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473 results on '"KWAN, JENNIFER"'

1. Assessment of Clonal Hematopoiesis of Indeterminate Potential from Cardiac Magnetic Resonance Imaging using Deep Learning in a Cardio-oncology Population

Author

Ryu, Sangeon, Ahn, Shawn, Espinoza, Jeacy, Jha, Alokkumar, Halene, Stephanie, Duncan, James S., Kwan, Jennifer M, and Dvornek, Nicha C.

Subjects
Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Background: We propose a novel method to identify who may likely have clonal hematopoiesis of indeterminate potential (CHIP), a condition characterized by the presence of somatic mutations in hematopoietic stem cells without detectable hematologic malignancy, using deep learning techniques. Methods: We developed a convolutional neural network (CNN) to predict CHIP status using 4 different views from standard delayed gadolinium-enhanced cardiac magnetic resonance imaging (CMR). We used 5-fold cross validation on 82 cardio-oncology patients to assess the performance of our model. Different algorithms were compared to find the optimal patient-level prediction method using the image-level CNN predictions. Results: We found that the best model had an area under the receiver operating characteristic curve of 0.85 and an accuracy of 82%. Conclusions: We conclude that a deep learning-based diagnostic approach for CHIP using CMR is promising.

Published
2024

5. Clinical Outcomes Among Immunotherapy-Treated Patients With Primary Cardiac Soft Tissue Sarcomas: A Multicenter Retrospective Study

Author

Nassar, Amin H., El-Am, Edward, Denu, Ryan, Abou Alaiwi, Sarah, El Zarif, Talal, Macaron, Walid, Abdel-Wahab, Noha, Desai, Aakash, Smith, Caleb, Parikh, Kaushal, Abbasi, Muhannad, Bou Farhat, Elias, Williams, James M., Collins, Jeremy D., Al-Hader, Ahmad, McKay, Rana R., Malvar, Carmel, Sabra, Mohamad, Zhong, Caiwei, El Alam, Raquelle, Chehab, Omar, Lima, Joao, Phan, Minh, Dalla Pria, Hanna Ferreira, Trevino, Alexandra, Neilan, Tomas G., Kwan, Jennifer M., Ravi, Vinod, Deshpande, Hari, Demetri, George, Choueiri, Toni K., and Naqash, Abdul Rafeh

Published
2024
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8. Abstract 17610: A Novel Approach Using Deep Neural Networks on Clinical Cardiac MRIs Can Identify Patients With Clonal Hematopoiesis of Indeterminate Potential With High Accuracy

Author

Ryu, Allen, Christofides, Anthos, Matute Martinez, Carlos, Jayakrishnan, Ritujith, Ahn, Shawn, Ferrigno Guajardo, Ana, Espinoza, Jeacy, Chen, Nathan, Jha, Alokkumar, Im, Yunju, Halene, Stephanie, VanOudenhove, Jennifer, MOJIBIAN, HAMID, Duncan, James, Dvornek, Nicha, and Kwan, Jennifer M

Published
2023
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11. Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial

Author

Sagara, Issaka, Healy, Sara A, Assadou, Mahamadoun H, Kone, Mamady, Swihart, Bruce J, Kwan, Jennifer L, Fintzi, Jonathan, Sissoko, Kourane, Kamate, Bourama, Samake, Yacouba, Guindo, Merepen A, Doucoure, M'Bouye, Niaré, Karamoko, Dolo, Amagana, Diarra, Balla, Rausch, Kelly M, Narum, David L, Jones, David S, MacDonald, Nicholas J, Zhu, Daming, Gorres, J Patrick, Imeru, Alemush, Mohan, Rathy, Thera, Ismaila, Zaidi, Irfan, Salazar-Miralles, Fernando, Duan, Junhui, Neal, Jillian, Morrison, Robert D, Muratova, Olga, Sylla, Daman, O'Connell, Elise M, Wu, Yimin, Hume, Jen C C, Coulibaly, Mamadou B, Anderson, Charles F, Traore, Sekou F, Doumbo, Ogobara K, and Duffy, Patrick E

Published
2023
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12. IFN-λ4 is associated with increased risk and earlier occurrence of several common infections in African children

Author

Prokunina-Olsson, Ludmila, Morrison, Robert D, Obajemu, Adeola, Mahamar, Almahamoudou, Kim, Sungduk, Attaher, Oumar, Florez-Vargas, Oscar, Sidibe, Youssoufa, Onabajo, Olusegun O, Hutchinson, Amy A, Manning, Michelle, Kwan, Jennifer, Brand, Nathan, Dicko, Alassane, Fried, Michal, Albert, Paul S, Mbulaiteye, Sam M, and Duffy, Patrick E

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Clinical Research, Prevention, Pediatric, Genetics, Digestive Diseases, Infection, Good Health and Well Being, Alleles, Child, Genotype, Hepacivirus, Hepatitis C, Humans, Interferons, Interleukins, Polymorphism, Single Nucleotide, Immunology
Abstract

Genetic polymorphisms within the IFNL3/IFNL4 genomic region, which encodes type III interferons, have been strongly associated with clearance of hepatitis C virus. We hypothesized that type III interferons might be important for the immune response to other pathogens as well. In a cohort of 914 Malian children, we genotyped functional variants IFNL4-rs368234815, IFNL4-rs117648444, and IFNL3-rs4803217 and analyzed episodes of malaria, gastrointestinal, and respiratory infections recorded at 30,626 clinic visits from birth up to 5 years of age. Compared to children with the rs368234815-TT/TT genotype (IFN-λ4-Null), rs368234815-dG allele was most strongly associated with an earlier time-to-first episode of gastrointestinal infections (p = 0.003). The risk of experiencing an infection episode during the follow-up was also significantly increased with rs368234815-dG allele, with OR = 1.53, 95%CI (1.13-2.07), p = 0.005 for gastrointestinal infections and OR = 1.30, 95%CI (1.02-1.65), p = 0.033 for malaria. All the associations for the moderately linked rs4803217 (r2 = 0.78 in this set) were weaker and lost significance after adjusting for rs368234815. We also analyzed all outcomes in relation to IFN-λ4-P70S groups. Our results implicate IFN-λ4 and not IFN-λ3 as the primary functional cause of genetic associations with increased overall risk and younger age at first clinical episodes but not with recurrence or intensity of several common pediatric infections.

Published
2021

14. Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement

Author

Vidula, Mahesh K., Rajewska-Tabor, Justyna, Cao, J. Jane, Kang, Yu, Craft, Jason, Mei, Winifred, Chandrasekaran, Preethi S., Clark, Daniel E., Poenar, Ana-Maria, Gorecka, Miroslawa, Malahfji, Maan, Cowan, Eilidh, Kwan, Jennifer M., Reinhardt, Samuel W., Al-Tabatabaee, Sarah, Doeblin, Patrick, Villa, Adriana D.M., Karagodin, Ilya, Alvi, Nazia, Christia, Panagiota, Spetko, Nicholas, Cassar, Mark Philip, Park, Christine, Nambiar, Lakshmi, Turgut, Alper, Azad, Mahan Roosta, Lambers, Moritz, Wong, Timothy C., Salerno, Michael, Kim, Jiwon, Elliott, Michael, Raman, Betty, Neubauer, Stefan, Tsao, Connie W., LaRocca, Gina, Patel, Amit R., Chiribiri, Amedeo, Kelle, Sebastian, Baldassarre, Lauren A., Shah, Dipan J., Hughes, Sean G., Tong, Matthew S., Pyda, Malgorzata, Simonetti, Orlando P., Plein, Sven, and Han, Yuchi

Published
2023
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17. Clinical Biochemistry of Serum Troponin

Author

Gokhan, Ilhan, primary, Dong, Weilai, additional, Grubman, Daniel, additional, Mezue, Kenechukwu, additional, Yang, David, additional, Wang, Yanting, additional, Gandhi, Parul U., additional, Kwan, Jennifer M., additional, and Hu, Jiun-Ruey, additional

Published
2024
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24. Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma.

Author

Abdalla, Moustafa, Tran-Thanh, Danh, Moreno, Juan, Iakovlev, Vladimir, Nair, Ranju, Kanwar, Nisha, Abdalla, Mohamed, Lee, Jennifer PY, Kwan, Jennifer Yin Yee, Cawthorn, Thomas R, Warren, Keisha, Arneson, Nona, Wang, Dong-Yu, Fox, Natalie S, Youngson, Bruce J, Miller, Naomi A, Easson, Alexandra M, McCready, David, Leong, Wey L, Boutros, Paul C, and Done, Susan J

Subjects
Epithelial Cells, Humans, Carcinoma, Ductal, Breast, Breast Neoplasms, RNA-Binding Proteins, Cell Cycle Proteins, RNA, Messenger, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Genomics, Mutation, Genome, Human, Female, Comparative Genomic Hybridization, Neoplasm Grading, Transcriptome, MCF-7 Cells, Carcinoma, Ductal, Breast, Genome, Human, RNA, Messenger
Abstract

Almost all genomic studies of breast cancer have focused on well-established tumours because it is technically challenging to study the earliest mutational events occurring in human breast epithelial cells. To address this we created a unique dataset of epithelial samples ductoscopically obtained from ducts leading to breast carcinomas and matched samples from ducts on the opposite side of the nipple. Here, we demonstrate that perturbations in mRNA abundance, with increasing proximity to tumour, cannot be explained by copy number aberrations. Rather, we find a possibility of field cancerization surrounding the primary tumour by constructing a classifier that evaluates where epithelial samples were obtained relative to a tumour (cross-validated micro-averaged AUC = 0.74). We implement a spectral co-clustering algorithm to define biclusters. Relating to over-represented bicluster pathways, we further validate two genes with tissue microarrays and in vitro experiments. We highlight evidence suggesting that bicluster perturbation occurs early in tumour development.

Published
2017

25. Prospective Evaluation of Immune Checkpoint Inhibitor Myocarditis with Serial Quantitative Cardiovascular Magnetic Resonance and Correlations with Cardiovascular Outcomes

Author

Khattab, Mohamad, primary, Kwan, Jennifer, additional, Chehayeb, Rachel Jaber, additional, Guajardo, Ana Ferrigno, additional, Lin, Derrick, additional, Christophides, Anthos, additional, Alkhatib, Deya, additional, Martinez, Carlos Matute, additional, Shah, Nimish, additional, Im, Yunju, additional, Jeyashanmugaraja, Gini Priyadharshini, additional, Ragheb, Elio, additional, Higgins, Angela, additional, Redheiul, Alban, additional, Salem, Joe-Elie, additional, Peters, Dana, additional, Mohjibian, Hamid, additional, and Baldassarre, Lauren, additional

Published
2024
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27. Left Atrial Evaluation in Immune Check Point Inhibitor Myocarditis Using Cardiac Magnetic Resonance Imaging and Correlations with Cardiovascular Outcomes

Author

Jeyashanmugaraja, Gini Priyadharshini, primary, Kwan, Jennifer, additional, Shah, Nimish, additional, Lamy, Jerome, additional, Khattab, Mohamad, additional, Chehayeb, Rachel Jaber, additional, Guajardo, Ana Ferrigno, additional, Lin, Derrick, additional, Christofides, Anthos, additional, Alkhatib, Deya, additional, Martinez, Carlos Matute, additional, Im, Yunju, additional, Salem, Joe-Elie, additional, Redheuil, Alban, additional, Peters, Dana, additional, and Baldassarre, Lauren, additional

Published
2024
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31. The impact of SARS-CoV-2 variants on the likelihood of children identified as sources of infection in the NIH workforce: a cohort study

Author

van Loben Sels, Jessica M, primary, Bailin, Heike B, additional, Bell, Michael R, additional, McCormick-Ell, Jessica, additional, McGann, Michael, additional, Das, Sanchita, additional, Roder, Allison E, additional, Ghedin, Elodie, additional, Castel, Amanda D, additional, D. Rebecca, Prevots, additional, and Kwan, Jennifer L, additional

Published
2023
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33. A neutrophil activation signature predicts critical illness and mortality in COVID-19

Author

Meizlish, Matthew L., Pine, Alexander B., Bishai, Jason D., Goshua, George, Nadelmann, Emily R., Simonov, Michael, Chang, C-Hong, Zhang, Hanming, Shallow, Marcus, Bahel, Parveen, Owusu, Kent, Yamamoto, Yu, Arora, Tanima, Atri, Deepak S., Patel, Amisha, Gbyli, Rana, Kwan, Jennifer, Won, Christine H., Dela Cruz, Charles, Price, Christina, Koff, Jonathan, King, Brett A., Rinder, Henry M., Wilson, F. Perry, Hwa, John, Halene, Stephanie, Damsky, William, van Dijk, David, Lee, Alfred I., and Chun, Hyung J.

Published
2021
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35. Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing.

Author

Maayah, Marah, Grubman, Scott, Allen, Stephanie, Ye, Zachary, Park, Dae Yong, Vemmou, Evangelia, Gokhan, Ilhan, Sun, Wendy W., Possick, Stephen, Kwan, Jennifer M., Gandhi, Parul U., and Hu, Jiun-Ruey

Subjects
ACUTE coronary syndrome, MYOCARDIAL injury, TROPONIN, MYOCARDIAL ischemia, PROGNOSIS, MYOCARDIAL infarction, BRUGADA syndrome
Abstract

Cardiac troponin (Tn) plays a central role in the evaluation of patients with angina presenting with acute coronary syndrome. The advent of high-sensitivity assays has improved the analytic sensitivity and precision of serum Tn measurement, but this advancement has come at the cost of poorer specificity. The role of clinical judgment is of heightened importance because, more so than ever, the interpretation of serum Tn elevation hinges on the careful integration of findings from electrocardiographic, echocardiographic, physical exam, interview, and other imaging and laboratory data to formulate a weighted differential diagnosis. A thorough understanding of the epidemiology, mechanisms, and prognostic implications of Tn elevations in each cardiac and non-cardiac etiology allows the clinician to better distinguish between presentations of myocardial ischemia and myocardial injury—an important discernment to make, as the treatment of acute coronary syndrome is vastly different from the workup and management of myocardial injury and should be directed at the underlying cause. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Artemisinin-Resistant Malaria as a Global Catastrophic Biological Threat

Author

Ricotta, Emily, Kwan, Jennifer, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W, Series Editor, Galan, Jorge E, Series Editor, Garcia-Sastre, Adolfo, Series Editor, Malissen, Bernard, Series Editor, Rappuoli, Rino, Series Editor, Inglesby, Thomas V., editor, and Adalja, Amesh A., editor

Published
2019
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37. A new classification of cardio-oncology syndromes

Author

de Boer, Rudolf A., Aboumsallem, Joseph Pierre, Bracun, Valentina, Leedy, Douglas, Cheng, Richard, Patel, Sahishnu, Rayan, David, Zaharova, Svetlana, Rymer, Jennifer, Kwan, Jennifer M., Levenson, Joshua, Ronco, Claudio, Thavendiranathan, Paaladinesh, and Brown, Sherry-Ann

Published
2021
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47. Radiomic Biomarkers to Refine Risk Models for Distant Metastasis in HPV-related Oropharyngeal Carcinoma

Author

Kwan, Jennifer Yin Yee, Su, Jie, Huang, Shao Hui, Ghoraie, Laleh S., Xu, Wei, Chan, Biu, Yip, Kenneth W., Giuliani, Meredith, Bayley, Andrew, Kim, John, Hope, Andrew J., Ringash, Jolie, Cho, John, McNiven, Andrea, Hansen, Aaron, Goldstein, David, de Almeida, John R., Aerts, Hugo J., Waldron, John N., Haibe-Kains, Benjamin, O'Sullivan, Brian, Bratman, Scott V., and Liu, Fei-Fei

Published
2018
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48. Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer‐associated variants

Author

Peltekova, Vanya D, Lemire, Mathieu, Qazi, Aamer M, Zaidi, Syed HE, Trinh, Quang M, Bielecki, Ryszard, Rogers, Marianne, Hodgson, Lyndsey, Wang, Mike, D’Souza, David JA, Zandi, Sasan, Chong, Taryne, Kwan, Jennifer YY, Kozak, Krystian, De Borja, Richard, Timms, Lee, Rangrej, Jagadish, Volar, Milica, Chan-Seng-Yue, Michelle, Beck, Timothy, Ash, Colleen, Lee, Shawna, Wang, Jianxin, Boutros, Paul C, Stein, Lincoln D, Dick, John E, Gryfe, Robert, McPherson, John D, Zanke, Brent W, Pollett, Aaron, Gallinger, Steven, and Hudson, Thomas J

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Genetics, Colo-Rectal Cancer, Biotechnology, Cancer, Digestive Diseases, Human Genome, Aetiology, 2.1 Biological and endogenous factors, Inflammatory and immune system, Amino Acid Sequence, Blotting, Western, Caco-2 Cells, Cell Line, Tumor, Colon, Colorectal Neoplasms, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, HCT116 Cells, HEK293 Cells, HL-60 Cells, HT29 Cells, HeLa Cells, Humans, Immune System, Immunohistochemistry, Jurkat Cells, K562 Cells, MCF-7 Cells, Molecular Sequence Data, Neoplasm Proteins, Phylogeny, Polymorphism, Single Nucleotide, RNA, Reverse Transcriptase Polymerase Chain Reaction, Sequence Homology, Amino Acid, U937 Cells, genome-wide association study, genetic risk factors, colon cancer, tumor microenvironment, Hela Cells, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

A locus on human chromosome 11q23 tagged by marker rs3802842 was associated with colorectal cancer (CRC) in a genome-wide association study; this finding has been replicated in case-control studies worldwide. In order to identify biologic factors at this locus that are related to the etiopathology of CRC, we used microarray-based target selection methods, coupled to next-generation sequencing, to study 103 kb at the 11q23 locus. We genotyped 369 putative variants from 1,030 patients with CRC (cases) and 1,061 individuals without CRC (controls) from the Ontario Familial Colorectal Cancer Registry. Two previously uncharacterized genes, COLCA1 and COLCA2, were found to be co-regulated genes that are transcribed from opposite strands. Expression levels of COLCA1 and COLCA2 transcripts correlate with rs3802842 genotypes. In colon tissues, COLCA1 co-localizes with crystalloid granules of eosinophils and granular organelles of mast cells, neutrophils, macrophages, dendritic cells and differentiated myeloid-derived cell lines. COLCA2 is present in the cytoplasm of normal epithelial, immune and other cell lineages, as well as tumor cells. Tissue microarray analysis demonstrates the association of rs3802842 with lymphocyte density in the lamina propria (p = 0.014) and levels of COLCA1 in the lamina propria (p = 0.00016) and COLCA2 (tumor cells, p = 0.0041 and lamina propria, p = 6 × 10(-5)). In conclusion, genetic, expression and immunohistochemical data implicate COLCA1 and COLCA2 in the pathogenesis of colon cancer. Histologic analyses indicate the involvement of immune pathways.

Published
2014

50. Owner Attachment and Problem Behaviors Related to Relinquishment and Training Techniques of Dogs

Author

Kwan, Jennifer Y and Bain, Melissa J

Subjects
Basic Behavioral and Social Science, Behavioral and Social Science, Adult, Animals, Behavior, Animal, Dogs, Female, Human-Animal Bond, Humans, Male, Middle Aged, Ownership, Surveys and Questionnaires, Young Adult, dog, behavior, shelter, attachment, Zoology, Animal Production, Veterinary Sciences, Behavioral Science & Comparative Psychology
Abstract

Problematic behaviors are a significant reason for relinquishment, and relinquished dogs are more likely to have problem behaviors. This study utilized standardized surveys of owners (companion animal guardians) relinquishing their dogs to shelters and dog owners visiting vaccination clinics. "Relinquishing" and "continuing" owners were asked questions in the following categories: demographic information, training methods and tools, frequencies in which their dogs engaged in problematic behaviors, and attachment to their dogs. "Relinquishers" were also asked to provide their reasons for relinquishment. The results of 129 surveys (80 relinquishing and 49 continuing) showed that relinquishers scored lower on companion animal attachment than continuing owners. Pit bull-type dogs were represented more in the relinquishing group. Relinquished dogs were no less likely to have attended training classes than continuing dogs. In both groups, owners who used punishment-based collars reported less satisfaction with their dogs' overall and leash-walking behaviors. Pit bull-type dogs were reported to be no less well behaved compared with all other breeds combined. Sixty-five percent of relinquishers reported some behavioral reason for relinquishment. Forty-eight percent of relinquishers indicated that at least 1 problem behavior was a strong influence on their decision to relinquish.

Published
2013

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