blot, William J, Bock, Cathryn H, Bracci, Paige M, Brinton, Louise A, Bueno-de-Mesquita, H Bas, Burdett, Laurie, Buring, Julie E, Butler, Mary A, Canzian, Federico, Carreon, Tania, Chaffee, Kari G, Chang, I-Shou, Chatterjee, Nilanjan, Chen, Chu, Chen, Constance, Chen, Kexin, Chung, Charles C, Cook, Linda S, Bou, Marta Crous, Cullen, Michael, Davis, Faith G, De Vivo, Immaculata, Ding, Ti, Doherty, Jennifer, Duell, Eric J, Epstein, Caroline G, Fan, Jin-Hu, Figueroa, Jonine D, Fraumeni, Joseph F, Friedenreich, Christine M, Fuchs, Charles S, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M, Garcia-Closas, Montserrat, Gaudet, Mia M, Gaziano, J Michael, Giles, Graham G, Gillanders, Elizabeth M, Giovannucci, Edward L, Goldin, Lynn, Goldstein, Alisa M, Haiman, Christopher A, Hallmans, Goran, Hankinson, Susan E, Harris, Curtis C, Henriksson, Roger, Holly, Elizabeth A, Hong, Yun-Chul, Hoover, Robert N, Hsiung, Chao A, Hu, Nan, Hu, Wei, Hunter, David J, Hutchinson, Amy, Jenab, Mazda, Johansen, Christoffer, Khaw, Kay-Tee, Kim, Hee Nam, Kim, Yeul Hong, Kim, Young Tae, Klein, Alison P, Klein, Robert, Koh, Woon-Puay, Kolonel, Laurence N, Kooperberg, Charles, Kraft, Peter, Krogh, Vittorio, Kurtz, Robert C, LaCroix, Andrea, Lan, Qing, Landi, Maria Teresa, Le Marchand, Loic, Li, Donghui, Liang, Xiaolin, Liao, Linda M, Lin, Dongxin, Liu, Jianjun, Lissowska, Jolanta, Lu, Lingeng, Magliocco, Anthony M, and Malats, Nuria

Published
2016

31. Whole genome sequencing of skull-base chordoma reveals genomic alterations associated with recurrence and chordoma-specific survival

Author

Bai, Jiwei, Shi, Jianxin, Li, Chuzhong, Wang, Shuai, Zhang, Tongwu, Hua, Xing, Zhu, Bin, Koka, Hela, Wu, Ho-Hsiang, Song, Lei, Wang, Difei, Wang, Mingyi, Zhou, Weiyin, Ballew, Bari J., Zhu, Bin, Hicks, Belynda, Mirabello, Lisa, Parry, Dilys M., Zhai, Yixuan, Li, Mingxuan, Du, Jiang, Wang, Junmei, Zhang, Shuheng, Liu, Qian, Zhao, Peng, Gui, Songbai, Goldstein, Alisa M., Zhang, Yazhuo, and Yang, Xiaohong R.

Published
2021
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32. Genome-wide association meta-analyses combining multiple risk phenotypes provide insights into the genetic architecture of cutaneous melanoma susceptibility

Author

Landi, Maria Teresa, Bishop, D. Timothy, MacGregor, Stuart, Machiela, Mitchell J., Stratigos, Alexander J., Ghiorzo, Paola, Brossard, Myriam, Calista, Donato, Choi, Jiyeon, Fargnoli, Maria Concetta, Zhang, Tongwu, Rodolfo, Monica, Trower, Adam J., Menin, Chiara, Martinez, Jacobo, Hadjisavvas, Andreas, Song, Lei, Stefanaki, Irene, Scolyer, Richard, Yang, Rose, Goldstein, Alisa M., Potrony, Miriam, Kypreou, Katerina P., Pastorino, Lorenza, Queirolo, Paola, Pellegrini, Cristina, Cattaneo, Laura, Zawistowski, Matthew, Gimenez-Xavier, Pol, Rodriguez, Arantxa, Elefanti, Lisa, Manoukian, Siranoush, Rivoltini, Licia, Smith, Blair H., Loizidou, Maria A., Del Regno, Laura, Massi, Daniela, Mandala, Mario, Khosrotehrani, Kiarash, Akslen, Lars A., Amos, Christopher I., Andresen, Per A., Avril, Marie-Françoise, Azizi, Esther, Soyer, H. Peter, Bataille, Veronique, Dalmasso, Bruna, Bowdler, Lisa M., Burdon, Kathryn P., Chen, Wei V., Codd, Veryan, Craig, Jamie E., Dębniak, Tadeusz, Falchi, Mario, Fang, Shenying, Friedman, Eitan, Simi, Sarah, Galan, Pilar, Garcia-Casado, Zaida, Gillanders, Elizabeth M., Gordon, Scott, Green, Adele, Gruis, Nelleke A., Hansson, Johan, Harland, Mark, Harris, Jessica, Helsing, Per, Henders, Anjali, Hočevar, Marko, Höiom, Veronica, Hunter, David, Ingvar, Christian, Kumar, Rajiv, Lang, Julie, Lathrop, G. Mark, Lee, Jeffrey E., Li, Xin, Lubiński, Jan, Mackie, Rona M., Malt, Maryrose, Malvehy, Josep, McAloney, Kerrie, Mohamdi, Hamida, Molven, Anders, Moses, Eric K., Neale, Rachel E., Novaković, Srdjan, Nyholt, Dale R., Olsson, Håkan, Orr, Nicholas, Fritsche, Lars G., Puig-Butille, Joan Anton, Qureshi, Abrar A., Radford-Smith, Graham L., Randerson-Moor, Juliette, Requena, Celia, Rowe, Casey, Samani, Nilesh J., Sanna, Marianna, Schadendorf, Dirk, Schulze, Hans-Joachim, Simms, Lisa A., Smithers, Mark, Song, Fengju, Swerdlow, Anthony J., van der Stoep, Nienke, Kukutsch, Nicole A., Visconti, Alessia, Wallace, Leanne, Ward, Sarah V., Wheeler, Lawrie, Sturm, Richard A., Hutchinson, Amy, Jones, Kristine, Malasky, Michael, Vogt, Aurelie, Zhou, Weiyin, Pooley, Karen A., Elder, David E., Han, Jiali, Hicks, Belynda, Hayward, Nicholas K., Kanetsky, Peter A., Brummett, Chad, Montgomery, Grant W., Olsen, Catherine M., Hayward, Caroline, Dunning, Alison M., Martin, Nicholas G., Evangelou, Evangelos, Mann, Graham J., Long, Georgina, Pharoah, Paul D. P., Easton, Douglas F., Barrett, Jennifer H., Cust, Anne E., Abecasis, Goncalo, Duffy, David L., Whiteman, David C., Gogas, Helen, De Nicolo, Arcangela, Tucker, Margaret A., Newton-Bishop, Julia A., Peris, Ketty, Chanock, Stephen J., Demenais, Florence, Brown, Kevin M., Puig, Susana, Nagore, Eduardo, Shi, Jianxin, Iles, Mark M., and Law, Matthew H.

Published
2020
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33. Gene-Level Associations in Patients With and Without Pathogenic Germline Variants in CDKN2A and Pancreatic Cancer

Author

Astiazaran-Symonds, Esteban, Graham, Cole, Kim, Jung, Tucker, Margaret A., Ingvar, Christian, Helgadottir, Hildur, Pastorino, Lorenza, van Doorn, Remco, Sampson, Joshua N., Zhu, Bin, Bruno, William, Queirolo, Paola, Fornarini, Giuseppe, Sciallero, Stefania, Carter, Brian, Hicks, Belynda, Hutchinson, Amy, Jones, Kristine, Stewart, Douglas R., Chanock, Stephen J., Freedman, Neal D., Landi, Maria Teresa, Höiom, Veronica, Puig, Susana, Gruis, Nelleke, Yang, Xiaohong R., Ghiorzo, Paola, and Goldstein, Alisa M.

Published
2022
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34. Sickle cell allele HBB‐rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa

Author

Hong, Hyokyoung G., primary, Gouveia, Mateus H., additional, Ogwang, Martin D., additional, Kerchan, Patrick, additional, Reynolds, Steven J., additional, Tenge, Constance N., additional, Were, Pamela A., additional, Kuremu, Robert T., additional, Wekesa, Walter N., additional, Masalu, Nestory, additional, Kawira, Esther, additional, Kinyera, Tobias, additional, Wang, Xunde, additional, Zhou, Jiefu, additional, Leal, Thiago Peixoto, additional, Otim, Isaac, additional, Legason, Ismail D., additional, Nabalende, Hadijah, additional, Dhudha, Herry, additional, Mumia, Mediatrix, additional, Baker, Francine S., additional, Okusolubo, Temiloluwa, additional, Ayers, Leona W., additional, Bhatia, Kishor, additional, Goedert, James J., additional, Woo, Joshua, additional, Manning, Michelle, additional, Cole, Nathan, additional, Luo, Wen, additional, Hicks, Belynda, additional, Chagaluka, George, additional, Johnston, W. Thomas, additional, Mutalima, Nora, additional, Borgstein, Eric, additional, Liomba, George N., additional, Kamiza, Steve, additional, Mkandawire, Nyengo, additional, Mitambo, Collins, additional, Molyneux, Elizabeth M., additional, Newton, Robert, additional, Hutchinson, Amy, additional, Yeager, Meredith, additional, Adeyemo, Adebowale A., additional, Thein, Swee Lay, additional, Rotimi, Charles N., additional, Chanock, Stephen J., additional, Prokunina‐Olsson, Ludmila, additional, and Mbulaiteye, Sam M., additional

Published
2023
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37. Loci associated with skin pigmentation identified in African populations

Author

Crawford, Nicholas G., Kelly, Derek E., Hansen, Matthew E. B., Beltrame, Marcia H., Fan, Shaohua, Bowman, Shanna L., Jewett, Ethan, Ranciaro, Alessia, Thompson, Simon, Lo, Yancy, Pfeifer, Susanne P., Jensen, Jeffrey D., Campbell, Michael C., Beggs, William, Hormozdiari, Farhad, Mpoloka, Sununguko Wata, Mokone, Gaonyadiwe George, Nyambo, Thomas, Meskel, Dawit Wolde, Belay, Gurja, Haut, Jake, Rothschild, Harriet, Zon, Leonard, Zhou, Yi, Kovacs, Michael A., Xu, Mai, Zhang, Tongwu, Bishop, Kevin, Sinclair, Jason, Rivas, Cecilia, Elliot, Eugene, Choi, Jiyeon, Li, Shengchao A., Hicks, Belynda, Burgess, Shawn, Abnet, Christian, Watkins-Chow, Dawn E., Oceana, Elena, Song, Yun S., Eskin, Eleazar, Brown, Kevin M., Marks, Michael S., Loftus, Stacie K., Pavan, William J., Yeager, Meredith, Chanock, Stephen, and Tishkoff, Sarah A.

Published
2017

39. The genomic and epigenomic evolutionary history of papillary renal cell carcinomas

Author

Zhu, Bin, Poeta, Maria Luana, Costantini, Manuela, Zhang, Tongwu, Shi, Jianxin, Sentinelli, Steno, Zhao, Wei, Pompeo, Vincenzo, Cardelli, Maurizio, Alexandrov, Boian S., Otlu, Burcak, Hua, Xing, Jones, Kristine, Brodie, Seth, Dabrowska, Malgorzata Ewa, Toro, Jorge R., Yeager, Meredith, Wang, Mingyi, Hicks, Belynda, Alexandrov, Ludmil B., Brown, Kevin M., Wedge, David C., Chanock, Stephen, Fazio, Vito Michele, Gallucci, Michele, and Landi, Maria Teresa

Published
2020
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41. Immune gene expression profiling reveals heterogeneity in luminal breast tumors

Author

Zhu, Bin, Tse, Lap Ah, Wang, Difei, Koka, Hela, Zhang, Tongwu, Abubakar, Mustapha, Lee, Priscilla, Wang, Feng, Wu, Cherry, Tsang, Koon Ho, Chan, Wing-cheong, Law, Sze Hong, Li, Mengjie, Li, Wentao, Wu, Suyang, Liu, Zhiguang, Huang, Bixia, Zhang, Han, Tang, Eric, Kan, Zhengyan, Lee, Soohyeon, Park, Yeon Hee, Nam, Seok Jin, Wang, Mingyi, Sun, Xuezheng, Jones, Kristine, Zhu, Bin, Hutchinson, Amy, Hicks, Belynda, Prokunina-Olsson, Ludmila, Shi, Jianxin, Garcia-Closas, Montserrat, Chanock, Stephen, and Yang, Xiaohong R.

Published
2019
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43. No association between donor telomere length and outcomes after allogeneic unrelated hematopoietic cell transplant in patients with acute leukemia

Author

Gadalla, Shahinaz M., Wang, Tao, Loftus, David, Friedman, Lyssa, Dagnall, Casey, Haagenson, Michael, Spellman, Stephen R., Buturovic, Ljubomir, Blauwkamp, Marsha, Shelton, Jason, Fleischhauer, Katharina, Hsu, Katharine C., Verneris, Michael R., Krstajic, Damjan, Hicks, Belynda, Jones, Kristine, Lee, Stephanie J., and Savage, Sharon A.

Published
2018
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45. Evaluation of alcohol-free mouthwash for studies of the oral microbiome

Author

Yano, Yukiko, primary, Vogtmann, Emily, additional, Shreves, Alaina H., additional, Weinstein, Stephanie J., additional, Black, Amanda, additional, Diaz-Mayoral, Norma, additional, Wan, Yunhu, additional, Zhou, Weiyin, additional, Hua, Xing, additional, Dagnall, Casey L., additional, Hutchinson, Amy, additional, Jones, Kristine, additional, Hicks, Belynda D., additional, Wyatt, Kathleen, additional, Brotzman, Michelle, additional, Gerlanc, Nicole, additional, Huang, Wen-Yi, additional, Albert, Paul S., additional, Wentzensen, Nicolas, additional, and Abnet, Christian C., additional

Published
2023
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46. Abstract 3055: Associations of the mucosal microbiome and circulating bile acids with colorectal adenoma among average-risk women

Author

Gomez, Maria F., primary, Byrd, Doratha A., additional, Hogue, Stephanie R., additional, Burns, Jessica R., additional, Smith, Nathan, additional, Sampson, Joshua, additional, Loftfield, Erikka, additional, Warner, Andrew, additional, Dagnall, Casey, additional, Jones, Kristine, additional, Hicks, Belynda, additional, Wan, Yunhu, additional, Kim, Youngchul, additional, Xu, Jin, additional, Sinha, Rashmi, additional, and Vogtmann, Emily, additional

Published
2023
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47. Data from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
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48. Supplementary Table 3 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
Full Text
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49. Supplementary Table 1 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
Full Text
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50. Supplementary Table 6 from A Genome-Wide Scan Identifies Variants in NFIB Associated with Metastasis in Patients with Osteosarcoma

Author

Mirabello, Lisa, primary, Koster, Roelof, primary, Moriarity, Branden S., primary, Spector, Logan G., primary, Meltzer, Paul S., primary, Gary, Joy, primary, Machiela, Mitchell J., primary, Pankratz, Nathan, primary, Panagiotou, Orestis A., primary, Largaespada, David, primary, Wang, Zhaoming, primary, Gastier-Foster, Julie M., primary, Gorlick, Richard, primary, Khanna, Chand, primary, de Toledo, Silvia Regina Caminada, primary, Petrilli, Antonio S., primary, Patiño-Garcia, Ana, primary, Sierrasesúmaga, Luis, primary, Lecanda, Fernando, primary, Andrulis, Irene L., primary, Wunder, Jay S., primary, Gokgoz, Nalan, primary, Serra, Massimo, primary, Hattinger, Claudia, primary, Picci, Piero, primary, Scotlandi, Katia, primary, Flanagan, Adrienne M., primary, Tirabosco, Roberto, primary, Amary, Maria Fernanda, primary, Halai, Dina, primary, Ballinger, Mandy L., primary, Thomas, David M., primary, Davis, Sean, primary, Barkauskas, Donald A., primary, Marina, Neyssa, primary, Helman, Lee, primary, Otto, George M., primary, Becklin, Kelsie L., primary, Wolf, Natalie K., primary, Weg, Madison T., primary, Tucker, Margaret, primary, Wacholder, Sholom, primary, Fraumeni, Joseph F., primary, Caporaso, Neil E., primary, Boland, Joseph F., primary, Hicks, Belynda D., primary, Vogt, Aurelie, primary, Burdett, Laurie, primary, Yeager, Meredith, primary, Hoover, Robert N., primary, Chanock, Stephen J., primary, and Savage, Sharon A., primary

Published
2023
Full Text
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