333 results on '"Isacsson P"'
Search Results
2. Quantitative predictions of the thermal conductivity in transition metal dichalcogenides: The impact of point defects in MoS$_2$ and WS$_2$ monolayers
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Mahendran, Srinivisan, Carrete, Jesús, Isacsson, Andreas, Madsen, Georg K. H., and Erhart, Paul
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Condensed Matter - Materials Science ,Physics - Computational Physics - Abstract
Transition metal dichalcogenides are investigated for various applications at the nanoscale thanks to their unique combination of properties and dimensionality. For many of the anticipated applications, heat conduction plays an important role. At the same time, these materials often contain relatively large amounts of point defects. Here, we provide a systematic analysis of the impact of intrinsic and selected extrinsic defects on the lattice thermal conductivity of MoS$_2$ and WS$_2$ monolayers. We combine Boltzmann transport theory and the Green's function-based T-matrix approach for the calculation of scattering rates. The force constants for the defect configurations are obtained from density functional theory calculations via a regression approach, which allows us to sample a rather large number of defects at a moderate computational cost and to systematically enforce both the translational and rotational acoustic sum rules. The calculated lattice thermal conductivity is in quantitative agreement with experimental data for heat transport and defect concentrations for both MoS$_2$ and WS$_2$. Crucially, this demonstrates that the strong deviation from a 1/T-temperature dependence of the lattice thermal conductivity observed experimentally, can be fully explained by the presence of point defects. We furthermore predict the scattering strengths of the intrinsic defects to decrease in the sequence $V_{Mo}\approx V_{2S}^=>V_{2S}^\perp>V_S>S_{ad}$ in both materials, while the scattering rates for the extrinsic (adatom) defects decrease with increasing mass such that Li$_{ad}$>Na$_{ad}$>K$_{ad}$. Compared to earlier work, we find that both intrinsic and extrinsic adatoms are relatively weak scatterers. We attribute this difference to the treatment of the translational and rotational acoustic sum rules, which if not enforced can lead to spurious contributions in the zero-frequency limit., Comment: 8 pages, 4 figures
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- 2023
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3. Methodological choices and clinical usefulness for machine learning predictions of outcome in Internet-based cognitive behavioural therapy
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Nils Hentati Isacsson, Fehmi Ben Abdesslem, Erik Forsell, Magnus Boman, and Viktor Kaldo
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Medicine - Abstract
Abstract Background While psychological treatments are effective, a substantial portion of patients do not benefit enough. Early identification of those may allow for adaptive treatment strategies and improved outcomes. We aimed to evaluate the clinical usefulness of machine-learning (ML) models predicting outcomes in Internet-based Cognitive Behavioural Therapy, to compare ML-related methodological choices, and guide future use of these. Methods Eighty main models were compared. Baseline variables, weekly symptoms, and treatment activity were used to predict treatment outcomes in a dataset of 6695 patients from regular care. Results We show that the best models use handpicked predictors and impute missing data. No ML algorithm shows clear superiority. They have a mean balanced accuracy of 78.1% at treatment week four, closely matched by regression (77.8%). Conclusions ML surpasses the benchmark for clinical usefulness (67%). Advanced and simple models perform equally, indicating a need for more data or smarter methodological designs to confirm advantages of ML.
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- 2024
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4. Extracting the Dispersion of Periodic Lossless LC Circuits Using White Noise
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Shiri, Daryoush and Isacsson, Andreas
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science ,Electrical Engineering and Systems Science - Signal Processing - Abstract
The spectral energy density (SED) method is used to obtain the phonon dispersion of materials in molecular dynamics codes, e.g., LAMMPS. We show how the electric analog of the SED method can be done using commercial circuit simulators to find the dispersion of periodic lossless LC circuits. The purpose of this article is (a) to demonstrate how SED proves useful, should the analytic methods of calculating dispersion of a circuit render difficult e.g., due to nonlinearity or having large number of elements in each unit-cell, and (b) to show how the concepts like Brillouin zone (BZ), dispersion (or band structure), zone folding, gap formation, and avoided crossing can be taught to students of electrical engineering by highlighting the analogies between phonons and periodic circuits. This analogy also suggests that thermal devices, e.g., heat rectifiers can be simulated and understood using commercial circuit simulators., Comment: 9 pages, 10 Figures
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- 2022
5. Aristocrats and Refined Peasants: The Concept of Aristocracy in Swedish Historiography
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Alexander Isacsson
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aristocracy ,anti-aristocratic prejudice ,Sweden ,historiography ,peasant elites ,History (General) ,D1-2009 - Abstract
This article investigates the evolution of aristocracy as a concept in Swedish historiography from the early nineteenth century to the present. In the political climate of the early 1800s, aristocracy became an increasingly contested concept, as reflected in ordinary language and the writing of national histories. A scholarly debate over anti-aristocratic prejudice between the historians Anders Fryxell and Erik Gustaf Geijer in the 1840s illustrates contemporary concerns to define the Swedish aristocracy and its relation to the nation. The debate gave rise to a persistent yet adaptable dualistic view of history, enduring well into the twentieth century. Historians portrayed monarchs, aristocrats, nobles, and peasants in a dualistic manner, dividing social groups into two oppositional forces. By emphasising the agency of freeholding peasants, notions of a Swedish Sonderweg were reinforced, facilitating the conceptualisation of peasant aristocrats. In tracing this historical trajectory, the article demonstrates how the meaning of aristocracy has evolved in response to scholarly objectives and historiographical trends.
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- 2024
6. Het diskussion och utmanande tystnad: Att lära sig att leda samtal om identitet, sexualitet och relationer
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Alexander Isacsson, James Lancaster, and Henric Bagerius
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rollspel ,muntlighet ,identitet ,sexualitet ,relationer ,Education (General) ,L7-991 - Abstract
Hösten 2021 infördes ett nytt examensmål för lärarutbildningarna rörande lärarstudenternas förmåga att ”kommunicera och reflektera kring frågor som rör identitet, sexualitet och relationer”. För att våra studenter ska kunna uppfylla detta mål har vi inom historieämnet på ämneslärarutbildningen vid Örebro universitet infört ett obligatoriskt moment i form av en muntlig rollspelsövning. I denna text diskuterar vi möjligheterna att stärka studenters kompetens i att genomföra historiska samtal om ämnen som kan upplevas som känsliga, fördjupa deras förmåga att leda pedagogiska samtal och utveckla deras kommunikativa utsträckning integrera muntliga övningar inom högre utbildning. ENGLISH ABSTRACT Heated discussion and challenging silence: Learning to lead conversations about identity, sexuality and relationships In 2021, a new requirement for obtaining a teacher’s certificate was added to the Swedish Higher Education Ordinance. Students must now demonstrate an ability to “communicate and reflect on issues regarding identity, sexuality and relationships”. In a history course within the teacher education programme at Örebro University, we have developed an obligatory roleplay exercise focused on verbal communication to meet this requirement. Here, we discuss how the role-play exercise can develop students’ communicative abilities and strengthen their competencies in leading group discussions on issues potentially perceived as sensitive. Like our students, we recognize the value of incorporating verbal, communicative exercises into the curriculum to a higher degree.
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- 2024
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7. Dataset size versus homogeneity: A machine learning study on pooling intervention data in e-mental health dropout predictions
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Kirsten Zantvoort, Nils Hentati Isacsson, Burkhardt Funk, and Viktor Kaldo
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Computer applications to medicine. Medical informatics ,R858-859.7 - Abstract
Objective This study proposes a way of increasing dataset sizes for machine learning tasks in Internet-based Cognitive Behavioral Therapy through pooling interventions. To this end, it (1) examines similarities in user behavior and symptom data among online interventions for patients with depression, social anxiety, and panic disorder and (2) explores whether these similarities suffice to allow for pooling the data together, resulting in more training data when prediction intervention dropout. Methods A total of 6418 routine care patients from the Internet Psychiatry in Stockholm are analyzed using (1) clustering and (2) dropout prediction models. For the latter, prediction models trained on each individual intervention's data are compared to those trained on all three interventions pooled into one dataset. To investigate if results vary with dataset size, the prediction is repeated using small and medium dataset sizes. Results The clustering analysis identified three distinct groups that are almost equally spread across interventions and are instead characterized by different activity levels. In eight out of nine settings investigated, pooling the data improves prediction results compared to models trained on a single intervention dataset. It is further confirmed that models trained on small datasets are more likely to overestimate prediction results. Conclusion The study reveals similar patterns of patients with depression, social anxiety, and panic disorder regarding online activity and intervention dropout. As such, this work offers pooling different interventions’ data as a possible approach to counter the problem of small dataset sizes in psychological research.
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- 2024
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8. Trust at Work -- Described by Young Professionals in the Early Stages of Their Careers
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Raatikainen, Eija, Savolainen, Taina, Järvensivu, Anu, Isacsson, Annica, Simola-Alha, Nina, and Heinilä, Henna
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Purpose: This case study explores trust at work, described by young professionals in the early stages of their careers. In this article, trust is approached as the study participants' experiences of interpersonal trust. More specifically, it refers to relationships between colleagues, among individuals or at group level (Ma et al., 2019). Supervisors or managers did not take part in this study. The research question was "What do young professionals tell about trust and its importance at work?" Design/methodology/approach: The empirical study consists of qualitative data, focus group (5) interviews (n = 20) of young professionals who are in the early stages of their careers (1-3 years after graduation). The study is contextualized in Finland, in Helsinki metropolitan area, in three social and healthcare workplaces and two information technology (IT) organizations. Both public and private sectors are represented. The data were analysed by theory-based content analysis. Findings: According to the study results, descriptions of trust and its importance at work can be placed in three main categories. First, trust is an important element in improving young professionals' adaptation into the working community. Second, trust strengthens young professionals' professionalism and professional development at work. Third, trust at work highlights ethical issues and their significance in workplace relationships. Practical implications and limitations are also discussed. Research limitations/implications: Due to the nature of this study, the research results should be viewed critically. The results can be seen as one suggestion to structure and increase understanding of trust in working life, from the perspective of young professionals in the early stages of their careers. As all research, the studies included in this review had several limitations that need to be taken into account. First, one of them is the size of the data, also in this study. Second, although literature has been searched carefully, there is always a chance of better literature existing for discussion on trust at work from young professionals' points of view, even though there is not a lot available on this specific topic. Nonetheless, literature of this study includes the most relevant classics of trust research. Third, the method has its own limits because it is based on focus group interviews, not interviews of individuals. On the other hand, it offered time for the team to reflect on trust in their own team. Still, this study offers one option for discussion of trust in work relationships. Additionally, it was noteworthy that the subjects were at the beginning of their careers, joining a new working community. They were in the early stages of building a professional identity, seeking confirmation of their skills and position in the working community. Thus, we recognize that this may have contributed to the collection of research data, which was a focus group interview. Few participants in the interview wanted to strongly point out the factors related to distrust, even if they had appeared at work. The authors recognize that exploring trust requires trust and acknowledge it. Data have been collected before the COVID-19 pandemic (see, e.g. van Zoonen et al., 2021). Practical implications: This study implies that trust at work should focus on discussing young professionals' thoughts, expectations, feelings and experiences of trust at work as part of transitioning from graduation into working life or in early stages of their careers. Trust should not only be discussed in dyadic discussions between young professionals and supervisors but also as part of team discussions. The authors' suggestion is that trust should be in the core of team discussions, not just as part of teams' social and emotional dimensions of their functionality and capacity. Courage and skills to take part in such discussions is needed from all parties. Especially leaders have to have the ability to create a trusting environment to talk about trust. In particular, the importance of peers in trust and their importance at work should be taken into account. By understanding young professionals' point of view, we can prevent job changes or dissatisfaction at work too. The purpose of this study was to contribute to this line of research on trust at work. The trust resource contributes to and promotes the realization of participation in working life. Social implications: The trust resource contributes to and promotes the realization of participation in working life. Leaders and coworkers can learn about trust as a phenomenon, while developing more emotionally sustainable working environments for young professionals. Trust should be seen as a skill or competence to improve various positive functional dimensions at work. Originality/value: The results demonstrate that it is crucial to ensure emotional sustainability at work, and a positive feeling of belonging at work supports young professionals by developing a trusting work environment. It strengthens their engagement in a new work.
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- 2023
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9. Primary Care Behavioral Health in Sweden – a protocol of a cluster randomized trial evaluating outcomes related to implementation, organization, and patients (KAIROS)
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Farnsworth von Cederwald, Anneli, Lilja, Josefine L., Hentati Isacsson, Nils, and Kaldo, Viktor
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- 2023
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10. Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?
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Söderström, Helena, Walfridsson, Angelica, Martinsson, Ulla, Isacsson, Ulf, Brocki, Karin, Kleberg, Johan Lundin, and Ljungman, Gustaf
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- 2023
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11. Clinical, patient-reported, radiographic and magnetic resonance imaging findings 11 years after acute posterior cruciate ligament injury treated non-surgically
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Brown, Jamie S, Mogianos, Krister, Roemer, Frank W, Isacsson, Anders, Kumm, Jaanika, Frobell, Richard, Olsson, Ola, and Englund, Martin
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- 2023
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12. Primary Care Behavioral Health in Sweden – a protocol of a cluster randomized trial evaluating outcomes related to implementation, organization, and patients (KAIROS)
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Anneli Farnsworth von Cederwald, Josefine L. Lilja, Nils Hentati Isacsson, and Viktor Kaldo
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PCBH ,Primary care behavioral health ,Primary care ,Integrated care ,Behavioral health ,Mental health ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Providing comprehensive and continuous care for patients whose conditions have mental or behavioral components is a central challenge in primary care and an important part of improving universal health coverage. There is a great need for high and routine availability of psychological interventions, but traditional methods for delivering psychotherapy often result in low reach and long wait times. Primary Care Behavioral Health (PCBH) is a method for organizing primary care in which behavioral health staff provide brief, flexible interventions to a large part of the population in active collaboration with other providers. While PCBH holds promise in addressing important challenges, it has not yet been thoroughly evaluated. Methods This cluster randomized trial will assess 17 primary care centers (PCCs) that are starting a PCBH implementation process. The PCCs will be divided into two groups, with one starting immediate implementation and the other acting as a control, implementing six months later. The purpose of the study is to strengthen the evidence base for PCBH regarding implementation-, organization-, and patient-level outcomes, taking into consideration that there is a partially dependent relationship between the three levels. Patient outcomes (such as increased daily functioning and reduction of symptoms) may be dependent on organizational changes (such as availability of treatment, waiting times and interprofessional teamwork), which in turn requires change in implementation outcomes (most notably, model fidelity). In addition to the main analysis, five secondary analyses will compare groups based on different combinations of randomization and time periods, specifically before and after each center achieves sufficient PCBH fidelity. Discussion A randomized comparison of PCBH and traditional primary care has, to our knowledge, not been made before. While the naturalistic setting and the intricacies of implementation pose certain challenges, we have designed this study in an effort to evaluate the causal effects of PCBH despite these complex aspects. The results of this project will be helpful in guiding decisions on how to organize the delivery of behavioral interventions and psychological treatment within the context of primary care in Sweden and elsewhere. Trial registration ClinicalTrials.gov: NCT05335382. Retrospectively registered on March 13th, 2022.
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- 2023
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13. Neurocognition and mean radiotherapy dose to vulnerable brain structures: new organs at risk?
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Helena Söderström, Angelica Walfridsson, Ulla Martinsson, Ulf Isacsson, Karin Brocki, Johan Lundin Kleberg, and Gustaf Ljungman
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Pediatric brain tumor ,Neurocognition ,Radiotherapy doses ,Organs at risk ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Children with brain tumors are at high risk of neurocognitive decline after radiotherapy (RT). However, there is a lack of studies on how RT doses to organs at risk (OARs) impacts neurocognition. The aim of this study was to examine dose-risk relationships for mean RT dose to different brain structures important for neurocognitive networks. We explored previously established OARs and potentially new OARs. Methods A sample of 44 pediatric brain tumor survivors who had received proton and/or photon RT were included. Correlations between mean RT doses to OARs and IQ were analyzed. Previously established OARs were cochleae, optic chiasm, optic nerve, pituitary gland, hypothalamus, hippocampus and pons. Potential new OARs for RT-induced neurocognitive decline were cerebellum, vermis and thalamus. Results Mean RT dose to different OARs correlated with several IQ subtests. Higher mean RT dose to cochleae, optic nerve, cerebellum, vermis and pons was correlated with lower performance on particularly full-scale IQ (FIQ), Perceptual Reasoning (PRI), Working Memory (WMI) and Processing Speed Index (PSI). Higher mean RT dose to hippocampus correlated with lower performance on processing speed and working memory. For those receiving whole brain RT (WBRT), higher mean RT dose to the pituitary gland correlated with lower performance on working memory. Conclusion A high dose-risk correlation was found between IQ subtests and mean RT dose in established and potential new OARs. Thus, in the lack of validated dose constraints for vulnerable brain structures, a parsimonious approach in RT planning should be considered to preserve neurocognitive networks.
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- 2023
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14. Fast simulation of bosonic qubits via Gaussian functions in phase space
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Bourassa, J. Eli, Quesada, Nicolás, Tzitrin, Ilan, Száva, Antal, Isacsson, Theodor, Izaac, Josh, Sabapathy, Krishna Kumar, Dauphinais, Guillaume, and Dhand, Ish
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Quantum Physics - Abstract
Bosonic qubits are a promising route to building fault-tolerant quantum computers on a variety of physical platforms. Studying the performance of bosonic qubits under realistic gates and measurements is challenging with existing analytical and numerical tools. We present a novel formalism for simulating classes of states that can be represented as linear combinations of Gaussian functions in phase space. This formalism allows us to analyze and simulate a wide class of non-Gaussian states, transformations and measurements. We demonstrate how useful classes of bosonic qubits -- Gottesman-Kitaev-Preskill (GKP), cat, and Fock states -- can be simulated using this formalism, opening the door to investigating the behaviour of bosonic qubits under Gaussian channels and measurements, non-Gaussian transformations such as those achieved via gate teleportation, and important non-Gaussian measurements such as threshold and photon-number detection. Our formalism enables simulating these situations with levels of accuracy that are not feasible with existing methods. Finally, we use a method informed by our formalism to simulate circuits critical to the study of fault-tolerant quantum computing with bosonic qubits but beyond the reach of existing techniques. Specifically, we examine how finite-energy GKP states transform under realistic qubit phase gates; interface with a CV cluster state; and transform under non-Clifford T gate teleportation using magic states. We implement our simulation method as a part of the open-source Strawberry Fields Python library., Comment: Code available at: https://github.com/XanaduAI/strawberryfields. Documentation available at: https://strawberryfields.readthedocs.io/en/latest/. Tutorials available at: https://strawberryfields.ai/photonics/demonstrations.html
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- 2021
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15. Quantum circuits with many photons on a programmable nanophotonic chip
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Arrazola, J. M., Bergholm, V., Brádler, K., Bromley, T. R., Collins, M. J., Dhand, I., Fumagalli, A., Gerrits, T., Goussev, A., Helt, L. G., Hundal, J., Isacsson, T., Israel, R. B., Izaac, J., Jahangiri, S., Janik, R., Killoran, N., Kumar, S. P., Lavoie, J., Lita, A. E., Mahler, D. H., Menotti, M., Morrison, B., Nam, S. W., Neuhaus, L., Qi, H. Y., Quesada, N., Repingon, A., Sabapathy, K. K., Schuld, M., Su, D., Swinarton, J., Száva, A., Tan, K., Tan, P., Vaidya, V. D., Vernon, Z., Zabaneh, Z., and Zhang, Y.
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Quantum Physics - Abstract
Growing interest in quantum computing for practical applications has led to a surge in the availability of programmable machines for executing quantum algorithms. Present day photonic quantum computers have been limited either to non-deterministic operation, low photon numbers and rates, or fixed random gate sequences. Here we introduce a full-stack hardware-software system for executing many-photon quantum circuits using integrated nanophotonics: a programmable chip, operating at room temperature and interfaced with a fully automated control system. It enables remote users to execute quantum algorithms requiring up to eight modes of strongly squeezed vacuum initialized as two-mode squeezed states in single temporal modes, a fully general and programmable four-mode interferometer, and genuine photon number-resolving readout on all outputs. Multi-photon detection events with photon numbers and rates exceeding any previous quantum optical demonstration on a programmable device are made possible by strong squeezing and high sampling rates. We verify the non-classicality of the device output, and use the platform to carry out proof-of-principle demonstrations of three quantum algorithms: Gaussian boson sampling, molecular vibronic spectra, and graph similarity.
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- 2021
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16. Incidence and concomitant chondral injuries in a consecutive cohort of primary traumatic patellar dislocations examined with sub-acute MRI
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Isacsson, Anders, Olsson, Ola, Englund, Martin, and Frobell, Richard B.
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- 2023
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17. Clinical, patient-reported, radiographic and magnetic resonance imaging findings 11 years after acute posterior cruciate ligament injury treated non-surgically
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Jamie S Brown, Krister Mogianos, Frank W Roemer, Anders Isacsson, Jaanika Kumm, Richard Frobell, Ola Olsson, and Martin Englund
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Posterior cruciate ligament ,Non-surgical treatment ,Long-term outcome ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Abstract Background Long-term consequences of posterior cruciate ligament (PCL) injury such as persistent posterior tibial translation and risk of osteoarthritis development are unclear. Additionally, little data is available describing the natural history of structural morphology of the ruptured PCL. The purpose of the study was to determine the long-term outcome after non-operatively treated PCL injury. Methods Over 6-years, all acute knee injuries were documented by subacute MRI (median 8 days [5–15, 25th − 75th percentile] from injury to MRI). Twenty-six patients with acute PCL injury were identified of whom 18 (69%) participated in the long-term follow-up after 11 years. Follow-up included radiographic posterior tibial translation (RPTT) determined using the Puddu axial radiograph. weight-bearing knee radiographs, MRI and KOOS (Knee injury and Osteoarthritis Outcome Score). Results On subacute MRI, 11 knees displayed total and 7 partial ruptures. At 11 (SD 1.9) years, the median RPTT was 3.7 mm (1.5–6.3, 25th − 75th percentile). Seven knees displayed radiographic osteoarthritis approximating Kellgren-Lawrence grade ≥ 2. All follow-up MRIs displayed continuity of the PCL. Patients with more severe RPTT (> 3.7 mm), had worse scores in the KOOS subscales for symptoms (mean difference 14.5, 95% CI 7–22), sport/recreation (30, 95% CI 0–65) and quality of life (25, 95% CI 13–57) than those with less severe RPTT (≤ 3.7 mm). This was also the case for the KOOS4 (22, 95% CI 9–34). Conclusion Acute PCL injuries treated non-surgically display a high degree of PCL continuity on MR images 11 years after injury. However, there is a large variation of posterior tibial translation with higher values being associated with poorer patient-reported outcomes.
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- 2023
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18. Secondary Vocational Education in Finland
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Merilainen, Raija, Isacsson, Annica, and Olson, Susan
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Finland continues to lead the world in the global Program for International Student Assessment (PISA) results (Ministry of Education and Culture, 2016). Much has been written about Finland's common basic curriculum for all (grades one to nine), however little has been shared regarding Finland's secondary vocational education programs. Finland has a dual system of secondary education: academic and vocational. In Finland, education is a civic right for all children (and adults). Finland invest in their children from birth. All children receive tuition free preschool/daycare starting at age one, and a common comprehensive public-school education (grades one to nine) starting at age 7 (Sahlberg, 2015). At the age of 16, half of all students select vocational education as their secondary education curriculum. This article describes how Finland's secondary vocational education programs recent growth and change as well as early outcomes of this growth.
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- 2018
19. Swedish multimodal cohort of patients with anxiety or depression treated with internet-delivered psychotherapy (MULTI-PSYCH)
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David Mataix-Cols, Christian Rück, Lorena Fernández de la Cruz, Bjorn Roelstraete, Viktor Kaldo, Erik Forsell, Nils Lindefors, Ekaterina Ivanova, James J Crowley, Manuel Mattheisen, Magnus Boman, Julia Boberg, Matthew Halvorsen, Nils H Isacsson, Patrick F Sullivan, Cecilia Svanborg, Evelyn H Andersson, Olly Kravchenko, Hilda B Danielsdottir, and John Wallert
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Medicine - Abstract
Purpose Depression and anxiety afflict millions worldwide causing considerable disability. MULTI-PSYCH is a longitudinal cohort of genotyped and phenotyped individuals with depression or anxiety disorders who have undergone highly structured internet-based cognitive-behaviour therapy (ICBT). The overarching purpose of MULTI-PSYCH is to improve risk stratification, outcome prediction and secondary preventive interventions. MULTI-PSYCH is a precision medicine initiative that combines clinical, genetic and nationwide register data.Participants MULTI-PSYCH includes 2668 clinically well-characterised adults with major depressive disorder (MDD) (n=1300), social anxiety disorder (n=640) or panic disorder (n=728) assessed before, during and after 12 weeks of ICBT at the internet psychiatry clinic in Stockholm, Sweden. All patients have been blood sampled and genotyped. Clinical and genetic data have been linked to several Swedish registers containing a wide range of variables from patient birth up to 10 years after the end of ICBT. These variable types include perinatal complications, school grades, psychiatric and somatic comorbidity, dispensed medications, medical interventions and diagnoses, healthcare and social benefits, demographics, income and more. Long-term follow-up data will be collected through 2029.Findings to date Initial uses of MULTI-PSYCH include the discovery of an association between PRS for autism spectrum disorder and response to ICBT, the development of a machine learning model for baseline prediction of remission status after ICBT in MDD and data contributions to genome wide association studies for ICBT outcome. Other projects have been launched or are in the planning phase.Future plans The MULTI-PSYCH cohort provides a unique infrastructure to study not only predictors or short-term treatment outcomes, but also longer term medical and socioeconomic outcomes in patients treated with ICBT for depression or anxiety. MULTI-PSYCH is well positioned for research collaboration.
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- 2023
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20. Jaw function after oral appliance treatment of obstructive sleep apnea.
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Dr Eva Nohlert, Prof Åke Tegelberg, Prof Thomas List, and Assoc prof Göran Isacsson
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Dentistry ,RK1-715 - Abstract
Aim or Purpose: To assess changes in symptoms and clinical findings related to jaw function after 1 year of treating Obstructive Sleep Apnea (OSA) with an Oral Appliance (OA). Material and Methods: 302 patients (males 76%) with OSA were randomized to bibloc (n=146) or monobloc (n=156) appliance treatment (with previously reported equal efficacy). At baseline and at 1-y-follow-up a questionnaire related to symptoms and signs was used, including i.a. Jaw Functional Limitation Scale (JFLS-8). Furthermore, a clinical examination of jaw function and mobility, dental occlusion and tenderness in temporomandibular joints (TMJs) and masticatory muscles was performed. Results: 192 patients completed the 1-y follow-up (males 73%, mean age 55; sd 11).No change was seen at the follow-up in JFLS score or in clinical measurements of jaw mobility, dental occlusion or pain/tenderness upon palpation of TMJs and masticatory muscles.The patients described no change in symptoms at the follow-up, except for reduced morning headache (p
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- 2023
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21. Rapid classification of quantum sources enabled by machine learning
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Kudyshev, Zhaxylyk A., Bogdanov, Simeon, Isacsson, Theodor, Kildishev, Alexander V., Boltasseva, Alexandra, and Shalaev, Vladimir M.
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Physics - Optics ,Quantum Physics - Abstract
Deterministic nanoassembly may enable unique integrated on-chip quantum photonic devices. Such integration requires a careful large-scale selection of nanoscale building blocks such as solid-state single-photon emitters by the means of optical characterization. Second-order autocorrelation is a cornerstone measurement that is particularly time-consuming to realize on a large scale. We have implemented supervised machine learning-based classification of quantum emitters as "single" or "not-single" based on their sparse autocorrelation data. Our method yields a classification accuracy of over 90% within an integration time of less than a second, realizing roughly a hundredfold speedup compared to the conventional, Levenberg-Marquardt approach. We anticipate that machine learning-based classification will provide a unique route to enable rapid and scalable assembly of quantum nanophotonic devices and can be directly extended to other quantum optical measurements., Comment: Adv. Quantum Technol. 2020
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- 2019
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22. Optomechanical measurement of thermal transport in two-dimensional MoSe2 lattices
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Morell, Nicolas, Tepsic, Slaven, Reserbat-Plantey, Antoine, Cepellotti, Andrea, Manca, Marco, Epstein, Itai, Isacsson, Andreas, Marie, Xavier, Mauri, Francesco, and Bachtold, Adrian
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Optics - Abstract
Nanomechanical resonators have emerged as sensors with exceptional sensitivities. These sensing capabilities open new possibilities in the studies of the thermodynamic properties in condensed matter. Here, we use mechanical sensing as a novel approach to measure the thermal properties of low-dimensional materials. We measure the temperature dependence of both the thermal conductivity and the specific heat capacity of a transition metal dichalcogenide (TMD) monolayer down to cryogenic temperature, something that has not been achieved thus far with a single nanoscale object. These measurements show how heat is transported by phonons in two-dimensional systems. Both the thermal conductivity and the specific heat capacity measurements are consistent with predictions based on first-principles.
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- 2019
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23. Graphene resonator as an ultrasound detector for generalized Love waves in a polymer film with two level states
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Laitinen, Antti, Kaikkonen, Jukka-Pekka, Abhilash, Thanniyil S., Todoshchenko, Igor, Manninen, Juuso, Zavyalov, Vladislav, Savin, Alexander, Isacsson, Andreas, and Hakonen, Pertti J.
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Condensed Matter - Materials Science ,Physics - Applied Physics - Abstract
We have investigated surface shear waves at 22 MHz in a 0.5-micron-thick polymer film on SiO2/Si substrate at low temperatures using suspended and non-suspended graphene as detectors. By tracking ultrasound modes detected by oscillations of a trilayer graphene membrane both in vacuum and in helium superfluid, we assign the resonances to surface shear modes, generalized Love waves, in the resist/silicon-substrate system loaded with gold. The propagation velocity of these shear modes displays a logarithmic temperature dependence below 1 K, which is characteristic for modification of the elastic properties of a disordered solid owing to a large density of two level state (TLS) systems. For the dissipation of the shear mode, we find a striking logarithmic temperature dependence, which indicates a basic relation between the speed of the surface wave propagation and the mode dissipation., Comment: 16 pages, 5 figures
- Published
- 2019
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24. Heat-to-Mechanical Energy Conversion in Graphene: Manifestation of Umklapp Enhancement with Strain
- Author
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Shiri, Daryoush and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Conversion of heat-flux, from a steady state temperature difference, to mechanical vibration is demonstrated in graphene nanoribbons using direct non-equilibrium molecular dynamics (NEMD). We observe that this effect is independent of the method of imposing the temperature gradient, heat flux as well as imposed boundary conditions. We propose that simply dividing the nanoribbon in long and short sections using a partially immobilized area will lead to excitation of long-wavelength vibrations in the long section of the nanoribbon. This results in simpler architectures for heat-to-vibration converter devices based on graphene or other 2D materials. Furthermore we observe that applying tensile axial strain to nanoribbons, facilitates vibrational instability by reducing the required threshold heat flux or temperature gradient. Finally, we discuss the role played by Umklapp scattering for physical mechanisms behind these observations., Comment: 9 Figures
- Published
- 2018
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25. PennyLane: Automatic differentiation of hybrid quantum-classical computations
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Bergholm, Ville, Izaac, Josh, Schuld, Maria, Gogolin, Christian, Ahmed, Shahnawaz, Ajith, Vishnu, Alam, M. Sohaib, Alonso-Linaje, Guillermo, AkashNarayanan, B., Asadi, Ali, Arrazola, Juan Miguel, Azad, Utkarsh, Banning, Sam, Blank, Carsten, Bromley, Thomas R, Cordier, Benjamin A., Ceroni, Jack, Delgado, Alain, Di Matteo, Olivia, Dusko, Amintor, Garg, Tanya, Guala, Diego, Hayes, Anthony, Hill, Ryan, Ijaz, Aroosa, Isacsson, Theodor, Ittah, David, Jahangiri, Soran, Jain, Prateek, Jiang, Edward, Khandelwal, Ankit, Kottmann, Korbinian, Lang, Robert A., Lee, Christina, Loke, Thomas, Lowe, Angus, McKiernan, Keri, Meyer, Johannes Jakob, Montañez-Barrera, J. A., Moyard, Romain, Niu, Zeyue, O'Riordan, Lee James, Oud, Steven, Panigrahi, Ashish, Park, Chae-Yeun, Polatajko, Daniel, Quesada, Nicolás, Roberts, Chase, Sá, Nahum, Schoch, Isidor, Shi, Borun, Shu, Shuli, Sim, Sukin, Singh, Arshpreet, Strandberg, Ingrid, Soni, Jay, Száva, Antal, Thabet, Slimane, Vargas-Hernández, Rodrigo A., Vincent, Trevor, Vitucci, Nicola, Weber, Maurice, Wierichs, David, Wiersema, Roeland, Willmann, Moritz, Wong, Vincent, Zhang, Shaoming, and Killoran, Nathan
- Subjects
Quantum Physics ,Computer Science - Emerging Technologies ,Computer Science - Machine Learning ,Physics - Computational Physics - Abstract
PennyLane is a Python 3 software framework for differentiable programming of quantum computers. The library provides a unified architecture for near-term quantum computing devices, supporting both qubit and continuous-variable paradigms. PennyLane's core feature is the ability to compute gradients of variational quantum circuits in a way that is compatible with classical techniques such as backpropagation. PennyLane thus extends the automatic differentiation algorithms common in optimization and machine learning to include quantum and hybrid computations. A plugin system makes the framework compatible with any gate-based quantum simulator or hardware. We provide plugins for hardware providers including the Xanadu Cloud, Amazon Braket, and IBM Quantum, allowing PennyLane optimizations to be run on publicly accessible quantum devices. On the classical front, PennyLane interfaces with accelerated machine learning libraries such as TensorFlow, PyTorch, JAX, and Autograd. PennyLane can be used for the optimization of variational quantum eigensolvers, quantum approximate optimization, quantum machine learning models, and many other applications., Comment: Code available at https://github.com/XanaduAI/pennylane/ . Significant contributions to the code (new features, new plugins, etc.) will be recognized by the opportunity to be a co-author on this paper
- Published
- 2018
26. Predicting remission after internet-delivered psychotherapy in patients with depression using machine learning and multi-modal data
- Author
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John Wallert, Julia Boberg, Viktor Kaldo, David Mataix-Cols, Oskar Flygare, James J. Crowley, Matthew Halvorsen, Fehmi Ben Abdesslem, Magnus Boman, Evelyn Andersson, Nils Hentati Isacsson, Ekaterina Ivanova, and Christian Rück
- Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract This study applied supervised machine learning with multi-modal data to predict remission of major depressive disorder (MDD) after psychotherapy. Genotyped adult patients (n = 894, 65.5% women, age 18–75 years) diagnosed with mild-to-moderate MDD and treated with guided Internet-based Cognitive Behaviour Therapy (ICBT) at the Internet Psychiatry Clinic in Stockholm were included (2008–2016). Predictor types were demographic, clinical, process (e.g., time to complete online questionnaires), and genetic (polygenic risk scores). Outcome was remission status post ICBT (cut-off ≤10 on MADRS-S). Data were split into train (60%) and validation (40%) given ICBT start date. Predictor selection employed human expertise followed by recursive feature elimination. Model derivation was internally validated through cross-validation. The final random forest model was externally validated against a (i) null, (ii) logit, (iii) XGBoost, and (iv) blended meta-ensemble model on the hold-out validation set. Feature selection retained 45 predictors representing all four predictor types. With unseen validation data, the final random forest model proved reasonably accurate at classifying post ICBT remission (Accuracy 0.656 [0.604, 0.705], P vs null model = 0.004; AUC 0.687 [0.631, 0.743]), slightly better vs logit (bootstrap D = 1.730, P = 0.084) but not vs XGBoost (D = 0.463, P = 0.643). Transparency analysis showed model usage of all predictor types at both the group and individual patient level. A new, multi-modal classifier for predicting MDD remission status after ICBT treatment in routine psychiatric care was derived and empirically validated. The multi-modal approach to predicting remission may inform tailored treatment, and deserves further investigation to attain clinical usefulness.
- Published
- 2022
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27. Charge sensitivity enhancement via mechanical oscillation in suspended carbon nanotube devices
- Author
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Häkkinen, Pasi, Isacsson, Andreas, Savin, Alexander, Sulkko, Jaakko, and Hakonen, Pertti
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Single electron transistors (SETs) fabricated from single-walled carbon nanotubes (SWNTs) can be operated as highly sensitive charge detectors reaching sensitivity levels comparable to metallic radio frequency SETs (rf-SETs). Here we demonstrate how the charge sensitivity of the device can be improved by using the mechanical oscillations of a single-walled carbon nanotube quantum dot. To optimize the charge sensitivity $\delta Q$, we drive the mechanical resonator far into the nonlinear regime and bias it to an operating point where the mechanical third order nonlinearity is cancelled out. This way we enhance $\delta Q$, from 6 $\mu e/\sqrt{\textrm{Hz}}$ for the static case, to 0.97 $\mu e/\sqrt{\textrm{Hz}}$, at a probe frequency of $\sim$ 1.3 kHz., Comment: 8 pages + 12 page supplement
- Published
- 2018
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28. Bio‐Graphene Sensors for Monitoring Moisture Levels in Wood and Ambient Environment
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Mohammad Yusuf Mulla, Patrik Isacsson, Illia Dobryden, Valerio Beni, Emma Östmark, Karl Håkansson, and Jesper Edberg
- Subjects
cellulose ,humidity sensors ,laser‐induced graphene ,lignin ,moisture sensors ,wood ,Technology ,Environmental sciences ,GE1-350 - Abstract
Abstract Wood is an inherently hygroscopic material which tends to absorb moisture from its surrounding. Moisture in wood is a determining factor for the quality of wood being employed in construction, since it causes weakening, deformation, rotting, and ultimately leading to failure of the structures resulting in costs to the economy, the environment, and to the safety of residents. Therefore, monitoring moisture in wood during the construction phase and after construction is vital for the future of smart and sustainable buildings. Employing bio‐based materials for the construction of electronics is one way to mitigate the environmental impact of such electronics. Herein, a bio‐graphene sensor for monitoring the moisture inside and around wooden surfaces is fabricated using laser‐induced graphitization of a lignin‐based ink precursor. The bio‐graphene sensors are used to measure humidity in the range of 10% up to 90% at 25 °C. Using laser induced graphitization, conductor resistivity of 18.6 Ω sq−1 is obtained for spruce wood and 57.1 Ω sq−1 for pine wood. The sensitivity of sensors fabricated on spruce and pine wood is 2.6 and 0.74 MΩ per % RH. Surface morphology and degree of graphitization are investigated using scanning electron microscopy, Raman spectroscopy, and thermogravimetric analysis methods.
- Published
- 2023
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29. Predicting remission after internet-delivered psychotherapy in patients with depression using machine learning and multi-modal data
- Author
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Wallert, John, Boberg, Julia, Kaldo, Viktor, Mataix-Cols, David, Flygare, Oskar, Crowley, James J., Halvorsen, Matthew, Ben Abdesslem, Fehmi, Boman, Magnus, Andersson, Evelyn, Hentati Isacsson, Nils, Ivanova, Ekaterina, and Rück, Christian
- Published
- 2022
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30. Gunn Effect in Silicon Nanowires: Charge Transport under High Electric Field
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Shiri, Daryoush, Verma, Amit, Nekovei, Reza, Isacsson, Andreas, Selvakumar, C. R., and Anantram, M. P.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Gunn (or Gunn-Hilsum) Effect and its associated negative differential resistivity (NDR) emanates from transfer of electrons between two different energy bands in a semiconductor. If applying a voltage (electric field) transfers electrons from an energy sub band of a low effective mass to a second one with higher effective mass, then the current drops. This manifests itself as a negative slope or NDR in the I-V characteristics of the device which is in essence due to the reduction of electron mobility. Recalling that mobility is inversely proportional to electron effective mass or curvature of the energy sub band. This effect was observed in semiconductors like GaAs which has direct bandgap of very low effective mass and its second indirect sub band is about 300 meV above the former. More importantly a self-repeating oscillation of spatially accumulated charge carriers along the transport direction occurs which is the artifact of NDR, a process which is called Gunn oscillation and was observed by J. B. Gunn. In sharp contrast to GaAs, bulk silicon has a very high energy spacing (~1 eV) which renders the initiation of transfer-induced NDR unobservable. Using Density Functional Theory (DFT), semi-empirical 10 orbital ($sp^{3}d^{5}s^{*}$) Tight Binding (TB) method and Ensemble Monte Carlo (EMC) simulations we show for the first time that (a) Gunn Effect can be induced in narrow silicon nanowires with diameters of 3.1 nm under 3 % tensile strain and an electric field of 5000 V/cm, (b) the onset of NDR in I-V characteristics is reversibly adjustable by strain and (c) strain can modulate the value of resistivity by a factor 2.3 for SiNWs of normal I-V characteristics i.e. those without NDR. These observations are promising for applications of SiNWs in electromechanical sensors and adjustable microwave oscillators., Comment: 18 pages, 6 figures, 63 references
- Published
- 2017
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31. Strong mechanically-induced effects in DC current-biased suspended Josephson junctions
- Author
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McDermott, Thomas, Deng, Hai-Yao, Isacsson, Andreas, and Mariani, Eros
- Subjects
Condensed Matter - Superconductivity - Abstract
Superconductivity is a result of quantum coherence at macroscopic scales. Two superconductors separated by a metallic or insulating weak link exhibit the AC Josephson effect - the conversion of a DC voltage bias into an AC supercurrent. This current may be used to activate mechanical oscillations in a suspended weak link. As the DC voltage bias condition is remarkably difficult to achieve in experiments, here we analyse theoretically how the Josephson effect can be exploited to activate and detect mechanical oscillations in the experimentally relevant condition with purely DC current bias. We unveil for the first time how changing the strength of the electromechanical coupling results in two qualitatively different regimes showing dramatic effects of the oscillations on the DC current-voltage characteristic of the device. These include the apperance of Shapiro-like plateaux for weak coupling and a sudden mechanically-induced retrapping for strong coupling. Our predictions, measurable in state of the art experimental setups, allow the determination of the frequency and quality factor of the resonator using DC only techniques., Comment: 10 pages, 6 figures
- Published
- 2017
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32. Dynamic in situ Control of Heat Rectification in Graphene Nano Ribbons using Electric Field-induced Strain
- Author
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Shiri, Daryoush and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
An increasing number of papers propose routes to implement thermal counterparts of electronic rectification. These schemes are mainly based on combinations of crystal anharmonicity and broken mirror symmetry. With respect to graphene, proposals pivot around shape asymmetry induced by using hetero-structures of nano-patterned or defected sections of pristine graphene. Using Molecular Dynamics (MD) we show that it suffices to split a graphene nano-ribbon into two unequal strained sections using external force which leads to large asymmetry in the forward and reverse heat fluxes. We find that the corresponding rectification ratio is enhanced by up to 60 %. Also, and more importantly, the polarity is controllable on-the-fly, i.e. by changing the position where force is applied. Based upon our results we propose a thermo-electric device which obviates the complex nano-patterning and lithography required to pattern graphene every time a new rectification value or sign is sought for, opening a route to simpler fabrication and characterization of phononic phenomena in 2D materials., Comment: 9 pages, 5 figures
- Published
- 2017
33. Stepwise relaxation and stochastic precession in degenerate oscillators dispersively coupled to particles
- Author
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Rhen, Christin and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
By numerical integration, we study the relaxation dynamics of degenerate harmonic oscillator modes dispersively coupled to particle positions. Depending on whether the effective inertial potential induced by the oscillators keep the particles confined, or if the particle trajectories traverse the system, the local oscillator energy dissipation rate changes drastically. The inertial trapping, release and retrapping of particles results in a characteristic step-wise relaxation process, with alternating regions of fast and slow dissipation. To demonstrate this phenomenon we consider first a one-dimensional minimal prototype model which displays these characteristics. We then treat the effect of dispersive interaction in a model corresponding to an adsorbate diffusing on a circular membrane interacting with its three lowest vibrational modes. In the latter model, stepwise relaxation appears only in the presence of thermal noise, which also causes a slow-in-time stochastic precession of the mixing angle between the degenerate eigenmodes., Comment: 9 pages, 8 figures
- Published
- 2017
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34. Switching off energy decay channels in nanomechanical resonators
- Author
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Guettinger, J., Noury, A., Weber, P., Eriksson, A. M., Lagoin, C., Moser, J., Eichler, C., Wallraff, A., Isacsson, A., and Bachtold, A.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Energy decay plays a central role in a wide range of phenomena, such as optical emission, nuclear fission, and dissipation in quantum systems. Energy decay is usually described as a system leaking energy irreversibly into an environmental bath. Here, we report on energy decay measurements in nanomechanical systems based on multi-layer graphene that cannot be explained by the paradigm of a system directly coupled to a bath. As the energy of a vibrational mode freely decays, the rate of energy decay switches abruptly to a lower value. This finding can be explained by a model where the measured mode hybridizes with other modes of the resonator at high energy. Below a threshold energy, modes are decoupled, resulting in comparatively low decay rates and giant quality factors exceeding 1 million. Our work opens up new possibilities to manipulate vibrational states, engineer hybrid states with mechanical modes at completely different frequencies, and to study the collective motion of this highly tunable system., Comment: 14 pages, 5 figures
- Published
- 2016
35. Scaling Properties of Polycrystalline Graphene: A Review
- Author
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Isacsson, Andreas, Cummings, Aron W., Colombo, Luciano, Colombo, Luigi, Kinaret, Jari M., and Roche, Stephan
- Subjects
Condensed Matter - Materials Science - Abstract
We present an overview of the electrical, mechanical, and thermal properties of polycrystalline graphene. Most global properties of this material, such as the charge mobility, thermal conductivity, or Young's modulus, are sensitive to its microstructure, for instance the grain size and the presence of line or point defects. Both the local and global features of polycrystalline graphene have been investigated by a variety of simulations and experimental measurements. In this review, we summarize the properties of polycrystalline graphene, and by establishing a perspective on how the microstructure impacts its large-scale physical properties, we aim to provide guidance for further optimization and improvement of applications based on this material, such as flexible and wearable electronics, and high-frequency or spintronic devices., Comment: 14 pages, 7 figures. Accepted for publications in 2D Materials
- Published
- 2016
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36. Noise-tunable nonlinearity in a dispersively coupled diffusion-resonator system using superconducting circuits
- Author
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Rhén, Christin and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The harmonic oscillator is one of the most widely used model systems in physics: an indispensable theoretical tool in a variety of fields. It is well known that otherwise linear oscillators can attain novel and nonlinear features through interaction with another dynamical system. We investigate such an interacting system: a superconducting LC-circuit dispersively coupled to a superconducting quantum interference device (SQUID). We find that the SQUID phase behaves as a classical two-level system, whose two states correspond to one linear and one nonlinear regime for the LC-resonator. As a result, the circuit's response to forcing can become multistable. The strength of the nonlinearity is tuned by the level of noise in the system, and increases with decreasing noise. This tunable nonlinearity could potentially find application in the field of sensitive detection, whereas increased understanding of the classical harmonic oscillator is relevant for studies of the quantum-to-classical crossover of Jaynes-Cummings systems., Comment: 8 pages, 8 figures
- Published
- 2016
37. Particle number scaling for diffusion-induced dissipation in graphene and carbon nanotube nanomechanical resonators
- Author
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Rhén, Christin and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
When a contaminant diffuses on the surface of a nanomechanical resonator, the motions of the two become correlated. Despite being a high-order effect in the resonator-particle coupling, such correlations affect the system dynamics by inducing dissipation of the resonator energy. Here, we consider this diffusion-induced dissipation in the cases of multiple particles adsorbed on carbon nanotube and graphene resonators. By solving the stochastic equations of motion, we simulate the ringdown of the resonator, in order to determine the resonator energy decay rate. We find two different scalings with the number of adsorbed particles $K$ and particle mass $m$. In the regime where the adsorbates are inertially trapped at an antinode of vibration, the dissipation rate $\Gamma$ scales with the total adsorbed mass $\Gamma\propto Km$. In contrast, in the regime where particles diffuse freely over the resonator, the dissipation rate scales as the product of the total adsorbed mass and the individual particle mass: $\Gamma\propto Km^2$., Comment: 6 pages, 5 figures
- Published
- 2015
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38. Buckled Diamond-like Carbon Nanomechanical Resonators
- Author
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Tomi, Matti, Isacsson, Andreas, Oksanen, Mika, Lyashenko, Dmitry, Kaikkonen, Jukka-Pekka, Tervakangas, Sanna, Kolehmainen, Jukka, and Hakonen, Pertti
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We have developed capacitively-transduced nanomechanical resonators using sp$^2$-rich diamond-like carbon (DLC) thin films as conducting membranes. The electrically conducting DLC films were grown by physical vapor deposition at a temperature of $500{\,\,}^\circ$C. Characterizing the resonant response, we find a larger than expected frequency tuning that we attribute to the membrane being buckled upwards, away from the bottom electrode. The possibility of using buckled resonators to increase frequency tuning can be of advantage in rf applications such as tunable GHz filters and voltage-controlled oscillators., Comment: 5 + 4 pages, 3 + 4 figures
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- 2015
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39. Investigating powerful jets in radio-loud Narrow Line Seyfert 1s
- Author
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Orienti, M., D'Ammando, F., Larsson, J., Finke, J., Giroletti, M., Dallacasa, D., Isacsson, T., and Hoglund, J. Stoby
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
We report results on multiband observations from radio to gamma-rays of the two radio-loud narrow-line Seyfert 1 (NLSy1) galaxies PKS 2004-447 and J1548+3511. Both sources show a core-jet structure on parsec scale, while they are unresolved at the arcsecond scale. The high core dominance and the high variability brightness temperature make these NLSy1 galaxies good gamma-ray source candidates. Fermi-LAT detected gamma-ray emission only from PKS 2004-447, with a gamma-ray luminosity comparable to that observed in blazars. No gamma-ray emission is observed for J1548+3511. Both sources are variable in X-rays. J1548+3511 shows a hardening of the spectrum during high activity states, while PKS 2004-447 has no spectral variability. A spectral steepening likely related to the soft excess is hinted below 2 keV for J1548+3511, while the X-ray spectra of PKS 2004-447 collected by XMM-Newton in 2012 are described by a single power-law without significant soft excess. No additional absorption above the Galactic column density or the presence of an Fe line is detected in the X-ray spectra of both sources., Comment: 16 pages, 8 figures, accepted for publication in MNRAS
- Published
- 2015
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40. Diffraction and near-zero transmission of flexural phonons at graphene grain boundaries
- Author
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Helgee, Edit E. and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
Graphene grain boundaries are known to affect phonon transport and thermal conductivity, suggesting that they may be used to engineer the phononic properties of graphene. Here, the effect of two buckled grain boundaries on long-wavelength flexural acoustic phonons has been investigated as a function of angle of incidence using molecular dynamics. The flexural acoustic mode has been chosen due to its importance to thermal transport. It is found that the transmission through the boundaries is strongly suppressed for incidence angles close to 35$^\circ$. Also, the grain boundaries are found to act as diffraction gratings for the phonons.
- Published
- 2015
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41. Entanglement Dynamics of Quantum Oscillators Nonlinearly Coupled to Thermal Environments
- Author
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Voje, Aurora, Croy, Alexander, and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
We study the asymptotic entanglement of two quantum harmonic oscillators nonlinearly coupled to an environment. Coupling to independent baths and a common bath are investigated. Numerical results obtained using the Wangsness-Bloch-Redfield method are supplemented by analytical results in the rotating wave approximation. The asymptotic negativity as function of temperature, initial squeezing and coupling strength, is compared to results for systems with linear system-reservoir coupling. We find that due to the parity conserving nature of the coupling, the asymptotic entanglement is considerably more robust than for the linearly damped cases. In contrast to linearly damped systems, the asymptotic behavior of entanglement is similar for the two bath configurations in the nonlinearly damped case. This is due to the two-phonon system-bath exchange causing a supression of information exchange between the oscillators via the bath in the common bath configuration at low temperatures., Comment: 9 pages, 5 figures, revtex
- Published
- 2014
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42. Diffusion-induced dissipation and mode coupling in nanomechanical resonators
- Author
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Edblom, Christin and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We study a system consisting of a particle adsorbed on a carbon nanotube resonator. The particle is allowed to diffuse along the resonator, in order to enable study of e.g. room temperature mass sensing devices. The system is initialized in a state where only the fundamental vibration mode is excited, and the ring-down of the system is studied by numerically and analytically solving the stochastic equations of motion. We find two mechanisms of dissipation, induced by the diffusing adsorbate. First, short-time correlations between particle and resonator motions means that the net effect of the former on the latter does not average out, but instead causes dissipation of vibrational energy. For vibrational amplitudes that are much larger than the thermal energy this dissipation is linear; for small amplitudes the decay takes the same form as that of a nonlinearly damped oscillator. Second, the particle diffusion mediates a coupling between vibration modes, enabling energy transfer from the fundamental mode to excited modes, which rapidly reach thermal equilibrium., Comment: 8 pages, 7 figures
- Published
- 2014
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43. Scattering of flexural acoustic phonons at grain boundaries in graphene
- Author
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Helgee, Edit E. and Isacsson, Andreas
- Subjects
Condensed Matter - Materials Science ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We investigate the scattering of long-wavelength flexural phonons against grain boundaries in graphene using molecular dynamics simulations. Three symmetric tilt grain boundaires are considered: one with a misorientation angle of $17.9^\circ$ displaying an out-of-plane buckling 1.5 nm high and 5 nm wide, one with a misorientation angle of $9.4^\circ$ and an out-of-plane buckling 0.6 nm high and 1.7 nm wide, and one with a misorientation angle of $32.2^\circ$ and no out-of-plane buckling. At the flat grain boundary, the phonon transmission exceeds 95 % for wavelengths above 1 nm. The buckled boundaries have a substantially lower transmission in this wavelength range, with a minimum transmission of 20 % for the $17.9^\circ$ boundary and 40 % for the $9.4^\circ$ boundary. At the buckled boundaries, coupling between flexural and longitudinal phonon modes is also observed. The results indicate that scattering of long-wavelength flexural phonons at grain boundaries in graphene is mainly due to out-of-plane buckling. A continuum mechanical model of the scattering process has been developed, providing a deeper understanding of the scattering process as well as a way to calculate the effect of a grain boundary on long-wavelength flexural phonons based on the buckling size., Comment: 11 pages, 14 figures
- Published
- 2014
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44. Nonlinear phononics using atomically thin membranes
- Author
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Midtvedt, Daniel, Isacsson, Andreas, and Croy, Alexander
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Phononic crystals and acoustic meta-materials are used to tailor phonon and sound propagation properties by facilitating artificial, periodic structures. Analogous to photonic crystals, phononic band gaps can be created, which influence wave propagation and, more generally, allow engineering of the acoustic properties of a system. Beyond that, nonlinear phenomena in periodic structures have been extensively studied in photonic crystals and atomic Bose-Einstein Condensates in optical lattices. However, creating nonlinear phononic crystals or nonlinear acoustic meta-materials remains challenging and only few examples have been demonstrated. Here we show that atomically thin and periodically pinned membranes support coupled localized modes with nonlinear dynamics. The proposed system provides a platform for investigating nonlinear phononics.
- Published
- 2014
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45. FPU physics with nanomechanical graphene resonators: intrinsic relaxation and thermalization from flexural mode coupling
- Author
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Midtvedt, Daniel, Qi, Zenan, Croy, Alexander, Park, Harold S., and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Thermalization in nonlinear systems is a central concept in statistical mechanics and has been extensively studied theoretically since the seminal work of Fermi, Pasta and Ulam (FPU). Using molecular dynamics and continuum modeling of a ring-down setup, we show that thermalization due to nonlinear mode coupling intrinsically limits the quality factor of nanomechanical graphene drums and turns them into potential test beds for FPU physics. We find the thermalization rate $\Gamma$ to be independent of radius and scaling as $\Gamma\sim T^*/\epsilon_{{\rm pre}}^2$, where $T^*$ and $\epsilon_{{\rm pre}}$ are effective resonator temperature and prestrain.
- Published
- 2013
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46. Nonlinear-dissipation-induced Entanglement of Coupled Nonlinear Oscillators
- Author
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Voje, Aurora, Isacsson, Andreas, and Croy, Alexander
- Subjects
Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
The quantum dynamics of two weakly coupled nonlinear oscillators is analytically and numerically investigated in the context of nonlinear dissipation. The latter facilitates the creation and preservation of non-classical steady states. Starting from a microscopic description of two oscillators individually interacting with their dissipative environments, it is found that in addition to energy relaxation, dephasing arises due to the mutual coupling. Using the negativity as an entanglement measure, it is shown that the coupling entangles the oscillators in the long-time limit. For finite temperatures, entanglement sudden death and rebirth are observed., Comment: 4.5 pages, 3 figures; minor revisions, accepted for publication in PRA
- Published
- 2013
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47. Frequency tuning, nonlinearities and mode coupling in circular graphene resonators
- Author
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Eriksson, A. M., Midtvedt, D., Croy, A., and Isacsson, A.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We study circular nanomechanical graphene resonators by means of continuum elasticity theory, treating them as membranes. We derive dynamic equations for the flexural mode amplitudes. Due to geometrical nonlinearity these can be modeled by coupled Duffing equations. By solving the Airy stress problem we obtain analytic expressions for eigenfrequencies and nonlinear coefficients as functions of radius, suspension height, initial tension, back-gate voltage and elastic constants, which we compare with finite element simulations. Using perturbation theory, we show that it is necessary to include the effects of the non-uniform stress distribution for finite deflections. This correctly reproduces the spectrum and frequency tuning of the resonator, including frequency crossings., Comment: 21 pages, 7 figures, 3 tables
- Published
- 2013
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48. Learning machines in Internet-delivered psychological treatment
- Author
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Boman, Magnus, Ben Abdesslem, Fehmi, Forsell, Erik, Gillblad, Daniel, Görnerup, Olof, Isacsson, Nils, Sahlgren, Magnus, and Kaldo, Viktor
- Published
- 2019
- Full Text
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49. Multi-phonon relaxation and generation of quantum states in a nonlinear mechanical oscillator
- Author
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Voje, Aurora, Croy, Alexander, and Isacsson, Andreas
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
The dissipative quantum dynamics of an anharmonic oscillator is investigated theoretically in the context of carbon-based nano-mechanical systems. In the short-time limit, it is known that macroscopic superposition states appear for such oscillators. In the long-time limit, single and multi-phonon dissipation lead to decoherence of the non-classical states. However, at zero temperature, as a result of two-phonon losses the quantum oscillator eventually evolves into a non-classical steady state. The relaxation of this state due to thermal excitations and one-phonon losses is numerically and analytically studied. The possibility of verifying the occurrence of the non-classical state is investigated and signatures of the quantum features arising in a ring-down setup are presented. The feasibility of the verification scheme is discussed in the context of quantum nano-mechanical systems., Comment: 23 pages, 8 figures; Minor revisions; Accepted for publication in NJP
- Published
- 2013
- Full Text
- View/download PDF
50. Nonlinear Damping in Graphene Resonators
- Author
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Croy, Alexander, Midtvedt, Daniel, Isacsson, Andreas, and Kinaret, Jari M.
- Subjects
Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Based on a continuum mechanical model for single-layer graphene we propose and analyze a microscopic mechanism for dissipation in nanoelectromechanical graphene resonators. We find that coupling between flexural modes and in-plane phonons leads to linear and nonlinear damping of out-of-plane vibrations. By tuning external parameters such as bias and ac voltages, one can cross over from a linear to a nonlinear-damping dominated regime. We discuss the behavior of the effective quality factor in this context., Comment: extended and revised version: 10 pages, 6 figures
- Published
- 2012
- Full Text
- View/download PDF
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