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Your search keyword '"Jesse Spivey"' showing total 2 results
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1. Carboxylate-Capped Analogues of Ru265 Are MCU Inhibitor Prodrugs

Author

Nicholas P. Bigham, Zhouyang Huang, Jesse Spivey, Joshua J. Woods, Samantha N. MacMillan, and Justin J. Wilson

Subjects
Inorganic Chemistry, HEK293 Cells, Formates, Humans, Calcium, Prodrugs, Physical and Theoretical Chemistry, Ligands
Abstract

The mitochondrial calcium uniporter (MCU) is a transmembrane protein that resides on the inner membrane of the mitochondria and mediates calcium uptake into this organelle. Given the critical role of mitochondrial calcium trafficking in cellular function, inhibitors of this channel have arisen as tools for studying the biological relevance of this process and as potential therapeutic agents. In this study, four new analogues of the previously reported Ru-based MCU inhibitor [ClRu(NH

Published
2022

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