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Your search keyword '"Knudsen, L. K."' showing total 5 results
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5 results on '"Knudsen, L. K."'

2. Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011

Author

Larsen, J., Petersen, A., Sørum, M., Stegger, M., van Alphen, L., Valentiner-Branth, P., Knudsen, L. K., Larsen, Lars Stehr, Feingold, B., Price, L. B., Andersen, P. S., Larsen, A. R., Skov, R. L., Larsen, J., Petersen, A., Sørum, M., Stegger, M., van Alphen, L., Valentiner-Branth, P., Knudsen, L. K., Larsen, Lars Stehr, Feingold, B., Price, L. B., Andersen, P. S., Larsen, A. R., and Skov, R. L.

Abstract

Livestock constitutes a potential reservoir of meticillin-resistant Staphylococcus aureus isolates belonging to a recently derived lineage within clonal complex 398 (MRSA CC398-IIa). Since its discovery in the early 2000s, this lineage has become a major cause of human disease in Europe, posing a serious public health challenge in countries with intensive livestock production. To retrace the history of human colonisation and infection with MRSA CC398-IIa in Denmark, we conducted a nationwide, retrospective study of MRSA isolates collected from 1999 to 2011. Among 7,429 MRSA isolates screened, we identified 416 MRSA CC398-IIa isolates. Of these, 148 were from people with infections, including 51 from patients reporting no livestock exposure. The first cases of MRSA CC398-IIa infection in Denmark occurred in 2004. Subsequently, the incidence of MRSA CC398-IIa infection showed a linear annual increase of 66% from 2004 to 2011 (from 0.09 to 1.1 per 100,000 person-years). There were clear temporal and spatial relationships between MRSA CC398-IIa-infected patients with and without livestock exposure. These findings suggest substantial dissemination of MRSA CC398-IIa from livestock or livestock workers into the Danish community and underscore the need for strategies to control its spread both on and off the farm.

Published
2015

3. Energy efficient engine: Low-pressure turbine subsonic cascade component development and integration program

Author

Sharma, O. P, Kopper, F. C, Knudsen, L. K, and Yustinich, J. B

Subjects
Aircraft Propulsion And Power
Abstract

A subsonic cascade test program was conducted to provide technical data for optimizing the blade and vane airfoil designs for the Energy Efficient Engine Low-Pressure Turbine component. The program consisted of three parts. The first involved an evaluation of the low-chamber inlet guide vane. The second, was an evaluation of two candidate aerodynamic loading philosophies for the fourth blade root section. The third part consisted of an evaluation of three candidate airfoil geometries for the fourth blade mean section. The performance of each candidate airfoil was evaluated in a linear cascade configuration. The overall results of this study indicate that the aft-loaded airfoil designs resulted in lower losses which substantiated Pratt & Whitney Aircraft's design philosophy for the Energy Efficient Engine low-pressure turbine component.

Published
1982

5. A novel paired domain DNA recognition motif can mediate Pax2 repression of gene transcription.

Author

Håvik B, Ragnhildstveit E, Lorens JB, Saelemyr K, Fauske O, Knudsen LK, and Fjose A

Subjects
5' Untranslated Regions genetics, Animals, Base Sequence, Binding Sites, Cell Line, Cloning, Molecular, Consensus Sequence, Conserved Sequence, DNA Footprinting, DNA-Binding Proteins metabolism, Gene Expression Regulation genetics, Molecular Sequence Data, Oligodeoxyribonucleotides genetics, PAX2 Transcription Factor, Peptide Fragments genetics, RNA, Messenger metabolism, Transcription Factors metabolism, Transfection, Zebrafish, Zebrafish Proteins, DNA-Binding Proteins genetics, Repressor Proteins genetics, Transcription Factors genetics
Abstract

The paired domain (PD) is an evolutionarily conserved DNA-binding domain encoded by the Pax gene family of developmental regulators. The Pax proteins are transcription factors and are involved in a variety of processes such as brain development, patterning of the central nervous system (CNS), and B-cell development. In this report we demonstrate that the zebrafish Pax2 PD can interact with a novel type of DNA sequences in vitro, the triple-A motif, consisting of a heptameric nucleotide sequence G/CAAACA/TC with an invariant core of three adjacent adenosines. This recognition sequence was found to be conserved in known natural Pax5 repressor elements involved in controlling the expression of the p53 and J-chain genes. By identifying similar high affinity binding sites in potential target genes of the Pax2 protein, including the pax2 gene itself, we obtained further evidence that the triple-A sites are biologically significant. The putative natural target sites also provide a basis for defining an extended consensus recognition sequence. In addition, we observed in transformation assays a direct correlation between Pax2 repressor activity and the presence of triple-A sites. The results suggest that a transcriptional regulatory function of Pax proteins can be modulated by PD binding to different categories of target sequences., (Copyright 1999 Academic Press.)

Published
1999
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