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164 results on '"Lowis, Stephen"'

1. Clinical and genetic risk factors define two risk groups of extracranial malignant rhabdoid tumours (eMRT/RTK)

Author

Nemes, Karolina, Bens, Susanne, Kachanov, Denis, Teleshova, Margarita, Hauser, Peter, Simon, Thorsten, Tippelt, Stephan, Woessmann, Wilhelm, Beck, Olaf, Flotho, Christian, Grigull, Lorenz, Driever, Pablo H., Schlegel, Paul-Gerhardt, Khurana, Claudia, Hering, Kathrin, Kolb, Reinhard, Leipold, Alfred, Abbink, Floor, Gil-Da-Costa, Maria J., Benesch, Martin, Kerl, Kornelius, Lowis, Stephen, Marques, Carmen H., Graf, Norbert, Nysom, Karsten, Vokuhl, Christian, Melchior, Patrick, Kröncke, Thomas, Schneppenheim, Reinhard, Kordes, Uwe, Gerss, Joachim, Siebert, Reiner, Furtwängler, Rhoikos, and Frühwald, Michael C.

Published
2021
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2. PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults

Author

Fenwick, Nicola, primary, Weston, Rebekah, additional, Wheatley, Keith, additional, Hodgson, Jodie, additional, Marshall, Lynley, additional, Elliott, Martin, additional, Makin, Guy, additional, Ng, Antony, additional, Brennan, Bernadette, additional, Lowis, Stephen, additional, Adamski, Jenny, additional, Kilday, John Paul, additional, Cox, Rachel, additional, Gattens, Mike, additional, Moore, Andrew, additional, Trahair, Toby, additional, Ronghe, Milind, additional, Campbell, Martin, additional, Campbell, Helen, additional, Williams, Molly W., additional, Kirby, Maria, additional, Van Eijkelenburg, Natasha, additional, Keely, Jennifer, additional, Scarpa, Ugo, additional, Stavrou, Victoria, additional, Fultang, Livingstone, additional, Booth, Sarah, additional, Cheng, Paul, additional, De Santo, Carmela, additional, and Mussai, Francis, additional

Published
2024
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3. Pediatric Oncology

Author

Lowis, Stephen, primary, Cox, Rachel, additional, Moppett, John, additional, and Rees, Helen, additional

Published
2020
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4. Open-label, multicentre, randomised, phase II study of the EpSSG and the ITCC evaluating the addition of bevacizumab to chemotherapy in childhood and adolescent patients with metastatic soft tissue sarcoma (the BERNIE study)

Author

Chisholm, Julia C., Merks, Johannes H.M., Casanova, Michela, Bisogno, Gianni, Orbach, Daniel, Gentet, Jean-Claude, Thomassin-Defachelles, Anne-Sophie, Chastagner, Pascal, Lowis, Stephen, Ronghe, Milind, McHugh, Kieran, van Rijn, Rick R., Hilton, Magalie, Bachir, Jeanette, Fürst-Recktenwald, Sabine, Geoerger, Birgit, and Oberlin, Odile

Published
2017
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7. Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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8. Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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9. Supplementary Table S3 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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10. Embryonal and pineal tumours

Author

Taylor, Roger E., primary, Pizer, Barry L., additional, Tarbell, Nancy, additional, Brandes, Alba A., additional, and Lowis, Stephen, additional

Published
2017
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11. A nationwide evaluation of bevacizumab-based treatments in pediatric low-grade glioma in the UK: safety, efficacy, visual morbidity, and outcomes

Author

Green, Katherine, primary, Panagopoulou, Paraskevi, additional, D’Arco, Felice, additional, O’Hare, Patricia, additional, Bowman, Richard, additional, Walters, Bronwen, additional, Dahl, Christine, additional, Jorgensen, Mette, additional, Patel, Pritesh, additional, Slater, Olga, additional, Ahmed, Rehana, additional, Bailey, Simon, additional, Carceller, Fernando, additional, Collins, Rhiannon, additional, Corley, Elizabeth, additional, English, Martin, additional, Howells, Lisa, additional, Kamal, Ahmed, additional, Kilday, John-Paul (JP), additional, Lowis, Stephen, additional, Lumb, Blanche, additional, Pace, Erika, additional, Picton, Susan, additional, Pizer, Barry, additional, Shafiq, Ayad, additional, Uzunova, Lena, additional, Wayman, Harriet, additional, Wilson, Shaun, additional, Hargrave, Darren, additional, and Opocher, Enrico, additional

Published
2022
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12. LGG-09. A Nationwide Service Evaluation of Safety, Radiologic and Visual Outcome Refining Bevacizumab-based Treatments in Children with Progressive Low-Grade Glioma

Author

Green, Katherine, primary, Panagopoulou, Paraskevi, additional, D’Arco, Felice, additional, O'Hare, Patricia, additional, Bowman, Richard, additional, Walters, Bronwen, additional, Dahl, Christine, additional, Jorgensen, Mette, additional, Patel, Pritesh, additional, Slater, Olga, additional, Ahmed, Rehana, additional, Bailey, Simon, additional, Carceller, Fernando, additional, Collins, Rhiannon, additional, Corley, Elizabeth, additional, English, Martin, additional, Hayden, James, additional, Howells, Lisa, additional, Kamal, Ahmed, additional, Kilday, John Paul, additional, Lowis, Stephen, additional, Lumb, Blanche, additional, Micic, Thomas, additional, Mitra, Dip, additional, Pace, Erika, additional, Picton, Susan, additional, Pizer, Barry, additional, Shafiq, Ayad, additional, Uzunova, Lena, additional, Wilson, Shaun, additional, Wayman, Harriet, additional, Hargrave, Darren, additional, and Opocher, Enrico, additional

Published
2022
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13. QOL-34. The relationship between Psychological Flexibility, Quality-of-Life and psychological health in young people who have experienced a brain tumour

Author

Airdrie, Jac, primary, Geagan, Chloe, additional, Davies, Nicholas, additional, Powers, Katie, additional, Wright, Ingram, additional, Borrill, Heather, additional, Gibson, Faith, additional, Clifford, Steve, additional, Lowis, Stephen, additional, Bailey, Simon, additional, Limond, Jennifer, additional, Owen, Ray, additional, Grundy, Richard, additional, Lemon, James, additional, Hayes, Louise, additional, Malins, Sam, additional, and Thomas, Sophie, additional

Published
2022
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14. A nationwide evaluation of bevacizumab-based treatments in pediatric low-grade glioma in the UK: Safety, efficacy, visual morbidity, and outcomes.

Author

Green, Katherine, Panagopoulou, Paraskevi, D'Arco, Felice, O'Hare, Patricia, Bowman, Richard, Walters, Bronwen, Dahl, Christine, Jorgensen, Mette, Patel, Pritesh, Slater, Olga, Ahmed, Rehana, Bailey, Simon, Carceller, Fernando, Collins, Rhiannon, Corley, Elizabeth, English, Martin, Howells, Lisa, Kamal, Ahmed, Kilday, John-Paul (JP), and Lowis, Stephen

Published
2023
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17. The Impact of Radiation Therapy in Children and Adolescents With Metastatic Rhabdomyosarcoma

Author

Cameron, Alison L., primary, Elze, Markus C., additional, Casanova, Michela, additional, Geoerger, Birgit, additional, Gaze, Mark N., additional, Minard-Colin, Veronique, additional, McHugh, Kieran, additional, van Rijn, Rick R., additional, Kelsey, Anna, additional, Martelli, Hélène, additional, Mandeville, Henry, additional, Bisogno, Gianni, additional, Lowis, Stephen, additional, Ronghe, Milind, additional, Orbach, Daniel, additional, Guizani, Cecile, additional, Fürst-Recktenwald, Sabine, additional, Chisholm, Julia C., additional, and Merks, Johannes H.M., additional

Published
2021
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20. ENDGAMES

Author

Sedgwick, Philip, Jones, Benjamin R T, Renowden, Shelley A, Lowis, Stephen P, and Kurian, Kathreena M

Published
2013

23. Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue

Author

Heravi Shargh, Vahid, primary, Luckett, Jeni, additional, Bouzinab, Kaouthar, additional, Paisey, Stephen, additional, Turyanska, Lyudmila, additional, Singleton, William G. B., additional, Lowis, Stephen, additional, Gershkovich, Pavel, additional, Bradshaw, Tracey D., additional, Stevens, Malcolm F. G., additional, Bienemann, Alison, additional, and Coyle, Beth, additional

Published
2021
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24. Acceptance and commitment therapy for young brain tumour survivors: study protocol for an acceptability and feasibility trial

Author

Malins, Sam, primary, Owen, Ray, additional, Wright, Ingram, additional, Borrill, Heather, additional, Limond, Jenny, additional, Gibson, Faith, additional, Grundy, Richard G, additional, Bailey, Simon, additional, Clifford, Steven C, additional, Lowis, Stephen, additional, Lemon, James, additional, Hayes, Louise, additional, and Thomas, Sophie, additional

Published
2021
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26. GCT-61. CORRELATION OF PATTERNS OF DISEASE RECURRENCE WITH RADIOTHERAPY TECHNIQUES AND DOSE IN INTRACRANIAL GERM CELL TUMOURS (icGCT): LESSONS FROM THE UK COHORT OF SIOP GCT96 STUDY

Author

Ajithkumar, Thankamma, primary, Mandeville, Henry, additional, Carceller, Fernando, additional, Ronghe, Milind, additional, Foord, Tina, additional, Lowis, Stephen, additional, Kwok-Williams, Michelle, additional, Calaminus, Gabriele, additional, Murray, Matthew, additional, and Nicholson, James, additional

Published
2020
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27. Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, additional, Ismer, Britta, additional, Pickles, Jessica C., additional, Tatevossian, Ruth G., additional, Newman, Scott, additional, Bale, Tejus A., additional, Stoler, Iris, additional, Izquierdo, Elisa, additional, Temelso, Sara, additional, Carvalho, Diana M., additional, Molinari, Valeria, additional, Burford, Anna, additional, Howell, Louise, additional, Virasami, Alex, additional, Fairchild, Amy R., additional, Avery, Aimee, additional, Chalker, Jane, additional, Kristiansen, Mark, additional, Haupfear, Kelly, additional, Dalton, James D., additional, Orisme, Wilda, additional, Wen, Ji, additional, Hubank, Michael, additional, Kurian, Kathreena M., additional, Rowe, Catherine, additional, Maybury, Mellissa, additional, Crosier, Stephen, additional, Knipstein, Jeffrey, additional, Schüller, Ulrich, additional, Kordes, Uwe, additional, Kram, David E., additional, Snuderl, Matija, additional, Bridges, Leslie, additional, Martin, Andrew J., additional, Doey, Lawrence J., additional, Al-Sarraj, Safa, additional, Chandler, Christopher, additional, Zebian, Bassel, additional, Cairns, Claire, additional, Natrajan, Rachael, additional, Boult, Jessica K.R., additional, Robinson, Simon P., additional, Sill, Martin, additional, Dunkel, Ira J., additional, Gilheeney, Stephen W., additional, Rosenblum, Marc K., additional, Hughes, Debbie, additional, Proszek, Paula Z., additional, Macdonald, Tobey J., additional, Preusser, Matthias, additional, Haberler, Christine, additional, Slavc, Irene, additional, Packer, Roger, additional, Ng, Ho-Keung, additional, Caspi, Shani, additional, Popović, Mara, additional, Faganel Kotnik, Barbara, additional, Wood, Matthew D., additional, Baird, Lissa, additional, Davare, Monika Ashok, additional, Solomon, David A., additional, Olsen, Thale Kristin, additional, Brandal, Petter, additional, Farrell, Michael, additional, Cryan, Jane B., additional, Capra, Michael, additional, Karremann, Michael, additional, Schittenhelm, Jens, additional, Schuhmann, Martin U., additional, Ebinger, Martin, additional, Dinjens, Winand N.M., additional, Kerl, Kornelius, additional, Hettmer, Simone, additional, Pietsch, Torsten, additional, Andreiuolo, Felipe, additional, Driever, Pablo Hernáiz, additional, Korshunov, Andrey, additional, Hiddingh, Lotte, additional, Worst, Barbara C., additional, Sturm, Dominik, additional, Zuckermann, Marc, additional, Witt, Olaf, additional, Bloom, Tabitha, additional, Mitchell, Clare, additional, Miele, Evelina, additional, Colafati, Giovanna Stefania, additional, Diomedi-Camassei, Francesca, additional, Bailey, Simon, additional, Moore, Andrew S., additional, Hassall, Timothy E.G., additional, Lowis, Stephen P., additional, Tsoli, Maria, additional, Cowley, Mark J., additional, Ziegler, David S., additional, Karajannis, Matthias A., additional, Aquilina, Kristian, additional, Hargrave, Darren R., additional, Carceller, Fernando, additional, Marshall, Lynley V., additional, von Deimling, Andreas, additional, Kramm, Christof M., additional, Pfister, Stefan M., additional, Sahm, Felix, additional, Baker, Suzanne J., additional, Mastronuzzi, Angela, additional, Carai, Andrea, additional, Vinci, Maria, additional, Capper, David, additional, Popov, Sergey, additional, Ellison, David W., additional, Jacques, Thomas S., additional, Jones, David T.W., additional, and Jones, Chris, additional

Published
2020
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28. Management of severe pulmonary Langerhans cell histiocytosis in children

Author

Eckstein, Olive S., primary, Nuchtern, Jed G., additional, Mallory, George B., additional, Guillerman, R. Paul, additional, Musick, Matthew A., additional, Barclay, Mhairi, additional, Bhatt, Jayesh M., additional, Davies, Patrick, additional, Grundy, Richard G., additional, Martin, Alice, additional, Hilliard, Tom, additional, Lowis, Stephen P., additional, Picton, Susan, additional, Nanduri, Vasanta, additional, Visser, Johannes, additional, Allen, Carl E., additional, and McClain, Kenneth L., additional

Published
2020
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40. Children's brain tumour drug delivery consortium

Author

Rahman, Ruman, Grundy, Richard, Campbell, Emma, Brem, Henry, Pearl, Monica, Green, Jordan, Janoski, Miroslav, Cohen, Kenneth, Walczak, Piotr, Warren, Katherine, Lowis, Stephen, Alexander Mullen, Boyd, Marie, Veal, Gareth, Hargrave, Darren, Vuurden, Dannis, Powell, Stephen, and Walker, David

Subjects
RS
Abstract

INTRODUCTION: Whilst there is an urgent need to expedite the development of new or repurposed drugs for children’s cancer, the additional challenge in the developing brain is to ensure the drug is delivered to the tumour at therapeutic and non toxic concentrations for sufficient duration to achieve the biological effect. This is the necessary focus for personalised medicine agendas in children’s brain tumours as they account for over 20% of childhood cancer and differ significantly in their biological characteristics from their adult counterparts. METHODS: The authors took part in an international CNS drug delivery London workshop funded by the charity Children with Cancer UK (CwC) in February 2016 where different experimental techniques aimed at optimising CNS drug delivery in children’s brain tumours were presented and discussed. RESULTS: The workshop was reported (1) and promoted through e-cancer (2). We were encouraged to develop a proposal, to establish an international research consortium to raise awareness and promote collaboration in the field. This is now to be funded for two years by Children with Cancer. The Children’s Brain Tumour Drug Delivery Consortium will organise and host discussions between an international, multi-disciplinary network of clinicians and researchers within pharma and academia as well as a range of funders and stakeholders. This Consortium seeks to strengthen collaborative developments by working closely with the international children’s brain tumour community. CONCLUSION: We present this abstract to the SNO Pediatric conference to launch this initiative in North America and invite collaborators to promote this research priority for children across the world and to consider joining the consortium, which will be presented at the conference.

Published
2017

41. Delphi method to identify expert opinion to support children's cancer referral guidelines.

Author

Murray, Matthew J., Ruffle, Amy, Lowis, Stephen, Howell, Lisa, Shanmugavadivel, Dhurgshaarna, Dommett, Rachel, Gamble, Ashley, Shenton, Geoff, and Nicholson, James

Subjects
DELPHI method, ONCOLOGISTS, CHILDHOOD cancer, HEMATOLOGISTS, MEDICAL personnel, NATIONAL health services, TERTIARY care
Abstract

Background: The National Institute for Health and Care Excellence (NICE) guidance for referral of children with suspected cancer was first published in 2005 and updated in 2015. The updated version relied on sparse primary care evidence and published without input from key stakeholders, for example, acute general paediatricians and paediatric haematologists/oncologists. This led to a document that fell short as a practical guide for referring physicians managing children with potentially life-threatening conditions. Following discussions between the Children's Cancer and Leukaemia Group (CCLG, the UK multidisciplinary professional body for healthcare professionals caring for children with cancer) and NICE, it was agreed that a practical supplement should be produced for the 2015 guidance. A prerequisite was evidence gathering from tertiary care to balance the existing primary care evidence, and a Delphi consensus method was therefore convened.Methods: A CCLG NICE Guidance Committee formulated 25 draft statements for review. The CCLG emailed its paediatric haematologist/oncologist membership (n=179) and 88 responded (49%). To achieve consensus, statements required ≥70% agreement from ≥60% of actual respondents, from the denominator (n=88).Results: Fifteen of 25 original statements were accepted at the first round of voting. Three of 25 statements where >50% did not support were rejected outright. One statement could not be revised without replicating a previously accepted statement. The six remaining statements were revised and a second round of voting undertaken; all six revised statements were accepted. Overall, 21 of 25 statements (84%) met consensus criteria.Conclusions: This expert opinion should help streamline suspected cancer referral in children and help optimise subsequent outcomes. [ABSTRACT FROM AUTHOR]

Published
2020
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42. ATRT-23. SMARCB1-DEPENDENCIES IN ATYPICAL TERATOID/RHABDOID TUMOURS: A STRATEGY FOR PRE-CLINICAL THERAPEUTIC TARGET IDENTIFICATION IN THE ABSENCE OF ACTIONABLE MUTATIONS

Author

Finetti, Martina Anna, primary, Selby, Matthew p, additional, Pons, Alicia del-Carpio, additional, Batting, Sarah, additional, Wood, James A, additional, Barker, James M, additional, Smith, Amanda, additional, Crosier, Stephen, additional, Bashton, Matthew, additional, Pickles, Jessica C, additional, Fairchild, Amy R, additional, Avery, Aimee, additional, O’Hare, Patricia, additional, Pizer, Barry, additional, Brennan, Bernadette, additional, Lowis, Stephen, additional, Hargrave, Darren, additional, Jacques, Thomas S, additional, Bailey, Simon, additional, Clifford, Steven C, additional, and Williamson, Daniel, additional

Published
2018
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43. EAPH-07. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM

Author

Rahman, Ruman, primary, Grundy, Richard, additional, Campbell, Emma, additional, Brem, Henry, additional, Pearl, Monica, additional, Green, Jordan, additional, Janowski, Miroslav, additional, Cohen, Kenneth, additional, Walczak, Piotr, additional, Warren, Katherine, additional, Lowis, Stephen, additional, Mullen, Alexander, additional, Boyd, Marie, additional, Veal, Gareth, additional, Hargrave, Darren, additional, van Vuurden, Dannis, additional, Powell, Steven, additional, and Walker, David, additional

Published
2018
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44. HGG-25. INFANT GLIOMAS COMPRISE MULTIPLE BIOLOGICAL AND CLINICOPATHOLOGICAL SUBGROUPS

Author

Clarke, Matthew T, primary, Jones, David TW, additional, Mackay, Alan, additional, Carvalho, Diana, additional, Izquierdo, Elisa, additional, Hiddingh, Lotte, additional, Temelso, Sara, additional, Burford, Anna, additional, Molinari, Valeria, additional, Boult, Jessica KR, additional, Virasami, Alex, additional, Carceller, Fernando, additional, Marshall, Lynley V, additional, Zebian, Bassel, additional, Chandler, Chris, additional, Al-Sarraj, Safa, additional, Lowis, Stephen, additional, Knipstein, Jeffrey, additional, Bailey, Simon, additional, Crosier, Stephen, additional, Mastronuzzi, Angela, additional, Carai, Andrea, additional, Ellison, David W, additional, Baker, Suzanne J, additional, Capper, David, additional, Maybury, Mellissa, additional, Moore, Andrew S, additional, Vinci, Maria, additional, Hargrave, Darren, additional, Popov, Sergey, additional, Jacques, Thomas S, additional, and Jones, Chris, additional

Published
2018
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45. PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer

Author

Bate, Jessica, primary, Baker, Stephen, additional, Breuer, Judith, additional, Chisholm, Julia C, additional, Gray, Juliet, additional, Hambleton, Sophie, additional, Houlton, Aimee, additional, Jit, Mark, additional, Lowis, Stephen, additional, Makin, Guy, additional, O’Sullivan, Catherine, additional, Patel, Soonie R, additional, Phillips, Robert, additional, Ransinghe, Neil, additional, Ramsay, Mary Elizabeth, additional, Skinner, Roderick, additional, Wheatley, Keith, additional, and Heath, Paul T, additional

Published
2018
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46. Highlights of children with Cancer UK’s workshop on drug delivery in paediatric brain tumours

Author

Nailor, Audrey, Walker, David A., Jacques, Thomas S., Warren, Kathy E., Brem, Henry, Kearns, Pamela R., Greenwood, John, Penny, Jeffrey I., Pilkington, Geoffrey J., Carcaboso, Angel M., Fleischhack, Gudrun, Macarthur, Donald, Slavc, Irene, Meijer, Lisethe, Gill, Steven, Lowis, Stephen, van Vuurden, Dannis G., Pearl, Monica S., Clifford, Steven C., Morrissy, A. Sorana, Ivanov, Delyan P., Gilbertson, Richard J., Straathof, Karin, Green, Jordan J., Smith, Stuart, Rahman, Ruman, and Kilday, John-Paul

Subjects
Drug delivery, translational medicine, paediatrics, brain tumours, glioma, medulloblastoma, CNS involvement, blood-brain barrier
Abstract

The first Workshop on Drug Delivery in Paediatric Brain Tumours was hosted in London by the charity Children with Cancer UK. The goals of the workshop were to break down the barriers to treating central nervous system (CNS) tumours in children, leading to new collaborations and further innovations in this under-represented and emotive field. These barriers include the physical delivery challenges presented by the blood–brain barrier, the underpinning reasons for the intractability of CNS cancers, and the practical difficulties of delivering cancer treatment to the brains of children. Novel techniques for overcoming these problems were discussed, new models brought forth, and experiences compared.

Published
2016

47. SCDT-27. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM

Author

Rahman, Ruman, primary, Grundy, Richard, additional, Campbell, Emma, additional, Brem, Henry, additional, Pearl, Monica, additional, Green, Jordan, additional, Janowski, Miroslaw, additional, Cohen, Kenneth, additional, Walczak, Piotr, additional, Warren, Katherine, additional, Lowis, Stephen, additional, Mullen, Alexander, additional, Boyd, Marie, additional, Veal, Gareth, additional, Hargrave, Darren, additional, van Vuurden, Dannis, additional, Powell, Stephen, additional, and Walker, David, additional

Published
2017
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48. TRTH-06. CHILDREN’S BRAIN TUMOUR DRUG DELIVERY CONSORTIUM

Author

Rahman, Ruman, primary, Grundy, Richard, additional, Campbell, Emma, additional, Brem, Henry, additional, Pearl, Monica, additional, Green, Jordan, additional, Janowski, Miroslav, additional, Cohen, Kenneth, additional, Walczak, Piotr, additional, Warren, Katherine, additional, Lowis, Stephen, additional, Mullen, Alexander, additional, Boyd, Marie, additional, Veal, Gareth, additional, Hargrave, Darren, additional, van Vuurden, Dannis, additional, Powell, Stephen, additional, and Walker, David, additional

Published
2017
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50. The Nopho-European Study on Cerebellar Mutism Syndrome (CMS)

Author

Wibroe, Morten, Avula, Shivaram, Cappelen, Johan, Castor, Charlotte, Clausen, Niels, Devenney, Irene, Fellows, Greg, Grillner, Pernilla, Gupta, Ramneek, Gustavsson, Bengt, Heyman, Mats, Holm, Stefan, Karppinen, Atte, Kiudeliene, Rosita, Klausen, Camilla, Lahteenmaki, Paivi, Lönnqvist, Tuula, Lowis, Stephen, Mallucci, Conor, Mathiasen, Rene, Mattson, Mattias, Nilsson, Pelle, Nordfors, Kristiina, Nyman, Per, Nysom, Karsten, Persson, Karin, Pesola, Jouni, Pizer, Barry, Rask, Olof, Sabel, Magnus, Schmiegelow, Kjeld, Sehested, Astrid, Tonning-Olsson, Ingrid, Torsvik, Ingrid Kristin, van Baarsen, Kirsten, Walker, David, Westerholm-Ormio, Mia, Zetterqvist, Barbara, Juhler, Marianne, Wibroe, Morten, Avula, Shivaram, Cappelen, Johan, Castor, Charlotte, Clausen, Niels, Devenney, Irene, Fellows, Greg, Grillner, Pernilla, Gupta, Ramneek, Gustavsson, Bengt, Heyman, Mats, Holm, Stefan, Karppinen, Atte, Kiudeliene, Rosita, Klausen, Camilla, Lahteenmaki, Paivi, Lönnqvist, Tuula, Lowis, Stephen, Mallucci, Conor, Mathiasen, Rene, Mattson, Mattias, Nilsson, Pelle, Nordfors, Kristiina, Nyman, Per, Nysom, Karsten, Persson, Karin, Pesola, Jouni, Pizer, Barry, Rask, Olof, Sabel, Magnus, Schmiegelow, Kjeld, Sehested, Astrid, Tonning-Olsson, Ingrid, Torsvik, Ingrid Kristin, van Baarsen, Kirsten, Walker, David, Westerholm-Ormio, Mia, Zetterqvist, Barbara, and Juhler, Marianne

Published
2016

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