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Nguyen Van An,1,* Le Huy Hoang,2,* Hai Ha Long Le,3,4 Nguyen Thai Son,1 Le Thu Hong,1 Tien Tran Viet,5 Tuan Dinh Le,6 Ta Ba Thang,7 Luong Huy Vu,8,9 Vinh Thi Ha Nguyen,9,10 Kien Xuan Nguyen11 1Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 2Department of Bacteriology, National of Hygiene and Epidemiology, Hanoi, Vietnam; 3Department of Microbiology, Mycology and Parasitology, National hospital of Dermatology and Venereology, Hanoi, Vietnam; 4Department of Clinical Microbiology and Parasitology, Ha Noi Medical University, Hanoi, Vietnam; 5Department of Infectious Diseases, Military Hospital 103, Vietnam Medical Military University, Hanoi, Vietnam; 6Department of Rheumatology and Endocrinology, Military Hospital 103, Vietnam Medical Military University, Hanoi, Vietnam; 7Respiratory Center, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam; 8Department of Laser and Skin Care, National hospital of Dermatology and Venereology, Hanoi, Vietnam; 9Department of Dermatology and Venereology, Ha Noi Medical University, Hanoi, Vietnam; 10Department of General Planning, National hospital of Dermatology and Venereology, Hanoi, Vietnam; 11Department of Military Medical Command and Organization, Vietnam Medical Military University, Hanoi, Vietnam*These authors contributed equally to this workCorrespondence: Kien Xuan Nguyen, Department of Military Medical Command and Organization, Vietnam Medical Military University, Hanoi, Vietnam, Email nguyenxuankien@vmmu.edu.vnPurpose: Studies on the epidemiology of bloodstream infection (BSI) and antimicrobial resistance (AMR) are limited in Vietnam. Thus, the present study aimed to elucidate the epidemiology of BSI and AMR of BSI-causing bacteria in Vietnam.Methods: Data regarding blood cultures from 2014 to 2021 were collected and analyzed using the chi-square test, Cochran–Armitage test, and binomial logistic regression model.Results: Overall, 2405 (14.15%) blood cultures were positive during the study period. In total, 55.76% of BSIs occurred in patients aged ≥ 60 years. The male-to-female ratio of patients with BSI was 1.87:1. Escherichia coli (26.11%), Staphylococcus aureus (15.79%), Klebsiella pneumoniae (10.44%), Acinetobacter baumannii (4.70%), and Pseudomonas aeruginosa (3.45%) were the leading bacterial species causing BSI. The AMR rate of these bacteria isolated in the intensive care unit (ICU) was significantly higher compared with that of those in other wards. E. coli was the least resistant to carbapenems (2.39%– 4.14%), amikacin (3.85%), and colistin (11.54%) and most resistant to penicillins (> 80.0%). S. aureus was the least resistant to glycopeptides (0%– 3.38%), quinupristin-dalfopristin (0.59%), and linezolid (1.02%) and most resistant to clindamycin (71.57%). K. pneumoniae was the least resistant to ertapenem (8.86%), amikacin (9.39%), and colistin (15.38%) and most resistant to aztreonam (83.33%). A. baumannii was the least resistant to amikacin (16.67%) and colistin (16.67%) and highly resistant to other antibiotics (≥ 50.0%). P. aeruginosa was the least resistant to colistin (16.33%) and piperacillin (28.17%) and highly resistant to other antibiotics (≥ 50.0%). Notably, the multidrug resistance rate of E. coli (76.41%) was the highest among common pathogens, followed by A. baumannii (71.57%), P. aeruginosa (64.56%), S. aureus (56.99%), and K. pneumoniae (43.72%).Conclusion: The AMR rate of BSI-causing bacteria, particularly strains isolated from ICU, was alarmingly high. There is a need for new antibiotics, therapeutic strategies, as well as prevention and control to combat BSI and AMR.Keywords: bloodstream infection, antimicrobial resistance, multidrug resistance, methicillin-resistantStaphylococcus aureus

Quarteny Loyalty is an interactive story where you play as a person from Quarteny, the only city on the world of endless sand, taking a job from the city's most honorable department: The Special Force. From there, you start to discover secrets that The Special Force, as well as the leaders of Quarteny, has been hiding for hundreds of years. This game aims to deliver the sense of mystery and secrecy through story telling. By making choices within the game, the player will be able to discover different endings, making replaying the game important if the player wishes to discover all secrets in the story.