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Your search keyword '"Luo, Jianchen"' showing total 13 results
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13 results on '"Luo, Jianchen"'

1. A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27

Author

Xu, Liangliang, primary, Zhang, Jinfu, additional, Li, Li, additional, Wang, Peng, additional, Zheng, Xiaobo, additional, Luo, Jianchen, additional, Zhang, Shuqi, additional, Li, Lian, additional, Yi, Pengsheng, additional, Zhang, Yanfang, additional, Yan, Tao, additional, Xie, Liang, additional, Feng, Lei, additional, Zhang, Ming, additional, and Xu, Mingqing, additional

Published
2023
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8. Robust Vehicle Speed Measurement Based on Feature Information Fusion for Vehicle Multi-Characteristic Detection

Author

Li Menglong, Lei Yang, Xiaowei Song, Zixiang Xiong, Pengwei Wen, and Luo Jianchen

Subjects
cross-channel interaction, Computer science, Science, QC1-999, General Physics and Astronomy, Word error rate, 02 engineering and technology, vehicle speed measurement, Residual, Astrophysics, Article, YOLOv4, Robustness (computer science), 0502 economics and business, 0202 electrical engineering, electronic engineering, information engineering, Computer vision, feature information fusion, ECA, 050210 logistics & transportation, business.industry, Physics, 05 social sciences, FLOPS, Object detection, QB460-466, Information fusion, Feature (computer vision), 020201 artificial intelligence & image processing, Artificial intelligence, business, Communication channel
Abstract

A robust vehicle speed measurement system based on feature information fusion for vehicle multi-characteristic detection is proposed in this paper. A vehicle multi-characteristic dataset is constructed. With this dataset, seven CNN-based modern object detection algorithms are trained for vehicle multi-characteristic detection. The FPN-based YOLOv4 is selected as the best vehicle multi-characteristic detection algorithm, which applies feature information fusion of different scales with both rich high-level semantic information and detailed low-level location information. The YOLOv4 algorithm is improved by combing with the attention mechanism, in which the residual module in YOLOv4 is replaced by the ECA channel attention module with cross channel interaction. An improved ECA-YOLOv4 object detection algorithm based on both feature information fusion and cross channel interaction is proposed, which improves the performance of YOLOv4 for vehicle multi-characteristic detection and reduces the model parameter size and FLOPs as well. A multi-characteristic fused speed measurement system based on license plate, logo, and light is designed accordingly. The system performance is verified by experiments. The experimental results show that the speed measurement error rate of the proposed system meets the requirement of the China national standard GB/T 21555-2007 in which the speed measurement error rate should be less than 6%. The proposed system can efficiently enhance the vehicle speed measurement accuracy and effectively improve the vehicle speed measurement robustness.

Published
2021

13. A human commensal-pathogenic fungus suppresses host immunity via targeting TBK1.

Author

Luo G, Zhang J, Wang T, Cui H, Bai Y, Luo J, Zhang J, Zhang M, Di L, Yuan Y, Xiong K, Yu X, Zhang Y, Shen C, Zhu C, Wang Y, Su C, and Lu Y

Abstract

Candida albicans stably colonizes humans but is the leading cause of hospital-acquired fungemia. Traditionally, masking immunogenic moieties has been viewed as a tactic for immune evasion. Here, we demonstrate that C. albicans blocks type I interferon (IFN-I) signaling via translocating an effector protein Cmi1 into host cells. Mechanistically, Cmi1 binds and inhibits TANK-binding kinase 1 (TBK1) to abrogate IFN-regulatory factor 3 (IRF3) phosphorylation, thereby suppressing the IFN-I cascade. Murine infection with a cmi1 mutant displays an exaggerated IFN-I response in both kidneys and bone-marrow-derived macrophages, leading to rapid fungal clearance and host survival. Remarkably, the lack of CMI1 compromises gut commensalism and increases IFN-I response in mouse colonic cells. These phenotypes of cmi1 are rescued by the depletion of IFN-I receptor. This work establishes the importance of TBK1 inhibition in fungal pathogenesis and reveals that a human commensal-pathogenic fungus significantly impacts host immunity during gut colonization and infection via delivering effector proteins into host cells., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 Elsevier Inc. All rights reserved.)

Published
2024
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