Search

Your search keyword '"Kobayashi, Aya"' showing total 296 results
Start Over Author "Kobayashi, Aya" Publication Year Range Last 50 years
296 results on '"Kobayashi, Aya"'

1. Serum-Derived Macrophage-Activating Factor Exhibits Anti-Tumor Activity via M2-to-M1 Macrophage Reprogramming.

Author

Takara, Tsuyoshi, Takara, Rei, Kobayashi, Aya, Shirakata, Hina, Ambai, Shinobu, Shinohara, Yusei, and Uto, Yoshihiro

Subjects
NITRIC-oxide synthases, MACROPHAGE activation, DNA analysis, TUMOR microenvironment, ANTINEOPLASTIC agents
Abstract

Many anti-tumor effects of group-specific component-derived macrophage-activating factors (GcMAFs) have been reported; however, the specific mechanisms remain unclear. Controlling tumor-associated macrophages (TAMs) in the tumor microenvironment is essential for cancer treatment. This study assessed the role of GcMAF in macrophage activation, elucidated the mechanisms by which it exerts its anti-tumor effects, and determined its effects on TAMs in the tumor microenvironment. GcMAF-stimulated RAW264.7 macrophages and EMT6 breast tumor cells were co-cultured in a 0.4 µm pore cell culture insert, and gene and protein expression and cell viability were evaluated. DNA microarray analysis of GcMAF-stimulated RAW264.7 cells was conducted. The induction of M2 RAW264.7 cells by interleukin (IL)-4 and IL-13 was analyzed. GcMAF stimulation increased the tumor necrosis factor-α and inducible nitric oxide synthase mRNA and protein levels in RAW264.7 cells but decreased the viability of co-cultured EMT6 cells. Although the details of the receptor or signal pathway of GcMAF are still unclear, these results were confirmed in the M2 RAW264.7 cells, suggesting that GcMAF exerts anti-tumor effects by inducing the differentiation of macrophages into the M1 type and reprogramming M2 macrophages to the M1 type. The anti-tumor activity of GcMAF via M2-to-M1 macrophage reprogramming could aid in developing novel cancer immunotherapies. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

2. The Effect of Additional Silane Pre-Treatment on the Microtensile Bond Strength of Resin-Based Composite Post-and-Core Build-Up Material.

Author

Wu, Chia-Ying, Nakamura, Keigo, Miyashita-Kobayashi, Aya, Haruyama, Akiko, Yokoi, Yukiko, Kuroiwa, Akihiro, Yoshinari, Nobuo, and Kameyama, Atsushi

Subjects
WATER immersion, BOND strengths, SCANNING electron microscopy, FAILURE mode & effects analysis
Abstract

The aim of this study was to evaluate the effect of additional silane treatment on the immediate and aged microtensile bond strength (µTBS) between resin-based composite (RBC) post-and-core build-up material and an RBC CAD/CAM block. Twelve sample blocks (12 mm × 14 mm × 9 mm) were prepared using RBC post-and-core build-up material and were divided into six groups: Kerr Silane Primer (Sil) + OptiBond eXTRa Universal adhesive (EXA); OptiBond eXTRa Universal Primer (EXP) + EXA; Sil + OptiBond Universal (OBU); OBU; Sil + OptiBond Solo Plus (OSP); and OSP. Each treated sample was luted to a CAD/CAM block using an NX3 Nexus Third-Generation instrument. After storage in 37 °C water for 1 week, microspecimens were fabricated, and μTBS was tested immediately or after further immersion in water at 37 °C for 6 months. The failure mode of each specimen was determined using stereomicroscopy and scanning electron microscopy. For the immediate groups, no significant difference in µTBS was found between specimens with or without silane treatment for each adhesive (p > 0.05). For the aged groups, silane treatment significantly decreased µTBS for OptiBond eXTRa Universal (p < 0.05). Our findings indicate that additional silane treatment prior to the application of adhesive did not enhance µTBS. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Attempt to introduce a new educational program in the clinical clerkship of operative dentistry for 5th grade students, School of Dentistry,Matsumoto Dental University Part2.Simulation training of direct composite veneer restoration

Author

KOMACHIYA, MIHO, KOMATSU, SAHO, KOHDA, KUNIKO, NAKAMURA, KEIGO, OKUSE, YOSHIYUKI, UCHIKAWA, RYUTARO, WU, CHIA-YING, KOBAYASHI, AYA, and KAMEYAMA, ATSUSHI

Subjects
保存修復学, コンポジットレジンダイレクトべニア, アンケート
Abstract

Summary A simulation practice of direct composite veneer restoration was newly started during the clinical training period of the 5th year conservatory course of Matsumoto Dental University since the AY 2020. This manuscript presents an overview of the program and examines its educational effects based on the evaluation of an anonymous questionnaire by students who participated in the program in 2020. 72 students in total participated in the 5th year clinical internship in AY 2020, and the program was conducted 9 times for 8 students each in the Department of Operative Dentistry. After a lecture and demonstration by the instructor, four pairs of two students each were assigned to practice direct composite veneer restoration without tooth reduction by applying the layering technique. After the practice, a lecture on the technique,materials and equipment used was given, followed by exercises on the relevant questions of the National Dental Examination that were asked in the past. After the program, an anonymous questionnaire was administered to the participants regarding their level of knowledge of direct composite veneer restoration before and after the program and their self–evaluation of the completion of their practice. The response rate of the questionnaires was 100%. After the program, 68% of the respondents answered that they “understood the direct composite veneer restoration very well” and 31% answered that they “understood it somewhat well. None of the respondents answered that they “did not understand much” or “did not understand at all. When asked whether the contents of the program deepened their knowledge of operative dentistry, 83% of the respondents answered “Very effective” and 15% answered “Somewhat effective”, and none of the respondents answered “Not very effective” or “Not at all effective”. These results suggested that the program was effective in deepening the knowledge level of operative dentistry.

Published
2022

7. Changes in Gloss Alteration, Surface Roughness, and Color of Direct Dental Restorative Materials after Professional Dental Prophylaxis.

Author

Miyashita-Kobayashi, Aya, Haruyama, Akiko, Nakamura, Keigo, Wu, Chia-Ying, Kuroiwa, Akihiro, Yoshinari, Nobuo, and Kameyama, Atsushi

Subjects
DENTAL prophylaxis, DENTAL materials, SURFACE preparation, DENTAL care, MEASURING instruments, COLOR, SURFACE roughness
Abstract

In the context of optimizing dental care for patients who are elderly, the purpose of this in vitro study was to evaluate the surface gloss (with a micro-area gloss meter) of, surface roughness (with a compact surface roughness measuring instrument) of, and color change (with a dental colorimeter) in two commercially available injectable resin-based composites (Estelite Universal Flow (EUF) and Beautifil Flow Plus F00 (BFP)) as well as two glass–ionomer cements (GC Fuji II LC CAPSULE (FLC) and GC Fuji IX GP EXTRA CAPSULE (FGP)), before and after dental prophylaxis. After 24 h, the surfaces of each specimen were polished at 2500 rpm with a prophy brush (Mersage Brush, Shofu) and one-step prophylaxis paste (Prophy Paste Pro, Directa): under 100 or 300 gf load, and for 10 or 30 s, 4× cycles of cleaning. After mechanical cleaning, conditions were found for a significant reduction in the gloss level (EUF, BFP, or FLC; p < 0.05) and a significant increase in surface roughness (BFP; 300 gf load, 10 s × four cycles of cleaning). Overall, the longer time or higher prophylaxis load tended to decrease the surface gloss. However, the observed change in surface roughness varied between the restorative materials. There was no color change post-prophylaxis. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Data from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Author

Iiizumi, Megumi, primary, Bandyopadhyay, Sucharita, primary, Pai, Sudha K., primary, Watabe, Misako, primary, Hirota, Shigeru, primary, Hosobe, Sadahiro, primary, Tsukada, Taisei, primary, Miura, Kunio, primary, Saito, Ken, primary, Furuta, Eiji, primary, Liu, Wen, primary, Xing, Fei, primary, Okuda, Hiroshi, primary, Kobayashi, Aya, primary, and Watabe, Kounosuke, primary

Published
2023
Full Text
View/download PDF

9. Data from Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem–Like Cells with Macrophages and Stromal Cells

Author

Okuda, Hiroshi, primary, Kobayashi, Aya, primary, Xia, Bo, primary, Watabe, Misako, primary, Pai, Sudha K., primary, Hirota, Shigeru, primary, Xing, Fei, primary, Liu, Wen, primary, Pandey, Puspa R., primary, Fukuda, Koji, primary, Modur, Vishnu, primary, Ghosh, Arnab, primary, Wilber, Andrew, primary, and Watabe, Kounosuke, primary

Published
2023
Full Text
View/download PDF

10. Supplementary Methods, Figures 1-7, Tables 1-7 from Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem–Like Cells with Macrophages and Stromal Cells

Author

Okuda, Hiroshi, primary, Kobayashi, Aya, primary, Xia, Bo, primary, Watabe, Misako, primary, Pai, Sudha K., primary, Hirota, Shigeru, primary, Xing, Fei, primary, Liu, Wen, primary, Pandey, Puspa R., primary, Fukuda, Koji, primary, Modur, Vishnu, primary, Ghosh, Arnab, primary, Wilber, Andrew, primary, and Watabe, Kounosuke, primary

Published
2023
Full Text
View/download PDF

11. Supplementary Figure 1 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Author

Iiizumi, Megumi, primary, Bandyopadhyay, Sucharita, primary, Pai, Sudha K., primary, Watabe, Misako, primary, Hirota, Shigeru, primary, Hosobe, Sadahiro, primary, Tsukada, Taisei, primary, Miura, Kunio, primary, Saito, Ken, primary, Furuta, Eiji, primary, Liu, Wen, primary, Xing, Fei, primary, Okuda, Hiroshi, primary, Kobayashi, Aya, primary, and Watabe, Kounosuke, primary

Published
2023
Full Text
View/download PDF

12. Supplementary Figure 2 from RhoC Promotes Metastasis via Activation of the Pyk2 Pathway in Prostate Cancer

Author

Iiizumi, Megumi, primary, Bandyopadhyay, Sucharita, primary, Pai, Sudha K., primary, Watabe, Misako, primary, Hirota, Shigeru, primary, Hosobe, Sadahiro, primary, Tsukada, Taisei, primary, Miura, Kunio, primary, Saito, Ken, primary, Furuta, Eiji, primary, Liu, Wen, primary, Xing, Fei, primary, Okuda, Hiroshi, primary, Kobayashi, Aya, primary, and Watabe, Kounosuke, primary

Published
2023
Full Text
View/download PDF

18. 松本歯科大学歯学部第6学年保存修復学国家試験対策講義におけるオンライン型リアルタイム投票サービス『Mentimeter』の活用

Author

KAMEYAMA, ATSUSHI, MORI, HIROSHI, KOMACHIYA, MIHO, KOMATSU, SAHO, UCHIKAWA, RYUTARO, KOHDA, KUNIKO, OKUSE, TOSHIYUKI, KOBAYASHI, AYA, and WU, CHIA-YING

Subjects
Mentimeter, ICT教育, ComputingMilieux_COMPUTERSANDEDUCATION, 双方向授業
Abstract

Summary Many attempts to utilize ICT (Information and Communication Technology) tools have been made to promote active and interactive learning between teachers and students. A major area has been the introduction of education using clickers for dental students, and some reports indicated their effects. However, the introduction of mobile devices and software and their maintenance and management very costly. On the other hand, almost allundergraduate students of Matsumoto Dental University have a smartphone, and can connect to the Internet in the lecture room. Therefore, we conducted online exercises to pre- pare for the National Board Dental Examination using students’ smartphones and the online real–time voting service“Mentimeter” at the lecture of Operative Dentistry for 6th–year dental students of Matsumoto Dental University, in the school year of 2019. We also conducted some anonymous online questionnaires using Mentimeter. Thirty percent of the participating students answered that they were not good at conservation and restoration studies. Although 97% of students answered that the test questions conducted in the exercise using Mentimeter were difficult, 92% of the students answered that the exercise was effective in deepening their knowledge of Operative Dentistry. The results of the questionnaires suggested the effectiveness of the interactive lecture using Mentimeter in order to deepen and retain knowledge of Operative Dentistry.

Published
2021

34. CCR4-positive peripheral T-cell lymphoma presenting as eosinophilic pneumonia and developing from prolonged pustular psoriasis

Author

Sekiguchi, Nodoka, primary, Komatsu, Masamichi, additional, Ichiyama, Takashi, additional, Kobayashi, Aya, additional, Gomi, Daisuke, additional, Fukushima, Toshirou, additional, Kobayashi, Takashi, additional, Noguchi, Takuro, additional, Nakazawa, Hideyuki, additional, Asano, Naoko, additional, Ishida, Fumihiro, additional, and Koizumi, Tomonobu, additional

Published
2021
Full Text
View/download PDF

45. Abstract A146: Systematic discovery of immune regulatory mechanisms in tumor cells

Author

Pan, Deng, primary, Kobayashi, Aya, additional, Jiang, Peng, additional, Yuan, Guo-Cheng, additional, Liu, X. Shirley, additional, Doench, John, additional, Qiu, Xintao, additional, Rao, Prakash, additional, Long, Henry, additional, Brown, Myles A., additional, Wucherpfennig, Kai W., additional, Andrade, Lucas Ferrari de, additional, Tay, Rong En, additional, Luoma, Adrienne M., additional, Tsoucas, Daphne, additional, and Lim, Klothilda, additional

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results