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348 results on '"Mäkisalo, Heikki"'

1. NGS of brush cytology samples improves the detection of high-grade dysplasia and cholangiocarcinoma in patients with primary sclerosing cholangitis: A retrospective and prospective study

Author

Boyd, Sonja, primary, Mustamäki, Taru, additional, Sjöblom, Nelli, additional, Nordin, Arno, additional, Tenca, Andrea, additional, Jokelainen, Kalle, additional, Rantapero, Tommi, additional, Liuksiala, Thomas, additional, Lahtinen, Laura, additional, Kuopio, Teijo, additional, Kytölä, Soili, additional, Mäkisalo, Heikki, additional, Färkkilä, Martti, additional, and Arola, Johanna, additional

Published
2024
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3. Treatment response of colorectal cancer liver metastases to neoadjuvant or conversion therapy: a prospective multicentre follow-up study using MRI, diffusion-weighted imaging and 1H-MR spectroscopy compared with histology (subgroup in the RAXO trial)

Author

Mäkisalo, Heikki, Huuhtanen, Riikka, Kosunen, Juhani, Leppä, Sirpa, Bono, Petri, Mattson, Johanna, Österlund, Emerik, Penttinen, Heidi, Mäkelä, Siru, Carpén, Olli, Timonen, Marjut, Lehtomäki, Kaisa, Salminen, Veera, Paunu, Niina, Vornanen, Martine, Lasse, Nieminen, Heervä, Eetu, Korkeila, Eija, Sutinen, Eija, Lavonius, Maija, Sundström, Jari, Mäkinen, Markus, Poussa, Tuija, Uutela, A., Ovissi, A., Hakkarainen, A., Ristimäki, A., Lundbom, N., Kallio, R., Soveri, L.M., Salminen, T., Ålgars, A., Halonen, P., Ristamäki, R., Nordin, A., Blanco Sequeiros, R., Rinta-Kiikka, I., Lantto, E., Virtanen, J., Pääkkö, E., Liukkonen, E., Saunavaara, J., Ryymin, P., Lammentausta, E., Osterlund, P., and Isoniemi, H.

Published
2021
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6. High immune cell infiltration predicts improved survival in cholangiocarcinoma.

Author

Wirta, Erkki-Ville, Szeto, Säde, Koppatz, Hanna, Nordin, Arno, Mäkisalo, Heikki, Arola, Johanna, Sirén, Jukka, Ahtiainen, Maarit, Böhm, Jan, Mecklin, Jukka-Pekka, Sallinen, Ville, and Seppälä, Toni T.

Subjects
CHOLANGIOCARCINOMA, PROGRAMMED cell death 1 receptors, PROGRAMMED death-ligand 1, OVERALL survival, PROGNOSIS
Abstract

Background: Antitumoral immune response has a crucial role in constraining cancer. However, previous studies on cholangiocarcinoma (CCA), a rare and aggressive cancer, have reported contradictory findings on the prognostic impact of tumorinfiltrating T-lymphocytes. We aimed to clarify the effect of tumor-infiltrating CD3+ and CD8+ lymphocytes and PD-1/PD-L1 expression on CCA prognosis. Methods: CD3+, CD8+, and PD-1+ lymphocyte densities, as well as PD-L1 expression rate were analyzed from stained tissue microarray samples from the tumor center and invasive margin of 47 cholangiocarcinomas. The association of CD3+ and CD8+ based Immune cell score (ICS) and its components with overall survival was evaluated, adjusting for age, sex, TNM stage, radicality of surgery, tumor location, and PD-L1 expression on immune cells. Results: Low ICS was a strong independent prognostic factor for worse overall survival (Hazard ratio 9.27, 95% confidence interval 2.72-31.64, P<0.001). Among the ICS components, high CD8+ lymphocyte infiltration at the tumor center had the most evident impact on patient outcome. PD-1 and PD-L1 expression on immune cells did not have a significant impact on overall survival alone; however, PD-L1 positivity seemed to impair survival for ICSlow subgroup. Conclusion: Identifying patient subgroups that could benefit from immunotherapy with PD-1/PD-L1 pathway blockade may help improve treatment strategies for this aggressive cancer. Our findings highlight the importance of evaluating the immune contexture in cholangiocarcinoma, as ICS serves as a strong independent prognostic and selective factor for patients who might benefit from immunotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The Helsinki approach to face transplantation

Author

Lindford, Andrew J, Mäkisalo, Heikki, Jalanko, Hannu, Lauronen, Jouni, Anttila, Veli-Jukka, Juteau, Susanna, Ämmälä, Antti-Jussi, Eskola, Anna, Saarni, Samuli, Isoniemi, Helena, Mäkitie, Antti, and Lassus, Patrik

Published
2019
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9. The first 10 years of simultaneous pancreas‐kidney transplantation in Finland

Author

Ahopelto, Kaisa, primary, Sallinen, Ville, additional, Helanterä, Ilkka, additional, Bonsdorff, Akseli, additional, Grasberger, Juulia, additional, Beilmann‐Lehtonen, Ines, additional, Mäkisalo, Heikki, additional, Nordin, Arno, additional, Ortiz, Fernanda, additional, Savikko, Johanna, additional, Tukiainen, Eija, additional, Uutela, Aki, additional, Ekstrand, Agneta, additional, and Lempinen, Marko, additional

Published
2023
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11. mTOR Inhibition Is Most Beneficial After Liver Transplantation for Hepatocellular Carcinoma in Patients With Active Tumors

Author

Schnitzbauer, Andreas A., Filmann, Natalie, Adam, René, Bachellier, Philippe, Bechstein, Wolf O., Becker, Thomas, Bhoori, Sherrie, Bilbao, Itxarone, Brockmann, Jens, Burra, Patrizia, Chazoullières, Olivier, Cillo, Umberto, Colledan, Michele, Duvoux, Christoph, Ganten, Tom M., Gugenheim, Jean, Heise, Michael, van Hoek, Bart, Jamieson, Neville, de Jong, Koert P., Klein, Christian G., Klempnauer, Jürgen, Kneteman, Norman, Lerut, Jan, Mäkisalo, Heikki, Mazzaferro, Vincenzo, Mirza, Darius F., Nadalin, Silvio, Neuhaus, Peter, Pageaux, George-Philippe, Pinna, Antonio D., Pirenne, Jaques, Pratschke, Johann, Powel, James, Rentsch, Markus, Rizell, Magnus, Rossi, Giorgio, Rostaing, Lionel, Roy, André, Scholz, Tim, Settmacher, Utz, Soliman, Thomas, Strasser, Simone, Söderdahl, Gunnar, Troisi, Roberto I., Turrión, Victor Sánchez, Schlitt, Hans J., and Geissler, Edward K.

Published
2020
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14. Timing of Organ Procurement From Brain-Dead Donors Associates With Short- and Long-Term Outcomes After Liver Transplantation

Author

Eerola, Verner, Helanterä, Ilkka, Åberg, Fredrik, Lempinen, Marko, Mäkisalo, Heikki, Nordin, Arno, Isoniemi, Helena, Sallinen, Ville, Clinicum, HUS Abdominal Center, IV kirurgian klinikka, Pertti Panula / Principal Investigator, Department of Anatomy, and Helsinki University Hospital Area

Subjects
organ allocation, liver allograft function, Transplantation, Tissue and Organ Procurement, DURATION, graft survival, liver transplant dysfunction, Brain, donor hepatectomy, 3126 Surgery, anesthesiology, intensive care, radiology, Severity of Illness Index, Liver Transplantation, TIME, End Stage Liver Disease, ACTIVATION, procurement surgery, SURVIVAL, Humans, brain death, FAILURE
Abstract

Brain death-induced cytokine storm is thought to harm transplantable organs. However, longer procurement times have been associated with non-inferior or better outcomes in kidney, heart, and lung transplants, while optimal procurement time for liver allografts is unknown. Our aim was to analyze the association of time interval from brain death to organ procurement with liver allograft outcomes in two nationwide cohorts. The association of procurement interval with graft survival and short-term complications was analysed in multivariable models. Altogether 643 and 58,017 orthotopic liver transplantations from brain-dead donors were included from Finland between June 2004 and December 2017 and the US between January 2008 and August 2018, respectively. Median time from brain death to organ procurement was 10.5 h in Finland and 34.6 h in the US. Longer interval associated with better graft survival (non-linearly, p = 0.016) and less acute rejections (OR 0.935 95% CI 0.894–0.978) in the US cohort, and better early allograft function (p = 0.005; Beta −0.048 95% CI −0.085 −(−0.011)) in the Finnish cohort, in multivariable models adjusted with Donor Risk Index, recipient age, Model for End-Stage Liver Disease and indication for transplantation. Progressive liver injury after brain death is unlikely. Rushing to recover seems unnecessary; rest and repair might prove beneficial.

Published
2022

15. Gamma-glutamyltransferase predicts macrovesicular liver graft steatosis – an analysis of discarded liver allografts in Finland.

Author

Savikko, Johanna, Åberg, Fredrik, Tukiainen, Eija, Nordin, Arno, Mäkisalo, Heikki, Arola, Johanna, and Isoniemi, Helena

Subjects
GAMMA-glutamyltransferase, FATTY liver, FATTY degeneration, LIVER analysis, HOMOGRAFTS, LIVER
Abstract

Liver-transplantation activity is limited by the shortage of grafts. Donor-liver macrovesicular steatosis predisposes to ischemia-reperfusion injury and is associated with reduced graft survival. The increasing prevalence of fatty-liver disease underlines the importance of identifying macrovesicular steatosis in potential donor livers. We analyzed liver grafts discarded for transplantation, and particularly the role of gamma-glutamyltransferase (GGT) in predicting graft steatosis. One-hundred sixty rejected cadaveric-donor liver grafts were studied. Donor selection was based on clinical data, and macroscopic graft inspection. Discarded grafts were biopsied at procurement of non-liver organs. The most common reasons for discarding the graft were abnormal liver tests, ultrasound-verified steatosis and history of harmful alcohol use. GGT correlated moderately with macrovesicular steatosis (r = 0.52, p < 0.001), but poorly with microvesicular steatosis (r = 0.36, p < 0.001). Increased correlation between GGT and macrovesicular steatosis was observed among alcohol abusers (r = 0.67, p < 0.001). Area under the curve (AUC) of GGT for predicting >30% macrovesicular steatosis was 0.79 (95% CI 0.71–0.88), and for >60% steatosis, 0.79 (95% CI 0.68–0.90). The optimal GGT-cut off for detecting >30% and >60% macrovesicular steatosis were, respectively, 66 U/L (sensitivity 76% and specificity 68%) and 142 U/L (sensitivity 66% and specificity 83%). Among alcohol users, a GGT value >90 U/L showed 100% sensitivity for >60% macrovesicular steatosis. AUC for GGT in predicting fibrosis Stages 2–4 was 0.82 (95% CI 0.71–0.92, p < 0.001, optimal cut off 68, sensitivity 92%, specificity 61%). Abnormal liver values, steatosis and harmful alcohol use were the main reasons for discarding liver-graft offers in Finland. GGT proved useful in predicting moderate and severe liver graft macrovesicular steatosis. [ABSTRACT FROM AUTHOR]

Published
2023
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16. HCC recurrence in HCV‐infected patients after liver transplantation: SiLVER Study reveals benefits of sirolimus in combination with CNIs – a post‐hoc analysis

Author

Werner, Jens M., Hornung, Matthias, Krah, Rubertha, Götz, Markus, Schnitzbauer, Andreas A., Schlitt, Hans J., Geissler, Edward K., Zülke, Carl, Lamby, Philipp E., Proneth, Andrea, Duvoux, Christophe, Burra, Patrizia, Jauch, Karl‐Walter, Rentsch, Markus, Ganten, Tom M., Schmidt, Jan, Settmacher, Utz, Heise, Michael, Rossi, Giorgio, Cillo, Umberto, Kneteman, Norman, Adam, René, Hoek, Bart, Bachellier, Philippe, Wolf, Philippe, Rostaing, Lionel, Bechstein, Wolf O., Rizell, Magnus, Powell, James, Hidalgo, Ernest, Gugenheim, Jean, Wolters, Heiner, Brockmann, Jens, Roy, André, Mutzbauer, Ingrid, Schlitt, Angela, Beckebaum, Susanne, Graeb, Christian, Nadalin, Silvio, Valente, Umberto, Turrión, Victor Sánchez, Jamieson, Neville, Scholz, Tim, Colledan, Michele, Fändrich, Fred, Becker, Thomas, Söderdahl, Gunnar, Chazouillères, Olivier, Mäkisalo, Heikki, Pageaux, Georges‐Philippe, Steininger, Rudolf, Soliman, Thomas, Jong, Koert P., Pirenne, Jacques, Margreiter, Raimund, Pratschke, Johann, Pinna, Antonio D., Hauss, Johann, Schreiber, Stefan, Strasser, Simone, Klempnauer, Jürgen, Troisi, Roberto I., Bhoori, Sherrie, Lerut, Jan, Bilbao, Itxarone, Klein, Christian G., Königsrainer, Alfred, Otto, Gerd, Mazzaferro, Vincenzo, Neuhaus, Peter, Werner, J, Hornung, M, Krah, R, Gotz, M, Schnitzbauer, A, Schlitt, H, Geissler, E, Zulke, C, Lamby, P, Proneth, A, Duvoux, C, Burra, P, Jauch, K, Rentsch, M, Ganten, T, Schmidt, J, Settmacher, U, Heise, M, Rossi, G, Cillo, U, Kneteman, N, Adam, R, Hoek, B, Bachellier, P, Wolf, P, Rostaing, L, Bechstein, W, Rizell, M, Powell, J, Hidalgo, E, Gugenheim, J, Wolters, H, Brockmann, J, Roy, A, Mutzbauer, I, Schlitt, A, Beckebaum, S, Graeb, C, Nadalin, S, Valente, U, Turrion, V, Jamieson, N, Scholz, T, Colledan, M, Fandrich, F, Becker, T, Soderdahl, G, Chazouilleres, O, Makisalo, H, Pageaux, G, Steininger, R, Soliman, T, Jong, K, Pirenne, J, Margreiter, R, Pratschke, J, Pinna, A, Hauss, J, Schreiber, S, Strasser, S, Klempnauer, J, Troisi, R, Bhoori, S, Lerut, J, Bilbao, I, Klein, C, Konigsrainer, A, Otto, G, Mazzaferro, V, and Neuhaus, P

Subjects
Silver Study, medicine.medical_specialty, Carcinoma, Hepatocellular, Silver, direct-acting antiviral agents, medicine.medical_treatment, 610 Medizin, Subgroup analysis, 030230 surgery, Liver transplantation, Gastroenterology, Group B, 03 medical and health sciences, HEPATOCELLULAR-CARCINOMA, hepatitis C virus infection, hepatocellular carcinoma, liver transplantation, 0302 clinical medicine, Internal medicine, Post-hoc analysis, medicine, Humans, Sirolimus, direct-acting antiviral agent, ddc:610, Transplantation, business.industry, Liver Neoplasms, Immunosuppression, medicine.disease, Hepatitis C, digestive system diseases, Calcineurin, Hepatocellular carcinoma, 030211 gastroenterology & hepatology, Neoplasm Recurrence, Local, business, medicine.drug
Abstract

Factors affecting outcomes in liver transplant (LTx) recipients with hepatocellular carcinoma (HCC) and hepatitis C viral (HCV) infection include the choice of immunosuppression. Here, we analyzed the HCV+ subgroup of patients from the randomized controlled, international SiLVER Study. We performed a post hoc analysis of 166 HCV+ SiLVER Study patients regarding HCC outcome after LTx. Control patients (group A: n=88) received mTOR inhibitor (mTORi)-free, calcineurin inhibitor (CNI)-based versus sirolimus-based immunosuppression (group B: n=78). We found no significant difference regarding HCV-RNA titers between group A and B. Since no effect in group B could be due to variable sirolimus dosing, we split group B into patients receiving sirolimus-based immunosuppression+CNIs for >50% (B1; n=44) or

Published
2020

18. Sirolimus Use in Liver Transplant Recipients With Hepatocellular Carcinoma: A Randomized, Multicenter, Open-Label Phase 3 Trial

Author

Geissler, Edward K., Schnitzbauer, Andreas A., Zülke, Carl, Lamby, Philipp E., Proneth, Andrea, Duvoux, Christophe, Burra, Patrizia, Jauch, Karl-Walter, Rentsch, Markus, Ganten, Tom M., Schmidt, Jan, Settmacher, Utz, Heise, Michael, Rossi, Giorgio, Cillo, Umberto, Kneteman, Norman, Adam, René, van Hoek, Bart, Bachellier, Philippe, Wolf, Philippe, Rostaing, Lionel, Bechstein, Wolf O., Rizell, Magnus, Powell, James, Hidalgo, Ernest, Gugenheim, Jean, Wolters, Heiner, Brockmann, Jens, Roy, André, Mutzbauer, Ingrid, Schlitt, Angela, Beckebaum, Susanne, Graeb, Christian, Nadalin, Silvio, Valente, Umberto, Turrión, Victor Sánchez, Jamieson, Neville, Scholz, Tim, Colledan, Michele, Fändrich, Fred, Becker, Thomas, Söderdahl, Gunnar, Chazouillères, Olivier, Mäkisalo, Heikki, Pageaux, Georges-Philippe, Steininger, Rudolf, Soliman, Thomas, de Jong, Koert P., Pirenne, Jacques, Margreiter, Raimund, Pratschke, Johann, Pinna, Antonio D., Hauss, Johann, Schreiber, Stefan, Strasser, Simone, Klempnauer, Jürgen, Troisi, Roberto I., Bhoori, Sherrie, Lerut, Jan, Bilbao, Itxarone, Klein, Christian G., Königsrainer, Alfred, Mirza, Darius F., Otto, Gerd, Mazzaferro, Vincenzo, Neuhaus, Peter, and Schlitt, Hans J.

Published
2016
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19. Treatment response of colorectal cancer liver metastases to neoadjuvant or conversion therapy: a prospective multicentre follow-up study using MRI, diffusion-weighted imaging and 1H-MR spectroscopy compared with histology (subgroup in the RAXO trial)

Author

Uutela, A., primary, Ovissi, A., additional, Hakkarainen, A., additional, Ristimäki, A., additional, Lundbom, N., additional, Kallio, R., additional, Soveri, L.M., additional, Salminen, T., additional, Ålgars, A., additional, Halonen, P., additional, Ristamäki, R., additional, Nordin, A., additional, Blanco Sequeiros, R., additional, Rinta-Kiikka, I., additional, Lantto, E., additional, Virtanen, J., additional, Pääkkö, E., additional, Liukkonen, E., additional, Saunavaara, J., additional, Ryymin, P., additional, Lammentausta, E., additional, Osterlund, P., additional, Isoniemi, H., additional, Mäkisalo, Heikki, additional, Huuhtanen, Riikka, additional, Kosunen, Juhani, additional, Leppä, Sirpa, additional, Bono, Petri, additional, Mattson, Johanna, additional, Österlund, Emerik, additional, Penttinen, Heidi, additional, Mäkelä, Siru, additional, Carpén, Olli, additional, Timonen, Marjut, additional, Lehtomäki, Kaisa, additional, Salminen, Veera, additional, Paunu, Niina, additional, Vornanen, Martine, additional, Lasse, Nieminen, additional, Heervä, Eetu, additional, Korkeila, Eija, additional, Sutinen, Eija, additional, Lavonius, Maija, additional, Sundström, Jari, additional, Mäkinen, Markus, additional, and Poussa, Tuija, additional

Published
2021
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21. Sopeutuminen - alistumista vai selviytymistä?

Author

Rapola, Janne, Heikinheimo, Oskari, Rovasalo, Aki, Mäkisalo, Heikki, Sisätautien osasto, Clinicum, Naistenklinikka, HUS Naistentaudit ja synnykset, HUS Vatsakeskus, and IV kirurgian klinikka

Subjects
3141 Terveystiede, Adaptation, Psychological, Environment, Pandemics, Illness Behavior
Abstract

Teema : sopeutuminen. Kuuntele podcast jossa Kari Hevossaari keskustelee joulunumeron päätoimittajan Janne Rapolan kanssa numeron teemasta sopeutumisesta.

Published
2021

30. Randomised sham-controlled double-blind trial evaluating remote ischaemic preconditioning in solid organ transplantation: a study protocol for the RIPTRANS trial

Author

Uutela, Aki, primary, Helanterä, Ilkka, additional, Lemström, Karl, additional, Passov, Arie, additional, Syrjälä, Simo, additional, Åberg, Fredrik, additional, Mäkisalo, Heikki, additional, Nordin, Arno, additional, Lempinen, Marko, additional, and Sallinen, Ville, additional

Published
2020
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46. Maksaportin sappitiesyöpä eli Klatskinin tuumori

Author

Sallinen, Ville, Peltola, Katriina, Mäkisalo, Heikki, Pertti Panula / Vastuullinen tutkija, IV kirurgian klinikka, Clinicum, Syöpätautien osasto, HUS Syöpäkeskus, and HUS Vatsakeskus

Subjects
3122 Syöpätaudit, 3126 Kirurgia, anestesiologia, tehohoito, radiologia
Abstract

Teema : maksa- , haima- ja sappitiekirurgia. English summary

Published
2019

47. Kun Morgagni ja Caesar tapasivat

Author

Andersson, Saana, Mäkisalo, Heikki, HUS Sydän- ja keuhkokeskus, Sydän ja rintaelinkirurgia, Kirurgian osasto, HUS Vatsakeskus, and IV kirurgian klinikka

Subjects
3126 Kirurgia, anestesiologia, tehohoito, radiologia
Abstract

Teema : syntymä

Published
2019

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