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103 results on '"Hyde, Emily"'

4. Return of genetic research results in 21,532 individuals with autism

Author

Aarrestad, Alexandria, Abbeduto, Leonard, Aberbach, Gabriella, Aberle, Shelley, Adegbite, Adediwura, Adeniji, Debbie, Aguilar, Maria, Ahlers, Kaitlyn, Albright, Charles, Alessandri, Michael, Algaze, Zach, Alkazi, Jasem, Amador, Raquel, Amaral, David, Amon, Logan, Amundsen, Leonor, Andrus, Alicia, Anglo, Claudine, Annett, Robert, Arar, Adam, Arnold, Jonathan, Arriaga, Ivette, Arzate, Eduardo, Ashley, Raven, Aslamy, Leilemah, Baalman, Kelli, Baer, Melissa, Bahi, Ethan, Bailey, Joshua, Baldlock, Zachary, Banks, Grabrielle, Baraghoshi, Gabriele, Bardett, Nicole, Barrett, Mallory, Bartholomew, Yan, Bates, Heidi, Beard, Katie, Becerra, Juana, Beckwith, Malia, Beechan, Paige, Beeson, Landon, Beeson, Josh, Bell, Brandi, Belli, Monica, Bentley, Dawn, Berger, Natalie, Berman, Anna, Bernier, Raphael, Berry-Kravis, Elizabeth, Berwanger, Mary, Birdwell, Shelby, Blank, Elizabeth, Bond, Rebecca, Booker, Stephanie, Bordofsky, Aniela, Bower, Erin, Bowers, Lukas, Bradley, Catherine, Brayer, Heather, Brewster, Stephanie, Brown, Hallie, Brown, Alison, Brown, Melissa, Buck, Catherine, Buescher, Cate, Bullon, Kayleigh, Buraima, Joy, Butter, Eric, Caamano, Amalia, Cacciato, Nicole, CaI, Wenteng, Calderon, Norma, Callahan, Kristen, Camba, Alexies, Campo-Soria, Claudia, Caprara, Giuliana, Carbone, Paul, Carpenter, Laura, Carpenter, Sarah, Casseus, Myriam, Casten, Lucas, Catherine, Sullivan, Chappo, Ashley, Chavez, Kimberly, Cheathem-Johnson, Randi, Chen, Tia, Chintalapalli, Sharmista, Cho, Daniel, Choi, Y.B., Clark, Nia, Clark, Renee, Coffman, Marika, Coleman, Laura, Coleman, Kendra, Collins, Alister, Columbi, Costanza, Comitre, Joaquin, Constant, Stephanie, Contra, Arin, Conyers, Sarah, Cooper, Lindsey, Cooper, Cameron, Coppola, Leigh, Corlett, Allison, Corrales, Lady, Correa, Dahriana, Cottrell, Hannah, Coughlin, Michelle, Courchesne, Eric, Coury, Dan, Crocetti, Deana, Croson, Carrie, Crowell, Judith, Cubells, Joseph, Cunningham, Sean, Currin, Mary, Cutri, Michele, D'Ambrosi, Sophia, David, Giancarla, Davis, Ayana, Davis, Sabrina, Decius, Nickelle, Delaporte, Jennifer, DeMarco, Lindsey, Dennis, Brandy, Deronda, Alyssa, Dhawan, Esha, Dichter, Gabriel, Doan, Ryan, Dominick, Kelli, Ortega, Leonardo Dominquez, Doyle, Erin, Drayton, Andrea, DuBois, Megan, Dudley, Johnny, Duhon, Gabrielle, Duncan, Grabrielle, Duncan, Amie, Dunlevy, Megan, Dyer, Meaghan, Earl, Rachel, Edmonson, Catherine, Eldred, Sara, Elliott, Nelita, Emery, Brooke, Enright, Barbara, Erb, Sarah, Erickson, Craig, Esler, Amy, Estevez, Liza, Fanta, Anne, Fassler, Carrie, Fatemi, Ali, Fazal, Faris, Featherston, Marilyn, Ferguson, Jonathan, Fish, Angela, Fitzgerald, Kate, Flores, Kathleen, Fombonne, Eric, Foster, Margaret, Fowler, Tiffany, Fox, Emma, Fox, Emily, Francis, Sunday, Frayne, Margot, Froman, Sierra, Fuller, Laura, Galbraith, Virginia, Gallimore, Dakota, Gambrell, Ariana, Gazestani, Vahid, Geisheker, Madeleine R., Gerdts, Jennifer, Geschwind, Daniel, Ghaziuddin, Mohammad, Ghina, Haidar, Given, Erin, Goetz, Mykayla, Gong, Jared, Gonring, Kelsey, Gonzalez, Natalia, Gonzalez, Antonio, Goodwill, Ellie, Gordon, Rachel, Graham, Carter, Gray, Catherine, Grimes, Ellen, Griswold, Anthony, Gu, Pan, Guilfoyle, Janna, Gulsrud, Amanda, Gunderson, Jaclyn, Gunter, Chris, Gupta, Sanya, Gupta, Abha, Gutierrez, Anibal, Gwynette, Frampton, Haidar, Ghina, Hale, Melissa, Haley, Monica, Hall, Lauren K., Hamer, Kira, Hamilton, Piper, Hanna, Nathan, Hardan, Antonio, Harkins, Christina, Harrell, Eldric, Harris, Jill, Harris, Nina, Hayes, Caitlin, Hayse, Braden, Heckers, Teryn, Heerwagen, Kathryn, Hennelly, Daniela, Herbert, Lynette, Hermle, Luke, Hernandez, Briana, Herrera, Clara, Hess, Amy, Heyman, Michelle, Higgins, Lorrin, Phillips, Brittani Hilscher, Hirst, Kathy, Ho, Theodore, Hoffman, Emily, Hojlo, Margaret, Honaker, Makayla, Hong, Michael, Hooks, Gregory, Horner, Susannah, Horton, Danielle, Hounchell, Melanie, Howes, Dain, Huang-Storm, Lark, Hunter, Samantha, Hutter, Hanna, Hyde, Emily, Ibanez, Teresa, Ingram, Kelly, Istephanous, Dalia, Jacob, Suma, Jarratt, Andrea, Jelinek, Anna, Johnson, Mary, Jones, Mya, Jones, Garland, Jones, Mark, Jorgenson, Alissa, Judge, Jessyca, Kalb, Luther, Kalmus, Taylor, Kang, Sungeun, Kangas, Elizabeth, Kanne, Stephen, Kaplan, Hannah, Khan, Sara, Kim, Sophy, Kim, Annes, Kitaygordsky, Alex, Klaiman, Cheryl, Klever, Adam, Koene, Hope, Koomar, Tanner, Koza, Melinda, Kramer, Sydney, Krushena, Meghan, Kurtz-Nelson, Eva, Lamarche, Elena, Lampert, Erica, Lamy, Martine, Landa, Rebecca, Lebron-Cruz, Alexa, Lechniak, Holly, Lee, Soo, Leight, Bruce, Lerner, Matthew, Lesher, Laurie, Lewis, Courtney, Li, Hai, Li, Deana, Libove, Robin, Lillie, Natasha, Limon, Danica, Limpoco, Desi, Lin, Melody, Littlefield, Sandy, Lobisi, Brandon, Locarno, Laura, Long, Nancy, Long, Bailey, Long, Kennadie, Lopez, Marilyn, Lovering, Taylor, Lozano, Ivana, Lucio, Daniella, Luo, Addie, Luu, My-Linh, Lyon, Audrey, Ma, Julia, Madi, Natalie, Malloch, Lacy, Mankaryous, Reanna, Manning, Patricia, Mantey, Alvin, Marini, Richard, Marsden, Alexandra, Marwali, Clarissa, Marzano, Gabriela, Mason, Andrew, Mastel, Sarah, Mathai, Sheena, Matthews, Emily, Matusoff, Emma, Maxim, Clara, McCarthy, Caitlin, McClellen, Lynn, Mccoy, Nicole, McCullough, Kaylen, McDonald, Brooke, McGalliard, Julie, McIntyre, Anne-Marie, McKenna, Brooke, McKenzie, Alexander, McTaggart, Megan, Meinen, Hannah, Melnyk, Sophia, Miceli, Alexandra, Michaels, Sarah, Michaelson, Jacob, Milan, Estefania, Miller, Melissa, Milliken, Anna, Minton, Kyla, Mitchell, Terry, Gunn, Amanda Moffitt, Mohiuddin, Sarah, Money, Gina, Montezuma, Jessie, Mooney, Lindsey, Moore, Margo, Morales-Lara, Amy, Morgan, Kelly, Morotti, Hadley, Morrier, Michael, Munoz, Maria, Lavanderos, Ambar Munoz, Murali, Shwetha, Murillo, Karla, Murray, Kailey, Myhre, Erin, Neely, Jason, Neuhaus, Emily, Newman, Olivia, Nguyen, Richard, Nguyen, Victoria, Nichols, Evelyn, Nicholson, Amy, Niederhauser, Melanie, Norris, Megan, Norton, Shai, Nowell, Kerri, O’Brien, Kaela, O’Meara, Mitchell, O’Neil, Molly, O'Roak, Brian, Ocampo, Edith, Ochoa-Lubinoff, Cesar, Oft, Anna, Orobio, Jessica, Ortiz, Crissy, Ousley, Opal, Oyeyemi, Motunrayo, Pacheco, Lillian, Palacios, Valeria, Palmer, Samiza, Palmeri, Isabella, Pama, Katrina, Pandey, Juhi, Paolicelli, Anna Marie, Parker, Jaylaan, Patterson, Morgan, Pawlowski, Katherine, Pedapati, Ernest, Pepper, Michah, Perrin, Jeremy, Peura, Christine, Phillips, Diamond, Pierce, Karen, Piven, Joseph, Plate, Juhi, Polanco, Jose, Pott-Schmidt, Natalie, Pramparo, Tiziano, Pratt, Taleen, Prock, Lisa, White, Stormi Pulver, Qi, Hongjian, Qiu, Shanping, Queen, Eva, Questel, Marcia, Quinones, Ashley, Rambeck, Desiree, Randall, Shelley, Ranganathan, Vaikunt, Raymond, Laurie, Rayos, Madelyn, Real, Kelly, Rhea, Anna, Rice, Catherine, Richardson, Harper, Riffle, Stacy, Robertson, Tracy, Roby, Erin, Rocha, Ana, Roche, Casey, Rodriguez, Nicki, Rodriguez, Bianca, Roeder, Katherine, Rojas, Daniela, Rosewater, Jacob, Rosselott, Hilary, Runyan, Payton, Russo, Nicole, Rutter, Tara, Ruzzo, Elizabeth, Sahin, Mustafa, Salem, Fatima, Sanchez, Rebecca, Sanders, Muave, Sanderson, Tayler, Sandhu, Sophie, Sanford, Katelyn, Santangelo, Susan, Santulli, Madeline, Sarver, Dustin, Savage, Madeline, Scherr, Jessica, Schneider, Hoa, Schools, Hayley, Schoonover, Gregory, Schultz, Robert, Sebolt, Cheyanne, Shaffer, Rebecca, Shameen, Sana, Sherard, Curry, Shikov, Roman, Shillington, Amelle, Shir, Mojeeb, Shocklee, Amanda, Shrier, Clara, Shulman, Lisa, Siegel, Matt, Simon, Andrea, Simon, Laura, Singh, Arushi, Singh, Vini, Smalley, Devin, Smith, Kaitlin, Smith, Chris, Smith, Ashlyn, Soorya, Latha, Soscia, Julia, Soucy, Aubrie, Stchur, Laura, Steele, Morgan, Srishyla, Diksha, Stamps, Danielle, Sussman, Nicole, Swanson, Amy, Sweeney, Megan, Sziklay, Anthony, Tafolla, Maira, Taiba, Jabeen, Takahashi, Nicole, Terroso, Sydney, Strathearn, Camilla, Thomas, Taylor, Thompson, Samantha, Touchette, Ellyn, Townsend, Laina, Trog, Madison, Tsai, Katherine, Tseng, Angela, Tshering, Paullani, Tso, Ivy, Valicenti-Mcdermott, Maria, VanMetre, Bonnie, VanWade, Candace, Turecki, Samuel, Vargo, Kerrigan, Vattuone, Cristiana, Veenstra-Vanderweele, Jeremy, Vehorn, Alison, Benitez Velazquez, Alan Jesus, Verdi, Mary, Villalobos, Michele, Vrittamani, Lakshmi, Wainer, Allison, Wallace, Jermel, Walston, Corrie, Wang, Jiayaho, Ward, Audrey, Warren, Zachary, Washington, Katherine, Westerkamp, Grace, White, Sabrina, Wink, Logan, Winoto, Fiona, Winters, Sarah, Wodka, Ericka, Xavier, Samantha, Xu, Sidi, Yang, Yi, Yang, WhaJames, Yang, Amy, Yinger, Meredith, Yu, Timothy, Zaro, Christopher, Zha, Cindy, Zhang, Haicang, Zhao, Haoquan, Zick, Allyson, Salmon, Lauren Ziegelmayer, Wright, Jessica R., Astrovskaya, Irina, Barns, Sarah D., Goler, Alexandra, Zhou, Xueya, Shu, Chang, Snyder, LeeAnne Green, Han, Bing, Shen, Yufeng, Volfovsky, Natalia, Hall, Jacob B., Feliciano, Pamela, and Chung, Wendy K.

Published
2024
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12. Modeling of Intracellular Taurine Levels Associated with Ovarian Cancer Reveals Activation of p53, ERK, mTOR and DNA-Damage-Sensing-Dependent Cell Protection.

Author

Centeno, Daniel, Farsinejad, Sadaf, Kochetkova, Elena, Volpari, Tatiana, Gladych-Macioszek, Aleksandra, Klupczynska-Gabryszak, Agnieszka, Polotaye, Teagan, Greenberg, Michael, Kung, Douglas, Hyde, Emily, Alshehri, Sarah, Pavlovic, Tonja, Sullivan, William, Plewa, Szymon, Vakifahmetoglu-Norberg, Helin, Monsma Jr., Frederick J., Muller, Patricia A. J., Matysiak, Jan, Zaborowski, Mikołaj Piotr, and DiFeo, Analisa

Abstract

Taurine, a non-proteogenic amino acid and commonly used nutritional supplement, can protect various tissues from degeneration associated with the action of the DNA-damaging chemotherapeutic agent cisplatin. Whether and how taurine protects human ovarian cancer (OC) cells from DNA damage caused by cisplatin is not well understood. We found that OC ascites-derived cells contained significantly more intracellular taurine than cell culture-modeled OC. In culture, elevation of intracellular taurine concentration to OC ascites-cell-associated levels suppressed proliferation of various OC cell lines and patient-derived organoids, reduced glycolysis, and induced cell protection from cisplatin. Taurine cell protection was associated with decreased DNA damage in response to cisplatin. A combination of RNA sequencing, reverse-phase protein arrays, live-cell microscopy, flow cytometry, and biochemical validation experiments provided evidence for taurine-mediated induction of mutant or wild-type p53 binding to DNA, activation of p53 effectors involved in negative regulation of the cell cycle (p21), and glycolysis (TIGAR). Paradoxically, taurine's suppression of cell proliferation was associated with activation of pro-mitogenic signal transduction including ERK, mTOR, and increased mRNA expression of major DNA damage-sensing molecules such as DNAPK, ATM and ATR. While inhibition of ERK or p53 did not interfere with taurine's ability to protect cells from cisplatin, suppression of mTOR with Torin2, a clinically relevant inhibitor that also targets DNAPK and ATM/ATR, broke taurine's cell protection. Our studies implicate that elevation of intracellular taurine could suppress cell growth and metabolism, and activate cell protective mechanisms involving mTOR and DNA damage-sensing signal transducti. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Beyond methane, new frontiers in anaerobic microbial hydrocarbon utilizing pathways.

Author

Sarno, Natalie, Hyde, Emily, De Anda, Valerie, and Baker, Brett J.

Subjects
*HYDROCARBONS, *CLIMATE change mitigation, *METHANE, *TETRADECANE, *METHANE as fuel, *ALKANES, *MICROBIAL communities, *SOIL microbiology
Abstract

Alkanes, single carbon methane to long‐chain hydrocarbons (e.g. hexadecane and tetradecane), are important carbon sources to anaerobic microbial communities. In anoxic environments, archaea are known to utilize and produce methane via the methyl‐coenzyme M reductase enzyme (MCR). Recent explorations of new environments, like deep sea sediments, that have coupled metagenomics and cultivation experiments revealed divergent MCRs, also referred to as alkyl‐coenzyme M reductases (ACRs) in archaea, with similar mechanisms as the C1 utilizing canonical MCR mechanism. These ACR enzymes have been shown to activate other alkanes such as ethane, propane and butane for subsequent degradation. The reversibility of canonical MCRs suggests that these non‐methane‐activating homologues (ACRs) might have similar reversibility, perhaps mediated by undiscovered lineages that produce alkanes under certain conditions. The discovery of these alternative alkane utilization pathways holds significant promise for a breadth of potential biotechnological applications in bioremediation, energy production and climate change mitigation. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Organic sulfur from source to sink in low‐sulfate Lake Superior

Author

Phillips, Alexandra A., primary, Ulloa, Imanol, additional, Hyde, Emily, additional, Agnich, Julia, additional, Sharpnack, Lewis, additional, O'Malley, Katherine G., additional, Webb, Samuel M., additional, Schreiner, Kathryn M., additional, Sheik, Cody S., additional, Katsev, Sergei, additional, and Raven, Morgan Reed, additional

Published
2023
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17. Organic sulfur from source to sink in low-sulfate Lake Superior

Author

Phillips, Alexandra A, primary, Ulloa, Imanol, additional, Hyde, Emily, additional, Agnich, Julia, additional, Sharpnack, Lewis, additional, O'Malley, Katherine G, additional, Webb, Samuel M, additional, Schreiner, Kathryn M, additional, Sheik, Cody S, additional, Katsev, Sergei, additional, and Raven, Morgan Reed, additional

Published
2023
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24. The Dietary Supplement Taurine Suppresses Ovarian Cancer Growth

Author

Centeno, Daniel, primary, Farsinejad, Sadaf, additional, Kochetkova, Elena, additional, Volpari, Tatiana, additional, Klupczynska-Gabryszak, Agnieszka, additional, Kung, Douglas, additional, Polotaye, Teagan, additional, Hyde, Emily, additional, Pavlovic, Tonja, additional, Alshehri, Sarah, additional, Sullivan, William, additional, Plewa, Szymon, additional, Monsma, Frederick J, additional, Matysiak, Jan, additional, Zaborowski, Mikolaj, additional, Difeo, Analisa, additional, Martin, Laura A., additional, Norberg, Erik, additional, and Iwanicki, Marcin, additional

Published
2023
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27. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

Author

Ashley, Brogan, primary, Simner, Claire, primary, Manousopoulou, Antigoni, additional, Jenkinson, Carl, additional, Hey, Felicity, additional, Frost, Jennifer M, additional, Rezwan, Faisal I, additional, White, Cory H, additional, Lofthouse, Emma M, additional, Hyde, Emily, additional, Cooke, Laura DF, additional, Barton, Sheila, additional, Mahon, Pamela, additional, Curtis, Elizabeth M, additional, Moon, Rebecca J, additional, Crozier, Sarah R, additional, Inskip, Hazel M, additional, Godfrey, Keith M, additional, Holloway, John W, additional, Cooper, Cyrus, additional, Jones, Kerry S, additional, Lewis, Rohan M, additional, Hewison, Martin, additional, Garbis, Spiros DD, additional, Branco, Miguel R, additional, Harvey, Nicholas C, additional, and Cleal, Jane K, additional

Published
2022
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29. Author response: Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

Author

Ashley, Brogan, primary, Simner, Claire, primary, Manousopoulou, Antigoni, additional, Jenkinson, Carl, additional, Hey, Felicity, additional, Frost, Jennifer M, additional, Rezwan, Faisal I, additional, White, Cory H, additional, Lofthouse, Emma M, additional, Hyde, Emily, additional, Cooke, Laura DF, additional, Barton, Sheila, additional, Mahon, Pamela, additional, Curtis, Elizabeth M, additional, Moon, Rebecca J, additional, Crozier, Sarah R, additional, Inskip, Hazel M, additional, Godfrey, Keith M, additional, Holloway, John W, additional, Cooper, Cyrus, additional, Jones, Kerry S, additional, Lewis, Rohan M, additional, Hewison, Martin, additional, Garbis, Spiros DD, additional, Branco, Miguel R, additional, Harvey, Nicholas C, additional, and Cleal, Jane K, additional

Published
2021
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30. "Just think of it as sexercise" – healthcare providers' perceptions about sexual health education in cardiac rehabilitation programs.

Author

Hyde, Emily K., Martin, Donna E., Rieger, Kendra L., and Malone, Reece

Subjects
*TREATMENT of acute coronary syndrome, *SAMPLE size (Statistics), *ATTITUDES of medical personnel, *RESEARCH methodology, *INTERVIEWING, *QUALITATIVE research, *CONCEPTUAL structures, *PHYSICAL activity, *CARDIAC rehabilitation, *RESEARCH funding, *DESCRIPTIVE statistics, *COMMUNICATION, *STATISTICAL sampling, *SOCIODEMOGRAPHIC factors, *THEMATIC analysis, *SEXUAL health
Abstract

Sexual health education (SHE) is an important rehabilitation component for acute coronary syndrome (ACS) survivors but is not routinely provided. This study's purpose was to explore healthcare providers' experiences of providing SHE to ACS survivors in cardiac rehabilitation programs to identify best practices. This qualitative study used convenience sampling and an interpretive descriptive design. Inclusion criteria were a healthcare provider employed within a cardiac rehabilitation program in a Western Canadian province. Eight cardiac rehabilitation healthcare providers volunteered to participate. The first author conducted semi-structured, digitally recorded interviews that were transcribed verbatim. The interviews were guided by a semi-structured interview guide anchored in the strengths-based, sex positive guiding frameworks. A reflective journal and socio-demographic forms served as additional data sources. Data were analyzed using open, axial, and selective coding as well as constant comparative analysis. Credibility was ensured through peer-reviewed evaluation criteria. Eight healthcare providers participated in the study. Participants equated sexuality and sexual health with physical activity and physical health. Findings identified philosophical perspectives and several barriers and facilitators that impact SHE provision. Participants offered strategies that may be used in practice and their recommendations provide a beginning foundation to improve cardiac rehabilitation programs and the health of ACS survivors. Healthcare providers in cardiac rehabilitation programs described their SHE experiences as "just think of it as sexercise." Facilitation of SHE is important as previous studies found that SHE may reduce fear, depression, and anxiety and increase the return to sexual activity among ACS survivors. Sexual health doesn't need to be a taboo topic. Approach sexual health conversations by thinking of it as "sexercise". Don't let silos stop sexual health education – talk to your coworkers and patients about sexual health. Knowledge about sexual health, timing of sexual health education, and communication between care providers and patients are important factors in delivery of sexual health education. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Nature should be the model for microbial sciences.

Author

Baker, Brett J., Hyde, Emily, and Leão, Pedro

Abstract

Until recently, microbiologists have relied on cultures to understand the microbial world. As a result, model organisms have been the focus of research into understanding Bacteria and Archaea at a molecular level. Diversity surveys and metagenomic sequencing have revealed that these model species are often present in low abundance in the environment; instead, there are microbial taxa that are cosmopolitan in nature. Due to the numerical dominance of these microorganisms and the size of their habitats, these lineages comprise mind-boggling population sizes upward of 1028 cells on the planet. Many of these dominant groups have cultured representatives and have been shown to be involved in mediating key processes in nature. Given their importance and the increasing need to understand changes due to climate change, we propose that members of Nitrosophaerota (Nitrosopumilus maritimus), SAR11 (Pelagibacter ubique), Hadesarchaeia, Bathyarchaeia, and others become models in the future. Abundance should not be the only measure of a good model system; there are other organisms that are well suited to advance our understanding of ecology and evolution. For example, the most well-studied symbiotic bacteria, like Buchnera, Aliivibrio, and Rhizobium, should be models for understanding host-associations. Also, there are organisms that hold new insights into major transitions in the evolution of life on the planet like the Asgard Archaea (Heimdallarchaeia). Innovations in a variety of in situ techniques have enabled us to circumvent culturing when studying everything from genetics to physiology. Our deepest understanding of microbiology and its impact on the planet will come from studying these microbes in nature. Laboratory-based studies must be grounded in nature, not the other way around. [ABSTRACT FROM AUTHOR]

Published
2024
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35. Placental uptake and metabolism of 25(OH)Vitamin D determines its activity within the fetoplacental unit

Author

Ashley, Brogan, primary, Simner, Claire, additional, Manousopoulou, Antigoni, additional, Jenkinson, Carl, additional, Hey, Felicity, additional, Frost, Jennifer M, additional, Rezwan, Faisal I, additional, White, Cory H, additional, Lofthouse, Emma, additional, Hyde, Emily, additional, Cooke, Laura, additional, Barton, Sheila, additional, Mahon, Pamela, additional, Curtis, Elizabeth M, additional, Moon, Rebecca J, additional, Crozier, Sarah R, additional, Inskip, Hazel M, additional, Godfrey, Keith M, additional, Holloway, John W, additional, Cooper, Cyrus, additional, Jones, Kerry S, additional, Lewis, Rohan M, additional, Hewison, Martin, additional, Garbis, Spiros D, additional, Branco, Miguel R, additional, Harvey, Nicholas C, additional, and Cleal, Jane K, additional

Published
2021
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36. Return of genetic research results in 21,532 individuals with autism

Author

Wright, Jessica R., Astrovskaya, Irina, Barns, Sarah D., Goler, Alexandra, Zhou, Xueya, Shu, Chang, Snyder, LeeAnne Green, Han, Bing, Aarrestad, Alexandria, Abbeduto, Leonard, Aberbach, Gabriella, Aberle, Shelley, Adegbite, Adediwura, Adeniji, Debbie, Aguilar, Maria, Ahlers, Kaitlyn, Albright, Charles, Alessandri, Michael, Algaze, Zach, Alkazi, Jasem, Amador, Raquel, Amaral, David, Amon, Logan, Amundsen, Leonor, Andrus, Alicia, Anglo, Claudine, Annett, Robert, Arar, Adam, Arnold, Jonathan, Arriaga, Ivette, Arzate, Eduardo, Ashley, Raven, Aslamy, Leilemah, Baalman, Kelli, Baer, Melissa, Bahi, Ethan, Bailey, Joshua, Baldlock, Zachary, Banks, Grabrielle, Baraghoshi, Gabriele, Bardett, Nicole, Barrett, Mallory, Bartholomew, Yan, Bates, Heidi, Beard, Katie, Becerra, Juana, Beckwith, Malia, Beechan, Paige, Beeson, Landon, Beeson, Josh, Bell, Brandi, Belli, Monica, Bentley, Dawn, Berger, Natalie, Berman, Anna, Bernier, Raphael, Berry-Kravis, Elizabeth, Berwanger, Mary, Birdwell, Shelby, Blank, Elizabeth, Bond, Rebecca, Booker, Stephanie, Bordofsky, Aniela, Bower, Erin, Bowers, Lukas, Bradley, Catherine, Brayer, Heather, Brewster, Stephanie, Brown, Hallie, Brown, Alison, Brown, Melissa, Buck, Catherine, Buescher, Cate, Bullon, Kayleigh, Buraima, Joy, Butter, Eric, Caamano, Amalia, Cacciato, Nicole, CaI, Wenteng, Calderon, Norma, Callahan, Kristen, Camba, Alexies, Campo-Soria, Claudia, Caprara, Giuliana, Carbone, Paul, Carpenter, Laura, Carpenter, Sarah, Casseus, Myriam, Casten, Lucas, Catherine, Sullivan, Chappo, Ashley, Chavez, Kimberly, Cheathem-Johnson, Randi, Chen, Tia, Chintalapalli, Sharmista, Cho, Daniel, Choi, Y.B., Clark, Nia, Clark, Renee, Coffman, Marika, Coleman, Laura, Coleman, Kendra, Collins, Alister, Columbi, Costanza, Comitre, Joaquin, Constant, Stephanie, Contra, Arin, Conyers, Sarah, Cooper, Lindsey, Cooper, Cameron, Coppola, Leigh, Corlett, Allison, Corrales, Lady, Correa, Dahriana, Cottrell, Hannah, Coughlin, Michelle, Courchesne, Eric, Coury, Dan, Crocetti, Deana, Croson, Carrie, Crowell, Judith, Cubells, Joseph, Cunningham, Sean, Currin, Mary, Cutri, Michele, D'Ambrosi, Sophia, David, Giancarla, Davis, Ayana, Davis, Sabrina, Decius, Nickelle, Delaporte, Jennifer, DeMarco, Lindsey, Dennis, Brandy, Deronda, Alyssa, Dhawan, Esha, Dichter, Gabriel, Doan, Ryan, Dominick, Kelli, Ortega, Leonardo Dominquez, Doyle, Erin, Drayton, Andrea, DuBois, Megan, Dudley, Johnny, Duhon, Gabrielle, Duncan, Grabrielle, Duncan, Amie, Dunlevy, Megan, Dyer, Meaghan, Earl, Rachel, Edmonson, Catherine, Eldred, Sara, Elliott, Nelita, Emery, Brooke, Enright, Barbara, Erb, Sarah, Erickson, Craig, Esler, Amy, Estevez, Liza, Fanta, Anne, Fassler, Carrie, Fatemi, Ali, Fazal, Faris, Featherston, Marilyn, Ferguson, Jonathan, Fish, Angela, Fitzgerald, Kate, Flores, Kathleen, Fombonne, Eric, Foster, Margaret, Fowler, Tiffany, Fox, Emma, Fox, Emily, Francis, Sunday, Frayne, Margot, Froman, Sierra, Fuller, Laura, Galbraith, Virginia, Gallimore, Dakota, Gambrell, Ariana, Gazestani, Vahid, Geisheker, Madeleine R., Gerdts, Jennifer, Geschwind, Daniel, Ghaziuddin, Mohammad, Ghina, Haidar, Given, Erin, Goetz, Mykayla, Gong, Jared, Gonring, Kelsey, Gonzalez, Natalia, Gonzalez, Antonio, Goodwill, Ellie, Gordon, Rachel, Graham, Carter, Gray, Catherine, Grimes, Ellen, Griswold, Anthony, Gu, Pan, Guilfoyle, Janna, Gulsrud, Amanda, Gunderson, Jaclyn, Gunter, Chris, Gupta, Sanya, Gupta, Abha, Gutierrez, Anibal, Gwynette, Frampton, Haidar, Ghina, Hale, Melissa, Haley, Monica, Hall, Lauren K., Hamer, Kira, Hamilton, Piper, Hanna, Nathan, Hardan, Antonio, Harkins, Christina, Harrell, Eldric, Harris, Jill, Harris, Nina, Hayes, Caitlin, Hayse, Braden, Heckers, Teryn, Heerwagen, Kathryn, Hennelly, Daniela, Herbert, Lynette, Hermle, Luke, Hernandez, Briana, Herrera, Clara, Hess, Amy, Heyman, Michelle, Higgins, Lorrin, Phillips, Brittani Hilscher, Hirst, Kathy, Ho, Theodore, Hoffman, Emily, Hojlo, Margaret, Honaker, Makayla, Hong, Michael, Hooks, Gregory, Horner, Susannah, Horton, Danielle, Hounchell, Melanie, Howes, Dain, Huang-Storm, Lark, Hunter, Samantha, Hutter, Hanna, Hyde, Emily, Ibanez, Teresa, Ingram, Kelly, Istephanous, Dalia, Jacob, Suma, Jarratt, Andrea, Jelinek, Anna, Johnson, Mary, Jones, Mya, Jones, Garland, Jones, Mark, Jorgenson, Alissa, Judge, Jessyca, Kalb, Luther, Kalmus, Taylor, Kang, Sungeun, Kangas, Elizabeth, Kanne, Stephen, Kaplan, Hannah, Khan, Sara, Kim, Sophy, Kim, Annes, Kitaygordsky, Alex, Klaiman, Cheryl, Klever, Adam, Koene, Hope, Koomar, Tanner, Koza, Melinda, Kramer, Sydney, Krushena, Meghan, Kurtz-Nelson, Eva, Lamarche, Elena, Lampert, Erica, Lamy, Martine, Landa, Rebecca, Lebron-Cruz, Alexa, Lechniak, Holly, Lee, Soo, Leight, Bruce, Lerner, Matthew, Lesher, Laurie, Lewis, Courtney, Li, Hai, Li, Deana, Libove, Robin, Lillie, Natasha, Limon, Danica, Limpoco, Desi, Lin, Melody, Littlefield, Sandy, Lobisi, Brandon, Locarno, Laura, Long, Nancy, Long, Bailey, Long, Kennadie, Lopez, Marilyn, Lovering, Taylor, Lozano, Ivana, Lucio, Daniella, Luo, Addie, Luu, My-Linh, Lyon, Audrey, Ma, Julia, Madi, Natalie, Malloch, Lacy, Mankaryous, Reanna, Manning, Patricia, Mantey, Alvin, Marini, Richard, Marsden, Alexandra, Marwali, Clarissa, Marzano, Gabriela, Mason, Andrew, Mastel, Sarah, Mathai, Sheena, Matthews, Emily, Matusoff, Emma, Maxim, Clara, McCarthy, Caitlin, McClellen, Lynn, Mccoy, Nicole, McCullough, Kaylen, McDonald, Brooke, McGalliard, Julie, McIntyre, Anne-Marie, McKenna, Brooke, McKenzie, Alexander, McTaggart, Megan, Meinen, Hannah, Melnyk, Sophia, Miceli, Alexandra, Michaels, Sarah, Michaelson, Jacob, Milan, Estefania, Miller, Melissa, Milliken, Anna, Minton, Kyla, Mitchell, Terry, Gunn, Amanda Moffitt, Mohiuddin, Sarah, Money, Gina, Montezuma, Jessie, Mooney, Lindsey, Moore, Margo, Morales-Lara, Amy, Morgan, Kelly, Morotti, Hadley, Morrier, Michael, Munoz, Maria, Lavanderos, Ambar Munoz, Murali, Shwetha, Murillo, Karla, Murray, Kailey, Myhre, Erin, Neely, Jason, Neuhaus, Emily, Newman, Olivia, Nguyen, Richard, Nguyen, Victoria, Nichols, Evelyn, Nicholson, Amy, Niederhauser, Melanie, Norris, Megan, Norton, Shai, Nowell, Kerri, O’Brien, Kaela, O’Meara, Mitchell, O’Neil, Molly, O'Roak, Brian, Ocampo, Edith, Ochoa-Lubinoff, Cesar, Oft, Anna, Orobio, Jessica, Ortiz, Crissy, Ousley, Opal, Oyeyemi, Motunrayo, Pacheco, Lillian, Palacios, Valeria, Palmer, Samiza, Palmeri, Isabella, Pama, Katrina, Pandey, Juhi, Paolicelli, Anna Marie, Parker, Jaylaan, Patterson, Morgan, Pawlowski, Katherine, Pedapati, Ernest, Pepper, Michah, Perrin, Jeremy, Peura, Christine, Phillips, Diamond, Pierce, Karen, Piven, Joseph, Plate, Juhi, Polanco, Jose, Pott-Schmidt, Natalie, Pramparo, Tiziano, Pratt, Taleen, Prock, Lisa, White, Stormi Pulver, Qi, Hongjian, Qiu, Shanping, Queen, Eva, Questel, Marcia, Quinones, Ashley, Rambeck, Desiree, Randall, Shelley, Ranganathan, Vaikunt, Raymond, Laurie, Rayos, Madelyn, Real, Kelly, Rhea, Anna, Rice, Catherine, Richardson, Harper, Riffle, Stacy, Robertson, Tracy, Roby, Erin, Rocha, Ana, Roche, Casey, Rodriguez, Nicki, Rodriguez, Bianca, Roeder, Katherine, Rojas, Daniela, Rosewater, Jacob, Rosselott, Hilary, Runyan, Payton, Russo, Nicole, Rutter, Tara, Ruzzo, Elizabeth, Sahin, Mustafa, Salem, Fatima, Sanchez, Rebecca, Sanders, Muave, Sanderson, Tayler, Sandhu, Sophie, Sanford, Katelyn, Santangelo, Susan, Santulli, Madeline, Sarver, Dustin, Savage, Madeline, Scherr, Jessica, Schneider, Hoa, Schools, Hayley, Schoonover, Gregory, Schultz, Robert, Sebolt, Cheyanne, Shaffer, Rebecca, Shameen, Sana, Sherard, Curry, Shikov, Roman, Shillington, Amelle, Shir, Mojeeb, Shocklee, Amanda, Shrier, Clara, Shulman, Lisa, Siegel, Matt, Simon, Andrea, Simon, Laura, Singh, Arushi, Singh, Vini, Smalley, Devin, Smith, Kaitlin, Smith, Chris, Smith, Ashlyn, Soorya, Latha, Soscia, Julia, Soucy, Aubrie, Stchur, Laura, Steele, Morgan, Srishyla, Diksha, Stamps, Danielle, Sussman, Nicole, Swanson, Amy, Sweeney, Megan, Sziklay, Anthony, Tafolla, Maira, Taiba, Jabeen, Takahashi, Nicole, Terroso, Sydney, Strathearn, Camilla, Thomas, Taylor, Thompson, Samantha, Touchette, Ellyn, Townsend, Laina, Trog, Madison, Tsai, Katherine, Tseng, Angela, Tshering, Paullani, Tso, Ivy, Valicenti-Mcdermott, Maria, VanMetre, Bonnie, VanWade, Candace, Turecki, Samuel, Vargo, Kerrigan, Vattuone, Cristiana, Veenstra-Vanderweele, Jeremy, Vehorn, Alison, Benitez Velazquez, Alan Jesus, Verdi, Mary, Villalobos, Michele, Vrittamani, Lakshmi, Wainer, Allison, Wallace, Jermel, Walston, Corrie, Wang, Jiayaho, Ward, Audrey, Warren, Zachary, Washington, Katherine, Westerkamp, Grace, White, Sabrina, Wink, Logan, Winoto, Fiona, Winters, Sarah, Wodka, Ericka, Xavier, Samantha, Xu, Sidi, Yang, Yi, Yang, WhaJames, Yang, Amy, Yinger, Meredith, Yu, Timothy, Zaro, Christopher, Zha, Cindy, Zhang, Haicang, Zhao, Haoquan, Zick, Allyson, Salmon, Lauren Ziegelmayer, Shen, Yufeng, Volfovsky, Natalia, Hall, Jacob B., Feliciano, Pamela, and Chung, Wendy K.

Abstract

The aim of this study is to identify likely pathogenic (LP) and pathogenic (P) genetic results for autism that can be returned to participants in SPARK (SPARKforAutism.org): a large recontactable cohort of people with autism in the United States. We also describe the process to return these clinically confirmed genetic findings.

Published
2024
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37. Exploring the provision of sexual health education for adults with acute coronary syndrome in cardiac rehabilitation programs

Author

Reiger, Kendra (Nursing) Malone, Reece (Sexuality Consultants and Support Services Manitoba, Inc.), Martin, Donna (Nursing), Hyde, Emily, Reiger, Kendra (Nursing) Malone, Reece (Sexuality Consultants and Support Services Manitoba, Inc.), Martin, Donna (Nursing), and Hyde, Emily

Abstract

Annually, acute coronary syndrome (ACS) is diagnosed in 63,000 Canadians, and 73% survive. Although practice guidelines and scientific statements clearly identify the importance of providing sexual health education to ACS survivors, it is not routinely provided. By not including sexual health education to ACS survivors, this patient population may experience higher rates of fear, depression, and anxiety. There is a paucity of research literature about the successful provision of sexual health education post-ACS. The purpose of this thesis was to provide an overview of the current state of the literature related to sexual health education to inform health care providers about factors shaping sexual health education for ACS survivors and explore healthcare providers’ experiences providing sexual health education to ACS survivors. A scoping review was completed, which identified the limited provision of sexual health education along with macro, meso, and micro-level factors influencing the provision of sexual health education. A gap in the literature was noted related to the lack of use of a sex positive lens when investigating the provision of sexual health education to ACS survivors. An interpretive descriptive study was then completed using a strengths-based approach and guided by sex positivity. Semi-structured, digitally recorded interviews were conducted with eight healthcare providers, half of whom were nurses. Additional data sources were a sociodemographic form and a reflective journal. Data were analysed using open, axial, then selective coding and constant comparative analysis. Key barriers and facilitators were identified and categorized according to sex and sexuality, the individual, and the institution. The findings may offer effective strategies to healthcare providers for use in their practice and provide a foundation to revisit and revise policy and programs in cardiac rehabilitation. Successfully providing sexual health education may reduce fear, depr

Published
2020

40. Decolonizing the Cold War.

Author

Hyde, Emily

Subjects
AT Penpoint: African Literatures, Postcolonial Studies & the Cold War (Book), POPESCU, Monica, NGUGI wa Thiong'o, 1938-, BLACK Orpheus (Periodical), TRANSITION (Periodical)
Abstract

A literary criticism of the book "At Penpoint: African Literatures, Postcolonial Studies, and the Cold War" by Monica Popescu is presented. Topics discussed include influence of Ngũgĩ wa Thiong'o, a Kenyan Kikuyu writer, on the title of the book; scholarly field of African literature including magazines such as "Black Orpheus" in Nigeria and "Transition" in Uganda; and Cold War culture and ideology along with aesthetic decolonization in Africa.

Published
2021

47. Surface Charge Control through the Reversible Adsorptionof a Biomimetic Polymer on Silica Particles.

Author

Hyde, Emily D. E., Moreno-Atanasio, Roberto, Millner, Paul A., and Neville, Frances

Subjects
*SILICA, *BIOMIMETIC polymers, *SURFACE charges, *ABSORPTION & adsorption of polymers, *BIOCHEMICAL substrates, *DRUG delivery systems
Abstract

The control of the physicochemicalproperties of silica particlesis of paramount importance to achieve full functionality in specificapplications. A novel facile method of silica particle synthesis,requiring only two reactants, was developed. Control of the surfacecharge of these newly synthesized silica particles was achieved viathe rapid electrostatic adsorption and acidic desorption of the branched,biomimetic polymer, polyethylenimine (PEI). Successful adsorption/desorptionof PEI was supported by ATR-FTIR spectra, an adsorption isotherm,and ζ-potential curves. PEI adsorption above a threshold PEIconcentration was determined to categorically change the topographyof the silica particles’ ζ-potential curve. The resultsfrom our study convey a rapid, reversible, and reliable method ofsilica particle surface charge control. This may be of particularuse in tailoring surface interactions of silica or silica-coated particlesfor applications in drug delivery, biomedical technologies, catalysis,and coatings. [ABSTRACT FROM AUTHOR]

Published
2015
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48. Multi-stakeholder Recommendations for Supporting Patients and Families Transitioning from Pediatric to Adult Congenital Heart Disease Care

Author

Hyde, Emily K., Schultz, Annette S.H., Ducas, Robin, Soni, Reeni, Bekkering, Holly, Barker, Dawn, Klippenstein, Andrea, Dave, Mudra, Frechette, Chloe, St. Goddard-Frechette, Joanne, Lester, Lori, Mclarty, Shelly, and Chudyk, Anna M.

Abstract

Transitioning from pediatric to adult congenital heart disease (CHD) care is a high-risk time for being lost to follow-up. Existing CHD transition programs have not included patients, caregivers, and healthcare providers as partners in their development. This study aimed to develop recommendations for a CHD transition program driven by lived and clinical experiences.

Published
2023
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49. Use of metagenomics and metatranscriptomics to determine the influence of organic sulfur compounds on the sulfur cycle in the sediment of a low-sulfate freshwater system

Author

Hyde, Emily

Subjects
Freshwater, Metabolism, Metagenomics, Metatranscriptomics, Organic, Sulfur
Abstract

The sulfur cycle is an important and complex biogeochemical cycle involving both inorganic and organic species in both oxic and anoxic environments. However, due to the lack of research regarding the sulfur cycle in freshwater systems, the contributions of organic sulfur compounds to the sulfur cycle are underappreciated. Recent studies have suggested organic sulfur compounds likely fuels sulfate reduction, especially in low-sulfate oligotrophic freshwater systems, through a possible cryptic sulfur cycle. To determine the contributions that organic sulfur compounds may have in this environment, we used Lake Superior sediment to analyze for the presence of and expression of sulfur cycling genes. In these metagenomes, we found genes for sulfur reduction, oxidation and organic sulfur compound degradation. Metabolic pathway analysis showed presence of not only organic sulfur compounds contributing to the sulfur cycle, but tetrathionate, thiosulfate, and polysulfides playing a role as well. Using Lake Superior sediments, we also conducted sediment incubations to measure the biotransformation capability of sulfur-containing amino acids, sulfonates, and an analog for a common sulfolipid. Taurine and sodium dodecyl sulfate produced higher sulfate values in incubations, suggesting that microbes prefer sulfonates over sulfur-containing amino acids, in addition to a possible partiality towards oxidized organic sulfur compounds over reduced forms regarding sulfate production. The preference of sulfonates is supported by the commonality of taurine genes present as well as the low, but present transcription values of sulfoacetaldehyde degradation. While sulfur-containing amino acids do not produce sulfate values near that of sulfonates or sulfolipids, there are still present and transcriptionally active genes that can contribute to sulfate reduction in the system. Regarding methyl-sulfurs, metatranscriptomic data shows that methyl-mercaptan (intermediate within dimethyl sulfide and methionine degradation) degradation is transcriptionally active across genomes. By combining biotransformation incubation data, metagenomics, and metatranscriptomics, we analyzed how methylated sulfurs, sulfur-containing amino acids and sulfonates can fuel a sulfur cycle in a low-sulfate environment, informing us on how pathways may have operated in our Earth’s geologic past.

Published
2020

50. Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

Author

Emily Hyde, Sheila J. Barton, Miguel R. Branco, Cory H. White, Spiros D Garbis, Claire Simner, Faisal I. Rezwan, Nicholas C. Harvey, P A Mahon, Rebecca J Moon, Felicity Hey, Kerry S Jones, Martin Hewison, Cyrus Cooper, John W. Holloway, Antigoni Manousopoulou, Elizabeth M Curtis, Carl Jenkinson, Hazel Inskip, Sarah Crozier, Rohan M. Lewis, Brogan Ashley, Emma M. Lofthouse, Laura Cooke, Jennifer M. Frost, Jane K. Cleal, Keith M. Godfrey, Jones, Kerry [0000-0002-7380-9797], Apollo - University of Cambridge Repository, Jenkinson, Carl [0000-0002-1838-5282], Hey, Felicity [0000-0003-2695-4817], Frost, Jennifer M [0000-0002-3057-6313], Rezwan, Faisal I [0000-0001-9921-222X], White, Cory H [0000-0002-1619-0174], Lofthouse, Emma M [0000-0002-0175-5590], Hyde, Emily [0000-0001-5084-3709], Cooke, Laura DF [0000-0002-8099-9437], Barton, Sheila [0000-0003-4963-4242], Mahon, Pamela [0000-0003-0661-572X], Curtis, Elizabeth M [0000-0002-5147-0550], Moon, Rebecca J [0000-0003-2334-2284], Crozier, Sarah R [0000-0002-9524-1127], Inskip, Hazel M [0000-0001-8897-1749], Godfrey, Keith M [0000-0002-4643-0618], Holloway, John W [0000-0001-9998-0464], Cooper, Cyrus [0000-0003-3510-0709], Lewis, Rohan M [0000-0003-4044-9104], Hewison, Martin [0000-0001-5806-9690], Garbis, Spiros DD [0000-0002-1050-0805], Branco, Miguel R [0000-0001-9447-1548], Harvey, Nicholas C [0000-0002-8194-2512], and Cleal, Jane K [0000-0001-7978-4327]

Subjects
medicine.medical_specialty, placenta, 030209 endocrinology & metabolism, Endocytosis, General Biochemistry, Genetics and Molecular Biology, Transcriptome, 03 medical and health sciences, transcriptomics, 0302 clinical medicine, Fetus, Pregnancy, Placenta, Internal medicine, medicine, Vitamin D and neurology, Humans, Epigenetics, Vitamin D, 030304 developmental biology, Calcifediol, 0303 health sciences, General Immunology and Microbiology, epigenetics, Chemistry, General Neuroscience, General Medicine, Metabolism, Vitamins, medicine.disease, 3. Good health, Endocrinology, medicine.anatomical_structure, fetal programming, embryonic structures, Female, General Economics, Econometrics and Finance, Research Article, Developmental Biology, Human
Abstract

Funder: Gerald Kerkut Charitable Trust; FundRef: http://dx.doi.org/10.13039/100012166, Funder: Rank Prize, Funder: NIHR Clinical Lectureship, Pregnancy 25-hydroxyvitamin D [25(OH)D] concentrations are associated with maternal and fetal health outcomes. Using physiological human placental perfusion and villous explants, we investigate the role of the placenta in regulating the relationships between maternal 25(OH)D and fetal physiology. We demonstrate active placental uptake of 25(OH)D3 by endocytosis, placental metabolism of 25(OH)D3 into 24,25-dihydroxyvitamin D3 and active 1,25-dihydroxyvitamin D [1,25(OH)2D3], with subsequent release of these metabolites into both the maternal and fetal circulations. Active placental transport of 25(OH)D3 and synthesis of 1,25(OH)2D3 demonstrate that fetal supply is dependent on placental function rather than simply the availability of maternal 25(OH)D3. We demonstrate that 25(OH)D3 exposure induces rapid effects on the placental transcriptome and proteome. These map to multiple pathways central to placental function and thereby fetal development, independent of vitamin D transfer. Our data suggest that the underlying epigenetic landscape helps dictate the transcriptional response to vitamin D treatment. This is the first quantitative study demonstrating vitamin D transfer and metabolism by the human placenta, with widespread effects on the placenta itself. These data demonstrate a complex interplay between vitamin D and the placenta and will inform future interventions using vitamin D to support fetal development and maternal adaptations to pregnancy., CS was funded by a Gerald Kerkut Charitable Trust studentship and BA by Rank Prize and University of Southampton Vice Chancellor���s Studentships plus the MRC. KMG was supported by the UK Medical Research Council (MC_UU_12011/4), the National Institute for Health Research (NIHR Senior Investigator [NF-SI-0515-10042], NIHR Southampton 1000DaysPlus Global Nutrition Research Group [17/63/154], and NIHR Southampton Biomedical Research Centre [IS-BRC-1215-20004]), British Heart Foundation (RG/15/17/3174) and the US National Institute on Aging of the National Institutes of Health (Award No. U24AG047867). KSJ was supported by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (ISBRC-1215-20014). The NIHR Cambridge Biomedical Research Centre is a partnership between Cambridge University Hospitals NHS Foundation Trust and the University of Cambridge, funded by the NIHR. The views expressed are those of the authors and not necessarily those of the NHS, the NIHR, or the Department of Health and Social Care. Experimental work performed by KSJ and FH at MRC. EWL was supported by Dr Ann Prentice (UK Medical Research Council U105960371). The SWS has been supported by grants from Medical Research Council (MRC) (4050502589 [MRC LEU]), Dunhill Medical Trust, British Heart Foundation, Food Standards Agency, National Institute for Health Research (NIHR) Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, NIHR Oxford Biomedical Research Centre, University of Oxford, and the European Union���s Seventh Framework Programme (FP7/2007-2013), project EarlyNutrition, under grant agreement 289346 and the European Union���s Horizon 2020 research and innovation program (LIFECYCLE, grant agreement no. 733206). EC has been supported by the Wellcome Trust (201268/Z/16/Z) and an NIHR Clinical Lectureship. Work leading to these results was supported by the BBSRC (HDHL-Biomarkers, BB/P028179/1), as part of the ALPHABET project, supported by an award made through the ERA-Net on Biomarkers for Nutrition and Health (ERA HDHL), Horizon 2020 grant agreement number 696295. The proteomic analyses (SDG and AM) were financially supported by the National Institutes of Health (R21AI122389) and the Beckman Institute at the California Institute of Technology. This project has received funding from the European Union���s Horizon 2020 research and innovation program under the Marie Sk��odowska-Curie grant agreement InvADeRS no. 841172 to JMF. The electron microscopy image in Figure 2 was produced with help of the Biomedical imaging unit, Faculty of Medicine, University of Southampton.

Published
2022
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