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1,019 results on '"Lartigau, E."'

1. Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC Group

Author

Lacas, Benjamin, Carmel, Alexandra, Landais, Cécile, Wong, Stuart J, Licitra, Lisa, Tobias, Jeffrey S, Burtness, Barbara, Ghi, Maria Grazia, Cohen, Ezra EW, Grau, Cai, Wolf, Gregory, Hitt, Ricardo, Corvò, Renzo, Budach, Volker, Kumar, Shaleen, Laskar, Sarbani Ghosh, Mazeron, Jean-Jacques, Zhong, Lai-Ping, Dobrowsky, Werner, Ghadjar, Pirus, Fallai, Carlo, Zakotnik, Branko, Sharma, Atul, Bensadoun, René-Jean, Redda, Maria Grazia Ruo, Racadot, Séverine, Fountzilas, George, Brizel, David, Rovea, Paolo, Argiris, Athanassios, Nagy, Zoltán Takácsi, Lee, Ju-Whei, Fortpied, Catherine, Harris, Jonathan, Bourhis, Jean, Aupérin, Anne, Blanchard, Pierre, Pignon, Jean-Pierre, Group, MACH-NC Collaborative, Adelstein, DJ, Alfonsi, M, Belkacemi, Y, Bar-Ad, V, Bernier, J, Bratland, Å, Calais, G, Campbell, B, Caudell, J, Chabaud, S, Chamorey, E, Chaukar, D, Choi, KN, Choussy, O, Collette, L, Cruz, JJ, Dani, C, Dauzier, E, Forastiere, AA, Garaud, P, Gregoire, V, Hackshaw, A, Haddad, E, Haffty, BG, Hansen, A, Hayoz, S, Horiot, JC, Jeremic, B, Karrison, TG, Langendijk, JA, Lapeyre, M, Lartigau, E, Leong, T, Le, QT, Lee, PPY, Lewin, F, Lin, A, Lopes, A, Mehta, S, Moon, J, Moyal, E, Occéan, BV, Olmi, P, Orecchia, R, O'Sullivan, B, Overgaard, J, Petit, C, Quon, H, Sanguineti, G, Satar, T, Simes, J, Simon, C, Sire, C, Staar, S, Stromberger, C, Strojan, P, Temam, S, Thomson, D, Timochenko, A, Torri, V, and Tseroni, V

Subjects
Cancer, Clinical Trials and Supportive Activities, Rare Diseases, Clinical Research, 6.5 Radiotherapy and other non-invasive therapies, Evaluation of treatments and therapeutic interventions, Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Squamous Cell, Chemotherapy, Adjuvant, Head and Neck Neoplasms, Humans, Induction Chemotherapy, Randomized Controlled Trials as Topic, Meta-analysis, Review, Individual Patient Data, Randomised Clinical Trials, Chemotherapy, Radiotherapy, Head and Neck Cancer, MACH-NC Collaborative Group, Other Physical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Background and purposeThe Meta-Analysis of Chemotherapy in squamous cell Head and Neck Cancer (MACH-NC) demonstrated that concomitant chemotherapy (CT) improved overall survival (OS) in patients without distant metastasis. We report the updated results.Materials and methodsPublished or unpublished randomized trials including patients with non-metastatic carcinoma randomized between 1965 and 2016 and comparing curative loco-regional treatment (LRT) to LRT + CT or adding another timing of CT to LRT + CT (main question), or comparing induction CT + radiotherapy to radiotherapy + concomitant (or alternating) CT (secondary question) were eligible. Individual patient data were collected and combined using a fixed-effect model. OS was the main endpoint.ResultsFor the main question, 101 trials (18951 patients, median follow-up of 6.5 years) were analyzed. For both questions, there were 16 new (2767 patients) and 11 updated trials. Around 90% of the patients had stage III or IV disease. Interaction between treatment effect on OS and the timing of CT was significant (p

Published
2021

4. Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial

Author

Lartigau, E, Patton, S, Thompson, A, Winkler, M, Wells, P, Lymberiou, T, Saunders, D, Vilarino-Varela, M, Vavassis, P, Tsakiridis, T, Carlson, R, Rodrigues, G, Tanguay, J, Iqbal, S, Morgan, S, Mihai, A, Li, A, Din, O, Panades, M, Wade, R, Rimmer, Y, Oommen, N, Tree, Alison C, Ostler, Peter, van der Voet, Hans, Chu, William, Loblaw, Andrew, Ford, Daniel, Tolan, Shaun, Jain, Suneil, Martin, Alexander, Staffurth, John, Armstrong, John, Camilleri, Philip, Kancherla, Kiran, Frew, John, Chan, Andrew, Dayes, Ian S, Duffton, Aileen, Brand, Douglas H, Henderson, Daniel, Morrison, Kirsty, Brown, Stephanie, Pugh, Julia, Burnett, Stephanie, Mahmud, Muneeb, Hinder, Victoria, Naismith, Olivia, Hall, Emma, and van As, Nicholas

Published
2022
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6. Mucoepidermoid carcinoma of salivary glands: A French Network of Rare Head and Neck Tumors (REFCOR) prospective study of 292 cases

Author

Albert, S., Andry, G., Babin, E., Bach, C., Badet, J.-M., Badoual, C., Baglin, A.C., Banal, A., Barry, B., Baudin, E., Baujat, B., Bensadoun, R.J., Bertolus, C., Bessède, J.-P., Blanchard, D., Borel, C., Bozorg-Grayeli, A., Breheret, R., Breton, P., Brugel, L., Calais, G., Casiraghi, O., Cassagnau, E., Castillo, L., Ceruse, P., Chabolle, F., Chevalier, D., Chobaut, J.C., Choussy, O., Cosmidis, A., Coste, A., Costes, V., Crampette, L., Darrouzet, V., Demez, P., Dessi, P., Devauchelle, B., Dolivet, G., Dubrulle, F., Duflo, S., Dufour, X., Faivre, S., Fakhry, N., Ferron, C., Floret, F., de Gabory, L., Garrel, R., Geoffrois, L., Gilain, L., Giovanni, A., Girod, A., Guerrier, B., Hans, S., Herman, P., Hofman, P., Housset, M., Jankowski, R., Jegoux, F., Juliéron, M., Kaminsky, M.-C., Kolb, F., St Guily, J. Lacau, Laccoureye, L., Lallemant, B., Lang, P., Lartigau, E., Lavieille, J.-P., Lefevre, M., Leroy, X., Malard, O., Massip, F., Mauvais, O., Merol, J.-C., Michel, J., Mom, T., Morinière, S., de Monès, E., Moulin, G., Noel, G., Poissonnet, G., Prades, J.-M., Radulesco, T., de Raucourt, D., Reyt, E., Righini, C., Robin, Y. Marie, Rolland, F., Ruhin, B., Sarroul, N., Schultz, P., Serrano, E., Sterkers, O., Strunski, V., Sudaka, A., Tassart, M., Testelin, S., Thariat, J., Timochenko, A., Toussaint, B., Coste, E. Uro, Valette, G., Van den Abbeele, T., Varoquaux, A., Veillon, F., Vergez, S., Wassef, M., Dahan, Laurie Saloner, Giorgi, Roch, Vergez, Sébastien, Le Taillandier de Gabory, Ludovic, Costes-Martineau, Valérie, Herman, Philippe, Poissonnet, Gilles, Mauvais, Olivier, Malard, Olivier, Garrel, Renaud, Uro-Coste, Emmanuelle, Barry, Béatrix, Bach, Christine, Chevalier, Dominique, Mouawad, Francois, Merol, Jean-Claude, Bastit, Vianney, Thariat, Juliette, Gilain, Laurent, Dufour, Xavier, Righini, Christian-Adrien, Moya-Plana, Antoine, Even, Caroline, Radulesco, Thomas, Michel, Justin, Baujat, Bertrand, and Fakhry, Nicolas

Published
2021
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7. Delayed care for patients with newly diagnosed cancer due to COVID-19 and estimated impact on cancer mortality in France

Author

Blay, J.Y., Boucher, S., Le Vu, B., Cropet, C., Chabaud, S., Perol, D., Barranger, E., Campone, M., Conroy, T., Coutant, C., De Crevoisier, R., Debreuve-Theresette, A., Delord, J.P., Fumoleau, P., Gentil, J., Gomez, F., Guerin, O., Jaffré, A., Lartigau, E., Lemoine, C., Mahe, M.A., Mahon, F.X., Mathieu-Daude, H., Merrouche, Y., Penault-Llorca, F., Pivot, X., Soria, J.C., Thomas, G., Vera, P., Vermeulin, T., Viens, P., Ychou, M., and Beaupere, S.

Published
2021
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8. Chemotherapy and radiotherapy in locally advanced head and neck cancer: an individual patient data network meta-analysis

Author

Adelstein, D.J., Agarwal, J., Alfonsi, M., Argiris, A., Aupérin, A., Bacigalupo, A., Bar-Ad, V., Bartelink, H., Beadle, B., Belkacemi, Y., Bensadoun, R.J., Bernier, J., Blanchard, P., Bourhis, J., Bratland, Å., Brizel, D., Budach, V., Budach, W., Burtness, B., Calais, G., Campbell, B., Caudell, J., Chabaud, S., Chamorey, E., Chaukar, D., Cheugoua-Zanetsie, M., Cho, K.H., Choussy, O., Cruz Hernandez, J.J., Denham, J.W., Dobrowsky, W., Dominello, M.M, Driessen, C.M.L., Fallai, C., Forastiere, A.A., Fortpied, C., Fountzilas, G., Garaud, P., Garden, A.S., Gery, B., Ghadjar, P., Ghi, M.G., Ghosh Laskar, S., Graff-Cailleaud, P., Grau, C., Gregoire, V., Hackshaw, A., Haddad, E, Haffty, B.G., Hansen, A., Hay, J.H., Hayoz, S., Horiot, J.C., Hitt, R., Jeremic, B., Johansen, J., Jones, C., Julieron, M., Kristensen, C.A., Kumar, S., Lacas, B., Langendijk, J.A., Lapeyre, M., Lartigau, E., Licitra, L., Le, Q.T., Lee, J.W., Lee, P., Lewin, F., Li, Y., Lopes, A., Lotayef, M., Maciejewski, B., Mazeron, J.J., Mehta, S., Michalski, W., Moon, J., Moon, S.H., Moyal, E., Nankivell, M., Nilsson, P., Olmi, P., Orecchia, R., O'Sullivan, B., Overgaard, J., Parmar, M.K.B., Petit, C., Pignon, J.P., Pointreau, Y., Posner, M.R., Poulsen, M.G., Quon, H., Racadot, S., Rosenthal, D.I., Rovea, P., Ruo Redda, M.G., Sanguineti, G., Shenouda, G., Simes, J., Sharma, A., Simon, C., Sire, C., Skladowski, K., Spencer, S., Staar, S., Strojan, P., Stromberger, C., Suwinski, R., Szutkowski, Z., Takácsi-Nagy, Z., Tao, Y.G., Temam, S., Thomson, D., Tobias, J.S., Torres-Saavedra, P., Torri, V., Tripcony, L., Trotti, A., Tseroni, V., van Herpen, C., van Tinteren, H., Vermorken, J., Viegas, C.M.P., Vokes, E.E., Waldron, J., Wernecke, K.D, Widder, J., Wolf, G.T., Wong, S.J., Wu, J.S., Yamazaki, H., Zaktonik, B., Zackrisson, B., Zhong, L.P., Petit, Claire, Lacas, Benjamin, Pignon, Jean-Pierre, Le, Quynh Thu, Grégoire, Vincent, Grau, Cai, Hackshaw, Allan, Zackrisson, Björn, Parmar, Mahesh K B, Lee, Ju-Whei, Ghi, Maria Grazia, Sanguineti, Giuseppe, Temam, Stéphane, Cheugoua-Zanetsie, Maurice, O'Sullivan, Brian, Posner, Marshall R, Vokes, Everett E, Cruz Hernandez, Juan J, Szutkowski, Zbigniew, Lartigau, Eric, Budach, Volker, Suwiński, Rafal, Poulsen, Michael, Kumar, Shaleen, Ghosh Laskar, Sarbani, Mazeron, Jean-Jacques, Jeremic, Branislav, Simes, John, Zhong, Lai-Ping, Overgaard, Jens, Fortpied, Catherine, Torres-Saavedra, Pedro, Bourhis, Jean, Aupérin, Anne, and Blanchard, Pierre

Published
2021
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10. Intensity-modulated fractionated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): acute toxicity findings from an international, randomised, open-label, phase 3, non-inferiority trial

Author

Dodds, D, Lartigau, E, Patton, S, Thompson, A, Winkler, M, Wells, P, Lymberiou, T, Saunders, D, Vilarino-Varela, M, Vavassis, P, Tsakiridis, T, Carlson, R, Rodrigues, G, Tanguay, J, Iqbal, S, Morgan, S, Mihai, A, Li, A, Din, O, Panades, M, Wade, R, Rimmer, Y, Armstrong, J, Oommen, N, Brand, Douglas H, Tree, Alison C, Ostler, Peter, van der Voet, Hans, Loblaw, Andrew, Chu, William, Ford, Daniel, Tolan, Shaun, Jain, Suneil, Martin, Alexander, Staffurth, John, Camilleri, Philip, Kancherla, Kiran, Frew, John, Chan, Andrew, Dayes, Ian S, Henderson, Daniel, Brown, Stephanie, Cruickshank, Clare, Burnett, Stephanie, Duffton, Aileen, Griffin, Clare, Hinder, Victoria, Morrison, Kirsty, Naismith, Olivia, Hall, Emma, and van As, Nicholas

Published
2019
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16. Early Results of the French Multicenter, Randomized SHARE Trial Comparing Whole Breast Irradiation vs. Accelerated Partial Breast Irradiation in Postmenopausal Women with Early-Stage Breast Cancer

Author

Belkacemi, Y., primary, Gabelle-Flandin, I., additional, Deley, M. C. Le, additional, Petit, A., additional, Guilbert, P., additional, Geffrelot, J., additional, Carrie, C., additional, Rivin del Campo, E., additional, Hanzen, C., additional, Brunaud, C. Charra, additional, Lecouillard, I., additional, Magne, N., additional, Tallet, A. Richard, additional, Leduc, N., additional, Belgadi, B., additional, Auzac, G., additional, Lacornerie, T., additional, Lemonnier, J., additional, Bourgier, C., additional, and Lartigau, E., additional

Published
2023
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18. The role of ESTRO guidelines in achieving consistency and quality in clinical radiation oncology practice

Author

Vrou Offersen, B., Aznar, M. C., Bacchus, C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., (0000-0003-1776-9556) Krause, M., Lartigau, E. F., Lee, A. W. M., Löck, S., Thwaites, D. I., Kogel, A. J., Heide, U., Valentini, V., Overgaard, J., Baumann, M., Vrou Offersen, B., Aznar, M. C., Bacchus, C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., (0000-0003-1776-9556) Krause, M., Lartigau, E. F., Lee, A. W. M., Löck, S., Thwaites, D. I., Kogel, A. J., Heide, U., Valentini, V., Overgaard, J., and Baumann, M.

Abstract

Editorial In summary, ESTRO clinical and other guidelines are soundly based, but always require validation, careful and consistent implementation, and focused education and training on their use, as well as local monitoring of that. As guidelines develop and older ones become superseded, there should be a clear mechanism to inform the community of the status of specific guidelines, especially when they have been replaced by new or updated versions. An important scientific aim for the future is to further advance guidelines and their individual statements into fully evidence-based instruments. These, in principle, could be directly linked to growing data-bases, allowing feedback mechanisms and thus continuous optimization. Another challenging research topic is the interplay of guidelines with growing opportunities and demands of personalized approaches of treatment.

Published
2023

19. Are hybrid conferences the new standard?

Author

Baumann, M., Bacchus, C., Aznar, M. C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., (0000-0003-1776-9556) Krause, M., Lartigau, E. F., Lee, A. W. M., Löck, S., Offersen, B. V., Overgaard, J., Thwaites, D. I., Kogel, A. J., Heide, U. A., Valentini, V., Baumann, M., Bacchus, C., Aznar, M. C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., (0000-0003-1776-9556) Krause, M., Lartigau, E. F., Lee, A. W. M., Löck, S., Offersen, B. V., Overgaard, J., Thwaites, D. I., Kogel, A. J., Heide, U. A., and Valentini, V.

Abstract

This issue includes a perspective contribution by Lefresne et al. [1] on face-to-face scientific conferences versus virtual meetings and the implications for climate change. Generally, it is the policy of the Green Journal not to publish contributions with non-scientific content. In this specific case, the editors believe that the contribution by Lefresne and colleagues raises an important point that needs careful consideration and discussion in our scientific community. As scientists, we are at the forefront of research and strive to positively shape the future for humankind. Therefore, it is of key importance that the environmental impact of scientific activities is considered, and that our community develops and contributes to solutions to prevent further exacerbation of climate change with its substantial impact on health-related issues. This includes that pros and cons of face-to-face scientific meetings are carefully weighed.

Published
2023

25. Intensity-modulated radiotherapy versus stereotactic body radiotherapy for prostate cancer (PACE-B): 2-year toxicity results from an open-label, randomised, phase 3, non-inferiority trial

Author

Tree, Alison C, primary, Ostler, Peter, additional, van der Voet, Hans, additional, Chu, William, additional, Loblaw, Andrew, additional, Ford, Daniel, additional, Tolan, Shaun, additional, Jain, Suneil, additional, Martin, Alexander, additional, Staffurth, John, additional, Armstrong, John, additional, Camilleri, Philip, additional, Kancherla, Kiran, additional, Frew, John, additional, Chan, Andrew, additional, Dayes, Ian S, additional, Duffton, Aileen, additional, Brand, Douglas H, additional, Henderson, Daniel, additional, Morrison, Kirsty, additional, Brown, Stephanie, additional, Pugh, Julia, additional, Burnett, Stephanie, additional, Mahmud, Muneeb, additional, Hinder, Victoria, additional, Naismith, Olivia, additional, Hall, Emma, additional, van As, Nicholas, additional, Lartigau, E, additional, Patton, S, additional, Thompson, A, additional, Winkler, M, additional, Wells, P, additional, Lymberiou, T, additional, Saunders, D, additional, Vilarino-Varela, M, additional, Vavassis, P, additional, Tsakiridis, T, additional, Carlson, R, additional, Rodrigues, G, additional, Tanguay, J, additional, Iqbal, S, additional, Morgan, S, additional, Mihai, A, additional, Li, A, additional, Din, O, additional, Panades, M, additional, Wade, R, additional, Rimmer, Y, additional, and Oommen, N, additional

Published
2022
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27. LBA12 eMouvoir: Randomised phase III trial evaluating the impact of a personalized and remote physical activity (PA) for breast cancer survivors (BCS). Results on the quality of life (QoL)

Author

Vanlemmens, L., Lefeuvre-Plesse, C., Thery, J., Bogart, E., Aymes, E., Brochard, M-A., Le Gall, F., Belmimoun, M., Rotsaert, L., Mocaer, H., Prevost, J.B., Chocteau, D., Rhliouch, H., Lauridant Philippin, G., Mulliez, T., Najem, A., Hardy-Bessard, A-C., Lartigau, E., Anota, A., and Le Deley, M-C.

Published
2024
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34. Personalised radiation therapy taking both the tumour and patient into consideration

Author

Overgaard, J., Aznar, M. C., Bacchus, C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., (0000-0003-1776-9556) Krause, M., Lartigau, E. F., Lee, A. W. M., Steffen Löck J, B. V. O., Thwaites, D. I., Kogel, A. J., Heide, U. A., Valentini, V., Baumann, M., Overgaard, J., Aznar, M. C., Bacchus, C., Coppes, R. P., Deutsch, E., Georg, D., Haustermans, K., Hoskin, P., (0000-0003-1776-9556) Krause, M., Lartigau, E. F., Lee, A. W. M., Steffen Löck J, B. V. O., Thwaites, D. I., Kogel, A. J., Heide, U. A., Valentini, V., and Baumann, M.

Abstract

A look through almost 2000 abstracts submitted for the upcom- ing ESTRO 2022 meeting together with a glance back on the 2021 papers published in Radiotherapy and Oncology gives one a good impression of the (current) key focus areas in radiation oncology: Almost all of this work relates to optimal delivery of radiation ther- apy in terms of technology, quality assurance and morbidity reduc- ing approaches. Thus, at present the research questions considered as most relevant for radiotherapy of e.g. lung and oesophageal can- cer are not related to tumour control, but to the late risk of cardiac disease in the patients who are lucky to survive their cancer long enough to develop such problems [1]. The same scenario is found in the patient cohort that constitutes the largest indication for radiotherapy in Europe: women with early breast cancer [2]. In these examples, and in many other situations where radiotherapy is applied with a curative intent, less focus has currently been given to the aim or indication of the treatment, namely the control of loco-regional malignant disease. Of course, since Holthusen’s seminal paper in 1936 [3] the overall aim of radiotherapy, as stated over and over again by all teachers in the field (including the authors of this editorial), is uncomplicated tumour control, i.e. loco-regional tumour control without severe normal tissue damage (therapeutic ratio). This implies that rigorous study of the effects of radiotherapy on normal, non-tumour, tissues is an absolute necessity. Yet, the prescription of radiotherapy in clinical practice is done to kill tumour cells for local and loco-regional control. If the effects of radiotherapy on tumours are shifting out of focus, it might be taken for granted that the indication, dose, fractionation, and potential multidisciplinary interactions in this field are fully understood, and what remains is the fine tuning of the associated risk of morbidity.

Published
2022

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