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Your search keyword '"Lalu, Manoj M."' showing total 639 results
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639 results on '"Lalu, Manoj M."'

4. Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions

Author

Sharma, Neha, Chwastek, Damian, Dwivedi, Dhruva J., Schlechte, Jared, Yu, Ian-Ling, McDonald, Braedon, Arora, Jaskirat, Cani, Erblin, Eng, Mikaela, Engelberts, Doreen, Kuhar, Eva, Medeiros, Sarah K., Bourque, Stephane L., Cepinskas, Gediminas, Gill, Sean E., Jahandideh, Forough, Macala, Kimberly F., Panahi, Sareh, Pape, Cynthia, Sontag, David, Sunohara-Neilson, Janet, Fergusson, Dean A., Fox-Robichaud, Alison E., Liaw, Patricia C., Lalu, Manoj M., and Mendelson, Asher A.

Published
2023
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23. Reporting preclinical anesthesia study (REPEAT): Evaluating the quality of reporting in the preclinical anesthesiology literature.

Author

Fergusson, Dean A, Avey, Marc T, Barron, Carly C, Bocock, Mathew, Biefer, Kristen E, Boet, Sylvain, Bourque, Stephane L, Conic, Isidora, Chen, Kai, Dong, Yuan Yi, Fox, Grace M, George, Ronald B, Goldenberg, Neil M, Gragasin, Ferrante S, Harsha, Prathiba, Hong, Patrick J, James, Tyler E, Larrigan, Sarah M, MacNeil, Jenna L, Manuel, Courtney A, Maximos, Sarah, Mazer, David, Mittal, Rohan, McGinn, Ryan, Nguyen, Long H, Patel, Abhilasha, Richebé, Philippe, Saha, Tarit K, Steinberg, Benjamin E, Sampson, Sonja D, Stewart, Duncan J, Syed, Summer, Vella, Kimberly, Wesch, Neil L, Lalu, Manoj M, and Canadian Perioperative Anesthesia Clinical Trials Group

Subjects
Canadian Perioperative Anesthesia Clinical Trials Group, Animals, Pain, Analgesics, Drug Evaluation, Preclinical, Databases, Factual, Guidelines as Topic, Research Report, Databases, Factual, Drug Evaluation, Preclinical, General Science & Technology
Abstract

Poor reporting quality may contribute to irreproducibility of results and failed 'bench-to-bedside' translation. Consequently, guidelines have been developed to improve the complete and transparent reporting of in vivo preclinical studies. To examine the impact of such guidelines on core methodological and analytical reporting items in the preclinical anesthesiology literature, we sampled a cohort of studies. Preclinical in vivo studies published in Anesthesiology, Anesthesia & Analgesia, Anaesthesia, and the British Journal of Anaesthesia (2008-2009, 2014-2016) were identified. Data was extracted independently and in duplicate. Reporting completeness was assessed using the National Institutes of Health Principles and Guidelines for Reporting Preclinical Research. Risk ratios were used for comparative analyses. Of 7615 screened articles, 604 met our inclusion criteria and included experiments reporting on 52 490 animals. The most common topic of investigation was pain and analgesia (30%), rodents were most frequently used (77%), and studies were most commonly conducted in the United States (36%). Use of preclinical reporting guidelines was listed in 10% of applicable articles. A minority of studies fully reported on replicates (0.3%), randomization (10%), blinding (12%), sample-size estimation (3%), and inclusion/exclusion criteria (5%). Statistics were well reported (81%). Comparative analysis demonstrated few differences in reporting rigor between journals, including those that endorsed reporting guidelines. Principal items of study design were infrequently reported, with few differences between journals. Methods to improve implementation and adherence to community-based reporting guidelines may be necessary to increase transparent and consistent reporting in the preclinical anesthesiology literature.

Published
2019

26. A qualitative evaluation of treatment fidelity alongside a pilot trial of a novel therapy for pediatric Inflammatory Bowel Disease.

Author

Olson, Jenny L., Castillo, Gisell, Palumbo, Amelia, Harrison, Megan, Singleton, Ruth, Lalu, Manoj M., Fergusson, Dean A., Stintzi, Alain, Mack, David R., and Presseau, Justin

Subjects
INFLAMMATORY bowel diseases, GUT microbiome, PEDIATRIC therapy, STUDENT activities, SEMI-structured interviews
Abstract

Background: Process evaluations conducted alongside clinical trials can improve understanding of treatment fidelity and provide contextual knowledge to aide interpretations of trial outcomes. We adopted a multiple-goals perspective to investigate treatment fidelity in two related pilot clinical trials of an adjuvant treatment for pediatric-onset Inflammatory Bowel Disease. This included a focus on barriers and enablers of performing trial-specific activities and of integrating those activities into daily life. Methods: We conducted one-time semi-structured interviews with a sub-sample of participants of the Resistant Starch in Pediatric Inflammatory Bowel Disease (NCT04522271) and Optimized Resistant Starch in Inflammatory Bowel Disease pilot trials (NCT04520594) and their caregivers (N = 42). The trials examined the effects of personalized food-derived resistant starches as an adjuvant therapy on intestinal microbiome functioning. Interviews were conducted within 3-months of participants completing or withdrawing from the trials. Interview guides with age-appropriate language were developed and pilot tested. Codes were identified inductively though conventional content analysis and then mapped to personal projects analysis, to explore how participants navigated between activities. Results: Three themes were identified. The first described the potential impact of living with inflammatory bowel disease and taking prescribed medications. The second described characteristics of trial-specific activities that might impact on their enactment, including perceived difficulty, and challenges following procedures or using trial materials. The third described the integration of trial-specific activities with school, work, household demands, and social, and extracurricular activities. Conclusions: Adjusting to living with inflammatory bowel disease and managing its treatment can impact trial participation. Integrating trial-related activities into daily life can be challenging, which could heighten perceptions of goal conflict. Findings can inform interpretations of trial outcomes and development of strategies for trial optimization and implementation of the adjuvant therapy into clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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27. A preclinical systematic review and meta-analysis assessing the effect of biological sex in lipopolysaccharide-induced acute lung injury.

Author

Kuhar, Eva, Chander, Nikesh, Stewart, Duncan J., Jahandideh, Forough, Haibo Zhang, Kristof, Arnold S., Bastarache, Julie A., Schmidt, Eric P., Taljaard, Monica, Thebaud, Bernard, Engelberts, Doreen, Fergusson, Dean A., and Lalu, Manoj M.

Subjects
SEX (Biology), LUNG injuries, LIPOPOLYSACCHARIDES
Abstract

It is unclear what effect biological sex has on outcomes of acute lung injury (ALI). Clinical studies are confounded by their observational design. We addressed this knowledge gap with a preclinical systematic review of ALI animal studies. We searched MEDLINE and Embase for studies of intratracheal/intranasal/aerosolized lipopolysaccharide administration (the most common ALI model) that reported sex-stratified data. Screening and data extraction were conducted in duplicate. Our primary outcome was histological tissue injury and secondary outcomes included alveolar-capillary barrier alterations and inflammatory markers. We used a random-effects inverse variance meta-analysis, expressing data as standardized mean difference (SMD) with 95% confidence intervals (CIs). Risk of bias was assessed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. We identified six studies involving 132 animals across 11 independent experiments. A total of 41 outcomes were extracted, with the direction of effect suggesting greater severity in males than females in 26/41 outcomes (63%). One study reported on lung histology and found that male mice exhibited greater injury than females (SMD: 1.61, 95% CI: 0.53–2.69). Meta-analysis demonstrated significantly elevated albumin levels (SMD: 2.17, 95% CI: 0.63–3.70) and total cell counts (SMD: 0.80, 95% CI: 0.27–1.33) in bronchoalveolar lavage fluid from male mice compared with female mice. Most studies had an “unclear risk of bias.” Our findings suggest sex-related differences in ALI severity. However, these conclusions are drawn from a small number of animals and studies. Further research is required to address the fundamental issue of biological sex differences in LPS-induced ALI. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Effectiveness of dexmedetomidine during surgery under general anaesthesia on patient-centred outcomes: a systematic review and Bayesian meta-analysis protocol

Author

Verret, Michael, primary, Le, John Bao Phuc, additional, Lalu, Manoj M, additional, McIsaac, Daniel I, additional, Nicholls, Stuart, additional, Turgeon, Alexis F, additional, Hutton, Brian, additional, Zivkovic, Fiona, additional, Graham, Megan, additional, Le, Maxime, additional, Geist, Allison, additional, Berube, Melanie, additional, Gilron, Ian, additional, Poulin, Patricia, additional, Daudt, Helena, additional, Martel, Guillaume, additional, McVicar, Jason, additional, Moloo, Husein, additional, and Fergusson, Dean A, additional

Published
2024
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31. Declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas

Author

Yepes-Nuñez, Juan José, Urrútia, Gerard, Romero-García, Marta, Alonso-Fernández, Sergio, Page, Matthew J., McKenzie, Joanne E., Bossuyt, Patrick M., Boutron, Isabelle, Hoffmann, Tammy C., Mulrow, Cynthia D., Shamseer, Larissa, Tetzlaff, Jennifer M., Akl, Elie A., Brennan, Sue E., Chou, Roger, Glanville, Julie, Grimshaw, Jeremy M., Hróbjartsson, Asbjørn, Lalu, Manoj M., Li, Tianjing, Loder, Elizabeth W., Mayo-Wilson, Evan, McDonald, Steve, McGuinness, Luke A., Stewart, Lesley A., Thomas, James, Tricco, Andrea C., Welch, Vivian A., Whiting, Penny, and Moher, David

Published
2021
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33. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews

Author

Page, Matthew J., McKenzie, Joanne E., Bossuyt, Patrick M., Boutron, Isabelle, Hoffmann, Tammy C., Mulrow, Cynthia D., Shamseer, Larissa, Tetzlaff, Jennifer M., Akl, Elie A., Brennan, Sue E., Chou, Roger, Glanville, Julie, Grimshaw, Jeremy M., Hróbjartsson, Asbjørn, Lalu, Manoj M., Li, Tianjing, Loder, Elizabeth W., Mayo-Wilson, Evan, McDonald, Steve, McGuinness, Luke A., Stewart, Lesley A., Thomas, James, Tricco, Andrea C., Welch, Vivian A., Whiting, Penny, and Moher, David

Published
2021
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42. Safety and Efficacy of Adeno-Associated Viral Gene Therapy in Patients With Retinal Degeneration: A Systematic Review and Meta-Analysis

Author

Sobh, Mohamad, primary, Lagali, Pamela S., additional, Ghiasi, Maryam, additional, Montroy, Joshua, additional, Dollin, Michael, additional, Hurley, Bernard, additional, Leonard, Brian C., additional, Dimopoulos, Ioannis, additional, Lafreniere, Mackenzie, additional, Fergusson, Dean A., additional, Lalu, Manoj M., additional, and Tsilfidis, Catherine, additional

Published
2023
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