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This paper is the result of empirical, qualitative research conducted with the aim of studying and gaining an understanding of the benefits of using film as an educational medium in higher education in terms of achieving educational outcomes, providing students with emotional and cognitive stimulation and engagement, and encouraging reflection and self-reflection through a relationship with film as a specific carrier of educational content, which occur in virtual learning environments. The convenience sample consisted of twelve students who attended the course Online Adult Education in 2017-18, and who were intensively engaged in activities that were part of the course's thematic unit Theories of Learning and Online Adult Education. The instructional material used as part of this unit was Akira Kurosawa's film Rashomon (1950). Through two research phases: the discussion phase, which was also the phase of data collection, and the phase of narrative, discourse and content analysis, as well as the grouping of the data obtained through discussion and their thematic analysis, we arrived at results which can also be understood as practical educational implications, and which unequivocally indicate that the use of film as an educational medium encourages: the emotional and cognitive stimulation of students, whether positive or negative; students' perseverance in carrying out assignments and the eventual achievement of learning objectives; introspection, which further defines the quality of learning insights, reflection and self-reflection aimed at attaining concrete learning objectives predefined by learning units.

Increasing the share of the elderly in the total population and the increase of the average age of the population is a feature of the demographic picture of Serbia and a process that will continue in the years to come. Although the share of the elderly in the total population is high, their knowledge and use of digital technologies is lower compared to other categories of the population. As a result, people over the age of 65 are at greater risk of digital exclusion, which results in not only social exclusion but also difficult access to public services and the exercise of other rights. Apart from the inadequate level of digital literacy and financial costs, the issues that most often demotivate older people to join the Internet community are related to security, namely financial security, privacy, data protection, the device itself, and other issues related to mental and moral security, personal integrity and physical health. The aim of this paper is to answer the research question: is the issue of cyber security of the elderly subject of Serbian and European adult education policies and how? Aside from scientific sources, legislative documents of the EU and Serbia related to older people and digitalization are also analyzed. The descriptive method was used, and within it the analysis of content, discourse and narrative. The analysis of EU and Serbian legislative documents related to lifelong learning and digitalization shows that the goals of digital education are primarily economic, and the real target group to which the analyzed documents are aimed at are persons under 65 years of age. The security of the elderly in the digital world is currently not a priority in either European or Serbian educational policies. The results of the research indicate that a more intensive and systematic support is needed for the development of digital competencies and security of the elderly on the Internet, and that the creation of educational models for the elderly is a necessary precondition for improving their position and their full participation in different aspects of life.

The work was written with the goal of determining and describing the contribution of Dimitrije Matić to establishing and developing adult education in Serbia in the 19th century. We employed the historical method and within it an analysis of content, discourse and narrative of primary and secondary sources. The results of the research demonstrate the exceptional contribution of Matić to the development of institutional adult education through the establishment of a network of reading rooms in Serbia, the (re)opening of adult schools, the constitution of school boards, and the renewal of teacher education. We identified contributions in the sphere of instituting adult education legislature and the creation of institutional, staff, program and financial prerequisites for the operation of adult education institutions. We identified the bases for questioning the success of the functioning of certain andragogical institutions established by Matić, which doesn't undermine his importance in the pioneering endeavours of developing adult education.

A brand could be named as the marketing goal of any organization, including the educational one. The issue of brand in education is becoming more and more actual, but the current focus of the scientifc community has remained mainly on branding higher education, while non-formal adult education organizations on this issue have been largely ignored. Therefore, we conducted research to determine whether users of non-formal education organizations perceive the educational service provider as a brand, as well as to identify which activities are carried out by non-formal education organizations to reach this level of connection with their users. The research used a combination of quantitative-qualitative research paradigm, with a multiple case study as a research model and a descriptive method as the dominant one. The research sample consists of managers and students of the analyzed foreign language schools. The results of the research indicate that non-formal education organizations in Serbia follow world trends and make efforts to achieve the status of an educational brand, that branding is not a uniform process, and that each organization and their strategies have certain specifcs.

The paper is dedicated to the analysis of the effects from teacher trainings which were developed and applied in Bosnia in Herzegovina (B&H), as a project activity within the larger project titled ''Support for adult education: subsequent acquisition of elementary adult education'', which was implemented during 2012-2013 by the GIZ and the Institute for International Cooperation of German Adult Education Association (DVV International), Office in Bosnia and Herzegovina. The reasons for initiating this training and the analysis of its effects are considered in a specific socio-historical and educational-political context, in order to analyze not only the inherited problems of illiteracy, but also the conditions in which the capacity for their resolution and building of a system of adult education are developing today. The methodological approach and findings of the research are presented, which is based on estimates of the teachers on the effects of the training in which they participated. Bearing in mind the insight into the context and findings of the research, possible directions for improvement in this field are suggested.

Next spring, we will celebrate 30 years since the first issue of Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) was published and, to our astonishment and disappointment, it seems that the goal we have long awaited (and worked hard for)-obtaining an official impact factor (IF)-is nowhere in sight. Every application for an IF has been met with various reasons why our journal does not fulfill the criteria for inclusion in the Science Citation Index Expanded (SCIE). Given the highly non-transparent evaluation process, we conclude that there probably really is no room for small and independent journals in the world of publishing giants and commercial interests. Although disheartened, we will continue our long-established tradition of providing open-access and quality content in dermatology and sexually transmitted infections for researchers and clinicians in the region and worldwide because science should be open and committed to teamwork.

Background: cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods: an international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest(R) performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results: of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p = .003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion: coldA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector., GA(2)LEN UCARE Network

Molluscum contagiosum virus (MCV) is the sole member of the Molluscipoxvirus genus and the causative agent of molluscum contagiosum (MC), a common skin disease. Although it is an important and frequent human pathogen, its genetic landscape and evolutionary history remain largely unknown. In this study, ten novel complete MCV genome sequences of the two most common MCV genotypes were determined (five MCV1 and five MCV2 sequences) and analyzed together with all MCV complete genomes previously deposited in freely accessible sequence repositories (four MCV1 and a single MCV2). In comparison to MCV1, a higher degree of nucleotide sequence conservation was observed among MCV2 genomes. Large-scale recombination events were identified in two newly assembled MCV1 genomes and one MCV2 genome. One recombination event was located in a newly identified recombinant region of the viral genome, and all previously described recombinant regions were re-identified in at least one novel MCV genome. MCV genes comprising the identified recombinant segments have been previously associated with viral interference with host T-cell and NK-cell immune responses. In conclusion, the two most common MCV genotypes emerged along divergent evolutionary pathways from a common ancestor, and the differences in the heterogeneity of MCV1 and MCV2 populations may be attributed to the strictness of the constraints imposed by the host immune response.

Fish tank granuloma is a rare skin infection caused by Mycobacterium marinum. It occurs after exposure of skin abrasions to contaminated water or infected fish. The majority of M. marinum infections today are fish tank-related. The most common presentation is a solitary nodule, often with sporotrichoid spread. Other presentations do not occur often. The diagnosis is often delayed because of lack of suspicion, nonspecific histopathological findings, and frequently unsuccessful cultivation. Here we present the case of a 37-year-old male with M. marinum skin infection, presenting as erythematous scaling plaques. Because the initial results of laboratory and histopathological examinations were negative for a fungal infection or nontuberculous mycobacteria, the patient was treated empirically with several systemic antibiotics and antifungals without any success. Finally, the diagnosis of fish tank granuloma was confirmed 3 months after the initial presentation of the patient. After the introduction of treatment with rifampicin and clarithromycin, complete clinical remission was observed after 6 months of therapy.

All activities, including education, are underpinned by values. Since its beginnings, education has promoted various values, and at the same time was itself perceived as a value, which is a prerequisite for performing its social function. The crisis of contemporary civilization makes it essentially important for school as an educational institution, and for teachers as its key actors, to demonstrate unequivocally by personal example that they perceive education as a value, not only declaratively but also through their professional activities. The current study aimed to explore teachers' perceptions of education as a value in school culture, specifically, their perceptions of education as a mechanism for promoting employees within an organization and their perceptions of measures and procedures in the organization aimed at facilitating employees' education. Our findings suggest that education is not regarded as an organizational value within the culture of the schools included in our study

Thanks to European integration, harmonization of policies, thus adult education policies as well, has become one of the inevitable andragogical topics. Due to its European commitment, but also because of its specific state organization, the process of harmonization of policies is of major scientific and practical importance for Bosnia and Herzegovina. the aim of the research, whose results we present here, is to determine whether and to what extent adult education policies in Bosnia and Herzegovina are harmonized. The results of the research, although generally indicating high level of harmonization, biasedly in some segments deviate from recommended umbrella document. The reasons for the identified discrepancies lie outside of adult education policy, in higher spheres of politics, and cannot be eliminated by applying solely educational intervention.

Background: Assessment of human papillomavirus (HPV) type-specific viral load (VL) is a valid tool for determining the etiology of HPV-related skin tumors, especially when more than one HPV type is detected within one lesion. Methods: The causative HPV type was determined in 185 fresh-frozen tissue specimens of histologically confirmed common warts (CWs) collected from 121 immunocompetent patients. All tissues were tested using the type-specific quantitative real-time polymerase chain reactions (PCR) for the most common wart-associated Alpha-PV (HPV2/27/57) and Mu-PV types (HPV1/63/204). The presence of 23 additional low-risk HPVs was evaluated using a conventional wide-spectrum PCR. Results: HPV DNA was detected in 176/185 (95.1%) CWs and multiple HPV types in 71/185 (38.4%) lesions. Using the VL approach and a robust cutoff of one viral copy/cell established in this study, HPV2/27/57 were determined as causative agents in 41/53 (77.3%) and 53/71 (74.7%) CWs with single and multiple HPVs, respectively. Conclusions: CWs are mostly etiologically associated with HPV2/27/57 and only rarely with HPV1. In the majority of CWs containing multiple HPVs, a single HPV type was present in high concentration, indicating etiological association. No significant differences in VLs of lesion-causing HPV types in CWs containing single or multiple HPVs were found.

INTRODUCTION Journal bibliometric indicators are useful tools in assessing the characteristics, development history, and future trending of a particular medical journal. Moreover, they can help potential authors when deciding which journal to submit their work to in order to achieve the highest visibility. METHODS A single journal study of the medical journal Acta Dermatovenerologica Alpina, Pannonica et Adriatica (ADAPA) from January 1994 to July 2019 was performed. The corpus was harvested from the bibliographical database Scopus (Elsevier, Netherlands) for the period between 1994 and 2019 (inclusive), and the bibliometric analysis was performed using Scopus built-in services and MS Excel (Microsoft, USA). The historical, cooperation, and hot topic analysis was performed on scientific landscapes induced by VOSviewer software (Leiden University, Netherlands). RESULTS From 1994 to 2019, a total of 759 publications were published in ADAPA. The trend in the number of publications has varied; it increased somewhat until 2009, then decreased until 2015, when the number of articles began to rise again, reaching a peak in 2018 (46 articles annually). A small decline in source normalized impact per paper (SNIP) was observed from 1.2 in 2010 to 0.46 in 2018. Slovenia ranked first (n = 210) in the number of publications among 55 countries. Authors from 44 out of 55 countries published their articles through co-authorships. CONCLUSIONS Whereas it was initially considered a primarily regional journal, ADAPA's influence has gradually broadened and the journal has become truly international. The number of articles published increased significantly during the last few years, with ADAPA strongly supporting international collaboration, resulting in a high proportion of international co-authorships.

Background Primary lymphoedema is a rare genetic disorder characterized by swelling of different parts of the body and highly heterogenic clinical presentation. Mutations in several causative genes characterize specific forms of the disease. FOXC2 mutations are associated with lymphoedema of lower extremities, usually distichiasis and late onset. Patients and methods Subjects from three generations of a family with lymphoedema of lower limbs without distichiasis were searched for mutations in the FOXC2 gene. Results All affected family members with lymphoedema of lower limbs without distichiasis, and still asymptomatic six years old girl from the same family, carried the same previously unreported insertion of adenosine (c.867insA) in FOXC2. Conclusions Identification of a novel mutation in the FOXC2 gene in affected family members of three generations with lymphoedema of lower limbs without distichiasis, highlights the high phenotypic variability caused by FOXC2 mutations.

In this paper we reaserch the theatrical performances regular visitors’ perception about the importance of certain elements of the marketing mix for choosing a theater performance. In the first part of the paper, we consider adragogical role of the theater in the context of its current position on the cultural market, as well as the importance of marketing for achieving andragogical functions of the theater. After presenting the methodological characteristics of this quantitative research, we presented and interpreted the results of the research, among which we highlight the price as the most significant estimated element of the theater’s marketing mix.

This paper deals with research of aspects of entrepreneurship in adult education at the level of analysis of theoretical statements, documents of educational policy and examples of good practice. The structure of the paper is made of sections on the content of entrepreneurial competence, educational paths of development of entrepreneurial competence and potential barriers in this process, the position of entrepreneurship in educational (and other public) policy of Europe and Serbia, the possibilities of including entrepreneurship in the area of adult education. In this context the interest of andragogy to study the entrepreneurship as an important social and economic phenomenon, and the possible contribution of andragogy as a science and adult education as practice to the development of entrepreneurial competence have been considered. The results of the analysis showed that entrepreneurship is present in education and other public policies, and the research in adult education can contribute to the improvement of educational policies focussed on the development of entrepreneurial competencies, as well as improvement of the environment and the educational paths of development of entrepreneurial competence.

A 72-year-old female patient presented with an end-stage renal disease on on-line hemodiafiltration and warfarin therapy with advanced ulcerated calciphylaxis on the lower extremities, complicated by two episodes of cellulitis. She was successfully treated for 8 months with intravenous sodium thiosulfate in combination with modification of medication and dialysis treatment, careful wound care, and other supportive measures. Calciphylaxis is an uncommon life-threatening systemic disease, mostly occurring in patients with chronic kidney disease and other risk factors. Vascular calcifications and inflammation lead to thrombotic occlusions of the cutaneous and subcutaneous arterioles, which provoke livedoid painful plaques with possible progression to necrotic ulcers. Conventional treatment is supportive. In recent decades, off-label treatment with sodium thiosulfate, a potent calcium chelator, antioxidant, and vasodilator, has been increasingly reported to be highly efficient in calciphylaxis, leading to significantly lower mortality rates. Knowledge of advancement in the treatment of calciphylaxis, which was previously a highly fatal disease, is important for physicians and other professionals from various medical fields.

Molluscum contagiosum (MC) manifests as small, umbilicated papules caused by the molluscum contagiosum virus (MCV). The extent of clinical misdiagnosis of MC is unknown. Combined clinical, histopathological, and virological evaluation of 203 consecutive patients with clinical diagnosis of MC treated at a university hospital during a 5-year period showed the correct clinical diagnosis in 188 of 203 (92.6%) patients. All 15 clinically misdiagnosed MC lesions were histopathologically and virologically confirmed as either common or anogenital warts caused by different human papillomaviruses. The MCV1/MCV2 subtypes ratio was 1.54:1, and the distribution of MCV subtypes differed across patients’ age and anatomical location of lesions.

Autoimmune diseases may also be reflected in changes in the oral cavity that represent the first sign of the disease, or they may occur simultaneously with or later in the course of the disease. Oral findings are mostly non-specific, and therefore further investigations are needed to exclude or confirm possible diagnoses. This article presents the most important diseases in this research area, divides them into meaningful groups, and highlights the importance of examining the oral cavity for possible manifestations.

Introduction Data on the effectiveness of biologics in the treatment of nail and scalp psoriasis (PSO) in a routine clinical setting are scarce. The aim of this study was therefore to evaluate the effectiveness of adalimumab in the treatment of nail and scalp psoriatic lesions in routine dermatologic practice. Methods Five hundred one patients were analyzed in this observational study; 157 patients had nail involvement (nail PSO set; NPS) and 404 had scalp involvement (scalp PSO set; SPS). Patients treated with adalimumab were observed for up to 12 months. Outcomes were evaluated via changes in the Nail Psoriasis Severity Index (NAPSI), Psoriasis Scalp Severity Index (PSSI), Psoriasis Area and Severity Index (PASI), and QoL (using the Dermatology Life Quality Index). Results Eighty-four percent of the patients in the NPS and 93.8% in the SPS achieved a good clinical response upon treatment with adalimumab. Complete clearing of local symptoms was achieved by 33.3% of the patients with nail involvement and 66.7% of the patients with scalp involvement. There was also a marked improvement in QoL. Conclusion Adalimumab appears to be an effective treatment for scalp and nail PSO in patients with moderate to severe plaque PSO. No new clinical concerns were established.

Acta Dermatovenerologica Alpina, Pannonica et Adriatica (Acta Dermatovenerol APA) is the leading journal in dermatology and sexually transmitted infections in the region. Several important steps were taken during the last 25 years to improve the journal's quality, global visibility, and international impact. After a 1-year trial period, Thomson Reuters recently informed the editorial office that they had accepted Acta Dermatovenerol APA for coverage in Thomson Reuters' new index in the Web of Science Core Collection called the Emerging Sources Citation Index (ESCI). The coverage of Acta Dermatovenerol APA begins with the journal content published online in 2016; that is, from volume 25 onwards.

Molluscum contagiosum virus (MCV) is a common skin pathogen in both adults and children. In this prospective study, we clinically evaluated consecutive patients with molluscum contagiosum (MC) who had been examined during a 5-year period at the second-largest dermatology clinic in Slovenia and described their main demographic and clinical characteristics, concomitant diseases, and treatment success. The study included 188 patients, of which 121 (64%) were men and 67 (36%) were women. A total of 135 (72%) patients were adults, with lesions that were most commonly located in the anogenital region (98%) and were probably sexually acquired. Two adult patients were diagnosed with concurrent human immunodeficiency virus (HIV) infection. Fifty-three (28%) patients were children with a mean age of 5.7 years, most commonly presenting with lesions on the torso and extremities (85%). In adults, the infection most commonly occurred in male patients, while in children it was slightly more common in female patients. At presentation, 58% of patients had more than 5 MC lesions. A total of 30% of the included children had concomitant atopic dermatitis. We did not observe an increased occurrence of MCV infection in patients with atopic dermatitis. All patients were treated with curettage of the lesions. The cure rate at the first follow-up visit after 2 months was relatively high (63%), and recurrences were not associated with the number or site of lesions at presentation or with concomitant atopic dermatitis.

Mentoring is a very effective way of transmitting professional wisdom that is under-utilized in our organizations. With this work we tried to point out the importance of mentoring in organizations, research opinion of the employee about mentoring programes that is implemented in organizations, as well as some factors that influence on their opinion. This paper analyzes some conditions tjat should be met in order to optimize the effect of mentoring relationships.

Background Darier disease (DD) is an autosomal dominant genodermatosis caused by mutations in the ATP2A2 gene. It has been reported that depletion of Ca 2+ stores within the endoplasmic reticulum of keratinocytes is associated with impaired cell cycle regulation and terminal differentiation. Mechanical stress, heat, or UV irradiation might delay cell cycle exit and permit progression into the quiescent stage without repair. When there is associated DNA damage, this can lead to an accumulation of secondary somatic mutations and possible clonal proliferation of damaged keratinocyes within keratotic papules and plaques. Objective We sought to present clinical, demographic, and genetic analysis of the cohort of Slovenian patients with DD, which represents 52% of DD patients in the country. Methods We examined 28 Slovenians with DD and screened genomic DNA for ATP2A2 mutations and RNA for splice site mutations. Results The estimated prevalence of the disease in Slovenia is 2.7/100.000. We identified 7 different ATP2A2 mutations, 4 of which are novel: A516P, R559G, 463-6del6, and 1762-6del18. We also found two previously described polymorphisms in intron XVIII (2741 + 54 G>A) and in exon 15 (2172 G>A; A724A), with allele frequencies of 64.15% and 11.32%, respectively. There was a history of perceptive deafness in two DD patients from two families. Limitations Analysis of SERCA2 expression, measurements of Ca 2+ uptake and their influence on desmosomal assembly in vitro would add additional value to the study. Although single-stranded conformational analysis (SSCP) is a common and accepted method for screening for the presence of mutations, it does miss 10% to 20% of mutations. Conclusions We identified 4 novel ATP2A2 mutations in Slovenian patients with DD. Deafness seems to be a new phenotypic characteristic of DD patients.

The paper considers different aspects of adult education institution management. Adult education institution is viewed in context of its position in the Educational system, and variable and constantly changing environment, which demands continuing adaptations and lifelong learning. In such situation, the paper considers various options of adult education institution management and proposes a model that should take into account multidimensionality of the studied phenomena. The problem is approached in an interdisciplinary manner, from the positions of educational sciences and disciplinary management.

Insulin lipoatrophy is a rare immunologic cutaneous complication in diabetes mellitus that presents with localized subcutaneous fat atrophy at the insulin injection site. We report the case of a 62-year-old woman with type 2 diabetes mellitus that developed localized lipoatrophy on the abdomen after 6 years of therapy with the insulin analogues detemir and aspart.

BACKGROUND: Previous studies carried out in Slovenia revealed a high frequency of cases of hereditary diffuse palmoplantar keratodermas (DPPK). The relatively small total population of about two million in a small territory and an efficient public health service were favorable preconditions for such a study. METHODS: Existing hospital and outpatient department records served as starting points. Patients were invited to come for a follow-up examination, and visiting the patients at their homes enabled us to gather further data. Thus efforts were made to include all patients with hereditary DPPK in Slovenia. RESULTS: Altogether 170 DPPK patients were detected, giving a prevalence of 8.3 per 100,000 inhabitants. The patients originated from remote, mostly mountainous districts, where the local DPPK prevalence highly significantly exceeded the average Slovene prevalence. The segregation ratio showed an autosomal dominant mode of inheritance. The percentage of persons affected was 34.4% (95% confidence interval 29.8–39.4), lower than expected for autosomal dominant inheritance (the difference is highly significant, P < 0.00001; exact binomial test). CONCLUSION: One autosomal dominant gene alone does not fully explain the transmission of the disorder to siblings. Evidence is produced that additional factors are necessary for the transmission of this genetic condition. The degree of consanguinity and the physical pressure on palms and soles seem to play an important part. It is reasonable to expect that molecular-biology studies linked to the epidemiological data could contribute to the solution of the problem.

Post-steroid panniculitis is an extremely rare phenomenon caused by inappropriate interruption of long-term systemic corticosteroid therapy. It usually occurs in children and is characterized by development of multiple subcutaneous nodules on the cheeks, arms, and trunk. Histologically it is a lobular type of panniculitis with characteristic needle-shaped clefts within adipocytes and numerous foreign-body giant cells. We present a case of post-steroid panniculitis occurring in a 50-year-old female after long-term administration of oral corticosteroids for Sjögren's syndrome accompanied by leukocytoclastic vasculitis and chronic polyarthritis.

Darier disease (DD) is caused by mutations of the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca2+-ATPase isoform 2 (SERCA2). The mutations affect protein expression, degradation and activity. We report a patient with severe sporadic DD, who did not respond adequately to repeated courses of orally administered acitretin and isotretinoin. He was found to harbor the missense P160L mutation of the ATP2A2 gene in a heterozygous state in the A domain of SERCA2 and polymorphism in intron 18 (2741 + 54 G → A). The A domain plays a key role in translocation of Ca2+ from cytoplasm to endoplasmic reticulum lumen, thus establishing a low intracellular Ca2+ concentration.

A 38-year-old female presented with a history of recurrent multiple deep dermal nodules located on the dorsa of the feet, over the ankle joints and lower pretibial area. Laboratory investigation excluded rheumatoid arthritis. Histopathological examination showed changes in the deep dermis: histiocytes in palisades around foci consisting of degenerated bundles of collagen, mucin, fibrin and "nuclear dust". The diagnosis of subcutaneous granuloma annulare was made on the basis of the clinical and histological features. Treatment with dapsone was successful, and in the course of two months the nodules disappeared.

The term lymphedema refers to a chronic, progressive edema, usually of a limb, due to insufficient lymphatic flow. It may appear as a primary disturbance or secondary to other causes, e.g., after infections or surgery. The most common cause of lymphedema in the Western world is cancer surgery and/or radiotherapy. The authors summarize the etiology, pathophysiology and clinical staging of lymphedema. The diagnosis of lymphedema is usually based on history and clinical appearance. However, lymphoscintigraphy is the gold standard of imaging in doubtful cases. Adequate and early compression therapy and good patient compliance are the cornerstones of management of lymphedema. The authors present their experience with compression therapy for lymphedema. While no differences were found in the efficiency of compression therapy between oncologic and non-oncologic patients, compression stockings of class III seemed to be efficient in the majority of secondary lower limb lymphedemas but not as maintenance therapy for primary lower limb lymphedema.

Hereditary palmoplantar keratodermas (HPPK) are relatively frequent in Slovenia; however, the papulosa type of HPPK is rare. Epidemiological data are scarce; a population study in Croatia revealed a prevalence of 1.17/100,000 inhabitants. According to the preliminary data, it seems that HPPK papulosa is more common in Slovenia than in other countries. Efforts were made to identify all patients with HPPK papulosa in Slovenia.Existing hospital and outpatient records served as a starting point. Patients and their relatives were invited for examination. When necessary for preparing pedigrees, we visited patients.Altogether 66 patients were observed, giving a prevalence of 3.3/100,000 inhabitants. 62 patients belonged to 11 unrelated families with two or more affected members and there were also four isolated cases. Our investigation points to an autosomal dominant mode of inheritance. All of the routine biochemical and hematologic tests were within normal limits. No malignancies were observed, nor were such data revealed in patients' histories. Thickened nail-plates were observed in three patients.The prevalence of HPPK papulosa in Slovenia is higher than in other countries studied. Further loci mentioned in literature suggest a genetic heterogeneity in this condition.

U radu se na osnovu rezultata empirijskog istraživanja ukazuje na značaj percepcije lokusa kontrole sopstvenog položaja zaposlenog u organizaciji za andragošku teoriju i praksu. Navedena pojava, u zavisnosti od percepcije, deluje kao motivator ili barijera obrazovanju zaposlenih, uslovljavajući intenzitet, vrstu i obim obrazovnih aktivnosti zaposlenih. . This paper, based on empirical research results, tries to indicate on importance of control locus perception of employee's position in organization for andragogical theory and practice. These phenomenon, depending of perception, act as a motivator or obstacle of employee's education, stipulate intensity, category and extent of employee's educational activity. .

Mycobacterium marinum is a human opportunistic pathogen that is known to inhabit swimming pools, home aquariums, and natural bodies of salt and fresh water. Epidemic cases involving swimming pools are easily recognized, but sporadic cases are frequently misdiagnosed.A 42-year-old male presented with a 2-month history of the appearance of livid, verrucous, painless nodules on his right upper extremity. He had cleaned an aquarium with tropical fish for the past 2 years.A histopathological examination suggested a granulomatous inflammation. After incubation on Löwenstein-Jensen medium, Mycobacterium marinum was identified using biochemical methods and the PCR technique.Systemic therapy with rifampicin, ethambutol, and clarithromycin over a period of 6 months led to complete resolution of the skin lesions with some residual scars.Knowledge of this condition is very important to avoid unnecessary diagnostic procedures and improper treatment.

We present the case of a 10-year-old girl with a six months history of disseminated asymptomatic, brown pigmented macules on the trunk and proximal parts of the extremities. The clinical picture, histological findings, and the course of disease were similar to those of idiopathic eruptive macular pigmentation. The cutaneous lesions gradually disappeared over the next two years without any treatment, and no relapse occurred. The knowledge of this disease is important in order to avoid unnecessary treatment as spontaneous resolution of the lesions may be expected within months or a few years. The spontaneous regression without any treatment is an additional diagnostic criterion.

A 74-year-old man presented with a five-month history of highly pruritic keratotic papules on the trunk and extremities. Laboratory data revealed mild eosinophilia, elevated IgE (483KE/I) and no other signs of atopy. Tests to exclude parasitic infestation were negative. Two biopsies showed non-specific changes. The third biopsy revealed small acantholytic clefts in the upper part of the epidermis and confirmed the diagnosis of Grover's disease. Topical treatment with calcipotriol ointment and systemic treatment with acitretin in low doses successfully reduced the pruritus within one week, and brought about a complete remission within three weeks without any recurrence.

An 82-year-old female presented with an 11-year history of multiple, symmetrically disseminated hyperkeratotic red-brown papules 3-5 mm in diameter on the dorsal aspects of the upper and lower extremities. The eruption first appeared on the dorsa of the feet and on the lower parts of the legs. During the last few years, the lesions extended gradually to the upper part of the legs and thighs, also disseminating over the trunk. There was no family case history of Flegel's disease. Histopathological examination revealed a hyperkeratosis with a focal parakeratosis overlying the thinned epidermis. In the papillary dermis there was a dense band-like infiltrate composed of lymphocytes and some histiocytes. Electron microscopy showed a normal number of membrane-coated granules (Odland bodies). The clinical and histopathological findings in the patient corresponded with the diagnosis of hyperkeratosis lenticularis perstans. The patient was treated with PUVA (psoralen plus ultraviolet A)-bath therapy, retinoid plus PUVA and calcipotriol. However, all of these treatments were unsuccessful.

Darier disease (DD) is caused by mutations of the ATP2A2 gene, which encodes the sarco/endoplasmic reticulum Ca(2+)-ATPase isoform 2 (SERCA2). The mutations affect protein expression, degradation and activity. We report a patient with severe sporadic DD, who did not respond adequately to repeated courses of orally administered acitretin and isotretinoin. He was found to harbor the missense P160L mutation of the ATP2A2 gene in a heterozygous state in the A domain of SERCA2 and polymorphism in intron 18 (2741 + 54 G --A). The A domain plays a key role in translocation of Ca(2+) from cytoplasm to endoplasmic reticulum lumen, thus establishing a low intracellular Ca(2+) concentration.