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138 results on '"Hond, Elly Den"'

1. PFAS Association with Kisspeptin and Sex Hormones in Teenagers of the HBM4EU Aligned Studies

Author

Rodríguez-Carrillo, Andrea, primary, Remy, Silvie, additional, Koppen, Gudrun, additional, Wauters, Natasha, additional, Freire, Carmen, additional, Olivas-Martínez, Alicia, additional, Schillemans, Tessa, additional, Akesson, Agneta, additional, Desalegn, Anteneh, additional, Iszatt, Nina, additional, Hond, Elly den, additional, Verheyen, Veerle J., additional, Fábelová, Lucia, additional, Murinova, Lubica Palkovicova, additional, Díaz, Susana Pedraza, additional, Castano, Argelia, additional, García-Lario, José Vicente, additional, Cox, Bianca, additional, Govarts, Eva, additional, Baken, Kirsten, additional, Tena-Sempere, Manuel, additional, Olea, Nicolás, additional, Schoeters, Greet, additional, and Fernández, Mariana F., additional

Published
2023
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2. Information needs of parents of children with congenital anomalies across Europe: a EUROlinkCAT survey

Author

Marcus, Elena, primary, Latos-Bielenska, Anna, additional, Jamry-Dziurla, Anna, additional, Barišić, Ingeborg, additional, Cavero-Carbonell, Clara, additional, Hond, Elly Den, additional, Garne, Ester, additional, Genard, Lucas, additional, Santos, Ana João, additional, Lutke, L Renée, additional, Dias, Carlos Matias, additional, Pedersen, Christina Neergaard, additional, Neville, Amanda J, additional, Niemann, Annika, additional, Odak, Ljubica, additional, Pierini, Anna, additional, Rico, Juan, additional, Rissmann, Anke, additional, Rankin, Judith, additional, and Morris, Joan K, additional

Published
2022
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4. Intrauterine exposure to environmental pollutants and body mass index during the first 3 years of life

Author

Verhulst, Stijn L., Nelen, Vera, Hond, Elly Den, Koppen, Gudrun, Beunckens, Caroline, Vael, Carl, Schoeters, Greet, and Desager, Kristine

Subjects
Prenatal drug exposure -- Health aspects, Prenatal drug exposure -- Research, Body mass index -- Environmental aspects, Body mass index -- Research, Body mass index -- Health aspects, Obesity in children -- Causes of, Obesity in children -- Research, Obesity in children -- Genetic aspects, Obesity in children -- Environmental aspects, Children -- Health aspects, Children -- Environmental aspects, Children -- Research
Abstract

OBJECTIVE: We investigated the association between body mass index (BMI) standard deviation score (SDS) and prenatal exposure to hexachlorobenzene, dichlorodiphenyldichloroethylene (DDE), dioxin-like compounds, and polychlorinated biphenyls (PCBs). METHODS: In this [...]

Published
2009

5. Sex-specific associations between particulate matter exposure and gene expression in independent discovery and validation cohorts of middle-aged men and women

Author

Vrijens, Karen, Winckelmans, Ellen, Tsamou, Maria, Baeyens, Willy, De Boever, Patrick, Jennen, Danyel, de Kok, Theo M., Hond, Elly Den, Lefebvre, Wouter, Plusquin, Michelle, Reynders, Hans, Schoeters, Greet, Van Larebeke, Nicolas, Vanpoucke, Charlotte, Kleinjans, Jos, and Nawrot, Tim S.

Subjects
Air pollution -- Analysis, Gene expression -- Genetic aspects -- Analysis, Environmental issues, Health
Abstract

BACKGROUND: Particulate matter (PM) exposure leads to premature death, mainly due to respiratory and cardiovascular diseases. OBJECTIVES: Identification of transcriptomic biomarkers of air pollution exposure and effect in a healthy adult population. METHODS: Microarray analyses were performed in 98 healthy volunteers (48 men, 50 women). The expression of eight sex-specific candidate biomarker genes (significantly associated with [PM.sub.10] in the discovery cohort and with a reported link to air pollution-related disease) was measured with qPCR in an independent validation cohort (75 men, 94 women). Pathway analysis was performed using Gene Set Enrichment Analysis. Average daily [PM.sub.2.5] and [PM.sub.10] exposures over 2-years were estimated for each participant's residential address using spatiotemporal interpolation in combination with a dispersion model. RESULTS: Average long-term [PM.sub.10] was 25.9 ([+ or -] 5.4) and 23.7 ([+ or -] 2.3) [micro]g/[m.sup.3] in the discovery and validation cohorts, respectively. In discovery analysis, associations between [PM.sub.10] and the expression of individual genes differed by sex. In the validation cohort, long-term [PM.sub.10] was associated with the expression of DNAJB5 and EAPP in men and ARHGAP4 (p = 0.053) in women. AKAP6 and LIMK1 were significantly associated with [PM.sub.10] in women, although associations differed in direction between the discovery and validation cohorts. Expression of the eight candidate genes in the discovery cohort differentiated between validation cohort participants with high versus low [PM.sub.10] exposure (area under the receiver operating curve = 0.92; 95% CI: 0.85, 1.00; p = 0.0002 in men, 0.86; 95% CI: 0.76, 0.96; p = 0.004 in women). CONCLUSIONS: Expression of the sex-specific candidate genes identified in the discovery population predicted [PM.sub.10] exposure in an independent cohort of adults from the same area. Confirmation in other populations may further support this as a new approach for exposure assessment, and may contribute to the discovery of molecular mechanisms for PM-induced health effects., Background Particulate matter (PM) is a complex mixture of small particles and liquid droplets that contains a number of components, including acids, organic chemicals, metals, and soil or dust particles. [...]

Published
2017
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6. Antihypertensive treatment based on blood pressure measurement at home or in the physician's office

Author

Staessen, Jan A., Hond, Elly Den, Celis, Hilde, Fagard, Robert, Keary, Louis, Vandenhoven, Guy, and O'Brien, Eoin T.

Subjects
Blood pressure -- Measurement, Blood pressure -- Economic aspects, Physician services utilization -- Evaluation, Self-examination, Medical -- Influence
Abstract

Self-measurement of blood pressure (BP) at home is less expensive in comparison with ambulatory monitoring. If applied in a standardized way, self-measurement accomplishes several advantages of ambulatory monitoring and may lead to fewer clinic visits.

Published
2004

7. Chapter 2F. The Flemish Environment and Health Study (FLEHS)– Second Survey (2007–2011): Establishing Reference Values for Biomarkers of Exposure in the Flemish Population

Author

Schoeters, Greet, primary, Colles, Ann, additional, Hond, Elly Den, additional, Croes, Kim, additional, Vrijens, Jan, additional, Baeyens, Willy, additional, Nelen, Vera, additional, Mieroop, Els Van De, additional, Covaci, Adrian, additional, Bruckers, Liesbeth, additional, Larebeke, Nicolas Van, additional, Sioen, Isabelle, additional, Morrens, Bert, additional, and Loots, Ilse, additional

Published
2011
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12. MOESM1 of Cord blood leptin and insulin levels in association with mitochondrial DNA content

Author

Vriens, Annette, Plusquin, Michelle, Baeyens, Willy, Bruckers, Liesbeth, Hond, Elly Den, Loots, Ilse, Nelen, Vera, Schoeters, Greet, Janssen, Bram, and Nawrot, Tim

Abstract

Additional file 1: Figure S1. Flow chart on the included observations. Table S1. The association between metabolic factors and mitochondrial DNA content. Figure S2. Correlation plot of mtDNA content and insulin levels, for boys and girls separately.

Published
2018
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14. Delayed sexual development in adolescents

Author

Roels, Harry, Vanderschueren, Dirk, Hoppenbrouwers, Karel, Staessen, Jan A, Hond, Elly Den, Comhaire, Frank, Kaufman, Jean Marc, and Dhooge, Willem

Subjects
Reproductive organs, Male -- Growth, Polychlorinated biphenyls -- Physiological aspects
Published
2001

15. Policy recommendations and cost implications for a more sustainable framework for European human biomonitoring surveys

Author

Joas, Anke, Knudsen, Lisbeth E., Kolossa-Gehring, Marike, Sepai, Ovnair, Casteleyn, Ludwine, Schoeters, Greet, Angerer, Jürgen, Castaño, Argelia, Aerts, Dominique, Biot, Pierre, Horvat, Milena, Bloemen, Louis, Reis, M Fátima, Lupsa, Ioana-Rodica, Katsonouri, Andromachi, Cerna, Milena, Berglund, Marika, Crettaz, Pierre, Rudnai, Peter, Halzlova, Katarina, Mulcahy, Maurice, Gutleb, Arno C, Fischer, Marc E, Becher, Georg, Fréry, Nadine, Jensen, Genon, Van Vliet, Lisette, Koch, Holger M, Hond, Elly Den, Fiddicke, Ulrike, Esteban, Marta, Exley, Karen, Schwedler, Gerda, Seiwert, Margarete, Ligocka, Danuta, Hohenblum, Philipp, Kyrtopoulos, Soterios, Botsivali, Maria, DeFelip, Elena, Guillou, Claude, Reniero, Fabiano, Grazuleviciene, Regina, Veidebaum, Toomas, Mørck, Thit A, Nielsen, Jeanette K S, Jensen, Janne F, Rivas, Teresa C, Sanchez, Jinny, Koppen, Gudrun, Smolders, Roel, Kozepesy, Szilvia, Hadjipanayis, Adamos, Krskova, Andrea, Mannion, Rory, Jakubowski, Marek, Fucic, J Aleksandra, Pereira-Miguel, Jose, Gurzau, Anca E, Jajcaj, Michal, Mazej, Darja, Tratnik, Janja Snoj, Lehmann, Andrea, Larsson, Kristin, Dumez, Birgit, Joas, Reinhard, Joas, Anke, Knudsen, Lisbeth E., Kolossa-Gehring, Marike, Sepai, Ovnair, Casteleyn, Ludwine, Schoeters, Greet, Angerer, Jürgen, Castaño, Argelia, Aerts, Dominique, Biot, Pierre, Horvat, Milena, Bloemen, Louis, Reis, M Fátima, Lupsa, Ioana-Rodica, Katsonouri, Andromachi, Cerna, Milena, Berglund, Marika, Crettaz, Pierre, Rudnai, Peter, Halzlova, Katarina, Mulcahy, Maurice, Gutleb, Arno C, Fischer, Marc E, Becher, Georg, Fréry, Nadine, Jensen, Genon, Van Vliet, Lisette, Koch, Holger M, Hond, Elly Den, Fiddicke, Ulrike, Esteban, Marta, Exley, Karen, Schwedler, Gerda, Seiwert, Margarete, Ligocka, Danuta, Hohenblum, Philipp, Kyrtopoulos, Soterios, Botsivali, Maria, DeFelip, Elena, Guillou, Claude, Reniero, Fabiano, Grazuleviciene, Regina, Veidebaum, Toomas, Mørck, Thit A, Nielsen, Jeanette K S, Jensen, Janne F, Rivas, Teresa C, Sanchez, Jinny, Koppen, Gudrun, Smolders, Roel, Kozepesy, Szilvia, Hadjipanayis, Adamos, Krskova, Andrea, Mannion, Rory, Jakubowski, Marek, Fucic, J Aleksandra, Pereira-Miguel, Jose, Gurzau, Anca E, Jajcaj, Michal, Mazej, Darja, Tratnik, Janja Snoj, Lehmann, Andrea, Larsson, Kristin, Dumez, Birgit, and Joas, Reinhard

Abstract

The potential of Human Biomonitoring (HBM) in exposure characterisation and risk assessment is well established in the scientific HBM community and regulatory arena by many publications. The European Environment and Health Strategy as well as the Environment and Health Action Plan 2004-2010 of the European Commission recognised the value of HBM and the relevance and importance of coordination of HBM programmes in Europe. Based on existing and planned HBM projects and programmes of work and capabilities in Europe the Seventh Framework Programme (FP 7) funded COPHES (COnsortium to Perform Human Biomonitoring on a European Scale) to advance and improve comparability of HBM data across Europe. The pilot study protocol was tested in 17 European countries in the DEMOCOPHES feasibility study (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale) cofunded (50%) under the LIFE+ programme of the European Commission. The potential of HBM in supporting and evaluating policy making (including e.g. REACH) and in awareness raising on environmental health, should significantly advance the process towards a fully operational, continuous, sustainable and scientifically based EU HBM programme. From a number of stakeholder activities during the past 10 years and the national engagement, a framework for sustainable HBM structure in Europe is recommended involving national institutions within environment, health and food as well as European institutions such as ECHA, EEA, and EFSA. An economic frame with shared cost implications for national and European institutions is suggested benefitting from the capacity building set up by COPHES/DEMOCOPHES.

Published
2015

16. Lessons learnt on recruitment and fieldwork from a pilot European human biomonitoring survey

Author

Fiddicke, Ulrike, Becker, Kerstin, Schwedler, Gerda, Seiwert, Margarete, Joas, Reinhard, Joas, Anke, Biot, Pierre, Aerts, Dominique, Casteleyn, Ludwine, Dumez, Birgit, Castaño, Argelia, Esteban, Marta, Angerer, Jürgen, Koch, Holger M, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Knudsen, Lisbeth E., Horvat, Milena, Bloemen, Louis, Katsonouri, Andromachi, Hadjipanayis, Adamos, Cerna, Milena, Krsková, Andrea, Jensen, Janne Fangel, Nielsen, Jeanette K S, Rudnai, Peter, Közepésy, Szilvia, Gutleb, Arno C, Fischer, Marc E, Ligocka, Danuta, Kamińska, Joanna, Reis, M Fátima, Namorado, Sónia, Lupsa, Ioana-Rodica, Gurzau, Anca E, Halzlová, Katarína, Mazej, Darja, Tratnik, Janja Snoj, Rivas, Teresa C, Gómez, Silvia, Berglund, Marika, Larsson, Kristin, Lehmann, Andrea, Crettaz, Pierre, Dewolf, Marie-Christine, Burns, Damien, Kellegher, Anne, Kolossa-Gehring, Marike, Fiddicke, Ulrike, Becker, Kerstin, Schwedler, Gerda, Seiwert, Margarete, Joas, Reinhard, Joas, Anke, Biot, Pierre, Aerts, Dominique, Casteleyn, Ludwine, Dumez, Birgit, Castaño, Argelia, Esteban, Marta, Angerer, Jürgen, Koch, Holger M, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Knudsen, Lisbeth E., Horvat, Milena, Bloemen, Louis, Katsonouri, Andromachi, Hadjipanayis, Adamos, Cerna, Milena, Krsková, Andrea, Jensen, Janne Fangel, Nielsen, Jeanette K S, Rudnai, Peter, Közepésy, Szilvia, Gutleb, Arno C, Fischer, Marc E, Ligocka, Danuta, Kamińska, Joanna, Reis, M Fátima, Namorado, Sónia, Lupsa, Ioana-Rodica, Gurzau, Anca E, Halzlová, Katarína, Mazej, Darja, Tratnik, Janja Snoj, Rivas, Teresa C, Gómez, Silvia, Berglund, Marika, Larsson, Kristin, Lehmann, Andrea, Crettaz, Pierre, Dewolf, Marie-Christine, Burns, Damien, Kellegher, Anne, and Kolossa-Gehring, Marike

Abstract

Within the European Environment and Health Action Plan an initiative to establish a coherent human biomonitoring approach in Europe was started. The project COPHES (COnsortium to Perform Human biomonitoring on a European Scale ) developed recommendations for a harmonized conduct of a human biomonitoring (HBM) survey which came into action as the pilot study DEMOCOPHES (DEMOnstration of a study to COordinate and Perform Human biomonitoring on a European Scale). Seventeen European countries conducted a survey with harmonized instruments for, inter alia, recruitment, fieldwork and sampling, in autumn/winter 2011/2012. Based on the countries' experiences of conducting the pilot study, following lessons learnt were compiled: the harmonized fieldwork instruments (basic questionnaire, urine and hair sampling) turned out to be very valuable for future HBM surveys on the European scale. A school approach was favoured by most of the countries to recruit school-aged children according to the established guidelines and country specific experiences. To avoid a low participation rate, intensive communication with the involved institutions and possible participants proved to be necessary. The communication material should also include information on exclusion criteria and offered incentives. Telephone contact to the participants the day before fieldwork during the survey can prevent the forgetting of appointments and first morning urine samples. To achieve comparable results on the European scale, training of interviewers in all issues of recruitment, fieldwork and sampling through information material and training sessions is crucial. A survey involving many European countries needs time for preparation and conduct. Materials for quality control prepared for all steps of recruitment, fieldwork and sampling proved to be important to warrant reliable results.

Published
2015

17. Urinary BPA measurements in children and mothers from six European member states:Overall results and determinants of exposure

Author

Covaci, Adrian, Hond, Elly Den, Geens, Tinne, Govarts, Eva, Koppen, Gudrun, Frederiksen, Hanne Winther, Knudsen, Lisbeth E., Mørck, Thit A, Gutleb, Arno C, Guignard, Cedric, Cocco, Emanuelle, Horvat, Milena, Heath, Ester, Kosjek, Tina, Mazej, Darja, Tratnik, Janja Snoj, Castaño, Argelia, Esteban, Marta, Cutanda, Francisco, Ramos, Juan José, Berglund, Marika, Larsson, Kristin, Jönsson, Bo A G, Biot, Pierre, Casteleyn, Ludwine, Joas, Reinhard, Joas, Anke, Bloemen, Louis, Sepai, Ovnair, Exley, Karen, Schoeters, Greet, Angerer, Jürgen, Kolossa-Gehring, Marike, Fiddicke, Ulrike, Aerts, Dominique, Koch, Holger M, Covaci, Adrian, Hond, Elly Den, Geens, Tinne, Govarts, Eva, Koppen, Gudrun, Frederiksen, Hanne Winther, Knudsen, Lisbeth E., Mørck, Thit A, Gutleb, Arno C, Guignard, Cedric, Cocco, Emanuelle, Horvat, Milena, Heath, Ester, Kosjek, Tina, Mazej, Darja, Tratnik, Janja Snoj, Castaño, Argelia, Esteban, Marta, Cutanda, Francisco, Ramos, Juan José, Berglund, Marika, Larsson, Kristin, Jönsson, Bo A G, Biot, Pierre, Casteleyn, Ludwine, Joas, Reinhard, Joas, Anke, Bloemen, Louis, Sepai, Ovnair, Exley, Karen, Schoeters, Greet, Angerer, Jürgen, Kolossa-Gehring, Marike, Fiddicke, Ulrike, Aerts, Dominique, and Koch, Holger M

Abstract

For the first time in Europe, both European-wide and country-specific levels of urinary Bisphenol A (BPA) were obtained through a harmonized protocol for participant recruitment, sampling and quality controlled biomarker analysis in the frame of the twin projects COPHES and DEMOCOPHES. 674 child-mother pairs were recruited through schools or population registers from six European member states (Belgium, Denmark, Luxembourg, Slovenia, Spain and Sweden). Children (5-12y) and mothers donated a urine sample. Information on socio-demographic characteristics, life style, dietary habits, and educational level of the parents was provided by mothers. After exclusion of urine samples with creatinine values below 300mg/L or above 3000mg/L, 653 children and 639 mothers remained for which BPA was measured. The geometric mean (with 95% confidence intervals) and 90th percentile were calculated for BPA separately in children and in mothers and were named "European reference values". After adjustment for confounders (age and creatinine), average exposure values in each country were compared with the mean of the "European reference values" by means of a weighted analysis of variance. Overall geometric means of all countries (95% CI) adjusted for urinary creatinine, age and gender were 2.04 (1.87-2.24) µg/L and 1.88 (1.71-2.07) µg/L for children (n=653) and mothers (n=639), respectively. Multiple regression analysis was used to identify significant environmental, geographical, personal or life style related determinants. Consumption of canned food and social class (represented by the highest educational level of the family) were the most important predictors for the urinary levels of BPA in mothers and children. The individual BPA levels in children were significantly correlated with the levels in their mothers (r=0.265, p<0.001), which may suggest a possible common environmental/dietary factor that influences the biomarker level in each pair. Exposure of the general European po

Published
2015

18. Mercury analysis in hair:Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project

Author

Esteban, Marta, Schindler, Birgit K, Jiménez-Guerrero, José A, Koch, Holger M, Angerer, Jürgen, Rivas, Teresa C, Rosado, Montserrat, Gómez, Silvia, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Becker, Kerstin, Bloemen, Louis, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Horvat, Milena, Knudsen, Lisbeth E., Joas, Anke, Joas, Reinhard, Aerts, Dominique, Biot, Pierre, Borošová, Daniela, Davidson, Fred, Dumitrascu, Irina, Fisher, Marc E, Grander, Margaretha, Janasik, Beata, Jones, Kate, Kašparová, Lucie, Larssen, Thorjørn, Naray, Miklos, Nielsen, Flemming, Hohenblum, Philipp, Pinto, Rui, Pirard, Catherine, Plateel, Gregory, Tratnik, Janja, Wittsiepe, Jürgen, Castaño, Argelia, Equas Reference Laboratories, Esteban, Marta, Schindler, Birgit K, Jiménez-Guerrero, José A, Koch, Holger M, Angerer, Jürgen, Rivas, Teresa C, Rosado, Montserrat, Gómez, Silvia, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Becker, Kerstin, Bloemen, Louis, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Horvat, Milena, Knudsen, Lisbeth E., Joas, Anke, Joas, Reinhard, Aerts, Dominique, Biot, Pierre, Borošová, Daniela, Davidson, Fred, Dumitrascu, Irina, Fisher, Marc E, Grander, Margaretha, Janasik, Beata, Jones, Kate, Kašparová, Lucie, Larssen, Thorjørn, Naray, Miklos, Nielsen, Flemming, Hohenblum, Philipp, Pinto, Rui, Pirard, Catherine, Plateel, Gregory, Tratnik, Janja, Wittsiepe, Jürgen, Castaño, Argelia, and Equas Reference Laboratories

Abstract

Human biomonitoring (HBM) is an effective tool for assessing actual exposure to chemicals that takes into account all routes of intake. Although hair analysis is considered to be an optimal biomarker for assessing mercury exposure, the lack of harmonization as regards sampling and analytical procedures has often limited the comparison of data at national and international level. The European-funded projects COPHES and DEMOCOPHES developed and tested a harmonized European approach to Human Biomonitoring in response to the European Environment and Health Action Plan. Herein we describe the quality assurance program (QAP) for assessing mercury levels in hair samples from more than 1800 mother-child pairs recruited in 17 European countries. To ensure the comparability of the results, standard operating procedures (SOPs) for sampling and for mercury analysis were drafted and distributed to participating laboratories. Training sessions were organized for field workers and four external quality-assessment exercises (ICI/EQUAS), followed by the corresponding web conferences, were organized between March 2011 and February 2012. ICI/EQUAS used native hair samples at two mercury concentration ranges (0.20-0.71 and 0.80-1.63) per exercise. The results revealed relative standard deviations of 7.87-13.55% and 4.04-11.31% for the low and high mercury concentration ranges, respectively. A total of 16 out of 18 participating laboratories the QAP requirements and were allowed to analyze samples from the DEMOCOPHES pilot study. Web conferences after each ICI/EQUAS revealed this to be a new and effective tool for improving analytical performance and increasing capacity building. The procedure developed and tested in COPHES/DEMOCOPHES would be optimal for application on a global scale as regards implementation of the Minamata Convention on Mercury.

Published
2015

19. Exposure determinants of cadmium in European mothers and their children

Author

Berglund, Marika, Larsson, Kristin, Grandér, Margaretha, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Schwedler, Gerda, Castaño, Argelia, Esteban, Marta, Angerer, Jürgen, Koch, Holger M, Schindler, Birgit K, Schoeters, Greet, Smolders, Roel, Exley, Karen, Sepai, Ovnair, Blumen, Luies, Horvat, Milena, Knudsen, Lisbeth E., Mørck, Thit A, Joas, Anke, Joas, Reinhard, Biot, Pierre, Aerts, Dominique, De Cremer, Koen, Van Overmeire, Ilse, Katsonouri, Andromachi, Hadjipanayis, Adamos, Cerna, Milena, Krskova, Andrea, Nielsen, Jeanette K S, Jensen, Janne Fangel, Rudnai, Peter, Kozepesy, Szilvia, Griffin, Chris, Nesbitt, Ian, Gutleb, Arno C, Fischer, Marc E, Ligocka, Danuta, Jakubowski, Marek, Reis, M Fátima, Namorado, Sónia, Lupsa, Ioana-Rodica, Gurzau, Anca E, Halzlova, Katarina, Jajcaj, Michal, Mazej, Darja, Tratnik, Janja Snoj, Lopez, Ana, Cañas, Ana, Lehmann, Andrea, Crettaz, Pierre, Hond, Elly Den, Govarts, Eva, Berglund, Marika, Larsson, Kristin, Grandér, Margaretha, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Schwedler, Gerda, Castaño, Argelia, Esteban, Marta, Angerer, Jürgen, Koch, Holger M, Schindler, Birgit K, Schoeters, Greet, Smolders, Roel, Exley, Karen, Sepai, Ovnair, Blumen, Luies, Horvat, Milena, Knudsen, Lisbeth E., Mørck, Thit A, Joas, Anke, Joas, Reinhard, Biot, Pierre, Aerts, Dominique, De Cremer, Koen, Van Overmeire, Ilse, Katsonouri, Andromachi, Hadjipanayis, Adamos, Cerna, Milena, Krskova, Andrea, Nielsen, Jeanette K S, Jensen, Janne Fangel, Rudnai, Peter, Kozepesy, Szilvia, Griffin, Chris, Nesbitt, Ian, Gutleb, Arno C, Fischer, Marc E, Ligocka, Danuta, Jakubowski, Marek, Reis, M Fátima, Namorado, Sónia, Lupsa, Ioana-Rodica, Gurzau, Anca E, Halzlova, Katarina, Jajcaj, Michal, Mazej, Darja, Tratnik, Janja Snoj, Lopez, Ana, Cañas, Ana, Lehmann, Andrea, Crettaz, Pierre, Hond, Elly Den, and Govarts, Eva

Abstract

The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother-child couples from 16 European countries. The aim of the study was to evaluate the overall Cd exposure and significant determinants of Cd exposure. A study population of 1632 women (24-52 years of age), and 1689 children (5-12 years of age), from 32 rural and urban areas, was examined within a core period of 6 months in 2011-2012. Women were stratified as smokers and non-smokers. As expected, smoking mothers had higher geometric mean (gm) urinary cadmium (UCd; 0.24µg/g crea; n=360) than non-smoking mothers (gm 0.18µg/g crea; n=1272; p<0.0001), and children had lower UCd (gm 0.065µg/g crea; n=1689) than their mothers at the country level. Non-smoking women exposed to environmental tobacco smoke (ETS) at home had 14% (95% CI 1-28%) higher UCd than those who were not exposed to ETS at home (p=0.04). No influence of ETS at home or other places on UCd levels was detected in children. Smoking women with primary education as the highest educational level of the household had 48% (95% CI 18-86%) higher UCd than those with tertiary education (p=0.0008). The same observation was seen in non-smoking women and in children; however they were not statistically significant. In children, living in a rural area was associated with 7% (95% CI 1-13%) higher UCd (p=0.03) compared to living in an urban area. Children, 9-12 years had 7% (95% CI 1-13%) higher UCd (p=0.04) than children 5-8 years. About 1% of the mothers, and 0.06% of the children, exceeded the tolerable weekly intake (TWI) appoin

Published
2015

20. Policy recommendations and cost implications for a more sustainable framework for European human biomonitoring surveys

Author

Joas, Anke, primary, Knudsen, Lisbeth E., additional, Kolossa-Gehring, Marike, additional, Sepai, Ovnair, additional, Casteleyn, Ludwine, additional, Schoeters, Greet, additional, Angerer, Jürgen, additional, Castaño, Argelia, additional, Aerts, Dominique, additional, Biot, Pierre, additional, Horvat, Milena, additional, Bloemen, Louis, additional, Reis, M. Fátima, additional, Lupsa, Ioana-Rodica, additional, Katsonouri, Andromachi, additional, Cerna, Milena, additional, Berglund, Marika, additional, Crettaz, Pierre, additional, Rudnai, Peter, additional, Halzlova, Katarina, additional, Mulcahy, Maurice, additional, Gutleb, Arno C., additional, Fischer, Marc E., additional, Becher, Georg, additional, Fréry, Nadine, additional, Jensen, Genon, additional, Van Vliet, Lisette, additional, Koch, Holger M., additional, Hond, Elly Den, additional, Fiddicke, Ulrike, additional, Esteban, Marta, additional, Exley, Karen, additional, Schwedler, Gerda, additional, Seiwert, Margarete, additional, Ligocka, Danuta, additional, Hohenblum, Philipp, additional, Kyrtopoulos, Soterios, additional, Botsivali, Maria, additional, DeFelip, Elena, additional, Guillou, Claude, additional, Reniero, Fabiano, additional, Grazuleviciene, Regina, additional, Veidebaum, Toomas, additional, Mørck, Thit A., additional, Nielsen, Jeanette K.S., additional, Jensen, Janne F., additional, Rivas, Teresa C., additional, Sanchez, Jinny, additional, Koppen, Gudrun, additional, Smolders, Roel, additional, Kozepesy, Szilvia, additional, Hadjipanayis, Adamos, additional, Krskova, Andrea, additional, Mannion, Rory, additional, Jakubowski, Marek, additional, Fucic, J. Aleksandra, additional, Pereira-Miguel, Jose, additional, Gurzau, Anca E., additional, Jajcaj, Michal, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Lehmann, Andrea, additional, Larsson, Kristin, additional, Dumez, Birgit, additional, and Joas, Reinhard, additional

Published
2015
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21. Fish consumption patterns and hair mercury levels in children and their mothers in 17 EU countries

Author

Castaño, Argelia, primary, Cutanda, Francisco, additional, Esteban, Marta, additional, Pärt, Peter, additional, Navarro, Carmen, additional, Gómez, Silvia, additional, Rosado, Montserrat, additional, López, Ana, additional, López, Estrella, additional, Exley, Karen, additional, Schindler, Birgit K., additional, Govarts, Eva, additional, Casteleyn, Ludwine, additional, Kolossa-Gehring, Marike, additional, Fiddicke, Ulrike, additional, Koch, Holger, additional, Angerer, Jürgen, additional, Hond, Elly Den, additional, Schoeters, Greet, additional, Sepai, Ovnair, additional, Horvat, Milena, additional, Knudsen, Lisbeth E., additional, Aerts, Dominique, additional, Joas, Anke, additional, Biot, Pierre, additional, Joas, Reinhard, additional, Jiménez-Guerrero, José A., additional, Diaz, Gema, additional, Pirard, Catherine, additional, Katsonouri, Andromachi, additional, Cerna, Milena, additional, Gutleb, Arno C., additional, Ligocka, Danuta, additional, Reis, Fátima M, additional, Berglund, Marika, additional, Lupsa, Ioana-Rodica, additional, Halzlová, Katarína, additional, Charlier, Corinne, additional, Cullen, Elizabeth, additional, Hadjipanayis, Adamos, additional, Krsková, Andrea, additional, Jensen, Janne F, additional, Nielsen, Jeanette K, additional, Schwedler, Gerda, additional, Wilhelm, Michael, additional, Rudnai, Peter, additional, Középesy, Szilvia, additional, Davidson, Fred, additional, Fischer, Mark E., additional, Janasik, Beata, additional, Namorado, Sónia, additional, Gurzau, Anca E., additional, Jajcaj, Michal, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Larsson, Kristin, additional, Lehmann, Andrea, additional, Crettaz, Pierre, additional, Lavranos, Giagkos, additional, and Posada, Manuel, additional

Published
2015
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22. Lessons learnt on recruitment and fieldwork from a pilot European human biomonitoring survey

Author

Fiddicke, Ulrike, primary, Becker, Kerstin, additional, Schwedler, Gerda, additional, Seiwert, Margarete, additional, Joas, Reinhard, additional, Joas, Anke, additional, Biot, Pierre, additional, Aerts, Dominique, additional, Casteleyn, Ludwine, additional, Dumez, Birgit, additional, Castaño, Argelia, additional, Esteban, Marta, additional, Angerer, Jürgen, additional, Koch, Holger M., additional, Schoeters, Greet, additional, Hond, Elly Den, additional, Sepai, Ovnair, additional, Exley, Karen, additional, Knudsen, Lisbeth E., additional, Horvat, Milena, additional, Bloemen, Louis, additional, Katsonouri, Andromachi, additional, Hadjipanayis, Adamos, additional, Cerna, Milena, additional, Krsková, Andrea, additional, Jensen, Janne Fangel, additional, Nielsen, Jeanette K.S., additional, Rudnai, Peter, additional, Közepésy, Szilvia, additional, Gutleb, Arno C., additional, Fischer, Marc E., additional, Ligocka, Danuta, additional, Kamińska, Joanna, additional, Reis, M. Fátima, additional, Namorado, Sónia, additional, Lupsa, Ioana-Rodica, additional, Gurzau, Anca E., additional, Halzlová, Katarína, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Rivas, Teresa C., additional, Gómez, Silvia, additional, Berglund, Marika, additional, Larsson, Kristin, additional, Lehmann, Andrea, additional, Crettaz, Pierre, additional, Dewolf, Marie-Christine, additional, Burns, Damien, additional, Kellegher, Anne, additional, and Kolossa-Gehring, Marike, additional

Published
2015
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23. Mercury analysis in hair: Comparability and quality assessment within the transnational COPHES/DEMOCOPHES project

Author

Esteban, Marta, primary, Schindler, Birgit Karin, additional, Jiménez, José Antonio, additional, Koch, Holger Martin, additional, Angerer, Jürgen, additional, Rosado, Montserrat, additional, Gómez, Silvia, additional, Casteleyn, Ludwine, additional, Kolossa-Gehring, Marike, additional, Becker, Kerstin, additional, Bloemen, Louis, additional, Schoeters, Greet, additional, Hond, Elly Den, additional, Sepai, Ovnair, additional, Exley, Karen, additional, Horvat, Milena, additional, Knudsen, Lisbeth E., additional, Joas, Anke, additional, Joas, Reinhard, additional, Aerts, Dominique, additional, Biot, Pierre, additional, Borošová, Daniela, additional, Davidson, Fred, additional, Dumitrascu, Irina, additional, Fischer, Marc E., additional, Grander, Margaretha, additional, Janasik, Beata, additional, Jones, Kate, additional, Kašparová, Lucie, additional, Larssen, Thorjørn, additional, Naray, Miklos, additional, Nielsen, Flemming, additional, Hohenblum, Philipp, additional, Pinto, Rui, additional, Pirard, Catherine, additional, Plateel, Gregory, additional, Tratnik, Janja Snoj, additional, Wittsiepe, Jürgen, additional, and Castaño, Argelia, additional

Published
2015
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24. Exposure determinants of cadmium in European mothers and their children

Author

Berglund, Marika, primary, Larsson, Kristin, additional, Grandér, Margaretha, additional, Casteleyn, Ludwine, additional, Kolossa-Gehring, Marike, additional, Schwedler, Gerda, additional, Castaño, Argelia, additional, Esteban, Marta, additional, Angerer, Jürgen, additional, Koch, Holger M., additional, Schindler, Birgit K., additional, Schoeters, Greet, additional, Smolders, Roel, additional, Exley, Karen, additional, Sepai, Ovnair, additional, Blumen, Luies, additional, Horvat, Milena, additional, Knudsen, Lisbeth E., additional, Mørck, Thit A., additional, Joas, Anke, additional, Joas, Reinhard, additional, Biot, Pierre, additional, Aerts, Dominique, additional, De Cremer, Koen, additional, Van Overmeire, Ilse, additional, Katsonouri, Andromachi, additional, Hadjipanayis, Adamos, additional, Cerna, Milena, additional, Krskova, Andrea, additional, Nielsen, Jeanette K.S., additional, Jensen, Janne Fangel, additional, Rudnai, Peter, additional, Kozepesy, Szilvia, additional, Griffin, Chris, additional, Nesbitt, Ian, additional, Gutleb, Arno C., additional, Fischer, Marc E., additional, Ligocka, Danuta, additional, Jakubowski, Marek, additional, Reis, M. Fátima, additional, Namorado, Sónia, additional, Lupsa, Ioana-Rodica, additional, Gurzau, Anca E., additional, Halzlova, Katarina, additional, Jajcaj, Michal, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Lopez, Ana, additional, Cañas, Ana, additional, Lehmann, Andrea, additional, Crettaz, Pierre, additional, Hond, Elly Den, additional, and Govarts, Eva, additional

Published
2015
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25. Urinary BPA measurements in children and mothers from six European member states: Overall results and determinants of exposure

Author

Covaci, Adrian, primary, Hond, Elly Den, additional, Geens, Tinne, additional, Govarts, Eva, additional, Koppen, Gudrun, additional, Frederiksen, Hanne, additional, Knudsen, Lisbeth E., additional, Mørck, Thit A., additional, Gutleb, Arno C., additional, Guignard, Cedric, additional, Cocco, Emanuelle, additional, Horvat, Milena, additional, Heath, Ester, additional, Kosjek, Tina, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Castaño, Argelia, additional, Esteban, Marta, additional, Cutanda, Francisco, additional, Ramos, Juan José, additional, Berglund, Marika, additional, Larsson, Kristin, additional, Jönsson, Bo A.G., additional, Biot, Pierre, additional, Casteleyn, Ludwine, additional, Joas, Reinhard, additional, Joas, Anke, additional, Bloemen, Louis, additional, Sepai, Ovnair, additional, Exley, Karen, additional, Schoeters, Greet, additional, Angerer, Jürgen, additional, Kolossa-Gehring, Marike, additional, Fiddicke, Ulrike, additional, Aerts, Dominique, additional, and Koch, Holger M., additional

Published
2015
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26. Case study: Possible differences in phthalates exposure among the Czech, Hungarian, and Slovak populations identified based on the DEMOCOPHES pilot study results

Author

Černá, Milena, primary, Malý, Marek, additional, Rudnai, Peter, additional, Középesy, Szilvia, additional, Náray, Miklós, additional, Halzlová, Katarina, additional, Jajcaj, Michal, additional, Grafnetterová, Anna, additional, Krsková, Andrea, additional, Antošová, Danuše, additional, Forysová, Kateřina, additional, Hond, Elly Den, additional, Schoeters, Greet, additional, Joas, Reinhard, additional, Casteleyn, Ludwine, additional, Joas, Anke, additional, Biot, Pierre, additional, Aerts, Dominique, additional, Angerer, Jürgen, additional, Bloemen, Louis, additional, Castaño, Argelia, additional, Esteban, Marta, additional, Koch, Holger M., additional, Kolossa-Gehring, Marike, additional, Gutleb, Arno C., additional, Pavloušková, Jana, additional, and Vrbík, Karel, additional

Published
2015
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28. Neurobehavioral function and low-level metal exposure in adolescents

Author

Kicinski, Michal, primary, Vrijens, Jan, additional, Vermier, Griet, additional, Hond, Elly Den, additional, Schoeters, Greet, additional, Nelen, Vera, additional, Bruckers, Liesbeth, additional, Sioen, Isabelle, additional, Baeyens, Willy, additional, Van Larebeke, Nicolas, additional, Viaene, Mineke K., additional, and Nawrot, Tim S., additional

Published
2015
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29. State of the Environment report 2010, Background document, Theme: Distribution of heavy metals

Author

Peeters, Bob, Bierkens, Johan G E A, Provoost, Jeroen, Hond, Elly Den, Volsem, Sofie Van, Adriaenssens, Elke, Roekens, Edward, Bossuyt, Myriam, Theuns, Ilse, Cooman, Ward De, Eppinger, Ralf, Frohnhoffs, Alistair, D’hont, Didier, Geeraerts, Caroline, Belpaire, Claude, Cardon, Marijke, Ceenaeme, Johan, Naeyer, Filip De, Gommeren, Els, and Dyck, Eddy Van

Published
2010
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30. Mercury exposure in Ireland:results of the DEMOCOPHES human biomonitoring study

Author

Cullen, Elizabeth, Evans, David S, Davidson, Fred, Burke, Padraig, Burns, Damien, Flanagan, Andrew, Griffin, Chris, Kellegher, Anne, Mannion, Rory, Mulcahy, Maurice, Ryan, Michael, Biot, Pierre, Casteleyn, Ludwine, Castaño, Argelia, Angerer, Jürgen, Koch, Holger M, Esteban, Marta, Schindler, Birgit K, Navarro, Carmen, Kolossa-Gehring, Marike, Fiddicke, Ulrike, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Bloemen, Louis, Knudsen, Lisbeth E., Joas, Reinhard, Joas, Anke, Aerts, Dominique, Cullen, Elizabeth, Evans, David S, Davidson, Fred, Burke, Padraig, Burns, Damien, Flanagan, Andrew, Griffin, Chris, Kellegher, Anne, Mannion, Rory, Mulcahy, Maurice, Ryan, Michael, Biot, Pierre, Casteleyn, Ludwine, Castaño, Argelia, Angerer, Jürgen, Koch, Holger M, Esteban, Marta, Schindler, Birgit K, Navarro, Carmen, Kolossa-Gehring, Marike, Fiddicke, Ulrike, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Bloemen, Louis, Knudsen, Lisbeth E., Joas, Reinhard, Joas, Anke, and Aerts, Dominique

Abstract

BACKGROUND: Monitoring of human exposure to mercury is important due to its adverse health effects. This study aimed to determine the extent of mercury exposure among mothers and their children in Ireland, and to identify factors associated with elevated levels. It formed part of the Demonstration of a study to Coordinate and Perform Human Biomonitoring on a European Scale (DEMOCOPHES) pilot biomonitoring study.METHODS: Hair mercury concentrations were determined from a convenience sample of 120 mother/child pairs. Mothers also completed a questionnaire. Rigorous quality assurance within DEMOCOPHES guaranteed the accuracy and international comparability of results.RESULTS: Mercury was detected in 79.2% of the samples from mothers, and 62.5% of children's samples. Arithmetic mean levels in mothers (0.262 µg/g hair) and children (0.149 µg /g hair) did not exceed the US EPA guidance value. Levels were significantly higher for those with higher education, and those who consumed more fish.CONCLUSIONS: The study demonstrates the benefit of human biomonitoring for assessing and comparing internal exposure levels, both on a population and an individual basis. It enables the potential harmful impact of mercury to be minimised in those highly exposed, and can therefore significantly contribute to population health.

Published
2014

31. The European COPHES/DEMOCOPHES project:Towards transnational comparability and reliability of human biomonitoring results

Author

Schindler, Birgit Karin, Esteban, Marta, Koch, Holger Martin, Castano, Argelia, Koslitz, Stephan, Cañas, Ana, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Schwedler, Gerda, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Bloemen, Louis, Horvat, Milena, Knudsen, Lisbeth E, Joas, Anke, Joas, Reinhard, Biot, Pierre, Aerts, Dominique, Lopez, Ana, Huetos, Olga, Katsonouri, Andromachi, Maurer-Chronakis, Katja, Kasparova, Lucie, Vrbík, Karel, Rudnai, Peter, Naray, Miklos, Guignard, Cedric, Fischer, Marc E, Ligocka, Danuta, Janasik, Beata, Reis, M Fátima, Namorado, Sónia, Pop, Cristian, Dumitrascu, Irina, Halzlova, Katarina, Fabianova, Eleonora, Mazej, Darja, Tratnik, Janja Snoj, Berglund, Marika, Jönsson, Bo, Lehmann, Andrea, Crettaz, Pierre, Frederiksen, Hanne, Nielsen, Flemming, McGrath, Helena, Nesbitt, Ian, De Cremer, Koen, Vanermen, Guido, Koppen, Gudrun, Wilhelm, Michael, Becker, Kerstin, Angerer, Jürgen, Schindler, Birgit Karin, Esteban, Marta, Koch, Holger Martin, Castano, Argelia, Koslitz, Stephan, Cañas, Ana, Casteleyn, Ludwine, Kolossa-Gehring, Marike, Schwedler, Gerda, Schoeters, Greet, Hond, Elly Den, Sepai, Ovnair, Exley, Karen, Bloemen, Louis, Horvat, Milena, Knudsen, Lisbeth E, Joas, Anke, Joas, Reinhard, Biot, Pierre, Aerts, Dominique, Lopez, Ana, Huetos, Olga, Katsonouri, Andromachi, Maurer-Chronakis, Katja, Kasparova, Lucie, Vrbík, Karel, Rudnai, Peter, Naray, Miklos, Guignard, Cedric, Fischer, Marc E, Ligocka, Danuta, Janasik, Beata, Reis, M Fátima, Namorado, Sónia, Pop, Cristian, Dumitrascu, Irina, Halzlova, Katarina, Fabianova, Eleonora, Mazej, Darja, Tratnik, Janja Snoj, Berglund, Marika, Jönsson, Bo, Lehmann, Andrea, Crettaz, Pierre, Frederiksen, Hanne, Nielsen, Flemming, McGrath, Helena, Nesbitt, Ian, De Cremer, Koen, Vanermen, Guido, Koppen, Gudrun, Wilhelm, Michael, Becker, Kerstin, and Angerer, Jürgen

Abstract

COPHES/DEMOCOPHES has its origins in the European Environment and Health Action Plan of 2004 to "develop a coherent approach on human biomonitoring (HBM) in Europe". Within this twin-project it was targeted to collect specimens from 120 mother-child-pairs in each of the 17 participating European countries. These specimens were investigated for six biomarkers (mercury in hair; creatinine, cotinine, cadmium, phthalate metabolites and bisphenol A in urine). The results for mercury in hair are described in a separate paper. Each participating member state was requested to contract laboratories, for capacity building reasons ideally within its borders, carrying out the chemical analyses. To ensure comparability of analytical data a Quality Assurance Unit (QAU) was established which provided the participating laboratories with standard operating procedures (SOP) and with control material. This material was specially prepared from native, non-spiked, pooled urine samples and was tested for homogeneity and stability. Four external quality assessment exercises were carried out. Highly esteemed laboratories from all over the world served as reference laboratories. Web conferences after each external quality assessment exercise functioned as a new and effective tool to improve analytical performance, to build capacity and to educate less experienced laboratories. Of the 38 laboratories participating in the quality assurance exercises 14 laboratories qualified for cadmium, 14 for creatinine, 9 for cotinine, 7 for phthalate metabolites and 5 for bisphenol A in urine. In the last of the four external quality assessment exercises the laboratories that qualified for DEMOCOPHES performed the determinations in urine with relative standard deviations (low/high concentration) of 18.0/2.1% for cotinine, 14.8/5.1% for cadmium, 4.7/3.4% for creatinine. Relative standard deviations for the newly emerging biomarkers were higher, with values between 13.5 and 20.5% for bisphenol A and betw

Published
2014

32. Human biomonitoring in Flanders: some aspects related to study design, future, communication and ethics

Author

Hond, Elly Den, Chovanova, Hana, Dumez, Birgit, Keune, Hans, Schoeters, Greet, Teughels, Caroline, and Van Campenhout, Karen

Subjects
Philosophy, Surveillance, Sociology, Biomonitoring, Flanders, Biomarkers
Abstract

Flanders is one of the few places in Europe with a legal basis to perform human biomonitoring (HBM). The HBM study is commissioned, steered and funded by the Flemish government and is carried out by the Center of Expertise for Environment and Health. This research consortium includes scientists from all Flemish universities and two Flemish research institutes. The main purpose of the Flemish HBM program is to establish a surveillance network to make it possible to measure environmental pollution in the population and to investigate the relation between exposure and early health effects. In the first campaign (2001-2006) the question was whether living in different areas in Flanders resulted in a different exposure to environmental pollution. To make the translation of the HBM results into policy measures, the phased action plan was developed. The second cycle of the Flemish HBM programme (2007-2011) is built on two pillars. First, reference values for the Flemish population will be obtained in a representative population sample for a broad series of pollutants. Second, targeted HBM will be performed in specific groups with a concern for environmental pollution pressure, the so-called hot spots. In both parts of the project, emphasis is placed on open and transparent communication and relevant interaction between scientists, policy makers, authorities, stakeholders and the public through a participative process. HBM requires the collaboration of volunteers to donate blood, urine or other bodily tissues, and thus raises inevitable ethical questions. Some aspects showing that communication is at the heart of ethics are presented, as well as some difficulties from within the practices that arise in transnational research context. The work on ethics was partly supported by ECNIS NoE (Environmental Cancer Risk, Nutrition and Individual Susceptibility) (Contract No 513943), and NewGeneris IP (Contract No 016320-2), operating within the European Union 6th Framework Programme, Priority 5: "Food Quality and Safety"

Published
2009

33. State of the Environment report 2007, Background document, Theme: Distribution of heavy metals

Author

Bierkens, Johan G E A, Provoost, Jeroen, Hond, Elly Den, Volsem, Sofie Van, Desmedt, Marjory, Roekens, Edward, Theuns, Ilse, Cooman, Ward De, Claeys, Natacha, Dumolin, Jasmine, Eppinger, Ralf, Frohnhoffs, Alistair, D’hont, Didier, Goemans, Geert, Belpaire, Claude, Lettens, Suzanna, Vos, Bruno De, Bulck, Sofie Van Den, Ceenaeme, Johan, Dedecker, Dirk, Naeyer, Filip De, Dries, Victor, Gommeren, Els, Dijck, Wendy Van, Dyck, Eddy Van, D’Havé, Helga, Coen, Wim De, and Peeters, Bob

Published
2007
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34. Determinants of bisphenol A and phthalate metabolites in urine of Flemish adolescents

Author

Geens, Tinne, primary, Bruckers, Liesbeth, additional, Covaci, Adrian, additional, Schoeters, Greet, additional, Fierens, Tine, additional, Sioen, Isabelle, additional, Vanermen, Guido, additional, Baeyens, Willy, additional, Morrens, Bert, additional, Loots, Ilse, additional, Nelen, Vera, additional, de Bellevaux, Benoit Nemery, additional, Larebeke, Nik Van, additional, and Hond, Elly Den, additional

Published
2014
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35. The European COPHES/DEMOCOPHES project: Towards transnational comparability and reliability of human biomonitoring results

Author

Schindler, Birgit Karin, primary, Esteban, Marta, additional, Koch, Holger Martin, additional, Castano, Argelia, additional, Koslitz, Stephan, additional, Cañas, Ana, additional, Casteleyn, Ludwine, additional, Kolossa-Gehring, Marike, additional, Schwedler, Gerda, additional, Schoeters, Greet, additional, Hond, Elly Den, additional, Sepai, Ovnair, additional, Exley, Karen, additional, Bloemen, Louis, additional, Horvat, Milena, additional, Knudsen, Lisbeth E., additional, Joas, Anke, additional, Joas, Reinhard, additional, Biot, Pierre, additional, Aerts, Dominique, additional, Lopez, Ana, additional, Huetos, Olga, additional, Katsonouri, Andromachi, additional, Maurer-Chronakis, Katja, additional, Kasparova, Lucie, additional, Vrbík, Karel, additional, Rudnai, Peter, additional, Naray, Miklos, additional, Guignard, Cedric, additional, Fischer, Marc E., additional, Ligocka, Danuta, additional, Janasik, Beata, additional, Reis, M. Fátima, additional, Namorado, Sónia, additional, Pop, Cristian, additional, Dumitrascu, Irina, additional, Halzlova, Katarina, additional, Fabianova, Eleonora, additional, Mazej, Darja, additional, Tratnik, Janja Snoj, additional, Berglund, Marika, additional, Jönsson, Bo, additional, Lehmann, Andrea, additional, Crettaz, Pierre, additional, Frederiksen, Hanne, additional, Nielsen, Flemming, additional, McGrath, Helena, additional, Nesbitt, Ian, additional, De Cremer, Koen, additional, Vanermen, Guido, additional, Koppen, Gudrun, additional, Wilhelm, Michael, additional, Becker, Kerstin, additional, and Angerer, Jürgen, additional

Published
2014
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36. Expression of the sFLT1 Gene in Cord Blood Cells Is Associated to Maternal Arsenic Exposure and Decreased Birth Weight

Author

Remy, Sylvie, primary, Govarts, Eva, additional, Bruckers, Liesbeth, additional, Paulussen, Melissa, additional, Wens, Britt, additional, Hond, Elly Den, additional, Nelen, Vera, additional, Baeyens, Willy, additional, van Larebeke, Nicolas, additional, Loots, Ilse, additional, Sioen, Isabelle, additional, and Schoeters, Greet, additional

Published
2014
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37. A systematic approach for designing a HBM Pilot Study for Europe

Author

Becker, Kerstin, primary, Seiwert, Margarete, additional, Casteleyn, Ludwine, additional, Joas, Reinhard, additional, Joas, Anke, additional, Biot, Pierre, additional, Aerts, Dominique, additional, Castaño, Argelia, additional, Esteban, Marta, additional, Angerer, Jürgen, additional, Koch, Holger M., additional, Schoeters, Greet, additional, Hond, Elly Den, additional, Sepai, Ovnair, additional, Exley, Karen, additional, Knudsen, Lisbeth E., additional, Horvat, Milena, additional, Bloemen, Louis, additional, and Kolossa-Gehring, Marike, additional

Published
2014
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38. Health effects in the Flemish population in relation to low levels of mercury exposure: From organ to transcriptome level

Author

Croes, Kim, primary, De Coster, Sam, additional, De Galan, Sandra, additional, Morrens, Bert, additional, Loots, Ilse, additional, Van de Mieroop, Els, additional, Nelen, Vera, additional, Sioen, Isabelle, additional, Bruckers, Liesbeth, additional, Nawrot, Tim, additional, Colles, Ann, additional, Hond, Elly Den, additional, Schoeters, Greet, additional, van Larebeke, Nicolas, additional, Baeyens, Willy, additional, and Gao, Yue, additional

Published
2014
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41. Exposure to brominated flame retardants, perfluorinated compounds, phthalates and phenols in European birth cohorts: ENRIECO evaluation, first human biomonitoring results, and recommendations

Author

Casas, Maribel, primary, Chevrier, Cécile, additional, Hond, Elly Den, additional, Fernandez, Mariana F., additional, Pierik, Frank, additional, Philippat, Claire, additional, Slama, Rémy, additional, Toft, Gunnar, additional, Vandentorren, Stéphanie, additional, Wilhelm, Michael, additional, and Vrijheid, Martine, additional

Published
2013
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42. S-149

Author

Schoeters, Greet, primary, Hond, Elly Den, additional, Govarts, Eva, additional, Smolders, Roel, additional, Casteleyn, Ludwine, additional, Joas, Reinhard, additional, Joas, Anke, additional, Biot, Pierre, additional, Aerts, Dominique, additional, Kolossa-Gehring, Marike, additional, Castano, Argelia, additional, Angerer, Jurgen, additional, Sepai, Ovnair, additional, Knudsen, Lisbeth, additional, Horvat, Milena, additional, and Bloemen, Louis, additional

Published
2012
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44. Concept of the Flemish human biomonitoring programme

Author

Schoeters, Greet, primary, Hond, Elly Den, additional, Colles, Ann, additional, Loots, Ilse, additional, Morrens, Bert, additional, Keune, Hans, additional, Bruckers, Liesbeth, additional, Nawrot, Tim, additional, Sioen, Isabelle, additional, De Coster, Sam, additional, Van Larebeke, Nicolas, additional, Nelen, Vera, additional, Van de Mieroop, Els, additional, Vrijens, Jan, additional, Croes, Kim, additional, Goeyens, Karen, additional, and Baeyens, Willy, additional

Published
2012
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46. ADDITION OF MEASUREMENTS OF BISPHENOL A IN URINE TO THE STUDY PROTOCOL FOR A EUROPEAN HUMAN BIOMONITORING (HBM) PILOT STUDY

Author

Knudsen, Lisbeth E., primary, Mørck, Thit Aarøe, additional, Aerts, Dominique, additional, Biot, Pierre, additional, Joas, Reinhard, additional, Joas, Anke, additional, Casteleyn, Ludwine, additional, Becker, Kerstin, additional, Kolossa-Gehring, Marike, additional, Castano, Argelia, additional, Angerer, Juergen, additional, Schoeters, Greet, additional, Hond, Elly den, additional, Sepai, Ovnair, additional, Exley, Karen, additional, Heath, Ester, additional, Horvat, Milena, additional, and Bloemen, Louis, additional

Published
2011
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50. Dietary exposure to dioxin-like compounds in three age groups: Results from the Flemish environment and health study

Author

Bilau, Maaike, primary, Matthys, Christophe, additional, Baeyens, Willy, additional, Bruckers, Liesbeth, additional, Backer, Guy De, additional, Hond, Elly Den, additional, Keune, Hans, additional, Koppen, Gudrun, additional, Nelen, Vera, additional, Schoeters, Greet, additional, Van Larebeke, Nicolas, additional, Willems, Jan L., additional, and De Henauw, Stefaan, additional

Published
2008
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