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425 results on '"Hyun, Insoo"'

1. Governing with public engagement: an anticipatory approach to human genome editing.

Author

Barlevy, Dorit, Juengst, Eric, Kahn, Jeffrey, Moreno, Jonathan, Lambert, Lauren, Charo, Alta, Chneiweiss, Hervé, Farooque, Mahmud, Guston, David, Hyun, Insoo, Knoepfler, Paul, Selin, Cynthia, Wilbanks, Rebecca, Zaghlula, Manar, and Scott, Christopher

Subjects
anticipatory governance, human genome editing, public engagement
Abstract

In response to calls for public engagement on human genome editing (HGE), which intensified after the 2018 He Jiankui scandal that resulted in the implantation of genetically modified embryos, we detail an anticipatory approach to the governance of HGE. By soliciting multidisciplinary experts input on the drivers and uncertainties of HGE development, we developed a set of plausible future scenarios to ascertain publics values-specifically, their hopes and concerns regarding the novel technology and its applications. In turn, we gathered a subset of multidisciplinary experts to propose governance recommendations for HGE that incorporate identified publics values. These recommendations include: (1) continued participatory public engagement; (2) international harmonization and transparency of multiple governance levers such as professional and scientific societies, funders, and regulators; and (3) development of a formal whistleblower framework.

Published
2024

9. ISSCR Guidelines for Stem Cell Research and Clinical Translation: The 2021 update.

Author

Lovell-Badge, Robin, Anthony, Eric, Barker, Roger A, Bubela, Tania, Brivanlou, Ali H, Carpenter, Melissa, Charo, R Alta, Clark, Amander, Clayton, Ellen, Cong, Yali, Daley, George Q, Fu, Jianping, Fujita, Misao, Greenfield, Andy, Goldman, Steve A, Hill, Lori, Hyun, Insoo, Isasi, Rosario, Kahn, Jeffrey, Kato, Kazuto, Kim, Jin-Soo, Kimmelman, Jonathan, Knoblich, Jürgen A, Mathews, Debra, Montserrat, Nuria, Mosher, Jack, Munsie, Megan, Nakauchi, Hiromitsu, Naldini, Luigi, Naughton, Gail, Niakan, Kathy, Ogbogu, Ubaka, Pedersen, Roger, Rivron, Nicolas, Rooke, Heather, Rossant, Janet, Round, Jeff, Saitou, Mitinori, Sipp, Douglas, Steffann, Julie, Sugarman, Jeremy, Surani, Azim, Takahashi, Jun, Tang, Fuchou, Turner, Leigh, Zettler, Patricia J, and Zhai, Xiaomei

Subjects
Biochemistry and Cell Biology, Clinical Sciences
Abstract

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients. A summary of the key updates and issues is presented here.

Published
2021

12. How collaboration between bioethicists and neuroscientists can advance research

Author

Hyun, Insoo, Scharf-Deering, J. C., Sullivan, Sarah, Aach, John Dennis, Arlotta, Paola, Baum, Matthew L., Church, George M., Goldenberg, Aaron, Greely, Henry T., Khoshakhlagh, Parastoo, Kohman, Richie E., Lopes, Melissa, Lowenthal, Caroline, Lu, Aric, Ng, Alex H. M., Pasca, Sergiu P., Paulsen, Bruna, Pigoni, Martina, Scott, Christopher T., Silbersweig, David A., Skylar-Scott, Mark A., Truog, Robert D., and Lunshof, Jeantine E.

Published
2022
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14. Dynamic models of human development and concepts of the individual.

Author

Hyun, Insoo

Subjects
*DYNAMIC models, *INDIVIDUAL development, *STEM cells, *HUMAN beings, *ANIMAL navigation
Abstract

Stem cells can be coaxed to self-organize into dynamic models of human development and early embryo formation. Despite their scientific promise, might widespread use of these technologies alter people's beliefs about what it means to be a human individual? Attention to some important philosophical distinctions may help navigate our thinking. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Setting Global Standards for Stem Cell Research and Clinical Translation: The 2016 ISSCR Guidelines.

Author

Daley, George Q, Hyun, Insoo, Apperley, Jane F, Barker, Roger A, Benvenisty, Nissim, Bredenoord, Annelien L, Breuer, Christopher K, Caulfield, Timothy, Cedars, Marcelle I, Frey-Vasconcells, Joyce, Heslop, Helen E, Jin, Ying, Lee, Richard T, McCabe, Christopher, Munsie, Megan, Murry, Charles E, Piantadosi, Steven, Rao, Mahendra, Rooke, Heather M, Sipp, Douglas, Studer, Lorenz, Sugarman, Jeremy, Takahashi, Masayo, Zimmerman, Mark, and Kimmelman, Jonathan

Subjects
Stem Cells, Humans, Informed Consent, Societies, Scientific, Clinical Trials as Topic, Stem Cell Research, Translational Medical Research, EMRO, clinical translation, clinical trials, communication, embryo research, guidelines, stem cells
Abstract

The International Society for Stem Cell Research (ISSCR) presents its 2016 Guidelines for Stem Cell Research and Clinical Translation (ISSCR, 2016). The 2016 guidelines reflect the revision and extension of two past sets of guidelines (ISSCR, 2006; ISSCR, 2008) to address new and emerging areas of stem cell discovery and application and evolving ethical, social, and policy challenges. These guidelines provide an integrated set of principles and best practices to drive progress in basic, translational, and clinical research. The guidelines demand rigor, oversight, and transparency in all aspects of practice, providing confidence to practitioners and public alike that stem cell science can proceed efficiently and remain responsive to public and patient interests. Here, we highlight key elements and recommendations in the guidelines and summarize the recommendations and deliberations behind them.

Published
2016

22. Debate ethics of embryo models from stem cells

Author

Rivron, Nicolas, Pera, Martin, Rossant, Janet, Martinez Arias, Alfonso, Zernicka-Goetz, Magdalena, Fu, Jianping, van den Brink, Susanne, Bredenoord, Annelien, Dondorp, Wybo, de Wert, Guido, Hyun, Insoo, Munsie, Megan, and Isasi, Rosario

Published
2018
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26. Clarifying the Ethics and Oversight of Chimeric Research

Author

Johnston, Josephine, primary, Hyun, Insoo, additional, Neuhaus, Carolyn P., additional, Maschke, Karen J., additional, Marshall, Patricia, additional, Craig, Kaitlynn P., additional, Matthews, Margaret M., additional, Drolet, Kara, additional, Greely, Henry T., additional, Hill, Lori R., additional, Hinterberger, Amy, additional, Hurley, Elisa A., additional, Kesterson, Robert, additional, Kimmelman, Jonathan, additional, King, Nancy M. P., additional, Lopes, Melissa J., additional, O'Rourke, P. Pearl, additional, Parent, Brendan, additional, Peckman, Steven, additional, Piotrowska, Monika, additional, Schwarz, May, additional, Sebo, Jeff, additional, Stodgell, Chris, additional, Streiffer, Robert, additional, and Wilkerson, Amy, additional

Published
2022
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29. Cell-based therapeutic strategies for multiple sclerosis

Author

Scolding, Neil J, Pasquini, Marcelo, Reingold, Stephen C, Cohen, Jeffrey A, Atkins, Harold, Banwell, Brenda, Bar-Or, Amit, Bebo, Bruce, Bowen, James, Burt, Richard, Calabresi, Peter, Cohen, Jeffrey, Comi, Giancarlo, Connick, Peter, Cross, Anne, Cutter, Gary, Derfuss, Tobias, Ffrench-Constant, Charles, Freedman, Mark, Galipeau, Jacques, Goldman, Myla, Goldman, Steven, Goodman, Andrew, Green, Ari, Griffith, Linda, Hartung, Hans-Peter, Hemmer, Bernhard, Hyun, Insoo, Iacobaeus, Ellen, Inglese, Matilde, Jubelt, Burk, Karussis, Dimitrios, Küry, Patrick, Landsman, Douglas, Laule, Cornelia, Liblau, Roland, Mancardi, Giovanni, Ann Marrie, Ruth, Miller, Aaron, Miller, Robert, Miller, David, Mowry, Ellen, Muraro, Paolo, Nash, Richard, Ontaneda, Daniel, Pasquini, Marcelo, Pelletier, Daniel, Peruzzotti-Jametti, Luca, Pluchino, Stefano, Racke, Michael, Reingold, Stephen, Rice, Claire, Ringdén, Olle, Rovira, Alex, Saccardi, Riccardo, Sadiq, Saud, Sarantopoulos, Stefanie, Savitz, Sean, Scolding, Neil, Soelberg Sorensen, Per, Pia Sormani, Maria, Stuve, Olaf, Tesar, Paul, Thompson, Alan, Trojano, Maria, Uccelli, Antonio, Uitdehaag, Bernard, Utz, Ursula, Vukusic, Sandra, Waubant, Emmanuelle, and Wilkins, Alastair

Published
2017
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30. Minibrains: What's in a Name? The Reality of Organoids

Author

Lopes, Melissa, Kohman, Richie E., Lunshof, Jeantine E., Paulsen, Bruna, Pigoni, Martina, White, Sasha, Aach, John, and Hyun, Insoo

Subjects
Brain -- Models -- Physiological aspects, Tissue culture -- Methods, Science and technology
Abstract

Brain organoids have emerged in recent years as a powerful new tool for neuroscience research. Unfortunately, the promise of this tool has been muddied by misplaced fear and hype, born [...]

Published
2021

32. The need for a standard for informed consent for collection of human fetal material

Author

Barker, Roger A., primary, Boer, Gerard J., additional, Cattaneo, Elena, additional, Charo, R. Alta, additional, Chuva de Sousa Lopes, Susana M., additional, Cong, Yali, additional, Fujita, Misao, additional, Goldman, Steven, additional, Hermerén, Göran, additional, Hyun, Insoo, additional, Lisgo, Steven, additional, Rosser, Anne E., additional, Anthony, Eric, additional, and Lindvall, Olle, additional

Published
2022
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33. The need for a standard for informed consent for collection of human fetal material

Author

Barker, Roger A, Boer, Gerard J, Cattaneo, Elena, Charo, R Alta, Chuva de Sousa Lopes, Susana M, Cong, Yali, Fujita, Misao, Goldman, Steven, Hermerén, Göran, Hyun, Insoo, Lisgo, Steven, Rosser, Anne E, Anthony, Eric, Lindvall, Olle, Barker, Roger A, Boer, Gerard J, Cattaneo, Elena, Charo, R Alta, Chuva de Sousa Lopes, Susana M, Cong, Yali, Fujita, Misao, Goldman, Steven, Hermerén, Göran, Hyun, Insoo, Lisgo, Steven, Rosser, Anne E, Anthony, Eric, and Lindvall, Olle

Abstract

The ISSCR has developed the Informed Consent Standards for Human Fetal Tissue Donation and Research to promote uniformity and transparency in tissue donation and collection. This standard is designed to assist those working with and overseeing the regulation of such tissue and reassure the wider community and public.

Published
2022

38. List of Contributors

Author

Adair, Jennifer E., primary, Ahmed, Jahangir, additional, Alusi, Ghassan, additional, Amit, Doron, additional, Antonia, Scott J., additional, Auci, Dominick L., additional, August, David A., additional, Balvers, Rutger K., additional, Baranyi, Lajos, additional, Beard, Brian C., additional, Brennig, Sebastian, additional, Broussard, Elizabeth K., additional, Bryson, Paul D., additional, Byrnes, Andrew P., additional, Cecil, Denise L., additional, Chan, Tim, additional, Comins, Charlie, additional, de Vries, Christiaan R., additional, DiPaola, Robert S., additional, Dirven, Clemens M.F., additional, Disis, Mary L., additional, Dropulic, Boro, additional, Embree, Heather, additional, Epperly, Michael W., additional, Fueyo, Juan, additional, Fujiwara, Toshiyoshi, additional, Fung, Hua, additional, Gabriel, Emmanuel, additional, Ganapath, Vidya, additional, Gerson, Stanton L., additional, Gill, Steven, additional, Gilon, Michal, additional, Goldufsky, Joe, additional, Gomez-Manzano, Candelaria, additional, Grandis, Jennifer Rubin, additional, Greenberger, Joel S., additional, Greiner, John W., additional, Gujrati, Maneesh, additional, Gulley, James L., additional, Hajitou, Amin, additional, Harrington, Kevin J., additional, Hatefi, Arash, additional, Heller, Loree C., additional, Heller, Richard, additional, Hemminki, Akseli, additional, Hemminki, Otto, additional, Herberman, Ronald B., additional, Herendeen, Daniel, additional, Hochberg, Abraham, additional, Hodge, James W., additional, Holt, Gregory E., additional, Huang, Ying, additional, Hyun, Insoo, additional, Jiang, Hong, additional, Kagawa, Shunsuke, additional, Karjoo, Zahra, additional, Kaufman, Howard, additional, Ke, Chien-Chih, additional, Kiem, Hans-Peter, additional, Kimmelman, Jonathan, additional, Klein, Sarah R., additional, Kuroda, Shinji, additional, Kwon, Seong Young, additional, Lachmann, Nico, additional, Lage, Hermann, additional, Lamfers, Martine L.M., additional, Lattime, Edmund C., additional, Lemoine, Nicholas R., additional, Lewis, Jonathan, additional, Liao, John B., additional, Libutti, Steven K., additional, Lin, Yuan, additional, Liu, Ren-Shyan, additional, Lu, Zheng-Rong, additional, Madan, Ravi A., additional, Matouk, Imad, additional, Melcher, Alan, additional, Miller, Andrew D., additional, Min, Jung-Joon, additional, Moritz, Thomas, additional, Mulé, James J., additional, Natsume, Atsushi, additional, Nianiaris, Nastasia, additional, Nishimura, Michael I., additional, Palena, Claudia, additional, Pandha, Hardev, additional, Pastoriza, Jessica, additional, Pinder-Schenck, Mary C., additional, Piya, Sujan, additional, Poplin, Elizabeth, additional, Puskas, John A., additional, Quinn, Thomas, additional, Rao, Ankit, additional, Reese, Jane S., additional, Relph, Kate, additional, Rojas, Juan J., additional, Saenger, Yvonne, additional, Schlom, Jeffrey, additional, Shannon, Kevin, additional, Shirley, Shawna A., additional, Simpson, Guy R., additional, Sivendran, Shanthi, additional, Slepushkin, Vladimir, additional, Songsivilai, Sirirurg, additional, Steven, Neil, additional, Thomas, Sufi Mary, additional, Thorne, Steve H., additional, Tsang, Kwong-Yok, additional, Tsujiuchi, Takashi, additional, Wakabayashi, Toshihiko, additional, Wang, Pin, additional, Wang, Xinxin, additional, Wang, Yaohe, additional, Weiss, Robert E., additional, White, Edward, additional, Yagawa, Yohsuke, additional, Yata, Teerapong, additional, Yuan, Ming, additional, and Yuan, Ziqiang, additional

Published
2014
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40. ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts

Author

Hyun, Insoo, primary, Clayton, Ellen Wright, additional, Cong, Yali, additional, Fujita, Misao, additional, Goldman, Steven A., additional, Hill, Lori R., additional, Monserrat, Nuria, additional, Nakauchi, Hiromitsu, additional, Pedersen, Roger A., additional, Rooke, Heather M., additional, Takahashi, Jun, additional, and Knoblich, Jürgen A., additional

Published
2021
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41. ISSCR Guidelines for Stem Cell Research and Clinical Translation:The 2021 update

Author

Lovell-Badge, Robin, Anthony, Eric, Barker, Roger A., Bubela, Tania, Brivanlou, Ali H., Carpenter, Melissa, Charo, R. Alta, Clark, Amander, Clayton, Ellen, Cong, Yali, Daley, George Q., Fu, Jianping, Fujita, Misao, Greenfield, Andy, Goldman, Steve A., Hill, Lori, Hyun, Insoo, Isasi, Rosario, Kahn, Jeffrey, Kato, Kazuto, Kim, Jin Soo, Kimmelman, Jonathan, Knoblich, Jürgen A., Mathews, Debra, Montserrat, Nuria, Mosher, Jack, Munsie, Megan, Nakauchi, Hiromitsu, Naldini, Luigi, Naughton, Gail, Niakan, Kathy, Ogbogu, Ubaka, Pedersen, Roger, Rivron, Nicolas, Rooke, Heather, Rossant, Janet, Round, Jeff, Saitou, Mitinori, Sipp, Douglas, Steffann, Julie, Sugarman, Jeremy, Surani, Azim, Takahashi, Jun, Tang, Fuchou, Turner, Leigh, Zettler, Patricia J., Zhai, Xiaomei, Lovell-Badge, Robin, Anthony, Eric, Barker, Roger A., Bubela, Tania, Brivanlou, Ali H., Carpenter, Melissa, Charo, R. Alta, Clark, Amander, Clayton, Ellen, Cong, Yali, Daley, George Q., Fu, Jianping, Fujita, Misao, Greenfield, Andy, Goldman, Steve A., Hill, Lori, Hyun, Insoo, Isasi, Rosario, Kahn, Jeffrey, Kato, Kazuto, Kim, Jin Soo, Kimmelman, Jonathan, Knoblich, Jürgen A., Mathews, Debra, Montserrat, Nuria, Mosher, Jack, Munsie, Megan, Nakauchi, Hiromitsu, Naldini, Luigi, Naughton, Gail, Niakan, Kathy, Ogbogu, Ubaka, Pedersen, Roger, Rivron, Nicolas, Rooke, Heather, Rossant, Janet, Round, Jeff, Saitou, Mitinori, Sipp, Douglas, Steffann, Julie, Sugarman, Jeremy, Surani, Azim, Takahashi, Jun, Tang, Fuchou, Turner, Leigh, Zettler, Patricia J., and Zhai, Xiaomei

Abstract

The International Society for Stem Cell Research has updated its Guidelines for Stem Cell Research and Clinical Translation in order to address advances in stem cell science and other relevant fields, together with the associated ethical, social, and policy issues that have arisen since the last update in 2016. While growing to encompass the evolving science, clinical applications of stem cells, and the increasingly complex implications of stem cell research for society, the basic principles underlying the Guidelines remain unchanged, and they will continue to serve as the standard for the field and as a resource for scientists, regulators, funders, physicians, and members of the public, including patients. A summary of the key updates and issues is presented here.

Published
2021

42. ISSCR guidelines for the transfer of human pluripotent stem cells and their direct derivatives into animal hosts

Author

Hyun, Insoo, Clayton, Ellen Wright, Cong, Yali, Fujita, Misao, Goldman, Steven A., Hill, Lori R., Monserrat, Nuria, Nakauchi, Hiromitsu, Pedersen, Roger A., Rooke, Heather M., Takahashi, Jun, Knoblich, Jürgen A., Hyun, Insoo, Clayton, Ellen Wright, Cong, Yali, Fujita, Misao, Goldman, Steven A., Hill, Lori R., Monserrat, Nuria, Nakauchi, Hiromitsu, Pedersen, Roger A., Rooke, Heather M., Takahashi, Jun, and Knoblich, Jürgen A.

Abstract

The newly revised 2021 ISSCR Guidelines for Stem Cell Research and Clinical Translation includes scientific and ethical guidance for the transfer of human pluripotent stem cells and their direct derivatives into animal models. In this white paper, the ISSCR subcommittee that drafted these guidelines for research involving the use of nonhuman embryos and postnatal animals explains and summarizes their recommendations.

Published
2021

43. The bioethics of stem cell research and therapy

Author

Hyun, Insoo

Subjects
Medical ethics -- Research -- Methods -- Forecasts and trends, Stem cell research -- Forecasts and trends -- Ethical aspects -- Research -- Methods, Stem cells -- Transplantation, Market trend/market analysis, Health care industry
Abstract

Discussion of the bioethics of human stem cell research has transitioned from controversies over the source of human embryonic stem cells to concerns about the ethical use of stem cells in basic and clinical research. Key areas in this evolving ethical discourse include the derivation and use of other human embryonic stem cell-like stem cells that have the capacity to differentiate into all types of human tissue and the use of all types of stem cells in clinical research. Each of these issues is discussed as I summarize the past, present, and future bioethical issues in stem cell research., The main bioethical issues associated with human stem cells involve their derivation and use for research. Although there are interesting ethical issues surrounding the collection and use of somatic (adult) [...]

Published
2010
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45. The Stem Cell Research Environment: A Patchwork of Patchworks

Author

Caulfield, Timothy, Zarzeczny, Amy, McCormick, Jennifer, Bubela, Tania, Critchley, Christine, Einsiedel, Edna, Galipeau, Jacques, Harmon, Shawn, Huynh, Michael, Hyun, Insoo, Illes, Judy, Isasi, Rosario, Joly, Yann, Laurie, Graeme, Lomax, Geoff, Longstaff, Holly, McDonald, Michael, Murdoch, Charles, Ogbogu, Ubaka, Owen-Smith, Jason, Pattinson, Shaun, Premji, Shainur, von Tigerstrom, Barbara, and Winickoff, David E.

Published
2009
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47. Stem Cell Research Ethics: Consensus Statement on Emerging Issues

Author

Caulfield, Timothy, Ogbogu, Ubaka, Nelson, Erin, Einsiedel, Edna, Knoppers, Bartha, McDonald, Michael, Brunger, Fern, Downey, Robin, Fernando, Kanchana, Galipeau, Jacques, Geransar, Rose, Grenier, Glenn, Hyun, Insoo, Isasi, Rosario, Kardel, Melanie, Knowles, Lori, Kucic, Terrence, Lotjonen, Salla, Lyall, Drew, Magnus, David, Mathews, Debra J.H., Nisbet, Matthew, Nisker, Jeffrey, Pare, Guillaume, Pattinson, Shaun, Pullman, Daryl, Rudnicki, Michael, Williams-Jones, Bryn, and Zimmerman, Susan

Published
2007
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48. Rethinking organoid technology through bioengineering

Author

Garreta, Elena, primary, Kamm, Roger D., additional, Chuva de Sousa Lopes, Susana M., additional, Lancaster, Madeline A., additional, Weiss, Ron, additional, Trepat, Xavier, additional, Hyun, Insoo, additional, and Montserrat, Nuria, additional

Published
2020
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50. Waiver of informed consent, cultural sensitivity, and the problem of unjust families and traditions

Author

Hyun, Insoo

Subjects
Physical diagnosis -- Ethical aspects -- Social aspects -- Analysis, Patients -- Care and treatment -- Demographic aspects -- Ethical aspects, Medical research -- Analysis -- Social aspects, Medicine, Experimental -- Analysis -- Social aspects, Medical professions -- Ethical aspects -- Analysis -- Social aspects, Periodic health examinations -- Ethical aspects -- Social aspects -- Analysis, Physician and patient -- Demographic aspects -- Social aspects -- Analysis, Multiculturalism -- Social aspects -- Analysis, Decision-making -- Analysis -- Social aspects, Physicians -- Ethical aspects, Authors -- Ethical aspects, Biological sciences, Health
Abstract

Caring for patients from different cultures presents a variety of challenges. One of the most complex centers on a worry that the formal requirements for obtaining informed consent may impose [...]

Published
2002

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