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3,030 results on '"Knapp, M"'

2. Radio Observations of HD80606 Near Planetary Periastron: II. LOFAR Low Band Antenna Observations at 30-78 MHz

Author

de Gasperin, F., Lazio, T. J. W., and Knapp, M.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

All the giant planets in the solar system generate radio emission via the electron cyclotron maser instability, most notably giving rise to Jupiter's decametric emissions. An interaction with the solar wind is at least partially responsible for all of these solar system electron cyclotron masers. HD80606b is a giant planet with a highly eccentric orbit, leading to predictions that its radio emission may be enhanced substantially near periastron. This paper reports observations with the Low Frequency Array (LOFAR) of HD80606b near its periastron in an effort to detect radio emissions generated by an electron cyclotron maser instability in the planet's magnetosphere. The reported observations are at frequencies between 30 MHz and 78 MHz, and they are distinguished from most previous radio observations of extrasolar planets by two factors: (i) They are at frequencies near 50 MHz, much closer to the frequencies at which Jupiter emits (< 40 MHz) and lower than most previously reported observations of extrasolar planets; and (ii) Sensitivities of approximately a few millijanskys have been achieved, an order of magnitude or more below nearly all previous extrasolar planet observations below 100 MHz. We do not detect any radio emissions from HD80606b and use these observations to place new constraints on its radio luminosity. We also revisit whether the observations were conducted at a time when it was super-Alfvenic relative to the host star's stellar wind, which experience from the solar system illustrates is a state in which an electron cyclotron maser emission can be sustained in a planet's magnetic polar regions., Comment: 7 pages, 2 figures, accepted A&A

Published
2020
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4. Magnetic Fields of Extrasolar Planets: Planetary Interiors and Habitability

Author

Lazio, J., Hallinan, G., Airapetian, V., Brain, D. A., Dong, C. F., Driscoll, P. E., Griessmeier, J. -M., Farrell, W. M., Kasper, J. C., Murphy, T., Rogers, L. A., Wolszczan, A., Zarka, P., Knapp, M., Lynch, C. R., and Turner, J. D.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Jupiter's radio emission has been linked to its planetary-scale magnetic field, and spacecraft investigations have revealed that most planets, and some moons, have or had a global magnetic field. Generated by internal dynamos, magnetic fields are one of the few remote sensing means of constraining the properties of planetary interiors. For the Earth, its magnetic field has been speculated to be partially responsible for its habitability, and knowledge of an extrasolar planet's magnetic field may be necessary to assess its habitability. The radio emission from Jupiter and other solar system planets is produced by an electron cyclotron maser, and detections of extrasolar planetary electron cyclotron masers will enable measurements of extrasolar planetary magnetic fields. This white paper draws heavily on the W. M. Keck Institute for Space Studies report Planetary Magnetic Fields: Planetary Interiors and Habitability (Lazio, Shkolnik, Hallinan, et al.), it incorporates topics discussed at the American Astronomical Society Topical Conference "Radio Exploration of Planetary Habitability," it complements the Astrobiology Science Strategy white paper "Life Beyond the Solar System: Space Weather and Its Impact on Habitable Worlds" (Airapetian et al.), and it addresses aspects of planetary magnetic fields discussed in the NASA Astrobiology Strategy., Comment: A white paper submitted to the National Academy of Science Committee on Exoplanet Science Strategy; 6 pages

Published
2018

5. Solar Imaging using Low Frequency Arrays

Author

Lonsdale, C., Benkevitch, L., Cairns, I., Crowley, M., Erickson, P., Knapp, M., Kozarev, K., Lind, F., McCauley, P., Morgan, J., and Oberoi, D.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

Low frequency imaging radio arrays such as MWA, LWA and LOFAR have been recently commissioned, and significantly more advanced and flexible arrays are planned for the near term. These powerful instruments offer new opportunities for direct solar imaging at high time and frequency resolution. They can also probe large volumes of the heliosphere simultaneously, by virtue of very large fields of view. They allow highly detailed, spatially resolved study of solar and heliospheric radio bursts, which are complemented by heliospheric propagation studies using both background astronomical radio emissions as well as the bursts themselves. In this paper, the state of the art in such wide field solar and heliospheric radio studies is summarized, including recent results from the Murchison Widefield Array (MWA). The prospects for major advances in observational capabilities in the near future are reviewed, with particular emphasis on the RAPID system developed at Haystack Observatory, Comment: Accepted for publication in Proceedings of "8th International Workshop on Planetary, Solar and Heliospheric Radio Emissions (PRE VIII)". 10 pages, 4 figures

Published
2018

7. Flux Modulations seen by the Muon Veto of the GERDA Experiment

Author

Agostini, M., Allardt, M., Bakalyarov, A. M., Balata, M., Barabanov, I., Barros, N., Baudis, L., Bauer, C., Becerici-Schmidt, N., Bellotti, E., Belogurov, S., Belyaev, S. T., Benato, G., Bettini, A., Bezrukov, L., Bode, T., Borowicz, D., Brudanin, V., Brugnera, R., Caldwell, A., Cattadori, C., Chernogorov, A., D'Andrea, V., Demidova, E. V., di Vacri, A., Domula, A., Doroshkevich, E., Egorov, V., Falkenstein, R., Fedorova, O., Freund, K., Frodyma, N., Gangapshev, A., Garfagnini, A., Grabmayr, P., Gurentsov, V., Gusev, K., Hegai, A., Heisel, M., Hemmer, S., Hofmann, W., Hult, M., Inzhechik, L. V., Ioannucci, L., Csáthy, J. Janicskó, Jochum, J., Junker, M., Kazalov, V., Kihm, T., Kirpichnikov, I. V., Kirsch, A., Klimenko, A., Knapp, M., Knöpfle, K. T., Kochetov, O., Kornoukhov, V. N., Kuzminov, V. V., Laubenstein, M., Lazzaro, A., Lebedev, V. I., Lehnert, B., Liao, H. Y., Lindner, M., Lippi, I., Lubashevskiy, A., Lubsandorzhiev, B., Lutter, G., Macolino, C., Majorovits, B., Maneschg, W., Medinaceli, E., Misiaszek, M., Moseev, P., Nemchenok, I., Palioselitis, D., Panas, K., Pandola, L., Pelczar, K., Pullia, A., Riboldi, S., Ritter, F., Rumyantseva, N., Sada, C., Salathe, M., Schmitt, C., Schneider, B., Schönert, S., Schreiner, J., Schütz, A. -K., Schulz, O., Schwingenheuer, B., Selivanenko, O., Shevchik, E., Shirchenko, M., Simgen, H., Smolnikov, A., Stanco, L., Stepaniuk, M., Strecker, H., Vanhoefer, L., Vasenko, A. A., Veresnikova, A., vonSturm, K., Wagner, V., Walter, M., Wegmann, A., Wester, T., Wilsenach, H., Wojcik, M., Yanovich, E., Zhitnikov, I., Zhukov, S. V., Zinatulina, D., Zuber, K., and Zuzel, G.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

The GERDA experiment at LNGS of INFN is equipped with an active muon veto. The main part of the system is a water Cherenkov veto with 66~PMTs in the water tank surrounding the GERDA cryostat. The muon flux recorded by this veto shows a seasonal modulation. Two effects have been identified which are caused by secondary muons from the CNGS neutrino beam (2.2 %) and a temperature modulation of the atmosphere (1.4 %). A mean cosmic muon rate of $I^0_{\mu} = (3.477 \pm 0.002_{\textrm{stat}} \pm 0.067_{\textrm{sys}}) \times 10^{-4}$/(s$\cdot$m$^2$) was found in good agreement with other experiments at LNGS at a depth of 3500~meter water equivalent., Comment: 7 pages, 6 figures

Published
2016
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8. The Performance of the Muon Veto of the GERDA Experiment

Author

Freund, K., Falkenstein, R., Grabmayr, P., Hegai, A., Jochum, J., Knapp, M., Lubsandorzhiev, B., Ritter, F., Schmitt, C., Schütz, A. -K., Jitnikov, I., Shevchik, E., Shirchenko, M., and Zinatulina, D.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment
Abstract

Low background experiments need a suppression of cosmogenically induced events. The GERDA experiment located at LNGS is searching for the neutrinless double beta decay of $^{76}$Ge. It is equipped with an active muon veto the main part of which is a water Cherenkov veto with 66 PMTs in the watertank surrounding the GERDA cryostat. With this system 806 live days have been recorded, 491 days were combined muon-germanium data. A muon detection efficiency of $\varepsilon_{\mu d}=(99.935\pm0.015)$ \% was found in a Monte Carlo simulation for the muons depositing energy in the germanium detectors. By examining coincident muon-germanium events a rejection efficiency of $\varepsilon_{\mu r}=(99.2_{-0.4}^{+0.3})$ \% was found. Without veto condition the muons by themselves would cause a background index of $\textrm{BI}_{\mu}=(3.16 \pm 0.85)\times10^{-3}$ cts/(keV$\cdot$kg$\cdot$yr) at $Q_{\beta\beta}$., Comment: 11pages, 14 figures

Published
2016
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12. Flux modulations seen by the muon veto of the Gerda experiment

Author

collaboration, GERDA, Agostini, M, Allardt, M, Bakalyarov, AM, Balata, M, Barabanov, I, Barros, N, Baudis, L, Bauer, C, Becerici-Schmidt, N, Bellotti, E, Belogurov, S, Belyaev, ST, Benato, G, Bettini, A, Bezrukov, L, Bode, T, Borowicz, D, Brudanin, V, Brugnera, R, Caldwell, A, Cattadori, C, Chernogorov, A, D’Andrea, V, Demidova, EV, di Vacri, A, Domula, A, Doroshkevich, E, Egorov, V, Falkenstein, R, Fedorova, O, Freund, K, Frodyma, N, Gangapshev, A, Garfagnini, A, Grabmayr, P, Gurentsov, V, Gusev, K, Hegai, A, Heisel, M, Hemmer, S, Hofmann, W, Hult, M, Inzhechik, LV, Ioannucci, L, Cs’athy, J Janicsk’o, Jochum, J, Junker, M, Kazalov, V, Kihm, T, Kirpichnikov, IV, Kirsch, A, Klimenko, A, Knapp, M, Knöpfle, KT, Kochetov, O, Kornoukhov, VN, Kuzminov, VV, Laubenstein, M, Lazzaro, A, Lebedev, VI, Lehnert, B, Liao, HY, Lindner, M, Lippi, I, Lubashevskiy, A, Lubsandorzhiev, B, Lutter, G, Macolino, C, Majorovits, B, Maneschg, W, Medinaceli, E, Misiaszek, M, Moseev, P, Nemchenok, I, Palioselitis, D, Panas, K, Pandola, L, Pelczar, K, Pullia, A, Riboldi, S, Ritter, F, Rumyantseva, N, Sada, C, Salathe, M, Schmitt, C, Schneider, B, Schönert, S, Schreiner, J, Schütz, A-K, Schulz, O, Schwingenheuer, B, Selivanenko, O, Shevchik, E, Shirchenko, M, Simgen, H, Smolnikov, A, Stanco, L, Stepaniuk, M, and Strecker, H

Subjects
Water cherenkov detector, Underground experiment, Cosmic rays, Muon interaction, physics.ins-det, hep-ex, Astronomical and Space Sciences, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Nuclear & Particles Physics
Abstract

The GERDA experiment at LNGS of INFN is equipped with an active muon veto. The main part of the system is a water Cherenkov veto with 66 PMTs in the water tank surrounding the GERDA cryostat. The muon flux recorded by this veto shows a seasonal modulation. Two causes have been identified: (i) secondary muons from the CNGS neutrino beam (2.2%) and (ii) a temperature modulation of the atmosphere (1.4%). A mean cosmic muon rate of Iμ0=(3.477±0.002stat±0.067sys)×10−4/(s · m2) was found in good agreement with other experiments at LNGS. Combining the present result with those from previous experiments at LNGS the effective temperature coefficient αT,Lngs is determined to 0.93 ± 0.03. A fit of the temperature coefficients measured at various underground sites yields a kaon to pion ratio rK/π of 0.10 ± 0.03.

Published
2016

14. Safety and efficacy of inactivated varicella zoster virus vaccine in immunocompromised patients with malignancies: a two-arm, randomised, double-blind, phase 3 trial

Author

Cerana, S, Dictar, MO, Bonvehi, P, Tregnaghi, JP, Fein, L, Ashley, D, Singh, M, Hayes, T, Playford, G, Morrissey, O, Thaler, J, Kuehr, T, Greil, R, Pecherstorfer, M, Duck, L, Van Eygen, K, Aoun, M, De Prijck, B, Franke, FA, Barrios, CHE, Mendes, AVA, Serrano, SV, Garcia, RF, Moore, F, Camargo, JFC, Pires, LA, Alves, RS, Radinov, A, Oreshkov, K, Minchev, V, Hubenova, AI, Koynova, T, Ivanov, I, Rabotilova, B, Petrov, PA, Chilingirov, P, Karanikolov, S, Raynov, J, Grimard, D, McNeil, S, Kumar, D, Larratt, LM, Weiss, K, Delage, R, Diaz-Mitoma, FJ, Cano, PO, Couture, F, Carvajal, P, Yepes, A, Torres Ulloa, R, Fardella, P, Caglevic, C, Rojas, C, Orellana, E, Gonzalez, P, Acevedo, A, Galvez, KM, Gonzalez, ME, Franco, S, Restrepo, JG, Rojas, CA, Bonilla, C, Florez, LE, Ospina, AV, Manneh, R, Zorica, R, Vrdoljak, DV, Samarzija, M, Petruzelka, L, Vydra, J, Mayer, J, Cibula, D, Prausova, J, Paulson, G, Ontaneda, M, Palk, K, Vahlberg, A, Rooneem, R, Galtier, F, Postil, D, Lucht, F, Laine, F, Launay, O, Laurichesse, H, Duval, X, Cornely, OA, Camerer, B, Panse, J, Zaiss, M, Derigs, H-G, Menzel, H, Verbeek, M, Georgoulias, V, Mavroudis, D, Anagnostopoulos, A, Terpos, E, Cortes, D, Umanzor, J, Bejarano, S, Galeano, RW, Wong, RSM, Hui, P, Pedrazzoli, P, Ruggeri, L, Aversa, F, Bosi, A, Gentile, G, Rambaldi, A, Contu, A, Marei, L, Abbadi, A, Hayajneh, W, Kattan, J, Farhat, F, Chahine, G, Rutkauskiene, J, Marfil Rivera, LJ, Lopez Chuken, YA, Franco Villarreal, H, Lopez Hernandez, J, Blacklock, H, Lopez, RI, Alvarez, R, Gomez, AM, Quintana, TS, Moreno Larrea, MDC, Zorrilla, SJ, Alarcon, E, Samanez, FCA, Caguioa, PB, Tiangco, BJ, Mora, EM, Betancourt-Garcia, RD, Hallman-Navarro, D, Feliciano-Lopez, LJ, Velez-Cortes, HA, Cabanillas, F, Ganea, DE, Ciuleanu, TE, Ghizdavescu, DG, Miron, L, Cebotaru, CL, Cainap, CI, Anghel, R, Dvorkin, MV, Gladkov, OA, Fadeeva, NV, Kuzmin, AA, Lipatov, ON, Zbarskaya, II, Akhmetzyanov, FS, Litvinov, IV, Afanasyev, BV, Cherenkova, M, Lioznov, D, Lisukov, IA, Smirnova, YA, Kolomietz, S, Halawani, H, Goh, YT, Drgona, L, Chudej, J, Matejkova, M, Reckova, M, Rapoport, BL, Szpak, WM, Malan, DR, Jonas, N, Jung, CW, Lee, DG, Yoon, SS, Lopez Jimenez, J, Duran Martinez, I, Rodriguez Moreno, JF, Solano Vercet, C, de la Camara, R, Batlle Massana, M, Yeh, S-P, Chen, C-Y, Chou, H-H, Tsai, C-M, Chiu, C-H, Siritanaratkul, N, Norasetthada, L, Sriuranpong, V, Seetalarom, K, Akan, H, Dane, F, Ozcan, MA, Ozsan, GH, Kalayoglu Besisik, SF, Cagatay, A, Yalcin, S, Peniket, A, Mullan, SR, Dakhil, KM, Sivarajan, K, Suh, JJ-G, Sehgal, A, Marquez, F, Gomez, EG, Mullane, MR, Skinner, WL, Behrens, RJ, Trevarthe, DR, Mazurczak, MA, Lambiase, EA, Vidal, CA, Anac, SY, Rodrigues, GA, Baltz, B, Boccia, R, Wertheim, MS, Holladay, CS, Zenk, D, Fusselman, W, Wade III, JL, Jaslowsk, AJ, Keegan, J, Robinson, MO, Go, RS, Farnen, J, Amin, B, Jurgens, D, Risi, GF, Jr, Beatty, PG, Naqvi, T, Parshad, S, Hansen, VL, Ahmed, M, Steen, PD, Badarinath, S, Dekker, A, Scouros, MA, Young, DE, Graydon Harker, W, Kendall, SD, Citron, ML, Chedid, S, Posada, JG, Jr, Gupta, MK, Rafiyath, S, Buechler-Price, J, Sreenivasappa, S, Chay, CH, Burke, JM, Young, SE, Mahmood, A, Kugler, JW, Gerstner, G, Fuloria, J, Belman, ND, Geller, R, Nieva, J, Whittenberger, BP, Wong, BMY, Cescon, TP, Abesada-Terk, G, Jr, Guarino, MJ, Zweibach, A, Ibrahim, EN, Takahashi, G, Garrison, MA, Mowat, RB, Choi, BS, Oliff, IA, Singh, J, Guter, KA, Ayrons, K, Rowland, KM, Noga, SJ, Rao, SB, Columbie, A, Nualart, MT, Cecchi, GR, Campos, LT, Mohebtash, M, Flores, MR, Rothstein-Rubin, R, O'Connor, BM, Soori, G, Knapp, M, Miranda, FG, Goodgame, BW, Kassem, M, Belani, R, Sharma, S, Ortiz, T, Sonneborn, HL, Markowitz, AB, Wilbur, D, Meiri, E, Koo, VS, Jhangiani, HS, Wong, L, Sanani, S, Lawrence, SJ, Jones, CM, Murray, C, Papageorgiou, C, Gurtler, JS, Ascensao, JL, Venigalla, ML, D'Andrea, M, De Las Casas, C, Haile, DJ, Qazi, FU, Santander, JL, Thomas, MR, Rao, VP, Craig, M, Garg, RJ, Robles, R, Lyons, RM, Stegemoller, RK, Goel, S, Garg, S, Lowry, P, Lynch, C, Lash, B, Repka, T, Baker, J, Goueli, BS, Campbell, TC, Van Echo, DA, Lee, YJ, Reyes, EA, Senecal, FM, Donnelly, G, Byeff, P, Weiss, R, Reid, T, Roeland, E, Goel, A, Prow, DM, Brandt, DS, Kaplan, HG, Payne, JE, Boeckh, MG, Rosen, PJ, Mena, RR, Khan, R, Betts, RF, Sharp, SA, Morrison, VA, Fitz-Patrick, D, Congdon, J, Erickson, N, Abbasi, R, Henderson, S, Mehdi, A, Wos, EJ, Rehmus, E, Beltzer, L, Tamayo, RA, Mahmood, T, Reboli, AC, Moore, A, Brown, JM, Cruz, J, Quick, DP, Potz, JL, Kotz, KW, Hutchins, M, Chowhan, NM, Devabhaktuni, YD, Braly, P, Berenguer, RA, Shambaugh, SC, O'Rourke, TJ, Conkright, WA, Winkler, CF, Addo, FEK, Duic, JP, High, KP, Kutner, ME, Collins, R, Carrizosa, DR, Perry, DJ, Kailath, E, Rosen, N, Sotolongo, R, Shoham, S, Chen, T, Mullane, Kathleen M, Morrison, Vicki A, Camacho, Luis H, Arvin, Ann, McNeil, Shelly A, Durrand, Jessie, Campbell, Bernadette, Su, Shu-Chih, Chan, Ivan S F, Parrino, Janie, Kaplan, Susan S, Popmihajlov, Zoran, and Annunziato, Paula W

Published
2019
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15. The GERDA experiment for the search of 0\nu\beta\beta\ decay in ^{76}Ge

Author

GERDA Collaboration, Ackermann, K. -H., Agostini, M., Allardt, M., Altmann, M., Andreotti, E., Bakalyarov, A. M., Balata, M., Barabanov, I., Heider, M. Barnabe, Barros, N., Baudis, L., Bauer, C., Becerici-Schmidt, N., Bellotti, E., Belogurov, S., Belyaev, S. T., Benato, G., Bettini, A., Bezrukov, L., Bode, T., Brudanin, V., Brugnera, R., Budjas, D., Caldwell, A., Cattadori, C., Chernogorov, A., Chkvorets, O., Cossavella, F., D`Andragora, A., Demidova, E. V., Denisov, A., di Vacri, A., Domula, A., Egorov, V., Falkenstein, R., Ferella, A., Freund, K., Froborg, F., Frodyma, N., Gangapshev, A., Garfagnini, A., Gasparro, J., Gazzana, S., de Orduna, R. Gonzalez, Grabmayr, P., Gurentsov, V., Gusev, K., Guthikonda, K. K., Hampel, W., Hegai, A., Heisel, M., Hemmer, S., Heusser, G., Hofmann, W., Hult, M., Inzhechik, L. V., Ioannucci, L., Csalty, J. Janicsko, Jochum, J., Junker, M., Kankanyan, R., Kianovsky, S., Kihm, T., Kiko, J., Kirpichnikov, I. V., Kirsch, A., Klimenko, A., Knapp, M., Knöpfle, K. T., Kochetov, O., Kornoukhov, V. N., Kröninger, K., Kusminov, V., Laubenstein, M., Lazzaro, A., Lebedev, V. I., Lehnert, B., Lenz, D., Liao, H., Lindner, M., Lippi, I., Liu, J., Liu, X., Lubashevskiy, A., Lubsandorzhiev, B., Machado, A. A., Majorovits, B., Maneschg, W., Marissens, G., Mayer, S., Meierhofer, G., Nemchenok, I., Niedermeier, L., Nisi, S., Oehm, J., O'Shaughnessy, C., Pandola, L., Peiffer, P., Pelczar, K., Pullia, A., Riboldi, S., Ritter, F., Alvarez, C. Rossi, Sada, C., Salathe, M., Schmitt, C., Schönert, S., Schreiner, J., Schubert, J., Schulz, O., Schwan, U., Schwingenheuer, B., Seitz, H., Shevchik, E., Shirchenko, M., Simgen, H., Smolnikov, A., Stanco, L., Stelzer, F., Strecker, H., Tarka, M., Trunk, U., Ur, C. A., Vasenko, A. A., Vogt, S., Volynets, O., von Sturm, K., Wagner, V., Walter, M., Wegmann, A., Wojcik, M., Yanovich, E., Zavarise, P., Zhitnikov, I., Zhukov, S. V., Zinatulina, D., Zuber, K., and Zuzel, G.

Subjects
Physics - Instrumentation and Detectors, High Energy Physics - Experiment, Nuclear Experiment
Abstract

The GERDA collaboration is performing a search for neutrinoless double beta decay of ^{76}Ge with the eponymous detector. The experiment has been installed and commissioned at the Laboratori Nazionali del Gran Sasso and has started operation in November 2011. The design, construction and first operational results are described, along with detailed information from the R&D phase., Comment: 31 pages, 23 figures, submitted to EPJC

Published
2012
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17. Use and costs of services and unpaid care for people with mild-to-moderate dementia: Baseline results from the IDEAL cohort study

Author

Clare, L., Jones, I.R., Victor, C.R., Hindle, J.V., Jones, R.W., Knapp, M., Kopelman, M.D., Litherland, R., Martyr, A., Matthews, F.E., Morris, R.G., Nelis, S.M., Pickett, J.A., Quinn, C., Rusted, J.M., Thom, J.M., Henderson, Catherine, Knapp, Martin, Nelis, Sharon M., Quinn, Catherine, Martyr, Anthony, Wu, Yu-Tzu, Jones, Ian R., Victor, Christina R., Pickett, James A., Hindle, John V., Jones, Roy W., Kopelman, Michael D., Matthews, Fiona E., Morris, Robin G., Rusted, Jennifer M., Thom, Jeanette M., and Clare, Linda

Published
2019
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19. The nature of iron-oxygen vacancy defect centers in PbTiO3

Author

Mestric, H., Eichel, R. -A., Kloss, T., Dinse, K. -P., Laubach, So., Laubach, St., Schmidt, P. C., Schoenau, K. A., Knapp, M., and Ehrenberg, H.

Subjects
Condensed Matter - Materials Science
Abstract

The iron(III) center in ferroelectric PbTiO3 together with an oxygen vacancy forms a charged defect associate, oriented along the crystallographic c-axis. Its microscopic structure has been analyzed in detail comparing results from a semi-empirical Newman superposition model analysis based on finestructure data and from calculations using density functional theory. Both methods give evidence for a substitution of Fe3+ for Ti4+ as an acceptor center. The position of the iron ion in the ferroelectric phase is found to be similar to the B-site in the paraelectric phase. Partial charge compensation is locally provided by a directly coordinated oxygen vacancy. Using high-resolution synchrotron powder diffraction, it was verified that lead titanate remains tetragonal down to 12 K, exhibiting a c/a-ratio of 1.0721., Comment: 11 pages, 5 figures, accepted in Phys. Rev. B

Published
2005
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21. The Gerda experiment for the search of 0νββ decay in 76Ge

Author

Ackermann, K-H, Agostini, M, Allardt, M, Altmann, M, Andreotti, E, Bakalyarov, AM, Balata, M, Barabanov, I, Barnabé Heider, M, Barros, N, Baudis, L, Bauer, C, Becerici-Schmidt, N, Bellotti, E, Belogurov, S, Belyaev, ST, Benato, G, Bettini, A, Bezrukov, L, Bode, T, Brudanin, V, Brugnera, R, Budjáš, D, Caldwell, A, Cattadori, C, Chernogorov, A, Chkvorets, O, Cossavella, F, D‘Andragora, A, Demidova, EV, Denisov, A, di Vacri, A, Domula, A, Egorov, V, Falkenstein, R, Ferella, A, Freund, K, Froborg, F, Frodyma, N, Gangapshev, A, Garfagnini, A, Gasparro, J, Gazzana, S, Gonzalez de Orduna, R, Grabmayr, P, Gurentsov, V, Gusev, K, Guthikonda, KK, Hampel, W, Hegai, A, Heisel, M, Hemmer, S, Heusser, G, Hofmann, W, Hult, M, Inzhechik, LV, Ioannucci, L, Janicskó Csáthy, J, Jochum, J, Junker, M, Kankanyan, R, Kianovsky, S, Kihm, T, Kiko, J, Kirpichnikov, IV, Kirsch, A, Klimenko, A, Knapp, M, Knöpfle, KT, Kochetov, O, Kornoukhov, VN, Kröninger, K, Kusminov, V, Laubenstein, M, Lazzaro, A, Lebedev, VI, Lehnert, B, Lenz, D, Liao, H, Lindner, M, Lippi, I, Liu, J, Liu, X, Lubashevskiy, A, Lubsandorzhiev, B, Machado, AA, Majorovits, B, Maneschg, W, Marissens, G, Mayer, S, Meierhofer, G, Nemchenok, I, Niedermeier, L, Nisi, S, Oehm, J, O’Shaughnessy, C, Pandola, L, Peiffer, P, Pelczar, K, and Pullia, A

Subjects
Nuclear and Plasma Physics, Particle and High Energy Physics, Physical Sciences, physics.ins-det, hep-ex, nucl-ex, Atomic, Molecular, Nuclear, Particle and Plasma Physics, Quantum Physics, Nuclear & Particles Physics, Astronomical sciences, Atomic, molecular and optical physics, Particle and high energy physics
Abstract

The Gerda collaboration is performing a search for neutrinoless double beta decay of 76Ge with the eponymous detector. The experiment has been installed and commissioned at the Laboratori Nazionali del Gran Sasso and has started operation in November 2011. The design, construction and first operational results are described, along with detailed information from the R&D phase. © 2013 The Author(s).

Published
2013

25. Sources and directions of social support and life satisfaction among solitary Chinese older adults in Hong Kong: the mediating role of sense of loneliness

Author

Bai X, Yang SY, and Knapp M

Subjects
life satisfaction, path analysis, solitary older adults, loneliness, social support, Geriatrics, RC952-954.6
Abstract

Xue Bai,1 Shuyan Yang,2 Martin Knapp3 1Department of Applied Social Sciences, The Hong Kong Polytechnic University, Hong Kong, People’s Republic of China; 2Department of Social Work, Hong Kong Baptist University, Hong Kong, People’s Republic of China; 3Personal Social Services Research Unit, London School of Economics and Political Science, London, UK Abstract: Based on survey data collected from 151 community-dwelling solitary Chinese older adults in Hong Kong, the present study used path analysis to examine the mediating role of sense of loneliness in the relationship between different sources and directions of social support and life satisfaction. The results showed that sense of loneliness mediated the effects of support from families, friends, and support for others on life satisfaction. In addition, a formal source of social support was not associated with life satisfaction among solitary older adults, although those with a more secure financial status had greater overall life satisfaction. These findings highlight the importance of enhancing awareness among social and health care service providers about the negative effects of insufficient social support on older adults’ sense of loneliness and life satisfaction. Family and friendship networks should be expanded for solitary older adults. Keywords: life satisfaction, path analysis, solitary older adults, sense of loneliness, social support

Published
2018

26. Factors associated with failure to achieve remission and with relapse after remission in patients with major depressive disorder in the PERFORM study

Author

Saragoussi D, Touya M, Haro JM, Jönsson B, Knapp M, Botrel B, Florea I, Loft H, and Rive B

Subjects
major depressive disorder, remission, relapse, patient-reported cognitive dysfunction, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Delphine Saragoussi,1 Maëlys Touya,2 Josep Maria Haro,3 Bengt Jönsson,4 Martin Knapp,5 Bastien Botrel,6 Ioana Florea,7 Henrik Loft,8 Benoît Rive9 1Real-World Evidence and Epidemiology, Lundbeck SAS, Issy-les-Moulineaux, France; 2Health Economics and Outcomes Research, Lundbeck, Deerfield, IL, US; 3Research and Teaching Unit, Parc Sanitari Sant Joan de Deu, CIBERSAM, University of Barcelona, Sant Boi de Llobregat, Barcelona, Spain; 4Department of Economics, Stockholm School of Economics, Stockholm, Sweden; 5Department of Health Policy, London School of Economics and Political Science, London, UK; 6Biostatistics, Inferential, Paris, France; 7Clinical Research Paediatrics, H. Lundbeck A/S, Valby, Denmark; 8Biometrics, H. Lundbeck A/S, Valby, Denmark; 9Global Analytics, Lundbeck SAS, Issy-les-Moulineaux, France Background: The Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder (PERFORM) study has been initiated to better understand the course of a depressive episode and its impact on patient functioning. This analysis aimed to identify sociodemographic and clinical factors associated with failure to achieve remission at month 2 after initiating or switching antidepressant monotherapy and with subsequent relapse at month 6 for patients in remission at month 2. Materials and methods: This was a 2-year observational cohort study in 1,159 outpatients aged 18–65 years with major depressive disorder initiating or undergoing the first switch of antidepressant monotherapy. Factors with P8 weeks (OR 0.51), being in psychotherapy (OR 0.51), sexual dysfunction (OR 0.62), and severity of depression (OR 0.87). Factors significantly associated with relapse at month 6 were male sex (OR 2.47), being married or living as a couple (OR 2.73), residual patient-reported cognitive symptoms at 2 months (OR 1.12 per additional unit of Perceived Deficit Questionnaire-5 score) and residual depressive symptoms at 2 months (OR 1.27 per additional unit of Patient Health Questionnaire-9 score). Conclusion: Different factors appear to be associated with failure to achieve remission in patients with major depressive disorder and with subsequent relapse in patients who do achieve remission. Patient-reported cognitive dysfunction is an easily measurable and treatable characteristic that may be associated with an increased likelihood of relapse at 6 months in patients who have achieved remission. Keywords: major depressive disorder, remission, relapse, patient-reported cognitive dysfunction

Published
2017

27. Identification of de novo variants in nonsyndromic cleft lip with/without cleft palate patients with low polygenic risk scores.

Author

Ishorst, N., Henschel, L., Thieme, F., Drichel, D., Sivalingam, S., Mehrem, S.L., Fechtner, A.C., Fazaal, J., Welzenbach, J., Heimbach, A., Maj, C., Borisov, O., Hausen, J., Raff, R., Hoischen, A., Dixon, M., Rada-Iglesias, A., Bartusel, M., Rojas-Martinez, A., Aldhorae, K., Braumann, B., Kruse, T., Kirschneck, C., Spanier, G., Reutter, H., Nowak, S., Gölz, L., Knapp, M., Buness, A., Krawitz, P., Nöthen, M.M., Nothnagel, M., Becker, T., Ludwig, K.U., Mangold, E., Ishorst, N., Henschel, L., Thieme, F., Drichel, D., Sivalingam, S., Mehrem, S.L., Fechtner, A.C., Fazaal, J., Welzenbach, J., Heimbach, A., Maj, C., Borisov, O., Hausen, J., Raff, R., Hoischen, A., Dixon, M., Rada-Iglesias, A., Bartusel, M., Rojas-Martinez, A., Aldhorae, K., Braumann, B., Kruse, T., Kirschneck, C., Spanier, G., Reutter, H., Nowak, S., Gölz, L., Knapp, M., Buness, A., Krawitz, P., Nöthen, M.M., Nothnagel, M., Becker, T., Ludwig, K.U., and Mangold, E.

Abstract

Item does not contain fulltext, BACKGROUND: Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome-wide significant risk loci, which explain less than 40% of nsCL/P heritability. Studies show that some of the hidden heritability is explained by rare penetrant variants. METHODS: To identify new candidate genes, we searched for highly penetrant de novo variants (DNVs) in 50 nsCL/P patient/parent-trios with a low polygenic risk for the phenotype (discovery). We prioritized DNV-carrying candidate genes from the discovery for resequencing in independent cohorts of 1010 nsCL/P patients of diverse ethnicities and 1574 population-matched controls (replication). Segregation analyses and rare variant association in the replication cohort, in combination with additional data (genome-wide association data, expression, protein-protein-interactions), were used for final prioritization. CONCLUSION: In the discovery step, 60 DNVs were identified in 60 genes, including a variant in the established nsCL/P risk gene CDH1. Re-sequencing of 32 prioritized genes led to the identification of 373 rare, likely pathogenic variants. Finally, MDN1 and PAXIP1 were prioritized as top candidates. Our findings demonstrate that DNV detection, including polygenic risk score analysis, is a powerful tool for identifying nsCL/P candidate genes, which can also be applied to other multifactorial congenital malformations.

Published
2023

28. Mental health service areas in Switzerland.

Author

Stulz, N, Jörg, R, Reim-Gautier, C, Bonsack, C, Conus, P, Evans-Lacko, S, Gabriel-Felleiter, K, Heim, E, Jäger, M, Knapp, M, Richter, D, Schneeberger, A, Thornicroft, G, Traber, R, Wieser, S, Tuch, A, Hepp, U, Stulz, N, Jörg, R, Reim-Gautier, C, Bonsack, C, Conus, P, Evans-Lacko, S, Gabriel-Felleiter, K, Heim, E, Jäger, M, Knapp, M, Richter, D, Schneeberger, A, Thornicroft, G, Traber, R, Wieser, S, Tuch, A, and Hepp, U

Abstract

OBJECTIVES: Small area analysis is a health services research technique that facilitates geographical comparison of services supply and utilization rates between health service areas (HSAs). HSAs are functionally relevant regions around medical facilities within which most residents undergo treatment. We aimed to identify HSAs for psychiatric outpatient care (HSA-PSY) in Switzerland. METHODS: We used HSAr, a new and automated methodological approach, and comprehensive psychiatric service use data from insurances to identify HSA-PSY based on travel patterns between patients' residences and service sites. Resulting HSA-PSY were compared geographically, demographically and regarding the use of inpatient and outpatient psychiatric services. RESULTS: We identified 68 HSA-PSY, which were reviewed and validated by local mental health services experts. The population-based rate of inpatient and outpatient service utilization varied considerably between HSA-PSY. Utilization of inpatient and outpatient services tended to be positively associated across HSA-PSY. CONCLUSIONS: Wide variation of service use between HSA-PSY can hardly be fully explained by underlying differences in the prevalence or incidence of disorders. Whether other factors such as the amount of services supply did add to the high variation should be addressed in further studies, for which our functional mapping on a small-scale regional level provides a good analytical framework.

Published
2023

29. Dementia prevention:the potential long-term cost-effectiveness of the FINGER prevention program

Author

Wimo, A. (Anders), Handels, R. (Ron), Antikainen, R. (Riitta), Eriksdotter, M. (Maria), Jönsson, L. (Linus), Knapp, M. (Martin), Kulmala, J. (Jenni), Laatikainen, T. (Tiina), Lehtisalo, J. (Jenni), Peltonen, M. (Markku), Sköldunger, A. (Anders), Soininen, H. (Hilkka), Solomon, A. (Alina), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Ngandu, T. (Tiia), Kivipelto, M. (Miia), Wimo, A. (Anders), Handels, R. (Ron), Antikainen, R. (Riitta), Eriksdotter, M. (Maria), Jönsson, L. (Linus), Knapp, M. (Martin), Kulmala, J. (Jenni), Laatikainen, T. (Tiina), Lehtisalo, J. (Jenni), Peltonen, M. (Markku), Sköldunger, A. (Anders), Soininen, H. (Hilkka), Solomon, A. (Alina), Strandberg, T. (Timo), Tuomilehto, J. (Jaakko), Ngandu, T. (Tiia), and Kivipelto, M. (Miia)

Abstract

Introduction: The aim of this study was to estimate the potential cost-effectiveness of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) program. Methods: A life-time Markov model with societal perspective, simulating a cohort of people at risk of dementia reflecting usual care and the FINGER program. Results: Costs were 1,653,275 and 1,635,346 SEK and quality-adjusted life years (QALYs) were 8.636 and 8.679 for usual care and the FINGER program, respectively, resulting in savings of 16,928 SEK (2023 US$) and 0.043 QALY gains per person, supporting extended dominance for the FINGER program. A total of 1623 dementia cases were avoided with 0.17 fewer person-years living with dementia. The sensitivity analysis confirmed the conclusions in most scenarios. Discussion: The model provides support that programs like FINGER have the potential to be cost-effective in preventing dementia. Results at the individual level are rather modest, but the societal benefits can be substantial because of the large potential target population.

Published
2023

30. Embracing paradox and contingency: integration mechanisms for ambidextrous innovation portfolio management

Author

Killen, CP, Sankaran, S, Knapp, M, Stevens, C, Killen, CP, Sankaran, S, Knapp, M, and Stevens, C

Abstract

Purpose: The purpose of this paper is to explore how organizations manage and integrate exploration and exploitation across the innovation project portfolio. Such ambidextrous capabilities are required for organizations to innovate and succeed in today's rapidly changing competitive environment. Understanding how exploration and exploitation projects are integrated can illustrate ways to enhance ambidexterity and boost learning for the benefit of both approaches. Design/methodology/approach: A multiple-case study approach was used to explore innovation portfolio management in six large organizations that emphasize innovation in their strategies. Findings: The findings draw upon concepts of paradox and contingency to reveal that the inherent tension between formality and flexibility in managing innovation project portfolios is aligned with the need for organizational ambidexterity that maintains effective exploitative innovation while supporting explorative innovation capabilities. Four integration mechanisms are identified that enhance ambidexterity across the innovation portfolio by embedding processes for transition from exploration to exploitation and cross-fertilizing knowledge to build innovation capability across both exploration and exploitation. Practical implications: Managers may find inspiration on ways to enhance learning by bridging exploration and exploitation projects from the four types of integration mechanisms. Recognizing the paradoxical nature of the tension between formality and flexibility in project and portfolio management may also help guide organizations to effectively develop ambidextrous approaches to enhance overall innovation outcomes. Originality/value: In contrast to perspectives which suggest that paradox and contingency approaches represent disparate perspectives, the authors demonstrate how they can complement each other and work together through innovation portfolio management to support ambidexterity at the portfolio and project

Published
2023

31. Dissecting the genetic heterogeneity of gastric cancer

Author

Hess, T., Maj, C., Gehlen, J., Borisov, O., Haas, S. L., Gockel, I., Vieth, M., Piessen, G., Alakus, H., Vashist, Y., Pereira, C., Knapp, M., Schuller, V., Quaas, A., Grabsch, H. I., Trautmann, J., Malecka-Wojciesko, E., Mokrowiecka, A., Speller, J., Mayr, A., Schroder, J., Hillmer, A. M., Heider, D., Lordick, F., Perez-Aisa, A., Campo, R., Espinel, J., Geijo, F., Thomson, C., Bujanda, L., Sopena, F., Lanas, A., Pellise, M., Pauligk, C., Goetze, T. O., Zelck, C., Reingruber, J., Hassanin, E., Elbe, P., Alsabeah, S., Lindblad, M., Nilsson, M., Kreuser, N., Thieme, R., Tavano, F., Pastorino, Roberta, Arzani, D., Persiani, Roberto, Jung, J. -O., Nienhuser, H., Ott, K., Schumann, R. R., Kumpf, O., Burock, S., Arndt, V., Jakubowska, A., Lawniczak, M., Moreno, V., Martin, V., Kogevinas, M., Pollan, M., Dabrowska, J., Salas, A., Cussenot, O., Boland-Auge, A., Daian, D., Deleuze, J. -F., Salvi, E., Teder-Laving, M., Tomasello, G., Ratti, M., Senti, C., De Re, V., Steffan, A., Holscher, A. H., Messerle, K., Bruns, C. J., Sivins, A., Bogdanova, I., Skieceviciene, J., Arstikyte, J., Moehler, M., Lang, H., Grimminger, P. P., Kruschewski, M., Vassos, N., Schildberg, C., Lingohr, P., Ridwelski, K., Lippert, H., Fricker, N., Krawitz, P., Hoffmann, Christian Pieter, Nothen, M. M., Veits, L., Izbicki, J. R., Mostowska, A., Martinon-Torres, F., Cusi, D., Adolfsson, R., Cancel-Tassin, G., Hoblinger, A., Rodermann, E., Ludwig, M., Keller, G., Metspalu, A., Brenner, H., Heller, J., Neef, M., Schepke, M., Dumoulin, F. L., Hamann, L., Cannizzaro, Rino, Ghidini, Maria Candida, Plassmann, D., Geppert, M., Malfertheiner, P., Gehlen, O., Skoczylas, T., Majewski, M., Lubinski, J., Palmieri, O., Boccia, Stefania, Latiano, A., Aragones, N., Schmidt, T., Dinis-Ribeiro, M., Medeiros, R., Al-Batran, S. -E., Leja, M., Kupcinskas, J., Garcia-Gonzalez, M. A., Venerito, M., Schumacher, J., Pastorino R. (ORCID:0000-0001-5013-0733), Persiani R. (ORCID:0000-0002-1537-5097), Hoffmann P., Cannizzaro R., Ghidini M., Boccia S. (ORCID:0000-0002-1864-749X), Hess, T., Maj, C., Gehlen, J., Borisov, O., Haas, S. L., Gockel, I., Vieth, M., Piessen, G., Alakus, H., Vashist, Y., Pereira, C., Knapp, M., Schuller, V., Quaas, A., Grabsch, H. I., Trautmann, J., Malecka-Wojciesko, E., Mokrowiecka, A., Speller, J., Mayr, A., Schroder, J., Hillmer, A. M., Heider, D., Lordick, F., Perez-Aisa, A., Campo, R., Espinel, J., Geijo, F., Thomson, C., Bujanda, L., Sopena, F., Lanas, A., Pellise, M., Pauligk, C., Goetze, T. O., Zelck, C., Reingruber, J., Hassanin, E., Elbe, P., Alsabeah, S., Lindblad, M., Nilsson, M., Kreuser, N., Thieme, R., Tavano, F., Pastorino, Roberta, Arzani, D., Persiani, Roberto, Jung, J. -O., Nienhuser, H., Ott, K., Schumann, R. R., Kumpf, O., Burock, S., Arndt, V., Jakubowska, A., Lawniczak, M., Moreno, V., Martin, V., Kogevinas, M., Pollan, M., Dabrowska, J., Salas, A., Cussenot, O., Boland-Auge, A., Daian, D., Deleuze, J. -F., Salvi, E., Teder-Laving, M., Tomasello, G., Ratti, M., Senti, C., De Re, V., Steffan, A., Holscher, A. H., Messerle, K., Bruns, C. J., Sivins, A., Bogdanova, I., Skieceviciene, J., Arstikyte, J., Moehler, M., Lang, H., Grimminger, P. P., Kruschewski, M., Vassos, N., Schildberg, C., Lingohr, P., Ridwelski, K., Lippert, H., Fricker, N., Krawitz, P., Hoffmann, Christian Pieter, Nothen, M. M., Veits, L., Izbicki, J. R., Mostowska, A., Martinon-Torres, F., Cusi, D., Adolfsson, R., Cancel-Tassin, G., Hoblinger, A., Rodermann, E., Ludwig, M., Keller, G., Metspalu, A., Brenner, H., Heller, J., Neef, M., Schepke, M., Dumoulin, F. L., Hamann, L., Cannizzaro, Rino, Ghidini, Maria Candida, Plassmann, D., Geppert, M., Malfertheiner, P., Gehlen, O., Skoczylas, T., Majewski, M., Lubinski, J., Palmieri, O., Boccia, Stefania, Latiano, A., Aragones, N., Schmidt, T., Dinis-Ribeiro, M., Medeiros, R., Al-Batran, S. -E., Leja, M., Kupcinskas, J., Garcia-Gonzalez, M. A., Venerito, M., Schumacher, J., Pastorino R. (ORCID:0000-0001-5013-0733), Persiani R. (ORCID:0000-0002-1537-5097), Hoffmann P., Cannizzaro R., Ghidini M., and Boccia S. (ORCID:0000-0002-1864-749X)

Abstract

Background: Gastric cancer (GC) is clinically heterogenous according to location (cardia/non-cardia) and histopathology (diffuse/intestinal). We aimed to characterize the genetic risk architecture of GC according to its subtypes. Another aim was to examine whether cardia GC and oesophageal adenocarcinoma (OAC) and its precursor lesion Barrett's oesophagus (BO), which are all located at the gastro-oesophageal junction (GOJ), share polygenic risk architecture. Methods: We did a meta-analysis of ten European genome-wide association studies (GWAS) of GC and its subtypes. All patients had a histopathologically confirmed diagnosis of gastric adenocarcinoma. For the identification of risk genes among GWAS loci we did a transcriptome-wide association study (TWAS) and expression quantitative trait locus (eQTL) study from gastric corpus and antrum mucosa. To test whether cardia GC and OAC/BO share genetic aetiology we also used a European GWAS sample with OAC/BO. Findings: Our GWAS consisting of 5816 patients and 10,999 controls highlights the genetic heterogeneity of GC according to its subtypes. We newly identified two and replicated five GC risk loci, all of them with subtype-specific association. The gastric transcriptome data consisting of 361 corpus and 342 antrum mucosa samples revealed that an upregulated expression of MUC1, ANKRD50, PTGER4, and PSCA are plausible GC-pathomechanisms at four GWAS loci. At another risk locus, we found that the blood-group 0 exerts protective effects for non-cardia and diffuse GC, while blood-group A increases risk for both GC subtypes. Furthermore, our GWAS on cardia GC and OAC/BO (10,279 patients, 16,527 controls) showed that both cancer entities share genetic aetiology at the polygenic level and identified two new risk loci on the single-marker level. Interpretation: Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular me

Published
2023

35. The state of the art in European research on reducing social exclusion and stigma related to mental health: A systematic mapping of the literature

Author

McDaid, D., Thornicroft, G., Evans-Lacko, S., Courtin, E., Fiorillo, A., Knapp, M., Luciano, M., Park, A.-L., Brunn, M., Byford, S., Chevreul, K., Forsman, A.K., Gulacsi, L., Haro, J.M., Kennelly, B., Knappe, S., Lai, T., Lasalvia, A., Miret, M., O'Sullivan, C., Obradors-Tarragó, C., Rüsch, N., Sartorius, N., Švab, V., van Weeghel, J., Van Audenhove, C., Wahlbeck, K., and Zlati, A.

Published
2014
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38. Magnetic Fields of Extrasolar Planets: Planetary Interiors and Habitability

Author

Brain, D.A, Turner, J.D, Lynch, C.R, Knapp, M, Zarka, P, Wolszczan, Alex, Rogers, L.A, Murphy, T, Kasper, J.C, Farrell, W.M, Griessmeier, J.M, Driscoll, P.E, Dong, C.F, Airapetian, V, Hallinan, G, and Lazio, J

Abstract

Jupiter’s radio emission has been linked to its planetary-scale magnetic field, and spacecraft investigations have revealed that most planets, and some moons, have or had a global magnetic field. Generated by internal dynamos, magnetic fields are one of the few remote sensing means of constraining the properties of planetary interiors. For the Earth, its magnetic field has been speculated to be partially responsible for its habitability, and knowledge of an extrasolar planet’s magnetic field may be necessary to assess its habitability. The radio emission from Jupiter and other solar system planets is produced by an electron cyclotron maser, and detections of extrasolar planetary electron cyclotron masers will enable measurements of extrasolar planetary magnetic fields.

Published
2018

45. The Treatment of Challenging Behaviour in Intellectual Disabilities: Cost-Effectiveness Analysis

Author

Romeo, R., Knapp, M., Tyrer, P., Crawford, M., and Oliver-Africano, P.

Abstract

Background: Antipsychotic drugs are used in the routine treatment of adults with intellectual disabilities (ID) and challenging behaviour in the UK despite limited evidence of their effectiveness. There is no evidence on their cost-effectiveness. Methods: The relative cost-effectiveness of risperidone, haloperidol and placebo in treating individuals with an ID and challenging behaviour was compared from a societal perspective in a 26-week, double-blind, randomised controlled trial. Outcomes were changes in aggression and quality of life. Costs measured all service impacts and unpaid caregiver inputs. Results: After 26 weeks, patients randomised to placebo had lower costs compared with those in the risperidone and haloperidol treatment groups. Aggression was highest for patients treated with risperidone and lowest for patients treated with haloperidol; however, quality of life was lowest for patients treated with haloperidol and highest for patients treated with risperidone. Conclusion: The treatment of challenging behaviour in ID with antipsychotic drugs is not a cost-effective option.

Published
2009
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46. Cost Estimation of a Health-Check Intervention for Adults with Intellectual Disabilities in the UK

Author

Romeo, R., Knapp, M., Morrison, J., Melville, C., Allan, L., Finlayson, J., and Cooper, S.-A

Abstract

Background: High rates of health needs among adults with intellectual disabilities flag the need for information about the economic consequences of strategies to identify and address unmet needs. Health-check interventions are one such strategy, and have been demonstrated to effect health gains over the following 12-month period. However, little is known about their effects on service use and costs, and hence how affordable such interventions are. Methods: We examined service use patterns and costs over a 12-month period for 50 adult participants with intellectual disabilities who received a health-check intervention and 50 individually matched control participants who received standard care only. Results: The health-check intervention was cheap, and it did "not" have associated higher costs in terms of service usage. Indeed, mean cost of care for the adults who received standard care only was greater than for the adults who received the health-check intervention. The higher costs were due to differences in unpaid carer support costs. Conclusion: This is the first study to report the associated service use, and costs of a health-check intervention to improve the health of adults with intellectual disabilities and reduce health inequalities. Results suggest this intervention is cheap and affordable compared with standard care, supporting clinical outcome evidence for its introduction into health care policy and implementation. However, further research is needed to confirm this finding with a larger sample.

Published
2009
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47. Person-Centred Planning: Factors Associated with Successful Outcomes for People with Intellectual Disabilities

Author

Robertson, J., Emerson, E., Hatton, C., Elliott, J., McIntosh, B., Swift, P., Krinjen-Kemp, E., Towers, C., Romeo, R., Knapp, M., Sanderson, H., Routledge, M., Oakes, P., and Joyce, T.

Abstract

Background: Recent research in the USA and UK indicates that person-centred planning (PCP) can lead to improvements in lifestyle-related outcomes for people with intellectual disabilities (ID). It is clear, however, that the introduction of PCP does not have an equal impact for all participants. The aim of the present paper was to identify factors associated with the probability of delivering a plan and with improvements in outcomes for those who did receive a plan. Methods: Information on the life experiences of participants was collected over a period of approximately 2 years for a cohort of 93 adults with ID. Results: There were powerful inequalities in both access to and the efficacy of PCP in relation to participant characteristics, contextual factors and elements of the PCP process. Conclusions: Results are discussed in relation to implications for policy and practice for increasing the effectiveness of PCP and reducing inequalities in the life experiences of people with ID.

Published
2007
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49. The cost of schizophrenia in Japan

Author

Sado M, Inagaki A, Koreki A, Knapp M, Kissane LA, Mimura M, and Yoshimura K

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Mitsuhiro Sado,1 Ataru Inagaki,2 Akihiro Koreki,1 Martin Knapp,3 Lee Andrew Kissane,4 Masaru Mimura,1 Kimio Yoshimura4 1Department of Neuropsychiatry, Keio University School of Medicine, 2Center for Clinical Psychopharmacology, Institute of Neuropsychiatry, Tokyo, Japan; 3Department of Social Policy, London School of Economics and Political Science, London, UK; 4Department of Health Policy and Management, Keio University School of Medicine, Tokyo, Japan Introduction: Schizophrenia is a disorder that produces considerable burdens due to its often relapsing/remitting or chronic longitudinal course. This burden is felt not only by patients themselves, but also by their families and health care systems. Although the societal burden caused by this disorder has been evaluated in several countries, the magnitude of the societal cost of schizophrenia in Japan has never been estimated. The aim of this study is to clarify the societal burden of schizophrenia by estimating the cost of schizophrenia in Japan in 2008. Methods: A human capital approach was adopted to estimate the cost of schizophrenia. The total cost of schizophrenia was calculated as the sum of the direct, morbidity, and mortality costs. Schizophrenia was defined as disorders coded as F20.0–F20.9 according to the International Classification of Diseases-10. The data required to estimate the total cost was collected from publicly available statistics or previously reported studies. Results: The total cost of schizophrenia in Japan in 2008 was JPY 2.77 trillion (USD 23.8 billion). While the direct cost was JPY 0.770 trillion (USD 6.59 billion), the morbidity and mortality costs were JPY 1.85 trillion (USD 15.8 billion) and JPY 0.155 trillion (USD 1.33 billion), respectively. Conclusion: The societal burden caused by schizophrenia is tremendous in Japan, similar to that in other developed countries where published data exist. Compared with other disorders, such as depression or anxiety disorders, the direct cost accounted for a relatively high proportion of the total cost. Furthermore, absolute costs arising from unemployment were larger, while the prevalence rate was smaller, than the corresponding results for depression or anxiety in Japan. Keywords: cost of illness, schizophrenia, societal burden, cost analysis, societal cost

Published
2013

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