1. Death Effector Domain-Containing Proteins
- Author
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Joe W. Ramos and M. Gudur Valmiki
- Subjects
Models, Molecular ,Death Domain Receptor Signaling Adaptor Proteins ,Programmed cell death ,GTPase-activating protein ,Protein Conformation ,DEDD ,Apoptosis ,Biology ,Cellular and Molecular Neuroscience ,Morphogenesis ,Animals ,Humans ,Protein Isoforms ,FADD ,Molecular Biology ,Cell Proliferation ,Death domain ,Pharmacology ,Effector ,Cell Biology ,Cell biology ,biology.protein ,Molecular Medicine ,Death effector domain ,Signal transduction ,Signal Transduction - Abstract
Death effector domains (DEDs) are protein-protein interaction structures that are found in proteins that regulate a variety of signal transduction pathways. DEDs are a part of the larger family of Death Domain structures that have been primarily described in the control of programmed cell death. The seven standard DED-containing proteins are fas associated death domain protein (FADD), Caspase-8 and 10, cellular FLICE-like inhibitory protein (c-FLIP), death effector domain containing DNA binding (DEDD), DEDD2 and phosphoprotein enriched in astrocytes 15-Kda (PEA-15). These proteins are particularly associated with the regulation of apoptosis and proliferation mediated by the tumor necrosis factor alpha (TNFalpha) receptor family. Consequently DED-containing proteins are reported to regulate transcription, migration, and proliferation, in addition to both pro and anti-apoptotic functions. Moreover, DED proteins are essential in embryonic development and homeostasis of the immune system. Here we focus on the role of DED-containing proteins in development and the pathologies arising from abnormal expression of these proteins. more...
- Published
- 2008
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