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4 results on '"Jimenez, Auburn"'

3. Restless Legs Syndrome and the Law.

Author

Brown, Jerrod, Jimenez, Auburn, Krasowski, Matthew, Olson, Janae, Wresh, Janina, Weinkauf, Erv, Oberoi, Pamela, and Falconer, Gennae

Subjects
RESTLESS legs syndrome, PREGNANCY, IRON deficiency, ATTENTION-deficit hyperactivity disorder, INSOMNIA, BENZODIAZEPINE receptors
Abstract

Restless legs syndrome or RLS is a common neurological disorder prevalent in both adults and children and is often detrimental to regulatory sleep processes. RLS is subdivided into primary/idiopathic RLS and secondary RLS that is due to a related medical condition. Risk factors associated with the development of RLS include: pregnancy, iron deficiency, genetic heritability, and Attention Deficit Hyperactivity Disorder (ADHD). Additionally, RLS has high comorbidity with periodic limb movements during sleep (PLMS), insomnia, and nocturnal eating. Iron replacement and behavior therapy can be successful treatment approaches initially; however drug therapy (e.g., dopaminergic agents, opiates, and antiepileptic medications, and benzodiazepine receptor agonists) can be used in severe cases of RLS. The long-term prognosis of idiopathic RLS is not fatal; however, chronic secondary RLS can exacerbate associated medical conditions and present significant health risks. The symptoms of RLS have not been presented as detrimental to individual judgment and/or psyche. Thus, the Court has maintained the position that individuals with RLS are liable for any and all committed offenses. [ABSTRACT FROM AUTHOR]

Published
2013

4. Doxorubicin and zoledronate treatment in a dog with hemophagocytic histiocytic sarcoma.

Author

Soileau AM, Neto RLALT, Jimenez PT, Hamersky J, and Smith AA

Subjects
Dogs, Animals, Male, Zoledronic Acid therapeutic use, Lomustine, Doxorubicin therapeutic use, Hyperbilirubinemia drug therapy, Hyperbilirubinemia veterinary, Histiocytic Sarcoma drug therapy, Histiocytic Sarcoma veterinary, Histiocytic Sarcoma pathology, Hypoalbuminemia drug therapy, Hypoalbuminemia veterinary, Thrombocytopenia veterinary, Dog Diseases diagnosis
Abstract

A 6-year-old castrated male greyhound dog was referred for hemophagocytic histiocytic sarcoma (HHS) diagnosed following splenectomy. Severe thrombocytopenia, mild hypoalbuminemia, mild hypocholesterolemia, and mild hyperbilirubinemia were present. Abdominal ultrasound findings were concerning for hepatic metastasis. Doxorubicin and zoledronate combination therapy was initiated. The dog improved clinically and its thrombocytopenia, hypoalbuminemia, and hyperbilirubinemia resolved. The dog appeared well for 147 d before tumor progression was noted. The dog was treated with lomustine as a final measure, with no response. The dog survived for 6 mo with chemotherapy. To the authors' knowledge, this is the first report of clinical benefit of chemotherapy for HHS. Key clinical message: Doxorubicin should be considered for treating canine HHS since this variant of the disease is historically refractory to lomustine. Further research regarding efficacy of doxorubicin and zoledronate should be pursued., (Copyright and/or publishing rights held by the Canadian Veterinary Medical Association.)

Published
2023

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