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951 results on '"Lalu, Manoj"'

1. Use of opioids and opioid alternatives during general anesthesia: a pan-Canadian survey among anesthesiologists: Use of opioids and opioid alternatives during anesthesia

Author

Verret, Michael, Lalu, Manoj M., Assi, Alexandre, Nicholls, Stuart G., Turgeon, Alexis F., Carrier, Francois M., McIsaac, Daniel I., Gilron, Ian, Zikovic, Fiona, Graham, Megan, Lê, Maxime, Geist, Allison, Martel, Guillaume, McVicar, Jason A., Moloo, Husein, and Fergusson, Dean

Published
2024
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2. Home-based exercise prehabilitation to improve disease-free survival and return to intended oncologic treatment after cancer surgery in older adults with frailty: a secondary analysis of a randomized trial

Author

McIsaac, Daniel I., Neilipovitz, Nathaniel, Bryson, Gregory L., Gagne, Sylvain, Huang, Allen, Lalu, Manoj, Lavallée, Luke T., Moloo, Husein, Power, Barbara, Scheede-Bergdahl, Celena, van Walraven, Carl, McCartney, Colin J. L., Taljaard, Monica, and Hladkowicz, Emily

Published
2024
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6. Delphi-driven consensus definition for mesenchymal stromal cells and clinical reporting guidelines for mesenchymal stromal cell–based therapeutics

Author

Renesme, Laurent, Cobey, Kelly D., Lalu, Manoj M., Bubela, Tania, Chinnadurai, Raghavan, De Vos, John, Dunbar, Rod, Fergusson, Dean, Freund, Daniel, Galipeau, Jacques, Horwitz, Edwin, Lê, Maxime, Matthay, Michael, Moher, David, Nolta, Jan, Parker, Graham, Phinney, Donald G., Rao, Mahendra, Rasko, John E.J., Rocco, Patricia R.M., Rossi, Fabio, Myles, Michael Rosu, Viswanathan, Sowmya, and Thébaud, Bernard

Published
2025
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10. Effectiveness of dexmedetomidine on patient-centred outcomes in surgical patients: a systematic review and Bayesian meta-analysis

Author

Verret, Michael, Le, John B.P., Lalu, Manoj M., Jeffers, Matthew S., McIsaac, Daniel I., Nicholls, Stuart G., Turgeon, Alexis F., Ramchandani, Rashi, Li, Hongda, Hutton, Brian, Zivkovic, Fiona, Graham, Megan, Lê, Maxime, Geist, Allison, Bérubé, Mélanie, O'Hearn, Katie, Gilron, Ian, Poulin, Patricia, Daudt, Helena, Martel, Guillaume, McVicar, Jason, Moloo, Husein, and Fergusson, Dean A.

Published
2024
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11. Economic Evaluations of Chimeric Antigen Receptor T-Cell Therapies for Hematologic and Solid Malignancies: A Systematic Review

Author

Thavorn, Kednapa, Thompson, Emily Rose, Kumar, Srishti, Heiskanen, Aliisa, Agarwal, Anubhav, Atkins, Harold, Shorr, Risa, Hawrysh, Terry, Chan, Kelvin Kar-Wing, Presseau, Justin, Ollendorf, Daniel A., Graham, Ian D., Grimshaw, Jeremy M., Lalu, Manoj Mathew, Nochaiwong, Surapon, Fergusson, Dean A., Hutton, Brian, Coyle, Doug, and Kekre, Natasha

Published
2024
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14. Intraoperative pharmacologic opioid minimisation strategies and patient-centred outcomes after surgery: a scoping review

Author

Verret, Michael, Lam, Nhat H., Lalu, Manoj, Nicholls, Stuart G., Turgeon, Alexis F., McIsaac, Daniel I., Hamtiaux, Myriam, Bao Phuc Le, John, Gilron, Ian, Yang, Lucy, Kaimkhani, Mahrukh, Assi, Alexandre, El-Adem, David, Timm, Makenna, Tai, Peter, Amir, Joelle, Srichandramohan, Sriyathavan, Al-Mazidi, Abdulaziz, Fergusson, Nicholas A., Hutton, Brian, Zivkovic, Fiona, Graham, Megan, Lê, Maxime, Geist, Allison, Bérubé, Mélanie, Poulin, Patricia, Shorr, Risa, Daudt, Helena, Martel, Guillaume, McVicar, Jason, Moloo, Husein, and Fergusson, Dean A.

Published
2024
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17. Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions

Author

Sharma, Neha, Chwastek, Damian, Dwivedi, Dhruva J., Schlechte, Jared, Yu, Ian-Ling, McDonald, Braedon, Arora, Jaskirat, Cani, Erblin, Eng, Mikaela, Engelberts, Doreen, Kuhar, Eva, Medeiros, Sarah K., Bourque, Stephane L., Cepinskas, Gediminas, Gill, Sean E., Jahandideh, Forough, Macala, Kimberly F., Panahi, Sareh, Pape, Cynthia, Sontag, David, Sunohara-Neilson, Janet, Fergusson, Dean A., Fox-Robichaud, Alison E., Liaw, Patricia C., Lalu, Manoj M., and Mendelson, Asher A.

Published
2023
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23. An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue–derived MSCs for research purposes

Author

Viswanathan, Sowmya, Blanc, Katarina Le, Ciccocioppo, Rachele, Dagher, Georges, Filiano, Anthony J., Galipeau, Jacques, Krampera, Mauro, Krieger, Lena, Lalu, Manoj M., Nolta, Jan, Rodriguez Pardo, Viviana Marcela, Shi, Yufang, Tarte, Karin, Weiss, Daniel J., and Martin, Ivan

Published
2023
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24. Systematic reviews and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: mortality, morbidity, and organ failure

Author

Myles, Paul, Gan, T.J., Kurz, Andrea, Peyton, Phil, Sessler, Dan, Tramèr, Martin, Cyna, Alan, De Oliveira, Gildasio S., Jr., Wu, Christopher, Jensen, Mark, Kehlet, Henrik, Botti, Mari, Boney, Oliver, Haller, Guy, Grocott, Mike, Cook, Tim, Fleisher, Lee, Neuman, Mark, Story, David, Gruen, Russell, Bampoe, Sam, Evered, Lis, Scott, David, Silbert, Brendan, van Dijk, Diederik, Kalkman, Cor, Chan, Matthew, Grocott, Hilary, Eckenhoff, Rod, Rasmussen, Lars, Eriksson, Lars, Beattie, Scott, Wijeysundera, Duminda, Landoni, Giovanni, Leslie, Kate, Biccard, Bruce, Howell, Simon, Nagele, Peter, Richards, Toby, Lamy, Andre, Lalu, Manoj, Pearse, Rupert, Mythen, Monty, Canet, Jaume, Moller, Ann, Gin, Tony, Schultz, Marcus, Pelosi, Paolo, Gabreu, Marcelo, Futier, Emmanuel, Creagh-Brown, Ben, Abbot, Tom, Klein, Andy, Corcoran, Tomas, Cooper, D. Jamie, Dieleman, Stefan, Diouf, Elisabeth, McIlroy, David, Bellomo, Rinaldo, Shaw, Andrew, Prowle, John, Karkouti, Keyvan, Billings, Josh, Mazer, David, Jayarajah, Mohindas, Murphy, Michael, Bartoszko, Justyna, Sneyd, Rob, Morris, Steve, George, Ron, Moonesinghe, Ramani, Shulman, Mark, Lane-Fall, Meghan, Nilsson, Ulrica, Stevenson, Nathalie, van Klei, Wilton, Cabrini, Luca, Miller, Tim, Jackson, Sandy, Buggy, Donal, Short, Tim, Riedel, Bernhard, Gottumukkala, Vijay, Pace, Nathan, Alkhaffaf, Bilal, Johnson, Mark, Jackson, Alexander I.R., Pearse, Rupert M., Cooper, D. James, van Klei, Wilton A., Miller, Timothy E., Moonesinghe, S. Ramani, Myles, Paul S., and Grocott, Michael P.W.

Published
2023
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26. High-Sensitivity Cardiac Troponin I Thresholds to Identify Myocardial Injury After Noncardiac Surgery: A Cohort Study

Author

Duceppe, Emmanuelle, Borges, Flavia K., Tiboni, Maria, Pearse, Rupert, Chan, Matthew T.V., Srinathan, Sadeesh, Kavsak, Peter A., Garg, Amit X., Sessler, Daniel I., Sapsford, Robert, Heels-Ansdell, Diane, Pettit, Shirley, Vasquez, Javiera, Mueller, Christian, Walsh, Micheal, Szczeklik, Wojciech, Rodseth, Reitze, Lalu, Manoj, Thabane, Lehana, Guyatt, Gordon, and Devereaux, P.J.

Published
2023
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36. A scoping review protocol on brain PaCO2 levels at altitude.

Author

Tang, Hanna, Charlesworth, Laurel, Lalu, Manoj, Dewar, Brian, Shorr, Risa, and Dowlatshahi, Dariush

Subjects
MEDICAL periodicals, ISCHEMIC stroke, CEREBRAL ischemia, TRANSPORTATION rates, STROKE
Abstract

Background: Aeromedical transfer of patients with ischemic stroke to access hyperacute stroke treatment is becoming increasingly common. Little is known about how rapid changes of altitude and atmospheric pressure can impact cerebral perfusion and ischemic burden. In patients with ischemic stroke, there is a theoretical possibility that this physiologic response of hypoxia-driven hyperventilation at higher altitude can lead to a relative drop in PaCO2. This would ultimately result in cerebral vasoconstriction, and therefore worsening of the ischemic burden in patients with ischemic stroke. Currently, there are no specific recommendations in stroke guidelines for optimizing altitude of aeromedical transportation to minimize the rate of ischemic burden. In this scoping review, we aim to map the available literature that addressed whether PaCO2 changes with altitude. This would be the steppingstone for more in-depth analyses into the cerebral autoregulatory consequences of high altitude on cerebral ischemia to form future guidelines. Methods and analysis: We will follow scoping review methods recommended by the Joanna Briggs Institute. Electronic databases MEDLINE, Embase, Web of Science, and Cochrane Central Register of Systematic will be systematically searched to identify articles that report on the acute response of PaCO2 on acute change in altitude. Two independent investigators will perform duplicate title and abstract screening and full-text review, followed by duplicate data extraction. We will present quantitative data using descriptive statistics. Key textual information will be synthesized in a tabular format Simple statistics on the frequency of papers, data will be presented via histogram. Ethics and dissemination: This scoping review does not require ethical approval. The results of our scoping review will be published in academic medical journals and presented at medical conferences. The findings will highlight the current availability of literature on PaCO2 changes with altitude. Registration: This scoping review protocol has been registered in Open Science Framework (DOI 10.17605/OSF.IO/UVK83). [ABSTRACT FROM AUTHOR]

Published
2025
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37. Investigating the trustworthiness of research evidence used to inform public health policy: a qualitative interview study on the use of predatory journal citations in policy documents.

Author

Albert, Marc A., Lalu, Manoj M., and Grudniewicz, Agnes

Subjects
*HEALTH policy, *PREDATORY publishing, *EVIDENCE-based policy, *PUBLIC health, *HUMAN services
Abstract

Evidence-based policymaking has increased policymakers' capacity to make scientifically informed health policy decisions. However, reaping the benefits of this approach requires avoiding untrustworthy research – potential sources of which are predatory journals. In this study, we sought to understand how research cited in policy documents is sourced and evaluated, and identify factors that may be contributing to the citation of predatory journals or other less trustworthy evidence. To this end, we conducted semi-structured interviews with individuals who have prepared public health policy documents. These interviews were thematically analysed, and five key overarching themes were generated regarding the process of deciding how to develop policy documents (e.g. which individuals to involve) and how this may impact which information is included; obstacles such as limited evidence that may hinder policy document development; and concerns around transparency throughout the development process. Our findings highlight that in many cases, information cited in policy documents is sourced and evaluated with variable rigour. This may contribute to the citation of untrustworthy research in policy documents. Certain steps can be taken to help minimize any potential negative impact of relying on such sources (e.g. improving transparency), but a better understanding of policymakers' perspectives regarding how taking these steps would impact their decision-making process may be required to ensure successful implementation. [ABSTRACT FROM AUTHOR]

Published
2025
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38. Systematic review of microRNAs in human acute kidney injury.

Author

Douvris, Adrianna, Viñas, Jose L., Akbari, Shareef, Tailor, Karishma, Lalu, Manoj M., Burger, Dylan, and Burns, Kevin D.

Abstract

Early diagnosis of acute kidney injury (AKI) is limited with current tools. MicroRNAs (miRNAs) are implicated in AKI pathogenesis in preclinical models, but less is known about their role in humans. We conducted a systematic review to identify dysregulated miRNAs in humans with AKI. We searched Ovid MEDLINE, Embase, Web of Science, and CENTRAL (August 21, 2023) for studies of human subjects with AKI. We excluded reviews and pre-clinical studies without human data. The primary outcome was dysregulated miRNAs in AKI. Two reviewers screened abstracts, reviewed full texts, performed data extraction and quality assessment (Newcastle Ottawa Scale). We screened 2,456 reports and included 92 for synthesis without meta-analysis. All studies except one were observational. Studies were grouped by etiology of AKI: cardiac surgery-associated (CS-AKI, n = 13 studies), sepsis (n = 25), nephrotoxic (n = 9), kidney transplant (n = 26), and other causes (n = 19). In total, 128 miRNAs were identified to be dysregulated across AKI studies (45 miRNAs upregulated, 55 downregulated, 28 both). miR-21 was the most frequently reported (n = 17 studies) and it was increased in all etiologies except CS-AKI where it was decreased (n = 3 studies). Study limitations included bias due to targeted approaches, absence of clinical data/controls, and miRNA normalization methods. Overall study quality was fair (median 5/9, range 2-8 points). Dysregulated miRNAs, particularly miR-21, have potential as AKI biomarkers. These results should be interpreted cautiously due to methodological limitations. Standardized methods and unbiased approaches are needed to validate candidate miRNA biomarkers. Registration: International Prospective Register of Systematic Reviews (PROSPERO CRD42020201253) [ABSTRACT FROM AUTHOR]

Published
2024
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47. Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature.

Author

Fergusson, Dean A, Avey, Marc T, Barron, Carly C, Bocock, Mathew, Biefer, Kristen E, Boet, Sylvain, Bourque, Stephane L, Conic, Isidora, Chen, Kai, Dong, Yuan Yi, Fox, Grace M, George, Ronald B, Goldenberg, Neil M, Gragasin, Ferrante S, Harsha, Prathiba, Hong, Patrick J, James, Tyler E, Larrigan, Sarah M, MacNeil, Jenna L, Manuel, Courtney A, Maximos, Sarah, Mazer, David, Mittal, Rohan, McGinn, Ryan, Nguyen, Long H, Patel, Abhilasha, Richebé, Philippe, Saha, Tarit K, Steinberg, Benjamin E, Sampson, Sonja D, Stewart, Duncan J, Syed, Summer, Vella, Kimberly, Wesch, Neil L, Lalu, Manoj M, and Canadian Perioperative Anesthesia Clinical Trials Group

Subjects
Canadian Perioperative Anesthesia Clinical Trials Group, Animals, Pain, Analgesics, Drug Evaluation, Preclinical, Databases, Factual, Guidelines as Topic, Research Report, Databases, Factual, Drug Evaluation, Preclinical, General Science & Technology
Abstract

Poor reporting quality may contribute to irreproducibility of results and failed 'bench-to-bedside' translation. Consequently, guidelines have been developed to improve the complete and transparent reporting of in vivo preclinical studies. To examine the impact of such guidelines on core methodological and analytical reporting items in the preclinical anesthesiology literature, we sampled a cohort of studies. Preclinical in vivo studies published in Anesthesiology, Anesthesia & Analgesia, Anaesthesia, and the British Journal of Anaesthesia (2008-2009, 2014-2016) were identified. Data was extracted independently and in duplicate. Reporting completeness was assessed using the National Institutes of Health Principles and Guidelines for Reporting Preclinical Research. Risk ratios were used for comparative analyses. Of 7615 screened articles, 604 met our inclusion criteria and included experiments reporting on 52 490 animals. The most common topic of investigation was pain and analgesia (30%), rodents were most frequently used (77%), and studies were most commonly conducted in the United States (36%). Use of preclinical reporting guidelines was listed in 10% of applicable articles. A minority of studies fully reported on replicates (0.3%), randomization (10%), blinding (12%), sample-size estimation (3%), and inclusion/exclusion criteria (5%). Statistics were well reported (81%). Comparative analysis demonstrated few differences in reporting rigor between journals, including those that endorsed reporting guidelines. Principal items of study design were infrequently reported, with few differences between journals. Methods to improve implementation and adherence to community-based reporting guidelines may be necessary to increase transparent and consistent reporting in the preclinical anesthesiology literature.

Published
2019

48. Prehabilitation in adult patients undergoing surgery: an umbrella review of systematic reviews

Author

Akhtar, Shamsuddin, Atkins, Marlis, Aucoin, Sylvie, Auer, Rebecca, Basualdo-Hammond, Carlota, Beaule, Paul, Brindle, Mary, Bittner, Honorata, Bryson, Gregory, Carli, Franco, Eskander, Antoine, Fata, Paola, Fergusson, Dean, Fiore, Julio, Jr., Forster, Alan, Gillam, Melani, Gramlich, Leah, Holroyd-Leduc, Jayna, Jackson, Timothy, Jacobsohn, Eric, Khadaroo, Rachel, Lalu, Manoj, Love, Cameron, Martel, Guillaume, McCartney, Colin, McKeen, Dolores, Meliambro, Amanda, Moloo, Husein, Moore, Ronald, Muscedere, John, Nantel, Julie, Poitras, Stephane, Scheede-Bergdahl, Celena, Taljaard, Monica, Wallace, Tom, Wijeysundera, Duminda, McIsaac, Daniel I., Gill, Marlyn, Boland, Laura, Hutton, Brian, Branje, Karina, Shaw, Julia, Grudzinski, Alexa L., Barone, Natasha, and Gillis, Chelsia

Published
2022
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