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Photodynamic therapy (PDT) is a spatiotemporally controllable, powerful approach in combating cancers but suffers from low activity under hypoxia, whereas photoactivated chemotherapy (PACT) operates in an O2‐independent manner but compromises the ability to harness O2 for potent photosensitization. Herein we report that cyclometalated gold(III)‐alkyne complexes display a PDT‐to‐PACT evolving photoactivity for efficient cancer treatment. On the one hand, the gold(III) complexes can act as dual photosensitizers and substrates, leading to conditional PDT activity in oxygenated condition that progresses to highly efficient PACT (ϕ up to 0.63) when O2 is depleted in solution and under cellular environment. On the other hand, the conditional PDT‐to‐PACT reactivity can be triggered by external photosensitizers in a similar manner in vitro and in vivo, giving additional tumor‐selectivity and/or deep tissue penetration by red‐light irradiation that leads to robust anticancer efficacy. [ABSTRACT FROM AUTHOR]

To better understand the long-term changes of the East Asian summer monsoon precipitation (Pjja), quantitative reconstructions and model simulations are needed. Here, we develop continental-scale pollen-based transfer functions for Pjja with weighted averaging–partial least squares (WA-PLS) regression and a Bayesian multinomial regression method. We apply these transfer functions to a set of fossil pollen data from monsoonal China for quantitatively reconstructing the Pjja changes over the last 9500 years. We compare the reconstructions with Pjja simulations from a coupled atmosphere–ocean–sea ice general circulation model (the Kiel Climate Model, KCM). The results of cross-validation tests for the transfer functions show that both the WA-PLS model (r2 = 0.83, root mean square error of prediction (RMSEP) = 112.11 mm) and the Bayesian model (r2 = 0.86, RMSEP = 107.67 mm) exhibit good predictive performance. We stack all Pjja reconstructions from northern China to a summary curve. The stacked record reveals that Pjja increased since 9500 cal. yr BP, attained its highest level during the Holocene summer monsoon maximum (HSMM) at ~7000–4000 cal. yr BP and declined to present. The KCM output and the reconstructions differ in the early-Holocene (~9500–7000 cal. yr BP) where the model suggests higher Pjja than the reconstructions. Moreover, during the HSMM, the amplitude of the Pjja changes (~20–60 mm above present) in simulations is lower than the reconstructed changes (~70–110 mm above present). The rising (declining) Pjja patterns in reconstructions before (after) the HSMM are more pronounced and fluctuating than in simulations. Other palaeohydrological data such as lake-level reconstructions indicate substantial monsoon precipitation changes throughout the Holocene. Our results therefore show that the KCM underestimates the overall amplitude of the Holocene monsoon precipitation changes. [ABSTRACT FROM AUTHOR]

Photodynamic therapy (PDT) is a spatiotemporally controllable, powerful approach in combating cancers but suffers from low activity under hypoxia, whereas photoactivated chemotherapy (PACT) operates in an O 2 -independent manner but compromises the ability to harness O 2 for potent photosensitization. Herein we report that cyclometalated gold(III)-alkyne complexes display a PDT-to-PACT evolving photoactivity for efficient cancer treatment. On the one hand, the gold(III) complexes can act as dual photosensitizers and substrates, leading to conditional PDT activity in oxygenated condition that progresses to highly efficient PACT (ϕ up to 0.63) when O 2 is depleted in solution and under cellular environment. On the other hand, the conditional PDT-to-PACT reactivity can be triggered by external photosensitizers in a similar manner in vitro and in vivo, giving additional tumor-selectivity and/or deep tissue penetration by red-light irradiation that leads to robust anticancer efficacy., (© 2022 Wiley-VCH GmbH.)

A facile and new anion exchange process is presented, which involves the conversion of NiCo-CO 3 layered double hydroxide (LDH) nanosheet arrays in an alkaline solution. The anion exchange between CO 3 2- and OH - results in the construction of a reservoir for OH - anions, and the decoration of thin nanoflakes on the surface of nanosheets effectively enlarges the surface area of NiCo LDH nanoarrays. The capacitance of the as-soaked NiCo LDH nanoarrays electrode increases from 1.78 F cm -2 (684 F g -1 ) to 6.22 F cm -2 (2391 F g -1 ) at 2 mA cm -2 after soaking for 12 h. Moreover, the soaked NiCo-OH LDH electrode exhibits an enhanced rate capacity, high coulombic efficiency, and good cycling stability compared with the Ni-Co-S nanosheet electrode synthesized through a hydrothermal sulfuration process. The as-assembled all-solid-state NiCo LDH//active carbon asymmetric supercapacitor shows a maximum energy density of 83.4 W h kg -1 at a power density of 1066 W kg -1 ., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)